49 results on '"Guchhait, Sankar K."'
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2. Molecular medicinal insights into scaffold hopping-based drug discovery success
3. Organocatalyzed umpolung addition for synthesis of heterocyclic-fused arylidene-imidazolones as anticancer agents
4. Natural‐Product‐Inspired Discovery of Trimethoxyphenyl‐1,2,4‐triazolosulfonamides as Potent Tubulin Polymerization Inhibitors
5. Molecular medicinal insights into scaffold hopping-based drug discovery success
6. Pharmacoinformatics analysis of merbarone binding site in human topoisomerase IIα
7. Molecular editing of NSC-666719 enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents.
8. Natural‐Product‐Inspired Discovery of Trimethoxyphenyl‐1,2,4‐triazolosulfonamides as Potent Tubulin Polymerization Inhibitors.
9. Molecular editing of NSC-666719enabling discovery of benzodithiazinedioxide-guanidines as anticancer agentsElectronic supplementary information (ESI) available. CCDC 2269969. For ESI and crystallographic data in CIF or other electronic format see DOI: https://doi.org/10.1039/d3md00648d
10. Scaffold-hopping of bioactive flavonoids: Discovery of aryl-pyridopyrimidinones as potent anticancer agents that inhibit catalytic role of topoisomerase IIα
11. Identification of leads for antiproliferative activity on MDA-MB-435 human breast cancer cells through pharmacophore and CYP1A1-mediated metabolism
12. Late‐Stage CH Activation–Functionalization of Drugs, Natural Products, and Biomolecules: In View of Molecular Property and Mechanistic Pathway
13. A Core‐Linker‐Polyamine (CLP) Strategy Enables Rapid Discovery of Antileishmanial Aminoalkylquinolinecarboxamides That Target Oxidative Stress Mechanism
14. Synthesis of Heterocyclic‐Fused Furans and Dihydrofurans via (4+1)‐Annulation with Ylide: Exploration of Unique Reactivity Behavior of α‐Carbonyl Sulfoxonium Ylide
15. A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a C(sp3)H–N synthon efficiently constructs indolylisoindolinones
16. Identification of 2-arylquinazolines with alkyl-polyamine motifs as potent antileishmanial agents: synthesis and biological evaluation studies
17. Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and apoptotic effects
18. A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a C(sp3)H–N synthon efficiently constructs indolylisoindolinones.
19. Annulation of Conjugated Azine-Imine with a Sulfoxonium Ylide in a Noncarbenoid Route to Synthesize Multisubstituted Imidazole-Fused Heterocycles
20. Microtubule‐targeting agents impair kinesin‐2‐dependent nuclear transport of β‐catenin: Evidence of inhibition of Wnt/β‐catenin signaling as an important antitumor mechanism of microtubule‐targeting agents
21. C12, a combretastatin-A4 analog, exerts anticancer activity by targeting microtubules
22. Identification of 2-arylquinazolines with alkyl-polyamine motifs as potent antileishmanial agents: synthesis and biological evaluation studiesElectronic supplementary information (ESI) available. See DOI: 10.1039/d1md00336d
23. C‐12 Binds to Tubulin at the Colchicine‐binding Site and Target Microtubules by Preferentially Binding to GTP‐bound Tubulin
24. Combretastatin-Inspired Heterocycles as Antitubulin Anticancer Agents
25. Synthesis of Polyfunctionalized Pyrroles via a Tandem Reaction of Michael Addition and Intramolecular Cyanide-Mediated Nitrile-to-Nitrile Condensation
26. Drug-Clinical Agent Molecular Hybrid: Synthesis of Diaryl(trifluoromethyl)pyrazoles as Tubulin Targeting Anticancer Agents
27. A Combretastatin Analogue C12 Binds to Colchicine Site in Tubulin, Inhibits Spindle Microtubule Dynamics, Activates Mitotic Checkpoint and Induces Apoptosis in Cancer Cells
28. Synthesis of Polysubstituted 2-Aminoimidazoles via Alkene-Diamination of Guanidine with Conjugated α-Bromoalkenones
29. A nitrile-stabilized ammonium ylide as a masked C–CN synthon in heterocyclization with amidine–imine: 3-component assembly to fused pyrimidine scaffolds
30. Pyridine C3-arylation of nicotinic acids accessible via a multicomponent reaction: an entry to all-substituted-3,4-diarylated pyridines
31. ChemInform Abstract: A Reaction of 1,2‐Diamines and Aldehydes with Silyl Cyanide as Cyanide Pronucleophile to Access 2‐Aminopyrazines and 2‐Aminoquinoxalines.
32. Scaffold-Hopping of Aurones: 2-Arylideneimidazo[1,2-a]pyridinones as Topoisomerase IIα-Inhibiting Anticancer Agents
33. ChemInform Abstract: Oxidative Dearomatization of Indoles via Pd-Catalyzed C-H Oxygenation: An Entry to C2-Quaternary Indolin-3-ones.
34. Oxidative Dearomatization of Indoles via Pd-Catalyzed C–H Oxygenation: An Entry to C2-Quaternary Indolin-3-ones
35. Novel Combretastatin-2-aminoimidazole Analogues as Potent Tubulin Assembly Inhibitors: Exploration of Unique Pharmacophoric Impact of Bridging Skeleton and Aryl Moiety
36. ChemInform Abstract: Pd‐Catalyzed Ag(I)‐Promoted C3‐Arylation of Pyrido[1,2‐a]pyrimidin‐4‐ones with Bromo/Iodo‐Arenes.
37. A reaction of 1,2-diamines and aldehydes with silyl cyanide as cyanide pronucleophile to access 2-aminopyrazines and 2-aminoquinoxalines
38. ChemInform Abstract: Synthesis of 2-Arylpyridopyrimidinones, 6-Aryluracils, and Tri- and Tetrasubstituted Conjugated Alkenes via Pd-Catalyzed Enolic C-O Bond Activation-Arylation.
39. Pd-Catalyzed Ag(I)-Promoted C3-Arylation of Pyrido[1,2-a]pyrimidin-4-ones with Bromo/Iodo-Arenes
40. Synthesis of 2-Arylpyridopyrimidinones, 6-Aryluracils, and Tri- and Tetrasubstituted Conjugated Alkenes via Pd-Catalyzed Enolic C–O Bond Activation–Arylation
41. Switch in Site of Inhibition: A Strategy for Structure-Based Discovery of Human Topoisomerase IIα Catalytic Inhibitors
42. ChemInform Abstract: Desilylative Activation of TMSCN in Chemoselective Strecker—Ugi Type Reaction: Functional Fused Imidazoles as Building Blocks as an Entry Route to Annulated Purines.
43. Scaffold-hopping and hybridization based design and building block strategic synthesis of pyridine-annulated purines: discovery of novel apoptotic anticancer agents
44. ChemInform Abstract: α,β-Epoxy Esters in Multiple C-O/C-N Bond-Breaking/Formation with 2-Aminopyridines; Synthesis of Biologically Relevant (Z)-2-Methyleneimidazo[1,2-a]pyridin-3-ones.
45. Desilylative activation of TMSCN in chemoselective Strecker–Ugi type reaction: functional fused imidazoles as building blocks as an entry route to annulated purines.
46. Scaffold overlay of flavonoid-inspired molecules: Discovery of 2,3-diaryl-pyridopyrimidin-4-imine/ones as dual hTopo-II and tubulin targeting anticancer agents.
47. A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a C (sp 3 ) H-N synthon efficiently constructs indolylisoindolinones.
48. A nitrile-stabilized ammonium ylide as a masked C-C[double bond, length as m-dash]N synthon in heterocyclization with amidine-imine: 3-component assembly to fused pyrimidine scaffolds.
49. Scaffold-Hopping of Aurones: 2-Arylideneimidazo[1,2- a ]pyridinones as Topoisomerase IIα-Inhibiting Anticancer Agents.
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