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An extensive literature search to identify and collect studies related to the toxicity of polybrominated diphenyl ethers (PBDEs), tetrabromobisphenol A (TBBPA) and brominated phenols (BPs) was performed in the three databases PubMed, Web of Science and SciFinder® for four Areas. After combination of the searches from the three databases and removal of the duplicates, the total number of references for Area 1 was 6,231, for Area 2 was 8,236, for Area 3 was 4,994 and for Area 4 was 6,363. The evaluation of all retrieved references for relevance by screening the title and abstract (if available) and applying eligibility criteria (inclusion/exclusion) resulted in a total number of relevant references for Area 1 of 378 (PBDEs), 46 (TBBPA) and 29 (BPs), for Area 2 of 188 (PBDEs), 37 (TBBPA) and 4 (BPs), for Area 3 of 518 (PBDEs), 180 (TBBPA) and 49 (BPs), and for Area 4 of 717 (PBDEs), 59 (TBBPA) and 18 (BPs).

I forbindelse med at FVST har modtaget en sag fra Polen angående Recidue level over MRL for tilmicosin i kalkunkød fra Polen. Vil FVST gerne anmode DTU om en risikovurdering om produktet er farligt eller uegnet til konsum jf. art. 14 i forordning 178/2002. Desuden vil vi også gerne høre fra jer, om produktet evt. er ulovligt.

It is known that SEM accumulates in bones, binds to proteins and is likely to be produced during purification of proteins. It may also occur in food/feed products due to: nitrofuran or nitrofurazone being metabolized to SEM, natural occurrence in the environment and certain food sources (such as shrimps) as well as other processing of food/feed.

In recent years, a great intensification in the use of various elements especially in modern technology can be observed. However, the anthropogenic activities, including industrialisation, urbanisation or intensive agriculture, have led to the release of many of the elements into the environment. The consequence of the accumulation of the elements both in soil and water systems is their presence in the food chain. Inhalation and consumption of the contaminated food and beverages have been indicated as the main pathways of the exposure to many elements. Due to the fact, that tea is considered the second most popular beverage worldwide and its consumption is constantly increasing, it is crucial to evaluate the safety of the product, especially for toxic elements contamination. Thus, the aim of the project was to evaluate the contamination levels of rare earth elements (REEs) including lanthanides, scandium (Sc) and yttrium (Y) and also antimony (Sb), barium (Ba), boron (B), lithium (Li), tellurium (Te), thallium (Tl) and vanadium (V) in teas. Subsequently, the risk assessment was carried out. Additionally, the Fellowship provided hands-on training on the evaluation of applications of new biocides and participation in the science-based advises given to the Danish Food and Veterinary Administration, Danish Environment Protection Agency and Danish Medical Agency.

Fødevarestyrelsen har bedt DTU Fødevareinstituttet om en sundhedsmæssig risikovurdering af et restindhold på 115 mg/kg af klorat i en prøve af ærteprotein. MRL for klorat i ærter er 0,35 mg/kg.

Fødevarestyrelsen har bedt DTU Fødevareinstituttet om en sundhedsmæssig risikovurdering af et restindhold på 36,95 mg/kg af chlorat i en prøve af kanel. MRL er 0,05 mg/kg.

Fødevarestyrelsen har bedt DTU Fødevareinstituttet om en sundhedsmæssig risikovurdering af et restindhold på 0,038 mg/kg af chlorpyrifos i en prøve af hvide. MRL er 0,01* mg/kg.

Fødevarestyrelsen har bedt DTU Fødevareinstituttet om en sundhedsmæssig risikovurdering af et restindhold på 0,17 mg/kg af chlorat i en prøve af økologiske chiafrø. MRL er 0,05 mg/kg.

Der er er i en rutineprøve af ørred fra et dambrug fundet indhold af dimetridazol på 0,27 µg/kg. Der blev udtaget to fisk fra samme dambrug til samme analyse d. 23/10, og i den anden fisk blev der også fundet spor af dimetridazol, dog ikke over aktionsgrænsen på 0,18 µg/kg. I den forbindelse er DTU Fødevareinstituttet blevet bedt om, at gennemføre en risikovurdering for humant indtag.

DTU Fødevareinstituttet blev bedt om at vurdere en eventuel fødevarerisiko ved indtagelse af fasaner med indhold af fenbendazol.

Det er foreslået af kommissionen at tillade anvendelse af et produkt indeholdende de 2 sjældne jordarter cerium og lanthan som fodertilsætninsstof til diende smågrise. I den forbindelse har FVST bedt DTU Fødevareinstituttet om at vurdere den humane risiko ved indtag af produkter fra dyr, der er behandlet med disse midler. Vurderingen blev gennemført med en meget kort deadline.

Firma X ønsker a genanvende vand fra produktionen. Det vil kunne medføre, at mindre mængder af dette vand vil blive indtaget af arbejdspladsens medarbejdere. Fødevarestyrelsen har i den forbindelse bedt DTU Fødevareinstituttet om, at vurdere en eventuel sundhedsmæssig risiko forårsaget afkemikalier i dette vand., Firma X ønsker a genanvende vand fra produktionen. Det vil kunne medføre, at mindre mængder af dette vand vil blive indtaget af arbejdspladsens medarbejdere. Fødevarestyrelsen har i den forbindelse bedt DTU Fødevareinstituttet om, at vurdere en eventuel sundhedsmæssig risiko forårsaget afkemikalier i dette vand.

An extensive literature search to identify and collect studies related to the toxicity of grayanotoxins and 5‐hydroxymethylfurfural (5‐HMF) was performed in the three databases PubMed, Web of Science and SciFinder® for six and four Areas, respectively. After combination of the searches from the three databases and removal of the duplicates, the total number of references for the grayanotoxins was 652 and for 5‐HMF Area 1b was 3,862, for Area 2b was 37, for Area 3b was 221 and for Area 4b was 500. The evaluation of all retrieved references for relevance by screening the title and abstract (if available) and applying eligibility criteria (inclusion/exclusion) resulted in a total number of relevant references for the grayanotoxins for Area 1a of 71, for Area 2a of 3, for Area 3a of 5, for Area 4a of 75, for Area 5a of 141, and for Area 6a of 78 and for 5‐HMF for Area 1b of 55, for Area 2b of 14, for Area 3b of 15 and for Area 4b of 8.

The exposure to selected chemical contaminants from fish has been calculated for the Danish population, both for adults (15–75 years of age) and children (4–14 years of age). The Danish mean consumption of fish is 21 g person−1 day−1 for adults and 12 g person−1 day−1 for children. Fish consumption is the main food group contributor for exposure to mercury and dioxins and dioxin-like polychlorinated biphenyls (PCDD/F and DL-PCB) for the Danish population. Comparison of the mean exposure with the TDI or TWI values shows for these substances as well as for perfluorooctane sulphuric acid (PFOS) that the exposure is below the TDI/TWI values. However, even without taking other food groups into account, PCDD/Fs and DL-PCB exposure is close to the actual TWI-value. Calculation of the Margin of Exposure (MOE) for the sum of hexabromocyclododecanes (HBCDD) and polycyclic aromatic hydrocarbons (PAHs) revealed fish consumption to be of low concern for the consumer health regarding these contaminants.

Miljø- og Fødevareministeriets departement vil gerne have DTU Fødevareinstituttets input/kommentarer til SCCS opinion om aluminium i kosmetiske produkter.

De tyske myndigheder har undersøgt et fødevarekontaktmateriale med bivoks til indpakning af fødevarer og fundet afsmitning af to veterinære lægemidler som benyttes til behandling af bier mod varoamider. Der er påvist følgende indhold i migrationstest: Coumaphos 0,030 +/-0,015 mg/L migrat Tau-Fluvalinat: 0,038 +/-0,019 mg/L migrat I den forbindelse har FVST bedt DTU foretage en vurdering af risikoen ved indtag af fødevarer indpakket i indpakningspapiret med bivoks. DTU er specifikt blevet bedt om at inddrage eksperterne i fødevarekontaktmaterialer(FMK) i forhold til vurdering af afsmitning fra FKM.

Background To date, four human bocaviruses (HBoV) have been described. The most closely related viruses (bovine and canine parvoviruses) are associated with miscarriage in their hosts. The objective of this retrospective study was to determine the frequency of HBoV DNA in miscarriage. Study Design Tissue samples from 172 patients, in which miscarriage occurred, were included and tested with a published qPCR protocol. Positive PCRs were mutually confirmed by sequencing. Results 43 patients (25%) were positive for HBoV DNA. Of those, the majority of HBoV-positive samples were tissues from miscarriage (placenta: 6; aborted tissue products of conception: 37 specimens). The samples were not paired; either placental or aborted tissue was available. Conclusions The results show that, as long as no animal model is available, the role of HBoV in the occurrence of miscarriage requires additional prospective studies in order to investigate its significance and causal involvements of this pathogen.

In April 2017, the Organic Business Development Team released a report with 25 recommendations for the Minister of Environment and Food (Det økologiske erhvervsteam 2017). Among these was a recommendation that organic farmers should have opportunities for utilizing nutrients from treated domestic wastewater for nutrient recycling. A prerequisite for future use of nutrients from treated wastewater is, that quality requirements are met and that application can be explained to (and accepted by) consumers. In partial fulfilment of this, the business team identified a need for a scientific overview of the risks of using nutrients from treated municipal wastewater in relation to other authorized fertilizer sources – e.g. conventional animal manures. Thus, it was assumed that a comparative approach to assess potential risk of using sewage sludge and conventional manures, could usefully inform decision makers in the future regulation of organic farming systems. Dependent on the result of the scientific investigation, the Organic Business Development Team foresaw that Denmark could chose to work to expand Annex 1 of the EU Ecology Regulation, to allow the organic farmers to use nutrients from municipal wastewater or other acceptable derived sludge products. Mobilization of support for this should be done by the Ministry of Environment and Food in collaboration with the Organic Farming Industry. Thus, based on available literature, this report aims at creating an overview of the environmental and human risks associated with application of pig and cattle slurry as well as sewage sludge to agricultural soils. The risk evaluation was performed for the following compound groups: Metals, Chlorophenyls, Dioxins, Furans, Halogenated aliphatic and aromatic hydrocarbons (HAH), Linear alkylbenzenesulfonates (LAS), Polyaromatic hydrocarbons (PAH), Polybrominated diphenyl ethers (PBDE), Polychlorinated biphenyls (PCB), Poly- and perfluorinated alkylated substances (PFAS), Phenols, Phosph

During the last decade, the interest on the use of seaweed as food or feed, which was before limited to certain European regional subpopulations, has experienced a significant increase in other regions of the EU. In fact, the growing awareness and interest on sustainable and alternative food sources, healthier lifestyles and changes on dietary patterns brought seaweed to the spotlight for the general worldwide cuisine. Due to their high biosorption and accumulation capacity, seaweed can be an important source of increased exposure to persistent and potential harmful elements, such as cadmium (Cd), lead (Pb), mercury (Hg) and inorganic arsenic (iAs), or even some micronutrients, particularly iodine (I), to which an antioxidant role as been described in seaweed. This concentration potential has raised the interest of several Food Authorities regarding the risk of increased exposure to these elements. Moreover, the European Commission requested the collection of monitoring data on their levels aiming to aid the performance of better risk assessments and potentially set maximum levels on the European Legislation. This work aimed to obtain levels of these elements in species of seaweed (Fucus vesiculosus, Fucus serratus, Fucus spiralis, Fucus evanescens, Saccharina latissima, ulva lactuca and Ccladophora sp.) cultivated and harvested in Denmark, following European Commission's request. Additionally, a collaboration between Denmark, Ireland, France and the Netherlands was initiated to review and collect all the data available on scientific papers regarding the levels of these contaminants in seaweed worldwide. The final result of this work would be the publication of a review article. This Fellowship also provided on-the-job training on the evaluation of applications of new biocides and participation in the science based advises given to the Danish Food and Veterinary Administration, Danish EPA, the Danish Medical Agency and ECHA. (C) 2019 European Food Safety Authority.

Carcinogenic effects in humans are ascribed to processed meat by organisations such as International Agency for Research on Cancer, World Cancer Research Fund and American Institute for Cancer Research. However, the term ‘processed meat’ covers a heterogenic group of products whose content of potential hazards differ considerably. To improve estimates of associations between processed meat intake and cancer risk we investigated ways to divide processed meat into subgroups that more precisely reflects its carcinogenic characteristics. We collected ingredient lists and declarations of salt content for >1000 processed meat products on the Danish market and combined the information with knowledge related to processing parameters. Some compounds that could affect the products' carcinogenic characteristics, alone or in combination, were evaluated and compared for 12 types of processed meat products, and we suggest subgrouping of processed meat with similar level of carcinogenic potential, which could improve the understanding of the cancer risk associated with processed meat intake in scientific human studies.