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Your search keyword '"Gruza, Mariusz M."' showing total 2 results
Start Over Author "Gruza, Mariusz M." Publication Year Range Last 10 years
2 results on '"Gruza, Mariusz M."'

1. Discovery of selective, orally bioavailable inhibitor of mouse chitotriosidase

Author

Mazur, Marzena, Bartoszewicz, Agnieszka, Dymek, Barbara, Salamon, Magdalena, Andryianau, Gleb, Kowalski, Michał, Olejniczak, Sylwia, Matyszewski, Krzysztof, Pluta, Elżbieta, Borek, Bartłomiej, Stefaniak, Filip, Zagozdzon, Agnieszka, Mazurkiewicz, Marcin, Koralewski, Robert, Czestkowski, Wojciech, Piotrowicz, Michał, Niedziejko, Piotr, Gruza, Mariusz M., Dzwonek, Karolina, Golebiowski, Adam, Golab, Jakub, and Olczak, Jacek

Published
2018
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2. Synthesis and Physicochemical Characterization of the Impurities of Pemetrexed Disodium, an Anticancer Drug.

Author

Michalak, Olga, Gruza, Mariusz M., Witkowska, Anna, Bujak, Iwona, and Cmoch, Piotr

Subjects
*PEMETREXED, *MULTIPLE sclerosis, *ANTINEOPLASTIC agents, *NUCLEAR magnetic resonance, *SODIUM dichromate, *PATIENTS
Abstract

A physicochemical characterization of the process-related impurities associated with the synthesis of pemetrexed disodium was performed. The possibility of pemetrexed impurities forming has been mentioned in literature, but no study on their structure has been published yet. This paper describes the development of the synthesis methods for these compounds and discusses their structure elucidation on the basis of two-dimensional NMR experiments and MS data. The identification of these impurities should be useful for the quality control during the production of the pemetrexed disodium salt. [ABSTRACT FROM AUTHOR]

Published
2015
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