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10,363 results on '"Guo, C."'

1. Benchmarking the design of the cryogenics system for the underground argon in DarkSide-20k

Author: Collaboration, DarkSide-20k, Acerbi, F., Adhikari, P., Agnes, P., Ahmad, I., Albergo, S., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Amaudruz, P., Angiolilli, M., Aprile, E., Ardito, R., Corona, M. Atzori, Auty, D. J., Ave, M., Avetisov, I. C., Azzolini, O., Back, H. O., Balmforth, Z., Olmedo, A. Barrado, Barrillon, P., Batignani, G., Bhowmick, P., Blua, S., Bocci, V., Bonivento, W., Bottino, B., Boulay, M. G., Buchowicz, A., Bussino, S., Busto, J., Cadeddu, M., Cadoni, M., Calabrese, R., Camillo, V., Caminata, A., Canci, N., Capra, A., Caravati, M., Cárdenas-Montes, M., Cargioli, N., Carlini, M., Castellani, A., Castello, P., Cavalcante, P., Cebrian, S., Ruiz, J. Cela, Chashin, S., Chepurnov, A., Cifarelli, L., Cintas, D., Citterio, M., Cleveland, B., Coadou, Y., Cocco, V., Colaiuda, D., Vilda, E. Conde, Consiglio, L., Costa, B. S., Czubak, M., D'Aniello, M., D'Auria, S., Rolo, M. D. Da Rocha, Darbo, G., Davini, S., De Cecco, S., De Guido, G., Dellacasa, G., Derbin, A. V., Devoto, A., Di Capua, F., Di Ludovico, A., Di Noto, L., Di Stefano, P., Dias, L. K., Mairena, D. Díaz, Ding, X., Dionisi, C., Dolganov, G., Dordei, F., Dronik, V., Elersich, A., Ellingwood, E., Erjavec, T., Diaz, M. Fernandez, Ficorella, A., Fiorillo, G., Franchini, P., Franco, D., Gatti, H. Frandini, Frolov, E., Gabriele, F., Gahan, D., Galbiati, C., Galiński, G., Gallina, G., Gallus, G., Garbini, M., Abia, P. Garcia, Gawdzik, A., Gendotti, A., Ghisi, A., Giovanetti, G. K., Casanueva, V. Goicoechea, Gola, A., Grandi, L., Grauso, G., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guerzoni, M., Gulino, M., Guo, C., Hackett, B. R., Hallin, A., Hamer, A., Haranczyk, M., Harrop, B., Hessel, T., Hill, S., Horikawa, S., Hu, J., Hubaut, F., Hucker, J., Hugues, T., Hungerford, E. V., Ianni, A., Ippolito, V., Jamil, A., Jillings, C., Jois, S., Kachru, P., Keloth, R., Kemmerich, N., Kemp, A., Kendziora, C. L., Kimura, M., Kish, A., Kondo, K., Korga, G., Kotsiopoulou, L., Koulosousas, S., Kubankin, A., Kunzé, P., Kuss, M., Kuźniak, M., Kuzwa, M., La Commara, M., Lai, M., Guirriec, E. Le, Leason, E., Leoni, A., Lidey, L., Lissia, M., Luzzi, L., Lychagina, O., Macfadyen, O., Machulin, I. N., Manecki, S., Manthos, I., Mapelli, L., Marasciulli, A., Mari, S. M., Mariani, C., Maricic, J., Martinez, M., Martoff, C. J., Matteucci, G., Mavrokoridis, K., McDonald, A. B., Mclaughlin, J., Merzi, S., Messina, A., Milincic, R., Minutoli, S., Mitra, A., Moharana, A., Moioli, S., Monroe, J., Moretti, E., Morrocchi, M., Mroz, T., Muratova, V. N., Murphy, M., Murra, M., Muscas, C., Musico, P., Nania, R., Nessi, M., Nieradka, G., Nikolopoulos, K., Nikoloudaki, E., Nowak, J., Olchanski, K., Oleinik, A., Oleynikov, V., Organtini, P., de Solórzano, A. Ortiz, Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Papi, D., Pastuszak, G., Paternoster, G., Peck, A., Pegoraro, P. A., Pelczar, K., Pellegrini, L. A., Perez, R., Perotti, F., Pesudo, V., Piacentini, S. I., Pino, N., Plante, G., Pocar, A., Poehlmann, M., Pordes, S., Pralavorio, P., Price, D., Puglia, S., Bazetto, M. Queiroga, Ragusa, F., Ramachers, Y., Ramirez, A., Ravinthiran, S., Razeti, M., Renshaw, A. L., Rescigno, M., Retiere, F., Rignanese, L. P., Rivetti, A., Roberts, A., Roberts, C., Rogers, G., Romero, L., Rossi, M., Rubbia, A., Rudik, D., Sabia, M., Salomone, P., Samoylov, O., Sandford, E., Sanfilippo, S., Santone, D., Santorelli, R., Santos, E. M., Savarese, C., Scapparone, E., Schillaci, G., Schuckman II, F. G., Scioli, G., Semenov, D. A., Shalamova, V., Sheshukov, A., Simeone, M., Skensved, P., Skorokhvatov, M. D., Smirnov, O., Smirnova, T., Smith, B., Sotnikov, A., Spadoni, F., Spangenberg, M., Stefanizzi, R., Steri, A., Stornelli, V., Stracka, S., Sulis, S., Sung, A., Sunny, C., Suvorov, Y., Szelc, A. M., Taborda, O., Tartaglia, R., Taylor, A., Taylor, J., Tedesco, S., Testera, G., Thieme, K., Thompson, A., Thorpe, T. N., Tonazzo, A., Torres-Lara, S., Tricomi, A., Unzhakov, E. V., Vallivilayil, T. J., Van Uffelen, M., Velazquez-Fernandez, L., Viant, T., Viel, S., Vishneva, A., Vogelaar, R. B., Vossebeld, J., Vyas, B., Wada, M., Walczak, M. B., Wang, H., Wang, Y., Westerdale, S., Williams, L., Wojaczyński, R., Wojcik, M., Wojcik, M. M., Wright, T., Xiao, X., Xie, Y., Yang, C., Yin, J., Zabihi, A., Zakhary, P., Zani, A., Zhang, Y., Zhu, T., Zichichi, A., Zuzel, G., and Zykova, M. P.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: DarkSide-20k (DS-20k) is a dark matter detection experiment under construction at the Laboratori Nazionali del Gran Sasso (LNGS) in Italy. It utilises ~100 t of low radioactivity argon from an underground source (UAr) in its inner detector, with half serving as target in a dual-phase time projection chamber (TPC). The UAr cryogenics system must maintain stable thermodynamic conditions throughout the experiment's lifetime of >10 years. Continuous removal of impurities and radon from the UAr is essential for maximising signal yield and mitigating background. We are developing an efficient and powerful cryogenics system with a gas purification loop with a target circulation rate of 1000 slpm. Central to its design is a condenser operated with liquid nitrogen which is paired with a gas heat exchanger cascade, delivering a combined cooling power of >8 kW. Here we present the design choices in view of the DS-20k requirements, in particular the condenser's working principle and the cooling control, and we show test results obtained with a dedicated benchmarking platform at CERN and LNGS. We find that the thermal efficiency of the recirculation loop, defined in terms of nitrogen consumption per argon flow rate, is 95 % and the pressure in the test cryostat can be maintained within $\pm$(0.1-0.2) mbar. We further detail a 5-day cool-down procedure of the test cryostat, maintaining a cooling rate typically within -2 K/h, as required for the DS-20k inner detector. Additionally, we assess the circuit's flow resistance, and the heat transfer capabilities of two heat exchanger geometries for argon phase change, used to provide gas for recirculation. We conclude by discussing how our findings influence the finalisation of the system design, including necessary modifications to meet requirements and ongoing testing activities., Comment: 45 pages, 24 figures
Published: 2024

2. DarkSide-20k sensitivity to light dark matter particles

Author: Collaboration, DarkSide-20k, Acerbi, F., Adhikari, P., Agnes, P., Ahmad, I., Albergo, S., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Amaudruz, P., Angiolilli, M., Aprile, E., Ardito, R., Corona, M. Atzori, Auty, D. J., Ave, M., Avetisov, I. C., Azzolini, O., Back, H. O., Balmforth, Z., Olmedo, A. Barrado, Barrillon, P., Batignani, G., Bhowmick, P., Blua, S., Bocci, V., Bonivento, W., Bottino, B., Boulay, M. G., Buchowicz, A., Bussino, S., Busto, J., Cadeddu, M., Cadoni, M., Calabrese, R., Camillo, V., Caminata, A., Canci, N., Capra, A., Caravati, M., Cárdenas-Montes, M., Cargioli, N., Carlini, M., Castellani, A., Castello, P., Cavalcante, P., Cebrian, S., Ruiz, J. M. Cela, Chashin, S., Chepurnov, A., Cifarelli, L., Cintas, D., Citterio, M., Cleveland, B., Coadou, Y., Cocco, V., Colaiuda, D., Vilda, E. Conde, Consiglio, L., Costa, B. S., Czubak, M., D'Aniello, M., D'Auria, S., Rolo, M. D. Da Rocha, Darbo, G., Davini, S., De Cecco, S., De Guido, G., Dellacasa, G., Derbin, A. V., Devoto, A., Di Capua, F., Di Ludovico, A., Di Noto, L., Di Stefano, P., Dias, L. K., Mairena, D. Díaz, Ding, X., Dionisi, C., Dolganov, G., Dordei, F., Dronik, V., Elersich, A., Ellingwood, E., Erjavec, T., Diaz, M. Fernandez, Ficorella, A., Fiorillo, G., Franchini, P., Franco, D., Gatti, H. Frandini, Frolov, E., Gabriele, F., Gahan, D., Galbiati, C., Galiński, G., Gallina, G., Gallus, G., Garbini, M., Abia, P. Garcia, Gawdzik, A., Gendotti, A., Ghisi, A., Giovanetti, G. K., Casanueva, V. Goicoechea, Gola, A., Grandi, L., Grauso, G., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guerzoni, M., Gulino, M., Guo, C., Hackett, B. R., Hallin, A., Hamer, A., Haranczyk, M., Harrop, B., Hessel, T., Hill, S., Horikawa, S., Hu, J., Hubaut, F., Hucker, J., Hugues, T., Hungerford, E. V., Ianni, A., Ippolito, V., Jamil, A., Jillings, C., Jois, S., Kachru, P., Keloth, R., Kemmerich, N., Kemp, A., Kendziora, C. L., Kimura, M., Kondo, K., Korga, G., Kotsiopoulou, L., Koulosousas, S., Kubankin, A., Kunzé, P., Kuss, M., Kuźniak, M., Kuzwa, M., La Commara, M., Lai, M., Guirriec, E. Le, Leason, E., Leoni, A., Lidey, L., Lissia, M., Luzzi, L., Lychagina, O., Macfadyen, O., Machulin, I. N., Manecki, S., Manthos, I., Mapelli, L., Marasciulli, A., Mari, S. M., Mariani, C., Maricic, J., Martinez, M., Martoff, C. J., Matteucci, G., Mavrokoridis, K., McDonald, A. B., Mclaughlin, J., Merzi, S., Messina, A., Milincic, R., Minutoli, S., Mitra, A., Moioli, S., Monroe, J., Moretti, E., Morrocchi, M., Mroz, T., Muratova, V. N., Murphy, M., Murra, M., Muscas, C., Musico, P., Nania, R., Nessi, M., Nieradka, G., Nikolopoulos, K., Nikoloudaki, E., Nowak, J., Olchanski, K., Oleinik, A., Oleynikov, V., Organtini, P., de Solórzano, A. Ortiz, Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Papi, D., Pastuszak, G., Paternoster, G., Peck, A., Pegoraro, P. A., Pelczar, K., Pellegrini, L. A., Perez, R., Perotti, F., Pesudo, V., Piacentini, S. I., Pino, N., Plante, G., Pocar, A., Poehlmann, M., Pordes, S., Pralavorio, P., Price, D., Puglia, S., Bazetto, M. Queiroga, Ragusa, F., Ramachers, Y., Ramirez, A., Ravinthiran, S., Razeti, M., Renshaw, A. L., Rescigno, M., Retiere, F., Rignanese, L. P., Rivetti, A., Roberts, A., Roberts, C., Rogers, G., Romero, L., Rossi, M., Rubbia, A., Rudik, D., Sabia, M., Salomone, P., Samoylov, O., Sandford, E., Sanfilippo, S., Santone, D., Santorelli, R., Santos, E. M., Savarese, C., Scapparone, E., Schillaci, G., Schuckman II, F. G., Scioli, G., Semenov, D. A., Shalamova, V., Sheshukov, A., Simeone, M., Skensved, P., Skorokhvatov, M. D., Smirnov, O., Smirnova, T., Smith, B., Sotnikov, A., Spadoni, F., Spangenberg, M., Stefanizzi, R., Steri, A., Stornelli, V., Stracka, S., Sulis, S., Sung, A., Sunny, C., Suvorov, Y., Szelc, A. M., Taborda, O., Tartaglia, R., Taylor, A., Taylor, J., Tedesco, S., Testera, G., Thieme, K., Thompson, A., Tonazzo, A., Torres-Lara, S., Tricomi, A., Unzhakov, E. V., Vallivilayil, T. J., Van Uffelen, M., Velazquez-Fernandez, L., Viant, T., Viel, S., Vishneva, A., Vogelaar, R. B., Vossebeld, J., Vyas, B., Walczak, M. B., Wang, Y., Wang, H., Westerdale, S., Williams, L., Wojaczyński, R., Wojcik, M., Wojcik, M. M., Wright, T., Xie, Y., Yang, C., Yin, J., Zabihi, A., Zakhary, P., Zani, A., Zhang, Y., Zhu, T., Zichichi, A., Zuzel, G., and Zykova, M. P.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The dual-phase liquid argon time projection chamber is presently one of the leading technologies to search for dark matter particles with masses below 10 GeV/c$^2$. This was demonstrated by the DarkSide-50 experiment with approximately 50 kg of low-radioactivity liquid argon as target material. The next generation experiment DarkSide-20k, currently under construction, will use 1,000 times more argon and is expected to start operation in 2027. Based on the DarkSide-50 experience, here we assess the DarkSide-20k sensitivity to models predicting light dark matter particles, including Weakly Interacting Massive Particles (WIMPs) and sub-GeV/c$^2$ particles interacting with electrons in argon atoms. With one year of data, a sensitivity improvement to dark matter interaction cross-sections by at least one order of magnitude with respect to DarkSide-50 is expected for all these models. A sensitivity to WIMP--nucleon interaction cross-sections below $1\times10^{-42}$ cm$^2$ is achievable for WIMP masses above 800 MeV/c$^2$. With 10 years exposure, the neutrino fog can be reached for WIMP masses around 5 GeV/c$^2$., Comment: submitted to Nature Communications
Published: 2024

3. The Belle II Detector Upgrades Framework Conceptual Design Report

Author: Aihara, H., Aloisio, A., Auguste, D. P., Aversano, M., Babeluk, M., Bahinipati, S., Banerjee, Sw., Barbero, M., Baudot, J., Beaubien, A., Becherer, F., Bergauer, T., Bernlochner., F. U., Bertacchi, V., Bertolone, G., Bespin, C., Bessner, M., Bettarini, S., Bevan, A. J., Bhuyan, B., Bona, M., Bonis, J. F., Borah, J., Bosi, F., Boudagga, R., Bozek, A., Bračko, M., Branchini, P., Breugnon, P., Browder, T. E., Buch, Y., Budano, A., Campajola, M., Casarosa, G., Cecchi, C., Chen, C., Choudhury, S., Corona, L., de Marino, G., De Nardo, G., De Pietro, G., de Sangro, R., Dey, S., Dingfelder, J. C., Dong, T. V., Dorokhov, A., Dujany, G., Epifanov, D., Federici, L., Ferber, T., Fillinger, T., Finck, Ch., Finocchiaro, G., Forti, F., Frey, A., Friedl, M., Gabrielli, A., Gaioni, L., Gao, Y., Gaudino, G., Gaur, V., Gaz, A., Giordano, R., Giroletti, S., Gobbo, B., Godang, R., Haide, I., Han, Y., Hara, K., Hayasaka, K., Hearty, C., Heidelbach, A., Higuchi, T., Himmi, A., Hoferichter, M., Howgill, D. A., Hu-Guo, C., Iijima, T., Inami, K., Irmler, C., Ishikawa, A., Itoh, R., Iyer, D., Jacobs, W. W., Jaffe, D. E., Jin, Y., Junginger, T., Kandra, J., Kojima, K., Koga, T., Korobov, A. A., Korpar, S., Križan, P., Krüger, H., Kuhr, T., Kumar, A., Kumar, R ., Kuzmin, A., Kwon, Y. -J., Lacaprara, S., Lacasta, C., Lai, Y. -T., Lalwani, K., Lam, T., Lanceri, L., Lee, M. J., Leonidopoulos, C., Levit, D., Lewis, P. M., Libby, J. F., Liu, Q. Y., Liu, Z. Y., Liventsev, D., Longo, S., Mancinelli, G., Manghisoni, M., Manoni, E., Marinas, C., Martellini, C., Martens, A., Massa, M., Massaccesi, L., Mawas, F., Mazorra, J., Merola, M., Miller, C., Minuti, M., Mizuk, R., Modak, A., Moggi, A., Mohanty, G. B., Moneta, S., Muller, Th., Na, I., Nakamura, K. R., Nakao, M., Natochii, A., Niebuhr, C., Nishida, S., Novosel, A., Pangaud, P., Parker, B., Passeri, A., Pedlar, T. K., Peinaud, Y., Peng, Y., Peschke, R., Pestotnik, R., Pham, T. H., Piccolo, M., Piilonen, L. E., Prell, S., Purohit, M. V., Ratti, L., Re, V., Reuter, L., Riceputi, E., Ripp-Baudot, I., Rizzo, G., Roney, J. M., Russo, A., Sandilya, S., Santelj, L., Savinov, V., Scavino, B., Schall, L., Schnell, G., Schwanda, C., Schwartz, A. J., Schwenker, B., Schwickardi, M., Seljak, A., Serrano, J., Shiu, J. -G., Shwartz, B., Simon, F., Soffer, A., Song, W. M., Starič, M., Stavroulakis, P., Stefkova, S., Stroili, R., Tanaka, S., Taniguchi, N., Teotia, V., Tessema, N., Thalmeier, R., Torassa, E., Trabelsi, K., Trantou, F. F., Traversi, G., Urquijo, P., Vahsen, S. E., Valin, I., Varner, G. S., Varvell, K. E., Vitale, L., Vobbilisetti, V., Wang, X. L., Wessel, C., Wienands, H. U., Won, E., Xu, D., Yamada, S., Yin, J. H., Yoshihara, K., Yuan, C. Z., Zani, L., Zong, Z., and Zou, S.
Subjects: High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: We describe the planned near-term and potential longer-term upgrades of the Belle II detector at the SuperKEKB electron-positron collider operating at the KEK laboratory in Tsukuba, Japan. These upgrades will allow increasingly sensitive searches for possible new physics beyond the Standard Model in flavor, tau, electroweak and dark sector physics that are both complementary to and competitive with the LHC and other experiments., Comment: Editor: F. Forti 170 pages
Published: 2024

4. A new hybrid gadolinium nanoparticles-loaded polymeric material for neutron detection in rare event searches

Author: Collaboration, DarkSide-20k, Acerbi, F., Adhikari, P., Agnes, P., Ahmad, I., Albergo, S., Albuquerque, I. F., Alexander, T., Alton, A. K., Amaudruz, P., Angiolilli, M., Aprile, E., Ardito, R., Corona, M. Atzori, Auty, D. J., Ave, M., Avetisov, I. C., Azzolini, O., Back, H. O., Balmforth, Z., Olmedo, A. Barrado, Barrillon, P., Batignani, G., Bhowmick, P., Bocci, V., Bonivento, W., Bottino, B., Boulay, M. G., Buchowicz, A., Bussino, S., Busto, J., Cadeddu, M., Cadoni, M., Calabrese, R., Camillo, V., Caminata, A., Canci, N., Capra, A., Caravati, M., Cárdenas-Montes, M., Cargioli, N., Carlini, M., Castellani, A., Castello, P., Cavalcante, P., Cavallo, D., Cebrian, S., Ruiz, J. Cela, Chashin, S., Chepurnov, A., Cifarelli, L., Cintas, D., Citterio, M., Cleveland, B., Coadou, Y., Cocco, V., Colaiuda, D., Vilda, E. Conde, Consiglio, L., Costa, B. S., Czubak, M., D'Auria, S., Rolo, M. D. Da Rocha, Darbo, G., Davini, S., De Cecco, S., De Guido, G., Dellacasa, G., Derbin, A. V., Devoto, A., Di Capua, F., Di Ludovico, A., Di Noto, L., Di Stefano, P., Dias, L. K., Mairena, D. Díaz, Ding, X., Dionisi, C., Dolganov, G., Dordei, F., Dronik, V., Elersich, A., Ellingwood, E., Erjavec, T., Diaz, M. Fernandez, Ficorella, A., Fiorillo, G., Franchini, P., Franco, D., Gatti, H. Frandini, Frolov, E., Gabriele, F., Gahan, D., Galbiati, C., Galinski, G., Gallina, G., Garbini, M., Abia, P. Garcia, Gawdzik, A., Gendotti, A., Ghisi, A., Giovanetti, G. K., Casanueva, V. Goicoechea, Gola, A., Grandi, L., Grauso, G., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guerzoni, M., Gulino, M., Guo, C., Hackett, B. R., Hallin, A., Hamer, A., Haranczyk, M., Harrop, B., Hessel, T., Hill, S., Horikawa, S., Hu, J., Hubaut, F., Hucker, J., Hugues, T., Hungerford, E. V., Ianni, A., Ippolito, V., Jamil, A., Jillings, C., Keloth, R., Kemmerich, N., Kemp, A., Kendziora, C. L., Kimura, M., Kondo, K., Korga, G., Kotsiopoulou, L., Koulosousas, S., Kubankin, A., Kuss, M., Kuzniak, M., Kuzwa, M., La Commara, M., Lai, M., Guirriec, E. Le, Leason, E., Leoni, A., Lidey, L., Lissia, M., Luzzi, L., Lychagina, O., Macfadyen, O., Machulin, I. N., Manecki, S., Manthos, I., Mapelli, L., Marasciulli, A., Mari, S. M., Mariani, C., Maricic, J., Marini, A., Martinez, M., Martoff, C. J., Matteucci, G., Mavrokoridis, K., McDonald, A. B., Mclaughlin, J., Merzi, S., Messina, A., Milincic, R., Minutoli, S., Mitra, A., Moharana, A., Moioli, S., Monroe, J., Moretti, E., Morrocchi, M., Mroz, T., Muratova, V. N., Murphy, M., Murra, M., Muscas, C., Musico, P., Nania, R., Nessi, M., Nieradka, G., Nikolopoulos, K., Nikoloudaki, E., Nowak, J., Olchanski, K., Oleinik, A., Oleynikov, V., Organtini, P., de Solórzano, A. Ortiz, Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Papi, D., Pastuszak, G., Paternoster, G., Peddis, D., Pegoraro, P. A., Pelczar, K., Pellegrini, L. A., Perez, R., Perotti, F., Pesudo, V., Piacentini, S. I., Pino, N., Plante, G., Pocar, A., Poehlmann, M., Pordes, S., Pralavorio, P., Price, D., Puglia, S., Bazetto, M. Queiroga, Ragusa, F., Ramachers, Y., Ramirez, A., Ravinthiran, S., Razeti, M., Renshaw, A. L., Rescigno, M., Retiere, F., Rignanese, L. P., Rivetti, A., Roberts, A., Roberts, C., Rogers, G., Romero, L., Rossi, M., Rubbia, A., Rudik, D., Sabia, M., Sadashivajois, S., Salomone, P., Samoylov, O., Sandford, E., Sanfilippo, S., Santone, D., Santorelli, R., Santos, E. M., Savarese, C., Scapparone, E., Schillaci, G., Schuckman II, F. G., Scioli, G., Semenov, D. A., Sheshukov, A., Simeone, M., Skensved, P., Skorokhvatov, M. D., Slimani, S., Smirnov, O., Smirnova, T., Smith, B., Sotnikov, A., Spadoni, F., Spangenberg, M., Stefanizzi, R., Steri, A., Stornelli, V., Stracka, S., Sulis, S., Sung, A., Sunny, C., Suvorov, Y., Szelc, A. M., Taborda, O., Tartaglia, R., Taylor, A., Taylor, J., Tedesco, S., Testera, G., Thieme, K., Thompson, A., Tonazzo, A., Torres-Lara, S., Tosi, S., Tricomi, A., Unzhakov, E. V., Vallivilayil, T. J., Van Uffelen, M., Velazquez-Fernandez, L., Viant, T., Vicini, S., Viel, S., Vishneva, A., Vogelaar, R. B., Vossebeld, J., Vyas, B., Wada, M., Walczak, M. B., Wang, H., Wang, Y., Westerdale, S., Williams, L., Wojaczynski, R., Wojcik, M. M., Wojcik, M., Wright, T., Xie, Y., Yang, C., Yin, J., Zabihi, A., Zakhary, P., Zani, A., Zhang, Y., Zhu, T., Zichichi, A., Zuzel, G., and Zykova, M. P.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Experiments aimed at direct searches for WIMP dark matter require highly effective reduction of backgrounds and control of any residual radioactive contamination. In particular, neutrons interacting with atomic nuclei represent an important class of backgrounds due to the expected similarity of a WIMP-nucleon interaction, so that such experiments often feature a dedicated neutron detector surrounding the active target volume. In the context of the development of DarkSide-20k detector at INFN Gran Sasso National Laboratory (LNGS), several R&D projects were conceived and developed for the creation of a new hybrid material rich in both hydrogen and gadolinium nuclei to be employed as an essential element of the neutron detector. Thanks to its very high cross-section for neutron capture, gadolinium is one of the most widely used elements in neutron detectors, while the hydrogen-rich material is instrumental in efficiently moderating the neutrons. In this paper results from one of the R&Ds are presented. In this effort the new hybrid material was obtained as a poly(methyl methacrylate) (PMMA) matrix, loaded with gadolinium oxide in the form of nanoparticles. We describe its realization, including all phases of design, purification, construction, characterization, and determination of mechanical properties of the new material.
Published: 2024
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5. Development of low-radon ultra-pure water for the Jiangmen Underground Neutrino Observatory

Author: Guan, T. Y., Zhang, Y. P., Wang, B., Guo, C., Liu, J. C., Tang, Q., Yang, C. G., and Li, C.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The Jiangmen Underground Neutrino Observatory(JUNO) is a state-of-the-art liquid scintillator-based neutrino physics experiment under construction in South China. To reduce the background from external radioactivities, a water Cherenkov detector composed of 35~kton ultra-pure water and 2,400 20-inch photomultiplier tubes is developed. Even after specialized treatment, ultra-pure water still contains trace levels of radioactive elements that can contribute to the detector background. Among which $^{222}$Rn is particularly significant. To address this, an online radon removal system based on the JUNO prototype has been developed. By integrating micro-bubble generators to enhance degasser's radon removal efficiency, the radon concentration in water can be reduced to 1~mBq/m$^{3}$ level, meeting the stringent requirements of JUNO. Additionally, a highly sensitive online radon concentration measurement system capable of detecting concentrations $\sim$1~mBq/m$^3$ has been developed to monitor the radon concentration in water. In this paper, the details regarding both systems will be presented., Comment: 20 pages, 13 figures
Published: 2024

6. Developing a $\mu$Bq/m$^{3}$ level $^{226}$Ra concentration in water measurement system for the Jiangmen Underground Neutrino Observatory

Author: Li, C., Wang, B., Liu, Y., Guo, C., Zhang, Y. P., Liu, J. C., Tang, Q., Guan, T. Y., and Yang, C. G.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The Jiangmen Underground Neutrino Observatory (JUNO), a 20~kton multi-purpose low background Liquid Scintillator (LS) detector, was proposed primarily to determine the neutrino mass ordering. To suppress the radioactivity from the surrounding rocks and tag cosmic muons, the JUNO central detector is submerged in a Water Cherenkov Detector (WCD). In addition to being used in the WCD, ultrapure water is used in LS filling, for which the $^{226}$Ra concentration in water needs to be less than 50~$\mu$Bq/m$^3$. To precisely measure the $^{226}$Ra concentration in water, a 6.0~$\mu$Bq/m$^3$ $^{226}$Ra concentration in water measurement system has been developed. In this paper, the detail of the measurement system as well as the $^{226}$Ra concentration measurement result in regular EWII ultrapure water will be presented., Comment: 16 pages, 7 figures
Published: 2024

7. Characterization of pure-NaI crystal with SiPM readout at low temperatures

Author: Xie, X. L., Liang, X. H., Guo, C., Sun, X. L., Wang, L., and Chen, Y. D.
Published: 2024
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8. Insulin-Loaded Graphene Oxide Microparticles: Synthesis, Characterization, Insulin Delivery, and Physical Interactions Analysis

Author: Huang, W. B., Huang, X. Y., Mu, R., Pei, T., Guo, C. P., and Bai, X. Q.
Published: 2024
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9. A study of liquid argon detector’s n/γ discrimination capability with PMT or SiPM readout

Author: Chen, Y. D., Lei, Y., Wang, L., Guan, M. Y., Wang, T. A., Guo, C., Liu, J. C., Yang, C. G., and Liang, X. H.
Published: 2024
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10. Recovery of terephthalic acid from alkali-decrement wastewater by zinc salt-based coagulation

Author: Zhu, H., Guo, C., Xu, C., He, Y., Huang, M., Zhou, G., and Lin, Y.
Published: 2024
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11. Spectroscopy of 187Tl: shape coexistence

Author: Guo, C. Y., Zhang, W. Q., Huang, H., Zhang, S. Q., Li, Z. H., Liu, Z., Hua, H., Luo, D. W., Wu, H. Y., Andreyev, A. N., Seweryniak, D., Andel, B., Antalic, S., Barzakh, A. E., Block, M., Bronis, A., Carpenter, M. P., Copp, P., Cubiss, J. G., Doherty, D. T., Van Duppen, P., Favier, Z., Giacoppo, F., Kindler, B., Kondev, F. G., Lauritsen, T., Li, X. Q., Lommel, B., Al Monthery, M., Mošať, P., Ni, L., Raison, C., Reviol, W., Savard, G., Stolze, S., Wilson, G. L., Xu, C., Zhang, J. Z., Zhang, S. Y., and Zhou, Z. X.
Published: 2024
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12. Association of Admission Hyperglycemia with Clinical Outcomes in Patients with Symptomatic Intracranial Hemorrhage After Endovascular Treatment for Large Vessel Occlusive Stroke

Author: Yan J, Huang J, Pu T, Song J, Yang J, Li L, Li F, Zi W, Guo C, and Peng Z
Subjects: stroke, large vessel occlusion, endovascular treatment, symptomatic intracranial hemorrhage, hyperglycemia, Geriatrics, RC952-954.6
Abstract: Jie Yan,1,&ast; Jiandi Huang,2,&ast; Tianqiang Pu,3,&ast; Jiaxing Song,2 Jie Yang,2 Linyu Li,2 Fengli Li,2 Wenjie Zi,2 Changwei Guo,2 Zhouzhou Peng2 1Department of Neurology, The First People’s Hospital of Yongzhou City, Yongzhou City, Hunan Province, People’s Republic of China; 2Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University, Chongqing City, People’s Republic of China; 3Department of Neurology, The Central Hospital of Guangyuan City, Guangyuan City, Sichuan Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhouzhou Peng; Changwei Guo, Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University, Shapingba District, Chongqing City, People’s Republic of China, Email peng_zhouzhou@163.com; changwei_guo@163.comBackground: Symptomatic intracranial hemorrhage (sICH) is a fatal complication after endovascular treatment (EVT) for acute large vessel occlusive (LVO) stroke. The aim of this study was to investigate the association between hyperglycemia and outcomes in patients with postprocedural sICH.Methods: Of the 2567 patients with AIS who underwent EVT from two large multicenter randomized trials and two prospective multicenter registry studies, 324 patients occurred sICH with documented admission glucose were included in this study. The primary outcome was functional independence (defined as a modified Rankin Scale score of 0 to 2) at 90 days. Secondary outcomes included mRS score of 0 to 3, 0 to 1, and mRS score at 90 days. Safety outcome was the mortality within 90 days. Admission hyperglycemia was defined as a plasma blood glucose ≥ 7.8 mmol/L (140 mg/dL) in our analysis.Results: Of 324 eligible participants included in this study, hyperglycemia was observed in 130 (40.1%) patients. The median age was 67 (IQR, 58– 75) years, and median blood glucose level was 7.1 (IQR, 6.0– 9.3) mmol/L. After adjusting for confounding variables, admission hyperglycemia was associated with decreased odds of functional independence (adjusted odds ratio[OR] 0.34; 95% CI 0.17– 0.68; P= 0.003), decreased odds of favorable outcome (adjusted OR 0.31; 95% CI 0.16– 0.58; P < 0.001) and increased odds of mortality (adjusted OR 2.56; 95% CI 1.47– 4.45; P = 0.001) at 90 days. After 1:1 propensity score matching analysis, the results were consistent with multivariable logistic regression analysis.Conclusion: In patients who suffered sICH after EVT for acute large vessel occlusive stroke, hyperglycemia is a strong predictor of poor clinical outcome and mortality at 90 days.Keywords: stroke, large vessel occlusion, endovascular treatment, symptomatic intracranial hemorrhage, hyperglycemia
Published: 2024

13. Early Conversion of Intensive Insulin Therapy to IDegLira Demonstrates Higher Efficacy and Safety in Reducing Fasting Blood Glucose and HbA1c in T2DM Patients

Author: Guo C and Lu Y
Subjects: insulin intensive therapy, ideglira, t2dm, early conversion, safety, Specialties of internal medicine, RC581-951
Abstract: Caiyun Guo, Yang Lu Department of Endocrinology, YuYao People’s Hospital, Ningbo, Zhejiang Province, People’s Republic of ChinaCorrespondence: Caiyun Guo, Department of Endocrinology, YuYao People’s Hospital, 800 Chengdong Road, Ningbo, Zhejiang Province, 315400, People’s Republic of China, Email guocaiyun9112@163.comBackground: A short-term insulin intensive therapy is an important method used in clinical practice to control blood glucose, and a scientific post-treatment plan is key to long-term blood glucose stability control. This study aimed to investigate efficacy and safety of early conversion of intensive insulin therapy to IDegLira in T2DM patients.Methods: This study was a prospective study, involving 80 T2DM patients finally. Patients were firstly treated with insulin for intensified therapy (Pre-IDegLira group), then switched to insulin degludec and liraglutide (IDegLira) for 3 months (IDegLira-3 months group). Data including HbA1c, fasting blood glucose, fasting C-peptide, weight, insulin dosage, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were analyzed. Correlations between fasting blood glucose and other parameters were evaluated with Pearson correlation analysis.Results: IDegLira early conversion significantly reduced fasting blood glucose (p< 0.001), weight (p=0.015), and insulin dosage (p=0.001) of T2DM patients compared to those of Pre-IDegLira group. HbA1c level was remarkably lower in T2DM patients underwent IDegLira early conversion compared to that in Pre-IDegLira group (p< 0.001), with HbA1c < 7% proportion of 73.75% (59/80). IDegLira early conversion significantly downregulated levels of TC (p< 0.001), TG (p< 0.001), LDL-C (p< 0.001), and upregulated HDL-C level (p=0.017) of T2DM patients, compared to those in Pre-IDegLira group. IDegLira early conversion markedly reduced ALT (p< 0.001) and AST (p=0.002) levels of T2DM patients compared to those in Pre-IDegLira group. IDegLira early conversion demonstrated a positive correlation between fasting blood glucose and HbA1c (r=0.531, p< 0.001) or TG level (r=0.336, p=0.002) in T2DM patients.Conclusion: Early conversion of intensive insulin therapy to IDegLira effectively reduced fasting blood glucose and HbA1c in T2DM patients with higher safety.Keywords: insulin intensive therapy, IDegLira, T2DM, early conversion, safety
Published: 2024

14. Treatment Outcomes and Associated Influencing Factors Among Patients with Rifampicin-Resistant Tuberculosis: A Multicenter, Retrospective, Cohort Study in China

Author: Zou L, Kang W, Guo C, Du J, Chen Q, Shi Z, Tang X, Liang L, Tang P, Pan Q, Zhu Q, Yang S, Chang Z, Guo Z, Wu G, and Tang S
Subjects: rr-tb, treatment outcomes, influencing factors, china, Infectious and parasitic diseases, RC109-216
Abstract: Liping Zou,1,&ast; Wanli Kang,2,&ast; Chunhui Guo,3,&ast; Juan Du,4,&ast; Qing Chen,1 Zhengyu Shi,1 Xianzhen Tang,1 Li Liang,1 Peijun Tang,5 Qing Pan,6 Qingdong Zhu,7 Song Yang,8 Zhanlin Chang,9 Zhouli Guo,1 Guihui Wu,1 Shenjie Tang2 1Department of Tuberculosis, Public Health Clinical Center of Chengdu, Chengdu, People’s Republic of China; 2Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, People’s Republic of China; 3Department of Tuberculosis, Harbin Chest Hospital, Harbin, People’s Republic of China; 4Department of Tuberculosis, Wuhan Pulmonary Hotel, Wuhan, People’s Republic of China; 5Department of Tuberculosis, the Fifth People’s Hospital of Suzhou, Suzhou, People’s Republic of China; 6Department of Respiratory and Critical Care Medicine, Anqing Municipal Hospital, Anqing, People’s Republic of China; 7Department of Tuberculosis, the Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China; 8General Internal Medicine Department, Chongqing Public Health Medical Center, Chongqing, People’s Republic of China; 9Department of Surgery, the Third People’s Hospital of Tibet Autonomous Region, Lasa, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Guihui Wu, Department of Tuberculosis, Public Health Clinical Center of Chengdu, Jingjusi 18 Street, Jingjiang District, Chengdu, Sichuan, People’s Republic of China, Tel +86-28-8455-0573, Email wghwgh2584@sina.com Shenjie Tang, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, 101149, People’s Republic of China, Tel +86-13621028338, Email tangsj1106@vip.sina.comObjective: Rifampin-resistant tuberculosis (RR-TB) remains a serious global public health concern. We assessed treatment outcomes and associated influencing factors among RR-TB patients in China.Methods: This research enrolled 1339 patients who started RR-TB treatment between May 2018 and April 2020 in China retrospectively. Data were collected from the electronic medical records. Multivariable logistic regression analysis was used to identify the influencing factors related to unfavorable outcomes.Results: Of the 1339 RR-TB patients, 78.8% (1055/1339) achieved treatment success (cured or treatment completed), 5.1% (68/1339) experienced treatment failure, 1.1% (15/1339) died during treatment, 10.1% (135/1339) were lost to follow-up, and 4.9% (66/1339) were not evaluated. About 67.7% (907/1339) of patients experienced at least one adverse event (AE). The most common AE was hypohepatia (507/1339, 37.9%), followed by hyperuricemia (429/1339, 32.0%), anemia (368/1339, 27.5%), electrolyte disturbance (318/1339, 23.7%), peripheral neuritis (245/1339, 18.3%), and gastrointestinal reactions (203/1339, 15.2%). Multivariate analysis showed that age ≥ 60 years [adjusted odds ratio (aOR): 1.96, 95% confidence interval (CI): 1.39– 2.77], national minority (aOR: 2.36, 95% CI: 1.42– 3.93), smoking (aOR: 1.50, 95% CI: 1.10– 2.04), cardiopathy (aOR: 2.90, 95% CI: 1.33– 6.31), tumors (aOR: 9.84, 95% CI: 2.27– 42.67), immunocompromise (aOR: 2.17, 95% CI: 1.21– 3.91), re-treated TB (aOR: 1.46, 95% CI: 1.08– 1.97), and experienced gastrointestinal reactions (aOR: 2.27, 95% CI: 1.52– 3.40) were associated with unfavorable outcomes. Body mass index (BMI) ≥ 18.5 kg/m2, regimens containing bedaquiline and experienced adverse events (AEs) such as hypohepatia, leukopenia, peripheral neuritis, and optic neuritis were associated with favorable outcomes.Conclusion: High rates of treatment success were achieved for RR-TB patients at tertiary tuberculosis hospitals in China. Age ≥ 60 years, national minority, smoking status, comorbidities, re-treated TB, and experienced gastrointestinal reactions were independent prognostic factors for unfavorable treatment outcomes.Keywords: RR-TB, treatment outcomes, influencing factors, China
Published: 2024

15. Research Progress on the Effect and Mechanism of Exercise Intervention on Sarcopenia Obesity

Author: Chen J, Jia S, Guo C, Fan Z, Yan W, and Dong K
Subjects: sarcopenic obesity，exercise，cytokines，microrna，mitochondrial quality control，inflammation, Geriatrics, RC952-954.6
Abstract: Jun Chen,1 Shaohui Jia,2 Chenggen Guo,3 Zhiwei Fan,1 Weiyi Yan,1 Kunwei Dong4 1School of Graduate, Wuhan Sport University, Wuhan, 430079, People’s Republic of China; 2School of Sports Medicine, Wuhan Sport University, Wuhan, 430079, People’s Republic of China; 3School of Sports Training, Wuhan Sport University, Wuhan, 430079, People’s Republic of China; 4School of Arts, Wuhan Sport University, Wuhan, 430079, People’s Republic of ChinaCorrespondence: Kunwei Dong, School of Arts, Wuhan Sport University, Wuhan, 430079, People’s Republic of China, Email 383239567@qq.comAbstract: With the increasingly severe situation of obesity and population aging, there is growing concern about sarcopenia obesity (SO). SO refers to the coexistence of obesity and sarcopenia, which imposes a heavier burden on individuals and society compared to obesity or sarcopenia alone. Therefore, comprehending the pathogenesis of SO and implementing effective clinical interventions are vital for its prevention and treatment. This review uses a comprehensive literature search and analysis of PubMed, Web of Science, and CNKI databases, with search terms including “Sarcopenic obesity”, “exercise”, “cytokines”, “inflammation”, “mitochondrial quality control”, and “microRNA”, covering relevant studies published up to July 2024. The results indicate that the pathogenesis of SO is complex, involving mechanisms like age-related changes in body composition, hormonal alterations, inflammation, mitochondrial dysfunction, and genetic and epigenetic factors. Regarding exercise interventions for SO, aerobic exercise can reduce fat mass, resistance exercise can increase skeletal muscle mass and strength, and combined exercise can achieve both, making it the optimal intervention for SO. The potential mechanisms by which exercise may prevent and treat SO include regulating cytokine secretion, inhibiting inflammatory pathways, improving mitochondrial quality, and mediating microRNA expression. This review emphasizes the effectiveness of exercise interventions in mitigating sarcopenic obesity through comprehensive analysis of its multifactorial pathogenesis and the mechanistic insights into exercise’s therapeutic effects. Understanding these mechanisms informs targeted therapeutic strategies aimed at alleviating the societal and individual burdens associated with SO.Keywords: sarcopenic obesity, exercise, cytokines, microRNA, mitochondrial quality control, inflammation
Published: 2024

16. Directionality of nuclear recoils in a liquid argon time projection chamber

Author: Collaboration, The DarkSide-20k, Agnes, P., Ahmad, I., Albergo, S., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Amaudruz, P., Corona, M. Atzori, Ave, M., Avetisov, I. Ch., Azzolini, O., Back, H. O., Balmforth, Z., Barrado-Olmedo, A., Barrillon, P., Basco, A., Batignani, G., Bocci, V., Bonivento, W. M., Bottino, B., Boulay, M. G., Busto, J., Cadeddu, M., Caminata, A., Canci, N., Cappello, G., Capra, A., Caprioli, S., Caravati, M., Cargioli, N., Carlini, M., Castello, P., Cataudella, V., Cavalcante, P., Cavuoti, S., Cebrian, S., Ruiz, J. M. Cela, Chashin, S., Chepurnov, A., Chyhyrynets, E., Cifarelli, L., Cintas, D., Citterio, M., Cleveland, B., Cocco, V., Vilda, E. Conde, Consiglio, L., Copello, S., Covone, G., Czubak, M., D'Aniello, M., D'Auria, S., Rolo, M. D. Da Rocha, Davini, S., de Candia, A., De Cecco, S., De Gruttola, D., De Filippis, G., Dell'Aquila, D., De Pasquale, S., De Rosa, G., Dellacasa, G., Derbin, A. V., Devoto, A., Di Capua, F., Di Noto, L., Dionisi, C., Di Stefano, P., Dolganov, G., Dordei, F., Elersich, A., Ellingwood, E., Erjavec, T., Diaz, M. Fernandez, Fiorillo, G., Franchini, P., Franco, D., Funicello, N., Gabriele, F., Gahan, D., Galbiati, C., Gallina, G., Gallus, G., Garbini, M., Abia, P. Garcia, Gendotti, A., Ghiano, C., Giganti, C., Giovanetti, G. K., Casanueva, V. Goicoechea, Gola, A., Grauso, G., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guan, M., Guerzoni, M., Gulino, M., Guo, C., Hackett, B. R., Hallin, A. L., Hamer, A., Haranczyk, M., Hessel, T., Hill, S., Horikawa, S., Hubaut, F., Hucker, J., Hugues, T., Ianni, An., Ippolito, V., Jillings, C., Jois, S., Kachru, P., Kemmerich, N., Kemp, A. A., Kendziora, C. L., Kimura, M., Kochanek, I., Kondo, K., Korga, G., Koulosousas, S., Kubankin, A., Kuss, M., Kuzniak, M., La Commara, M., Lai, M., Guirriec, E. Le, Leason, E., Leoni, A., Li, X., Lidey, L., Lissia, M., Luzzi, L., Lychagina, O., Macfadyen, O., Machulin, I. N., Manecki, S., Manthos, I., Mapelli, L., Margotti, A., Marik, S. M., Mariani, C., Maricic, J., Marini, A., Martínez, M., Martoff, C. J., Matteucci, G., Mavrokoridis, K., McDonald, A. B., Messina, A., Milincic, R., Mitra, A., Moharana, A., Monroe, J., Moretti, E., Morrocchi, M., Mróz, T., Muratova, V. N., Muscas, C., Musico, P., Nania, R., Nessi, M., Nieradka, G., Nikolopoulos, K., Nowak, J., Olchansky, K., Oleinik, A., Oleynikov, V., Organtini, P., de Solórzano, A. Ortiz, Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Paternoster, G., Pegoraro, P. A., Pelczar, K., Pesudo, V., Piacentini, S., Pino, N., Pocar, A., Poehlmann, D. M., Pordes, S., Pralavorio, P., Price, D., Ragusa, F., Ramachers, Y., Razeti, M., Renshaw, A. L., Rescigno, M., Retiere, F., Rignanese, L. P., Ripoli, C., Rivetti, A., Roberts, A., Roberts, C., Rode, J., Rogers, G., Romero, L., Rossi, M., Rubbia, A., Sabia, M. A., Salomone, P., Sandford, E., Sanfilippo, S., Santone, D., Santorelli, R., Savarese, C., Scapparone, E., Schillaci, G., Schuckman II, F. G., Scioli, G., Simeone, M., Skensved, P., Skorokhvatov, M. D., Smirnov, O., Smirnova, T., Smith, B., Sosa, A., Spadoni, F., Spangenberg, M., Stefanizzi, R., Steri, A., Stornelli, V., Stracka, S., Stringer, M., Sulis, S., Sung, A., Suvorov, Y., Szelc, A. M., Tartaglia, R., Taylor, A., Taylor, J., Tedesco, S., Testera, G., Thieme, K., Thorpe, T. N., Tonazzo, A., Tricomi, A., Unzhakov, E. V., John, T. Vallivilayil, Van Uffelen, M., Viant, T., Viel, S., Vogelaar, R. B., Vossebeld, J., Wada, M., Walczak, M. B., Wang, H., Wang, Y., Westerdale, S., Williams, L., Wingerter-Seez, I., Wojaczynski, R., Wojcik, Ma. M., Wright, T., Xie, Y., Yang, C., Zabihi, A., Zakhary, P., Zani, A., Zichichi, A., Zuzel, G., and Zykova, M. P.
Subjects: Physics - Instrumentation and Detectors
Abstract: The direct search for dark matter in the form of weakly interacting massive particles (WIMP) is performed by detecting nuclear recoils (NR) produced in a target material from the WIMP elastic scattering. A promising experimental strategy for direct dark matter search employs argon dual-phase time projection chambers (TPC). One of the advantages of the TPC is the capability to detect both the scintillation and charge signals produced by NRs. Furthermore, the existence of a drift electric field in the TPC breaks the rotational symmetry: the angle between the drift field and the momentum of the recoiling nucleus can potentially affect the charge recombination probability in liquid argon and then the relative balance between the two signal channels. This fact could make the detector sensitive to the directionality of the WIMP-induced signal, enabling unmistakable annual and daily modulation signatures for future searches aiming for discovery. The Recoil Directionality (ReD) experiment was designed to probe for such directional sensitivity. The TPC of ReD was irradiated with neutrons at the INFN Laboratori Nazionali del Sud, and data were taken with 72 keV NRs of known recoil directions. The direction-dependent liquid argon charge recombination model by Cataudella et al. was adopted and a likelihood statistical analysis was performed, which gave no indications of significant dependence of the detector response to the recoil direction. The aspect ratio R of the initial ionization cloud is estimated to be 1.037 +/- 0.027 and the upper limit is R < 1.072 with 90% confidence level, Comment: 20 pages, 10 figures, submitted to Eur. Phys. J. C
Published: 2023

17. Efficient Dynamic Analysis of Complex Beam Systems for Artillery Firing Using Time-Varying Mechanics

Author: Guo, C. Y., Yang, G. L., and Wang, Z. C.
Published: 2024
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18. Flavonoids and Gastric Cancer Therapy: From Signaling Pathway to Therapeutic Significance

Author: Cai J, Tan X, Hu Q, Pan H, Zhao M, Guo C, Zeng J, Ma X, and Zhao Y
Subjects: flavonoid, gastric cancer, apoptosis, angiogenesis, Therapeutics. Pharmacology, RM1-950
Abstract: Jiaying Cai,1,&ast; Xiyue Tan,2,&ast; Qichao Hu,2,&ast; Huafeng Pan,3 Maoyuan Zhao,4 Cui Guo,4 Jinhao Zeng,1,4,5 Xiao Ma,2 Yanling Zhao6 1School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 3Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 4TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 5Department of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 6Department of Pharmacy, Chinese PLA General Hospital, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jinhao Zeng; Yanling Zhao, Email zengjinhao@cdutcm.edu.cn; zhaoyl2855@126.comAbstract: Gastric cancer (GC) is a prevalent gastrointestinal tumor characterized by high mortality and recurrence rates. Current treatments often have limitations, prompting researchers to explore novel anti-tumor substances and develop new drugs. Flavonoids, natural compounds with diverse biological activities, are gaining increasing attention in this regard. We searched from PubMed, Web of Science, SpringerLink and other databases to find the relevant literature in the last two decades. Using “gastric cancer”, “stomach cancers”, “flavonoid”, “bioflavonoid”, “ 2-Phenyl-Chromene” as keywords, were searched, then analyzed and summarized the mechanism of flavonoids in the treatment of GC. It was revealed that the anti-tumor mechanism of flavonoids involves inhibiting tumor growth, proliferation, invasion, and metastasis, as well as inducing cell death through various processes such as apoptosis, autophagy, ferroptosis, and pyroptosis. Additionally, combining flavonoids with other chemotherapeutic agents like 5-FU and platinum compounds can potentially reduce chemoresistance. Flavonoids have also demonstrated enhanced biological activity when used in combination with other natural products. Consequently, this review proposes innovative perspectives for the development of flavonoids as new anti-GC agents.Keywords: flavonoid, gastric cancer, apoptosis, angiogenesis
Published: 2024

19. Risk Factors and Prognosis of Perioperative Atrial Fibrillation in Elderly Patients Undergoing VATS Lung Surgery: A Retrospective Cohort Study

Author: Han Y, Guo C, Zhu Q, Liu Z, Zhang Y, Li S, and Shen L
Subjects: video-assisted thoracoscopic surgery, aged, atrial fibrillation, risk factor, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Yue Han,1,&ast; Chao Guo,2,&ast; Qianmei Zhu,1 Zijia Liu,1 Yuelun Zhang,3 Shanqing Li,2 Le Shen1 1Department of Anesthesiology, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, People’s Republic of China; 2Department of Thoracic Surgery, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, People’s Republic of China; 3Department of Medical Research Center, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zijia Liu, Department of Anesthesiology, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, 100730, People’s Republic of China, Tel/Fax +861069155580, Email liu-zj02@126.comBackground: Atrial fibrillation (AF) has become the most common postoperative arrhythmia of thoracic surgery. This study aimed to investigate the risk factors and complications of perioperative atrial fibrillation (PoAF) in elderly patients who underwent video-assisted thoracoscopic surgery (VATS).Methods: Data were collected from patients who underwent VATS between January 2013 and December 2022 at Peking Union Medical College Hospital (PUMCH). Univariable analyses and multivariable logistic regression analyses were used to determine the factors correlated with PoAF. Receiver operating characteristic (ROC) curve was used to evaluate the discrimination of the indicators to predict PoAF.Results: The study enrolled 2920 patients, with a PoAF incidence of 5.2% (95% CI 4.4%-6.0%). In the logistic regression analyses, male sex (OR=1.496, 95% CI 1.056– 2.129, P=0.024), left atrial anteroposterior dimension (LAD) ≥ 40 mm (OR=2.154, 95% CI 1.235– 3.578, P=0.004), hypertension (HTN) without regular treatment (OR=2.044, 95% CI 0.961– 3.921, P=0.044), a history of hyperthyroidism (OR=4.443, 95% CI 0.947– 15.306, P=0.030), surgery of the left upper lobe (compared to other lung lobes) (OR=1.625, 95% CI 1.139– 2.297, P=0.007), postoperative high blood glucose (BG) (OR=2.482, 95% CI 0.912– 5.688, P=0.048), and the time of chest tube removal (per day postoperatively) (OR=1.116, 95% CI 1.038– 1.195, P=0.002) were found to be significantly associated with PoAF. The area under the ROC curve was 0.707 (95% CI 0.519– 0.799). 86.9% patients were successfully converted to sinus rhythm. Compared with the non-PoAF group, the PoAF group had significantly greater risks of prolonged air leakage, postoperative acute coronary syndrome, longer ICU stays, and longer hospital stays.Conclusion: Male sex, LAD≥ 40 mm, HTN without regular treatment, a history of hyperthyroidism, surgery of the left upper lobe, postoperative BG, and the time of chest tube removal were associated with PoAF. These findings may help clinicians identify high-risk patients and take preventive measures to minimize the incidence and adverse prognosis of PoAF.Keywords: video-assisted thoracoscopic surgery, aged, atrial fibrillation, risk factor
Published: 2024

20. Pharmacokinetics and Bioequivalence of Apremilast Tablets in Chinese Healthy Subjects Under Fasting and Postprandial States

Author: Bai W, Sun X, Qiu B, Guo C, Song H, Hu Y, Zhang X, Yin P, Wang X, and Dong Z
Subjects: apremilast, psoriasis, pharmacokinetics, bioequivalence, safety., Therapeutics. Pharmacology, RM1-950
Abstract: Wanjun Bai,1 Xue Sun,1 Bo Qiu,1 Caihui Guo,1 Haojing Song,1 Yiting Hu,1 Xueyuan Zhang,2 Peihua Yin,3 Xiaoru Wang,3 Zhanjun Dong1 1Department of Pharmacy, Hebei General Hospital, Hebei Key Laboratory of Clinical Pharmacy, Shijiazhuang, Hebei, People’s Republic of China; 2Center for Clinical Pharmacology, Shanghai Innovstone Therapeutics Limited, Shanghai, People’s Republic of China; 3Center for Clinical Pharmacology, CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd, Shijiazhuang, People’s Republic of ChinaCorrespondence: Zhanjun Dong, Department of Pharmacy, Hebei General Hospital, Hebei Key Laboratory of Clinical Pharmacy, No. 348 Heping West Road, Xinhua District, Shijiazhuang City, Hebei Province, 050051, People’s Republic of China, Tel +86 311 85988604, Email 13313213656@126.comObjective: This study compared the pharmacokinetics, safety and bioequivalence (BE) of generic and original apremilast tablets in healthy Chinese subjects under fasting and postprandial conditions, providing sufficient evidence for abbreviated new drug application.Methods: A randomized, open-label, two-formulation, single-dose, two-period crossover pharmacokinetic study was performed. Thirty-two eligible healthy Chinese subjects were enrolled in fasting and postprandial studies, respectively. In each trial, subjects received a single 30-mg dose of the test or reference apremilast tablet, followed by a 7-day washout interval between periods. Serial blood samples were obtained for up to 48 h post-intake in each period, and the plasma concentrations of apremilast were determined by a validated method. The primary pharmacokinetic (PK) parameters, including the maximum plasma concentration (Cmax), the areas under the plasma concentration–time curve (AUC0-t, AUC0-∞), were calculated using the non-compartmental method. The geometric mean ratios of the two formulations and the corresponding 90% confidence intervals (CIs) were acquired for bioequivalence analysis. The safety of both formulations was also evaluated.Results: Under fasting and postprandial states, the PK parameters of the test drug were similar to those of the reference drug. The 90% CIs of the geometric mean ratios of the test to reference formulations were 94.09– 103.44% for Cmax, 94.05– 103.51% for AUC0-t, and 94.56– 103.86% for AUC0-∞ under fasting conditions, and 99.18– 112.48% for Cmax, 98.79– 106.02% for AUC0-t, and 98.95– 105.89% for AUC0-∞ under postprandial conditions, all of which were within the bioequivalence range of 80.00– 125.00%. Both formulations were well tolerated, and no serious adverse events occurred during the study.Conclusion: The trial confirmed that the PK parameters of the generic and original apremilast tablets were bioequivalent in healthy Chinese subjects under fasting and postprandial states, which met the predetermined regulatory standards. Both formulations were safe and well tolerated.Clinical Trial Registration: chinaDrugtrials.org.cn, identifier CTR20191056 (July 30, 2019); chictr.org.cn, identifier ChiCTR2300076806 (October 19, 2023).Keywords: apremilast, psoriasis, pharmacokinetics, bioequivalence, safety
Published: 2024

21. MALAT1 Knockdown Inhibits the Proliferation, Migration, and Collagen Deposition of Human Hypertrophic Scar Fibroblasts via Targeting miR-29a-3p/Smurf2 Axis

Author: Guo C, Liu X, Qiu K, Tu L, and Liu D
Subjects: hypertrophic scar, fibroblasts, malat1, mir-29a-3p, smurf2, tgf-β signaling pathway, Dermatology, RL1-803
Abstract: Chunyan Guo,1,2,&ast; Xiaoxiao Liu,1,&ast; Keqing Qiu,2 Longxiang Tu,1 Dewu Liu1 1Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 2Department of Dermatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Dewu Liu, Email ndyfy00706@ncu.edu.cnPurpose: Hypertrophic scarring (HS) is commonly described as an abnormal post-traumatic tissue repair characterized by excessive hypercellularity and extracellular matrix (ECM) deposition. Mounting evidence suggests that MALAT1 is maladjusted in many fibrotic diseases, but its contribution to HS progression remains poorly understood. Hence, we sought to elucidate the fundamental role of MALAT1 in HS.Methods: The expression of MALAT1, miR-29a-3p, and Smurf2 in skin tissues and fibroblasts was assessed by RT-qPCR and Western blotting. Furthermore, lentiviruses, RNAi, or plasmids were utilized to transfect hypertrophic scar fibroblasts (HSFs) for gene overexpression or downregulation. The biological behaviors of HSFs were quantified by the CCK-8 assay, wound healing assay, transwell assay, and flow cytometry. Mechanistically, bioinformatics analysis, dual-luciferase reporter assays, and rescue experiments were performed to verify the relationship between miR-29a-3p and MALAT1 or Smurf2.Results: Our data indicate that MALAT1, Smurf2 were overexpressed while miR-29a-3p was suppressed in HS tissues and fibroblasts. Downregulation of MALAT1 may lead to decreased proliferation, migration, and invasion of fibroblasts, accompanied by enhanced apoptosis, reduced TGF-β signal transduction, and ECM accumulation in HSFs, by enhancing miR-29a-3p and suppressing Smurf2 expression. Mechanistically, MALAT1 acted as a sponge for miR-29a-3p, while miR-29a-3p directly targeted Smurf2. More importantly, rescue experiments suggested that MALAT1 downregulation induced impact on the proliferation, migration, and invasion of HSFs could be partially overturned through miR-29a-3p knockdown or Smurf2 overexpression.Conclusion: MALAT1 knockdown inhibits the proliferation, migration, invasion, and collagen deposition of HSFs via targeting the miR-29a-3p/Smurf2 axis, which may reveal a promising therapeutic exploitable vulnerability to HS. Keywords: hypertrophic scar, fibroblasts, MALAT1, miR-29a-3p, Smurf2, TGF-β signaling pathway
Published: 2024

22. The Suitable Population for Opportunistic Low Bone Mineral Density Screening Using Computed Tomography

Author: Zhang J, Luo X, Zhou R, Guo C, Xu K, Qu G, Zou L, Yao W, Lin S, and Zhang Z
Subjects: bone mineral density, chest computed tomography, dual-energy x-ray absorptiometry, attenuation value, Geriatrics, RC952-954.6
Abstract: Jiongfeng Zhang,1,&ast; Xiaohui Luo,1,&ast; Ruiling Zhou,2,&ast; Chong Guo,1 Kai Xu,1 Gaoyang Qu,1 Le Zou,1 Wenye Yao,1 Shifan Lin,1 Zhiping Zhang1 1Department of Orthopedics, the 3rd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330008, People’s Republic of China; 2Department of Dermatology, Jiangxi Provincial Dermatology Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330008, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Shifan Lin, Email 66031226@qq.com; Zhiping Zhang, Tel +86 791-88862249, Email ndsfy001425@ncu.edu.cnObjective: To explore the suitable population of CT value for predicting low bone mineral density (low-BMD).Methods: A total of 1268 patients who underwent chest CT examination and DXA within one-month period retrospectively analyzed. The CT attenuation values of trabecular bone were measured in mid-sagittal plane from thoracic vertebra 7 (T7). Receiver operating characteristic (ROC) curves were used to evaluate the ability to diagnose low-BMD.Results: The AUC for diagnosing low BMD was larger in women than in men (0.894 vs 0.744, p < 0.05). The AUC increased gradually with the increase of age but decreased gradually with the increase in height and weight (p < 0.05). In females, when specificity was adjusted to approximately 90%, a threshold of 140.25 HU has a sensitivity of 69.3%, which is higher than the sensitivity of 36.5% in males for distinguishing low-BMD from normal. At the age of 70 or more, when specificity was adjusted to approximately 90%, a threshold of 126.31 HU has a sensitivity of 76.1%, which was higher than that of other age groups.Conclusion: For patients who had completed chest CTs, the CT values were more effective in predicting low-BMD in female, elderly, lower height, and lower weight patients.Keywords: bone mineral density, chest computed tomography, dual-energy X-ray absorptiometry, attenuation value
Published: 2024

23. Chromatic aberrations correction of attosecond high-order harmonic beams by flat-top spatial shaping of the fundamental beam

Author: Veyrinas, K., Plach, M., Peschel, J., Hoflund, M., Catoire, F., Valentin, C., Smorenburg, P., Dacasa, H., Maclot, S., Guo, C., Wikmark, H., Zair, A., Strelkov, V., Picot, C., Arnold, C., Eng-Johnsson, P., Huillier, A. L, Mevel, E., and Constant, E.
Subjects: Physics - Optics
Abstract: Attosecond pulses created by high-order harmonic generation in gases often exhibit strong chromatic aberrations, arising from the broad bandwidth and wavelength-dependent nonlinear light-matter interaction. When the driving laser intensity varies spatially, as for Gaussian driving beams, the apparent source position of the harmonics differs significantly from one order to the next, thus affecting the achievable intensity and duration of the attosecond pulses when they are focused on a target. We show that these chromatic aberrations can be reduced by spatially shaping the fundamental beam to generate high-order harmonics with a driver having a flat-top profile inside the gas medium. By measuring both the intensity profile and wavefront for each harmonic in a plane, we access the extreme ultra-violet (XUV) beam properties and investigate these properties near focus. We observe that controlling chromatic aberrations by flat-top spatial shaping strongly reduces the variation of the XUV spectrum on the beam axis during propagation and, in return, the longitudinal sensitivity of both the temporal profiles and the temporal shifts of the focused attosecond pulses., Comment: 12 pages, 8 figures + supplementary material: 10 pages, 13 figures
Published: 2023
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24. Research of radon diffusion behavior in liquid scintillator

Author: Xu, Z. F., Guo, C., Liu, J. C., Zhang, Y. P., Zhang, P., Yang, C. G., Tang, Q., Liu, Y., Li, C., and Guan, T. Y.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The background caused by radon and its daughters is an important background in the low background liquid scintillator (LS) detectors. The study of the diffusion behaviour of radon in the LS contributes to the analysis of the related background caused by radon. Methodologies and devices for measuring the diffusion coefficient and solubility of radon in materials are developed and described. The radon diffusion coefficient of the LS was measured for the first time and in addition the solubility coefficient was also obtained. In addition, the radon diffusion coefficient of the polyolefine film which is consistent with data in the literature was measured to verify the reliability of the diffusion device., Comment: 9 pages, 7 figures
Published: 2023
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25. System upgrade for $\mu$Bq/m$^3$ level $^{222}$Rn concentration measurement

Author: Liu, Y., Zhang, Y. P., Liu, J. C., Guo, C., Zhang, C. G. Yang. P., Tang, Q., Xu, Z. F., Li, C., Guan, T. Y., and Wang, S. B.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The Jiangmen Underground Neutrino Observatory (JUNO), a 20 kton multipurpose underground liquid scintillator detector, was proposed for the determination of the neutrino mass hierarchy as primary physics goal. The central detector will be submerged in a water Cherenkov detector to lower the background from the environment and cosmic muons. Radon is one of the primary background sources. Nitrogen will be used in several sub-systems, and a highly sensitive radon detector has to be developed to measure its radon concentration. A system has been developed based on $^{222}$Rn enrichment of activated carbon and $^{222}$Rn detection based on the electrostatic collection. This paper presents the detail of a $\mu$Bq/m$^3$ level $^{222}$Rn concentration measurement system and gives detailed information about how the adsorption coefficient was measured and how the temperature, flow rate, and $^{222}$Rn concentration affect the adsorption coefficient., Comment: 18 pages, 9 figures
Published: 2023

26. Developing a single phase liquid argon detector with SiPM readout

Author: Wang, L., Lei, Y., Wang, T. A., Guo, C., Zhao, K. K., Liang, X. H., Wang, S. B., and Chen, Y. D.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: Liquid argon is used as a target material in several current and planned experiments related to dark matter direct searching and neutrino detection. SiPM is becoming the standard for scintillator detectors because of its advantages over traditional PMT. In this paper, we developed a single-phase liquid argon detector using eight 1 $\times$1 inch$^2$ Hamamatsu S14161-6050HS 4$\times$4 SiPM arrays. The directly measured light yield is 25.7 $\pm$ 1.6 photo-electrons per keV, which corresponds to 12.8 $\pm$ 0.8 photo-electrons primarily generated by the argon scintillation. The rest is contributed by the cross-talk and after-pulse of SiPM. In addition, we provide an experimental method to estimate the effect of crosstalk and afterpulse on light yield using dark noise data. Finally, we quantitatively give the relationship between the light yield and the decay time of the slow component of a liquid argon detector., Comment: 15 pages, 13 figures
Published: 2022

27. Reactor neutrino physics potentials of cryogenic pure-CsI crystal

Author: Wang, L., Li, G. d., Yu, Z. Y., Liang, X. H., Wang, T. A., Liu, F., Sun, X. L., Guo, C., Zhang, X., Yu, L., and Chen, Y. D.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: This paper presents a world-leading scintillation light yield among inorganic crystals measured from a 0.5~kg pure-CsI detector operated at 77 Kelvin. Scintillation photons were detected by two 2-inch Hamamatsu SiPM arrays equipped with cryogenic front-end electronics. Benefiting the light yield enhancement of pure-CsI at low temperatures and the high photon detection efficiency of SiPM, a light yield of 30.1 photoelectrons per keV energy deposit was obtained for X-rays and $\gamma$-rays with energies from 5.9~keV to 59.6~keV. Instrumental and physical effects in the light yield measurement are carefully analyzed. This is the first stable cryogenic operation of kg-scale pure-CsI crystal readout by SiPM arrays at liquid nitrogen temperatures for several days. The world-leading light yield opens a door for the usage of pure-CsI crystal in several fields, particularly in detecting the coherent elastic neutrino-nucleus scattering of reactor neutrinos. The potential of using pure-CsI crystals in neutrino physics is discussed in the paper., Comment: 10 pages, 16 figures
Published: 2022

28. Optimizing Trigger-Level Track Reconstruction for Sensitivity to Exotic Signatures

Author: Di Petrillo, K. F., Farr, J. N., Guo, C., Holmes, T. R., Nelson, J., and Pachal, K.
Subjects: High Energy Physics - Experiment
Abstract: Many compelling beyond the Standard Model scenarios predict signals that result in unconventional charged particle trajectories. Signatures for which unusual tracks are the most conspicuous feature of the event pose significant challenges for experiments at the Large Hadron Collider (LHC), particularly for the trigger. This article presents a study of track-based triggers for a representative set of long-lived and unconventional signatures at the upcoming High Luminosity LHC, as well as resulting recommendations for the target parameters of a hardware-based tracking system. Scenarios studied include large multiplicities of low momentum tracks produced in a soft-unclustered-energy-pattern model, displaced leptons and anomalous prompt tracks predicted in a Supersymmetry model with long-lived staus, and displaced hadrons predicted in a Higgs portal scenario with long-lived scalars., Comment: arXiv admin note: substantial text overlap with arXiv:2203.07314
Published: 2022
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29. Characterization of two SiPM arrays from Hamamatsu and Onsemi for liquid argon detector

Author: Wang, T. A., Guo, C., Liang, X. H., Wang, L., Guan, M. Y., Yang, C. G., Liu, J. C., and Lin, F. Y.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Silicon photomultiplier (SiPM), a new type of photosensor, is considered a substitute for traditional photomultiplier tube (PMT) in the next generation of dark matter and neutrino detectors, especially in noble gas detectors like liquid argon. However, the design of compact SiPM arrays and their cryogenic electronics that can work in liquid argon is barely developed. Thus, two candidate SiPM arrays from Hamamatsu and Onsemi were selected to verify the feasibility and effectiveness of the design. In this work, we successfully developed a cryogenic electronics read-out system that connects and works with 1-inch 4$\times$4 SiPM arrays at 87~K. The power dissipation of amplifiers is less than 10 $\mu$W/mm$^2$. Furthermore, multiply significant characteristics of both types of SiPM arrays were measured at liquid argon temperature, such as dark count rate (DCR), breakdown voltage (V${_{bd}}$), single photoelectron (SPE) performance, signal to noise ratio (SNR) and correlated signal probability., Comment: 18 pages, 16 figures
Published: 2022
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30. Report of the Topical Group on Physics Beyond the Standard Model at Energy Frontier for Snowmass 2021

Author: Bose, Tulika, Boveia, Antonio, Doglioni, Caterina, Griso, Simone Pagan, Hirschauer, James, Lipeles, Elliot, Liu, Zhen, Shah, Nausheen R., Wang, Lian-Tao, Agashe, Kaustubh, Alimena, Juliette, Baum, Sebastian, Berkat, Mohamed, Black, Kevin, Gardner, Gwen, Gherghetta, Tony, Greaves, Josh, Haehn, Maxx, Harris, Phil C., Harris, Robert, Hogan, Julie, Jayawardana, Suneth, Kahn, Abraham, Kalinowski, Jan, Knapen, Simon, Lewis, Ian M., Narain, Meenakshi, Pachal, Katherine, Reece, Matthew, Reina, Laura, Robens, Tania, Tricoli, Alessandro, Wagner, Carlos E. M., Xu, Riley, Yu, Felix, Zarnecki, Filip, Aboubrahim, Amin, Albert, Andreas, Albrow, Michael, Altmannshofer, Wolfgang, Andonian, Gerard, Apresyan, Artur, Assamagan, Kétévi Adikle, Azzi, Patrizia, Baer, Howard, Baker, Michael J., Banerjee, Avik, Barger, Vernon, Batell, Brian, Bauer, Martin, Beauchesne, Hugues, Bein, Samuel, Belyaev, Alexander, Beniwal, Ankit, Berggren, Mikael, Bhattiprolu, Prudhvi N., Blinov, Nikita, Blondel, Alain, Brandt, Oleg, Cacciapaglia, Giacomo, Capdevilla, Rodolfo, Carena, Marcela, Cazzaniga, Cesare, Celiberto, Francesco Giovanni, Cesarotti, Cari, Chekanov, Sergei V., Cheng, Hsin-Chia, Chen, Thomas Y., Chen, Yuze, Chivukula, R. Sekhar, Citron, Matthew, Cline, James, Cohen, Tim, Collins, Jack H., Corrigan, Eric, Craig, Nathaniel, Craik, Daniel, Crivellin, Andreas, Curtin, David, Darmora, Smita, Das, Arindam, Dasu, Sridhara, de Cosa, Annapaola, Deandrea, Aldo, Delgado, Antonio, Demiragli, Zeynep, d'Enterria, David, Deppisch, Frank F., Dermisek, Radovan, Desai, Nishita, Deshpande, Abhay, de Vries, Jordy, Dickinson, Jennet, Dienes, Keith R., Di Petrillo, Karri Folan, Dolan, Matthew J., Dong, Peter, Draper, Patrick, Drewes, Marco, Dreyer, Etienne, Du, Peizhi, Eble, Florian, Ekhterachian, Majid, Endo, Motoi, Essig, Rouven, Farr, Jesse N., Fassi, Farida, Feng, Jonathan L., Ferretti, Gabriele, Filipetto, Daniele, Flacke, Thomas, Franceschini, Roberto, Franzosi, Diogo Buarque, Fujii, Keisuke, Fuks, Benjamin, Gadam, Sri Aditya, Gao, Boyu, Garcia-Bellido, Aran, Garcia, Isabel Garcia, Garzelli, Maria Vittoria, Gedney, Stephen, Genest, Marie-Hélène, Ghosh, Tathagata, Golkowski, Mark, di Cortona, Giovanni Grilli, Guler, Emine Gurpinar, Guler, Yalcin, Guo, C., Graf, Nate, Haisch, Ulrich, Hajer, Jan, Hamaguchi, Koichi, Han, Tao, Harris, Philip, Heinemeyer, Sven, Hill, Christopher S., Hiltbrand, Joshua, Holmes, Tova Ray, Homiller, Samuel, Hong, Sungwoo, Hopkins, Walter, Hsu, Shih-Chieh, Ilten, Phil, Islam, Wasikul, Iwamoto, Sho, Jeans, Daniel, Jeanty, Laura, Jia, Haoyi, Jindariani, Sergo, Johnson, Daniel, Kahlhoefer, Felix, Kahn, Yonatan, Karchin, Paul, Katsouleas, Thomas, Kawada, Shin-ichi, Kawamura, Junichiro, Kelso, Chris, Khoda, Elham E, Khoze, Valery, Kim, Doojin, Kitahara, Teppei, Klaric, Juraj, Klasen, Michael, Kong, Kyoungchul, Kotlarski, Wojciech, Kotwal, Ashutosh V., Kozaczuk, Jonathan, Kriske, Richard, Kulkarni, Suchita, Kumar, Jason, Kunkel, Manuel, Landsberg, Greg, Lane, Kenneth, Lange, Clemens, Lee, Lawrence, Liao, Jiajun, Lillard, Benjamin, Li, Lingfeng, Li, Shuailong, Li, Shu, List, Jenny, Li, Tong, Liu, Hongkai, Liu, Jia, Long, Jonathan D, Lunghi, Enrico, Lyu, Kun-Feng, Marfatia, Danny, Martinez, Dakotah, Martin, Stephen P., McGinnis, Navin, McGinty, Karrick, Mękała, Krzysztof, Meloni, Federico, Mikulenko, Oleksii, Huang, Ming, Mishra, Rashmish K., Mitra, Manimala, Mitsou, Vasiliki A., Moon, Chang-Seong, Moreno, Alexander, Moroi, Takeo, Mourou, Gerard, Mrowietz, Malte, Muggli, Patric, Nakajima, Jurina, Nath, Pran, Nelson, J., Neubert, Matthias, Nosler, Laura, de Vera, Maria Teresa Núñez Pardo, Okada, Nobuchika, Okada, Satomi, Okorokov, Vitalii A., Onel, Yasar, Ou, Tong, Ovchynnikov, Maksym, Padhan, Rojalin, Pani, Priscilla, Panizzi, Luca, Papaefstathiou, Andreas, Pedro, Kevin, Peña, Cristián, Piazza, Federica, Pinfold, James, Pinna, Deborah, Porod, Werner, Potter, Chris, Prim, Markus Tobias, Profumo, Stefano, Proudfoot, James, Rai, Mudit, Rajec, Filip, Ramos, Reese, Ramsey-Musolf, Michael J., Resta-Lopez, Javier, Reuter, Jürgen, Ringwald, Andreas, Rizzi, Chiara, Rizzo, Thomas G., Rossi, Giancarlo, Ruiz, Richard, Rygaard, L., Sahai, Aakash A., Salam, Shadman, Sandick, Pearl, Sathyan, Deepak, Scherb, Christiane, Schwaller, Pedro, Schwarze, Leonard, Scott, Pat, Sekmen, Sezen, Sengupta, Dibyashree, Sen, S., Sfyrla, Anna, Shackelford, Eric, Sharma, T., Sharma, Varun, Shelton, Jessie, Shepherd, William, Shin, Seodong, Simmons, Elizabeth H., Sloneker, Zoie, Sierra, Carlos Vázquez, Sjöstrand, Torbjörn, Snyder, Scott, Song, Huayang, Stark, Giordon, Stengel, Patrick, Stohr, Joachim, Stolarski, Daniel, Strassler, Matt, Strobbe, Nadja, Gonski, Julia, Suarez, Rebeca Gonzalez, Suehara, Taikan, Su, Shufang, Su, Wei, Syed, Raza M., Tait, Tim M. P., Tajima, Toshiki, Tang, Andy, Tata, Xerxes, Tchalokov, Teodor, Thamm, Andrea, Thomas, Brooks, Toro, Natalia, Tran, Nhan V., Truong, Loan, Tsai, Yu-Dai, Tuecke, Eva, Venkatasubramanian, Nikhilesh, Verhaaren, Chris B., Vuosalo, Carl, Wang, Xiao-Ping, Wang, Xing, Wang, Yikun, Wang, Zhen, Weber, Christian, White, Glen, White, Martin, Williams, Anthony G., Williams, Brady, Williams, Mike, Willocq, Stephane, Woodcock, Alex, Wu, Yongcheng, Xie, Ke-Pan, Xie, Keping, Xie, Si, Yeh, C. -H., Yonamine, Ryo, Yu, David, Yu, S. -S., Zaazoua, Mohamed, Żarnecki, Aleksander Filip, Zembaczynski, Kamil, Zhang, Danyi, Zhang, Jinlong, Zimmermann, Frank, and Zurita, Jose
Subjects: High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract: This is the Snowmass2021 Energy Frontier (EF) Beyond the Standard Model (BSM) report. It combines the EF topical group reports of EF08 (Model-specific explorations), EF09 (More general explorations), and EF10 (Dark Matter at Colliders). The report includes a general introduction to BSM motivations and the comparative prospects for proposed future experiments for a broad range of potential BSM models and signatures, including compositeness, SUSY, leptoquarks, more general new bosons and fermions, long-lived particles, dark matter, charged-lepton flavor violation, and anomaly detection., Comment: 108 pages + 38 pages references and appendix, 37 figures, Report of the Topical Group on Beyond the Standard Model Physics at Energy Frontier for Snowmass 2021. The first nine authors are the Conveners, with Contributions from the other authors
Published: 2022

31. Sensitivity projections for a dual-phase argon TPC optimized for light dark matter searches through the ionization channel

Author: Agnes, P., Ahmad, I., Albergo, S., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Amaudruz, P., Corona, M. Atzori, Auty, D. J., Ave, M., Avetisov, I. Ch., Avetisov, R. I., Azzolini, O., Back, H. O., Balmforth, Z., Barbarian, V., Olmedo, A. Barrado, Barrillon, P., Basco, A., Batignani, G., Berzin, E., Bondar, A., Bonivento, W. M., Borisova, E., Bottino, B., Boulay, M. G., Buccino, G., Bussino, S., Busto, J., Buzulutskov, A., Cadeddu, M., Cadoni, M., Caminata, A., Canci, N., Capra, A., Caprioli, S., Caravati, M., Cárdenas-Montes, M., Cargioli, N., Carlini, M., Castello, P., Cataudella, V., Cavalcante, P., Cavuoti, S., Cebrian, S., Ruiz, J. M. Cela, Chashin, S., Chepurnov, A., Chyhyrynets, E, Cicalò, C., Cifarelli, L., Cintas, D., Cocco, V., Vilda, E. Conde, Consiglio, L., Copello, S., Covone, G., Cross, S., Czudak, P., D'Aniello, M., D'Auria, S., Rolo, M. D. Da Rocha, Dadoun, O., Daniel, M., Davini, S., De Candia, A., De Cecco, S., De Falco, A., De Filippis, G., De Gruttola, D., De Pasquale, S., De Rosa, G., Dellacasa, G., Derbin, A. V., Devoto, A., Di Capua, F., Di Noto, L., Di Stefano, P., Dionisi, C., Dolganov, G., Dordei, F., Doria, L., Erjavec, T., Diaz, M. Fernandez, Fiorillo, G., Franceschi, A., Franchini, P., Franco, D., Frolov, E., Funicello, N., Gabriele, F., Gahan, D., Galbiati, C., Gallina, G., Gallus, G., Garbini, M., Abia, P. Garcia, Gendotti, A., Ghiano, C., Giampaolo, R. A., Giganti, C., Giorgi, M. A., Giovanetti, G. K., Casanueva, V. Goicoechea, Gola, A., Gorman, D., Diaz, R. Graciani, Grauso, G., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guan, M., Guerzoni, M., Gulino, M., Guo, C., Hackett, B. R., Hall, J. B., Hallin, A. L., Hamer, A., Helton, H., Haranczyk, M., Hessel, T., Hill, S., Horikawa, S., Hubaut, F., Hugues, T., Hungerford, E. V., Ianni, An., Ippolito, V., Jillings, C., Kachru, P., Kemp, A. A., Kendziora, C. L., Keppel, G., Khomyakov, A. V., Kimura, M., Kochanek, I., Kondo, K., Korga, G., Koulosousas, S., Kubankin, A., Kuss, M., Kuźniak, M., La Commara, M., Lai, M., Guirriec, E. Le, Leason, E., Li, X., Lidey, L., Lipp, J., Lissia, M., Longo, G., Luzzi, L., Macfadyen, O., Machulin, I. N., Manthos, I., Mapelli, L., Margotti, A., Mari, S. M., Mariani, C., Maricic, J., Marini, A., Martínez, M., Martoff, C. J., Masoni, A., Mavrokoridis, K., Mazzi, A., McDonald, A. B., Messina, A., Milincic, R., Moggi, A., Moharana, A., Monroe, J., Morrocchi, M., Mozhevitina, E. N., Mróz, T., Muratova, V. N., Muscas, C., Musico, P., Nania, R., Napolitano, T., Nessi, M., Nieradka, G., Nikolopoulos, K., Nikulin, I., Nowak, J., Olchansky, K., Oleinik, A., Oleynikov, V., Organtini, P., de Solórzano, A. Ortiz, Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Paternoster, G., Pegoraro, P. A., Pelczar, K., Pellegrino, C., Perotti, F., Pesudo, V., Piacentini, S., Pietropaolo, F., Pino, N., Pira, C., Pocar, A., Poehlmann, D. M., Pordes, S., Pralavorio, P., Price, D., Raffaelli, F., Ragusa, F., Ramachers, Y., Ramirez, A., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Resnati, F., Retiere, F., Rignanese, L. P., Ripoli, C., Rivetti, A., Roberts, A., Roberts, C., Rode, J., Rogers, G., Romero, L., Rossi, M., Rubbia, A., Sadashivajois, S., Saffold, T. R., Samoylov, O., Sandford, E., Sanfilippo, S., Santone, D., Santorelli, R., Savarese, C., Scapparone, E., Scioli, G., Semenov, D. A., Shchagin, A., Sheshukov, A., Simeone, M., Skensved, P., Skorokhvatov, M. D., Smirnov, O., Smirnova, T., Smith, B., Sokolov, A., Spangenberg, M., Stefanizzi, R., Steri, A., Stracka, S., Strickland, V., Stringer, M., Sulis, S., Sung, A., Suvorov, Y., Szelc, A. M., Türkoğ, C., Tartaglia, R., Taylor, A., Taylor, J., Tedesco, S., Testera, G., Thieme, K., Thorpe, T. N., Tonazzo, A., Torres-Lara, S., Tricomi, A., Unzhakov, E. V., John, T. Vallivilayil, Van Uffelen, M., Viant, T., Viel, S., Vishneva, A., Vogelaar, R. B., Vossebeld, J., Wada, M., Walczak, M. B., Wang, Y., Westerdale, S., Wheadon, R. J., Williams, L., Wingerter-Seez, I., Wojaczyński, R., Wojcik, Ma. M., Wojcik, Ma., Wright, T., Xie, Y., Yang, C., Zabihi, A., Zakhary, P., Zani, A., Zichichi, A., Zuzel, G., and Zykova, M. P.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Dark matter lighter than 10 GeV/c$^2$ encompasses a promising range of candidates. A conceptual design for a new detector, DarkSide-LowMass, is presented, based on the DarkSide-50 detector and progress toward DarkSide-20k, optimized for a low-threshold electron-counting measurement. Sensitivity to light dark matter is explored for various potential energy thresholds and background rates. These studies show that DarkSide-LowMass can achieve sensitivity to light dark matter down to the solar neutrino floor for GeV-scale masses and significant sensitivity down to 10 MeV/c$^2$ considering the Migdal effect or interactions with electrons. Requirements for optimizing the detector's sensitivity are explored, as are potential sensitivity gains from modeling and mitigating spurious electron backgrounds that may dominate the signal at the lowest energies.
Published: 2022
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32. Investigating the Effect of Various Fibers on Plasticity and Compressive Strength of Concrete Samples

Author: Sun, L., Fu, J., Wang, D., Haeri, H., Guo, C. L., and Cheng, H.
Published: 2024
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33. Navigating pediatric inguinal hernia challenges through AI: a dialogue with traditional guidelines: reply

Author: Wang, G., Chen, G., and Guo, C.
Published: 2024
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34. AI's deep dive into complex pediatric inguinal hernia issues: a challenge to traditional guidelines?

Author: Wang, G., Liu, Q., Chen, G., Xia, B., Zeng, D., Chen, G., and Guo, C.
Published: 2023
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35. Analysis of Ionomic Profiles of Spinal Cords in a Rat Model with Bone Cancer Pain

Author: Huang J, Chen J, Ma L, Zhu X, Wan L, Li X, and Guo C
Subjects: bone cancer pain, spinal cord, micronutrient, ionomic profile, Medicine (General), R5-920
Abstract: Jinlu Huang,1,&ast; Jiugeng Chen,2,&ast; Le Ma,3,&ast; Xieyi Zhu,4 Lili Wan,1 Xinyan Li,4 Cheng Guo1 1Department of Pharmacy, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 3Department of Pharmacy, Shanghai Jiao Tong University School of Medicine, Shanghai Mental Health Center, Shanghai, People’s Republic of China; 4College of Pharmacy, Shanghai Jiao Tong University, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xinyan Li; Cheng Guo, Email lixy@sjtu.edu.cn; guopharm@126.comBackground: Ionomics is used to study levels of ionome in different states of organisms and their correlations. Bone cancer pain (BCP) severely reduces quality of life of patients or their lifespan. However, the relationship between BCP and ionome remains unclear.Methods: The BCP rat model was constructed through inoculation of Walker 256 cells into the left tibia. Von Frey test, whole-cell patch-clamp recording and inductively coupled plasma mass spectrometry (ICP-MS) technologies were conducted for measuring tactile hypersensitivity, the frequency and amplitude of miniature excitatory postsynaptic currents (mEPSCs) of neurons of spinal slices, and ionome of spinal cord samples, respectively. Principal component analysis (PCA) was used to explore ionomic patterns of the spinal cord.Results: The BCP rat model was successfully constructed through implantation of Walker 256 cells into the left tibia. The frequency and amplitude of mEPSCs of neurons in the spinal cord slices from the BCP model rats were notably greater than those in the sham control. In terms of ionomics, the spinal cord levels of two macroelements (Ca and S), four microelements (Fe, Mn, Li and Sr) and the toxic element Ti in the BCP group of rats were significantly increased by inoculation of Walker 256 cancer cells, compared to the sham control. In addition, the correlation patterns between the elements were greatly changed between the sham control and BCP groups. PCA showed that inoculation of Walker 256 cells into the tibia altered the overall ionomic profiles of the spinal cord. There was a significant separation trend between the two groups.Conclusion: Taken together, inoculation of Walker 256 cells into the left tibia contributes to BCP, which could be closely correlated by some elements. The findings provided novel information on the relationship between the ionome and BCP.Keywords: bone cancer pain, spinal cord, micronutrient, ionomic profile
Published: 2024

36. Short-Term Effect of Ambient Temperature in Acute Ischemic Stroke with Endovascular Treatment Due to Large Vessel Occlusion

Author: Liu J, Zhang M, Huang J, Guo C, Yang J, Yue C, Zi W, and Yang Q
Subjects: acute ischemic stroke, ambient temperature, large-vessel occlusion, endovascular treatment., Geriatrics, RC952-954.6
Abstract: Juan Liu,1,&ast; Min Zhang,2,&ast; Jiandi Huang,1,&ast; Changwei Guo,1 Jie Yang,1 Chengsong Yue,1 Wenjie Zi,1 Qingwu Yang1 1Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People’s Republic of China; 2Department of Neurology, Jiangmen Central Hospital, Jiangmen, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qingwu Yang; Wenjie Zi, Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People’s Republic of China, Email yangqwmlys@163.com; ziwenjie@126.comPurpose: Acute ischemic stroke (AIS) stands as the primary cause of mortality and extended disability globally. While prior studies have examined the connection between stroke and local weather, they have produced conflicting results. Our goal was to examine the correlation between temperature and functional prognosis in patients with large vessel occlusion (LVO) undergoing endovascular therapy (EVT).Patients and methods: This study included a total of 1809 patients. Temperatures from stroke onset to groin puncture were categorized into Cold (10th percentile of temperature), Cool (10th– 50th percentile of temperature), Warm (50th– 90th percentile of temperature), and Hot (90th percentile of temperature) groups. The primary efficacy result was the modified Rankin Scale (mRS) score at 90 days. Safety outcomes included mortality, symptomatic intracranial hemorrhage (sICH) and complications after cerebral infarction.Results: The primary efficacy results demonstrated a statistical enhancement in functional outcomes at 90 days for patients in the Warm group compared to the Cold group (adjusted common odds ratio [OR]: 1.386; 95% confidence interval [CI]: 1.024– 1.878, P=0.035). Secondary efficacy results showed that temperature was associated with a higher rate of 90-day functional independence (adjusted OR: 1.016; 95% CI: 1.004– 1.029; P=0.009), which was higher in the Warm group compared with patients in the Cold group (adjusted OR: 1.646; 95% CI: 1.107– 2.448, P=0.014). There were no significant differences between groups in terms of sICH, 90-day mortality, and post-infarction complications.Conclusion: Compared with Cold temperature, Warm temperature is associated with better functional outcomes and reduced mortality risk without increasing the risk of sICH.Keywords: acute ischemic stroke, ambient temperature, large-vessel occlusion, endovascular treatment
Published: 2024

37. Integrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats

Author: Zhou X, Wang X, Li J, Zhang M, Yang Y, Lei S, He Y, Yang H, Zhou D, and Guo C
Subjects: intracerebral hemorrhage, annao pingchong decoction, oxidative stress, network pharmacology, in vivo experiments, Therapeutics. Pharmacology, RM1-950
Abstract: Xuqing Zhou,1,2,&ast; Xu Wang,1,2,&ast; Jiaqi Li,3,&ast; Mengxue Zhang,4 Yi Yang,1 Shihui Lei,1 Ying He,3 Hua Yang,3 Desheng Zhou,4 Chun Guo1,2 1Experiment Center of Medical Innovation, the First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, 410007, People’s Republic of China; 2The First Clinical College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, 410007, People’s Republic of China; 3College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, People’s Republic of China; 4Department of Neurology, the First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, 410007, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chun Guo, Email chunguosm@163.comBackground: Annao Pingchong decoction (ANPCD) is a traditional Chinese decoction which has definite effects on treating intracerebral hemorrhage (ICH) validated through clinical and experimental studies. However, the impact of ANPCD on oxidative stress (OS) after ICH remains unclear and is worth further investigating.Aim: To investigate whether the therapeutic effects of ANPCD on ICH are related to alleviating OS damage and seek potential targets for its antioxidant effects.Materials and Methods: The therapeutic candidate genes of ANPCD on ICH were identified through a comparison of the target genes of ANPCD, target genes of ICH and differentially expressed genes (DEGs). Protein–protein interaction (PPI) network analysis and functional enrichment analysis were combined with targets-related literature to select suitable antioxidant targets. The affinity between ANPCD and the selected target was verified using macromolecular docking. Subsequently, the effects of ANPCD on OS and the selected target were further investigated through in vivo experiments.Results: Forty-eight candidate genes were screened, in which silent information regulator sirtuin 1 (SIRT1) is one of the core genes that has antioxidant effects and ICH significantly affected its expression. The good affinity between 6 compounds of ANPCD and SIRT1 was also demonstrated by macromolecular docking. The results of in vivo experiments demonstrated that ANPCD significantly decreased modified neurological severity scoring (mNSS) scores and serum MDA and 8-OHdG content in ICH rats, while significantly increasing serum SOD and CAT activity, complicated with the up-regulation of ANPCD on SIRT1, FOXO1, PGC-1α and Nrf2. Furthermore, ANPCD significantly decreased the apoptosis rate and the expression of apoptosis-related proteins (P53, cytochrome c and caspase-3).Conclusion: ANPCD alleviates OS damage and apoptosis after ICH in rats. As a potential therapeutic target, SIRT1 can be effectively regulated by ANPCD, as are its downstream proteins. Keywords: intracerebral hemorrhage, Annao Pingchong decoction, oxidative stress, network pharmacology, vivo experiments, SIRT1
Published: 2024

38. A study of liquid argon detector's $n$/$\gamma$ discrimination capability with PMT or SiPM readout

Author: Wang, L., Liu, Y., Guan, M. Y., Wang, T. A., Guo, C., Liu, J. C., Yang, C. G., Liang, X. H., and Chen, Y. D.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Liquid Argon (LAr) is used as a target material in several current and planned experiments related to dark matter direct searching and neutrino detection. Argon provides excellent Pulse Shape Discrimination (PSD) capability which could separate the electron recoil backgrounds from the expected nuclear recoil signals. This essay simulated the PSD capability of an LAr detector when PMTs or three kinds of SiPMs are used as photosensors based on the experimental data. The results show that the J-60035 SiPM could help the LAr detector achieve the highest PSD capability event though SiPM's After-Pulse (AP) and Cross-Talk (CT) deteriorate its PSD capability. In addition, the results also show that the effect from AP is greater than CT. This is instructive for selecting photosensors for LAr detectors., Comment: 15 pages, 8 figures
Published: 2022

39. Track-Based Triggers for Exotic Signatures

Author: Di Petrillo, K. F., Farr, J. N., Guo, C., Holmes, T. R., Nelson, J., and Pachal, K.
Subjects: High Energy Physics - Experiment
Abstract: Several compelling beyond the Standard Model scenarios predict signals that result in unconventional charged particle trajectories. Signatures for which unusual tracks are the most conspicuous feature pose significant challenges for experiments at the Large Hadron Collider (LHC), particularly for the trigger. This article presents a study of track-based triggers for a representative set of long-lived and unconventional signatures at the upcoming High Luminosity LHC. Scenarios studied include large multiplicities of low momentum tracks produced in a soft-unclustered-energy-pattern model, displaced leptons and anomalous prompt tracks predicted in a Supersymmetry model with long-lived staus, and displaced hadrons predicted in a Higgs portal scenario with long-lived scalars. Trigger efficiency is measured as a function of the baseline parameters of a track trigger, including transverse momentum and impact parameter. Recommendations for future hardware-based track triggers are presented., Comment: Snowmass submission
Published: 2022

40. Efficient generation of high-order harmonics in gases

Author: Weissenbilder, R., Carlström, S., Rego, L., Guo, C., Heyl, C. M., Smorenburg, P., Constant, E., Arnold, C. L., and L'Huillier, A.
Subjects: Physics - Optics, Physics - Atomic Physics
Abstract: High-order harmonic generation (HHG) in gases leads to short-pulse extreme ultraviolet (XUV) radiation useful in a number of applications, for example, attosecond science and nanoscale imaging. However, this process depends on many parameters and there is still no consensus on how to choose the target geometry to optimize the source efficiency. Here, we review the physics of HHG with emphasis on the macroscopic aspects of the nonlinear interaction. We analyze the influence of medium length, pressure, position of the medium and intensity of the driving laser on the HHG conversion efficiency (CE), using both numerical modelling and analytical expressions. We find that efficient high-order harmonic generation can be realized over a large range of pressures and medium lengths, if these follow a certain hyperbolic equation. The spatial and temporal properties of the generated radiation are, however, strongly dependent on the choice of pressure and medium length. Our results explain the large versatility in gas target design for efficient HHG and provide design guidance for future high-flux XUV sources., Comment: 15 pages, 10 figures
Published: 2022

41. Pyroptosis-Related Gene Signature Predicts Prognosis and Response to Immunotherapy and Medication in Pediatric and Young Adult Osteosarcoma Patients

Author: Guo C, Yang X, and Li L
Subjects: target, nomogram model, immune microenvironment, drug sensitivity, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Chaofan Guo,1,2,&ast; Xin Yang,3,&ast; Lijun Li1,2 1Department of Orthopedics, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi Province, People’s Republic of China; 2Department of Spine Surgery, Fifth Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, People’s Republic of China; 3Department of Neurosurgery, Chongqing Fourth People’s Hospital, Chongqing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lijun Li, Department of Orthopedics, Shanxi Provincial People’s Hospital, Shuangtasi Street No. 29, Taiyuan, 030012, People’s Republic of China, Tel +86 0351-4960081, Email llj_110707152021@163.comPurpose: Pyroptosis, a new form of inflammatory programmed cell death, has recently gained attention. However, the impact of the expression levels of pyroptosis-related genes (PRGs) on the overall survival (OS) of osteosarcoma patients remains unclear. This study aims to investigate the impact of the expression levels of PRGs on the OS of pediatric and young adult patients with osteosarcoma.Patients and Methods: Transcriptome matrix datasets of normal muscle or skeletal tissues from the Genotype-Tissue Expression (GTEx) project and osteosarcoma specimen the National Cancer Institute’s (NCI) Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database were used to identify pyroptosis-related genes (PRGs) associated with prognosis. The National Center for Biotechnology Information’s (NCBI) GSE21257 dataset was employed to validate the predictive value of the pyroptosis-related signature (PRS). Additionally, reverse transcription polymerase chain reaction (RT-qPCR) experiment was performed in normal and osteosarcoma cell lines.Results: The study identified 18 differentially expressed PRGs (DEPRGs) between normal muscle or skeletal tissues and tumor samples. Multiple machine learning techniques were used to select PRGs, resulting in the identification of four hub PRGs. A PRS-score was calculated for each sample based on the expression of these four hub PRGs, and samples were categorized into low and high PRS-score level groups. It was confirmed that metastatic status and PRS-score level are independent prognostic predictors. A nomogram model for predicting OS of osteosarcoma patients was constructed. Single-cell RNA-sequencing data display the expression patterns of the hub PRGs. RT-qPCR data results were found to be consistent with the differential expression analysis performed on TARGET and GTEx samples.Conclusion: The study developed a novel pyroptosis-related gene signature that can stratify pediatric and young adult osteosarcoma patients into different risk groups, thus predicting their response to immunotherapy and chemotherapy.Keywords: TARGET, nomogram model, immune microenvironment, drug sensitivity
Published: 2024

42. Effect of High-Fat Meal on the Pharmacokinetics and Safety of Valsartan/Amlodipine Fixed Dose Combination Tablets in Healthy Subjects

Author: Song H, Qiu B, Sun X, Guo C, Hu Y, Bai W, and Dong Z
Subjects: amlodipine, valsartan, high fat meal, pharmacokinetics, Therapeutics. Pharmacology, RM1-950
Abstract: Haojing Song, Bo Qiu, Xue Sun, Caihui Guo, Yiting Hu, Wanjun Bai, Zhanjun Dong Department of Medicine, Hebei General Hospital, Shijiazhuang, 050051, People’s Republic of ChinaCorrespondence: Wanjun Bai; Zhanjun Dong, Department of Medicine, Hebei General Hospital, Shijiazhuang, 050051, People’s Republic of China, Tel +86-0311-85988326 ; +86-0311-85988604, Fax +86-0311-85988604, Email baiwanjun0311@163.com; yqlcdzj@163.comBackground: The objective of this study was to evaluate the effect of a high-fat meal on the pharmacokinetics and safety of 80/5 mg valsartan/amlodipine tablets in healthy subjects.Subjects and Methods: These results were derived from a bioequivalence trial where subjects were randomly assigned to take valsartan/amlodipine 80/5mg under fed conditions or after a high-fat meal contained 978.6 kilocalories (54.6% from fat). The blood samples were collected and plasma concentrations of valsartan/amlodipine were measured using high-performance liquid chromatography-mass spectrometry. The non-compartmental module of Phoenix WinNonlin Version 8.2 was used to calculate pharmacokinetic parameters. The BE module of WinNonLin was used to analyze the statistics of the maximum plasma concentration (Cmax), the area under the concentration-time curve from zero to the last quantifiable time point (AUC0-t), and the area under the concentration-time curve from zero to infinity(AUC0–∞) in plasma. 88 healthy subjects were enrolled and divided into in a fasted group and a fed group.Results: The Cmax, AUC0–t, and AUC0–∞ of valsartan in plasma under fed conditions were 51%, 56%, and 57% lower, respectively, than those under fasted conditions, and the 90% confidence interval (90% CI) were outside the 80.00– 125.00% range. All the pharmacokinetic parameters for amlodipine under fed conditions were similar to those observed under fasted conditions, and the 90% CIs were within the 80.00– 125.00% range. The incidence of treatment emergent adverse events (TEAE) was similar between the fasted group and the fed group, while adverse drug reaction (ADR) was more frequent in the fasted group which may be related to the higher blood concentrations of valsartan, but all were mild.Conclusion: The result indicated that the high-fat meal had a significant effect on the pharmacokinetics of valsartan, but no effect on amlodipine. All treatments were safe and well tolerated in healthy subjects under fed and fasted conditions.Keywords: amlodipine, valsartan, high-fat meal, pharmacokinetics
Published: 2024

43. Claudin-2 Mediates the Proximal Tubular Epithelial Cell–Fibroblast Crosstalk via Paracrine CTGF

Author: Guo C, Jiao M, Cui Y, Li P, Yao J, Dong J, and Liao L
Subjects: proximal tubular epithelial cell, fibroblast, crosstalk, diabetic kidney disease, claudin-2, Specialties of internal medicine, RC581-951
Abstract: Congcong Guo,1– 4 Mingwen Jiao,5 Yuying Cui,1– 4 Pingjiang Li,6 Jinming Yao,1– 3 Jianjun Dong,7 Lin Liao1– 4 1Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, People’s Republic of China; 2Shandong Key Laboratory of Rheumatic Disease and Translational medicine, Shandong Institute of Nephrology, Jinan, Shandong, People’s Republic of China; 3Shandong Institute of Nephrology, the First Affiliated Hospital of Shandong First Medical University& Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, People’s Republic of China; 4Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China; 5Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, People’s Republic of China; 6Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, People’s Republic of China; 7Department of Endocrinology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of ChinaCorrespondence: Lin Liao, Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, People’s Republic of China, Tel +86 15168888260, Email liaolin@sdu.edu.cn Jianjun Dong, Department of Endocrinology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China, Tel +86 13791122910, Email dongjianjun@sdu.edu.cnPurpose: Proximal tubular epithelial cell (PTEC) is vulnerable to injury in diabetic kidney disease (DKD) due to high energy expenditure. The injured PTECs-derived profibrotic factors are thought to be driving forces in tubulointerstitial fibrosis (TIF) as they activate surrounding fibroblasts. However, the mechanisms remain unclear.Methods: The diabetes with uninephrectomy (DKD) rats were used to evaluated renal histological changes and the expression of Claudin-2 by immunofluorescence staining. Then, Claudin-2 expression in PTECs were modulated and subsequently determined the proliferation and activation of fibroblasts by building a transwell co-culture system in normal glucose (NG)or high glucose (HG) condition.Results: Decreased expression of Claudin-2 in PTECs accompanied by tight junction disruption and increased interstitial fibrosis, were detected in DKD rats. In vitro, downregulated Claudin-2 in PTECs promoted proliferation and activation of fibroblasts, which coincided with elevated expression of profibrotic connective tissue growth factor (CTGF) in PTECs. Silenced CTGF inhibited the profibrotic of PTECs via Claudin-2 inhibition. Fibroblasts co-cultured with PTECs transitioned more to myofibroblasts and generated extracellular matrix (ECM) significantly in response to high glucose (HG) stimulation whereas overexpression of Claudin-2 in PTECs reversed the above results. Upregulating CTGF disrupted the beneficial anti-fibrosis effects obtained by overexpression of Claudin-2 in HG condition.Conclusion: Our study suggested that Claudin-2 in PTECs, a key mediator of paracellular cation and water transport, promotes the activation and proliferation of surrounding fibroblasts significantly via CTGF in a paracrine manner.Keywords: proximal tubular epithelial cell, fibroblast, crosstalk, diabetic kidney disease, Claudin-2
Published: 2024

44. Peculiar disk behaviors of the black hole candidate MAXI J1348-630 in the hard state observed by Insight-HXMT and Swift

Author: Zhang, W., Tao, L., Soria, R., Qu, J. L., Zhang, S. N., Weng, S. S., zhang, L., Wang, Y. N., Huang, Y., Ma, R. C., Zhang, S., Ge, M. Y., Song, L. M., Ma, X., Bu, Q. C., Cai, C., Cao, X. L., Chang, Z., Chen, L., Chen, T. X., Chen, Y. B., Chen, Y., Chen, Y. P., Cui, W. W., Du, Y. Y., Gao, G. H., Gao, H., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Huo, J., Jia, S. M., Jiang, W. C., Jin, J., Kong, L. D., Li, B., Li, C. K., Li, G., Li, T. P., Li, W., Li, X., Li, X. B., Li, X. F., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, B. S., Liu, C. Z., Liu, H. X., Liu, H. W., Liu, X. J., Lu, F. J., Lu, X. F., Luo, Q., Luo, T., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Ren, X. Q., Sai, N., Song, X. Y., Sun, L., Tan, Y., Tuo, Y. L., Wang, C., Wang, L. J., Wang, P. J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. Y., Wu, B. B., Wu, M., Xiao, G. C., Xiao, S., Xiong, S. L., Yang, R. J., Yang, S., Yang, Y. J., Yang, Y. R., Yi, Q. B., Yin, Q. Q., Yuan, Y., Zhang, F., Zhang, H. M., Zhang, P., Zhang, W. C., Zhang, Y. F., Zhang, Y. H., Zhao, H. S., Zhao, X. F., Zheng, S. J., Zheng, Y. G., and Zhou, D. K.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present a spectral study of the black hole candidate MAXI J1348-630 during its 2019 outburst, based on monitoring observations with Insight-HXMT and Swift. Throughout the outburst, the spectra are well fitted with power-law plus disk-blackbody components. In the soft-intermediate and soft states, we observed the canonical relation L ~ T_in^4 between disk luminosity L and peak colour temperature T_in, with a constant inner radius R_in (traditionally identified with the innermost stable circular orbit). At other stages of the outburst cycle, the behaviour is more unusual, inconsistent with the canonical outburst evolution of black hole transients. In particular, during the hard rise, the apparent inner radius is smaller than in the soft state (and increasing), and the peak colour temperature is higher (and decreasing). This anomalous behaviour is found even when we model the spectra with self-consistent Comptonization models, which take into account the up-scattering of photons from the disk component into the power-law component. To explain both those anomalous trends at the same time, we suggest that the hardening factor for the inner disk emission was larger than the canonical value of ~1.7 at the beginning of the outburst. A more physical trend of radii and temperature evolution requires a hardening factor evolving from ~3.5 at the beginning of the hard state to ~1.7 in the hard intermediate state. This could be evidence that the inner disk was in the process of condensing from the hot, optically thin medium and had not yet reached a sufficiently high optical depth for its emission spectrum to be described by the standard optically-thick disk solution., Comment: 20 pages, 10 figures, 4 tables, accepted by ApJ
Published: 2022
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45. CMOS pixel sensors optimized for large ionizing dynamic

Author: Ren, W., Baudot, J., Federici, L., Finck, C., Hu-Guo, C., Kachel, M., Reidel, C. -A., Schui, C., Sefri, R., Spiriti, E., Weber, U., and Zhao, Y.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Monolithic active pixel sensors (MAPS) are now well established as a technology for tracking charged particles, especially when low material budget is desirable. For such applications, sensors focus on spatial resolution and pixels with digital output or modest charge measurement ability are well suited. Within the European Union STRONG-2020 project, which focuses on experiments using hadrons, the TIIMM (Tracking and Ions Identifications with Minimal Material budget) joint research activity intends to expand granular MAPS capacity to energy-loss ({\Delta}E) measurement for ion species identification. The TIIMM prototypes are developed in the Tower Jazz 180 nm CMOS image sensor (CIS) process. The Time-Over-Threshold (ToT) method is applied to the sensor for the energy-loss measurement. The main design details and the preliminary test results from laboratory measurements of the initial TIIMM prototype are presented in this work., Comment: 4 pages
Published: 2022
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46. Bimetallic Ratio Strategy for Efficient Photocatalytic Hydrogen Production

Author: Niu, F., He, Q., Wu, S., Guo, C., Lei, W., and Shen, Y.
Published: 2023
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47. Big Data-Enabled Analysis of Factors Affecting Medical Expenditure in the Cerebral Infarction of a Developing City in Western China

Author: Zeng S, Zhang Y, Guo C, Zhou X, and He X
Subjects: medical expenditure, cerebral infarction, influencing factors, reimbursement mechanism, Public aspects of medicine, RA1-1270
Abstract: Siyu Zeng,1 Ying Zhang,2 Chuijiang Guo,1 Xia Zhou,1 Xiaozhou He3 1School of Logistics, Chengdu University of Information Technology, Chengdu, Sichuan, People’s Republic of China; 2General Practice Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 3Business School, Sichuan University, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Xiaozhou He, Business School, Sichuan University, No. 24 South Section 1, Yihuan Road, Chengdu, Sichuan, 610065, People’s Republic of China, Tel +86-18512811267, Email xiaozhouhe126@qq.comPurpose: Cerebral infarction (CI) has been one of the leading causes of death in China since 2017, and controlling the medical expenses of this disease is an urgent issue for the Chinese government. This study aims to explore the important factors that affect the hospitalization expenses of CI patients and to provide a scientific basis for establishing a reasonable reimbursement mechanism and hospitalization expense standard for CI patients.Methods: Data from 109,314 inpatients from the Healthcare Security Administration of Chengdu in western China from January 2016 to December 2018 were utilized. Descriptive statistical analysis was used for variable characteristic analysis. The Mann–Whitney test and Kruskal–Wallis test were used for single-factor analysis, and multiple linear stepwise regression was used for single-factor analysis and multiple-factor analysis.Results: This study found that the average direct economic burden of CI in Chengdu was approximately 10,569 Chinese yuan (CNY), about 1450 US dollars, the average length of stay (LOS) was 14.47 days, the indirect economic burden was approximately 2817 CNY, and the total economic burden was 13,386 CNY for a CI inpatient. Gender, insurance type, grade of medical institution, the level of payment type, age, LOS, and complications and comorbidities (CCs) are the most important factors affecting CI medical costs.Conclusion: Citizens should improve their lifestyle habits to reduce disease risk to avoid the associated medical and economic burdens. Hospitals should improve their medical technology to decrease the LOS and reduce direct medical costs. The government should actively promote the hierarchical diagnosis and treatment policy to reduce the waste of medical resources caused by low-acuity patients going to high-level hospitals for treatment. The National Healthcare Security Administration should optimize the medical insurance payment method and establish a corresponding mechanism to reduce the occurrence of excessive medical treatments such as overuse.Keywords: medical expenditure, cerebral infarction, influencing factors, reimbursement mechanism
Published: 2023

48. A Study on the radon removal performance of low background activated carbon

Author: Chen, Y. Y., Zhang, Y. P., Liu, Y., Liu, J. C., Guo, C., Zhang, P., Qiu, S. K., Yang, C. G., and Tang, Q.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Radon and radon daughters pose significant backgrounds to rare-event searching experiments. Activated carbon, which has very strong adsorption capacity for radon, can be used for radon removal and radon enrichment. The internal $^{226}$Ra concentration ultimately limits its radon enrichment ability. In order to measure the intrinsic background and study the radon adsorption capability of Saratech activated carbon at various temperatures, a radon-emanation measurement system with a high-sensitivity radon detector and an adsorption-performance research-system have been developed. In this paper, a 0.71~mBq/m$^3$ high-sensitivity radon detector and measurement details of the radon-adsorption capability of Saratech activated carbon at low temperature will be presented., Comment: 16 pages,11figures
Published: 2021
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49. Search for Gamma-Ray Bursts and Gravitational Wave Electromagnetic Counterparts with High Energy X-ray Telescope of \textit{Insight}-HXMT

Author: Cai, C., Xiong, S. L., Li, C. K., Liu, C. Z., Zhang, S. N., Li, X. B., Song, L. M., Li, B., Xiao, S., Yi, Q. B., Zhu, Y., Zheng, Y. G., Chen, W., Luo, Q., Huang, Y., Song, X. Y., Zhao, H. S., Zhao, Y., Zhang, Z., Bu, Q. C., Cao, X. L., Chang, Z., Chen, L., Chen, T. X., Chen, Y. B., Chen, Y., Chen, Y. P., Cui, W. W., Du, Y. Y., Gao, G. H., Gao, H., Ge, M. Y., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Huo, J., Jia, S. M., Jiang, W. C., Jin, J., Kong, L. D., Li, G., Li, T. P., Li, W., Li, X., Li, X. F., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, B. S., Liu, H. W., Liu, H. X., Liu, X. J., Lu, F. J., Lu, X. F., Luo, T., Ma, R. C., Ma, X., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Qu, J. L., Ren, X. Q., Sai, N., Sun, L., Tan, Y., Tao, L., Tuo, Y. L., Wang, C., Wang, L. J., Wang, P. J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. B., Wu, B. Y., Wu, M., Xiao, G. C., Xu, Y. P., Yang, R. J., Yang, S., Yang, Y. J., Yang, Y. R., Yang, X. J., Yin, Q. Q., You, Y., Zhang, F., Zhang, H. M., Zhang, J., Zhang, P., Zhang, S., Zhang, W. C., Zhang, W., Zhang, Y. F., Zhang, Y. H., Zhao, X. F., Zheng, S. J., and Zhou, D. K.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The High Energy X-ray telescope (HE) on-board the Hard X-ray Modulation Telescope (\textit{Insight}-HXMT) can serve as a wide Field of View (FOV) gamma-ray monitor with high time resolution ($\mu$s) and large effective area (up to thousands cm$^2$). We developed a pipeline to search for Gamma-Ray Bursts (GRBs), using the traditional signal-to-noise ratio (SNR) method for blind search and the coherent search method for targeted search. By taking into account the location and spectrum of the burst and the detector response, the targeted coherent search is more powerful to unveil weak and sub-threshold bursts, especially those in temporal coincidence with Gravitational Wave (GW) events. Based on the original method in literature, we further improved the coherent search to filter out false triggers caused by spikes in light curves, which are commonly seen in gamma-ray instruments (e.g. \textit{Fermi}/GBM, \textit{POLAR}). We show that our improved targeted coherent search method could eliminate almost all false triggers caused by spikes. Based on the first two years of \textit{Insight}-HXMT/HE data, our targeted search recovered 40 GRBs, which were detected by either \textit{Swift}/BAT or \textit{Fermi}/GBM but too weak to be found in our blind search. With this coherent search pipeline, the GRB detection sensitivity of \textit{Insight}-HXMT/HE is increased to about 1.5E-08 erg/cm$^2$ (200 keV$-$3 MeV). We also used this targeted coherent method to search \textit{Insight}-HXMT/HE data for electromagnetic (EM) counterparts of LIGO-Virgo GW events (including O2 and O3a runs). However, we did not find any significant burst associated with GW events., Comment: 12 pages, 14 figures, 5 tables; accepted for publication in MNRAS
Published: 2021
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50. Association between garden work and risk of incident dementia in an older population in China: a national cohort study

Author: Wang, J., Liu, D., Guo, C., Duan, Y., Hu, Z., Tian, M., Xu, Q., Niu, Y., and Yan, G.
Published: 2024
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