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6. Fatigue of NbOx-Based Locally Active Memristors—Part I: Experimental Characteristics

Author

Ding, Yanting, Li, Yu, Jia, Shujing, Chen, Pei, Zhang, Xumeng, Wang, Wei, Li, Yang, Hao, Yunxia, Bi, Jinshun, Gong, Tiancheng, Jiang, Hao, Wang, Ming, Liu, Qi, Xu, Ningsheng, and Liu, Ming

Abstract

NbOx-based devices exhibit intriguing promise for beyond-CMOS applications due to their dynamic threshold switching (TS) and negative differential resistance (NDR) behaviors. However, an in-depth study on the degradation scheme of such a device is absent. In this work, we investigate the degradation behavior, i.e., the shift of switching voltages ( ${V}_{\text {th}}$ , ${V}_{\text {hold}}$ ) and the shrink of voltage window (VW), of a nanoscale forming-free TiN/NbOx/TiN memristor. Through electrical tests and random telegraph noise (RTN)-based defect tracking, we proved that the shrink of the VW and the increase of switching voltages originate from the increase of electrode resistance due to the oxygen vacancy accumulation. According to the elucidated degradation mechanisms, we propose a reverse refresh strategy to extend the endurance and delay VW degradation. This work provides a possible view of NbOx devices’ degradation and may promote the applications.

Published
2023
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7. Fatigue of NbO$_{\textit{x}}$-Based Locally Active Memristors—Part I: Experimental Characteristics

Author

Ding, Yanting, primary, Li, Yu, additional, Jia, Shujing, additional, Chen, Pei, additional, Zhang, Xumeng, additional, Wang, Wei, additional, Li, Yang, additional, Hao, Yunxia, additional, Bi, Jinshun, additional, Gong, Tiancheng, additional, Jiang, Hao, additional, Wang, Ming, additional, Liu, Qi, additional, Xu, Ningsheng, additional, and Liu, Ming, additional

Published
2023
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12. Novel 4-arylaminoquinazolines bearing N,N-diethyl(aminoethyl)amino moiety with antitumour activity as EGFRwt-TK inhibitor

Author

Gao Li, Yaling Zhang, Yaping Yan, Baolin Li, Xiabing Li, Hao Yunxia, and Li Chen

Subjects
Stereochemistry, Antineoplastic Agents, Apoptosis, Structure-Activity Relationship, Drug Discovery, Tumor Cells, Cultured, Humans, Moiety, heterocyclic compounds, Protein Kinase Inhibitors, Cell Proliferation, Pharmacology, quinazoline derivatives, Quinazoline derivatives, wild type epidermal growth factor receptor tyrosine kinase (egfrwt-tk), Dose-Response Relationship, Drug, Molecular Structure, integumentary system, Chemistry, n,n-diethyl(aminoethyl)amino moiety, organic chemicals, Cell Cycle, lcsh:RM1-950, antiproliferative activities, General Medicine, molecular docking, In vitro, ErbB Receptors, Molecular Docking Simulation, lcsh:Therapeutics. Pharmacology, Quinazolines, Original Article, Drug Screening Assays, Antitumor
Abstract

Herein, four novel 4-arylaminoquinazoline derivatives with N,N-diethyl(aminoethyl)amino moiety were designed, synthesised and evaluated on biological activities in vitro. All synthesised compounds have inhibitory effects against tumour cells (SW480, A549, A431 and NCI-H1975). In particular, 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-6-(5-((N,N-diethyl(aminoethyl))aminomethyl)furan-2-yl)quinazoline (6a) and 6-(5-((N,N-diethylethyl)aminomethyl)furan-2-yl)-4-(4-(E)-(propen-1-yl)phenylamino)quinazoline (6d) were potent antitumour agents which showed high antiproliferative activities against tumour cells in vitro. Moreover, compound 6a could induce late apoptosis of A549 cells at high concentrations and arrest cell cycle of A549 cells in the G0/G1 phase at tested concentrations. Also, compound 6a could inhibit the activity of wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) with IC50 value of 15.60 nM. Molecular docking showed that compound 6a formed three hydrogen bonds with EGFRwt-TK, while lapatinib formed only two hydrogen bonds with the receptor protein. It is believed that this work would be giving a reference for developing anti-cancer drugs targeted EGFR-TK., Graphical Abstract

Published
2019
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13. Vascular Cell Co-Culture on Silk Fibroin Matrix

Author

Helei Li, Yin Yin, Honggen Yi, Fangfang Tu, Jiannan Wang, Pange Shi, Yunfei Liu, Yue Wu, and Hao Yunxia

Subjects
CD31, Vascular smooth muscle, Polymers and Plastics, 02 engineering and technology, 010402 general chemistry, Cell morphology, 01 natural sciences, Umbilical vein, Article, chemistry.chemical_compound, cells interaction, Vascular tissue, Keywords: vascular cells, vascular cells, co-culture, silk fibroin, proliferative activity, General Chemistry, 021001 nanoscience & nanotechnology, Molecular biology, 0104 chemical sciences, Transplantation, Endothelial stem cell, Vascular endothelial growth factor, chemistry, 0210 nano-technology
Abstract

Silk fibroin (SF), a natural polymer material possessing excellent biocompatibility and biodegradability, and has been widely used in biomedical applications. In order to explore the behavior of vascular cells by co-culturing on regenerated SF matrix for use as artificial blood vessels, human aorta vascular smooth muscle cells (HAVSMCs) were co-cultured with human arterial fibroblasts (HAFs) or human umbilical vein endothelial cells (HUVECs) on SF films and SF tubular scaffolds (SFTSs). Analysis of cell morphology and deoxyribonucleic acid (DNA) content showed that HUVECs, HAVSMCs and HAFs adhered and spread well, and exhibited high proliferative activity whether cultured alone or in co-culture. Immunofluorescence and scanning electron microscopy (SEM) analysis showed that HUVECs and HAFs co-existed well with HAVSMCs on SF films or SFTSs. Cytokine expression determined by reverse transcription-polymerase chain reaction (RT-PCR) indicated that the expression levels of α-smooth muscle actin (α-SMA) and smooth muscle myosin heavy chain (SM-MHC) in HAVSMCs were inhibited on SF films or SFTSs, but expression could be obviously promoted by co-culture with HUVECs or HAFs, especially that of SM-MHC. On SF films, the expression of vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule-1 (CD31) in HUVECs was promoted, and the expression levels of both increased obviously when co-cultured with HAVSMCs, with the expression levels of VEGF increasing with increasing incubation time. The expression levels of VEGF and CD31 in cells co-cultured on SFTSs improved significantly from day 3 compared with the mono-culture group. These results were beneficial to the mechanism analysis on vascular cell colonization and vascular tissue repair after in vivo transplantation of SFTSs.

Published
2018

16. Abstracts From the 13th World Congress of the World Federation of Critical Care Nurses and 10th Congress of the Serbian Society of Intensive Care, Anesthaesiology and Resuscitation (UINARS), Belgrade, Serbia, 25–28 October 2018

Author

Abeddin, Laila, primary, Ahmetbegovic, Marina, primary, Barkestad, Eva, primary, Cao, Shuyin, primary, Ceylan, Burcu, primary, Chen, Xiuwan, primary, Christensen, Mathilde Elsa, primary, Cingil, Dilek, primary, Coetzee, Isabel, primary, Cvijanović, Dušanka, primary, Dragica, Dobrović, primary, Dragosev, Gordana, primary, Du, Aiping, primary, Elmedin, Dubravac, primary, Dugonjić, Mario, primary, Friganovic, Adriano, primary, Fulbrook, Paul, primary, Goldsworthy, Sandra, primary, Ivanišić, Martina, primary, Ivankovic, Sanja, primary, Jankovic, Radmilo, primary, Jing, Wenwen, primary, Kleinpell, Ruth, primary, Küççük, Burcu, primary, Küçük, Sibel, primary, Kurtović, Sofija, primary, Lana, Rodić, primary, Lazarevic, Zorica, primary, Li, Qing, primary, Liao, Yao, primary, Liu, Huan, primary, Livesay, Sarah, primary, Lopez, Violeta, primary, Meštrović, Mirjana, primary, Mitchell, Marion, primary, Morales, Marcelo, primary, Mustu, Perver, primary, Nemes, Marjetka, primary, Panova, Gordana, primary, Peličić, Damir, primary, Ristic, Sasa, primary, Rodić, Lana, primary, Rogado, Maria Isabelita, primary, Saide, Faydalı, primary, José, Alicia San, primary, San José, Alicia, primary, Seferovic, Sasa, primary, Şerife, Kurşun, primary, Sheng, Han, primary, Shi, Li, primary, Simic, Marija, primary, Slijepčević, Jelena, primary, Stefanovic, Mirela, primary, Stojanovic, Emina, primary, Sü, Serpil Akbaş, primary, Sun, Jianhua, primary, Thorsteinsdóttir, Rósa, primary, Tian, Yongming, primary, MeryemTürkan, Işik, primary, Uçar, Ayşe, primary, Ugras, Gulay Altun, primary, Vidmanić, Sandro, primary, Vollman, Kathleen, primary, Vuckovic, Maja, primary, Wang, Limei, primary, Wang, Rong, primary, Wang, Chunyan, primary, Williams, Ged, primary, Wu, Yuchen, primary, Xu, Nana, primary, Xu, Yu, primary, Yao, Li, primary, Yeager, Susan, primary, Yu, Meng, primary, Zelic, Samela, primary, Zhang, Na, primary, Zhao, Lin, primary, Zhong, Jun, primary, Yang, Hui, additional, Li, Liming, additional, Zhu, Shichao, additional, Pei, Yongju, additional, Semiz, Mustafa, additional, Zhu, Haihua, additional, Klette, Maria Ingrid Bianca, additional, Hansen, Britt Sætre, additional, Gürel, Ayşenur, additional, Başer, Gülfidan, additional, Hisar, Filiz, additional, Milovanovic, Jelena, additional, Mirjana, Maletic, additional, Ristic, Sasa, additional, Stefanovic, Mirela, additional, Savic, Biljana, additional, Miljana, Gutovic, additional, Kurtovic, Sofija, additional, Maletic, Mirjana, additional, Dimitric, Daliborka, additional, Savić, Biljana, additional, Majstorović, Dunja, additional, Liu, Huan, additional, Xu, Yu, additional, Tian, Yongming, additional, Marcucci, Emanuela, additional, Williams, Ged, additional, Kleinpell, Ruth, additional, Alberto, Laura, additional, Witton, Nicola, additional, Šarika, Gajnok, additional, Belgin, Akin, additional, Tosun, Alime Selçuk, additional, Uludasdemir, Dilek, additional, Mustu, Perver, additional, Özeflanili, Ayşe, additional, Neuberg, Marijana, additional, Kišić, Kristina, additional, Hereković, Dijana, additional, Lukić, Anita, additional, Lukic, Branko, additional, Wu, Xiaoying, additional, Jin, Xi, additional, Guo, Zhi, additional, Du, Aiping, additional, Vrgoč, Jelena, additional, Bespaljko, Mario, additional, Lončar, Ivan, additional, Kucuk, Sibel, additional, Boshkovska, Jasna, additional, Panova, Blagica, additional, Dobrovic, Dragica, additional, Stamenkovic, Danica, additional, Stankovic, Miljana, additional, Antonijevic, Nikola, additional, Çakir, Büşra, additional, Çiftçi, Özlem, additional, Zhang, Hongyan, additional, Zhang, Limei, additional, Liu, Xueying, additional, Wang, Rong, additional, Li, Qingyin, additional, Yu, Meng, additional, Zhuang, Feifei, additional, Zhang, Lin, additional, Momcilovic, Marija, additional, Jovanovic, Jagica, additional, Jankovic, Suzana, additional, Demirören, Nesime, additional, Zhang, Qing, additional, Guo, Hailing, additional, Sun, Hong, additional, Wang, Xiaoting, additional, Yıldırım, Gülay, additional, Arslan, Selda, additional, Isik, Meryem Turkan, additional, Serinol, Hasan, additional, Babic, Sabina, additional, Friganovic, Adriano, additional, Vratan, Nikolina, additional, Jelic, Sanja, additional, Sheng, Han, additional, Yu, Huijie, additional, Wang, Limei, additional, Xia, Jianmei, additional, Zhang, Zhigang, additional, Zhang, Caiyun, additional, Tian, Jinhui, additional, Wang, Hao, additional, Zhou, Min, additional, Du, A., additional, Tian, Y., additional, Zhang, Zhi-Gang, additional, Tian, Jin-Hui, additional, Zhang, Cai-Yun, additional, Ding, Nannan, additional, Huang, D., additional, Yan, P., additional, Li, Q., additional, Li, Qing Yin, additional, Huo, ChunYing, additional, Hao, YunXIA, additional, Shi, Li, additional, Liu, Lin, additional, Zheng, Jili, additional, Xue, Yan, additional, and Zhang, Jingyi, additional

Published
2018
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17. Novel 4-arylaminoquinazolines bearing N,N-diethyl(aminoethyl)amino moiety with antitumour activity as EGFRwt-TK inhibitor.

Author

Zhang, Yaling, Chen, Li, Li, Xiabing, Gao, Li, Hao, Yunxia, Li, Baolin, and Yan, Yaping

Subjects
EPIDERMAL growth factor receptors, PROTEIN-tyrosine kinases, MOLECULAR docking, HYDROGEN bonding
Abstract

Herein, four novel 4-arylaminoquinazoline derivatives with N,N-diethyl(aminoethyl)amino moiety were designed, synthesised and evaluated on biological activities in vitro. All synthesised compounds have inhibitory effects against tumour cells (SW480, A549, A431 and NCI-H1975). In particular, 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-6-(5-((N,N-diethyl(aminoethyl))aminomethyl)furan-2-yl)quinazoline (6a) and 6-(5-((N,N-diethylethyl)aminomethyl)furan-2-yl)-4-(4-(E)-(propen-1-yl)phenylamino)quinazoline (6d) were potent antitumour agents which showed high antiproliferative activities against tumour cells in vitro. Moreover, compound 6a could induce late apoptosis of A549 cells at high concentrations and arrest cell cycle of A549 cells in the G0/G1 phase at tested concentrations. Also, compound 6a could inhibit the activity of wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) with IC50 value of 15.60 nM. Molecular docking showed that compound 6a formed three hydrogen bonds with EGFRwt-TK, while lapatinib formed only two hydrogen bonds with the receptor protein. It is believed that this work would be giving a reference for developing anti-cancer drugs targeted EGFR-TK. [ABSTRACT FROM AUTHOR]

Published
2019
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19. Vascular Cell Co-Culture on Silk Fibroin Matrix

Author

Tu, Fangfang, primary, Liu, Yunfei, additional, Li, Helei, additional, Shi, Pange, additional, Hao, Yunxia, additional, Wu, Yue, additional, Yi, Honggen, additional, Yin, Yin, additional, and Wang, Jiannan, additional

Published
2018
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21. Charge trapping memory device based on the Ga2O3 films as trapping and blocking layer.

Author

Bai, Bing, Wang, Hong, Li, Yan, Hao, Yunxia, Zhang, Bo, Wang, Boping, Wang, Zihang, Yang, Hongqi, Gao, Qihang, Lü, Chao, Zhang, Qingshun, and Yan, Xiaobing

Subjects
COMPUTER storage devices, TRANSMISSION electron microscopy, MAGNETRON sputtering, HIGH voltages, TEMPERATURE control
Abstract

We present a new charge trapping memory (CTM) device with the Au/Ga2O3/SiO2/Si structure, which is fabricated by using the magnetron sputtering, high-temperature annealing, and vacuum evaporation techniques. Transmission electron microscopy diagrams show that the thickness of the SiO2 tunneling layer can be controlled by the annealing temperature. When the devices are annealed at 760 °C, the measured C–V hysteresis curves exhibit a maximum 6 V memory window under a ±13 V sweeping voltage. In addition, a slight degradation of the device voltage and capacitance indicates the robust retention properties of flat-band voltage and high/low state capacitance. These distinctive advantages are attributed to oxygen vacancies and inter-diffusion layers, which play a critical role in the charge trapping process. [ABSTRACT FROM AUTHOR]

Published
2019
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24. Hemocompatibility and cytocompatibility of the hirudin-modified silk fibroin.

Author

Sun, Dan, Hao, Yunxia, Yang, Gaoqiang, and Wang, Jiannan

Abstract

Hirudin (Hir), a thrombin direct inhibitor, was used to modify a polyethylene glycol diglycidyl ether (PEG-DE) crosslinked regenerated silk fibroin (SF) material to improve hemocompatibility. Hemolysis characteristics, platelet adhesion, platelet activity, and plasma recalcification time were investigated using absorption spectrometry, scanning electron microscopy, MTT analysis, and the time counting method. Hirudin could be grafted evenly to the silk fibroin, and the modified material was resistant to hemolysis at ratios of less than 0.5%. Scanning electron microscopy and MTT results showed that platelet adhesion and aggregation activity decreased after modificaton with trace amounts of hirudin, compared with PEG-DE crosslinked and ethanol-treated silk fibroin film. Plasma recalcification of PEG-DE crosslinked silk fibroin film was slower than with ethanol-treated material, and this increased slightly after hirudin modification. Furthermore, L929, HAVSMC, and HUVEC cells adhered to the modified material, grew well, and possessed high proliferation activity on SF/Hir blend films. This study suggests that hirudin could improve the anticoagulation properties of regenerated silk fibroin materials. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 556-562, 2015. [ABSTRACT FROM AUTHOR]

Published
2015
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25. Novel 4-arylaminoquinazolines bearing N , N -diethyl(aminoethyl)amino moiety with antitumour activity as EGFR wt -TK inhibitor.

Author

Zhang Y, Chen L, Li X, Gao L, Hao Y, Li B, and Yan Y

Subjects
Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Apoptosis drug effects, Cell Cycle drug effects, Cell Proliferation drug effects, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, ErbB Receptors antagonists & inhibitors, ErbB Receptors metabolism, Humans, Molecular Docking Simulation, Molecular Structure, Protein Kinase Inhibitors chemical synthesis, Protein Kinase Inhibitors chemistry, Quinazolines chemical synthesis, Quinazolines chemistry, Structure-Activity Relationship, Tumor Cells, Cultured, Antineoplastic Agents pharmacology, Protein Kinase Inhibitors pharmacology, Quinazolines pharmacology
Abstract

Herein, four novel 4-arylaminoquinazoline derivatives with N , N -diethyl(aminoethyl)amino moiety were designed, synthesised and evaluated on biological activities in vitro . All synthesised compounds have inhibitory effects against tumour cells (SW480, A549, A431 and NCI-H1975). In particular, 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-6-(5-(( N , N -diethyl(aminoethyl))aminomethyl)furan-2-yl)quinazoline ( 6a ) and 6-(5-(( N , N -diethylethyl)aminomethyl)furan-2-yl)-4-(4-( E )-(propen-1-yl)phenylamino)quinazoline ( 6d ) were potent antitumour agents which showed high antiproliferative activities against tumour cells in vitro . Moreover, compound 6a could induce late apoptosis of A549 cells at high concentrations and arrest cell cycle of A549 cells in the G0/G1 phase at tested concentrations. Also, compound 6a could inhibit the activity of wild type epidermal growth factor receptor tyrosine kinase (EGFR wt -TK) with IC 50 value of 15.60 nM. Molecular docking showed that compound 6a formed three hydrogen bonds with EGFR wt -TK, while lapatinib formed only two hydrogen bonds with the receptor protein. It is believed that this work would be giving a reference for developing anti-cancer drugs targeted EGFR-TK.

Published
2019
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