Search

Your search keyword '"Guimond, Jean"' showing total 50 results
Start Over Author "Guimond, Jean" Publication Year Range Last 10 years
50 results on '"Guimond, Jean"'

2. The authors reply

Author

Angriman, Federico, Muttalib, Fiona, Lamontagne, François, Adhikari, Neill K. J., Chassé, Michaël, Aslanian, Pierre, Bélisle, Sylvain, Cailhier, Jean-François, Martin Carrier, François, Charbonney, Emmanuel, Denault, André, Girard, Martin, Guimond, Jean-Gilles, Halwagi, Antoine, Hébert, Paul, Kolan, Christophe, Ouellet, Caroline, Robillard, Nicholas, Benettaib, Fatna, Boumahni, Dounia, Lebrasseur, Martine, Salamé, Maya, Cantin, Marie-Ève, Archambault, Patrick, Drouin, Christine, Duquet-Deblois, Estel, Noël-Hunter, Monia, Dubé, Jean-Nicolas, Bériault, Marie-Josée, Chacon, Marco, Claveau, David, Naud, Jean-François, Rodrigue, Élise, Tapss, Danielle, Toupin, Guylaine, Ting Wang, Han, Brosseau, Marc, Laufer, Brian, Marquis, François, Toupin, Francis, Tassy, Danaë, Cheung, Vincent, Toun, Sam-Ang, Lamontagne, François, D’Aragon, Frédérick, Bérard, Dominique, Grondin-Beaudoin, Brian, Leclair, Marc-André, Lesur, Olivier, Mayette, Michaël, Poulin, Yannick, Quiroz Martinez, Hector, St-Arnaud, Charles, Carbonneau, Elaine, Bélisle, Julie, Bouchard, Marie-Pier, Côté, Line, Ladouceur, Marylène, Marchand, Joannie, Naisby, Alexandra, Robert-Petit, Louise, Thibault, Marie-Ève, Charbonney, Emmanuel, Albert, Martin, Bernard, Francis, Cavayas, Alexandros, Serri, Karim, Williamson, David, Williams, Virginie, Lainer Palacios, Julia, Lauzier, François, Francoeur, Charles, Leblanc, Guillaume, St-Onge, Maude, Turgeon, Alexis, Bellemare, David, Boulanger, Marie-Claude, Cloutier, Eve, Guilbault, Gabrielle, Thibeault, Frédérique, Belley-Côté, Emilie, Fox-Robichaud, Alison, Meade, Maureen, Whitlock, Richard, Hand, Lori, Hayward, Leah, Mullen, Courtney, Savija, Nevena, Lellouche, François, Simon, Mathieu, Tung Sia, Ying, Lizotte, Patricia, Rochwerg, Bram, Millen, Tina, Maslove, David, Gordon Boyd, J., Drover, John, Muscedere, John, Sibley, Stephanie, Boyd, Tracy, Hunt, Miranda, Mele, Tina, Bentall, Tracey, ElKhatib, Chadia, Shahin, Jason, Khwaja, Kosar, Campisi, Josie, Alam, Norine, Rahgoshai, Raham, Mehta, Sangeeta, Detsky, Michael, Shah, Sumesh, Kohli, Sonny, Cui, Fulan, Khera, Vikas, McConachie, David, Rehsia, Sachdeep, Bharti, Dalisha, Perez, Adic, James Kutsogiannis, Demetrios, Chowdhury, Raiyan, Davidow, Jon, Johnston, Curtis, Kim, Michael, Macala, Kimberley, Marcushamer, Sam, Markland, Darren, Matheson, Doug, Parker, Arabesque, Paton-Gay, Damian, Hewer, Tayne, Thompson, Patrica, Cook, Deborah, Al-Hazzani, Waleed, Duan, Erick, Ligori, Tania, Soth, Mark, Clarke, France, Copland, Mary, Matic, Karlo, Adhikari, Neill KJ, Amaral, Andre, Cuthbertson, Brian H, Fowler, Robert A, Piquette, Dominique, Scales, Damon C, Tillmann, Bourke, Wunsch, Hannah, Marinoff, Nicole, Kamra, Maneesha, Kaur, Navjot, Murali, Deeptha, Sabananthan, Thivya, Sugumaran, Thuva, Seely, Andrew, English, Shane, Meggison, Hilary, Microys, Sherissa, Millington, Scott, Sarti, Aimee, Haines, Jessica, Miezitis, Sydney, Porteous, Rebecca, Watpool, Irene, Del Sorbo, Lorenzo, Fan, Eddy, Granton, John, Abdelhady, Hesham, Romagnuolo, Tina, Rewa, Oleksa, Bagshaw, Sean, Meier, Michael, Sligl, Wendy, Baig, Nadia, Wood, Gordon, Ovakim, Daniel, Auld, Fiona, Carney, Gayle, Parfett, Deborah, Leblanc, Rémi, Poirier, Matthieu, Theriault, Theophile, Williston, Maryse, Caissie Collette, Jackie, Carriere, Melanie, Daigle, Melissa, Gaudet, Bernise, Morin, Karine, Ouellette-Bernier, Lola, Poitras, Julie, Robichaud, Melanie, Rockburn, Joanne, Mekontso Dessap, Armand, Arrestier, Romain, Bagate, François, Bendib, Ines, Benelli, Brice, Berti, Enora, Bertier, Astrid, Cavaleiro, Pedro, de Prost, Nicolas, Gendreau, Segolene, Hartman, Otto, Haudebourg, Anne-Fleur, Lopinto, Julien, Masi, Paul, Michaud, Gaël, Razazi, Keyvan, Tuffet, Samuel, Alves, Aline, Nait Chabane, Luiza, Ouali, Fariza, Ouedraogo, Rachida, Annane, Djillali, Abdeladim, Lilia, Bounab, Rania, Heming, Nicholas, Maxime, Virginie, Moine, Pierre, Bossard, Isabelle, Jourdier, Segolene, Mahiou, Siline, Tessa, Hayette, McGuinness, Shay, Ball, Jonathan, Hennessy, Immanuel, Hogan, Maurice, Butler, Magdalena, Cowdrey, Keri-Anne, Gilder, Eileen, Parke, Rachael, Ryan, Samantha, Woollett, Melissa, Van Der Poll, Andrew, Benson-Cooper, Kerry, Chen, Jonathan, Freeman, Kirk, Harley, David, Harvey, Dave, Hourigan, Craig, Julian, Kylie, Lo, Stephen, McArthur, Colin, Miller, Stuart, Pointer, Chris, Anthony Smith, Rex, Tincknell, Laura, McConnochie, Rachael, Simmonds, Catherine, Shaw, Geoffrey, Betteridge, Toby, Burke, Brandon, Closey, David, Crombie, Rosalind, Davidson, Neil, Henderson, Louise, Henderson, Seton, Hitchings, Louise, Knight, David, Quigley, Christine, Ritzema Carter, Jay, Roberts, Jessica, Townend, Katherine, Doyle, Tara, Mehrtens, Jan, Morgan, Stacey, Morris, Anna, Van Der Heyden, Kymbalee, Twardowski, Pawel, Dvoracek, Martin, Renner, Markus, Silverman, David, Smith, Myles, Monica Stephens, Katherine, Albert Waibel, Hansjörg, Wiebe, Stefan, Woolley, Mark, Eden, Amie, France, Dawn, Buehner, Ulrike, Erin Williams, Katallah Kramer, Browne, Troy, Callender, Owen, Chen, Jonathan, Farrell, Susanne, Higson, Vicky, Jackson, David, Keet, Owen, Goodson, Jennifer, Martynoga, Robert, Byrne, Kelly, Butler, Amelia, Trask, Kara, Mans, Gay, Termaat, Jonathan, Young, Paul, Barnes, Colin, Barry, Ben, Grayson, Kim, Moore, James, Psirides, Alex, Sturland, Shawn, Tietjens, Kate, Ure, Bob, Walker, Laurence, Wright, Jason, Aguilar-Dano, April, Delaney, Kirsha, Lawrence, Cassie, Lesona, Mildred, Millington, Alexandra, Navarra, Leanlove, Olatunji, Shaanti, Sol Cruz, Raulle, Sol Cruz, Rhoze, Young, Chelsea, Day, Andrew, Cook, Deborah J, Guyatt, Gordon H, Sprague, Sheila, Cohen, Dian, Heyland, Daren K, Lamontagne, François, Masse, Marie-Hélène, Ménard, Julie, Adhikari, Neill KJ, Pinto, Ruxandra, Kanji, Salmaan, Battista, Marie-Claude, Annane, Djillali, Tirupakuzhi Vijayaraghavan, Bharath Kumar, McGuinness, Shay, Parke, Rachael, and Arabi, Yaseen

Published
2023
Full Text
View/download PDF

4. Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography

Author

Després, Audrey-Anne, Perrot, Nicolas, Poulin, Anthony, Tastet, Lionel, Shen, Mylène, Chen, Hao Yu, Bourgeois, Raphaëlle, Trottier, Mikaël, Tessier, Michel, Guimond, Jean, Nadeau, Maxime, Engert, James C, Thériault, Sébastien, Bossé, Yohan, Witztum, Joseph L, Couture, Patrick, Mathieu, Patrick, Dweck, Marc R, Tsimikas, Sotirios, Thanassoulis, George, Pibarot, Philippe, Clavel, Marie-Annick, and Arsenault, Benoit J

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Cardiovascular, Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis
Abstract

BackgroundLipoprotein(a) (Lp[a]) is the preferential lipoprotein carrier of oxidized phospholipids (OxPLs) and a well-established genetic risk factor for calcific aortic valve stenosis (CAVS). Whether Lp(a) predicts aortic valve microcalcification in individuals without CAVS is unknown. Our objective was to estimate the prevalence of elevated Lp(a) and OxPL levels in patients with CAVS and to determine if individuals with elevated Lp(a) but without CAVS have higher aortic valve microcalcification.MethodsWe recruited 214 patients with CAVS from Montreal and 174 patients with CAVS and 108 controls from Québec City, Canada. In a second group of individuals with high (≥75 nmol/L, n = 27) or low (

Published
2019

5. IV Vitamin C in Adults With Sepsis: A Bayesian Reanalysis of a Randomized Controlled Trial*

Author

Angriman, Federico, Muttalib, Fiona, Lamontagne, François, Adhikari, Neill K. J., Chassé, Michaël, Aslanian, Pierre, Bélisle, Sylvain, Cailhier, Jean-François, Carrier, François Martin, Charbonney, Emmanuel, Denault, André, Girard, Martin, Guimond, Jean-Gilles, Halwagi, Antoine, Hébert, Paul, Kolan, Christophe, Ouellet, Caroline, Robillard, Nicholas, Benettaib, Fatna, Boumahni, Dounia, Lebrasseur, Martine, Salamé, Maya, Cantin, Marie-Ève, Archambault, Patrick, Drouin, Christine, Dubé, Jean-Nicolas, Bériault, Marie-Josée, Chacon, Marco, Claveau, David, Naud, Jean-François, Rodrigue, Élise, Ting Wang, Han, Brosseau, Marc, Laufer, Brian, Marquis, François, Toupin, Francis, Lamontagne, François, D’Aragon, Frédérick, Bérard, Dominique, Grondin-Beaudoin, Brian, Leclair, Marc-André, Lesur, Olivier, Mayette, Michaël, Poulin, Yannick, Quiroz Martinez, Hector, St-Arnaud, Charles, Charbonney, Emmanuel, Albert, Martin, Bernard, Francis, Cavayas, Alexandros, Serri, Karim, Williamson, David, Duquet-Deblois, Estel, Noël-Hunter, Monia, Tapss, Danielle, Toupin, Guylaine, Tassy, Danaë, Cheung, Vincent, Toun, Sam-Ang, Carbonneau, Elaine, Bélisle, Julie, Bouchard, Marie-Pier, Côté, Line, Ladouceur, Marylène, Marchand, Joannie, Naisby, Alexandra, Robert-Petit, Louise, Thibault, Marie-Ève, Williams, Virginie, Lainer Palacios, Julia, Charbonney, Emmanuel, Albert, Martin, Bernard, Francis, Cavayas, Alexandros, Serri, Karim, Williamson, David, Lauzier, François, Francoeur, Charles, Leblanc, Guillaume, St-Onge, Maude, Turgeon, Alexis, Belley-Côté, Emilie, Fox-Robichaud, Alison, Meade, Maureen, Whitlock, Richard, Lellouche, François, Simon, Mathieu, Tung Sia, Ying, Rochwerg, Bram, Maslove, David, Gordon Boyd, J., Drover, John, Muscedere, John, Sibley, Stephanie, Mele, Tina, Shahin, Jason, Khwaja, Kosar, Mehta, Sangeeta, Detsky, Michael, Kohli, Sonny, Cui, Fulan, Khera, Vikas, McConachie, David, Rehsia, Sachdeep, James Kutsogiannis, Demetrios, Chowdhury, Raiyan, Davidow, Jon, Johnston, Curtis, Kim, Michael, Macala, Kimberley, Marcushamer, Sam, Markland, Darren, Matheson, Doug, Parker, Arabesque, Paton-Gay, Damian, Cook, Deborah, Al-Hazzani, Waleed, Duan, Erick, Ligori, Tania, Soth, Mark, Adhikari, Neill KJ, Amaral, Andre, Cuthbertson, Brian H, Fowler, Robert A, Piquette, Dominique, Scales, Damon C, Tillmann, Bourke, Wunsch, Hannah, Seely, Andrew, English, Shane, Meggison, Hilary, Microys, Sherissa, Millington, Scott, Sarti, Aimee, Del Sorbo, Lorenzo, Fan, Eddy, Granton, John, Rewa, Oleksa, Bagshaw, Sean, Meier, Michael, Sligl, Wendy, Wood, Gordon, Ovakim, Daniel, Leblanc, Rémi, Poirier, Matthieu, Theriault, Theophile, Williston, Maryse, Bellemare, David, Boulanger, Marie-Claude, Cloutier, Eve, Guilbault, Gabrielle, Thibeault, Frédérique, Hand, Lori, Hayward, Leah, Mullen, Courtney, Savija, Nevena, Lizotte, Patricia, Millen, Tina, Boyd, Tracy, Hunt, Miranda, Bentall, Tracey, ElKhatib, Chadia, Campisi, Josie, Alam, Norine, Rahgoshai, Raham, Shah, Sumesh, Bharti, Dalisha, Perez, Adic, Hewer, Tayne, Thompson, Patrica, Clarke, France, Copland, Mary, Matic, Karlo, Marinoff, Nicole, Kamra, Maneesha, Kaur, Navjot, Murali, Deeptha, Sabananthan, Thivya, Sugumaran, Thuva, Haines, Jessica, Miezitis, Sydney, Porteous, Rebecca, Watpool, Irene, Abdelhady, Hesham, Romagnuolo, Tina, Baig, Nadia, Auld, Fiona, Carney, Gayle, Parfett, Deborah, Caissie Collette, Jackie, Carriere, Melanie, Daigle, Melissa, Gaudet, Bernise, Morin, Karine, Ouellette-Bernier, Lola, Poitras, Julie, Robichaud, Melanie, Rockburn, Joanne, Mekontso Dessap, Armand, Arrestier, Romain, Bagate, François, Bendib, Ines, Benelli, Brice, Berti, Enora, Bertier, Astrid, Cavaleiro, Pedro, de Prost, Nicolas, Gendreau, Segolene, Hartman, Otto, Haudebourg, Anne-Fleur, Lopinto, Julien, Masi, Paul, Michaud, Gaël, Razazi, Keyvan, Tuffet, Samuel, Annane, Djillali, Abdeladim, Lilia, Bounab, Rania, Heming, Nicholas, Maxime, Virginie, Moine, Pierre, Alves, Aline, Nait Chabane, Luiza, Ouali, Fariza, Ouedraogo, Rachida, Bossard, Isabelle, Jourdier, Segolene, Mahiou, Siline, Tessa, Hayette, McGuinness, Shay, Ball, Jonathan, Hennessy, Immanuel, Hogan, Maurice, Van Der Poll, Andrew, Benson-Cooper, Kerry, Chen, Jonathan, Freeman, Kirk, Harley, David, Harvey, Dave, Hourigan, Craig, Julian, Kylie, Lo, Stephen, McArthur, Colin, Miller, Stuart, Pointer, Chris, Anthony Smith, Rex, Tincknell, Laura, Shaw, Geoffrey, Betteridge, Toby, Burke, Brandon, Closey, David, Crombie, Rosalind, Davidson, Neil, Henderson, Louise, Henderson, Seton, Hitchings, Louise, Knight, David, Quigley, Christine, Ritzema Carter, Jay, Roberts, Jessica, Townend, Katherine, Twardowski, Pawel, Dvoracek, Martin, Renner, Markus, Silverman, David, Smith, Myles, Monica Stephens, Katherine, Albert Waibel, Hansjörg, Wiebe, Stefan, Woolley, Mark, Buehner, Ulrike, Kramer, Katallah, Browne, Troy, Callender, Owen, Chen, Jonathan, Farrell, Susanne, Higson, Vicky, Jackson, David, Keet, Owen, Martynoga, Robert, Byrne, Kelly, Young, Paul, Barnes, Colin, Barry, Ben, Grayson, Kim, Moore, James, Psirides, Alex, Sturland, Shawn, Tietjens, Kate, Ure, Bob, Walker, Laurence, Wright, Jason, Butler, Magdalena, Cowdrey, Keri-Anne, Gilder, Eileen, Parke, Rachael, Ryan, Samantha, Woollett, Melissa, McConnochie, Rachael, Simmonds, Catherine, Doyle, Tara, Mehrtens, Jan, Morgan, Stacey, Morris, Anna, Van Der Heyden, Kymbalee, Eden, Amie, France, Dawn, Williams, Erin, Goodson, Jennifer, Butler, Amelia, Trask, Kara, Mans, Gay, Termaat, Jonathan, Aguilar-Dano, April, Delaney, Kirsha, Lawrence, Cassie, Lesona, Mildred, Millington, Alexandra, Navarra, Leanlove, Olatunji, Shaanti, Cruz, Raulle Sol, Cruz, Rhoze Sol, Young, Chelsea, Day, Andrew, Cook, Deborah J, Guyatt, Gordon H, Sprague, Sheila, Cohen, Dian, Heyland, Daren K, Lamontagne, François, Masse, Marie-Hélène, Ménard, Julie, Adhikari, Neill KJ, Pinto, Ruxandra, Kanji, Salmaan, Battista, Marie-Claude, Annane, Djillali, Vijayaraghavan, Bharath Kumar Tirupakuzhi, McGuinness, Shay, Parke, Rachael, and Arabi, Yaseen

Published
2023
Full Text
View/download PDF

11. Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells

Author

Yun, Tae Jin, Lee, Jun Seong, Machmach, Kawthar, Shim, Dahee, Choi, Junhee, Wi, Young Jin, Jang, Hyung Seok, Jung, In-Hyuk, Kim, Kyeongdae, Yoon, Won Kee, Miah, Mohammad Alam, Li, Bin, Chang, Jinsam, Bego, Mariana G., Pham, Tram N.Q., Loschko, Jakob, Fritz, Jörg Hermann, Krug, Anne B., Lee, Seung-Pyo, Keler, Tibor, Guimond, Jean V., Haddad, Elie, Cohen, Eric A., Sirois, Martin G., El-Hamamsy, Ismail, Colonna, Marco, Oh, Goo Taeg, Choi, Jae-Hoon, and Cheong, Cheolho

Published
2016
Full Text
View/download PDF

12. Generation of functional human T cell development in NOD/SCID/IL2rγnull humanized mice without using fetal tissue: Application as a model of HIV infection and persistence

Author

Colas, Chloé, primary, Volodina, Olga, additional, Béland, Kathie, additional, Pham, Tram N.Q., additional, Li, Yuanyi, additional, Dallaire, Frédéric, additional, Soulard, Clara, additional, Lemieux, William, additional, Colamartino, Aurélien B.L., additional, Tremblay-Laganière, Camille, additional, Dicaire, Renée, additional, Guimond, Jean, additional, Vobecky, Suzanne, additional, Poirier, Nancy, additional, Patey, Natasha, additional, Cohen, Éric A., additional, and Haddad, Elie, additional

Published
2023
Full Text
View/download PDF

14. Developmental role of macrophages modelled in human pluripotent stem cell derived intestinal tissue

Author

Song, Andrew T., primary, Sindeaux, Renata H. M., additional, Li, Yuanyi, additional, Affia, Hicham, additional, Agnihotri, Tapan, additional, Leclerc, Severine, additional, van Vliet, Patrick Piet, additional, Colas, Mathieu, additional, Guimond, Jean-Victor, additional, Patey, Natasha, additional, Joyal, Jean-Sebastien, additional, Haddad, Elie, additional, Barreiro, Luis, additional, and Andelfinger, Gregor, additional

Published
2022
Full Text
View/download PDF

15. Generation of Functional Human T Cell Development in NOD/SCID/IL2rγnull Humanized Mice Without Using Fetal Tissue: Application as a Model of HIV Infection and Persistence

Author

Colas, Chloe, primary, Volodina, Olga, additional, Beland, Kathie, additional, Pham, Tram N.Q., additional, Li, Yuanyi, additional, Dallaire, Frederic, additional, Soulard, Clara, additional, Lemieux, William, additional, Colamartino, Aurelien, additional, Tremblay-Laganiere, Camille, additional, Dicaire, Renee, additional, Guimond, Jean, additional, Patey, Natasha, additional, Vobecky, Suzanne, additional, Poirier, Nancy, additional, Cohen, Eric A., additional, and Haddad, Elie, additional

Published
2022
Full Text
View/download PDF

17. Stress Signal ULBP4, an NKG2D Ligand, Is Upregulated in Multiple Sclerosis and Shapes CD8+ T-Cell Behaviors

Author

Carmena Moratalla, Ana, primary, Carpentier Solorio, Yves, additional, Lemaitre, Florent, additional, Farzam-kia, Negar, additional, Levert, Annie, additional, Zandee, Stephanie E.J., additional, Lahav, Boaz, additional, Guimond, Jean Victor, additional, Haddad, Elie, additional, Girard, Marc, additional, Duquette, Pierre, additional, Larochelle, Catherine, additional, Prat, Alexandre, additional, and Arbour, Nathalie, additional

Published
2021
Full Text
View/download PDF

18. Non-invasive detection of a femoral-to-radial arterial pressure gradient in intensive care patients with vasoactive agents

Author

Jacquet-Lagrèze, Matthias, primary, Claveau, David, additional, Cousineau, Julie, additional, Liu, Kun Peng, additional, Guimond, Jean-Gilles, additional, Aslanian, Pierre, additional, Lamarche, Yoan, additional, Albert, Martin, additional, Charbonney, Emmanuel, additional, Hammoud, Ali, additional, Kontar, Loay, additional, and Denault, André, additional

Published
2021
Full Text
View/download PDF

19. Développement et validation de contenu d’un programme de rééducation du membre supérieur post AVC en ergothérapie

Author

Guimond, Jean-François, Desrosiers, Lyne, and Gélinas, Isabelle

Subjects
Stroke, Logic model, Rééducation du membre supérieur, Modèle logique, Ergothérapie, Thérapie axée sur la répétition de tâches fonctionnelles, Upper extremity rehabilitation, Intervention program, Programme d’intervention, Occupational therapy, Accident vasculaire cérébral, Task-Oriented Training
Abstract

Introduction. La thérapie axée sur la répétition de tâches fonctionnelles est préconisée pour la réadaptation du membre supérieur à la suite d’un accident vasculaire cérébral (AVC). Toutefois, aucun programme d’intervention n’opérationnalise l’ensemble des composantes clés du TOT en une démarche clinique valide de rééducation du membre supérieur post AVC en ergothérapie. Objectifs. 1) Établir la validité de contenu d’un programme de rééducation du membre supérieur post AVC en ergothérapie et 2) proposer un modèle logique de l’intervention qui fait consensus auprès d’experts et d’usagers. Méthodes. Un modèle logique d’un programme de rééducation du membre supérieur post AVC en ergothérapie a été développé, puis soumis à deux méthodes de recherche pour valider le contenu et obtenir un consensus d’experts et d’usagers : 1) Méthode Delphi : 14 experts ont examiné des capsules audiovisuelles illustrant le programme d’intervention et ont répondu à deux questionnaires pour valider les objectifs, la nature de l’intervention, les ressources, les activités et les extrants; 2) Technique de groupe nominal : six usagers ayant un vécu expérientiel de l’intervention ont généré les effets ciblés. L’indice de validité de contenu, deux indices d’accord interjuges et l’analyse de contenu ont été utilisés pour analyser les données. Résultats. Près de 93 % du contenu du programme de rééducation du membre supérieur post AVC en ergothérapie obtient un indice de validité satisfaisant, dont 82 % qui font consensus auprès d’experts et d’usagers dans un modèle logique révisé. Conclusion. Le modèle logique révisé propose une vision commune, quoiqu’incomplète, d’un programme de rééducation du membre supérieur post AVC en ergothérapie basé sur le TOT. Les activités et les extrants de l’évaluation devront faire l’objet de validation lors d’une phase subséquente d’implantation. Un transfert de connaissances sur les moyens pour favoriser le sentiment d’efficacité personnelle est aussi à prévoir pour réévaluer son rôle dans le programme d’intervention., Background. Task-Oriented Training (TOT) is the recommended approach for upper extremity rehabilitation after a stroke. To date, no program have operationalized all the key components of TOT into a valid upper extremity clinical rehabilitation process post stroke in occupational therapy. Objectives. 1) To determine the content validity of an upper extremity rehabilitation program post stroke in occupational therapy and 2) to propose a logic model reaching consensus among experts and patients. Methods. A logic model of an upper extremity rehabilitation program post stroke in occupational therapy was developed and validated. Two research methods were used to validate the content and to achieve a consensus of experts and patients : 1) Delphi method : 14 experts examined audiovisual capsules of the intervention and completed two questionnaires to validate the objectives, the nature of the intervention, the resources, the activities and the outputs; 2) Nominal group technique : six patients with experience of the intervention generated the outcomes. The content validity index, two interrater agreement statistics and a content analysis were used for data analysis. Results. Almost 93 % of the content of the upper extremity rehabilitation program post stroke in occupational therapy obtained a satisfactory validity index, including 82 % reaching consensus among experts and patients in a revised logic model. Conclusion. The revised logic model now offers a common, albeit incomplete, vision of an upper extremity rehabilitation program post stroke based on the TOT in occupational therapy. Activities and outputs of the evaluation should be validated during a subsequent implementation phase. Knowledge translation on the modalities to promote self-efficacy is also to be planned to reassess its role in the intervention program.

Published
2021

21. Autologous humanized mouse models of iPSC-derived tumors allow for the evaluation and modulation of cancer-immune cell interactions

Author

Moquin-Beaudry, Gaël, primary, Benabdallah, Basma, additional, Maggiorani, Damien, additional, Le, Oanh, additional, Li, Yuanyi, additional, Colas, Chloé, additional, Raggi, Claudia, additional, Ellezam, Benjamin, additional, M’Callum, Marie-Agnès, additional, Dal Soglio, Dorothée, additional, Guimond, Jean V., additional, Paganelli, Massimiliano, additional, Haddad, Elie, additional, and Beauséjour, Christian, additional

Published
2021
Full Text
View/download PDF

23. Genetic Variation in LPA, calcific aortic valve stenosis in patients undergoing cardiac surgery, and familial risk of aortic valve microcalcification

Author

Bilodeau, Anthony, Thériault, Sébastien, Dina, Christian, Nadeau, Maxime, Chen, Hao Yu, Arsenault, Benoit, Boekholdt, Stefan Matthijs, Trottier, Mikaël, Rigade, Sidwell, Capoulade, Romain, Després, Audrey-Anne, Guimond, Jean, Bossé, Yohan, Le Tourneau, Thierry, Pibarot, Philippe, Messika-Zeitoun, David, Perrot, Nicolas, Clavel, Marie-Annick, Tessier, Michel, Mathieu, Patrick, Engert, James, Khaw, Kay-Tee, Wareham, Nicholas J., Dweck, Marc, Schott, Jean-Jacques, Thanassoulis, George, Bilodeau, Anthony, Thériault, Sébastien, Dina, Christian, Nadeau, Maxime, Chen, Hao Yu, Arsenault, Benoit, Boekholdt, Stefan Matthijs, Trottier, Mikaël, Rigade, Sidwell, Capoulade, Romain, Després, Audrey-Anne, Guimond, Jean, Bossé, Yohan, Le Tourneau, Thierry, Pibarot, Philippe, Messika-Zeitoun, David, Perrot, Nicolas, Clavel, Marie-Annick, Tessier, Michel, Mathieu, Patrick, Engert, James, Khaw, Kay-Tee, Wareham, Nicholas J., Dweck, Marc, Schott, Jean-Jacques, and Thanassoulis, George

Abstract

IMPORTANCE: Genetic variants at the LPA locus are associated with both calcific aortic valve stenosis (CAVS) and coronary artery disease (CAD). Whether these variants are associated with CAVS in patients with CAD vs those without CAD is unknown. OBJECTIVE: To study the associations of LPA variants with CAVS in a cohort of patients undergoing heart surgery and LPA with CAVS in patients with CAD vs those without CAD and to determine whether first-degree relatives of patients with CAVS and high lipoprotein(a) (Lp[a]) levels showed evidence of aortic valve microcalcification. DESIGN, SETTING, AND PARTICIPANTS: This genetic association study included patients undergoing cardiac surgery from the Genome-Wide Association Study on Calcific Aortic Valve Stenosis in Quebec (QUEBEC-CAVS) study and patients with CAD, patients without CAD, and control participants from 6 genetic association studies: the UK Biobank, the European Prospective Investigation of Cancer (EPIC)-Norfolk, and Genetic Epidemiology Research on Aging (GERA) studies and 3 French cohorts. In addition, a family study included first-degree relatives of patients with CAVS. Data were collected from January 1993 to September 2018, and analysis was completed from September 2017 to September 2018. EXPOSURES: Case-control studies. MAIN OUTCOMES AND MEASURES: Presence of CAVS according to a weighted genetic risk score based on 3 common Lp(a)-raising variants and aortic valve microcalcification, defined as the mean tissue to background ratio of 1.25 or more, measured by fluorine 18-labeled sodium fluoride positron emission tomography/computed tomography. RESULTS: This study included 1009 individuals undergoing cardiac surgery and 1017 control participants in the QUEBEC-CAVS cohort; 3258 individuals with CAVS and CAD, 41 100 controls with CAD, 2069 individuals with CAVS without CAD, and 380 075 control participants without CAD in the UK Biobank, EPIC-Norfolk, and GERA studies and 3 French cohorts combined; and 33 first-de

Published
2020

24. Lipoprotein(a), oxidized phospholipids, and aortic valve microcalcification assessed by 18F-sodium fluoride positron emission tomography and computed tomography

Author

Bilodeau, Anthony, Thériault, Sébastien, Nadeau, Maxime, Arsenault, Benoit, Chen, Hao Yu, Bourgeois, Raphaëlle, Shen, Mylène, Trottier, Mikaël, Tessier, Michel, Després, Audrey-Anne, Guimond, Jean, Bossé, Yohan, Engert, James, Perrot, Nicolas, Couture, Patrick, Mathieu, Patrick, Witztum, Joseph L., Dweek, Marc, Bilodeau, Anthony, Thériault, Sébastien, Nadeau, Maxime, Arsenault, Benoit, Chen, Hao Yu, Bourgeois, Raphaëlle, Shen, Mylène, Trottier, Mikaël, Tessier, Michel, Després, Audrey-Anne, Guimond, Jean, Bossé, Yohan, Engert, James, Perrot, Nicolas, Couture, Patrick, Mathieu, Patrick, Witztum, Joseph L., and Dweek, Marc

Abstract

Background Lipoprotein(a) (Lp[a]) is the preferential lipoprotein carrier of oxidized phospholipids (OxPLs) and a well-established genetic risk factor for calcific aortic valve stenosis (CAVS). Whether Lp(a) predicts aortic valve microcalcification in individuals without CAVS is unknown. Our objective was to estimate the prevalence of elevated Lp(a) and OxPL levels in patients with CAVS and to determine if individuals with elevated Lp(a) but without CAVS have higher aortic valve microcalcification. Methods We recruited 214 patients with CAVS from Montreal and 174 patients with CAVS and 108 controls from Québec City, Canada. In a second group of individuals with high (≥75 nmol/L, n = 27) or low (<75 nmol/L, n = 28) Lp(a) levels, 18F-sodium fluoride positron emission tomography/computed tomography was performed to determine the difference in mean tissue-to-background ratio (TBR) of the aortic valve. Results Patients with CAVS had 62.0% higher Lp(a) (median = 28.7, interquartile range [8.2-116.6] vs 10.9 [3.6-28.8] nmol/L, P < 0.0001), 50% higher OxPL-apolipoprotein-B (2.2 [1.3-6.0] vs 1.1 [0.7-2.6] nmol/L, P < 0.0001), and 69.9% higher OxPL-apolipoprotein(a) (7.3 [1.8-28.4] vs 2.2 [0.8-8.4] nmol/L, P < 0.0001) levels compared with individuals without CAVS (all P < 0.0001). Individuals without CAVS but elevated Lp(a) had 40% higher mean TBR compared with individuals with low Lp(a) levels (mean TBR = 1.25 ± 0.23 vs 1.15 ± 0.11, P = 0.02). Conclusions Elevated Lp(a) and OxPL levels are associated with prevalent CAVS in patients studied in an echocardiography laboratory setting. In individuals with elevated Lp(a), evidence of aortic valve microcalcification by 18F-sodium fluoride positron emission tomography/computed tomography is present before the development of clinically manifested CAVS., La lipoprotéine(a) (Lp[a]), la principale lipoprotéine assurant le transport des phospholipides oxydés (PLOx), est un facteur de risque génétique bien établi de la sténose aortique calcifiante (SAC). On ignore si la présence de Lp(a) est un facteur prédictif de la microcalcification de la valve aortique chez les individus non atteints de SAC. Notre objectif était d'estimer la prévalence de taux élevés de Lp(a) et de PLOx chez des patients atteints de SAC et de déterminer si la microcalcification de la valve aortique est plus marquée chez les individus affichant des taux élevés de Lp(a) en l'absence de SAC. Méthodologie Nous avons recruté 214 patients atteints de SAC à Montréal et 174 patients atteints de SAC et 108 patients témoins à Québec (Canada). Dans un second groupe de patients présentant des taux de Lp(a) élevés (≥ 75 nmol/l, n = 27) ou faibles (< 75 nmol/l, n = 28), une tomographie par émission de positons au fluorure de sodium marqué au 18F a été réalisée en vue de comparer la valeur moyenne du rapport signal/bruit (RSB) de la valve aortique. Résultats Les patients atteints de SAC présentaient des taux de Lp(a) plus élevés de 62,0 % (médiane = 28,7, intervalle interquartile [de 8,2 à 116,6] vs 10,9 [de 3,6 à 28,8] nmol/l, p < 0,0001), des taux de OxPL-apolipoprotéine-B plus élevés de 50 % (2,2 [de 1,3 à 6,0] vs 1,1 [de 0,7 à 2,6] nmol/l, p < 0,0001) et des taux de PLOx-apolipoprotéine(a) plus élevés de 69,9 % (7,3 [de 1,8 à 28,4] vs 2,2 [de 0,8 à 8,4] nmol/l, p < 0,0001) comparativement aux patients non atteints de SAC (toutes les valeurs p < 0,0001). Les patients non atteints de SAC mais présentant des taux élevés de Lp(a) avaient un RSB moyen supérieur de 40 % à celui des individus affichant un faible taux de Lp(a) (RSB moyen = 1,25 ± 0,23 vs 1,15 ± 0,11, p = 0,02). Conclusions Des taux élevés de Lp(a) et de PLOx sont associés à la prévalence de la SAC chez des patients étudiés par échocardiographie. Chez les individus présentant un taux élevé de Lp(a), l

Published
2020

27. Genetic Variation in LPA, calcific aortic valve stenosis in patients undergoing cardiac surgery, and familial risk of aortic valve microcalcification

Author

Perrot, Nicolas, Thériault, Sébastien, Dina, Christian, Chen, Hao Yu, Boekholdt, Stefan Matthijs, Rigade, Sidwell, Després, Audrey-Anne, Poulin, Anthony, Capoulade, Romain, Le Tourneau, Thierry, Messika-Zeitoun, David, Trottier, Mikaël, Tessier, Michel, Guimond, Jean, Nadeau, Maxime, Engert, James, Khaw, Kay-Tee, Wareham, Nicholas J., Dweck, Marc, Mathieu, Patrick, Pibarot, Philippe, Schott, Jean-Jacques, Thanassoulis, George, Clavel, Marie-Annick, Bossé, Yohan, Arsenault, Benoit, Perrot, Nicolas, Thériault, Sébastien, Dina, Christian, Chen, Hao Yu, Boekholdt, Stefan Matthijs, Rigade, Sidwell, Després, Audrey-Anne, Poulin, Anthony, Capoulade, Romain, Le Tourneau, Thierry, Messika-Zeitoun, David, Trottier, Mikaël, Tessier, Michel, Guimond, Jean, Nadeau, Maxime, Engert, James, Khaw, Kay-Tee, Wareham, Nicholas J., Dweck, Marc, Mathieu, Patrick, Pibarot, Philippe, Schott, Jean-Jacques, Thanassoulis, George, Clavel, Marie-Annick, Bossé, Yohan, and Arsenault, Benoit

Abstract

IMPORTANCE: Genetic variants at the LPA locus are associated with both calcific aortic valve stenosis (CAVS) and coronary artery disease (CAD). Whether these variants are associated with CAVS in patients with CAD vs those without CAD is unknown. OBJECTIVE: To study the associations of LPA variants with CAVS in a cohort of patients undergoing heart surgery and LPA with CAVS in patients with CAD vs those without CAD and to determine whether first-degree relatives of patients with CAVS and high lipoprotein(a) (Lp[a]) levels showed evidence of aortic valve microcalcification. DESIGN, SETTING, AND PARTICIPANTS: This genetic association study included patients undergoing cardiac surgery from the Genome-Wide Association Study on Calcific Aortic Valve Stenosis in Quebec (QUEBEC-CAVS) study and patients with CAD, patients without CAD, and control participants from 6 genetic association studies: the UK Biobank, the European Prospective Investigation of Cancer (EPIC)-Norfolk, and Genetic Epidemiology Research on Aging (GERA) studies and 3 French cohorts. In addition, a family study included first-degree relatives of patients with CAVS. Data were collected from January 1993 to September 2018, and analysis was completed from September 2017 to September 2018. EXPOSURES: Case-control studies. MAIN OUTCOMES AND MEASURES: Presence of CAVS according to a weighted genetic risk score based on 3 common Lp(a)-raising variants and aortic valve microcalcification, defined as the mean tissue to background ratio of 1.25 or more, measured by fluorine 18-labeled sodium fluoride positron emission tomography/computed tomography. RESULTS: This study included 1009 individuals undergoing cardiac surgery and 1017 control participants in the QUEBEC-CAVS cohort; 3258 individuals with CAVS and CAD, 41 100 controls with CAD, 2069 individuals with CAVS without CAD, and 380 075 control participants without CAD in the UK Biobank, EPIC-Norfolk, and GERA studies and 3 French cohorts combined; and 33 first-de

Published
2019

30. Flt3L-Mediated Expansion of Plasmacytoid Dendritic Cells Suppresses HIV Infection in Humanized Mice

Author

Pham, Tram N.Q., primary, Meziane, Oussama, additional, Miah, Mohammad Alam, additional, Volodina, Olga, additional, Colas, Chloé, additional, Béland, Kathie, additional, Li, Yuanyi, additional, Dallaire, Frédéric, additional, Keler, Tibor, additional, Guimond, Jean V., additional, Lesage, Sylvie, additional, Cheong, Cheolho, additional, Haddad, Élie, additional, and Cohen, Éric A., additional

Published
2019
Full Text
View/download PDF

31. Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification

Author

Perrot, Nicolas, primary, Thériault, Sébastien, additional, Dina, Christian, additional, Chen, Hao Yu, additional, Boekholdt, S. Matthijs, additional, Rigade, Sidwell, additional, Després, Audrey-Anne, additional, Poulin, Anthony, additional, Capoulade, Romain, additional, Le Tourneau, Thierry, additional, Messika-Zeitoun, David, additional, Trottier, Mikaël, additional, Tessier, Michel, additional, Guimond, Jean, additional, Nadeau, Maxime, additional, Engert, James C., additional, Khaw, Kay-Tee, additional, Wareham, Nicholas J., additional, Dweck, Marc R., additional, Mathieu, Patrick, additional, Pibarot, Philippe, additional, Schott, Jean-Jacques, additional, Thanassoulis, George, additional, Clavel, Marie-Annick, additional, Bossé, Yohan, additional, and Arsenault, Benoit J., additional

Published
2019
Full Text
View/download PDF

32. Immune Responses to Human Induced Pluripotent Stem Cells and their Derived Myogenic Progenitors Are Mediated by Different Mechanisms in Humanized Mice

Author

Benabdallah, Basma, primary, Désaulniers-Langevin, Cynthia, additional, Goyer, Marie-Lyn, additional, Colas, Chloé, additional, Maltais, Chantale, additional, Li, Yuanyi, additional, Guimond, Jean V., additional, Tremblay, Jacques P, additional, Haddad, Elie, additional, and Beauséjour, Christian, additional

Published
2019
Full Text
View/download PDF

34. Conventional Dendritic Cells Impair Recovery after Myocardial Infarction

Author

Lee, Jun Seong, primary, Jeong, Se-Jin, additional, Kim, Sinai, additional, Chalifour, Lorraine, additional, Yun, Tae Jin, additional, Miah, Mohammad Alam, additional, Li, Bin, additional, Majdoubi, Abdelilah, additional, Sabourin, Antoine, additional, Keler, Tibor, additional, Guimond, Jean V., additional, Haddad, Elie, additional, Choi, Eui-Young, additional, Epelman, Slava, additional, Choi, Jae-Hoon, additional, Thibodeau, Jacques, additional, Oh, Goo Taeg, additional, and Cheong, Cheolho, additional

Published
2018
Full Text
View/download PDF

35. Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain

Author

Asahchop, Eugene L., primary, Meziane, Oussama, additional, Mamik, Manmeet K., additional, Chan, Wing F., additional, Branton, William G., additional, Resch, Lothar, additional, Gill, M. John, additional, Haddad, Elie, additional, Guimond, Jean V., additional, Wainberg, Mark A., additional, Baker, Glen B., additional, Cohen, Eric A., additional, and Power, Christopher, additional

Published
2017
Full Text
View/download PDF

36. Amplification of Adipogenic Commitment by VSTM2A

Author

Secco, Blandine, primary, Camiré, Étienne, additional, Brière, Marc-Antoine, additional, Caron, Alexandre, additional, Billong, Armande, additional, Gélinas, Yves, additional, Lemay, Anne-Marie, additional, Tharp, Kevin M., additional, Lee, Peter L., additional, Gobeil, Stéphane, additional, Guimond, Jean V., additional, Patey, Natacha, additional, Guertin, David A., additional, Stahl, Andreas, additional, Haddad, Élie, additional, Marsolais, David, additional, Bossé, Yohan, additional, Birsoy, Kivanc, additional, and Laplante, Mathieu, additional

Published
2017
Full Text
View/download PDF

37. Characterization of 3D PET systems for accurate quantification of myocardial blood flow

Author

Renaud, Jennifer M., Yip, Kathy, Guimond, Jean, Trottier, Mikaël, Pibarot, Philippe, Turcotte, Éric, Maguire, Conor, Lalonde, Lucille, Gulenchyn, Karen, Farncombe, Troy, Wisenberg, Gerald, Moody, Jonathan, Lee, Benjamin, Port, Steven C., Turkington, Timothy G, Beanlands, Robert S. B., DeKemp, Robert A., Renaud, Jennifer M., Yip, Kathy, Guimond, Jean, Trottier, Mikaël, Pibarot, Philippe, Turcotte, Éric, Maguire, Conor, Lalonde, Lucille, Gulenchyn, Karen, Farncombe, Troy, Wisenberg, Gerald, Moody, Jonathan, Lee, Benjamin, Port, Steven C., Turkington, Timothy G, Beanlands, Robert S. B., and DeKemp, Robert A.

Abstract

Three-dimensional (3D) mode imaging is the current standard for positron emission tomography-computed tomography (PET-CT) systems. Dynamic imaging for quantification of myocardial blood flow (MBF) with short-lived tracers, such as Rb-82- chloride (Rb-82), requires accuracy to be maintained over a wide range of isotope activities and scanner count-rates. We propose new performance standard measurements to characterize the dynamic range of PET systems for accurate quantitative imaging. Methods: 1100-3000 MBq of Rb-82 or N-13-ammonia was injected into the heart wall insert of an anthropomorphic torso phantom. A decaying isotope scan was performed over 5 half-lives on 9 different 3D PET-CT systems and 1 3D/twodimensional (2D) PET-only system. Dynamic images (28x15s) were reconstructed using iterative algorithms with all corrections enabled. Dynamic range was defined as the maximum activity in the myocardial wall with <10% bias, from which corresponding dead-time, count-rates and/or injected activity limits were established for each scanner. Scatter correction residual bias was estimated as the maximum cavity blood-tomyocardium activity ratio. Image quality was assessed via the coefficient of variation measuring non-uniformity of the left ventricle (LV) myocardium activity distribution. Results: Maximum recommended injected activity/body-weight, peak dead-time correction factor, count-rates and residual scatter bias for accurate cardiac MBF imaging were: 3-14 MBq/kg, 1.5-4.0, 22-64 Mcps singles and 4-14 Mcps prompt coincidence count-rates, and 2-10% on the investigated scanners. Non-uniformity of the myocardial activity distribution varied from 3-16%. Conclusion: Accurate dynamic imaging is possible on the 10 3D-PET systems if the maximum injected MBq/kg values are respected to limit peak dead-time losses during the bolus first-pass transit.

Published
2016

38. Clinical interpretation standards and quality assurance for the multicenter PET/CT trial rubidium-ARMI

Author

Renaud, Jennifer M., Trottier, Mikaël, Mylonas, Ilias, Guimond, Jean, McArdle, Brian, Pibarot, Philippe, Dowsley, Taylor, Yip, Kathy, Turcotte, Éric, Maguire, Conor, Lalonde, Lucille, Gulenchyn, Karen, Wisenberg, Gerald, Wells, R. Glenn, Ruddy, Terrence, Chow, Benjamin, Beanlands, Robert S. B., deKemp, Robert A., Renaud, Jennifer M., Trottier, Mikaël, Mylonas, Ilias, Guimond, Jean, McArdle, Brian, Pibarot, Philippe, Dowsley, Taylor, Yip, Kathy, Turcotte, Éric, Maguire, Conor, Lalonde, Lucille, Gulenchyn, Karen, Wisenberg, Gerald, Wells, R. Glenn, Ruddy, Terrence, Chow, Benjamin, Beanlands, Robert S. B., and deKemp, Robert A.

Abstract

Rubidium-ARMI (82Rb as an Alternative Radiopharmaceutical for Myocardial Imaging) is a multicenter trial to evaluate the accuracy, outcomes, and cost-effectiveness of low-dose 82Rb perfusion imaging using 3-dimensional (3D) PET/CT technology. Standardized imaging protocols are essential to ensure consistent interpretation. Methods: Cardiac phantom qualifying scans were obtained at 7 recruiting centers. Low-dose (10 MBq/kg) rest and pharmacologic stress 82Rb PET scans were obtained in 25 patients at each site. Summed stress scores, summed rest scores, and summed difference scores (SSS, SRS, and SDS [respectively] = SSS–SRS) were evaluated using 17-segment visual interpretation with a discretized color map. All scans were coread at the core lab (University of Ottawa Heart Institute) to assess agreement of scoring, clinical diagnosis, and image quality. Scoring differences greater than 3 underwent a third review to improve consensus. Scoring agreement was evaluated with intraclass correlation coefficient (ICC-r), concordance of clinical interpretation, and image quality using K coefficient and percentage agreement. Patient 99mTc and 201Tl SPECT scans (n = 25) from 2 centers were analyzed similarly for comparison to 82Rb. Results: Qualifying scores of SSS = 2, SDS = 2, were achieved uniformly at all imaging sites on 9 different 3D PET/CT scanners. Patient scores showed good agreement between core and recruiting sites: ICC-r = 0.92, 0.77 for SSS, SDS. Eighty-five and eighty-seven percent of SSS and SDS scores, respectively, had site–core differences of 3 or less. After consensus review, scoring agreement improved to ICC-r = 0.97, 0.96 for SSS, SDS (P < 0.05). The agreement of normal versus abnormal (SSS = 4) and nonischemic versus ischemic (SDS = 2) studies was excellent: ICC-r = 0.90 and 0.88. Overall interpretation showed excellent agreement, with a K = 0.94. Image quality was perceived differently by the site versus core reviewers (90% vs. 76% good or better; P < 0.05

Published
2016

39. Characterization of 3-Dimensional PET Systems for Accurate Quantification of Myocardial Blood Flow

Author

Renaud, Jennifer M., primary, Yip, Kathy, additional, Guimond, Jean, additional, Trottier, Mikaël, additional, Pibarot, Philippe, additional, Turcotte, Eric, additional, Maguire, Conor, additional, Lalonde, Lucille, additional, Gulenchyn, Karen, additional, Farncombe, Troy, additional, Wisenberg, Gerald, additional, Moody, Jonathan, additional, Lee, Benjamin, additional, Port, Steven C., additional, Turkington, Timothy G., additional, Beanlands, Rob S., additional, and deKemp, Robert A., additional

Published
2016
Full Text
View/download PDF

41. Clinical Utility of Amyloid PET Imaging in the Differential Diagnosis of Atypical Dementias and Its Impact on Caregivers

Author

Bensaïdane, Mohamed Reda, primary, Beauregard, Jean-Mathieu, additional, Poulin, Stéphane, additional, Buteau, François-Alexandre, additional, Guimond, Jean, additional, Bergeron, David, additional, Verret, Louis, additional, Fortin, Marie-Pierre, additional, Houde, Michèle, additional, Bouchard, Rémi W., additional, Soucy, Jean-Paul, additional, and Laforce, Robert, additional

Published
2016
Full Text
View/download PDF

42. MOLECULAR IMAGING OF THE HUMAN PULMONARY VASCULAR ENDOTHELIUM IN PULMONARY HYPERTENSION: THE PULMOBIND SAFETY AND PROOF OF PRINCIPLE TRIAL

Author

Dupuis, Jocelyn, primary, Harel, François, additional, Langleben, David, additional, Provencher, Steve, additional, Fournier, Alain, additional, Nguyen, Quang T., additional, Finnerty, Vincent, additional, Letourneau, Myriam, additional, Levac, Xavier, additional, Mansour, Asmaa, additional, Abikhzer, Gad, additional, and Guimond, Jean, additional

Published
2016
Full Text
View/download PDF

45. Clinical Impact of a Second FDG-PET in Atypical/Unclear Dementia Syndromes.

Author

Bergeron, David, Beauregard, Jean-Mathieu, Guimond, Jean, Fortin, Marie-Pierre, Houde, Michèle, Poulina, Stéphane, Verret, Louis, Bouchard, Rémi W., Laforce Jr., Robert, Poulin, Stéphane, and Laforce, Robert

Subjects
POSITRON emission tomography, DIAGNOSIS of dementia, TREATMENT of dementia, TREATMENT delay (Medicine), TERTIARY care
Abstract

Diagnosis of atypical/unclear dementia is often difficult and this delays treatment initiation. Several authors have shown that beyond standard dementia workup, 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) reduces the number of unclear diagnoses, leads to earlier treatment, and has a beneficial impact on families. However, it is not uncommon that the FDG-PET findings are equivocal in this setting. For those cases, a repeat FDG-PET may clarify the diagnosis and prevent treatment delay. We retrospectively assessed the clinical impact of a repeat FDG-PET in 59 patients with atypical/unclear dementia syndromes and inconclusive initial FDG-PET. Changes in primary diagnosis, diagnostic confidence, and management following the second FDG-PET were examined. Conducting a second FDG-PET reduced the number of unclear diagnoses from 80% to 34% , led to diagnostic change in 24% of cases, and treatment modification in 22% of patients. Overall, the clinical impact was higher when initial diagnostic confidence was low and the second FDG-PET repeated ≥12 months after the first one. In tertiary care memory clinic settings, when diagnostic incertitude persists despite extensive evaluation and an equivocal FDG-PET, repeating the FDG-PET 12 months later can greatly clarify the diagnosis and improve management. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

46. Specific alterations in NKG2D+T lymphocytes in relapsing-remitting and progressive multiple sclerosis patients

Author

Carmena Moratalla, Ana, Carpentier Solorio, Yves, Lemaître, Florent, Farzam-kia, Negar, Da Cal, Sandra, Guimond, Jean Victor, Haddad, Elie, Duquette, Pierre, Girard, J. Marc, Prat, Alexandre, Larochelle, Catherine, and Arbour, Nathalie

Abstract

•The expression and the phenotype of NKG2D-expressing T lymphocytes are altered in all types of MS: RRMS, SPMS, and PPMS patients compared with age- and sex-matched healthy controls.•The reduced frequency of NKG2D+ T cells in RRMS patients was caused by a decreased frequency of CD4-CD8- and CD8+ T lymphocytes, which largely express NKG2D.•NKG2D participates in the contacts between infiltrating CD8+ T lymphocytes and human astrocytes.

Published
2023
Full Text
View/download PDF

47. LETTERS.

Author

Stankiewicz, Rick, Montambault, André, and Guimond, Jean

Subjects
PLANETS, DWARF stars
Abstract

Several letters to the editor are presented including the challenge of seeing the five-planet alignment in Ontario, the discovery of white dwarf star Sirius in 1862 and one in response to an article regarding a review of Nikon D810A DSLR camera by Malcolm Park in the November/December 2015 issue.

Published
2016

48. Conventional Dendritic Cells Impair Recovery after Myocardial Infarction.

Author

Jun Seong Lee, Se-Jin Jeong, Sinai Kim, Chalifour, Lorraine, Tae Jin Yun, Miah, Mohammad Alam, Bin Li, Majdoubi, Abdelilah, Sabourin, Antoine, Keler, Tibor, Guimond, Jean V., Haddad, Elie, Eui-Young Choi, Epelman, Slava, Jae-Hoon Choi, Thibodeau, Jacques, Goo Taeg Oh, and Cheolho Cheong

Subjects
*MYOCARDIAL infarction, *DENDRITIC cells, *MACROPHAGES, *INTERLEUKIN-1, *CYTOKINES
Abstract

Ischemic myocardial injury results in sterile cardiac inflammation that leads to tissue repair, two processes controlled by mononuclear phagocytes. Despite global burden of cardiovascular diseases, we do not understand the functional contribution to pathogenesis of specific cardiac mononuclear phagocyte lineages, in particular dendritic cells. To address this limitation, we used detailed lineage tracing and genetic studies to identify bona fide murine and human CD103+ conventional dendritic cell (cDC)1s, CD11b+ cDC2s, and plasmacytoid DCs (pDCs) in the heart of normal mice and immunocompromised NSG mice reconstituted with human CD34+ cells, respectively. After myocardial infarction (MI), the specific depletion of cDCs, but not pDCs, improved cardiac function and prevented adverse cardiac remodeling. Our results showed that fractional shortening measured after MI was not influenced by the absence of pDCs. Interestingly, however, depletion of cDCs significantly improved reduction in fractional shortening. Moreover, fibrosis and cell areas were reduced in infarcted zones. This correlated with reduced numbers of cardiac macrophages, neutrophils, and T cells, indicating a blunted inflammatory response. Accordingly, mRNA levels of proinflammatory cytokines IL-1β and IFN-γ were reduced. Collectively, our results demonstrate the unequivocal pathological role of cDCs following MI. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

49. Generation of functional human T cell development in NOD/SCID/IL2rγ null humanized mice without using fetal tissue: Application as a model of HIV infection and persistence.

Author

Colas C, Volodina O, Béland K, Pham TNQ, Li Y, Dallaire F, Soulard C, Lemieux W, Colamartino ABL, Tremblay-Laganière C, Dicaire R, Guimond J, Vobecky S, Poirier N, Patey N, Cohen ÉA, and Haddad E

Subjects
Humans, Mice, Animals, Child, Mice, SCID, Mice, Inbred NOD, T-Lymphocytes, Thymus Gland, Disease Models, Animal, Mice, Knockout, HIV Infections
Abstract

Humanization of mice with functional T cells currently relies on co-implantation of hematopoietic stem cells from fetal liver and autologous fetal thymic tissue (so-called BLT mouse model). Here, we show that NOD/SCID/IL2rγ null mice humanized with cord blood- derived CD34 + cells and implanted with allogeneic pediatric thymic tissues excised during cardiac surgeries (CCST) represent an alternative to BLT mice. CCST mice displayed a strong immune reconstitution, with functional T cells originating from CD34 + progenitor cells. They were equally susceptible to mucosal or intraperitoneal HIV infection and had significantly higher HIV-specific T cell responses. Antiretroviral therapy (ART) robustly suppressed viremia and reduced the frequencies of cells carrying integrated HIV DNA. As in BLT mice, we observed a complete viral rebound following ART interruption, suggesting the presence of HIV reservoirs. In conclusion, CCST mice represent a practical alternative to BLT mice, broadening the use of humanized mice for research., Competing Interests: Conflict of interests The authors declare no competing interests., (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)

Published
2023
Full Text
View/download PDF

50. Stress Signal ULBP4, an NKG2D Ligand, Is Upregulated in Multiple Sclerosis and Shapes CD8 + T-Cell Behaviors.

Author

Carmena Moratalla A, Carpentier Solorio Y, Lemaitre F, Farzam-Kia N, Levert A, Zandee SEJ, Lahav B, Guimond JV, Haddad E, Girard M, Duquette P, Larochelle C, Prat A, and Arbour N

Subjects
Astrocytes, Autopsy, Brain pathology, Carrier Proteins cerebrospinal fluid, Cells, Cultured, Fetus, Histocompatibility Antigens Class I cerebrospinal fluid, Humans, Membrane Proteins cerebrospinal fluid, Multiple Sclerosis cerebrospinal fluid, Neurons, Stress, Physiological immunology, Up-Regulation, White Matter metabolism, Brain metabolism, CD8-Positive T-Lymphocytes, Carrier Proteins metabolism, Histocompatibility Antigens Class I metabolism, Membrane Proteins metabolism, Multiple Sclerosis immunology, Multiple Sclerosis metabolism, NK Cell Lectin-Like Receptor Subfamily K metabolism, Stress, Physiological physiology
Abstract

Background and Objectives: We posit the involvement of the natural killer group 2D (NKG2D) pathway in multiple sclerosis (MS) pathology via the presence of specific NKG2D ligands (NKG2DLs). We aim to evaluate the expression of NKG2DLs in the CNS and CSF of patients with MS and to identify cellular stressors inducing the expression of UL16-binding protein 4 (ULBP4), the only detectable NKG2DL. Finally, we evaluate the impact of ULBP4 on functions such as cytokine production and motility by CD8 + T lymphocytes, a subset largely expressing NKG2D, the cognate receptor., Methods: Human postmortem brain samples and CSF from patients with MS and controls were used to evaluate NKG2DL expression. In vitro assays using primary cultures of human astrocytes and neurons were performed to identify stressors inducing ULBP4 expression. Human CD8 + T lymphocytes from MS donors and age/sex-matched healthy controls were isolated to evaluate the functional impact of soluble ULBP4., Results: We detected mRNA coding for the 8 identified human NKG2DLs in brain samples from patients with MS and controls, but only ULBP4 protein expression was detectable by Western blot. ULBP4 levels were greater in patients with MS, particularly in active and chronic active lesions and normal-appearing white matter, compared with normal-appearing gray matter from MS donors and white and gray matter from controls. Soluble ULBP4 was also detected in CSF of patients with MS and controls, but a smaller shed/soluble form of 25 kDa was significantly elevated in CSF from female patients with MS compared with controls and male patients with MS. Our data indicate that soluble ULBP4 affects various functions of CD8 + T lymphocytes. First, it enhanced the production of the proinflammatory cytokines GM-CSF and interferon-γ (IFNγ). Second, it increased CD8 + T lymphocyte motility and favored a kinapse-like behavior when cultured in the presence of human astrocytes. CD8 + T lymphocytes from patients with MS were especially altered by the presence of soluble ULBP4 compared with healthy controls., Discussion: Our study provides new evidence for the involvement of NKG2D and its ligand ULBP4 in MS pathology. Our results point to ULBP4 as a viable target to specifically block 1 component of the NKG2D pathway without altering immune surveillance involving other NKG2DL., (Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.)

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results