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35 results on '"Guha, Gautam"'

9. Retinal nerve fiber layer thinning found in amyotrophic lateral sclerosis - Correlation with disease duration and severity

Author

Mohanty, Bijendra, Misra, Amar, Kumar, Sanjay, Guha, Gautam, Bhattacharya, Annesh, Ngullie, Pideno, Manna, Akash, Nanda, Tapashya, and Mukherjee, Joydeep

Subjects
Amyotrophic lateral sclerosis -- Development and progression -- Care and treatment, Optical tomography -- Methods, Health
Abstract

Byline: Bijendra. Mohanty, Amar. Misra, Sanjay. Kumar, Gautam. Guha, Annesh. Bhattacharya, Pideno. Ngullie, Akash. Manna, Tapashya. Nanda, Joydeep. Mukherjee Purpose: The retinal involvement of amyotrophic lateral sclerosis (ALS) is a [...]

Published
2023

11. P300 Wave Alterations and Cognitive Impairment in Cerebellum Lesions

Author

Nanda, Sourav, Lapeña Motilva, José, Kumar Misra, Amar, Guha, Gautam, Ghosh, Sinjan, Manna, Akash, Roy, Soumit, Benito León, Julián, Nanda, Sourav, Lapeña Motilva, José, Kumar Misra, Amar, Guha, Gautam, Ghosh, Sinjan, Manna, Akash, Roy, Soumit, and Benito León, Julián

Abstract

AbstractPatients with cognitive deficits have a prolonged latency and reduced amplitude of the P300 wave. However, no study has correlated P300 wave alterations with the cognitive performance of patients with cerebellar lesions. We aimed to determine if the cognitive status of these patients was associated with P300 wave alterations. We recruited 30 patients with cerebellar lesions from the wards of the N.R.S. Medical College, Kolkata, in West Bengal (India). The Kolkata Cognitive Screening Battery tasks and the Frontal Assessment Battery (FAB) were used to assess the cognitive status and the International Cooperative Ataxia Rating Scale (ICARS) for cerebellar signs. We compared the results with the normative data of the Indian population. Patients had P300 wave alterations with a significant increase in latency and a non-significant trend in amplitude. In a multivariate model, P300 wave latency was positively associated with the ICARS kinetic subscale (p = 0.005) and age (p = 0.009), regardless of sex and years of education. In the model that included cognitive variables, P300 wave latency was negatively associated with performance in phonemic fluency (p = 0.035) and construction (p = 0.009). Furthermore, P300 wave amplitude was positively associated with the FAB total score (p < 0.001). In closing, patients with cerebellar lesions had an increase in latency and a decrease in the amplitude of the P300 wave. These P300 wave alterations were also associated with worse cognitive performance and some of the subscales of the ICARS, reinforcing that the cerebellum has motor, cognitive, and affective functions., National Institutes of Health (EEUU), European Commission, Ministerio de Ecnomía y Competitividad, Fundación Española para la Ciencia y la Tecnología, Depto. de Medicina, Fac. de Medicina, TRUE, pub, APC financiada por la UCM

Published
2023

14. A Study on Clinical Profile of Hemifacial Spasm in India and the Therapeutic Response to Botulinum Toxin Type A Injection as well as Pre and Postinjection Quality of Life

Author

Misra, Amar Kumar, primary, Mukherjee, Joydeep, additional, Kumar, Sanjay, additional, Guha, Gautam, additional, Mohanty, Bijendra, additional, Ngullie, Pideno S, additional, Manna, Akash, additional, Nanda, Tapashya, additional, Das, Amit Kumar, additional, and Tiwari, Kamlesh, additional

Published
2022
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20. Hepatitis B virus-induced CD4 lymphocytopenia: A rare cause of progressive multifocal leukoencephalopathy.

Author

Misra, Amar Kumar, Kumar, Sanjay, Agasti, Niraja, Guha, Gautam, Ghosh, Saikat, Mohanty, Bijendra, Ngullie, Pideno S., and Mukherjee, Joydeep

Subjects
JOHN Cunningham virus, PROGRESSIVE multifocal leukoencephalopathy, HEPATITIS B, HIV infections, CHRONIC active hepatitis, CHRONIC hepatitis B
Abstract

Progressive multifocal leukoencephalopathy (PML) is a rare subacute-onset fatal demyelinating disease of the central nervous system caused by the John Cunningham (JC) virus. It usually occurs in impaired cell-mediated immunity settings such as lymphoproliferative disorders, chronic infective or granulomatous conditions on immunosuppressive medications, and human immunodeficiency virus infection. It also appears very rarely with idiopathic CD4 lymphocytopenia. We present a case of PML with visual field defect, progressive motor impairment, behavioral alteration, and dementia. Magnetic resonance imaging had features of asymmetric non-enhancing hyperintense subcortical white matter lesions in the background of chronic active hepatitis B infection. To the best of our knowledge, this is the first case report of CD4 lymphocytopenia associated PML following chronic hepatitis B infection. [ABSTRACT FROM AUTHOR]

Published
2022
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31. Two-year prospective study on efficacy of various anti-epileptic drugs in drug-resistant epilepsy patients and parameters affecting seizure-freedom in Eastern Indian subcontinent.

Author

Mukherjee, Joydeep, Guha, Gautam, and Saha, Shankar Prasad

Subjects
*PEOPLE with epilepsy, *LONGITUDINAL method, *SUBCONTINENTS, *THERAPEUTICS, *ADULT-child relationships
Abstract

Background: Epilepsy is a disease of suffering. Drug-resistant epilepsy (DRE) takes a heavy toll on patients, family and society in the form of prolonged treatment, expenditure, unemployment and disability. Successful treatment depends on appropriate antiepileptic drug (AED) use in appropriate dosage, which varies in different parts of the world. Aims and Objectives: To find out AED efficacy in Indian subcontinent and factors affecting seizure freedom. Materials and Methods: We explored many characteristics of DRE patients, compared in between seizure-free and seizure-persisting patients to find out the variables more affecting seizure-freedom. We measured minimum effective dose and maximum tolerable dose of different AED in child and adult subgroups in patients of the Indian subcontinent. Results: Lamotrigine was most efficacious in various seizure-types and phenytoin was the least one as first add-on AED. Clobazam was efficacious and good-compliance second add-on AED. AED compliance was significantly reduced as the number of AED was increased above two. AED monotherapy was most effective and the effectiveness decreased as subsequent AED was added as per need. Conclusion: Our study enlightened about various aspects of drug-resistant epilepsy patients in Indian sub-continent and their treatment. [ABSTRACT FROM AUTHOR]

Published
2019
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35. A lady presenting with segmental anhidrosis and heat intolerance.

Author

Kumar, Piyush, Das, Anupam, Mondal, Ashim K., Kumar, Jayant, Chattopadhyay, Saumya Swarup, Guha, Gautam, and Das, Nilay K.

Subjects
ANHIDROSIS, SWEATING-sickness, FACIAL abnormality patients, SWEAT gland diseases, DISEASES in women, DIAGNOSIS
Abstract

The article discusses the case of a 35-year-old lady with the complaints of increased sweating on right side of her face and upper trunk and was diagnosed of Ross syndrome. Topics covered include the medical history of the patient, characteristics of Rose syndrome, and how demonstration of anhidrosis can be done.

Published
2015
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