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Your search keyword '"Han, Ji-bo"' showing total 11 results
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11 results on '"Han, Ji-bo"'

7. Occurrence and predictive risk factors associated with in-stent restenosis after drug-eluting stent implantation in diabetic patients: a prospective, clinical cohort study

Author

Zhao, ShengGang, primary, Xu, Jian-Jiang, additional, Jiang, Li-Qin, additional, Chu, Zhen-Liang, additional, Tao, An-Qian, additional, Jin, Lei, additional, Han, Ji-Bo, additional, Zhang, Bin, additional, Zheng, Zhan-Xiong, additional, Shi, Feng-Jie, additional, Zhang, Ran, additional, Zhang, Xiang-Yu, additional, Jiang, Fen-Fen, additional, and Han, Bing-Jiang, additional

Published
2020
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10. Increased Levels of Systolic Blood Pressure Within the Normal Range Are Associated With Significantly Elevated Risks of Nonalcoholic Fatty Liver Disease

Author

Wu, Sheng-Jie, Zou, Hai, Zhu, Gui-Qi, Wang, Li-Ren, Zhang, Qi, Shi, Ke-Qing, Han, Ji-Bo, Huang, Wei-Jian, Braddock, Martin, Chen, Yong-Ping, and Zheng, Ming-Hua

Abstract

A positive association between hypertension or high-normal blood pressure (BP) and risk of nonalcoholic fatty liver disease (NAFLD) is well-known; however, no data have been generated exploring the risk of NAFLD within the normal range of BP. We aimed to assess the association between normal systolic blood pressure (SBP) and risk of NAFLD.

Published
2015
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11. LncRNA FAM225A activates the cGAS-STING signaling pathway by combining FUS to promote CENP-N expression and regulates the progression of nasopharyngeal carcinoma.

Author

Han JB, Wang Y, Yang R, Xu Y, Li F, and Jia Y

Subjects
Cell Line, Tumor, Cell Movement genetics, Cell Proliferation genetics, Chromosomal Proteins, Non-Histone metabolism, Epithelial-Mesenchymal Transition genetics, Gene Expression Regulation, Neoplastic genetics, Humans, Membrane Proteins metabolism, Nasopharyngeal Carcinoma genetics, Nasopharyngeal Carcinoma pathology, Nucleotidyltransferases genetics, Nucleotidyltransferases metabolism, RNA-Binding Protein FUS genetics, Signal Transduction, Nasopharyngeal Neoplasms pathology, RNA, Long Noncoding genetics, RNA, Long Noncoding metabolism
Abstract

Background: Nasopharyngeal carcinoma (NPC) is a common malignant tumor and long non-coding RNAs (lncRNAs) are widely involved in NPC development. Nevertheless, the role of lncRNA FAM225A in NPC remain unclear. Here, we evaluated the effect of FAM225A on NPC cell proliferation, migration and epithelial-mesenchymal transition (EMT)., Methods: Levels of FAM225A and CENP-N in NPC tissues and cells were measured using RT-qPCR. Western blot assessed CENP-N, Snail, E-cadherin, N-cadherin, Vimentin, cGAS and p-STING levels. FAM225A expression was knocked down by sh-FAM225A or overexpressed by pcDNA-FAM225A. RIP and RNA pull-down verified the binding between FAM225A, CENP-N and FUS. Cell proliferation, migration and invasion were evaluated by CCK8, colony formation and transwell assays., Results: FAM225A and CENP-N expression levels were evaluated in NPC tissues and cell lines. FAM225A knockdown inhibited NPC cell proliferation, migration and EMT. FAM225A stabilized CENP-N mRNA by recruiting FUS. FAM225A activated cGAS-STING by regulating the expression of CENP-N to promote NPC cell proliferation, migration and EMT., Conclusion: FAM225A regulates NPC progression via FUS/CENP-N mediated cGAS-STING signaling pathway, which provides new therapeutic targets for developing new NPC treatments., (Copyright © 2022 Elsevier GmbH. All rights reserved.)

Published
2022
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