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Background Left ventricular remodeling (LVR) in patients with ST-segment elevation myocardial infarction (STEMI) may lead to poor prognosis in which circulating exosome miRNAs play a critical role. The aim of the present study is to identify specific exosome miRNAs for LVR in patients with STEMI. Method Plasma exosome miRNAs were assessed in 20 patients (90% male, mean age of 66.95±1.65 years) 3–6 months after STEMI and 24 healthy individuals (83% male, mean age of 33.2±0.93 years) by using qPCR. Of the 20 patients, 8 had post-STEMI LVR according to echocardiographic evaluation, and the others did not. Clinical biochemical data including total cholesterol, HDL-C, LDL-C, LDH and NT-pro-BNP were collected from the patients with STEMI at same time as exosome miRNAs assessment. Specific exosome miRNAs for LVR were identified by using qPCR. Correlations between the dysregulated exosome miRNAs and the clinical biochemical parameters in patients with STEMI were analyzed using spearman correlation test. Results Five exosome miRNAs including hsa-miR-181a-3p (p Conclusions Circulating exosome miR-181a-3p and let-7d-3p might play a potential role in LVR in patients 3–6 months after STEMI. Exosome hsa-miR-874-3p might be associated with cardiomyocyte injury. Hsa-miR-23a-3p and hsa-miR-224-5p demonstrated an activity in regulation of lipid metabolism and biosynthesis in patients with STEMI. Funding Acknowledgement Type of funding sources: Public hospital(s). Main funding source(s): This work was supported by grants from the 3×3 Clinical Scientist Fund of Sun Yat-sen Memorial Hospital

循环肿瘤DNA（ctDNA）是液体活检代表性指标之一，近年来在肿瘤诊治中的价值备受关注。ctDNA临床研究涉及的方向包括伴随诊断、疗效预测、预后判断、耐药监测、免疫治疗等。随着相关临床研究的开展，ctDNA逐渐从基础走向临床应用。本文回顾近期ctDNA临床研究进展，介绍新的观点及研究思路，探讨ctDNA临床研究瓶颈及前景。.

A function polymer is considered to be a kind of potential Enhanced Oil Recovery (EOR) agent that can further enhance oil recovery after polymer flooding. Based on the typical geologic features and development history of the Daqing Oilfield, a function polymer displacement experiment was conducted using a 3D laboratory physical model with a high-permeability channel between the injection end and the production end to study the EOR mechanism of the function polymer solution. In this article, the displacement feature and oil/water distribution of function polymer flooding is presented, as well as the swept effect in pores of different sizes. The experimental results show that the function polymer flooding after regular polymer flooding further enhances oil recovery by 10.29%. Moreover, the increment of sweep efficiency and displacement efficiency reaches 3.02% and 11.78%, respectively, which clearly demonstrates that the function polymer system improves the displacement efficiency by the emulsificat...

An association between Candida and oral cancer has long been discussed in the literature and in particular Candida albicans has been proposed to play a significant role in the development of oral cancer. Although this organism is a common member of the oral mucosa and can cause a variety of oral mucosal lesions, the exact mechanisms by which C. albicans potentially causes the development of malignant disease still require much research. We have undertaken an extensive literature search to understand pathogenicity of C. albicans, including its virulence factors, its interactions with the host immune, how a dysregulation of the immune response can result in malignancy, and how a potential C. albicans specific cytokine response may be involved in oral carcinogenesis. We present here a candid assessment of the role of Candida in oral carcinogenesis and a hypothetical model about how this may occur. Finally, we present potential future research which is necessary to elucidate this role.

The ultrarapid underpass (URUP) tunneling method, in which a shield machine is launched and received at the ground surface level, has been developed for tunneling in congested areas. This p...

Olfactory dysfunction is one of the common diseases in the Department of Otorhinolaryngology. Although the olfactory nerve has ability to regenerate in human central nervous system, if the damage involves nerve, only a few patients can restore the olfactory function. At present, there is no satisfactory treatment for sensorineural olfactory dysfunction. Therefore, it is urgent to explore new and effective method for treating sensorineural olfactory dysfunction. The progress of stem cells in the treatment of olfactory dysfunction is reviewed in this article.

To analyze the clinical characteristics, outcome and diagnosis of two cases of imported children Zika virus infection in China.A retrospective analysis was performed on clinical characteristics, treatment and outcome of two cases of imported children with Zika virus infection in February 2016 in Enping People's Hospital of Guangdong.Two cases of children with imported Zika virus infection resided in an affected area of Venezuela, 8-year-old girl and her 6 year-old brother. The main findings on physical examination included the following manifestations: fever, rash, and conjunctivitis. The rash was first limited to the abdomen, but extended to the torso, neck and face, and faded after 3-4 d. The total number of white blood cells was not high and liver function was normal. The diagnosis of two cases of Zika virus infection was confirmed by the expert group of Guangdong Provincial Center for Disease Control and Prevention, according to the epidemiological history, clinical manifestations and Zika virus nucleic acid detection results.Treatment of Zika virus infection involves supportive care. Two Zika virus infection children had a relatively benign outcome.At present, Zika virus infection in children is an imported disease in China. No specific therapy is available for this disease. Information on long-term outcomes among infants and children with Zika virus disease is limited, routine pediatric care is advised for these infants and children.

To study the characteristics of blood lipids levels' change during pregnancy, and to discuss the relationships between the blood lipid level and the age, gestational hypertension, gestational diabetes and other pregnancy complications.From January to September 2015, we enrolled 2 907 pregnant women admitted to our hospital for regular checks as control group, 190 cases in gestational hypertension group, 258 cases in gestational diabetes mellitus group. The control group was divided into first trimester (≤12 w) second trimester (20 to 26 w) and third trimester (≥28 w) groups; in second trimester group, patients were further divided into the certain age group (35years old) and elderly group (≥35 years old); blood lipid levels including serum levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) were detected in all groups.(1) Blood lipids levels varied as pregnancy proceeded. TG level increased most significantly, followed by TC, LDL-C level. However, HDL-C level slightly decreased in third trimester comparing with first and second trimester stage, the difference was statistically significant (P0.05); (2) serum TC, TG and LDL-C level in second trimester were significantly higher in the certain age group than in the elder group (P0.05); (3) in gestational diabetes mellitus group, serum TC, TG, LDL-C levels were significantly higher in first and second trimester than those in the control group (P0.05); (4) in gestational hypertension group, serum TC, TG, LDL-C levels were significantly higher in third trimester than those in the control group (P0.05); HDL-C level was lower in the gestational hypertension group than in the control group, and there was statistically significant difference (P0.05).The blood lipid levels in pregnancy increase gradually as the gestational weeks increase, which can be explained as a normal physiological phenomenon. Elder pregnancy, gestational hypertension and gestational diabetes mellitus patients usually have obvious blood lipid disorder, therefore, it is very important to monitor the blood lipid level during pregnancy stages for predicting and early intervention of pregnancy complications such as gestational diabetes mellitus and gestational hypertension.

To evaluate the hemodynamics of maxillary artery (MA), superficial temporal artery (STA) and ophthalmic artery (OA), and evaluate the hemodynamics prediction capability of these arteries formed compensatory arteries into intracranial using Doppler ultrasonography.The evaluation of MA, STA, and OA with transcranial doppler ultrasonography and with cerebral angiography was made in 106 MMD patients (total of 212 hemispheres of the brain), 58 male and 48 female, aged 39.3±12.0 years old. Doppler ultrasonography measured the following blood flow parameters: peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistance index (RI). DSA evaluate whether MA, STA, OA formed compensatory arteries into intracranial. Based on the compensation situation, the patients were divided into two groups: compensatory group and non-compensatory group. The differences of patient's hemodynamic parameters between compensatory and non-compensatory groups were performed using independent two-sample t-tests with equal or non-equal variance as appropriate. Categorical variables were summarized using frequency and percentage and compared using Chi-square tests. We evaluated the prediction ability of each hemodynamic parameters for each artery (combining left and right side) using Receiver Operating Curve. All the analyses were performed using SAS 9.4 (Cary, NC).Comparing the hemodynamic parameters between the compensatory group and non-compensatory group, all hemodynamic parameters of MA, STA and OA have statistically significant differences between the two groups. Depending on the ROC Curve, EDV (AUC=0.6933±0.0463) for MA, RI (AUC=0.8910±0.0569) for STA, EDV (AUC=0.7863± 0.0330) for OA are better predictors of compensatory growth.Color duplex ultrasonography is a reliable, noninvasive and economic tool to assess hemodynamic changes of MA, STA and OA, and has prediction capability of these arteries formed compensatory arteries into intracranial.

Activation of hepatic stellate cells (HSCs) plays an important role in the development of liver fibrosis. The eukaryotic translation initiation factor (eIF) 3a is the largest subunit of the eIF3 complex and has been involved in pulmonary fibrosis. However, the role of eIF3a in liver fibrosis remains largely unknown. Therefore, in this study, we investigated the role of eIF3a in transforming growth factor-β1 (TGF-β1)-induced HSC activation. Our results demonstrated that the expression of eIF3a was up-regulated in human liver fibrotic tissues and activated HSCs. In addition, knockdown of eIF3a suppressed TGF-β-induced HSC proliferation and the expression of α-smooth muscle actin (α-SMA) and collagen I. Furthermore, knockdown of eIF3a inhibited the expression of p-Smad3 induced by TGF-β1 in HSCs. These results suggest that eIF3a may function as a novel regulator to modulate HSC activation, potentially through inhibiting the TGF-β1/Smad3 signaling pathway.

Acute otitis externa(AOE) is defined as diffuse inflammation of the external ear canal skin or subdermis occurred in 3 weeks,which sometimes may also involve the pinna or tympanic membrane.Clinical manifestations include:otalgia,itching,fullness,sometimes with hearing loss.The hallmark sign of AOE is tenderness with movement of the tragus or pinna AOE Often occurs in adults or children older than age of 2,while little morbidity in children under the age of 2.Lifetime incidence is up to 10% in a persons life.Recently,a lot of different versions of the AOE clinical practice guidelines were published abroad.In this review ,the etiology,diagnose,therapy,prevention,are comprehensive described,which on the basis of evidence-based medicine.

An newborn boy showed multiple skin lumps at birth. On examination, there were disseminated red cobblestone-like skin neoplasms, 5-30mm in diameter with hard serosanguineous crust, some were with scabs, over the scalp, face, trunk and extremities (Fig. 1A,B). The liver was 3 cm palpable below the costal margin. He was active and stable. The mother’ prenatal investigation on antibodies of rubella, herpes simplex virus (HSV) and hepatitis B surface antigen were positive. The baby's antibodies for HAV, HBV, HCV, rubella, HSV, HIV and syphilis were negative. Blood cultures were negative. However, his condition deteriorated on the 10th day, presented as poor circulation and respiratory distress. This article is protected by copyright. All rights reserved.