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1. Impact of smoking in patients with suspected coronary artery disease in the randomised DISCHARGE trial

Author

Mancone, Massimo, Mézquita, Aldo J. Vázquez, Birtolo, Lucia Ilaria, Maurovich-Horvat, Pal, Kofoed, Klaus F., Benedek, Theodora, Donnelly, Patrick, Rodriguez-Palomares, Jose, Erglis, Andrejs, Štěchovský, Cyril, Šakalytė, Gintare, Ađić, Nada Čemerlić, Gutberlet, Matthias, Diez, Ignacio, Davis, Gershan, Zimmermann, Elke, Kępka, Cezary, Vidakovic, Radosav, Francone, Marco, Ilnicka-Suckiel, Małgorzata, Plank, Fabian, Knuuti, Juhanni, Faria, Rita, Schröder, Stephen, Berry, Colin, Saba, Luca, Ruzsics, Balazs, Rieckmann, Nina, Kubiak, Christine, Hansen, Kristian Schultz, Müller-Nordhorn, Jaqueline, Merkely, Bela, Sigvardsen, Per E., Benedek, Imre, Orr, Clare, Valente, Filipa Xavier, Zvaigzne, Ligita, Suchánek, Vojtěch, Jankauskas, Antanas, Ađić, Filip, Woinke, Michael, Keane, Stephen, Lecumberri, Ignacio, Thwaite, Erica, Kruk, Mariusz, Jovanovic, Vladimir, Kuśmierz, Donata, Feuchtner, Gudren, Pietilä, Mikko, Ribeiro, Vasco Gama, Drosch, Tanja, Delles, Christian, Palmisano, Vitanio, Fisher, Michael, Drobni, Zsófia D., Kragelund, Charlotte, Aurelian, Rosca, Kelly, Stephanie, del Blanco, Bruno Garcia, Rubio, Ainhoa, Boussoussou, Melinda, Hove, Jens D., Rodean, Ioana, Regan, Susan, Calabria, Hug Cuéllar, Becker, Dávid, Larsen, Linnea, Hodas, Roxana, Napp, Adriane E., Haase, Robert, Feger, Sarah, Mohamed, Mahmoud, Neumann, Konrad, Dreger, Henryk, Rief, Matthias, Wieske, Viktoria, Douglas, Pamela S., Estrella, Melanie, Bosserdt, Maria, Martus, Peter, Serna-Higuita, Lina M., Dodd, Jonathan D., and Dewey, Marc

Published
2024
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3. Erratum. Computed Tomography Versus Invasive Coronary Angiography in Patients With Diabetes and Suspected Coronary Artery Disease. Diabetes Care 2023;46:2015–2023

Author

Benedek, Theodora, primary, Wieske, Viktoria, additional, Szilveszter, Bálint, additional, Kofoed, Klaus F., additional, Donnelly, Patrick, additional, Rodriguez-Palomares, José, additional, Erglis, Andrejs, additional, Veselka, Josef, additional, Šakalytė, Gintarė, additional, Ađić, Nada Čemerlić, additional, Gutberlet, Matthias, additional, Diez, Ignacio, additional, Davis, Gershan, additional, Zimmermann, Elke, additional, Kępka, Cezary, additional, Vidakovic, Radosav, additional, Francone, Marco, additional, Ilnicka-Suckiel, Małgorzata, additional, Plank, Fabian, additional, Knuuti, Juhani, additional, Faria, Rita, additional, Schröder, Stephen, additional, Berry, Colin, additional, Saba, Luca, additional, Ruzsics, Balazs, additional, Rieckmann, Nina, additional, Kubiak, Christine, additional, Hansen, Kristian Schultz, additional, Müller-Nordhorn, Jacqueline, additional, Merkely, Bela, additional, Sigvardsen, Per E., additional, Benedek, Imre, additional, Orr, Clare, additional, Valente, Filipa Xavier, additional, Zvaigzne, Ligita, additional, Horváth, Martin, additional, Jankauskas, Antanas, additional, Ađić, Filip, additional, Woinke, Michael, additional, Mulvihill, Niall, additional, Lecumberri, Iñigo, additional, Thwaite, Erica, additional, Laule, Michael, additional, Kruk, Mariusz, additional, Stefanovic, Milica, additional, Mancone, Massimo, additional, Kuśmierz, Donata, additional, Feuchtner, Gudrun, additional, Pietilä, Mikko, additional, Ribeiro, Vasco Gama, additional, Drosch, Tanja, additional, Delles, Christian, additional, Melis, Marco, additional, Fisher, Michael, additional, Boussoussou, Melinda, additional, Kragelund, Charlotte, additional, Aurelian, Rosca, additional, Kelly, Stephanie, additional, Blanco, Bruno Garcia del, additional, Rubio, Ainhoa, additional, Károlyi, Mihály, additional, Hove, Jens D., additional, Rodean, Ioana, additional, Regan, Susan, additional, Calabria, Hug Cuéllar, additional, Gellér, László, additional, Larsen, Linnea, additional, Hodas, Roxana, additional, Napp, Adriane E., additional, Haase, Robert, additional, Feger, Sarah, additional, Mohamed, Mahmoud, additional, Serna-Higuita, Lina M., additional, Neumann, Konrad, additional, Dreger, Henryk, additional, Rief, Matthias, additional, Danesh, John, additional, Estrella, Melanie, additional, Bosserdt, Maria, additional, Martus, Peter, additional, Dodd, Jonathan D., additional, and Dewey, Marc, additional

Published
2024
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5. Impact of smoking in patients with suspected coronary artery disease in the randomised DISCHARGE trial

Author

Mancone, Massimo, primary, Mézquita, Aldo J. Vázquez, additional, Birtolo, Lucia Ilaria, additional, Maurovich-Horvat, Pal, additional, Kofoed, Klaus F., additional, Benedek, Theodora, additional, Donnelly, Patrick, additional, Rodriguez-Palomares, Jose, additional, Erglis, Andrejs, additional, Štěchovský, Cyril, additional, Šakalytė, Gintare, additional, Ađić, Nada Čemerlić, additional, Gutberlet, Matthias, additional, Diez, Ignacio, additional, Davis, Gershan, additional, Zimmermann, Elke, additional, Kępka, Cezary, additional, Vidakovic, Radosav, additional, Francone, Marco, additional, Ilnicka-Suckiel, Małgorzata, additional, Plank, Fabian, additional, Knuuti, Juhanni, additional, Faria, Rita, additional, Schröder, Stephen, additional, Berry, Colin, additional, Saba, Luca, additional, Ruzsics, Balazs, additional, Rieckmann, Nina, additional, Kubiak, Christine, additional, Hansen, Kristian Schultz, additional, Müller-Nordhorn, Jaqueline, additional, Merkely, Bela, additional, Sigvardsen, Per E., additional, Benedek, Imre, additional, Orr, Clare, additional, Valente, Filipa Xavier, additional, Zvaigzne, Ligita, additional, Suchánek, Vojtěch, additional, Jankauskas, Antanas, additional, Ađić, Filip, additional, Woinke, Michael, additional, Keane, Stephen, additional, Lecumberri, Ignacio, additional, Thwaite, Erica, additional, Kruk, Mariusz, additional, Jovanovic, Vladimir, additional, Kuśmierz, Donata, additional, Feuchtner, Gudren, additional, Pietilä, Mikko, additional, Ribeiro, Vasco Gama, additional, Drosch, Tanja, additional, Delles, Christian, additional, Palmisano, Vitanio, additional, Fisher, Michael, additional, Drobni, Zsófia D., additional, Kragelund, Charlotte, additional, Aurelian, Rosca, additional, Kelly, Stephanie, additional, del Blanco, Bruno Garcia, additional, Rubio, Ainhoa, additional, Boussoussou, Melinda, additional, Hove, Jens D., additional, Rodean, Ioana, additional, Regan, Susan, additional, Calabria, Hug Cuéllar, additional, Becker, Dávid, additional, Larsen, Linnea, additional, Hodas, Roxana, additional, Napp, Adriane E., additional, Haase, Robert, additional, Feger, Sarah, additional, Mohamed, Mahmoud, additional, Neumann, Konrad, additional, Dreger, Henryk, additional, Rief, Matthias, additional, Wieske, Viktoria, additional, Douglas, Pamela S., additional, Estrella, Melanie, additional, Bosserdt, Maria, additional, Martus, Peter, additional, Serna-Higuita, Lina M., additional, Dodd, Jonathan D., additional, and Dewey, Marc, additional

Published
2023
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7. Age and Computed Tomography and Invasive Coronary Angiography in Stable Chest Pain: A Prespecified Secondary Analysis of the DISCHARGE Randomized Clinical Trial

Author

Bosserdt, Maria, Serna-Higuita, Lina M., Feuchtner, Gudrun, Merkely, Bela, Kofoed, Klaus F., Benedek, Theodora, Donnelly, Patrick, Rodriguez-Palomares, José, Erglis, Andrejs, Štechovský, Cyril, Šakalyte, Gintare, Adic, Nada Cemerlic, Gutberlet, Matthias, Dodd, Jonathan D., Diez, Ignacio, Davis, Gershan, Zimmermann, Elke, Kepka, Cezary, Vidakovic, Radosav, Francone, Marco, Ilnicka-Suckiel, Malgorzata, Plank, Fabian, Knuuti, Juhani, Faria, Rita, Schröder, Stephen, Berry, Colin, Saba, Luca, Ruzsics, Balazs, Rieckmann, Nina, Kubiak, Christine, Hansen, Kristian Schultz, Müller-Nordhorn, Jacqueline, Szilveszter, Bálint, Sigvardsen, Per E., Benedek, Imre, Orr, Clare, Valente, Filipa Xavier, Zvaigzne, Ligita, Suchánek, Vojtech, Jankauskas, Antanas, Adic, Filip, Woinke, Michael, Hensey, Mark, Lecumberri, Iñigo, Thwaite, Erica, Laule, Michael, Kruk, Mariusz, Neskovic, Aleksandar N., Mancone, Massimo, Kusmierz, Donata, Pietilä, Mikko, Ribeiro, Vasco Gama, Drosch, Tanja, Delles, Christian, Porcu, Maurizio, Fisher, Michael, Boussoussou, Melinda, Kragelund, Charlotte, Aurelian, Rosca, Kelly, Stephanie, Garcia del Blanco, Bruno, Rubio, Ainhoa, Maurovich-Horvat, Pál, Hove, Jens D., Rodean, Ioana, Regan, Susan, Cuellar-Calabria, Hug, Molnár, Levente, Larsen, Linnea, Hodas, Roxana, Napp, Adriane E., Haase, Robert, Feger, Sarah, Mohamed, Mahmoud, Neumann, Konrad, Dreger, Henryk, Rief, Matthias, Wieske, Viktoria, Estrella, Melanie, Martus, Peter, Sox, Harold C., and Dewey, Marc

Abstract

IMPORTANCE: The effectiveness and safety of computed tomography (CT) and invasive coronary angiography (ICA) in different age groups is unknown. OBJECTIVE: To determine the association of age with outcomes of CT and ICA in patients with stable chest pain. DESIGN, SETTING, AND PARTICIPANTS: The assessor-blinded Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) randomized clinical trial was conducted between October 2015 and April 2019 in 26 European centers. Patients referred for ICA with stable chest pain and an intermediate probability of obstructive coronary artery disease were analyzed in an intention-to-treat analysis. Data were analyzed from July 2022 to January 2023. INTERVENTIONS: Patients were randomly assigned to a CT-first strategy or a direct-to-ICA strategy. MAIN OUTCOMES AND MEASURES: MACE (ie, cardiovascular death, nonfatal myocardial infarction, or stroke) and major procedure-related complications. The primary prespecified outcome of this secondary analysis of age was major adverse cardiovascular events (MACE) at a median follow-up of 3.5 years. RESULTS: Among 3561 patients (mean [SD] age, 60.1 [10.1] years; 2002 female [56.2%]), 2360 (66.3%) were younger than 65 years, 982 (27.6%) were between ages 65 to 75 years, and 219 (6.1%) were older than 75 years. The primary outcome was MACE at a median (IQR) follow-up of 3.5 (2.9-4.2) years for 3523 patients (99%). Modeling age as a continuous variable, age, and randomization group were not associated with MACE (hazard ratio, 1.02; 95% CI, 0.98-1.07; P for interaction = .31). Age and randomization group were associated with major procedure-related complications (odds ratio, 1.15; 95% CI, 1.05-1.27; P for interaction = .005), which were lower in younger patients. CONCLUSIONS AND RELEVANCE: Age did not modify the effect of randomization group on the primary outcome of MACE but did modify the effect on major procedure-related complications. Results suggest that CT was associated with a lower risk of major procedure-related complications in younger patients. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02400229

Published
2024
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8. CT versus Invasive Coronary Angiography in Patients With Diabetes and Suspected Coronary Artery Disease

Author

Benedek, Theodora, primary, Wieske, Viktoria, primary, Szilveszter, Bálint, primary, Kofoed, Klaus F, primary, Donnelly, Patrick, primary, Rodriguez-Palomares, José, primary, Erglis, Andrejs, primary, Veselka, Josef, primary, Šakalytė, Gintarė, primary, Čemerlić Ađić, Nada, primary, Gutberlet, Matthias, primary, Diez, Ignacio, primary, Davis, Gershan, primary, Zimmermann, Elke, primary, Kępka, Cezary, primary, Vidakovic, Radosav, primary, Francone, Marco, primary, Ilnicka-Suckiel,, Małgorzata, primary, Plank, Fabian, primary, Knuuti, Juhani, primary, Faria, Rita, primary, Schröder, Stephen, primary, Berry, Colin, primary, Saba, Luca, primary, Ruzsics, Balazs, primary, Rieckmann, Nina, primary, Kubiak, Christine, primary, Hansen, Kristian Schultz, primary, Müller-Nordhorn, Jacqueline, primary, Merkely, Bela, primary, Sigvardsen, Per E, primary, Benedek, Imre, primary, Orr, Clare, primary, Xavier Valente, Filipa, primary, Zvaigzne, Ligita, primary, Horváth, Martin, primary, Jankauskas, Antanas, primary, Ađić, Filip, primary, Woinke, Michael, primary, Mulvihill, Niall, primary, Lecumberri, Iñigo, primary, Thwaite, Erica, primary, Laule, Michael, primary, Kruk, Mariusz, primary, Stefanovic, Milica, primary, Mancone, Massimo, primary, Kuśmierz, Donata, primary, Feuchtner, Gudrun, primary, Pietilä, Mikko, primary, Ribeiro, Vasco Gama, primary, Drosch, Tanja, primary, Delles, Christian, primary, Melis, Marco, primary, Fisher, Michael, primary, Boussoussou, Melinda, primary, Kragelund, Charlotte, primary, Aurelian, Rosca, primary, Kelly, Stephanie, primary, del Blanco, Bruno Garcia, primary, Rubio, Ainhoa, primary, Károlyi, Mihály, primary, Hove, Jens D., primary, Rodean, Ioana, primary, Regan, Susan, primary, Cuéllar-Calabria, Hug, primary, Gellér, László, primary, Larsen, Solveig Linnea Veen, primary, Hodas, Roxana, primary, E. Napp, Adriane, primary, Haase, Robert, primary, Feger, Sarah, primary, Mohamed, Mahmoud, primary, M. Serna-Higuita, Lina, primary, Neumann, Konrad, primary, Dreger, Henryk, primary, Rief, Matthias, primary, Danesh, John, primary, Estrella, Melanie, primary, Bosserdt, Maria, primary, Martus, Peter, primary, D. Dodd, Jonathan, primary, and Dewey, Marc, primary

Published
2023
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9. CT or Invasive Coronary Angiography in Stable Chest Pain

Author

Maurovich-Horvat, Pal, Bosserdt, Maria, Kofoed, Klaus F., Rieckmann, Nina, Benedek, Theodora, Donnelly, Patrick, Rodriguez-Palomares, Jose, Erglis, Andrejs, Stechovsk, Cyril, Sakalyte, Gintare, Adic, Nada Cemerlic, Gutberlet, Matthias, Dodd, Jonathan D., Diez, Ignacio, Davis, Gershan, Zimmermann, Elke, Kepka, Cezary, Vidakovic, Radosav, Francone, Marco, Ilnicka-Suckiel, Malgorzata, Plank, Fabian, Knuuti, Juhani, Faria, Rita, Schroder, Stephen, Berry, Colin, Saba, Luca, Ruzsics, Balazs, Kubiak, Christine, Gutierrez-Ibarluzea, Inaki, Hansen, Kristian Schultz, Muller-Nordhorn, Jacqueline, Merkely, Bela, Knudsen, Andreas D., Benedek, Imre, Orr, Clare, Valente, Filipa Xavier, Zvaigzne, Ligita, Suchanek, Vojtech, Zajanckauskiene, Laura, Adic, Flip, Woinke, Michael, Hensey, Mark, Lecumberri, Inigo, Thwaite, Erica, Laule, Michael, Kruk, Mariusz, Neskovic, Aleksandar N., Larsen, Linnea, Jurlander, Birgit, and Engstrom, Thomas

Subjects
ANGINA, MANAGEMENT, PCI, General Medicine, GUIDELINES
Abstract

BACKGROUNDIn the diagnosis of obstructive coronary artery disease (CAD), computed tomography (CT) is an accurate, noninvasive alternative to invasive coronary angiography (ICA). However, the comparative effectiveness of CT and ICA in the management of CAD to reduce the frequency of major adverse cardiovascular events is uncertain.METHODSWe conducted a pragmatic, randomized trial comparing CT with ICA as initial diagnostic imaging strategies for guiding the treatment of patients with stable chest pain who had an intermediate pretest probability of obstructive CAD and were referred for ICA at one of 26 European centers. The primary outcome was major adverse cardiovascular events (cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke) over 3.5 years. Key secondary outcomes were procedure-related complications and angina pectoris.RESULTSAmong 3561 patients (56.2% of whom were women), follow-up was complete for 3523 (98.9%). Major adverse cardiovascular events occurred in 38 of 1808 patients (2.1%) in the CT group and in 52 of 1753 (3.0%) in the ICA group (hazard ratio, 0.70; 95% confidence interval [CI), 0.46 to 1.07; P=0.10). Major procedure-related complications occurred in 9 patients (0.5%) in the CT group and in 33 (1.9%) in the ICA group (hazard ratio, 0.26; 95% CI, 0.13 to 0.55). Angina during the final 4 weeks of follow-up was reported in 8.8% of the patients in the CT group and in 7.5% of those in the ICA group (odds ratio, 1.17; 95% CI, 0.92 to 1.48).CONCLUSIONSAmong patients referred for ICA because of stable chest pain and intermediate pretest probability of CAD, the risk of major adverse cardiovascular events was similar in the CT group and the ICA group. The frequency of major procedure-related complications was lower with an initial CT strategy.

Published
2022

11. Effect of allogeneic adipose tissue‐derived mesenchymal stromal cell treatment in chronic ischaemic heart failure with reduced ejection fraction – the SCIENCE trial.

Author

Qayyum, Abbas Ali, van Klarenbosch, Bas, Frljak, Sabina, Cerar, Andraz, Poglajen, Gregor, Traxler‐Weidenauer, Denise, Nadrowski, Pawel, Paitazoglou, Christina, Vrtovec, Bojan, Bergmann, Martin W., Chamuleau, Steven A. J., Wojakowski, Wojtek, Gyöngyösi, Mariann, Kraaijeveld, Adriaan, Hansen, Kristian Schultz, Vrangbæk, Karsten, Jørgensen, Erik, Helqvist, Steffen, Joshi, Francis Richard, and Johansen, Ellen Mønsted

Subjects
BRAIN natriuretic factor, STROMAL cells, HEART failure, VENTRICULAR ejection fraction, ADIPOSE tissue diseases, CARDIAC patients
Abstract

Aims: The aim of the SCIENCE trial was to investigate whether a single treatment with direct intramyocardial injections of adipose tissue‐derived mesenchymal stromal cells (CSCC_ASCs) was safe and improved cardiac function in patients with chronic ischaemic heart failure with reduced ejection fraction (HFrEF). Methods and results: The study was a European multicentre, double‐blind, placebo‐controlled phase II trial using allogeneic CSCC_ASCs from healthy donors or placebo (2:1 randomization). Main inclusion criteria were New York Heart Association (NYHA) class II–III, left ventricular ejection fraction (LVEF) <45%, and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) levels >300 pg/ml. CSCC_ASCs or placebo (isotonic saline) were injected directly into viable myocardium. The primary endpoint was change in left ventricular end‐systolic volume (LVESV) at 6‐month follow‐up measured by echocardiography. A total of 133 symptomatic HFrEF patients were included. The treatment was safe without any drug‐related severe adverse events or difference in cardiac‐related adverse events during a 3‐year follow‐up period. There were no significant differences between groups during follow‐up in LVESV (0.3 ± 5.0 ml, p = 0.945), nor in secondary endpoints of left ventricular end‐diastolic volume (−2.0 ± 6.0 ml, p = 0.736) and LVEF (−1.6 ± 1.0%, p = 0.119). The NYHA class improved slightly within the first year in both groups without any difference between groups. There were no changes in 6‐min walk test, NT‐proBNP, C‐reactive protein or quality of life the first year in any groups. Conclusion: The SCIENCE trial demonstrated safety of intramyocardial allogeneic CSCC_ASC therapy in patients with chronic HFrEF. However, it was not possible to improve the pre‐defined endpoints and induce restoration of cardiac function or clinical symptoms. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Willingness to Pay and Preferences Among Patients Undergoing Cystoscopies: Results from a Large Survey-Based Study in Spain.

Author

Brugés, Cindy N Borja, Rindorf, Dinah K, Cepeda, Marcos, and Hansen, Kristian Schultz

Subjects
WILLINGNESS to pay, PATIENT preferences, CYSTOSCOPY, PATIENTS' attitudes, COVID-19 pandemic, MEDICAL care
Abstract

Purpose: Cystoscopy procedures can cause distress among patients. Patient perspectives on health services are essential inputs in decision-making. This study investigated the patient preferences in Spain regarding single-use cystoscopes (SUC) compared to reusable cystoscopes and their willingness to pay (WTP) for cystoscopy procedures. Patients and Methods: Between May and June 2021, an anonymous survey was distributed to Spanish patients who had previously undergone a cystoscopy. The survey included patient preference measures on reusable cystoscopes compared to SUCs and a discrete choice experiment. The survey was distributed through a human data science company (IQVIA), collected using an online survey tool (QuestionPro®), and analyzed using Stata/MP, StataCorp. Results: Of 300 respondents, 148 (49.33%) were female and 150 (50%) were male, and mainly between 18– 49 years (247, 82.33%). Most (265, 88%) preferred to have their procedure performed with a SUC rather than a reusable cystoscope. Among these patients, 215 (80%) could imagine asking their doctor to use a SUC. A total of 231 (77%) respondents indicated an increased level of concern about the risk of exposure to contamination related to their cystoscopy following the COVID-19 pandemic. Patients would pay 62 EUR to have their initial consultation and cystoscopy procedure on the same day (p <  0.001), 59 EUR to reduce the environmental impact, and 57 EUR to reduce the risk of contamination (p <  0.001). Conclusion: Patients prefer to undergo cystoscopy using an SUC on the same day as their initial consultation. The increased contamination concerns due to the COVID-19 pandemic and WTP to reduce the risk of cystoscope contamination may explain patients' preferences for SUCs. The most important attributes related to their cystoscopy procedure are the ability to have their procedure performed on the same day as their initial consultation, the reduction of the environmental impact, and the reduction of the contamination risk. [ABSTRACT FROM AUTHOR]

Published
2022
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14. Conceptualising equity in the impact evaluation of chronic disease management programmes: a capabilities approach.

Author

Tapager, Ina, Hansen, Kristian Schultz, and Vrangbæk, Karsten

Abstract

Chronic diseases are highly important for the future level and distribution of health and well-being in western societies. Consequently, it seems pertinent to assess not only efficiency of chronic care but also its impact on health equity. However, operationalisation of health equity has proven a challenging task. Challenges include identifying a relevant and measurable evaluative space. Various schools of thought in health economics have identified different outcomes of interest for equity assessment, with capabilities as a proposed alternative to more conventional economic conceptualisations. The aim of this paper is to contribute to the conceptualisation of health equity evaluation in the context of chronic disease management. We do this by firstly introducing an equity enquiry framework incorporating the capabilities approach. Secondly, we demonstrate the application and relevance of this framework through a content analysis of equity-related principles and aims in national chronic disease management guidelines and the national diabetes action plan in Denmark. Finally, we discuss how conceptualisations of equity focused on capabilities may be used in evaluation by scoping relevant operationalisations. A promising way forward in the context of chronic care evaluation may emerge from a combination of concepts of capabilities developed in economics, health sciences and psychology. [ABSTRACT FROM AUTHOR]

Published
2022
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21. Coronary Artery Calcium Score Predicts Major Adverse Cardiovascular Events in Stable Chest Pain

Author

Biavati, Federico, Saba, Luca, Boussoussou, Melinda, Kofoed, Klaus F., Benedek, Theodora, Donnelly, Patrick, Rodríguez-Palomares, José, Erglis, Andrejs, Štěchovský, Cyril, Šakalytė, Gintarė, Čemerlić Ađić, Nada, Gutberlet, Matthias, Dodd, Jonathan D., Diez, Ignacio, Davis, Gershan, Zimmermann, Elke, Kępka, Cezary, Vidakovic, Radosav, Francone, Marco, Ilnicka-Suckiel, Małgorzata, Plank, Fabian, Knuuti, Juhani, Faria, Rita, Schröder, Stephen, Berry, Colin, Ruzsics, Balazs, Rieckmann, Nina, Kubiak, Christine, Hansen, Kristian Schultz, Müller-Nordhorn, Jacqueline, Maurovich-Horvat, Pál, Sigvardsen, Per E., Benedek, Imre, Orr, Clare, Valente, Filipa Xavier, Zvaigzne, Ligita, Suchánek, Vojtěch, Jankauskas, Antanas, Ađić, Filip, Woinke, Michael, Cadogan, Diarmaid, Lecumberri, Iñigo, Thwaite, Erica, Kruk, Mariusz, Neskovic, Aleksandar N., Mancone, Massimo, Kuśmierz, Donata, Feuchtner, Gudrun, Pietilä, Mikko, Ribeiro, Vasco Gama, Drosch, Tanja, Delles, Christian, Cau, Riccardo, Fisher, Michael, Merkely, Bela, Kragelund, Charlotte, Aurelian, Rosca, Kelly, Stephanie, Blanco, Bruno García del, Rubio, Ainhoa, Szilveszter, Bálint, Hove, Jens D., Rodean, Ioana, Regan, Susan, Cuéllar Calabria, Hug, Édes, István Ferenc, Larsen, Linnea, Hodas, Roxana, Napp, Adriane E., Haase, Robert, Feger, Sarah, Mohamed, Mahmoud, Serna-Higuita, Lina M., Neumann, Konrad, Dreger, Henryk, Rief, Matthias, Wieske, Viktoria, Budoff, Matthew J., Estrella, Melanie, Martus, Peter, Bosserdt, Maria, and Dewey, Marc

Abstract

In participants with stable chest pain referred for invasive coronary angiography, those with a coronary artery calcium score of 0 at CT had very low, while higher scores had increasing occurrence of major adverse cardiovascular events.

Published
2024
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22. Effect of Body Mass Index on Effectiveness of CT versus Invasive Coronary Angiography in Stable Chest Pain: The DISCHARGE Trial

Author

Sykes, Robert, Collison, Damien, Merkely, Bela, Kofoed, Klaus F., Donnelly, Patrick, Rodríguez-Palomares, José, Erglis, Andrejs, Veselka, Josef, Šakalytė, Gintarė, Ađić, Nada Čemerlić, Gutberlet, Matthias, Dodd, Jonathan D., Diez, Ignacio, Davis, Gershan, Zimmermann, Elke, Kępka, Cezary, Vidakovic, Radosav, Francone, Marco, Ilnicka-Suckiel, Małgorzata, Plank, Fabian, Knuuti, Juhani, Faria, Rita, Schröder, Stephen, Berry, Colin, Saba, Luca, Ruzsics, Balazs, Rieckmann, Nina, Kubiak, Christine, Hansen, Kristian Schultz, Müller-Nordhorn, Jacqueline, Maurovich-Horvat, Pál, Knudsen, Andreas D., Benedek, Imre, Orr, Clare, Valente, Filipa Xavier, Zvaigzne, Ligita, Horváth, Martin, Jankauskas, Antanas, Ađić, Filip, Woinke, Michael, Keane, Stephen, Lecumberri, Iñigo, Thwaite, Erica, Laule, Michael, Kruk, Mariusz, Zivanic, Aleksandra, Mancone, Massimo, Kuśmierz, Donata, Feuchtner, Gudrun, Pietilä, Mikko, Ribeiro, Vasco Gama, Drosch, Tanja, Delles, Christian, Porcu, Michele, Fisher, Michael, Bárány, Tamás, Sørum, Charlotte, Aurelian, Rosca, Kelly, Stephanie, Blanco, Bruno Garcia del, Rubio, Ainhoa, Szilveszter, Bálint, Abdulla, Jawdat, Rodean, Ioana, Regan, Susan, Calabria, Hug Cuéllar, Vecsey-Nagy, Milán, Jurlander, Birgit, Hodas, Roxana, Feger, Sarah, Mohamed, Mahmoud, Serna-Higuita, Lina M., Neumann, Konrad, Dreger, Henryk, Rief, Matthias, Wieske, Viktoria, Ferencik, Maros, Estrella, Melanie, Bosserdt, Maria, Martus, Peter, Benedek, Theodora, and Dewey, Marc

Abstract

When patients suspected of having coronary artery disease were stratified by body mass index category, no difference in clinical outcomes was observed between those who underwent initial management with CT and those who underwent invasive coronary angiography.

Published
2024
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25. Cost-effectiveness analysis of the national implementation of integrated community case management and community-based health planning and services in Ghana for the treatment of malaria, diarrhoea and pneumonia

Author

Escribano Ferrer, Blanca, primary, Hansen, Kristian Schultz, additional, Gyapong, Margaret, additional, Bruce, Jane, additional, Narh Bana, Solomon A., additional, Narh, Clement T., additional, Allotey, Naa-Korkor, additional, Glover, Roland, additional, Azantilow, Naa-Charity, additional, Bart-Plange, Constance, additional, Sagoe-Moses, Isabella, additional, and Webster, Jayne, additional

Published
2017
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27. Cost-Effectiveness Analysis of Test-Based versus Presumptive Treatment of Uncomplicated Malaria in Children under Five Years in an Area of High Transmission in Central Ghana

Author

Tawiah, Theresa, primary, Hansen, Kristian Schultz, additional, Baiden, Frank, additional, Bruce, Jane, additional, Tivura, Mathilda, additional, Delimini, Rupert, additional, Amengo-Etego, Seeba, additional, Chandramohan, Daniel, additional, Owusu-Agyei, Seth, additional, and Webster, Jayne, additional

Published
2016
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30. Cost-effectiveness analyses of self-harm strategies aimed at reducing the mortality of pesticide self-poisonings in Sri Lanka: a study protocol.

Author

Madsen, Lizell Bustamante, Eddleston, Michael, Hansen, Kristian Schultz, Pearson, Melissa, Agampodi, Suneth, Jayamanne, Shaluka, and Konradsen, Flemming

Abstract

Introduction: An estimated 803 900 people worldwide died as a result of self-harm in 2012. The deliberate ingestion of pesticides has been identified as the method most frequently used to commit fatal self-harm globally. In Sri Lanka, it is estimated that up to 60% of all suicides are committed using this method. The aim of the present study is to assess the cost-effectiveness of an ongoing safe storage intervention currently taking place in a rural Sri Lankan district and to model the cost-effectiveness of implementing the safe storage intervention as well as four potential interventions (legislative, medical management, follow-up contact and mobile phone contact) on a national level. Methods and analysis: Study design for all the strategies is a cost-effectiveness analysis. A governmental perspective is adopted. The time horizon for tracking the associated costs and health outcomes of the safe storage intervention on district level runs over 3 years. The time horizon is extended to 5 years when modelling a full national roll-out of the respective interventions. The discounting of costs and health outcomes are undertaken at the recommended real rate of 3%. Threshold analyses of the modelled strategies are employed to assess the strategies potential for cost-effectiveness, running scenarios with health outcome improvements ranging from 1% to 100%. Sensitivity analyses are also performed. The main outcome measures of the safe storage intervention are incremental cost-effectiveness ratios. Ethics and dissemination: Ethical approval was granted for the safe storage project from the University of Peradeniya, Sri Lanka, in March of 2008. An amendment for the present study was granted from Rajarata University of Sri Lanka in November of 2013. Findings will be disseminated to public and private stakeholders in local and national government in Sri Lanka as well as the wider academic audience through peer-reviewed publications and international conferences. [ABSTRACT FROM AUTHOR]

Published
2015
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31. The labor market costs of work-related stress: A longitudinal study of 52 763 Danish employees using multi-state modeling.

Author

Pedersen J, Graversen BK, Hansen KS, and Madsen IEH

Subjects
Male, Humans, Female, Longitudinal Studies, Denmark, Unemployment, Occupational Stress epidemiology, Psychological Tests, Self Report
Abstract

Objective: Work-related stress is an important public health concern in all industrialized countries and is linked to reduced labor market affiliation and an increased disease burden. We aimed to quantify the labor market costs of work-related stress for a large sample of Danish employees., Methods: We linked four consecutive survey waves on occupational health and five national longitudinal registers with date-based information on wage and social benefits payments. From 2012 to 2020, we followed survey participants for two year-periods, yielding 110 559 person-years. We identified work stress by combining three dichotomous stress indicators: (i) self-perceived work stress, (ii) Cohen 4-level perceived stress scale, and (iii) job strain. Using the multi-state expected labor market affiliation (ELMA) method, we estimated the labor market expenses associated with work-related stress., Results: Of the employees, 26-37% had at least one work-stress indicator. Men aged 35-64 years and women aged 18-64 years with work-related stress had up to 81.6 fewer workdays and up to 50.7 more days of sickness absence during follow-up than similarly aged men without work stress. The average annual work absenteeism loss per employee linked to work-related stress was €1903 for men and €3909 for women, corresponding to 3.3% of men's average annual wages and 9.0% of women's average annual wages, respectively. The total annual expenses were €305.2 million for men and €868.5 million for women., Conclusion: Work-related stress was associated with significant labor market costs due to increased sickness absence and unemployment. The prevention of work-related stress is an important occupational health concern, and the development of effective interventions should be given high priority.

Published
2024
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