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Hydro distilled essential oil of the aerial parts of Caryopteris incana harvested from Zhejiang province, China was analyzed by gas chromatography-mass spectrometry (GC/MS). Thirty-nine components ...

This paper is an application of the Internet of Things in campus power generation system. The electricity generated by people riding bicycles can be regarded as a kind of green energy generation. Fitness bikes are set up at every point on the campus. Each fitness bike is equipped with a generator. The development board will be connected to the generator. The generator is equipped with voltage and current sensors. LoRa modules are installed on every fitness bike on campus. These nodes will send the data to the LoRa Gateway of each campus through wireless transmission, and finally the LoRa Gateway will store the data on the cloud server through Ethernet wired transmission.

Long non-coding RNAs (lncRNAs) have been reported to biologically regulate tumor progression. LncRNA MIR31HG has been identified as an oncogene in several cancer types, but its role and mechanism in glioblastoma (GBM) remain to be explored. In the present study, we detected strongly-expressed MIR31HG in GBM cells through RT-qPCR analysis. Through loss-of-function assays, we uncovered that MIR31HG exerted its oncogenic property in GBM through boosting cell proliferation and suppressing the apoptosis. Mechanistically, STAT1 was found to be as a transcription factor and played a part in activating the transcription of MIR31HG with upregulating the expression of MIR31HG in GBM. Moreover, high MIR31HG level was confirmed to induce the activation of Wnt/β-catenin signaling pathway in a variety of cancers. From subcellular fractionation and western blot assays, it was displayed that MIR31HG activated Wnt/β-catenin signaling pathway through enhancing the nuclear translocation of β-catenin. Rescue assays showed that the treatment of LiCl countervailed MIR31HG depletion-induced inhibition on GBM cell growth. In conclusion, STAT1-induced upregulation of lncRNA MIR31HG facilitates GBM cell growth by activating Wnt/β-catenin signaling pathway.

Background: Emerging studies have attested that long noncoding RNAs (lncRNAs) predominantly functioned in carcinogenesis of multiple developing human tumors. The current research aimed at probing the underlying participation and mechanisms of LINC00337 in lung adenocarcinoma.Methods: Here we analyzed TCGA and GTEx datasets and chose LINC00337 as research object. Cell proliferation, cell apoptosis, cell cycle, and invasion were detected in gain and loss experiment of LINC00337 both in vitro and in vivo. Moreover, RNA pull-down, luciferase reporter assays, western blotting analysis, rescue experiment were performed to investigate underlying molecular mechanisms of LINC00337 function. Results: LINC00337 was remarkably increased in lung adenocarcinoma. Also, LINC00337 knock-down was unraveled to repress cell invasion and proliferation as well as cell cycle, and gear up apoptosis in lung adenocarcinoma in vitro and in vivo. With respect to mechanism, LINC00337 knock-down boosted miR-1285-3p to be expressed and then restrained YTHDF1 to be expressed post-transcriptionally. Crucially, both miR-1285-3p decrement and YTHDF1 overexpression successfully countered the influence on cell proliferation, invasion and apoptosis caused by LINC00337 shRNA.Conclusions: These results suggest that LINC00337 acted as an oncogenic lncRNA, targeting miR-1285-3p and regulating YTHDF1 expression, to promote the progression of lung adenocarcinoma.

A new type of chiral tertiary amine ligand was designed and derived from l -proline and ( R )-BINOL. These new chiral ligands chelated with Cu(II) showed highly catalytic efficiency in enantioselective Henry reactions. Excellent yields (up to 99%) and high enantioselectivities (up to 96% ee) were achieved for aromatic, hetero-aromatic and aliphatic aldehyde substrates, without an additional base additive or the need for air or moisture exclusion.

We report the synthesis and characterization of a series of novel C3h-symmetric 2,4,6-tris(2-hydroxyphenyl)-1,3,5-triazine (THPT) derivatives. These compounds possess an interesting intramolecular hydrogen bonding pattern, which leads to the planarization between the triazine ring and the pendant aryl groups. The enhanced π-stacking interaction, resulting from the planarization, facilitates the column formation. Two of them exhibit a columnar hexagonal phase (Colh) over a wide temperature range induced by strong intramolecular hydrogen bonds.

A new type of chiral tertiary amine ligand was designed and derived from l -proline and ( R )-BINOL. These new chiral ligands chelated with Cu(II) showed highly catalytic efficiency in enantioselective Henry reactions. Excellent yields (up to 99%) and high enantioselectivities (up to 96% ee) were achieved for aromatic, hetero-aromatic and aliphatic aldehyde substrates, without an additional base additive or the need for air or moisture exclusion.