2,677 results on '"Guglielmo, M."'
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2. Terrestrial Very-Long-Baseline Atom Interferometry: Workshop Summary
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Abend, Sven, Allard, Baptiste, Alonso, Iván, Antoniadis, John, Araujo, Henrique, Arduini, Gianluigi, Arnold, Aidan, Aßmann, Tobias, Augst, Nadja, Badurina, Leonardo, Balaz, Antun, Banks, Hannah, Barone, Michele, Barsanti, Michele, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles, Quentin, Beaufils, Belic, Aleksandar, Beniwal, Ankit, Bernabeu, Jose, Bertinelli, Francesco, Bertoldi, Andrea, Biswas, Ikbal Ahamed, Blas, Diego, Boegel, Patrick, Bogojevic, Aleksandar, Böhm, Jonas, Böhringer, Samuel, Bongs, Kai, Bouyer, Philippe, Brand, Christian, Brimis, Apostolos, Buchmueller, Oliver, Cacciapuoti, Luigi, Calatroni, Sergio, Canuel, Benjamin, Caprini, Chiara, Caramete, Ana, Caramete, Laurentiu, Carlesso, Matteo, Carlton, John, Casariego, Mateo, Charmandaris, Vassilis, Chen, Yu-Ao, Chiofalo, Maria Luisa, Cimbri, Alessia, Coleman, Jonathon, Constantin, Florin Lucian, Contaldi, Carlo, Cui, Yanou, Da Ros, Elisa, Davies, Gavin, Rosendo, Esther del Pino, Deppner, Christian, Derevianko, Andrei, de Rham, Claudia, De Roeck, Albert, Derr, Daniel, Di Pumpo, Fabio, Djordjevic, Goran, Dobrich, Babette, Domokos, Peter, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Duspayev, Alisher, Easo, Sajan, Eby, Joshua, Efremov, Maxim, Ekelof, Tord, Elertas, Gedminas, Ellis, John, Evans, David, Fadeev, Pavel, Fanì, Mattia, Fassi, Farida, Fattori, Marco, Fayet, Pierre, Felea, Daniel, Feng, Jie, Friedrich, Alexander, Fuchs, Elina, Gaaloul, Naceur, Gao, Dongfeng, Gardner, Susan, Garraway, Barry, Gauguet, Alexandre, Gerlach, Sandra, Gersemann, Matthias, Gibson, Valerie, Giese, Enno, Giudice, Gian Francesco, Glasbrenner, Eric, Gündogan, Mustafa, Haehnelt, Martin G., Hakulinen, Timo, Hammerer, Klemens, Hanımeli, Ekim Taylan, Harte, Tiffany, Hawkins, Leonie, Hees, Aurelien, Heise, Jaret, Henderson, Victoria, Herrmann, Sven, Hird, Thomas, Hogan, Jason, Holst, Bodil, Holynski, Michael, Hussain, Kamran, Janson, Gregor, Jeglič, Peter, Jelezko, Fedor, Kagan, Michael, Kalliokoski, Matti, Kasevich, Mark, Kehagias, Alex, Kilian, Eva, Koley, Soumen, Konrad, Bernd, Kopp, Joachim, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Laemmerzahl, Claus, Landsberg, Greg, Langlois, Mehdi, Lanigan, Bryony, Lellouch, Samuel, Leone, Bruno, Lafitte, Christophe Le Poncin, Lewicki, Marek, Leykauf, Bastian, Lezeik, Ali, Lombriser, Lucas, López, Luis, Asamar, Elias López, Monjaraz, Cristian López, Luciano, Gaetano, Mohammed, Mohammed Mahmoud, Maleknejad, Azadeh, Markus, Krutzik, Marteau, Jacques, Massonnet, Didier, Mazumdar, Anupam, McCabe, Christopher, Meister, Matthias, Menu, Jonathan, Messineo, Giuseppe, Micalizio, Salvatore, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Montero, Mario, Morley, Gavin, Müller, Jürgen, Müstecaplıoğlu, Özgür, Ni, Wei-Tou, Noller, Johannes, Odžak, Senad, Oi, Daniel, Omar, Yasser, Pahl, Julia, Paling, Sean, Pandey, Saurabh, Pappas, George, Pareek, Vinay, Pasatembou, Elizabeth, Pelucchi, Emanuele, Santos, Franck Pereira dos, Piest, Baptist, Pikovski, Igor, Pilaftsis, Apostolos, Plunkett, Robert, Poggiani, Rosa, Prevedelli, Marco, Puputti, Julia, Veettil, Vishnupriya Puthiya, Quenby, John, Rafelski, Johann, Rajendran, Surjeet, Rasel, Ernst Maria, Sfar, Haifa Rejeb, Reynaud, Serge, Richaud, Andrea, Rodzinka, Tangui, Roura, Albert, Rudolph, Jan, Sabulsky, Dylan, Safronova, Marianna, Santamaria, Luigi, Schilling, Manuel, Schkolnik, Vladimir, Schleich, Wolfgang, Schlippert, Dennis, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Schwersenz, Nico, Semakin, Aleksei, Sergijenko, Olga, Shao, Lijing, Shipsey, Ian, Singh, Rajeev, Smerzi, Augusto, Sopuerta, Carlos F., Spallicci, Alessandro, Stefanescu, Petruta, Stergioulas, Nikolaos, Ströhle, Jannik, Struckmann, Christian, Tentindo, Silvia, Throssell, Henry, Tino, Guglielmo M., Tinsley, Jonathan, Mircea, Ovidiu Tintareanu, Tkalčec, Kimberly, Tolley, Andrew, Tornatore, Vincenza, Torres-Orjuela, Alejandro, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Ufrecht, Christian, Ulmer, Stefan, Valuch, Daniel, Vaskonen, Ville, Aceves, Veronica Vazquez, Vitanov, Nikolay, Vogt, Christian, von Klitzing, Wolf, Vukics, András, Walser, Reinhold, Wang, Jin, Warburton, Niels, Webber-Date, Alexander, Wenzlawski, André, Werner, Michael, Williams, Jason, Windapssinger, Patrcik, Wolf, Peter, Wörner, Lisa, Xuereb, André, Yahia, Mohamed, Cruzeiro, Emmanuel Zambrini, Zarei, Moslem, Zhan, Mingsheng, Zhou, Lin, Zupan, Jure, and Zupanič, Erik
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High Energy Physics - Experiment ,Astrophysics - Instrumentation and Methods for Astrophysics ,General Relativity and Quantum Cosmology ,High Energy Physics - Phenomenology ,Physics - Atomic Physics - Abstract
This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more km-scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions., Comment: Summary of the Terrestrial Very-Long-Baseline Atom Interferometry Workshop held at CERN: https://indico.cern.ch/event/1208783/
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- 2023
3. STE-QUEST: Space Time Explorer and QUantum Equivalence principle Space Test
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Ahlers, Holger, Badurina, Leonardo, Bassi, Angelo, Battelier, Baptiste, Beaufils, Quentin, Bongs, Kai, Bouyer, Philippe, Braxmaier, Claus, Buchmueller, Oliver, Carlesso, Matteo, Charron, Eric, Chiofalo, Maria Luisa, Corgier, Robin, Donadi, Sandro, Droz, Fabien, Ecoffet, Robert, Ellis, John, Estève, Frédéric, Gaaloul, Naceur, Gerardi, Domenico, Giese, Enno, Grosse, Jens, Hees, Aurélien, Hensel, Thomas, Herr, Waldemar, Jetzer, Philippe, Kleinsteinberg, Gina, Klempt, Carsten, Lecomte, Steve, Lopes, Louise, Loriani, Sina, Métris, Gilles, Martin, Thierry, Martín, Victor, Müller, Gabriel, Nofrarias, Miquel, Santos, Franck Pereira Dos, Rasel, Ernst M., Robert, Alain, Saks, Noah, Salter, Mike, Schlippert, Dennis, Schubert, Christian, Schuldt, Thilo, Sopuerta, Carlos F., Struckmann, Christian, Tino, Guglielmo M., Valenzuela, Tristan, von Klitzing, Wolf, Wörner, Lisa, Wolf, Peter, Yu, Nan, and Zelan, Martin
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Physics - Space Physics ,General Relativity and Quantum Cosmology ,High Energy Physics - Experiment ,High Energy Physics - Phenomenology ,Quantum Physics - Abstract
An M-class mission proposal in response to the 2021 call in ESA's science programme with a broad range of objectives in fundamental physics, which include testing the Equivalence Principle and Lorentz Invariance, searching for Ultralight Dark Matter and probing Quantum Mechanics., Comment: As submitted to the M7 call in July 2022, except updated for the recent (Sept. 2022) MICROSCOPE results, and new section 2.5 summarizing the information provided to ESA during the September 2022 audition
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- 2022
4. Maternal immunity shapes biomarkers of germinal center development in HIV‐exposed uninfected infants
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Li Yin, Guglielmo M. Venturi, Richard Barfield, Bernard M. Fischer, Julie J. Kim-Chang, Cliburn Chan, Kristina De Paris, Maureen M. Goodenow, and John W. Sleasman
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HIV ,pregnancy ,immune development ,A proliferation-inducing ligand (APRIL) ,macrophage ,lymphoid germinal centers ,Immunologic diseases. Allergy ,RC581-607 - Abstract
IntroductionHIV-exposed uninfected (HEU) infants exhibit elevated pro-inflammatory biomarkers that persist after birth. However, comprehensive assessments of bioprofiles associated with immune regulation and development in pregnant women with HIV (PWH) and HEU infants has not been performed. Maternal immunity in PWH may be imprinted on their HEU newborns, altering immune bioprofiles during early immune development.MethodsCryopreserved paired plasma samples from 46 HEU infants and their mothers enrolled in PACTG 316, a clinical trial to prevent perinatal HIV-1 transmission were analyzed. PWH received antiretrovirals (ARV) and had either fully suppressed or unsuppressed viral replication. Maternal blood samples obtained during labor and infant samples at birth and 6 months were measured for 21 biomarkers associated with germinal centers (GC), macrophage activation, T-cell activation, interferon gamma (IFN-γ)-inducible chemokines, and immune regulatory cytokines using Mesoscale assays. Pregnant women without HIV (PWOH) and their HIV unexposed uninfected (HUU) newborns and non-pregnant women without HIV (NPWOH) served as reference groups. Linear regression analysis fitted for comparison among groups and adjusted for covariant(s) along with principal component analysis performed to assess differences among groups.ResultsCompared with NPWOH, PWOH displayed higher levels of GC, macrophage, and regulatory biomarkers. PWH compared to PWOH displayed elevated GC, T cell activation, and IFN-γ-inducible chemokines biomarkers at delivery. Similar to their mothers, HEU infants had elevated GC, macrophage, and IFN-γ-inducible chemokines, as well as elevated anti-inflammatory cytokines, IL-10 and IL-1RA. Across all mother/newborn dyads, multiple biomarkers positively correlated, providing further evidence that maternal inflammation imprints on newborn bioprofiles. By 6 months, many HEU biomarkers normalized to levels similar to HUU infants, but some GC and inflammatory biomarkers remained perturbed. Bioprofiles in PWH and HEU infants were similar regardless of the extent of maternal viral suppression by ARV.ConclusionsGC immune pathways are perturbed in HEU newborns, but immune regulatory responses down regulate inflammation during early infancy, indicating a transient inflammatory effect. However, several GC biomarkers that may alter immune development remain perturbed.
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- 2024
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5. Cold Atoms in Space: Community Workshop Summary and Proposed Road-Map
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Alonso, Ivan, Alpigiani, Cristiano, Altschul, Brett, Araujo, Henrique, Arduini, Gianluigi, Arlt, Jan, Badurina, Leonardo, Balaz, Antun, Bandarupally, Satvika, Barone, Barry C Barish Michele, Barsanti, Michele, Bass, Steven, Bassi, Angelo, Battelier, Baptiste, Baynham, Charles F. A., Beaufils, Quentin, Belic, Aleksandar, Berge, Joel, Bernabeu, Jose, Bertoldi, Andrea, Bingham, Robert, Bize, Sebastien, Blas, Diego, Bongs, Kai, Bouyer, Philippe, Braitenberg, Carla, Brand, Christian, Braxmaier, Claus, Bresson, Alexandre, Buchmueller, Oliver, Budker, Dmitry, Bugalho, Luıs, Burdin, Sergey, Callegari, Luigi Cacciapuoti Simone, Calmet, Xavier, Calonico, Davide, Canuel, Benjamin, Caramete, Laurentiu-Ioan, Carraz, Olivier, Cassettari, Donatella, Chakraborty, Pratik, Chattopadhyay, Swapan, Chauhan, Upasna, Chen, Xuzong, Chen, Yu-Ao, Chiofalo, Maria Luisa, Coleman, Jonathon, Corgier, Robin, Cotter, J. P., Cruise, A. Michael, Cui, Yanou, Davies, Gavin, De Roeck, Albert, Demarteau, Marcel, Derevianko, Andrei, Di Clemente, Marco, Djordjevic, Goran S., Donadi, Sandro, Dore, Olivier, Dornan, Peter, Doser, Michael, Drougakis, Giannis, Dunningham, Jacob, Easo, Sajan, Eby, Joshua, Elertas, Gedminas, Ellis, John, Evans, David, Examilioti, Pandora, Fadeev, Pavel, Fanı, Mattia, Fassi, Farida, Fattori, Marco, Fedderke, Michael A., Felea, Daniel, Feng, Chen-Hao, Ferreras, Jorge, Flack, Robert, Flambaum, Victor V., Forsberg, Rene, Fromhold, Mark, Gaaloul, Naceur, Garraway, Barry M., Georgousi, Maria, Geraci, Andrew, Gibble, Kurt, Gibson, Valerie, Gill, Patrick, Giudice, Gian F., Goldwin, Jon, Gould, Oliver, Grachov, Oleg, Graham, Peter W., Grasso, Dario, Griffin, Paul F., Guerlin, Christine, Gundogan, Mustafa, Gupta, Ratnesh K, Haehnelt, Martin, Hanımeli, Ekim T., Hawkins, Leonie, Hees, Aurelien, Henderson, Victoria A., Herr, Waldemar, Herrmann, Sven, Hird, Thomas, Hobson, Richard, Hock, Vincent, Hogan, Jason M., Holst, Bodil, Holynski, Michael, Israelsson, Ulf, Jeglic, Peter, Jetzer, Philippe, Juzeliunas, Gediminas, Kaltenbaek, Rainer, Kamenik, Jernej F., Kehagias, Alex, Kirova, Teodora, Kiss-Toth, Marton, Koke, Sebastian, Kolkowitz, Shimon, Kornakov, Georgy, Kovachy, Tim, Krutzik, Markus, Kumar, Mukesh, Kumar, Pradeep, Lammerzahl, Claus, Landsberg, Greg, Poncin-Lafitte, Christophe Le, Leibrandt, David R., Leveque, Thomas, Lewicki, Marek, Li, Rui, Lipniacka, Anna, Liu, Christian Lisdat Mia, Lopez-Gonzalez, J. L., Loriani, Sina, Louko, Jorma, Luciano, Giuseppe Gaetano, Lundblad, Nathan, Maddox, Steve, Mahmoud, M. A., Maleknejad, Azadeh, March-Russell, John, Massonnet, Didier, McCabe, Christopher, Meister, Matthias, Meznarsic, Tadej, Micalizio, Salvatore, Migliaccio, Federica, Millington, Peter, Milosevic, Milan, Mitchell, Jeremiah, Morley, Gavin W., Muller, Jurgen, Murphy, Eamonn, Mustecaplıoglu, Ozgur E., OShea, Val, Oi, Daniel K. L., Olson, Judith, Pal, Debapriya, Papazoglou, Dimitris G., Pasatembou, Elizabeth, Paternostro, Mauro, Pawlowski, Krzysztof, Pelucchi, Emanuele, Santos, Franck Pereira dos, Peters, Achim, Pikovski, Igor, Pilaftsis, Apostolos, Pinto, Alexandra, Prevedelli, Marco, Puthiya-Veettil, Vishnupriya, Quenby, John, Rafelski, Johann, Rasel, Ernst M., Ravensbergen, Cornelis, Reguzzoni, Mirko, Richaud, Andrea, Riou, Isabelle, Rothacher, Markus, Roura, Albert, Ruschhaupt, Andreas, Sabulsky, Dylan O., Safronova, Marianna, Saltas, Ippocratis D., Salvi, Leonardo, Sameed, Muhammed, Saurabh, Pandey, Schaffer, Stefan, Schiller, Stephan, Schilling, Manuel, Schkolnik, Vladimir, Schlippert, Dennis, Schmidt, Piet O., Schnatz, Harald, Schneider, Jean, Schneider, Ulrich, Schreck, Florian, Schubert, Christian, Shayeghi, Armin, Sherrill, Nathaniel, Shipsey, Ian, Signorini, Carla, Singh, Rajeev, Singh, Yeshpal, Skordis, Constantinos, Smerzi, Augusto, Sopuerta, Carlos F., Sorrentino, Fiodor, Sphicas, Paraskevas, Stadnik, Yevgeny V., Stefanescu, Petruta, Tarallo, Marco G., Tentindo, Silvia, Tino, Guglielmo M., Tinsley, Jonathan N., Tornatore, Vincenza, Treutlein, Philipp, Trombettoni, Andrea, Tsai, Yu-Dai, Tuckey, Philip, Uchida, Melissa A, Valenzuela, Tristan, Bossche, Mathias Van Den, Vaskonen, Ville, Verma, Gunjan, Vetrano, Flavio, Vogt, Christian, von Klitzing, Wolf, Waller, Pierre, Walser, Reinhold, Williams, Eric Wille Jason, Windpassinger, Patrick, Wittrock, Ulric, Wolf, Peter, Woltmann, Marian, Worner, Lisa, Xuereb, Andre, Yahia, Mohamed, Yazgan, Efe, Yu, Nan, Zahzam, Nassim, Cruzeiro, Emmanuel Zambrini, Zhan, Mingsheng, Zou, Xinhao, Zupan, Jure, and Zupanic, Erik
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Astrophysics - Instrumentation and Methods for Astrophysics ,General Relativity and Quantum Cosmology ,High Energy Physics - Experiment ,High Energy Physics - Phenomenology ,Physics - Atomic Physics - Abstract
We summarize the discussions at a virtual Community Workshop on Cold Atoms in Space concerning the status of cold atom technologies, the prospective scientific and societal opportunities offered by their deployment in space, and the developments needed before cold atoms could be operated in space. The cold atom technologies discussed include atomic clocks, quantum gravimeters and accelerometers, and atom interferometers. Prospective applications include metrology, geodesy and measurement of terrestrial mass change due to, e.g., climate change, and fundamental science experiments such as tests of the equivalence principle, searches for dark matter, measurements of gravitational waves and tests of quantum mechanics. We review the current status of cold atom technologies and outline the requirements for their space qualification, including the development paths and the corresponding technical milestones, and identifying possible pathfinder missions to pave the way for missions to exploit the full potential of cold atoms in space. Finally, we present a first draft of a possible road-map for achieving these goals, that we propose for discussion by the interested cold atom, Earth Observation, fundamental physics and other prospective scientific user communities, together with ESA and national space and research funding agencies., Comment: Summary of the Community Workshop on Cold Atoms in Space and corresponding Road-map: https://indico.cern.ch/event/1064855/
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- 2022
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6. Identical particles exchange symmetry and the electric dipole moment in molecules
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Tino, Guglielmo M.
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Quantum Physics ,Physics - Chemical Physics - Abstract
Based on fundamental symmetries, molecules cannot have a permanent electric dipole moment although it is commonly used in the literature to explain the different molecular spectra for heteronuclear and homonuclear molecules. Electric-dipole rotational and vibrational spectra can indeed be observed in heteronuclear molecules while they are missing in molecules with identical nuclei. I show that the missing spectral features can be explained as an effect of the exchange symmetry for identical particles., Comment: Revised argument, results unchanged. Corrected typos. Added references
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- 2021
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7. Changes in upper airways microbiota in ventilator-associated pneumonia
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Alagna, Laura, Mancabelli, Leonardo, Magni, Federico, Chatenoud, Liliane, Bassi, Gabriele, Del Bianco, Silvia, Fumagalli, Roberto, Turroni, Francesca, Mangioni, Davide, Migliorino, Guglielmo M., Milani, Christian, Muscatello, Antonio, Nattino, Giovanni, Picetti, Edoardo, Pinciroli, Riccardo, Rossi, Sandra, Tonetti, Tommaso, Vargiolu, Alessia, Bandera, Alessandra, Ventura, Marco, Citerio, Giuseppe, and Gori, Andrea
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- 2023
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8. Testing gravity with cold atom interferometry: Results and prospects
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Tino, Guglielmo M.
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General Relativity and Quantum Cosmology ,Physics - Atomic Physics ,Quantum Physics - Abstract
Atom interferometers have been developed in the last three decades as new powerful tools to investigate gravity. They were used for measuring the gravity acceleration, the gravity gradient, and the gravity-field curvature, for the determination of the gravitational constant, for the investigation of gravity at microscopic distances, to test the equivalence principle of general relativity and the theories of modified gravity, to probe the interplay between gravitational and quantum physics and to test quantum gravity models, to search for dark matter and dark energy, and they were proposed as new detectors for the observation of gravitational waves. Here I describe past and ongoing experiments with an outlook on what I think are the main prospects in this field and the potential to search for new physics.
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- 2020
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9. Changes in upper airways microbiota in ventilator-associated pneumonia
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Laura Alagna, Leonardo Mancabelli, Federico Magni, Liliane Chatenoud, Gabriele Bassi, Silvia Del Bianco, Roberto Fumagalli, Francesca Turroni, Davide Mangioni, Guglielmo M. Migliorino, Christian Milani, Antonio Muscatello, Giovanni Nattino, Edoardo Picetti, Riccardo Pinciroli, Sandra Rossi, Tommaso Tonetti, Alessia Vargiolu, Alessandra Bandera, Marco Ventura, Giuseppe Citerio, and Andrea Gori
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Ventilator-associated pneumonia ,VAP ,Upper airways microbiota ,16S-rRNA microbial profiling ,Cohort study ,Mechanical ventilation ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background The role of upper airways microbiota and its association with ventilator-associated pneumonia (VAP) development in mechanically ventilated (MV) patients is unclear. Taking advantage of data collected in a prospective study aimed to assess the composition and over-time variation of upper airway microbiota in patients MV for non-pulmonary reasons, we describe upper airway microbiota characteristics among VAP and NO-VAP patients. Methods Exploratory analysis of data collected in a prospective observational study on patients intubated for non-pulmonary conditions. Microbiota analysis (trough 16S-rRNA gene profiling) was performed on endotracheal aspirates (at intubation, T0, and after 72 h, T3) of patients with VAP (cases cohort) and a subgroup of NO-VAP patients (control cohort, matched according to total intubation time). Results Samples from 13 VAP patients and 22 NO-VAP matched controls were analyzed. At intubation (T0), patients with VAP revealed a significantly lower microbial complexity of the microbiota of the upper airways compared to NO-VAP controls (alpha diversity index of 84 ± 37 and 160 ± 102, in VAP and NO_VAP group, respectively, p-value
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- 2023
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10. Cardiac magnetic resonance in advanced heart failure.
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Coraducci F, De Zan G, Fedele D, Costantini P, Guaricci AI, Pavon AG, Teske A, Cramer MJ, Broekhuizen L, Van Osch D, Danad I, Velthuis B, Suchá D, van der Bilt I, Pizzi C, Russo AD, Oerlemans M, van Laake LW, van der Harst P, and Guglielmo M
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- Humans, Magnetic Resonance Imaging, Cine methods, Heart Failure physiopathology, Heart Failure diagnosis
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Heart failure (HF) is a chronic and progressive disease that often progresses to an advanced stage where conventional therapy is insufficient to relieve patients' symptoms. Despite the availability of advanced therapies such as mechanical circulatory support or heart transplantation, the complexity of defining advanced HF, which requires multiple parameters and multimodality assessment, often leads to delays in referral to dedicated specialists with the result of a worsening prognosis. In this review, we aim to explore the role of cardiac magnetic resonance (CMR) in advanced HF by showing how CMR is useful at every step in managing these patients: from diagnosis to prognostic stratification, hemodynamic evaluation, follow-up and advanced therapies such as heart transplantation. The technical challenges of scanning advanced HF patients, which often require troubleshooting of intracardiac devices and dedicated scans, will be also discussed., (© 2024 The Author(s). Echocardiography published by Wiley Periodicals LLC.)
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- 2024
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11. Progression of non-obstructive coronary plaque: a practical CCTA-based risk score from the PARADIGM registry.
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Pontone G, Rossi A, Baggiano A, Andreini D, Conte E, Fusini L, Gebhard C, Rabbat MG, Guaricci A, Guglielmo M, Muscogiuri G, Mushtaq S, Al-Mallah MH, Berman DS, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, de Araújo Gonçalves P, Gottlieb I, Hadamitzky M, Kim YJ, Lee BK, Lee SE, Maffei E, Marques H, Samady H, Shin S, Sung JM, van Rosendael A, Virmani R, Bax JJ, Leipsic JA, Lin FY, Min JK, Narula J, Shaw LJ, and Chang HJ
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- Humans, Computed Tomography Angiography methods, Coronary Angiography methods, Constriction, Pathologic, Risk Assessment methods, Predictive Value of Tests, Risk Factors, Disease Progression, Registries, Plaque, Atherosclerotic diagnostic imaging, Coronary Stenosis, Coronary Artery Disease diagnostic imaging
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Objectives: No clear recommendations are endorsed by the different scientific societies on the clinical use of repeat coronary computed tomography angiography (CCTA) in patients with non-obstructive coronary artery disease (CAD). This study aimed to develop and validate a practical CCTA risk score to predict medium-term disease progression in patients at a low-to-intermediate probability of CAD., Methods: Patients were part of the Progression of AtheRosclerotic PlAque Determined by Computed Tomographic Angiography Imaging (PARADIGM) registry. Specifically, 370 (derivation cohort) and 219 (validation cohort) patients with two repeat, clinically indicated CCTA scans, non-obstructive CAD, and absence of high-risk plaque (≥ 2 high-risk features) at baseline CCTA were included. Disease progression was defined as the new occurrence of ≥ 50% stenosis and/or high-risk plaque at follow-up CCTA., Results: In the derivation cohort, 104 (28%) patients experienced disease progression. The median time interval between the two CCTAs was 3.3 years (2.7-4.8). Odds ratios for disease progression derived from multivariable logistic regression were as follows: 4.59 (95% confidence interval: 1.69-12.48) for the number of plaques with spotty calcification, 3.73 (1.46-9.52) for the number of plaques with low attenuation component, 2.71 (1.62-4.50) for 25-49% stenosis severity, 1.47 (1.17-1.84) for the number of bifurcation plaques, and 1.21 (1.02-1.42) for the time between the two CCTAs. The C-statistics of the model were 0.732 (0.676-0.788) and 0.668 (0.583-0.752) in the derivation and validation cohorts, respectively., Conclusions: The new CCTA-based risk score is a simple and practical tool that can predict mid-term CAD progression in patients with known non-obstructive CAD., Clinical Relevance Statement: The clinical implementation of this new CCTA-based risk score can help promote the management of patients with non-obstructive coronary disease in terms of timing of imaging follow-up and therapeutic strategies., Key Points: • No recommendations are available on the use of repeat CCTA in patients with non-obstructive CAD. • This new CCTA score predicts mid-term CAD progression in patients with non-obstructive stenosis at baseline. • This new CCTA score can help guide the clinical management of patients with non-obstructive CAD., (© 2023. The Author(s), under exclusive licence to European Society of Radiology.)
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- 2024
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12. Exploring the Foundations of the Universe with Space Tests of the Equivalence Principle
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Battelier, Baptiste, Bergé, Joël, Bertoldi, Andrea, Blanchet, Luc, Bongs, Kai, Bouyer, Philippe, Braxmaier, Claus, Calonico, Davide, Fayet, Pierre, Gaaloul, Naceur, Guerlin, Christine, Hees, Aurélien, Jetzer, Philippe, Lämmerzahl, Claus, Lecomte, Steve, Poncin-Lafitte, Christophe Le, Loriani, Sina, Métris, Gilles, Nofrarias, Miguel, Rasel, Ernst, Reynaud, Serge, Rodrigues, Manuel, Rothacher, Markus, Roura, Albert, Salomon, Christophe, Schiller, Stephan, Schleich, Wolfgang P., Schubert, Christian, Sopuerta, Carlos, Sorrentino, Fiodor, Sumner, Tim J., Tino, Guglielmo M., Tuckey, Philip, von Klitzing, Wolf, Wörner, Lisa, Wolf, Peter, and Zelan, Martin
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Physics - Space Physics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present the scientific motivation for future space tests of the equivalence principle, and in particular the universality of free fall, at the $10^{-17}$ level or better. Two possible mission scenarios, one based on quantum technologies, the other on electrostatic accelerometers, that could reach that goal are briefly discussed., Comment: White paper submitted to the ESA Voyage 2050 long term plan. Partly derived from Altschul et al., Advances in Space Research, 2015, 55, 501 - 524, arXiv:1404.4307
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- 2019
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13. Sr atom interferometry with the optical clock transition as a gravimeter and a gravity gradiometer
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Hu, Liang, Wang, Enlong, Salvi, Leonardo, Tinsley, Jonathan N., Tino, Guglielmo M., and Poli, Nicola
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Physics - Atomic Physics - Abstract
We characterize the performance of a gravimeter and a gravity gradiometer based on the $^{1}$S$_{0}$-$^3$P$_0$ clock transition of strontium atoms. We use this new quantum sensor to measure the gravitational acceleration with a relative sensitivity of $1.7\times10^{-5}$, representing the first realisation of an atomic interferometry gravimeter based on a single-photon transition. Various noise contributions to the gravimeter are measured and characterized, with the current primary limitation to sensitivity seen to be the intrinsic noise of the interferometry laser itself. In a gravity gradiometer configuration, a differential phase sensitivity of 1.53~rad/$\sqrt{Hz}$ was achieved at an artificially introduced differential phase of $\pi/2$~rad. We experimentally investigated the effects of the contrast and visibility based on various parameters and achieve a total interferometry time of 30~ms, which is longer than previously reported for such interferometers. The characterization and determined limitations of the present apparatus employing $^{88}$Sr atoms provides a guidance for the future development of large-scale clock-transition gravimeters and gravity gradiometers with alkali-earth and alkali-earth-like atoms (e.g., $^{87}$Sr, Ca, Yb)., Comment: 32 pages, 14 figures
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- 2019
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14. Linguistic and content validation of the translated and culturally adapted patient-generated subjective global assessment (PG-SGA)
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Ripamonti, C.I., Arena, F., Di Pede, P., Guglielmo, M., Toffolatti, L., Bossi, P., Gandelli, M., Laviano, A., Chiesi, F., and Jager-Wittenaar, H.
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- 2023
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15. Collateral presence and extent do not predict myocardial viability and ischemia in chronic total occlusions: A stress-CMR study
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Pica, S., Di Odoardo, L., Testa, L., Bollati, M., Crimi, G., Camporeale, A., Tondi, L., Pontone, G., Guglielmo, M., Andreini, D., Squeri, A., Monti, L., Roccasalva, F., Grancini, L., Gasparini, G.L., Secco, G.G., Bellini, B., Azzalini, L., Maestroni, A., Bedogni, F., and Lombardi, M.
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- 2023
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16. Biomarkers detected in cord blood predict vaccine responses in young infants
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Carolyn H. Baloh, Guglielmo M. Venturi, Bernard M. Fischer, Liane S. Sadder, Julie J. Kim-Chang, Cliburn Chan, Kristina De Paris, Li Yin, Grace M. Aldrovandi, Maureen M. Goodenow, and John W. Sleasman
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human infants ,immune development ,A proliferation-inducing ligand (APRIL) ,macrophage ,tetanus vaccine ,B cell ,Immunologic diseases. Allergy ,RC581-607 - Abstract
IntroductionFactors influencing vaccine immune priming in the first year of life involve both innate and adaptive immunity but there are gaps in understanding how these factors sustain vaccine antibody levels in healthy infants. The hypothesis was that bioprofiles associated with B cell survival best predict sustained vaccine IgG levels at one year.MethodsLongitudinal study of plasma bioprofiles in 82 term, healthy infants, who received standard recommended immunizations in the United States, with changes in 15 plasma biomarker concentrations and B cell subsets associated with germinal center development monitored at birth, soon after completion of the initial vaccine series at 6 months, and prior to the 12-month vaccinations. Post vaccination antibody IgG levels to Bordetella pertussis, tetanus toxoid, and conjugated Haemophilus influenzae type B (HiB) were outcome measures.ResultsUsing a least absolute shrinkage and selection operator (lasso) regression model, cord blood (CB) plasma IL-2, IL-17A, IL-31, and soluble CD14 (sCD14) were positively associated with pertussis IgG levels at 12 months, while CB plasma concentrations of APRIL and IL-33 were negatively associated. In contrast, CB concentrations of sCD14 and APRIL were positively associated with sustained tetanus IgG levels. A separate cross-sectional analysis of 18 mother/newborn pairs indicated that CB biomarkers were not due to transplacental transfer, but rather due to immune activation at the fetal/maternal interface. Elevated percentages of cord blood switched memory B cells were positively associated with 12-month HiB IgG levels. BAFF concentrations at 6 and 12 months were positively associated with pertussis and HiB IgG levels respectively.DiscussionSustained B cell immunity is highly influenced by early life immune dynamics beginning prior to birth. The findings provide important insights into how germinal center development shapes vaccine responses in healthy infants and provide a foundation for studies of conditions that impair infant immune development.
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- 2023
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17. Terrestrial very-long-baseline atom interferometry: Workshop summary
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Abend, Sven, primary, Allard, Baptiste, additional, Alonso, Iván, additional, Antoniadis, John, additional, Araújo, Henrique, additional, Arduini, Gianluigi, additional, Arnold, Aidan S., additional, Asano, Tobias, additional, Augst, Nadja, additional, Badurina, Leonardo, additional, Balaž, Antun, additional, Banks, Hannah, additional, Barone, Michele, additional, Barsanti, Michele, additional, Bassi, Angelo, additional, Battelier, Baptiste, additional, Baynham, Charles F. A., additional, Beaufils, Quentin, additional, Belić, Aleksandar, additional, Beniwal, Ankit, additional, Bernabeu, Jose, additional, Bertinelli, Francesco, additional, Bertoldi, Andrea, additional, Biswas, Ikbal Ahamed, additional, Blas, Diego, additional, Boegel, Patrick, additional, Bogojević, Aleksandar, additional, Böhm, Jonas, additional, Böhringer, Samuel, additional, Bongs, Kai, additional, Bouyer, Philippe, additional, Brand, Christian, additional, Brimis, Apostolos, additional, Buchmueller, Oliver, additional, Cacciapuoti, Luigi, additional, Calatroni, Sergio, additional, Canuel, Benjamin, additional, Caprini, Chiara, additional, Caramete, Ana, additional, Caramete, Laurentiu, additional, Carlesso, Matteo, additional, Carlton, John, additional, Casariego, Mateo, additional, Charmandaris, Vassilis, additional, Chen, Yu-Ao, additional, Chiofalo, Maria Luisa, additional, Cimbri, Alessia, additional, Coleman, Jonathon, additional, Constantin, Florin Lucian, additional, Contaldi, Carlo R., additional, Cui, Yanou, additional, Ros, Elisa Da, additional, Davies, Gavin, additional, Rosendo, Esther del Pino, additional, Deppner, Christian, additional, Derevianko, Andrei, additional, Rham, Claudia de, additional, Roeck, Albert De, additional, Derr, Daniel, additional, Di Pumpo, Fabio, additional, Djordjevic, Goran S., additional, Döbrich, Babette, additional, Domokos, Peter, additional, Dornan, Peter, additional, Doser, Michael, additional, Drougakis, Giannis, additional, Dunningham, Jacob, additional, Duspayev, Alisher, additional, Easo, Sajan, additional, Eby, Joshua, additional, Efremov, Maxim, additional, Ekelof, Tord, additional, Elertas, Gedminas, additional, Ellis, John, additional, Evans, David, additional, Fadeev, Pavel, additional, Fanì, Mattia, additional, Fassi, Farida, additional, Fattori, Marco, additional, Fayet, Pierre, additional, Felea, Daniel, additional, Feng, Jie, additional, Friedrich, Alexander, additional, Fuchs, Elina, additional, Gaaloul, Naceur, additional, Gao, Dongfeng, additional, Gardner, Susan, additional, Garraway, Barry, additional, Gauguet, Alexandre, additional, Gerlach, Sandra, additional, Gersemann, Matthias, additional, Gibson, Valerie, additional, Giese, Enno, additional, Giudice, Gian F., additional, Glasbrenner, Eric P., additional, Gündoğan, Mustafa, additional, Haehnelt, Martin, additional, Hakulinen, Timo, additional, Hammerer, Klemens, additional, Hanımeli, Ekim T., additional, Harte, Tiffany, additional, Hawkins, Leonie, additional, Hees, Aurelien, additional, Heise, Jaret, additional, Henderson, Victoria A., additional, Herrmann, Sven, additional, Hird, Thomas M., additional, Hogan, Jason M., additional, Holst, Bodil, additional, Holynski, Michael, additional, Hussain, Kamran, additional, Janson, Gregor, additional, Jeglič, Peter, additional, Jelezko, Fedor, additional, Kagan, Michael, additional, Kalliokoski, Matti, additional, Kasevich, Mark, additional, Kehagias, Alex, additional, Kilian, Eva, additional, Koley, Soumen, additional, Konrad, Bernd, additional, Kopp, Joachim, additional, Kornakov, Georgy, additional, Kovachy, Tim, additional, Krutzik, Markus, additional, Kumar, Mukesh, additional, Kumar, Pradeep, additional, Lämmerzahl, Claus, additional, Landsberg, Greg, additional, Langlois, Mehdi, additional, Lanigan, Bryony, additional, Lellouch, Samuel, additional, Leone, Bruno, additional, Poncin-Lafitte, Christophe Le, additional, Lewicki, Marek, additional, Leykauf, Bastian, additional, Lezeik, Ali, additional, Lombriser, Lucas, additional, Luis Lopez-Gonzalez, J., additional, Lopez Asamar, Elias, additional, Monjaraz, Cristian López, additional, Luciano, Giuseppe Gaetano, additional, Mahmoud, M. A., additional, Maleknejad, Azadeh, additional, Marteau, Jacques, additional, Massonnet, Didier, additional, Mazumdar, Anupam, additional, McCabe, Christopher, additional, Meister, Matthias, additional, Menu, Jonathan, additional, Messineo, Giuseppe, additional, Micalizio, Salvatore, additional, Millington, Peter, additional, Milosevic, Milan, additional, Mitchell, Jeremiah, additional, Montero, Mario, additional, Morley, Gavin W., additional, Müller, Jürgen, additional, ioğlu, Özgür E. Müstecapl, additional, Ni, Wei-Tou, additional, Noller, Johannes, additional, Odžak, Senad, additional, Oi, Daniel K. L., additional, Omar, Yasser, additional, Pahl, Julia, additional, Paling, Sean, additional, Pandey, Saurabh, additional, Pappas, George, additional, Pareek, Vinay, additional, Pasatembou, Elizabeth, additional, Pelucchi, Emanuele, additional, Pereira dos Santos, Franck, additional, Piest, Baptist, additional, Pikovski, Igor, additional, Pilaftsis, Apostolos, additional, Plunkett, Robert, additional, Poggiani, Rosa, additional, Prevedelli, Marco, additional, Puputti, Julia, additional, Veettil, Vishnupriya Puthiya, additional, Quenby, John, additional, Rafelski, Johann, additional, Rajendran, Surjeet, additional, Rasel, Ernst M., additional, Sfar, Haifa Rejeb, additional, Reynaud, Serge, additional, Richaud, Andrea, additional, Rodzinka, Tangui, additional, Roura, Albert, additional, Rudolph, Jan, additional, Sabulsky, Dylan O., additional, Safronova, Marianna S., additional, Santamaria, Luigi, additional, Schilling, Manuel, additional, Schkolnik, Vladimir, additional, Schleich, Wolfgang P., additional, Schlippert, Dennis, additional, Schneider, Ulrich, additional, Schreck, Florian, additional, Schubert, Christian, additional, Schwersenz, Nico, additional, Semakin, Aleksei, additional, Sergijenko, Olga, additional, Shao, Lijing, additional, Shipsey, Ian, additional, Singh, Rajeev, additional, Smerzi, Augusto, additional, Sopuerta, Carlos F., additional, Spallicci, Alessandro D. A. M., additional, Stefanescu, Petruta, additional, Stergioulas, Nikolaos, additional, Ströhle, Jannik, additional, Struckmann, Christian, additional, Tentindo, Silvia, additional, Throssell, Henry, additional, Tino, Guglielmo M., additional, Tinsley, Jonathan N., additional, Tintareanu Mircea, Ovidiu, additional, Tkalčec, Kimberly, additional, Tolley, Andrew. J., additional, Tornatore, Vincenza, additional, Torres-Orjuela, Alejandro, additional, Treutlein, Philipp, additional, Trombettoni, Andrea, additional, Tsai, Yu-Dai, additional, Ufrecht, Christian, additional, Ulmer, Stefan, additional, Valuch, Daniel, additional, Vaskonen, Ville, additional, Vázquez-Aceves, Verónica, additional, Vitanov, Nikolay V., additional, Vogt, Christian, additional, Klitzing, Wolf von, additional, Vukics, András, additional, Walser, Reinhold, additional, Wang, Jin, additional, Warburton, Niels, additional, Webber-Date, Alexander, additional, Wenzlawski, André, additional, Werner, Michael, additional, Williams, Jason, additional, Windpassinger, Patrick, additional, Wolf, Peter, additional, Woerner, Lisa, additional, Xuereb, André, additional, Yahia, Mohamed E., additional, Cruzeiro, Emmanuel Zambrini, additional, Zarei, Moslem, additional, Zhan, Mingsheng, additional, Zhou, Lin, additional, Zupan, Jure, additional, and Zupanič, Erik, additional
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- 2024
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18. Using cardiac magnetic resonance feature tracking to discover novel abnormalities in patients with idiopathic ventricular fibrillation
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Verheul, L, primary, Guglielmo, M, additional, Groeneveld, S A, additional, Prakken, N H J, additional, Velthuis, B K, additional, and Hassink, R J, additional
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- 2024
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19. Bragg gravity-gradiometer using the $^1$S$_0$-$^3$P$_1$ intercombination transition of $^{88}$Sr
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del Aguila, Ruben P., Mazzoni, Tommaso, Hu, Liang, Salvi, Leonardo, Tino, Guglielmo M., and Poli, Nicola
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Physics - Atomic Physics - Abstract
We present a gradiometer based on matter-wave interference of alkaline-earth-metal atoms, namely $^{88}$Sr. The coherent manipulation of the atomic external degrees of freedom is obtained by large-momentum-transfer Bragg diffraction, driven by laser fields detuned away from the narrow $^1$S$_0$-$^3$P$_1$ intercombination transition. We use a well-controlled artificial gradient, realized by changing the relative frequencies of the Bragg pulses during the interferometer sequence, in order to characterize the sensitivity of the gradiometer. The sensitivity reaches $1.5 \times 10^{-5}$ s$^{-2}$ for an interferometer time of 20 ms, limited only by geometrical constraints. We observed extremely low sensitivity of the gradiometric phase to magnetic field gradients, approaching a value 10$^{5}$ times lower than the sensitivity of alkali-atom based gradiometers. An efficient double-launch technique employing accelerated red vertical lattices from a single magneto-optical trap cloud is also demonstrated. These results highlight strontium as an ideal candidate for precision measurements of gravity gradients, with potential application in future precision tests of fundamental physics., Comment: 10 pages, 7 figures
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- 2017
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20. Cardiac magnetic resonance for early atrial lesion visualization post atrial fibrillation radiofrequency catheter ablation.
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Guglielmo M, Rier S, Zan G, Krafft AJ, Schmidt M, Kunze KP, Botnar RM, Prieto C, van der Heijden J, Van Driel V, Ramanna H, van der Harst P, and van der Bilt I
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- Humans, Male, Middle Aged, Aged, Female, Contrast Media, Treatment Outcome, Gadolinium, Magnetic Resonance Spectroscopy, Atrial Fibrillation diagnostic imaging, Atrial Fibrillation surgery, Catheter Ablation adverse effects, Catheter Ablation methods, Pulmonary Veins diagnostic imaging, Pulmonary Veins surgery
- Abstract
Background: Incomplete atrial lesions resulting in pulmonary vein-left atrium reconnection after pulmonary vein antrum isolation (PVAI), are related to atrial fibrillation (AF) recurrence. Unfortunately, during the PVAI procedure, fluoroscopy and electroanatomic mapping cannot accurately determine the location and size of the ablation lesions in the atrial wall and this can result in incomplete PVAI lesions (PVAI-L) after radiofrequency catheter ablation (RFCA)., Aim: We seek to evaluate whether cardiac magnetic resonance (CMR), immediately after RFCA of AF, can identify PVAI-L by characterizing the left atrial tissue., Methods: Ten patients (63.1 ± 5.7 years old, 80% male) receiving a RFCA for paroxysmal AF underwent a CMR before (<1 week) and after (<1 h) the PVAI. Two-dimensional dark-blood T2-weighted short tau inversion recovery (DB-STIR), Three-dimensional inversion-recovery prepared long inversion time (3D-TWILITE) and three-dimensional late gadolinium enhancement (3D-LGE) images were performed to visualize PVAI-L., Results: The PVAI-L was visible in 10 patients (100%) using 3D-TWILITE and 3D-LGE. Conversely, On DB-STIR, the ablation core of the PAVI-L could not be identified because of a diffuse high signal of the atrial wall post-PVAI. Microvascular obstruction was identified in 7 (70%) patients using 3D-LGE., Conclusion: CMR can visualize PVAI-L immediately after the RFCA of AF even without the use of contrast agents. Future studies are needed to understand if the use of CMR for PVAI-L detection after RFCA can improve the results of ablation procedures., (© 2023 Wiley Periodicals LLC.)
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- 2024
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21. Tracing the stellar component of low surface brightness Milky Way Dwarf Galaxies to their outskirts I: Sextans
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Cicuendez, L., Battaglia, G., Irwin, M., Bermejo-Climent, J. R., McMonigal, B., Bate, N. F., Lewis, G. F., Conn, A. R., de Boer, T. J. L., Gallart, C., Guglielmo, M., Ibata, R., McConnachie, A., Tolstoy, E., and Fernando, N.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present results from deep and very spatially extended CTIO/DECam $g$ and $r$ photometry (reaching out to $\sim$ 2 mag below the oldest MSTO and covering $\sim$ 20 deg$^2$) around the Sextans dSph. We use this data-set to study the structural properties of Sextans overall stellar population and its different stellar evolutionary phases, as well as to search for signs of tidal disturbance from the MW, which would indicate departure from dynamical equilibrium. We perform the most accurate structural analysis to-date of Sextans' stellar components by applying Bayesian MCMC methods to the individual stars' positions. Surface density maps are built by decontaminating the sample through a matched filter analysis of the CMD, and then analysed for departures from axisymmetry. Sextans is found to be considerably less spatially extended than early studies suggested. No significant distortions or tidal disturbances are found down to a surface brightness of $\sim$ 31.8 mag/arcsec$^{-2}$ in V-band. We identify an overdensity in the central regions that may correspond to previously reported kinematic substructure(s). In agreement with previous findings, old $\&$ metal-poor stars such as BHB stars cover a much larger area than stars in other evolutionary phases, and bright BSs are less spatially extended than faint ones. However, the different spatial distribution of bright and faint BSs appears consistent with the general age/metallicity gradients found in Sextans' stellar component. This is compatible with BSs having formed by evolution of binaries and not necessarily due to the presence of a central disrupted globular cluster, as suggested in the literature. We provide structural parameters for the various populations analyzed and make publicly available the photometric catalogue of point-sources as well as a catalogue of literature spectroscopic measurements with updated membership probabilities., Comment: 21 pages, 14 figures, 9 tables, accepted for publication in Astronomy & Astrophysics (A&A), the associated photometric and spectroscopic catalogues will be available at CDS, abstract abridged for arXiv
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- 2017
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22. Squeezing on momentum states for atom interferometry
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Salvi, Leonardo, Poli, Nicola, Vuletic, Vladan, and Tino, Guglielmo M.
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Physics - Atomic Physics - Abstract
We propose and analyse a method that allows for the production of squeezed states of the atomic center-of-mass motion that can be injected into an atom interferometer. Our scheme employs dispersive probing in a ring resonator on a narrow transition of strontium atoms in order to provide a collective measurement of the relative population of two momentum states. We show that this method is applicable to a Bragg diffraction-based atom interferometer with large diffraction orders. The applicability of this technique can be extended also to small diffraction orders and large atom numbers by inducing atomic transparency at the frequency of the probe field, reaching an interferometer phase resolution scaling $\Delta\phi\sim N^{-3/4}$, where $N$ is the atom number. We show that for realistic parameters it is possible to obtain a 20 dB gain in interferometer phase estimation compared to the Standard Quantum Limit., Comment: 5 pages, 4 figures
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- 2017
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23. Atom interferometry with the Sr optical clock transition
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Hu, Liang, Poli, Nicola, Salvi, Leonardo, and Tino, Guglielmo M.
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Physics - Atomic Physics - Abstract
We report on the realization of a matter-wave interferometer based on single-photon interaction on the ultra-narrow optical clock transition of strontium atoms. We experimentally demonstrated its operation as a gravimeter and as a gravity gradiometer. No reduction of interferometric contrast was observed up to an interferometer time $2T=10$ ms, limited by geometric constraints of the apparatus. In the gradiometric configuration, the sensitivity approaches the shot noise limit. Single-photon interferometers represent a new class of high-precision sensors that could be used for the detection of gravitational waves in so far unexplored frequency ranges and to enlighten the boundary between Quantum Mechanics and General Relativity., Comment: 5 pages, 4 figures
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- 2017
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24. Mitral Annular Disjunction in Idiopathic Ventricular Fibrillation Patients: Just a Bystander or a Potential Cause?
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Verheul, L M, primary, Guglielmo, M, additional, Groeneveld, S A, additional, Kirkels, F P, additional, Scrocco, C, additional, Cramer, M J, additional, Bootsma, M, additional, Kapel, G F L, additional, Alings, M, additional, Evertz, R, additional, Mulder, B A, additional, Prakken, N H J, additional, Balt, J C, additional, Volders, P G A, additional, Hirsch, A, additional, Yap, S C, additional, Postema, P G, additional, Nijveldt, R, additional, Velthuis, B K, additional, Behr, E R, additional, Wilde, A A M, additional, and Hassink, R J, additional
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- 2024
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25. Review of: "Forecasting by Analogy: A Parallel between the Trend of Confirmed COVID-19 Deaths in the Winters of 2022/2023 and 2023/2024 in Italy"
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Trovato, Guglielmo M, primary
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- 2024
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26. A Deep Learning Approach In The Identification Of Myocardial Fibrosis From Early Contrast-Enhanced Cardiac Ct Images
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carerj, M., primary, Penso, M., additional, Guglielmo, M., additional, Babbaro, M., additional, Baggiano, A., additional, Moccia, S., additional, Pepi, M., additional, Caiani, E., additional, and Pontone, G., additional
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- 2024
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27. Stress Computed Tomography Perfusion Versus Stress Cardiac Magnetic Resonance For The Management Of Suspected Or Known Coronary Arterydisease: Resources And Outcomes Impact (Strategy II Study)
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Baggiano, A., primary, Maragna, R., additional, Guglielmo, M., additional, Mushtaq, S., additional, Annoni, A., additional, Formenti, A., additional, Mancini, M., additional, Fusini, L., additional, Volpe, A., additional, Tassetti, L., additional, Marchetti, F., additional, Junod, D., additional, Fazzari, F., additional, Cannata, F., additional, Del Torto, A., additional, Guaricci, A., additional, and Pontone, G., additional
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- 2024
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28. A trapped atom interferometer with ultracold Sr atoms
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Zhang, Xian, del Aguila, Ruben Pablo, Mazzoni, Tommaso, Poli, Nicola, and Tino, Guglielmo M.
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Physics - Atomic Physics - Abstract
We report on a trapped atom interferometer based on Bragg diffraction and Bloch oscillations with alkaline-earth-metal atoms. We use a Ramsey-Bord\'e Bragg interferometer with $^{88}$Sr atoms combined with Bloch oscillations to extend the interferometer time. Thanks to a long coherence time for Bloch oscillations of $^{88}$Sr atoms, we observed interference up to 1 s evolution time in the lattice. A detailed study of decoherence sources during the Bloch phase is also presented. While still limited in sensitivity by lattice lifetime and beam inhomogeneity this result opens the way to high contrast trapped interferometers with extended interrogation time., Comment: 9 pages, 8 figures, Accepted for publication in Phys. Rev. A
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- 2016
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29. Exploring the foundations of the physical universe with space tests of the equivalence principle
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Battelier, Baptiste, Bergé, Joël, Bertoldi, Andrea, Blanchet, Luc, Bongs, Kai, Bouyer, Philippe, Braxmaier, Claus, Calonico, Davide, Fayet, Pierre, Gaaloul, Naceur, Guerlin, Christine, Hees, Aurélien, Jetzer, Philippe, Lämmerzahl, Claus, Lecomte, Steve, Le Poncin-Lafitte, Christophe, Loriani, Sina, Métris, Gilles, Nofrarias, Miquel, Rasel, Ernst, Reynaud, Serge, Rodrigues, Manuel, Rothacher, Markus, Roura, Albert, Salomon, Christophe, Schiller, Stephan, Schleich, Wolfgang P., Schubert, Christian, Sopuerta, Carlos F., Sorrentino, Fiodor, Sumner, Timothy J., Tino, Guglielmo M., Tuckey, Philip, Klitzing, Wolf von, Wörner, Lisa, Wolf, Peter, and Zelan, Martin
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- 2021
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30. Nanotechnology and Its Application in Dentistry: A Systematic Review of Recent Advances and Innovations.
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Dipalma G, Inchingolo AD, Guglielmo M, Morolla R, Palumbo I, Riccaldo L, Mancini A, Palermo A, Malcangi G, Inchingolo AM, and Inchingolo F
- Abstract
Background: This study looks at the clinical applications of nanotechnology in dentistry, with an emphasis on implantology, preventive care, orthodontics, restorative dentistry, and endodontics. Methods: Following PRISMA criteria and registered in PROSPERO (ID: CRD 564245), a PubMed, Scopus, and Web of Science search was conducted for studies from January 2014 to April 2024. The criteria were English-language research on nanotechnology in dental coatings, with a focus on clinical trials and observational studies. The electronic database search yielded 8881 publications. Following the screening process, 17 records were selected for qualitative analysis. Results: Nanotechnology has revolutionized dentistry. In orthodontics, nanoparticles improve antibacterial characteristics, durability, and biocompatibility, lowering bacterial colonization and plaque. In preventative care, Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) combined with stannous fluoride (SnF
2 ) and nano-sized sodium trimetaphosphate (TMPnano) substantially remineralizes enamel. Nanostructured surfaces in dental implants, particularly those containing calcium, improve osseointegration and stability. Nanoparticles in restorative dentistry improve composite and adhesive strength, aesthetics, and longevity. Conclusions: Nanotechnology improves dental materials and equipment, resulting in better treatment outcomes and increased patient comfort. Its integration provides more effective treatments, which improves dental care and patient outcomes. More research is needed to overcome present problems and expand nanotechnology's medicinal applications.- Published
- 2024
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31. Diagnostic accuracy of non-invasive cardiac imaging modalities in patients with a history of coronary artery disease: a meta-analysis.
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Jukema RA, Dahdal J, Kooijman EM, Wahedi E, de Winter RW, Guglielmo M, Cramer MJ, van der Harst P, Remmelzwaal S, Raijmakers P, Knaapen P, and Danad I
- Abstract
Background: The diagnostic performance of non-invasive imaging techniques for detecting obstructive coronary artery disease (CAD) in patients with a history of myocardial infarction or percutaneous coronary intervention has not been comprehensively evaluated. This meta-analysis assesses the diagnostic value of coronary CT angiography (CCTA), CCTA combined with CT perfusion (CCTA+CTP), cardiac MRI (CMR) and single-photon emission CT (SPECT) compared with invasive reference standards., Methods: We systematically searched PubMed, Embase, Web of Science and the Cochrane Library from 2005 to September 2022 for prospective, blinded studies including populations with ≥50% prior CAD., Results: We identified 18 studies encompassing 3265 patients, with obstructive CAD present in 64%. The per-patient sensitivity of CCTA (0.95; 95% CI 0.92 to 0.98), CCTA+CTP (0.93; 95% CI 0.84 to 0.98) and CMR (0.91; 95% CI 0.86 to 0.94) was high, while SPECT showed lower sensitivity (0.63; 95% CI 0.52 to 0.73). SPECT had higher specificity compared with CCTA (0.66; 95% CI 0.56 to 0.76 vs 0.37; 95% CI 0.29 to 0.46), but was comparable to CCTA+CTP (0.59; 95% CI 0.49 to 0.69) and CMR (0.69; 95% CI 0.53 to 0.81). The area under the curve for SPECT was the lowest (0.70; 95% CI 0.58 to 0.87), while CCTA (0.91; 95% CI 0.86 to 0.98), CCTA+CTP (0.89; 95% CI 0.73 to 1.00) and CMR (0.91; 95% CI 0.80 to 1.00) showed similar high values., Conclusions: In patients with prior CAD, CCTA, CCTA+CTP and CMR demonstrated high diagnostic performance, whereas SPECT had lower sensitivity. These findings can guide the selection of non-invasive imaging techniques in this high-risk population., Prospero Registration Number: CRD42022322348., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2024
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32. STress computed tomogRaphy perfusion and stress cArdiac magnetic resonance for ThE manaGement of suspected or known coronarY artery disease: resources and outcomes impact.
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Baggiano A, Baessato F, Mushtaq S, Annoni AD, Cannata F, Carerj ML, Del Torto A, Fazzari F, Formenti A, Frappampina A, Fusini L, Junod D, Mancini ME, Mantegazza V, Maragna R, Marchetti F, Sbordone FP, Tassetti L, Volpe A, Guglielmo M, Rossi A, Rovera C, Rabbat MG, Guaricci AI, Cau C, Saba L, Berna G, Sforza C, Pepi M, and Pontone G
- Abstract
Background: The aim of this study is to describe resources and outcomes of coronary computed tomography angiography plus Stress CT perfusion (CCTA + Stress-CTP) and stress cardiovascular magnetic resonance (Stress-CMR) in symptomatic patients with suspected or known CAD., Methods: Six hundred and twenty-four consecutive symptomatic patients with intermediate to high-risk pretest likelihood for CAD or previous history of revascularization referred to our hospital for clinically indicated CCTA + Stress-CTP or Stress-CMR were enrolled. Stress-CTP scans were performed in 223 patients while 401 patients performed Stress-CMR. Patient follow-up was performed at 1 year after index test performance. Endpoints were all cardiac events, as a combined endpoint of revascularization, non-fatal MI and death, and hard cardiac events, as combined endpoint of non-fatal MI and death., Results: Twenty-nine percent of patients who underwent CCTA + Stress-CTP received revascularization, 7% of subjects assessed with Stress-CMR were treated invasively, and a low number of non-fatal MI and death was observed with both strategies (hard events in 0.4% of patients that had CCTA + Stress-CTP as index test, and in 3% of patients evaluated with Stress-CMR). According to the predefined endpoints, CCTA + Stress-CTP group showed high rate of all cardiac events and low rate of hard cardiac events, respectively. The cumulative costs were 1970 ± 2506 Euro and 733 ± 1418 Euro for the CCTA + Stress-CTP group and Stress-CMR group, respectively., Conclusions: The use of CCTA + Stress-CTP strategy was associated with high referral to revascularization but with a favourable trend in terms of hard cardiac events and diagnostic yield in identifying individuals at lower risk of adverse events despite the presence of CAD., Competing Interests: Declaration of competing interest All authors have nothing to disclose., (Copyright © 2024 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.)
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- 2024
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33. Prognostic significance of echocardiographic deformation imaging in adult congenital heart disease.
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van Rosendael PJ, Taha K, Guglielmo M, Teske AJ, van der Harst P, Sieswerda G, Cramer MJ, and van der Zwaan HB
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- Humans, Prognosis, Adult, Tetralogy of Fallot diagnostic imaging, Tetralogy of Fallot surgery, Ebstein Anomaly diagnostic imaging, Ebstein Anomaly physiopathology, Arrhythmias, Cardiac diagnostic imaging, Heart Transplantation, Heart Defects, Congenital diagnostic imaging, Echocardiography methods, Heart Failure diagnostic imaging
- Abstract
Background: Due to medical and surgical advancements, the population of adult patients with congenital heart disease (ACHD) is growing. Despite successful therapy, ACHD patients face structural sequalae, placing them at increased risk for heart failure and arrhythmias. Left and right ventricular function are important predictors for adverse clinical outcomes. In acquired heart disease it has been shown that echocardiographic deformation imaging is of superior prognostic value as compared to conventional parameters as ejection fraction. However, in adult congenital heart disease, the clinical significance of deformation imaging has not been systematically assessed and remains unclear., Methods: According to the Preferred Reporting Items for Systematic Reviews checklist, this systematic review included studies that reported on the prognostic value of echocardiographic left and/or right ventricular strain by 2-dimensional speckle tracking for hard clinical end-points (death, heart failure hospitalization, arrhythmias) in the most frequent forms of adult congenital heart disease., Results: In total, 19 contemporary studies were included. Current data shows that left ventricular and right ventricular global longitudinal strain (GLS) predict heart failure, transplantation, ventricular arrhythmias and mortality in patients with Ebstein's disease and tetralogy of Fallot, and that GLS of the systemic right ventricle predicts heart failure and mortality in patients post atrial switch operation or with a congenitally corrected transposition of the great arteries., Conclusions: Deformation imaging can potentially impact the clinical decision making in ACHD patients. Further studies are needed to establish disease-specific reference strain values and ranges of impaired strain that would indicate the need for medical or structural intervention., (© 2024 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.)
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- 2024
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34. AI-Derived Stress Ejection Fraction in Stress-CMR with Dipyridamole: Bridging Past Insights with Future Innovations.
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Guglielmo M and Pavon AG
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- 2024
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35. Effect of N-acetyl cysteine in children with metabolic dysfunction-associated steatotic liver disease-A pilot study.
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Babu Balagopal P, Kohli R, Uppal V, Averill L, Shah C, McGoogan K, Di Guglielmo M, Goran M, and Hossain MJ
- Abstract
Background: Prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as nonalcoholic fatty liver disease (NAFLD), and its sequelae of more severe forms such as metabolic dysfunction-associated steatohepatitis (MASH) is rapidly increasing in children with the rise in obesity. Successful and sustainable treatments for MASLD are lacking in children. We determined the therapeutic effect of N-acetyl cysteine (NAC) on biomarkers of oxidative stress, inflammation and insulin resistance (IR), liver enzymes, liver fat fraction (LFF) and (LS) in children with obesity and biopsy-confirmed MASLD., Methods: Thirteen children (n = 13; age: 13.6 ± 2.8 years; NAS score >2) underwent a double-blind, placebo-controlled trial of NAC (either 600 or 1200 mg NAC/day) or placebo for 16 weeks. Measurements included LFF (magnetic resonance imaging), LS (ultrasound elastography), and body composition. Erythrocyte glutathione (GSH), liver enzymes, insulin, glucose, adiponectin, high-sensitivity c-reactive protein (hs-CRP), and interleukin-6 (IL-6) were also measured. HOMA-IR was calculated., Results: Sixteen-week NAC treatment improved (baseline adjusted between-group p < .05 for all) markers of inflammation (IL-6 and hs-CRP), oxidative stress (GSH), and insulin resistance (HOMA-IR) and reduced liver enzymes, LFF and LS. Body weight and body composition did not show beneficial changes., Conclusions: Sixteen-week NAC treatment was well tolerated in children with obesity and MASLD and led to improvements in oxidative stress, inflammation and IR and liver outcomes. The results from this pilot study support further investigation of NAC as a therapeutic agent in children with MASLD., (© 2024 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.)
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- 2024
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36. Diagnostic value of late gadolinium enhancement at cardiovascular magnetic resonance to distinguish arrhythmogenic right ventricular cardiomyopathy from differentials.
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Rekker LY, Muller SA, Gasperetti A, Bourfiss M, Oerlemans MIFJ, Cramer MJ, Zimmerman SL, Dooijes D, Schalkx H, van der Harst P, James CA, van Tintelen JP, Guglielmo M, Velthuis BK, and Te Riele ASJM
- Abstract
Background: While late gadolinium enhancement (LGE) is proposed as a diagnostic criterion for arrhythmogenic right ventricular cardiomyopathy (ARVC), the potential of LGE to distinguish ARVC from differentials remains unknown. We aimed to assess the diagnostic value of LGE for ARVC diagnosis., Methods: We included 132 subjects (60% male, 47 ± 11 years) who had undergone cardiac magnetic resonance imaging with LGE assessment for ARVC or ARVC differentials. ARVC was diagnosed as per 2010 Task Force Criteria (n = 55). ARVC differentials consisted of familial/genetic dilated cardiomyopathy (n = 25), myocarditis (n = 13), sarcoidosis (n = 20), and amyloidosis (n = 19). The diagnosis of all differentials was based on the most current standard of reference. The presence of LGE was evaluated using a 7-segment right ventricle (RV) and 17-segment left ventricle (LV) model. Subsequently, we assessed LGE patterns for every patient individually for fulfilling LV- and/or RV-LGE per Padua criteria, independent of their clinical diagnosis (i.e. phenotype). Diagnostic values were analyzed using sensitivity and specificity for any RV-LGE, any LV-LGE, RV-LGE per Padua criteria, and prevalence graphs for LV-LGE per Padua criteria. The optimal integration of LGE for ARVC diagnosis was determined using classification and regression tree analysis., Results: One-third (38%) of ARVC patients had RV-LGE, while half (51%) had LV-LGE. RV-LGE was less frequently observed in ARVC vs non-ARVC patients (38% vs 58%, p = 0.034) leading to a poor discriminatory potential (any RV-LGE: sensitivity 38%, specificity 42%; RV-LGE per Padua criteria: sensitivity 36%, specificity 44%). Compared to ARVC patients, non-ARVC patients more often had LV-LGE (91% vs 51%, p < 0.001) which was also more globally distributed (median 9 [interquartile range (IQR): 3-13] vs 0 [IQR: 0-3] segments, p < 0.001). The absence of anteroseptal and absence of extensive (≥5 segments) mid-myocardial LV-LGE, and absence of moderate (≥2 segments) mid-myocardial LV-LGE predicted ARVC with good diagnostic performance (sensitivity 93%, specificity 78%)., Conclusion: LGE is often present in ARVC differentials and may lead to false positive diagnoses when used without knowledge of LGE patterns. Moderate RV-LGE without anteroseptal and mid-myocardial LV-LGE is typically observed in ARVC., Competing Interests: Declaration of competing interests The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. A.G. has served as part of the advisory board of LEXEO Therapeutics for unrelated work. The remaining authors have no conflict of interest., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
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- 2024
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37. Macroscopic quantum resonators (MAQRO): 2015 Update
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Kaltenbaek, Rainer, Arndt, Markus, Aspelmeyer, Markus, Barker, Peter F., Bassi, Angelo, Bateman, James, Bongs, Kai, Bose, Sougato, Braxmaier, Claus, Brukner, Časlav, Christophe, Bruno, Chwalla, Michael, Cohadon, Pierre-François, Cruise, Adrian M., Curceanu, Catalina, Dholakia, Kishan, Döringshoff, Klaus, Ertmer, Wolfgang, Gieseler, Jan, Gürlebeck, Norman, Hechenblaikner, Gerald, Heidmann, Antoine, Herrmann, Sven, Hossenfelder, Sabine, Johann, Ulrich, Kiesel, Nikolai, Kim, Myungshik, Lämmerzahl, Claus, Lambrecht, Astrid, Mazilu, Michael, Milburn, Gerard J., Müller, Holger, Novotny, Lukas, Paternostro, Mauro, Peters, Achim, Pikovski, Igor, Pilan-Zanoni, André, Rasel, Ernst M., Reynaud, Serge, Riedel, C. Jess, Rodrigues, Manuel, Rondin, Loïc, Roura, Albert, Schleich, Wolfgang P., Schmiedmayer, Jörg, Schuldt, Thilo, Schwab, Keith C., Tajmar, Martin, Tino, Guglielmo M., Ulbricht, Hendrik, Ursin, Rupert, and Vedral, Vlatko
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Quantum Physics - Abstract
Do the laws of quantum physics still hold for macroscopic objects - this is at the heart of Schr\"odinger's cat paradox - or do gravitation or yet unknown effects set a limit for massive particles? What is the fundamental relation between quantum physics and gravity? Ground-based experiments addressing these questions may soon face limitations due to limited free-fall times and the quality of vacuum and microgravity. The proposed mission MAQRO may overcome these limitations and allow addressing those fundamental questions. MAQRO harnesses recent developments in quantum optomechanics, high-mass matter-wave interferometry as well as state-of-the-art space technology to push macroscopic quantum experiments towards their ultimate performance limits and to open new horizons for applying quantum technology in space. The main scientific goal of MAQRO is to probe the vastly unexplored "quantum-classical" transition for increasingly massive objects, testing the predictions of quantum theory for truly macroscopic objects in a size and mass regime unachievable in ground-based experiments. The hardware for the mission will largely be based on available space technology. Here, we present the MAQRO proposal submitted in response to the (M4) Cosmic Vision call of the European Space Agency for a medium-size mission opportunity with a possible launch in 2025., Comment: 38 pages, 10 tables, 23 figures
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- 2015
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38. Design of a dual species atom interferometer for space
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Schuldt, Thilo, Schubert, Christian, Krutzik, Markus, Bote, Lluis Gesa, Gaaloul, Naceur, Hartwig, Jonas, Ahlers, Holger, Herr, Waldemar, Posso-Trujillo, Katerine, Rudolph, Jan, Seidel, Stephan, Wendrich, Thijs, Ertmer, Wolfgang, Herrmann, Sven, Kubelka-Lange, André, Milke, Alexander, Rievers, Benny, Rocco, Emanuele, Hinton, Andrew, Bongs, Kai, Oswald, Markus, Franz, Matthias, Hauth, Matthias, Peters, Achim, Bawamia, Ahmad, Wicht, Andreas, Battelier, Baptiste, Bertoldi, Andrea, Bouyer, Philippe, Landragin, Arnaud, Massonnet, Didier, Lévèque, Thomas, Wenzlawski, Andre, Hellmig, Ortwin, Windpassinger, Patrick, Sengstock, Klaus, von Klitzing, Wolf, Chaloner, Chris, Summers, David, Ireland, Philip, Mateos, Ignacio, Sopuerta, Carlos F., Sorrentino, Fiodor, Tino, Guglielmo M., Williams, Michael, Trenkel, Christian, Gerardi, Domenico, Chwalla, Michael, Burkhardt, Johannes, Johann, Ulrich, Heske, Astrid, Wille, Eric, Gehler, Martin, Cacciapuoti, Luigi, Gürlebeck, Norman, Braxmaier, Claus, and Rasel, Ernst
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Physics - Instrumentation and Detectors ,General Relativity and Quantum Cosmology ,Physics - Atomic Physics ,Physics - Space Physics ,Quantum Physics - Abstract
Atom interferometers have a multitude of proposed applications in space including precise measurements of the Earth's gravitational field, in navigation & ranging, and in fundamental physics such as tests of the weak equivalence principle (WEP) and gravitational wave detection. While atom interferometers are realized routinely in ground-based laboratories, current efforts aim at the development of a space compatible design optimized with respect to dimensions, weight, power consumption, mechanical robustness and radiation hardness. In this paper, we present a design of a high-sensitivity differential dual species $^{85}$Rb/$^{87}$Rb atom interferometer for space, including physics package, laser system, electronics and software. The physics package comprises the atom source consisting of dispensers and a 2D magneto-optical trap (MOT), the science chamber with a 3D-MOT, a magnetic trap based on an atom chip and an optical dipole trap (ODT) used for Bose-Einstein condensate (BEC) creation and interferometry, the detection unit, the vacuum system for $10^{-11}$ mbar ultra-high vacuum generation, and the high-suppression factor magnetic shielding as well as the thermal control system. The laser system is based on a hybrid approach using fiber-based telecom components and high-power laser diode technology and includes all laser sources for 2D-MOT, 3D-MOT, ODT, interferometry and detection. Manipulation and switching of the laser beams is carried out on an optical bench using Zerodur bonding technology. The instrument consists of 9 units with an overall mass of 221 kg, an average power consumption of 608 W (819 W peak), and a volume of 470 liters which would well fit on a satellite to be launched with a Soyuz rocket, as system studies have shown., Comment: 30 pages, 23 figures, accepted for publication in Experimental Astronomy
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- 2014
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39. Editorial: Lung Ultrasound in the Diagnosis of Infective Lung Diseases
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Guglielmo M. Trovato and Marco Sperandeo
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pleural effusion ,digital health (eHealth) ,digital medicine ,fake news ,pneumonitis ,COVID-19 ,Medicine (General) ,R5-920 - Published
- 2022
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40. Cancer-related fatigue: ESMO Clinical Practice Guidelines for diagnosis and treatment
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Fabi, A., Bhargava, R., Fatigoni, S., Guglielmo, M., Horneber, M., Roila, F., Weis, J., Jordan, K., and Ripamonti, C.I.
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- 2020
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41. Review of: "Procurement Planning & the Rwanda Biomedical Centre (RBC)"
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Trovato, Guglielmo M, primary
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- 2023
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42. Review of: "Decolonisation of Health in East Africa: Opinion Piece"
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Trovato, Guglielmo M, primary
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- 2023
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43. Stress computed tomography perfusion versus stress cardiac magnetic resonance for the management of suspected or known coronary artery disease: resources and outcomes impact (STRATEGY II Study)
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Baggiano, A, primary, Guglielmo, M, additional, Mushtaq, S, additional, Annoni, A, additional, Formenti, A, additional, Mancini, E, additional, Fusini, L, additional, Tassetti, L, additional, Volpe, A, additional, Marchetti, F, additional, Cilia, F, additional, Fazzari, F, additional, Maragna, R, additional, Junod, D, additional, and Pontone, G, additional
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- 2023
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44. Identical Particles Exchange Symmetry and the Electric Dipole Moment in Molecules
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Guglielmo M. Tino
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electric dipole moment ,molecular spectra ,fundamental symmetries ,identical particles ,Mathematics ,QA1-939 - Abstract
Based on fundamental symmetries, molecules cannot have a permanent electric dipole moment, although it is commonly used in the literature to explain the different molecular spectra for heteronuclear and homonuclear molecules. Electric-dipole rotational and vibrational spectra can indeed be observed in heteronuclear molecules, while they are missing in molecules with identical nuclei. This paper shows that the missing spectral features can be explained as an effect of the exchange symmetry for identical particles.
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- 2022
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45. COVID-19 Pneumonia: The Great Ultrasonography Mimicker
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Donato Lacedonia, Carla Maria Irene Quarato, Antonio Mirijello, Guglielmo M. Trovato, Anna Del Colle, Gaetano Rea, Giulia Scioscia, Maria Pia Foschino Barbaro, and Marco Sperandeo
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lung ultrasound ,chest computed tomography ,COVID-19 pneumonia ,COVID-19 pneumonia mimickers ,specificity ,Medicine (General) ,R5-920 - Abstract
The pandemic spread of the new severe acute respiratory syndrome coronavirus 2 has raised the necessity to identify an appropriate imaging method for early diagnosis of coronavirus disease 2019 (COVID-19). Chest computed tomography (CT) has been regarded as the mainstay of imaging evaluation for pulmonary involvement in the early phase of the pandemic. However, due to the poor specificity of the radiological pattern and the disruption of radiology centers' functionality linked to an excessive demand for exams, the American College of Radiology has advised against CT use for screening purposes. Lung ultrasound (LUS) is a point-of-care imaging tool that is quickly available and easy to disinfect. These advantages have determined a “pandemic” increase of its use for early detection of COVID-19 pneumonia in emergency departments. However, LUS findings in COVID-19 patients are even less specific than those detectable on CT scans. The scope of this perspective article is to discuss the great number of diseases and pathologic conditions that may mimic COVID-19 pneumonia on LUS examination.
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- 2021
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46. Contained sinus of Valsalva hematoma: an unusual entity leading to acute heart failure.
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Costantini P, Fedele D, Carriero A, and Guglielmo M
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- 2024
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47. The Role of Multimodality Imaging (CT & MR) as a Guide to the Management of Chronic Coronary Syndromes.
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Tassetti L, Sfriso E, Torlone F, Baggiano A, Mushtaq S, Cannata F, Del Torto A, Fazzari F, Fusini L, Junod D, Maragna R, Volpe A, Carrabba N, Conte E, Guglielmo M, La Mura L, Pergola V, Pedrinelli R, Indolfi C, Sinagra G, Perrone Filardi P, Guaricci AI, and Pontone G
- Abstract
Chronic coronary syndrome (CCS) is one of the leading cardiovascular causes of morbidity, mortality, and use of medical resources. After the introduction by international guidelines of the same level of recommendation to non-invasive imaging techniques in CCS evaluation, a large debate arose about the dilemma of choosing anatomical (with coronary computed tomography angiography (CCTA)) or functional imaging (with stress echocardiography (SE), cardiovascular magnetic resonance (CMR), or nuclear imaging techniques) as a first diagnostic evaluation. The determinant role of the atherosclerotic burden in defining cardiovascular risk and prognosis more than myocardial inducible ischemia has progressively increased the use of a first anatomical evaluation with CCTA in a wide range of pre-test probability in CCS patients. Functional testing holds importance, both because the role of revascularization in symptomatic patients with proven ischemia is well defined and because functional imaging, particularly with stress cardiac magnetic resonance (s-CMR), gives further prognostic information regarding LV function, detection of myocardial viability, and tissue characterization. Emerging techniques such as stress computed tomography perfusion (s-CTP) and fractional flow reserve derived from CT (FFRCT), combining anatomical and functional evaluation, appear capable of addressing the need for a single non-invasive examination, especially in patients with high risk or previous revascularization. Furthermore, CCTA in peri-procedural planning is promising to acquire greater importance in the non-invasive planning and guiding of complex coronary revascularization procedures, both by defining the correct strategy of interventional procedure and by improving patient selection. This review explores the different roles of non-invasive imaging techniques in managing CCS patients, also providing insights into preoperative planning for percutaneous or surgical myocardial revascularization.
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- 2024
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48. First experience with a vendor-neutral three-dimensional mapping system for cardiac magnetic resonance-guided electrophysiological procedures: a case report.
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De Zan G, de Jongh M, Karloci V, Guglielmo M, and van der Bilt I
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Background: Fluoroscopy-guided catheter ablation has become the gold standard for treatment of cardiac arrhythmias. High resolution electro-anatomical mapping systems have become fundamental to perform these procedures. Recently, interventional cardiac magnetic resonance (iCMR) has been proposed as an alternative for fluoroscopy to guide atrial flutter ablations. The clinical experience with iCMR and dedicated three-dimensional mapping systems is growing. NorthStar is currently the first available vendor-neutral mapping system., Case Summary: We performed a real-time CMR-guided cavotricuspid isthmus (CTI) catheter ablation (CA) on a 69-year-old man using a novel mapping system (NorthStar Mapping System, Imricor Medical Systems, MN, USA). Starting from the CMR imaging, a pre-rendered segmentation model was loaded on NorthStar and used to guide the catheters, display voltage and activation maps, show mapping and ablation points. NorthStar can also take full control of the CMR scanner (i.e. start/stop sequences for anatomical information, tissue characterization, and catheter visualization) and communicate with the recorder/stimulator system (Advantage-MR EP, Imricor Medical Systems, MN, USA). With comparable procedural time to standard fluoroscopy-guided CA, CTI bidirectional block was achieved, without any complication., Discussion: Using the NorthStar Mapping System, we managed to achieve a successful CMR-guided CTI ablation without any complication. Its further use should be explored, especially in more complex arrhythmias where a substrate-guided ablation is critical, as it could significantly improve results in terms of arrhythmia recurrence., Competing Interests: Conflict of interest: V.K. is employed by Imricor Medical System (MN, USA)., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
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- 2024
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49. Mitral annular disjunction in idiopathic ventricular fibrillation patients: just a bystander or a potential cause?
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Verheul LM, Guglielmo M, Groeneveld SA, Kirkels FP, Scrocco C, Cramer MJ, Bootsma M, Kapel GFL, Alings M, Evertz R, Mulder BA, Prakken NHJ, Balt JC, Volders PGA, Hirsch A, Yap SC, Postema PG, Nijveldt R, Velthuis BK, Behr ER, Wilde AAM, and Hassink RJ
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- Humans, Female, Male, Retrospective Studies, Middle Aged, Adult, Magnetic Resonance Imaging, Cine methods, Mitral Valve diagnostic imaging, Cohort Studies, Mitral Valve Prolapse diagnostic imaging, Mitral Valve Prolapse complications, Prevalence, Risk Assessment, Ventricular Fibrillation diagnostic imaging
- Abstract
Aims: Previously, we demonstrated that inferolateral mitral annular disjunction (MAD) is more prevalent in patients with idiopathic ventricular fibrillation (IVF) than in healthy controls. In the present study, we advanced the insights into the prevalence and ventricular arrhythmogenicity by inferolateral MAD in an even larger IVF cohort., Methods and Results: This retrospective multi-centre study included 185 IVF patients [median age 39 (27, 52) years, 40% female]. Cardiac magnetic resonance images were analyzed for mitral valve and annular abnormalities and late gadolinium enhancement. Clinical characteristics were compared between patients with and without MAD. MAD in any of the 4 locations was present in 112 (61%) IVF patients and inferolateral MAD was identified in 24 (13%) IVF patients. Mitral valve prolapse (MVP) was found in 13 (7%) IVF patients. MVP was more prevalent in patients with inferolateral MAD compared with patients without inferolateral MAD (42 vs. 2%, P < 0.001). Pro-arrhythmic characteristics in terms of a high burden of premature ventricular complexes (PVCs) and non-sustained ventricular tachycardia (VT) were more prevalent in patients with inferolateral MAD compared to patients without inferolateral MAD (67 vs. 23%, P < 0.001 and 63 vs. 41%, P = 0.046, respectively). Appropriate implantable cardioverter defibrillator therapy during follow-up was comparable for IVF patients with or without inferolateral MAD (13 vs. 18%, P = 0.579)., Conclusion: A high prevalence of inferolateral MAD and MVP is a consistent finding in this large IVF cohort. The presence of inferolateral MAD is associated with a higher PVC burden and non-sustained VTs. Further research is needed to explain this potential interplay., Competing Interests: Conflict of interest: A.H. received a research grant and consultancy fees from GE Healthcare and speaker fees from GE Healthcare and Bayer. He is also a member of the medical advisory board of Medis Medical Imaging Systems and was MRI corelab supervisor of Cardialysis BV until 2022. E.R.B. has consulted for Boston Scientific. S.C.Y. is a consultant for Boston Scientific and has received lecture fees and research grants from Medtronic, Biotronik, and Boston Scientific. The other authors have no conflicts of interest to disclose, (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
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- 2024
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50. Advancing Postoperative Pain Management in Oral Cancer Patients: A Systematic Review.
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Inchingolo AM, Dipalma G, Inchingolo AD, Palumbo I, Guglielmo M, Morolla R, Mancini A, and Inchingolo F
- Abstract
The goal of this review is to shed light on the management of orofacial discomfort after a cancer diagnosis in the head and neck region. A search was conducted on PubMed, Scopus, and Web of Science to identify studies on postoperative pain control in oral cancer. The review included open-access research, investigations into pain management, randomized clinical trials, retrospective studies, case-control studies, prospective studies, English-written studies, and full-text publications. Exclusion criteria included animal studies; in vitro studies; off-topic studies; reviews, case reports, letters, or comments; and non-English language. Three reviewers independently accessed databases and assigned a quality rating to the chosen articles. The review explores postoperative pain management in oral cancer patients; highlighting persistent opioid use; the efficacy of adjuvant drugs, such as gabapentin; and a multimodal approach. It emphasizes the need for personalized pain management, recognizing individual pain perception and tailoring interventions. Integrating pharmacological and non-pharmacological strategies is crucial for comprehensive pain management. The review also serves as a guide for future research, emphasizing the need for standardized methodologies and diverse participant populations.
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- 2024
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