240 results on '"Guimarães, S. E. F."'
Search Results
2. Genetic analysis of pig growth curves: a simulation study.
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Marques, D. B. D., Silva, F. F., Veroneze, R., Lopes, P. S., and Guimarães, S. E. F.
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GOMPERTZ functions (Mathematics) ,GENETIC correlations ,ARTIFICIAL selection of animals ,CURVES ,ANIMAL breeding ,SWINE breeding ,BODY weight - Abstract
Copyright of Archivos de Zootecnia is the property of Archivos de Zootecnia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
3. Antibody response between pigs of Piau and a commercial breed naturally infected with Porcine circovirus 2
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Bulos, L. H. S., Gonzaga, N. F., Souza, L. F. L., Assao, V. S., Leite, R. A. S., Rebouças, M. S., Scatamburlo, T. M., Guimarães, J. D., Guimarães, S. E. F., Lopes, P. S., Almeida, M. R. L., and Silva Júnior, A.
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0301 basic medicine ,Swine ,040301 veterinary sciences ,animal diseases ,Population ,serology ,Serology ,sorologia ,0403 veterinary science ,serum viral load ,03 medical and health sciences ,Animal science ,Immune system ,suíno ,Seroprevalence ,education ,lcsh:SF1-1100 ,Piau ,education.field_of_study ,viremia ,General Veterinary ,biology ,virus diseases ,04 agricultural and veterinary sciences ,biology.organism_classification ,Breed ,Porcine circovirus ,030104 developmental biology ,biology.protein ,lcsh:Animal culture ,Antibody ,Viral load - Abstract
Brazilian pig population is made up of several naturalized breeds; among them the Piau breed is known for its rusticity and large fat stores. The naturalized breeds, in comparison with commercial ones, may have an increased resistance to diseases circulating in their territory. Thus, this study aimed to verify if there are differences between the serologic profile against Porcine circovirus 2 (PCV2) of Piau pigs and that of a commercial breed from a farm naturally infected by PCV2. The serum viral load was measured by qPCR, and levels of anti-PCV2 antibodies were measured by ELISA. The results showed that the serum viral load was similar across all animals. However, Piau piglets showed higher levels of antibodies compared to commercial piglets (P= 0.05), while sows of the commercial breed showed higher levels than the Piau breed (P< 0.01). There was not a statistical difference between pigs of different production stages in the seroprevalence of PCV2 or the blood viral load. This work demonstrates that, with regard to a natural PCV2 infection, the Piau breed has a different humoral immune response compared to the response developed by the commercial pigs. The results support the importance of conservation of native breeds. RESUMO O rebanho de suínos brasileiro é constituído por diversas raças naturalizadas, entre elas a raça Piau, que é conhecida por sua rusticidade e pela grande deposição de toucinho. As raças naturalizadas, em comparação com as linhagens comerciais, podem ter uma maior resistência a doenças que circulam em seu território. Dessa forma, o presente estudo teve como objetivo verificar se existem diferenças no perfil sorológico contra o Porcine circovirus 2 (PVC2) entre suínos da raça Piau e de uma linhagem comercial de uma granja naturalmente infectada pelo PCV2. Foram realizadas mensurações da carga viral sérica por qPCR e dos níveis de anticorpos anti-PCV2 por meio da técnica de ELISA. Os resultados mostraram que a carga viral sérica se manteve homogênea em todos os animais e que os leitões da raça Piau apresentaram níveis de anticorpos superiores em comparação com os leitões da linhagem comercial (P=0,05), enquanto as porcas de linhagem comercial apresentaram níveis superiores aos da raça Piau (P
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- 2016
4. Effects of cottonseed oil and ferrous sulfate on the performance and expression of antioxidant enzymes in broilers
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Araujo, R S, primary, Oliveira, A C, additional, Sousa, F C B, additional, Dourado, L R B, additional, Guimarães, S E F, additional, Silva, W, additional, Biagiotti, D, additional, Bayão, G F V, additional, and Sousa, K R S, additional
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- 2019
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5. Disruption of bovine sperm functions in the presence of aplastic midpiece defect
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Díaz‐Miranda, E. A., primary, Maitan, P. P., additional, Machado, T. P., additional, Camilo, B. S., additional, Lima, D. A., additional, Okano, D. S., additional, Penitente‐Filho, J. M., additional, Machado‐Neves, M., additional, de Oliveira, L. L., additional, Guimarães, S. E. F., additional, da Costa, E. P., additional, and Guimarães, J. D., additional
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- 2019
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6. Effect of glycerin supplementation on the expression of antioxidant and mitochondrial genes in broilers
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Araújo, R. S., primary, Sousa, K. R. S., additional, Sousa, F. C. B., additional, Oliveira, A. C., additional, Dourado, L. R. B., additional, Guimarães, S. E. F., additional, Silva, W., additional, Biagiotti, D., additional, Bayão, G. F. V., additional, and Araujo, A. C., additional
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- 2019
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7. Disruption of bovine sperm functions in the presence of aplastic midpiece defect.
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Díaz‐Miranda, E. A., Maitan, P. P., Machado, T. P., Camilo, B. S., Lima, D. A., Okano, D. S., Penitente‐Filho, J. M., Machado‐Neves, M., Oliveira, L. L., Guimarães, S. E. F., Costa, E. P., and Guimarães, J. D.
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BILAYER lipid membranes ,SPERMATOZOA ,SEMEN analysis ,MITOCHONDRIAL membranes ,MEMBRANE potential ,MALE reproductive health - Abstract
Background: Bulls are of great importance in the productive chain and for this reason they should have a good semen quality. There is no doubt that sperm morphology is very important to bull fertility, although little is known about how exactly the abnormal morphologies may affect sperm functions. Objectives: To detail the morphological description of the aplastic midpiece defect (AMD), as well as to understand its consequences for male fertility based on membrane and acrosome status, mitochondrial membrane potential and DNA integrity parameters. Materials and methods: The bulls were divided into two groups: control, consisting of satisfactory potential breeders (n = 3); and AMD, consisting of unsatisfactory potential breeders with a high percentage of AMD (n = 3). Bulls were evaluated by the breeding soundness evaluation; five ejaculates were collected from each animal and analyzed by flow cytometry. Results: Spermatozoa from AMD group exhibited lower sperm motility and vigor (p < 0.05). In addition, it also exhibited lower mitochondrial membrane potential (p < 0.05), a higher percentage of spermatozoa with DNA fragmentation (p < 0.05), lower acrosome and plasma membrane integrity (p < 0.05), and higher lipid bilayer sperm membrane disorganization (p < 0.05) in comparison with control bulls. Discussion: These findings may be due to oxidative stress and a reduction of the energy production capacity in addition to an alteration in the structural composition of the sperm cell. Moreover, semen with a high percentage of AMD may also be undergoing apoptosis. Conclusion: Bulls with a high percentage of AMD in their semen are not suitable for reproduction. Furthermore, it suggests there is a putative genetic basis for this sperm defect. [ABSTRACT FROM AUTHOR]
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- 2020
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8. Genotype by feed interaction for feed efficiency and growth performance traits in pigs1
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Godinho, R M, primary, Bastiaansen, J W M, additional, Sevillano, C A, additional, Silva, F F, additional, Guimarães, S E F, additional, and Bergsma, R, additional
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- 2018
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9. Genetic correlations between feed efficiency traits, and growth performance and carcass traits in purebred and crossbred pigs
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Godinho, R M, primary, Bergsma, R, additional, Silva, F F, additional, Sevillano, C A, additional, Knol, E F, additional, Lopes, M S, additional, Lopes, P S, additional, Bastiaansen, J W M, additional, and Guimarães, S E F, additional
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- 2018
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10. Genetic parameters for semen quality and quantity traits in five pig lines1
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Marques, D. B. D., primary, Lopes, M. S., additional, Broekhuijse, M. L. W. J., additional, Guimarães, S. E. F., additional, Knol, E. F., additional, Bastiaansen, J. W. M., additional, Silva, F. F., additional, and Lopes, P. S., additional
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- 2017
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11. Multiple-trait genomewide mapping and gene network analysis for scrotal circumference growth curves in Brahman cattle1
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Soares, A. C. C., primary, Guimarães, S. E. F., additional, Kelly, M. J., additional, Fortes, M. R. S., additional, e Silva, F. F., additional, Verardo, L. L., additional, Mota, R., additional, and Moore, S., additional
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- 2017
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12. Regularized quantile regression for SNP marker estimation of pig growth curves
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Barroso, L. M. A., primary, Nascimento, M., additional, Nascimento, A. C. C., additional, Silva, F. F., additional, Serão, N. V. L., additional, Cruz, C. D., additional, Resende, M. D. V., additional, Silva, F. L., additional, Azevedo, C. F., additional, Lopes, P. S., additional, and Guimarães, S. E. F., additional
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- 2017
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13. TRIENNIAL GROWTH AND DEVELOPMENT SYMPOSIUM: Dedifferentiated fat cells: Potential and perspectives for their use in clinical and animal science purpose1
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Duarte, M. S., primary, Bueno, R., additional, Silva, W., additional, Campos, C. F., additional, Gionbelli, M. P., additional, Guimarães, S. E. F., additional, Silva, F. F., additional, Lopes, P. S., additional, Hausman, G. J., additional, and Dodson, M. V., additional
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- 2017
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14. Dietary L-arginine supplementation increased mammary gland vascularity of lactating sows.
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Holanda, D. M., Marcolla, C. S., Guimarães, S. E. F., Neves, M. M., Hausman, G. J., Duarte, M. S., Abreu, M. L. T., and Saraiva, A.
- Abstract
The present study aimed to evaluate the mechanisms modulated by dietary arginine supplementation to sows during lactation regarding antioxidant capacity and vascularization of mammary glands. At 109 days of gestation, animals were transferred to individual farrowing crates equipped with manual feeders and automatic drinker bowls. Environmental temperature and humidity inside the farrowing rooms were registered every 15 min. At farrowing, sows were assigned in a completely randomized design to a control diet (CON) or the CON diet supplemented with 1.0% L-arginine (ARG). A total of three gilts and two sows were fed the CON diet, whereas three gilts and three sows were fed ARG diets. Sows were fed a fixed amount of 6.0 kg/day, subdivided equally in four delivery times (0700, 1000, 1300 and 1600 h) for 21 days. At weaning, sows were slaughtered and mammary tissue samples and blood from the pudendal vein were collected. Data were analyzed considering each sow as an experimental unit. Differences were considered at P <0.05. L-arginine fed sows presented lower messenger RNA (mRNA) expression for prolactin receptor (P =0.002), angiopoietin1 (P =0.03) and receptor tyrosine kinase (P =0.01); higher mRNA expression for prostaglandin synthase 1 (P =0.0 1); a trend of decrease for glucocorticoid receptor (P =0.06) and IGF receptor 1 (P =0.07); and a trend (P =0.05) for an increased glutathione peroxidase mRNA expression. The angiopoietin2:angiopoietin1 mRNA ratio tended to increase (P =0.07) in ARG fed sows. L-arginine fed sows had greater (P =0.04) volumetric proportion of blood vessels and a trend of enhance (P =0.07) in the number of blood vessels per mm
2 . These findings show that 1.0% ARG supplementation to sows activates proliferative mechanisms, may improve mammary tissues' angiogenesis and tended to increase mRNA expression of genes that encode antioxidant enzymes in mammary gland of sows. [ABSTRACT FROM AUTHOR]- Published
- 2019
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15. After genome-wide association studies: Gene networks elucidating candidate genes divergences for number of teats across two pig populations1
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Verardo, L. L., primary, Lopes, M. S., additional, Wijga, S., additional, Madsen, O., additional, Silva, F. F., additional, Groenen, M. A. M., additional, Knol, E. F., additional, Lopes, P. S., additional, and Guimarães, S. E. F., additional
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- 2016
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16. Accuracy of genome-enabled prediction exploring purebred and crossbred pig populations1
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Veroneze, R., primary, Lopes, M. S., additional, Hidalgo, A. M., additional, Guimarães, S. E. F., additional, Silva, F. F., additional, Harlizius, B., additional, Lopes, P. S., additional, Knol, E. F., additional, M. van Arendonk, J. A., additional, and Bastiaansen, J. W. M., additional
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- 2015
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17. The use of ultrasonography in the reproductive evaluation of boars.
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Pinho, R. O., Camilo, B. S., Lima, D. M. A., Villadiego, F. A. C., Vergara, J. C. M., Shiomi, H. H., Cardoso, R. E., Lopes, P. S., Guimarães, S. E. F., and Guimarães, J. D.
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BOARS ,SEMEN analysis ,EPIDIDYMIS ,ARTIFICIAL selection of animals ,ULTRASONIC imaging ,REPRODUCTION - Abstract
Contents: The objective was to study the use of ultrasound as a complementary test in the breeding soundness evaluation in male pigs and study the pattern of echogenicity of the testicular parenchyma in boars of different racial groups. Twenty‐six adult boars from four different racial groups were used, 10 from the Piau breed (group 1), four from the commercial and finishing group (group 2), six Pietrain breed (group 3) and six from the Duroc breed (group 4). All animals were evaluated for breeding soundness evaluation and the ultrasound examination of the testicles. The groups of animals that were evaluated showed no difference in the main semen parameters that were evaluated, except for the sperm volume, concentration of the ejaculated sperm and the supravital staining; the lowest figures were for the animals from the Piau breed (group 1). In relation to the testicular biometrics, Duroc animals (group 4) had a greater scrotal width compared to the other groups. But when we assessed the intensity of pixels of the testicles, there was a difference between groups. The groups 2 (finishing animals), 3 (Pietrain) and 4 had no difference between themselves. Group 3 had greater pixel intensity in relation to group 1. Of the 26 animals studied, five showed an abnormality during ultrasound evaluation, like hydrocele, hyperechoic mass in the testicular parenchyma, cyst in the head of the epididymis and the presence of fluid in the head and tail of the epididymis. The various animal groups studied did not differ in the principal reproductive parameters evaluated, showing that despite the great variability of reproductive traits between breeds and within the same breed, the breeding soundness evaluation, the more complete it is, is essential for the selection of breeders and the ultrasonography of the reproductive system becomes an important addition in this examination. [ABSTRACT FROM AUTHOR]
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- 2018
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18. Technical note: Mammary gland ultrasonography to evaluate mammary parenchymal composition in prepubertal heifers.
- Author
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Albino, R. L., Guimarães, S. E. F., Daniels, K. M., Fontes, M. M. S., Machado, A. F., dos Santos, G. B., and Marcondes, M. I.
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MAMMARY glands , *ULTRASONIC imaging , *HEIFERS , *PROTEINS , *BODY weight - Abstract
Bovine mammary gland development studies are often terminal or involve invasive biopsy procedures. Therefore, noninvasive means of assessing mammary development should be considered as alternative methods in live animals. The objective was to test if mammary ultrasonography can be used as a noninvasive way to estimate mammary parenchyma (PAR) composition in prepubertal dairy heifers with different average daily body weight gains. In the 84 d preceding, the ultrasound exam heifers were maintained in 1 of 3 treatment groups. Individual heifers were fed a high gain (1 kg/d; n = 6), low gain (0.5 kg/d, n = 6), or maintenance (n = 6) treatment diet. To achieve desired body weight gains, heifers were fed differing amounts of the same silage-based diet. Mammary glands of 18 crossbred heifers Holstein:Gyr underwent a single mammary ultrasound exam immediately before heifer slaughter, which took place when heifers weighed 142.0 ± 8.0 kg and were 200 d old. The 4 mammary glands of each heifer were evaluated using a real-time B-mode ultrasound machine equipped with a 6.5-MHz microconvex transducer. Digital images (8-bit) of glands were obtained and PAR was identified within gland. Average pixel values per unit of PAR area were determined for each gland and analyzed at the level of heifer. Pixel results were interpreted on the basis that lower average pixel values reflect PAR with relatively high amounts of protein as opposed to fat. To help validate that the pixel value within PAR is associated with composition of PAR, pixel findings were compared with histological [number of adipocytes in PAR (Nad) and epithelial area in PAR (Ep)] and biochemical [percent crude protein in PAR (%CP), percent ether extract in PAR (%EE), PAR weight (WPAR), and mammary fat pad weight (WFAT)] composition of PAR in these same heifers. Within PAR, %EE and WFAT were positively correlated with pixel values, whereas %CP, Ep, and Nad were negatively correlated. Parenchyma weight did not correlate with pixel values. Regression analyses (fixed effect log-pixel value; random effect treatment) were used to estimate Nad, Ep, %CP, %EE, WPAR, and WFAT. Sensitivity analysis of regression equations revealed that accuracy of tested equations ranged from 0.77 to 0.93 and precision ranged from 0.56 to 0.82. Concordance correlation coefficients of the equations ranged from 0.41 to 0.76. In conclusion, ultrasonography of PAR can accurately measure and predict PAR composition in prepubertal dairy heifers growing at various rates of gain. [ABSTRACT FROM AUTHOR]
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- 2017
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19. Resequencing of Brazilian locally adapted cattle breeds revealed variants in candidate genes and transcription factors for meat fatty acid profile.
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Vieira JIG, Braga LG, Chud TCS, Ferreira PH, Guimarães SEF, Martins MF, do Carmo Panetto JC, Machado MA, Silva DBDS, Bonafé CM, Magalhães AFB, da Silva MVGB, and Verardo LL
- Abstract
The beef cattle industry has experienced a shift driven by a market demand for healthier meat, cost efficiency and environmental sustainability in recent years. Consequently, there has been a growing focus on the fatty acids content and functions of meat in cattle breeding programmes. Besides, a deeper understanding of the biological mechanisms influencing the expression of different phenotypes related to fatty acid profiles is crucial. In this study, we aimed to identify Single-Nucleotide Variants (SNV) and Insertion/Deletion (InDels) DNA variants in candidate genes related to fatty acid profiles described in genomic, transcriptomic and proteomic studies conducted in beef cattle breeds. Utilizing whole-genome re-sequencing data from Brazilian locally adapted bovine breeds, namely Caracu and Pantaneiro, we identified SNVs and InDels associated with 23,947 genes. From these, we identified 318 candidate genes related to fatty acid profiles that contain variants. Subsequently, we select only genes with SNVs and InDels in their promoter, 5' UTR and coding region. Through the gene-biological process network, approximately 19 genes were highlighted. Furthermore, considering the studied trait and a literature review, we selected the main transcription factors (TF). Functional analysis via gene-TF network allowed us to identify the 30 most likely candidate genes for meat fatty acid profile in cattle. LIPE, MFSD2A and SREBF1 genes were highlighted in networks due to their biological importance. Further dissection of these genes revealed 15 new variants found in promoter regions of Caracu and Pantaneiro sequences. The gene networks facilitated a better functional understanding of genes and TF, enabling the identification of variants potentially related to the expression of candidate genes for meat fatty acid profiles in cattle., (© 2024 Wiley‐VCH GmbH. Published by John Wiley & Sons Ltd.)
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- 2024
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20. Maternal overnutrition enhances mRNA expression of adipogenic markers and collagen deposition in skeletal muscle of beef cattle fetuses1
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Duarte, M. S., primary, Gionbelli, M. P., additional, Paulino, P. V. R., additional, Serão, N. V. L., additional, Nascimento, C. S., additional, Botelho, M. E., additional, Martins, T. S., additional, Filho, S. C. V., additional, Dodson, M. V., additional, Guimarães, S. E. F., additional, and Du, M., additional
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- 2014
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21. Sire evaluation for total number born in pigs using a genomic reaction norms approach1
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Silva, F. F., primary, Mulder, H. A., additional, Knol, E. F., additional, Lopes, M. S., additional, Guimarães, S. E. F., additional, Lopes, P. S., additional, Mathur, P. K., additional, Viana, J. M. S., additional, and Bastiaansen, J. W. M., additional
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- 2014
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22. Review: Animal model and the current understanding of molecule dynamics of adipogenesis.
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Campos, C. F., Duarte, M. S., Guimarães, S. E. F., Verardo, L. L., Wei, S., Du, M., Jiang, Z., Bergen, W. G., Hausman, G. J., Fernyhough-Culver, M., Albrecht, E., and Dodson, M. V.
- Abstract
Among several potential animal models that can be used for adipogenic studies, Wagyu cattle is the one that presents unique molecular mechanisms underlying the deposit of substantial amounts of intramuscular fat. As such, this review is focused on current knowledge of such mechanisms related to adipose tissue deposition using Wagyu cattle as model. So abundant is the lipid accumulation in the skeletal muscles of these animals that in many cases, the muscle cross-sectional area appears more white (adipose tissue) than red (muscle fibers). This enhanced marbling accumulation is morphologically similar to that seen in numerous skeletal muscle dysfunctions, disease states and myopathies; this might indicate cross-similar mechanisms between such dysfunctions and fat deposition in Wagyu breed. Animal models can be used not only for a better understanding of fat deposition in livestock, but also as models to an increased comprehension on molecular mechanisms behind human conditions. This revision underlies some of the complex molecular processes of fat deposition in animals. [ABSTRACT FROM PUBLISHER]
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- 2016
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23. Expressão gênica em ovócitos suínos de diferentes classificações morfológicas.
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Oliveira, F. A. S. A. M., Paixão, D. M., Amorim, L. S., Pereira, D. B., Guimarães, S. E. F., and Guimarães, J. D.
- Abstract
Copyright of Arquivo Brasileiro de Medicina Veterinaria e Zootecnia is the property of Universidade Federal de Minas Gerais, Escola de Veterinaria and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2016
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24. Rumen-protected methionine modulates body temperature and reduces the incidence of heat stress temperatures during the hottest hours of the day of grazing heat-stressed Bos indicus beef cows.
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Izquierdo VS, da Silva Menezes B, Lopes MG, Malaguez EG, Lopes F, Pereira FM, Brauner CC, Moriel P, Corrêa MN, and Schmitt E
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- Animals, Cattle physiology, Female, Hot Temperature adverse effects, Time Factors, Heat Stress Disorders veterinary, Heat Stress Disorders prevention & control, Body Temperature Regulation drug effects, Humidity, Heat-Shock Response drug effects, Fertilization drug effects, Animal Feed, Diet veterinary, Insemination, Artificial veterinary, Insemination, Artificial methods, Methionine administration & dosage, Methionine pharmacology, Rumen metabolism, Dietary Supplements, Body Temperature drug effects
- Abstract
This study evaluated the effects of supplementation of rumen-protected methionine (RPM) on body thermoregulation and conception rate of Nelore cows exposed to high temperature-humidity index (THI). On -31 days before the artificial insemination protocol, 562 lactating, multiparous cows were assigned to receive (MG) or not (CG) RPM supplementation (3 g/cow mixed into 100 g of mineral supplement). Both groups remained in tropical pastures and received supplementation for 77 days. A subset of cows (n = 142) remained with an intravaginal thermometer collecting intravaginal temperature (IT). The respective minimum, average, and maximum environmental THI were 72.8, 78.0, and 83.3. Effects of treatment × hour of the day were detected (P < 0.0001) for IT. From 1330 to 1730 h and 1830 to 1900 h, IT was higher (P < 0.05) for CG versus MG cows when exposed to moderate and high THI. The supplementation with RPM did not affect conception rate (CG = 64.4% vs. MG = 58.2%; P > 0.05). In conclusion, 3 g of RPM supplementation lowered internal body temperature and possibly altered critical THI threshold in Nelore cows with no impact on reproduction., (© 2024 Japanese Society of Animal Science.)
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- 2024
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25. Editorial: Omics applied to livestock genetics: volume II.
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Lima Verardo, Lucas, Carolino, Nuno, Ramos Duarte, Marcela, Rodrigues Almeida, Emily Alves, Dallago, Gabriel, and Braga Magalhães, Ana Fabrícia
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ANIMAL genetics ,LOCUS (Genetics) ,GENE expression ,NUCLEIC acids ,GENETIC variation ,CATTLE breeds ,ANIMAL breeding - Abstract
This editorial discusses the use of omics approaches in livestock genetics, specifically focusing on studies that have used large-scale datasets to understand genetic traits in various livestock animals. The studies mentioned in the article examine genes associated with growth, meat production, and skin development in pigs, ducks, rabbits, and donkeys. The article emphasizes the importance of these studies in advancing our understanding of farm animal genetics and improving breeding strategies. The authors also highlight the need for more multiomic analyses and integration of omics technologies with phenomics in breeding programs. Overall, these studies contribute to a better understanding of the genetic architecture of livestock species and have implications for the livestock industry. [Extracted from the article]
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- 2024
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26. Proteomic changes of the bovine blood plasma in response to heat stress in a tropically adapted cattle breed.
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Reolon, Henrique Goncalves, Abduch, Natalya Gardezani, Claudia de Freitas, Ana, de Oliveira Silva, Rafael Medeiros, de Oliveira Fragomeni, Breno, Lourenco, Daniela, Baldi, Fernando, Paro de Paz, Claudia Cristina, and Stafuzza, Nedenia Bonvino
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LIQUID chromatography-mass spectrometry ,INDUCTIVELY coupled plasma mass spectrometry ,CATTLE breeds ,CATTLE ,ESTRUS ,PROTEOMICS ,BLOOD plasma ,PHYSIOLOGICAL effects of heat - Abstract
Background: Identifying molecular mechanisms responsible for the response to heat stress is essential to increase production, reproduction, health, and welfare. This study aimed to identify early biological responses and potential biomarkers involved in the response to heat stress and animal's recovery in tropically adapted beef cattle through proteomic analysis of blood plasma. Methods: Blood samples were collected from 14 Caracu males during the heat stress peak (HSP) and 16 h after it (heat stress recovery--HSR) assessed based on wet bulb globe temperature index and rectal temperature. Proteome was investigated by liquid chromatography-tandem mass spectrometry from plasma samples, and the differentially regulated proteins were evaluated by functional enrichment analysis using DAVID tool. The protein-protein interaction network was evaluated by STRING tool. Results: A total of 1,550 proteins were detected in both time points, of which 84 and 65 were downregulated and upregulated during HSR, respectively. Among the differentially regulated proteins with the highest absolute log-fold change values, those encoded by the GABBR1, EPHA2, DUSP5, MUC2, DGCR8, MAP2K7, ADRA1A, CXADR, TOPBP1, and NEB genes were highlighted as potential biomarkers because of their roles in response to heat stress. The functional enrichment analysis revealed that 65 Gene Ontology terms and 34 pathways were significant (P < 0.05). We highlighted those that could be associated with the response to heat stress, such as those related to the immune system, complement system, hemostasis, calcium, ECM-receptor interaction, and PI3K-Akt and MAPK signaling pathways. In addition, the protein-protein interaction network analysis revealed several complement and coagulation proteins and acute-phase proteins as important nodes based on their centrality and edges. Conclusion: Identifying differentially regulated proteins and their relationship, as well as their roles in key pathways contribute to improve the knowledge of the mechanisms behind the response to heat stress in naturally adapted cattle breeds. In addition, proteins highlighted herein are potential biomarkers involved in the early response and recovery from heat stress in tropically adapted beef cattle. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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27. Large-Scale Phenotyping of Livestock Welfare in Commercial Production Systems: A New Frontier in Animal Breeding.
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Brito, Luiz F., Oliveira, Hinayah R., McConn, Betty R., Schinckel, Allan P., Arrazola, Aitor, Marchant-Forde, Jeremy N., and Johnson, Jay S.
- Subjects
ANIMAL breeding ,ANIMAL breeds ,ANIMAL welfare ,MOLECULAR biology ,LIVESTOCK breeding ,LIVESTOCK breeds ,LIVESTOCK - Abstract
Genomic breeding programs have been paramount in improving the rates of genetic progress of productive efficiency traits in livestock. Such improvement has been accompanied by the intensification of production systems, use of a wider range of precision technologies in routine management practices, and high-throughput phenotyping. Simultaneously, a greater public awareness of animal welfare has influenced livestock producers to place more emphasis on welfare relative to production traits. Therefore, management practices and breeding technologies in livestock have been developed in recent years to enhance animal welfare. In particular, genomic selection can be used to improve livestock social behavior, resilience to disease and other stress factors, and ease habituation to production system changes. The main requirements for including novel behavioral and welfare traits in genomic breeding schemes are: (1) to identify traits that represent the biological mechanisms of the industry breeding goals; (2) the availability of individual phenotypic records measured on a large number of animals (ideally with genomic information); (3) the derived traits are heritable, biologically meaningful, repeatable, and (ideally) not highly correlated with other traits already included in the selection indexes; and (4) genomic information is available for a large number of individuals (or genetically close individuals) with phenotypic records. In this review, we (1) describe a potential route for development of novel welfare indicator traits (using ideal phenotypes) for both genetic and genomic selection schemes; (2) summarize key indicator variables of livestock behavior and welfare, including a detailed assessment of thermal stress in livestock; (3) describe the primary statistical and bioinformatic methods available for large-scale data analyses of animal welfare; and (4) identify major advancements, challenges, and opportunities to generate high-throughput and large-scale datasets to enable genetic and genomic selection for improved welfare in livestock. A wide variety of novel welfare indicator traits can be derived from information captured by modern technology such as sensors, automatic feeding systems, milking robots, activity monitors, video cameras, and indirect biomarkers at the cellular and physiological levels. The development of novel traits coupled with genomic selection schemes for improved welfare in livestock can be feasible and optimized based on recently developed (or developing) technologies. Efficient implementation of genetic and genomic selection for improved animal welfare also requires the integration of a multitude of scientific fields such as cell and molecular biology, neuroscience, immunology, stress physiology, computer science, engineering, quantitative genomics, and bioinformatics. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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28. Genomic prediction based on a joint reference population for the Xinjiang Brown cattle.
- Author
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Menghua Zhang, Lei Xu, Haibo Lu, Hanpeng Luo, Jinghang Zhou, Dan Wang, Xiaoxue Zhang, Xixia Huang, and Yachun Wang
- Subjects
CATTLE breeds ,HOLSTEIN-Friesian cattle ,CATTLE ,ESTIMATION bias ,CATTLE breeding ,FORECASTING - Abstract
Introduction: Xinjiang Brown cattle constitute the largest breed of cattle in Xinjiang. Therefore, it is crucial to establish a genomic evaluation system, especially for those with low levels of breed improvement. Methods: This study aimed to establish a cross breed joint reference population by analyzing the genetic structure of 485 Xinjiang Brown cattle and 2,633 Chinese Holstein cattle (Illumina GeneSeek GGP bovine 150 K chip). The Bayes method single-step genome-wide best linear unbiased prediction was used to conduct a genomic evaluation of the joint reference population for the milk traits of Xinjiang Brown cattle. The reference population of Chinese Holstein cattle was randomly divided into groups to construct the joint reference population. By comparing the prediction accuracy, estimation bias, and inflation coefficient of the validation population, the optimal number of joint reference populations was determined. Results and Discussion: The results indicated a distinct genetic structure difference between the two breeds of adult cows, and both breeds should be consideredwhen constructing multi-breed joint reference and validation populations. The reliability range of genome prediction of milk traits in the joint reference population was 0.142-0.465. Initially, it was determined that the inclusion of 600 and 900 Chinese Holstein cattle in the joint reference population positively impacted the genomic prediction of Xinjiang Brown cattle to certain extent. It was feasible to incorporate the Chinese Holstein into Xinjiang Brown cattle population to forma joint reference population for multi-breed genomic evaluation. However, for different Xinjiang Brown cattle populations, a fixed number of Chinese Holstein cattle cannot be directly added duringmulti-breed genomic selection. Pre-evaluation analysis based on the genetic structure, kinship, and other factors of the current population is required to ensure the authenticity and reliability of genomic predictions and improve estimation accuracy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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29. Relative Expression of Toll-like Receptors, Cytokines and Acute Phase Protein by Real-Time PCR in Milk Somatic Cells of Subclinical Mastitis Affected Cattle.
- Author
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Singathia, Rajesh, Sharma, Deepak Kumar, Gaurav, Abhishek, Sain, Arpita, and Rathore, Karishma
- Subjects
ACUTE phase proteins ,SOMATIC cells ,BOVINE mastitis ,TOLL-like receptors ,MILK proteins ,CYTOKINES ,IMMUNOREGULATION - Abstract
Background: Subclinical mastitis is one of the most important diseases of economic importance affecting dairy animals worldwide. The present study was planned to evaluate the level of expression of toll-like receptors, cytokines and acute phase protein in milk somatic cells during subclinical mastitis of cattle. Methods: The milk samples of subclinical mastitis-positive and healthy cattle were collected. After that, extraction of total RNA was done from milk somatic cells followed by cDNA synthesis by the process of reverse transcription. Following that qPCR was carried out and relative transcript levels were determined. Result: In the present study, a relative up-regulated expression was found in TLR-2, IL-1β, IL-10 and Hp and down-regulation was found in TLR-4, TNF-α, IFN-γ and IL-6 in the milk of cattle with subclinical mastitis as compared to healthy ones. Monitoring of cytokines entangled in the modulation of immune responses during the infection is useful in deciding cytokine markers that could be employed as a forecasting tool in the early diagnosis of subclinical mastitis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
30. Physiological and Genetic Aspects of some Fitness Traits Performance in Pigs.
- Author
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Anh Thi NGUYEN and NAGY, István
- Published
- 2024
31. آنالیز بیوانفورماتیکی ژنهای کاندید مؤثر بر چند قلوزایی و تولید شیر در بز.
- Author
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بهرام افضلی تلخک, محسن قلی زاده, سید حسن حافظیان, and سید مهدی اسماعیل
- Abstract
Background and Objectives: Milk production and reproductive traits are important economic traits in goat. The different approaches including candidate gene mapping and genome-wide association studies (GWAS) are now implemented in goats in an attempt to identify the molecular mechanisms affecting these economically important traits. The gene ontology (GO) analysis gives a controlled vocabulary for describing attributes of genes and gene products. Kyoto Encyclopedia of Genes and Genomes (KEGG) provides the mythology for the careful examination of gene functions in respect of networks of genes and molecules. Gene network analysis can also identify paths and processes shared by candidate genes. The purpose of the present study was to bioinformatics analysis (GO, path enrichment, and network analysis of the effects of protein-protein interaction) of genes effective in litter size and milk production in goat. Materials and Methods: Candidate genes associated with studied traits were retrieved from literature review, review of candidate gene studies, GWAS and NCBI database. GO analysis and enrichment analysis of the signaling pathways of KEGG were performed using online database of G: Profiler. The String database was used to infer the network of protein-protein interactions (PPI) and the selection of performance module. Cytoscape software was used to draw the resultant networks of protein-protein interactions. Finally, cytoHubba was used to identify Hub genes. Results: GO analysis for litter size showed that, for molecular function the candidates genes enriched in signaling receptor binding, signaling receptor active activity, hormone activity, protein binding and transforming growth factor beta receptor activity. The effect of the transforming growth factor β (TGF-β) family on fertility and reproduction, embryonic development, organogenesis, and uterine growth and function is remarkable in a wide range of organisms. In mammals, even early stages of reproductive development, including male and female germline specification, are controlled by TGF-βrelated proteins. Hormone binding play an important role in fertility and reproduction. Sex hormone-binding globulin (SHBG), specifically bound to the biologically active androgens and estrogens that are key regulators of the reproductive organs as well as other sex-differentiated tissues such as muscle, adipose tissue, and bone. KEGG analysis also identified some signaling pathways including ،PI3K-Akt signaling pathway, TGF-beta signaling pathway and ovarian steroidogenesis which are significantly associated with litter size. GO analysis for 33 candidate genes related to milk production traits identified only one GO category for biological process namely linoleic acid metabolic process. Conclusion: In this study, we identified several significant biological and signaling pathways that can be used to better understand the biological processes associated with litter size and milk production in goats. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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32. Study on Multiple Linear Regression and Principal Component Analysis for Prediction of Lifetime Performance of Kankrej Cattle.
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Sawami, Radha Rani, Kumar, Virendra, and Pannu, Urmila
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PRINCIPAL components analysis ,MULTIPLE regression analysis ,CATTLE ,MILK yield ,GOAT milk - Abstract
The present investigation was conducted on 274 Kankrej cattle maintained at Livestock Research Station, Kodamdesar, Bikaner, calved between 2012 to 2022 with the objectives to study principal component analysis (PCA) and multiple linear regression analysis (MLRA) for prediction of lifetime performance of Kankrej cattle. Six early lactation traits (First lactation length- FLL, First lactation dry period-FDP, First lactation 305 days' milk yield- F305DMY, Second lactation length- SLL, Second lactation dry period- SDP, and Second lactation 305 days' milk yield- S305DMY) were used to analyze the lifetime milk yield upto 5
th and 7th lactations. The MLR analysis revealed that the model containing F305DMY, SLL and S305DMY for upto 5th lactations' lifetime milk yield, and model containing F305DMY, FDP and SLL for upto 7th lactations' lifetime milk yield having R² = 68.3% and 68.5%, respectively, were found to be optimal models. PCA revealed that the first 2 principal components (FLL, F305DMY) explained more than 78% of the total variation for LTMY5 and more than 81% variation for LTMY7. In this study F305DMY was found most important early trait in prediction of lifetime production of Kankrej cattle on the basis of PCA and MLR analysis, out of which PCA was found to be better. Significant finding of this study may be helpful in developing selection methodology for Kankrej cattle after validation in a large population. [ABSTRACT FROM AUTHOR]- Published
- 2024
33. The role of BTG1 and BTG2 genes and their effects on insulin in poultry.
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Kulikov, Egor Igorevich, Malakheeva, Lidia Ivanovna, and Komarchev, Alexey Sergeevich
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- 2024
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34. Development and evaluation of a novel single nucleotide polymorphism panel for North American bison.
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Stroupe, Sam and Derr, James N.
- Subjects
AMERICAN bison ,WHOLE genome sequencing ,GENE frequency ,IDENTIFICATION of animals ,ANIMAL populations ,SINGLE nucleotide polymorphisms - Abstract
Genome‐wide single nucleotide polymorphism (SNP) genotyping platforms have become increasingly popular in characterizing livestock and wildlife populations, replacing traditional methods such as microsatellite fragment analysis. Herein, we report the development and evaluation of a novel bison SNP panel for population management and conservation. Initially, 2474 autosomal SNPs were selected from existing bison whole‐genome sequences and variable sites among bison on the GGSP bovine 50K Chip, based on minor allele frequency, data completeness, and chromosome location. Additionally, 20 mitochondrial SNPs were chosen to identify known mitochondrial haplotypes in bison according to previous research. The SNPs were further evaluated using genotyping‐by‐sequencing with 190 bison, representing the historical lineages that survived the major population crash of the late 1800s. Variants with high potential for genotyping error were filtered out, and the remaining SNPs were placed on a custom Illumina™ array. The final panel consisting of 798 autosomal and 13 mitochondrial SNPs was used to establish baseline genetic parameters, compare populations, and assign mitochondrial haplotypes in 995 bison across ten populations. These SNPs were also found to be highly informative for individual animal identification and parentage assignment. This SNP panel provides a powerful new method to establish a baseline for estimating genetic health of bison populations and a new tool for bison managers to make informed management decisions based on genetic information specific to their populations. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
35. Genetic Parameters of Semen Traits and Their Correlations with Conformation Traits in Chinese Holstein Bulls.
- Author
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Wang, Xiao, Yang, Jian, Xue, Jie, Zhang, Miao, Zhang, Fan, Wang, Kun, Li, Yanqin, Zhang, Yuanpei, Wu, Xiaoping, Wang, Feng, Zhao, Xiuxin, Ni, Junqing, Ma, Yabin, Li, Rongling, Wang, Lingling, Su, Guosheng, Gao, Yundong, and Li, Jianbin
- Subjects
GENETIC correlations ,SEMEN ,SEMEN analysis ,BULLS ,PRODUCTION quantity ,DAIRY cattle - Abstract
The elite bull plays an extremely important role in the genetic progression of the dairy cow population. The previous results indicated the potential positive relationship of large scrotal circumference (SC) with improved semen volume, concentration, and motility. In order to improve bull's semen quantity and quality by selection, it is necessary to estimate the genetic parameters of semen traits and their correlations with other conformation traits such as SC that could be used for an indirect selection. In this study, the genetic parameters of seven semen traits (n = 66,260) and nine conformation traits (n = 3,642) of Holstein bulls (n = 453) were estimated by using the bivariate repeatability animal model with the average information-restricted maximum likelihood (AI-REML) approach. The results showed that the estimated heritabilities of semen traits ranged from 0.06 (total number of motile sperm, TNMS) to 0.37 (percentage of abnormal sperm, PAS) and conformation traits ranged from 0.23 (pin width, PW) to 0.69 (hip height, HH). The highest genetic correlations were found between semen volume per ejaculation (SVPE), semen concentration per ejaculation (SCPE), total number of sperm (TNS), and TNMS traits that were 0.97, 0.98, 1.00, and 0.99, respectively. Phenotypic correlations between SC and SVPE, SCPE, TNS, and TNMS were 0.35, 0.35, 0.48, and 0.42, respectively. In summary, the moderate or high heritability of semen traits indicates that genetic improvement of semen quality by selection is feasible, where SC could be a useful trait for indirect selection or as correlated information to improve semen quantity and production in the practical bull breeding programs. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
36. Influence of variance component estimates on genomic predictions for growth and reproductive-related traits in Nellore cattle.
- Author
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Cardona-Cifuentes D, Neira JDR, Albuquerque LG, Espigolan R, Gonzalez-Herrera LG, Amorim ST, López-Correa RD, Aguilar I, and Baldi F
- Abstract
This study aimed to estimate variance components (VCs) for growth and reproductive traits in Nellore cattle using two relationship matrices (pedigree relationship A matrix and pedigree plus genomic relationship H matrix), and records collected before and after genomic selection (GS) implementation. The study also evaluated how genomic breeding values (GEBV) are affected by variance components and discarding old records. The analysed traits were weight at 120 days (W120), weight and scrotal circumference at 450 days (W450 and SC450, respectively). Three datasets were used to estimate VCs, including all phenotypic information (All) or records for animals born before or after GS implementation (Before or After datasets, respectively). Both relationship matrices were considered for VC estimation, the A matrix was used in all three datasets and VC from each combination were named as A_Before, A_After, and A_All). The H was used in two datasets: H_All and H_After. Different VCs were used for GEBV prediction through ssGBLUP. This step used two possible Datasets, using all available phenotypic data (Dataset 1) or just records collected since GS implementation (Dataset 2). Validation was conducted using accuracy, bias and dispersion according to the LR method and prediction accuracy from corrected phenotypes. The heritability of all traits increased from A_Before to A_After, while estimates for A_All were intermediary. In the previous order, the estimates were 0.16, 0.17, and 0.15 for W120; 0.31, 0.39, and 0.35 for W450; 0.35, 0.47, and 0.41 for SC. For W450 and SC, using the H matrix reduced the heritability (0.33 and 0.32 for W450; 0.41 and 0.38 for SC for H_After and H_All, respectively). For W120, Dataset1 and VCs from A_After showed the highest accuracy for direct and maternal GEBV (0.953 and 0.868). For W450, Dataset 1 and VC from H_After allowed the highest accuracy (0.854) but use Dataset 2 and same VC source yield similar value (0.846). For SC, Dataset 2 with VC from H_After showed the highest accuracy (0.925). To use Dataset 2 does not cause important changes in bias or dispersion with respect to Dataset 1. The VC and genetic parameters changed for W120, W450, and SC450, using records before or after the GS implementation. For W450 and SC450, genetic variance and heritability estimates increased with the use of GS. For W120, genomic predictions were more accurate using A for VC estimation. Accuracy gains were observed for W450 and SC450 using H in VC estimation and/or discarding records before GS. It is possible to discard phenotypic records before GS implementation without generating bias or dispersion in the GEBV of young candidates., (© 2024 Wiley‐VCH GmbH. Published by John Wiley & Sons Ltd.)
- Published
- 2024
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37. Trends and challenges in liquid-preserved boar semen production: From boar to product.
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Schulze M, Henneberg S, Riedel A, and Hensel B
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- Animals, Male, Swine, Breeding methods, Insemination, Artificial veterinary, Cryopreservation veterinary, Cryopreservation methods, Semen Analysis veterinary, Sus scrofa physiology, Semen Preservation veterinary, Semen Preservation methods, Semen physiology
- Abstract
Boar semen production plays a pivotal role in modern swine breeding programmes, influencing the genetic progress and overall efficiency of the pork industry. This review explores the current challenges and emerging trends in liquid-preserved boar semen production, addressing key issues that impact the quality and quantity of boar semen. Advances in new reproductive technologies, boar selection, housing, semen processing, storage and transport, and the need for sustainable practices including the use of artificial intelligence are discussed to provide a comprehensive overview of the field., (© 2024 Wiley‐VCH GmbH. Published by John Wiley & Sons Ltd.)
- Published
- 2024
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38. Genomic analyses of nitrogen utilization efficiency, its indicator trait blood urea nitrogen and the relationship to classical growth performance and feed efficiency traits in a Landrace × Piétrain crossbred population.
- Author
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Schmid M, Weishaar R, Seifert J, Camarinha-Silva A, Rodehutscord M, and Bennewitz J
- Subjects
- Animals, Swine genetics, Swine growth & development, Breeding, Phenotype, Male, Polymorphism, Single Nucleotide, Female, Genomics, Genotype, Blood Urea Nitrogen, Nitrogen metabolism, Animal Feed analysis
- Abstract
Improving the nutrient efficiency in pork production is required to reduce the resource competition between human food and animal feed regarding diet components edible for humans and to minimize emissions relevant to climate or the environment. Thereby, protein utilization efficiency and its equivalent nitrogen utilization efficiency (NUE) play a major role. Breeding for more nitrogen (N) efficient pigs bears a promising strategy to improve such traits, however, directly phenotyping NUE based on N balance data is neither cost-efficient nor straightforward and not applicable for routine evaluations. Blood urea nitrogen (BUN) levels in the pig are suitable to predict the NUE and, therefore, might be an indicator trait for NUE because BUN is a relatively easy-to-measure trait. This study investigated the suitability of NUE as a selection trait in future breeding programs. The relationships to classical growth performance and feed efficiency traits were analysed as well as the relationship to BUN to infer the role of BUN as an indicator trait to improve NUE via breeding. The analyzes were based on a Landrace F1 cross population consisting of 502 individuals who descended from 20 Piétrain sires. All animals were genotyped for 48,525 SNPs. They were phenotyped in two different fattening phases, i.e., FP1 and FP2, during the experiment. Uni- and bivariate analyses were run to estimate variance components and to determine the genetic correlation between different traits or between the same trait measured at different time points. Moderate heritabilities were estimated for all traits, whereby the heritability for NUE was h
2 = 0.293 in FP1 and h2 = 0.163 in FP2 and BUN had the by far highest heritability (h2 = 0.415 in FP1 and h2 = 0.460 in FP2). The significant genetic correlation between NUE and BUN showed the potential of BUN to be considered an indicator trait for NUE. This was particularly pronounced when NUE was measured in FP1 (genetic correlations r g = - 0.631 and r g = - 0.688 between NUE and BUN measured in FP1 and FP2, respectively). The genetic correlations of NUE and BUN with important production traits suggest selecting pigs with high growth rates and low BUN levels to breed more efficient pigs in future breeding programs., (© 2024 The Authors. Journal of Animal Breeding and Genetics published by John Wiley & Sons Ltd.)- Published
- 2024
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39. l-Arginine supplementation for pregnant and lactating sows may improve the performance of piglets: A systematic review.
- Author
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Cruz FL, Mendes MFDSA, Silva TO, Filho MBG, and de Abreu MLT
- Abstract
The objective was to conduct a systematic review to clarify the effects of l-arginine supplementation in pregnant and lactating sows on plasma hormone levels, milk production and composition, the body condition of sows and piglet performance. In April 2023, an online search and a systematic search were performed in the following databases: Embase, Scopus, SciELO, Web of Science, PubMed and Science Direct. The combinations of keywords used were sow and arginine and lactation; sow and arginine and lactating; sow and arginine and gestation; sow and arginine and gestating; sow and arginine and pregnancy; sow and arginine and reproduction; piglet and arginine; and sow and arginine and mammary gland. In total, 21 scientific articles with original data were selected according to preestablished criteria. Among the 21 articles, seven (33%) reported measurements of some plasma hormones, and among these, six reported an increase in the levels of at least one hormone, namely, estradiol, insulin-like growth factor 1 (IGF-1), insulin, follicle stimulating hormone, growth hormone or prolactin, with l-arginine supplementation. The parameters of milk were evaluated in 11 studies (52%), one reported an increase in protein content, and one reported an increase in IGF-1 content in milk with supplementation of this amino acid. Of the 14 studies that evaluated the performance parameters of piglets, only four reported improvements in some parameters of piglets from sows that received supplementation. Dietary supplementation of arginine for sows in the final third of gestation and/or lactation may alter the plasma levels of some hormones, which may reflect in greater development of the mammary gland tissue and, consequently, promote benefits on the performance of piglets. However, more studies are needed to evaluate the real impact of this amino acid supplementation on the physiology of the sows, in general, and the performance of suckling piglets., (© 2024 Wiley‐VCH GmbH. Published by John Wiley & Sons Ltd.)
- Published
- 2024
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40. Proteomics is advancing the understanding of stallion sperm biology.
- Author
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Peña FJ, Martín-Cano FE, Becerro-Rey L, Ortega-Ferrusola C, Gaitskell-Phillips G, da Silva-Álvarez E, and Gil MC
- Subjects
- Animals, Horses, Male, Proteome metabolism, Proteome analysis, Biomarkers metabolism, Spermatozoa metabolism, Proteomics methods
- Abstract
The mammalian ejaculate is very well suited to proteomics studies. As such, research concerning sperm proteomics is offering a huge amount of new information on the biology of spermatozoa. Among domestic animals, horses represent a species of special interest, in which reproductive technologies and a sizeable market of genetic material have grown exponentially in the last decade. Studies using proteomic approaches have been conducted in recent years, showing that proteomics is a potent tool to dig into the biology of the stallion spermatozoa. The aim of this review is to present an overview of the research conducted, and how these studies have improved our knowledge of stallion sperm biology. The main outcomes of the research conducted so far have been an improved knowledge of metabolism, and its importance in sperm functions, the impact of different technologies on the sperm proteome, and the identification of potential biomarkers. Moreover, proteomics of seminal plasma and phosphoproteomics are identified as areas of major interest., (© 2024 The Author(s). PROTEOMICS published by Wiley‐VCH GmbH.)
- Published
- 2024
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41. POR TRÁS DA LEPTINA: UMA REVISÃO DE LITERATURA.
- Author
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Willemann de Castro, Thalita Etiene, de Paula Garcia, Valentina, and Seraphim Gasques, Luciano
- Abstract
Copyright of Arquivos de Ciências da Saúde da UNIPAR is the property of Associacao Paranaense de Ensino e Cultura and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
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42. Cottonseed oil alleviates ischemic stroke injury by inhibiting ferroptosis.
- Author
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Sun, Miao, Liu, Min, Li, Qingxiao, Zhang, Xiaoying, Liu, Siyuan, Yang, Huikai, Yang, Le, Tian, Jiahe, Mi, Weidong, and Ma, Yulong
- Published
- 2023
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- View/download PDF
43. Calving date as a potential predictor for the probability of approval in the first breeding soundness evaluation of Nellore bulls.
- Author
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Diaz‐Miranda, Edgar Andres, Penitente‐Filho, Jurandy Mauro, Gomez‐Leon, Victor Enrique, Lopez, Camilo Jose Ramirez, Villadiego, Faider Alberto Castaño, Okano, Denise Silva, Neto, Tamires Miranda, Guimarães, Simone Facioni, Siqueira, Jeanne Broch, and Guimarães, José Domingos
- Subjects
COW-calf system ,BULLS ,BEEF industry ,CATTLE fertility ,AKAIKE information criterion ,PEARSON correlation (Statistics) - Abstract
Beef production systems primarily use natural service (NS) for breeding. However, a significant number of bulls used for NS are subfertile, limiting the profitability of the cow‐calf operations. Therefore, producers should select bulls based on breeding soundness evolutions (BSE) to ensure higher pregnancy rates. Several factors can affect the bull ability to pass a BSE. We hypothesize that calving date would be a factor that affects the bull probability of approval at the first BSE. For this purpose, a multivariate logistic regression in a dataset of 14,737 BSEs from young Nellore bulls was used. Correlations between calving date, biometrics, and semen traits were evaluated using Pearson's correlation coefficient. Our results demonstrated that the calving date affected the probability of approval at the first BSE (p <.05). Indeed, the variable that added more information to our model was the calving date, far more than the age group of the bulls according to Akaike's information criterion. Hence, bulls born on day 0 of the calving season have 1.26 more chances to be approved at the first BSE than bulls born 21 days later. This result highlights the importance of getting the dams of future bulls pregnant as soon as possible in the breeding season. In addition, the calving season should be no longer than 47 days to achieve 80% BSE approval in 20–22 months old Nellore bulls. The strongest correlation was with SC, which decreased as the calving date increased. Therefore, the calving date may be used as a predictor of the outcome of the first BSE in young bulls. In that way, the calving date can help seedstock producers to maximize efficiency in making crucial management decisions during the breeding and calving season including nutrition, reproductive, and culling. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
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44. Composition of Mastitis Causing Microorganisms and Cytokines in Healthy Cow's Milk: A Pilot Study.
- Author
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Junga, Anna, Pilmane, Māra, Šerstņova, Ksenija, Lohova, Elizabeta, Melderis, Ivars, Gontar, Łukasz, Kochański, Maksymilian, Drutowska, Andżelika, Maróti, Gergely, and Prieto-Simón, Beatriz
- Subjects
TRANSFORMING growth factors ,ESCHERICHIA coli ,MASTITIS ,COWS ,CYTOKINES - Abstract
The aim of this study was to examine clinically healthy cow's udder milk microbiota and presence of cytokines in different seasons. Milk samples taken from the cows were checked for the presence of Gram-positive and Gram-negative bacteria, and the somatic cell count was detected. Immunohistochemistry methods were performed to detect interleukin (IL) -2, IL-4, IL-8, IL-10, IL-12, IL-17a, β-defensin-3, transforming growth factor (TGF)-β1, interferon-γ and nuclear factor (NF)-κB presence in the milk. S. agalactiae, S. uberis, S. aureus, E. coli, and Klebsiella, Enterobacter, Citrobacter spp. were found in healthy cow's milk. In the first round, the highest prevalence was observed for S. aureus. In the second round, the highest mean levels were observed for S. uberis, then followed S. aureus. IL-4, IL-17a and TGF-β1 demonstrated the highest expression in the milk samples. NF-κB had the lowest expression among all factors. The presence of a rich bacterial microbiome (mostly S.aureus, S.uberis) in the milk of healthy animals, as well as changing bacterial species between in spring and autumn seasons occur as a result of both the immune state of the animal and many external factors, which consequently affects the amount of expressed cytokines. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
45. Applying an association weight matrix in weighted genomic prediction of boar taint compounds.
- Author
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Botelho ME, Lopes MS, Mathur PK, Knol EF, Guimarães SEF, Marques DBD, Lopes PS, Silva FF, and Veroneze R
- Subjects
- Animals, Genome, Genome-Wide Association Study veterinary, Genomics, Male, Phenotype, Skatole, Swine genetics
- Abstract
Biological information regarding markers and gene association may be used to attribute different weights for single nucleotide polymorphism (SNP) in genome-wide selection. Therefore, we aimed to evaluate the predictive ability and the bias of genomic prediction using models that allow SNP weighting in the genomic relationship matrix (G) building, with and without incorporating biological information to obtain the weights. Firstly, we performed a genome-wide association studies (GWAS) in data set containing single- (SL) or a multi-line (ML) pig population for androstenone, skatole and indole levels. Secondly, 1%, 2%, 5%, 10%, 30% and 50% of the markers explaining the highest proportions of the genetic variance for each trait were selected to build gene networks through the association weight matrix (AWM) approach. The number of edges in the network was computed and used to derive weights for G (AWM-WssGBLUP). The single-step GBLUP (ssGBLUP) and weighted ssGBLUP (WssGBLUP) were used as standard scenarios. All scenarios presented predictive abilities different from zero; however, the great overlap in their confidences interval suggests no differences among scenarios. Most of scenarios of based on AWM provide overestimations for skatole in both SL and ML populations. On the other hand, the skatole and indole prediction were no biased in the ssGBLUP (S1) in both SL and ML populations. Most of scenarios based on AWM provide no biased predictions for indole in both SL and ML populations. In summary, using biological information through AWM matrix and gene networks to derive weights for genomic prediction resulted in no increase in predictive ability for boar taint compounds. In addition, this approach increased the number of analyses steps. Thus, we can conclude that ssGBLUP is most appropriate for the analysis of boar taint compounds in comparison with the weighted strategies used in the present work., (© 2020 Wiley-VCH GmbH.)
- Published
- 2021
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46. Comparative assessment of growth performance, heat resistance and carcass traits in four poultry genotypes reared in hot-humid tropical environment.
- Author
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Hemanth M, Venugopal S, Devaraj C, Shashank CG, Ponnuvel P, Mandal PK, and Sejian V
- Abstract
This study investigated the impact of heat stress on growth and carcass traits in four poultry genotypes-Giriraja, Country chicken, Naked Neck and Kadaknath reared in a hot and humid tropical environment. Birds from all genotypes had ad libitum access to feed and water while being challenged with consistently high environmental temperatures in the experimental shed. Daily diurnal meteorological data were recorded inside and outside the shed. The study specifically examined growth variables and carcass characteristics. Significant differences (p < 0.01) were observed in body weight and average daily gain at various intervals. Notably, feed intake showed significant differences (p < 0.01) across weeks, indicating interactions between genotypes and time intervals. The feed conversion ratio (FCR) varied significantly (p < 0.01), with the highest FCR recorded in the Kadaknath breed. Livability percentages were similar across groups, except for Giriraja, which had significantly lower livability (p < 0.01). Carcass traits, including dressing, wings, feathers and giblet percentages, showed significant differences among genotypes (p < 0.01). Hepatic mRNA expression of growth-related genes revealed numerical variations, with Naked Neck displaying the highest (p < 0.05) fold change in IGF-1 expression compared to other genotypes. The study recognized in the Naked Neck genotype to possess higher resilience in maintaining homoeostasis and uncompromised growth under heat stress, providing valuable insights for sustainable poultry farming in challenging environmental conditions., (© 2024 Wiley‐VCH GmbH. Published by John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
47. A review of the role of transcription factors in regulating adipogenesis and lipogenesis in beef cattle.
- Author
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Abebe BK, Wang H, Li A, and Zan L
- Subjects
- Cattle genetics, Animals, Transcription Factors genetics, Transcription Factors metabolism, Epigenesis, Genetic, Adipose Tissue metabolism, Muscle, Skeletal metabolism, Lipogenesis genetics, Adipogenesis genetics
- Abstract
In the past few decades, genomic selection and other refined strategies have been used to increase the growth rate and lean meat production of beef cattle. Nevertheless, the fast growth rates of cattle breeds are often accompanied by a reduction in intramuscular fat (IMF) deposition, impairing meat quality. Transcription factors play vital roles in regulating adipogenesis and lipogenesis in beef cattle. Meanwhile, understanding the role of transcription factors in regulating adipogenesis and lipogenesis in beef cattle has gained significant attention to increase IMF deposition and meat quality. Therefore, the aim of this paper was to provide a comprehensive summary and valuable insight into the complex role of transcription factors in adipogenesis and lipogenesis in beef cattle. This review summarizes the contemporary studies in transcription factors in adipogenesis and lipogenesis, genome-wide analysis of transcription factors, epigenetic regulation of transcription factors, nutritional regulation of transcription factors, metabolic signalling pathways, functional genomics methods, transcriptomic profiling of adipose tissues, transcription factors and meat quality and comparative genomics with other livestock species. In conclusion, transcription factors play a crucial role in promoting adipocyte development and fatty acid biosynthesis in beef cattle. They control adipose tissue formation and metabolism, thereby improving meat quality and maintaining metabolic balance. Understanding the processes by which these transcription factors regulate adipose tissue deposition and lipid metabolism will simplify the development of marbling or IMF composition in beef cattle., (© 2023 Wiley‐VCH GmbH. Published by John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
48. Intra-uterine programming of future fertility.
- Author
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Chavatte-Palmer P, Couturier-Tarrade A, and Rousseau-Ralliard D
- Subjects
- Female, Animals, Pregnancy, Placenta physiology, Epigenesis, Genetic, Animals, Domestic, Uterus physiology, Humans, Fertility physiology, Fetal Development
- Abstract
The developmental origins of health and disease (DOHaD) shows that a relationship exists between parental environment at large, foeto-placental development and the risk for the offspring to develop non-transmittable disease(s) in adulthood. This concept has been validated in both humans and livestock. In mammals, after fertilization and time spent free in the maternal reproductive tract, the embryo develops a placenta that, in close relationship with maternal endometrium, is the organ responsible for exchanges between dam and foetus. Any modification of the maternal environment can lead to adaptive mechanisms affecting placental morphology, blood flow, foetal-maternal exchanges (transporters) and/or endocrine function, ultimately modifying placental efficiency. Among deleterious environments, undernutrition, protein restriction, overnutrition, micronutrient deficiencies and food contaminants can be outlined. When placental adaptive capacities become insufficient, foetal growth and organ formation is no longer optimal, including foetal gonadal formation and maturation, which can affect subsequent offspring fertility. Since epigenetic mechanisms have been shown to be key to foetal programming, epigenetic modifications of the gametes may also occur, leading to inter-generational effects. After briefly describing normal gonadal development in domestic species and inter-species differences, this review highlights the current knowledge on intra-uterine programming of offspring fertility with a focus on domestic animals and underlines the importance to assess transgenerational effects on offspring fertility at a time when new breeding systems are developed to face the current climate changes., (© 2023 The Authors. Reproduction in Domestic Animals published by Wiley‐VCH GmbH.)
- Published
- 2024
- Full Text
- View/download PDF
49. High percentage of midpiece defects in Brangus bull sperm with no reduction in sperm kinematics.
- Author
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Maggi G, Silveira D, Vieira MB, da Silva IGM, Barros-Cordeiro KB, Severo NC, Báo SN, and Mondadori RG
- Subjects
- Male, Animals, Cattle, Biomechanical Phenomena, Sperm Midpiece, Sperm Motility, Acrosome, Cryopreservation veterinary, Semen Preservation veterinary, Semen Analysis veterinary, Spermatozoa abnormalities, Spermatozoa physiology
- Abstract
The study investigated midpiece defects in sperm from a 5-year-old Brangus bull with a high rate of semen batch rejection, due to morphologically abnormal sperm, with no reduction in sperm kinematics. A comprehensive evaluation was conducted over a 16-month period, involving 28 ejaculates. Notably, despite the high proportion of midpiece defects (average 37.73%, from 3% to 58%), the study revealed stable sperm production, with no discernible differences in the kinematic data before and after cryopreservation. Electron microscopy identified discontinuities in the mitochondrial sheath, characteristic of midpiece aplasia (MPA). The anomalies were attributed to be of genetic origin, as other predisposing factors were absent. Additionally, the electron microscopy unveiled plasma membrane defects, vacuoles and chromatin decondensation, consistent with previous findings linking acrosome abnormalities with midpiece defects. The findings underscored the necessity of conducting thorough laboratory evaluations before releasing cryopreserved semen for commercialization. Despite substantial morphological alterations, the initial semen evaluation data indicated acceptable levels of sperm kinematics, emphasizing the resilience of sperm production to severe morphological changes. This case report serves as a contribution to the understanding of midpiece defects in bull sperm, emphasizing the need for meticulous evaluation and quality control in semen processing and commercialization., (© 2024 Wiley‐VCH GmbH. Published by John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
50. Microsatellite imputation using SNP data for parentage verification in four Italian sheep breeds.
- Author
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Ablondi M, Stocco G, Cortellari M, Carta A, Summer A, Negro A, Grande S, Crepaldi P, Cipolat-Gotet C, and Biffani S
- Subjects
- Humans, Sheep genetics, Animals, Cattle genetics, Genotype, Microsatellite Repeats genetics, Italy, Polymorphism, Single Nucleotide, Genome
- Abstract
Microsatellite markers (MS) have been widely used for parentage verification in most of the livestock species over the past decades mainly due to their high polymorphic information content. In the genomic era, the spread of genotype information as single-nucleotide polymorphism (SNP) has raised the question to effectively use SNPs also for parentage testing. Despite the clear advantages of SNP panels in terms of cost, accuracy, and automation, the transition from MS to SNP markers for parentage verification is still very slow and, so far, only routinely applied in cattle. A major difficulty during this transition period is the need of SNP data for parents and offspring, which in most cases is not yet feasible due to the genotyping cost. To overcome the unavailability of same genotyping platform during the transition period, in this study we aimed to assess the feasibility of a MS imputation pipeline from SNPs in four native sheep dairy breeds: Comisana (N = 331), Massese (N = 210), Delle Langhe (N = 59) and Sarda (N = 1003). Those sheep were genotyped for 11 MS and with the Ovine SNP50 Bead Chip. Prior to imputation, a quality control (QC) was performed, and SNPs located within a window of 2 Mb from each MS were selected. The core of the developed pipeline was made up of three steps: (a) storing of both MS and SNP data in a Variant Call Format file, (b) masking MS information in a random sample of individuals (10%), (c) imputing masked MS based on non-missing individuals (90%) using an imputation program. The feasability of the proposed methodology was assessed also among different training - testing split ratio, population size, number of flanking SNPs as well as within and among breeds. The accuracy of the MS imputation was assessed based on the genotype concordance as well as at parentage verification level in a subset of animals in which assigned parents' MS were available. A total of 8 MS passed the QC, and 505 SNPs were located within the ±2 Mb window from each MS, with an average of 63 SNPs per MS. The results were encouraging since when excluding the worst imputed MS (OARAE129), and regardless on the analyses performed (within and across breeds) for all breeds, we achieved an overall concordance rate over 94%. In addition, on average, the imputed offspring MS resulted in equivalent parentage outcome in 94% of the cases when compared to verification using original MS, highlighting both the feasibility and the eventual practical advantage of using this imputation pipeline., (© 2023 The Authors. Journal of Animal Breeding and Genetics published by John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
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