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345 results on '"Gram, Inger T."'

1. Smoking and pancreatic cancer: a sex-specific analysis in the Multiethnic Cohort study

Author: Gram, Inger T., Park, Song-Yi, Wilkens, Lynne R., Le Marchand, Loïc, and Setiawan, Veronica Wendy
Published: 2023
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2. Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer

Author: Mukama, Trasias, Fortner, Renée Turzanski, Katzke, Verena, Hynes, Lucas Cory, Petrera, Agnese, Hauck, Stefanie M., Johnson, Theron, Schulze, Matthias, Schiborn, Catarina, Rostgaard-Hansen, Agnetha Linn, Tjønneland, Anne, Overvad, Kim, Pérez, María José Sánchez, Crous-Bou, Marta, Chirlaque, María-Dolores, Amiano, Pilar, Ardanaz, Eva, Watts, Eleanor L., Travis, Ruth C., Sacerdote, Carlotta, Grioni, Sara, Masala, Giovanna, Signoriello, Simona, Tumino, Rosario, Gram, Inger T., Sandanger, Torkjel M., Sartor, Hanna, Lundin, Eva, Idahl, Annika, Heath, Alicia K., Dossus, Laure, Weiderpass, Elisabete, and Kaaks, Rudolf
Published: 2022
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3. Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort

Author: Cairat, Manon, Rinaldi, Sabina, Navionis, Anne-Sophie, Romieu, Isabelle, Biessy, Carine, Viallon, Vivian, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Severi, Gianluca, Kvaskoff, Marina, Fortner, Renée T., Kaaks, Rudolf, Aleksandrova, Krasimira, Schulze, Matthias B., Masala, Giovanna, Tumino, Rosario, Sieri, Sabina, Grasso, Chiara, Mattiello, Amalia, Gram, Inger T., Olsen, Karina Standahl, Agudo, Antonio, Etxezarreta, Pilar Amiano, Sánchez, Maria-Jose, Santiuste, Carmen, Barricarte, Aurelio, Monninkhof, Evelyn, Hiensch, Anouk E., Muller, David, Merritt, Melissa A., Travis, Ruth C., Weiderpass, Elisabete, Gunter, Marc J., and Dossus, Laure
Published: 2022
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4. Prospective analysis of circulating metabolites and endometrial cancer risk

Author: Dossus, Laure, Kouloura, Eirini, Biessy, Carine, Viallon, Vivian, Siskos, Alexandros P., Dimou, Niki, Rinaldi, Sabina, Merritt, Melissa A., Allen, Naomi, Fortner, Renee, Kaaks, Rudolf, Weiderpass, Elisabete, Gram, Inger T., Rothwell, Joseph A., Lécuyer, Lucie, Severi, Gianluca, Schulze, Matthias B., Nøst, Therese Haugdahl, Crous-Bou, Marta, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra M., Gurrea, Aurelio Barricarte, Schmidt, Julie A., Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Vermeulen, Roel, Heath, Alicia K., Christakoudi, Sofia, Tsilidis, Konstantinos K., Travis, Ruth C., Gunter, Marc J., and Keun, Hector C.
Published: 2021
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5. Smoking Cessation and Short- and Longer-Term Mortality

Author: Cho, Eo Rin, primary, Brill, Ilene K., additional, Gram, Inger T., additional, Brown, Patrick E., additional, and Jha, Prabhat, additional
Published: 2024
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6. Supplementary Table 1 from The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author: Trabert, Britton, primary, Tworoger, Shelley S., primary, O'Brien, Katie M., primary, Townsend, Mary K., primary, Fortner, Renée T., primary, Iversen, Edwin S., primary, Hartge, Patricia, primary, White, Emily, primary, Amiano, Pilar, primary, Arslan, Alan A., primary, Bernstein, Leslie, primary, Brinton, Louise A., primary, Buring, Julie E., primary, Dossus, Laure, primary, Fraser, Gary E., primary, Gaudet, Mia M., primary, Giles, Graham G., primary, Gram, Inger T., primary, Harris, Holly R., primary, Bolton, Judith Hoffman, primary, Idahl, Annika, primary, Jones, Michael E., primary, Kaaks, Rudolf, primary, Kirsh, Victoria A., primary, Knutsen, Synnove F., primary, Kvaskoff, Marina, primary, Lacey, James V., primary, Lee, I-Min, primary, Milne, Roger L., primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Riboli, Elio, primary, Robien, Kim, primary, Rohan, Thomas E., primary, Sandler, Dale P., primary, Schairer, Catherine, primary, Schouten, Leo J., primary, Setiawan, Veronica W., primary, Swerdlow, Anthony J., primary, Travis, Ruth C., primary, Trichopoulou, Antonia, primary, van den Brandt, Piet A., primary, Visvanathan, Kala, primary, Wilkens, Lynne R., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, and Wentzensen, Nicolas, primary
Published: 2023
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7. Data from The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author: Trabert, Britton, primary, Tworoger, Shelley S., primary, O'Brien, Katie M., primary, Townsend, Mary K., primary, Fortner, Renée T., primary, Iversen, Edwin S., primary, Hartge, Patricia, primary, White, Emily, primary, Amiano, Pilar, primary, Arslan, Alan A., primary, Bernstein, Leslie, primary, Brinton, Louise A., primary, Buring, Julie E., primary, Dossus, Laure, primary, Fraser, Gary E., primary, Gaudet, Mia M., primary, Giles, Graham G., primary, Gram, Inger T., primary, Harris, Holly R., primary, Bolton, Judith Hoffman, primary, Idahl, Annika, primary, Jones, Michael E., primary, Kaaks, Rudolf, primary, Kirsh, Victoria A., primary, Knutsen, Synnove F., primary, Kvaskoff, Marina, primary, Lacey, James V., primary, Lee, I-Min, primary, Milne, Roger L., primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Riboli, Elio, primary, Robien, Kim, primary, Rohan, Thomas E., primary, Sandler, Dale P., primary, Schairer, Catherine, primary, Schouten, Leo J., primary, Setiawan, Veronica W., primary, Swerdlow, Anthony J., primary, Travis, Ruth C., primary, Trichopoulou, Antonia, primary, van den Brandt, Piet A., primary, Visvanathan, Kala, primary, Wilkens, Lynne R., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, and Wentzensen, Nicolas, primary
Published: 2023
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8. Supplementary Table 2 from The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author: Trabert, Britton, primary, Tworoger, Shelley S., primary, O'Brien, Katie M., primary, Townsend, Mary K., primary, Fortner, Renée T., primary, Iversen, Edwin S., primary, Hartge, Patricia, primary, White, Emily, primary, Amiano, Pilar, primary, Arslan, Alan A., primary, Bernstein, Leslie, primary, Brinton, Louise A., primary, Buring, Julie E., primary, Dossus, Laure, primary, Fraser, Gary E., primary, Gaudet, Mia M., primary, Giles, Graham G., primary, Gram, Inger T., primary, Harris, Holly R., primary, Bolton, Judith Hoffman, primary, Idahl, Annika, primary, Jones, Michael E., primary, Kaaks, Rudolf, primary, Kirsh, Victoria A., primary, Knutsen, Synnove F., primary, Kvaskoff, Marina, primary, Lacey, James V., primary, Lee, I-Min, primary, Milne, Roger L., primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Riboli, Elio, primary, Robien, Kim, primary, Rohan, Thomas E., primary, Sandler, Dale P., primary, Schairer, Catherine, primary, Schouten, Leo J., primary, Setiawan, Veronica W., primary, Swerdlow, Anthony J., primary, Travis, Ruth C., primary, Trichopoulou, Antonia, primary, van den Brandt, Piet A., primary, Visvanathan, Kala, primary, Wilkens, Lynne R., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, and Wentzensen, Nicolas, primary
Published: 2023
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9. Supplemental tables 1 and 2 from Inflammatory Markers and Risk of Epithelial Ovarian Cancer by Tumor Subtypes: The EPIC Cohort

Author: Ose, Jennifer, primary, Schock, Helena, primary, Tjønneland, Anne, primary, Hansen, Louise, primary, Overvad, Kim, primary, Dossus, Laure, primary, Clavel-Chapelon, Françoise, primary, Baglietto, Laura, primary, Boeing, Heiner, primary, Trichopolou, Antonia, primary, Benetou, Vassiliki, primary, Lagiou, Pagona, primary, Masala, Giovanna, primary, Tagliabue, Giovanna, primary, Tumino, Rosario, primary, Sacerdote, Carlotta, primary, Mattiello, Amalia, primary, Bueno-de-Mesquita, H. B(as)., primary, Peeters, Petra H. M., primary, Onland-Moret, N. Charlotte, primary, Weiderpass, Elisabete, primary, Gram, Inger T., primary, Sánchez, Soledad, primary, Obon-Santacana, Mireia, primary, Sànchez-Pérez, Maria-José, primary, Larrañaga, Nerea, primary, Castaño, José María Huerta, primary, Ardanaz, Eva, primary, Brändstedt, Jenny, primary, Lundin, Eva, primary, Idahl, Annika, primary, Travis, Ruth C., primary, Khaw, Kay-Tee, primary, Rinaldi, Sabina, primary, Romieu, Isabelle, primary, Merritt, Melissa A., primary, Gunter, Marc J., primary, Riboli, Elio, primary, Kaaks, Rudolf, primary, and Fortner, Renée T., primary
Published: 2023
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10. Data from The Premenopausal Breast Cancer Collaboration: A Pooling Project of Studies Participating in the National Cancer Institute Cohort Consortium

Author: Nichols, Hazel B., primary, Schoemaker, Minouk J., primary, Wright, Lauren B., primary, McGowan, Craig, primary, Brook, Mark N., primary, McClain, Kathleen M., primary, Jones, Michael E., primary, Adami, Hans-Olov, primary, Agnoli, Claudia, primary, Baglietto, Laura, primary, Bernstein, Leslie, primary, Bertrand, Kimberly A., primary, Blot, William J., primary, Boutron-Ruault, Marie-Christine, primary, Butler, Lesley, primary, Chen, Yu, primary, Doody, Michele M., primary, Dossus, Laure, primary, Eliassen, A. Heather, primary, Giles, Graham G., primary, Gram, Inger T., primary, Hankinson, Susan E., primary, Hoffman-Bolton, Judy, primary, Kaaks, Rudolf, primary, Key, Timothy J., primary, Kirsh, Victoria A., primary, Kitahara, Cari M., primary, Koh, Woon-Puay, primary, Larsson, Susanna C., primary, Lund, Eiliv, primary, Ma, Huiyan, primary, Merritt, Melissa A., primary, Milne, Roger L., primary, Navarro, Carmen, primary, Overvad, Kim, primary, Ozasa, Kotaro, primary, Palmer, Julie R., primary, Peeters, Petra H., primary, Riboli, Elio, primary, Rohan, Thomas E., primary, Sadakane, Atsuko, primary, Sund, Malin, primary, Tamimi, Rulla M., primary, Trichopoulou, Antonia, primary, Vatten, Lars, primary, Visvanathan, Kala, primary, Weiderpass, Elisabete, primary, Willett, Walter C., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, Zheng, Wei, primary, Sandler, Dale P., primary, and Swerdlow, Anthony J., primary
Published: 2023
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11. Supplemental Material and Methods, Tables S1-S6, Figure S1 from Investigation of Dietary Factors and Endometrial Cancer Risk Using a Nutrient-wide Association Study Approach in the EPIC and Nurses' Health Study (NHS) and NHSII

Author: Merritt, Melissa A., primary, Tzoulaki, Ioanna, primary, Tworoger, Shelley S., primary, De Vivo, Immaculata, primary, Hankinson, Susan E., primary, Fernandes, Judy, primary, Tsilidis, Konstantinos K., primary, Weiderpass, Elisabete, primary, Tjønneland, Anne, primary, Petersen, Kristina E.N., primary, Dahm, Christina C., primary, Overvad, Kim, primary, Dossus, Laure, primary, Boutron-Ruault, Marie-Christine, primary, Fagherazzi, Guy, primary, Fortner, Renée T., primary, Kaaks, Rudolf, primary, Aleksandrova, Krasimira, primary, Boeing, Heiner, primary, Trichopoulou, Antonia, primary, Bamia, Christina, primary, Trichopoulos, Dimitrios, primary, Palli, Domenico, primary, Grioni, Sara, primary, Tumino, Rosario, primary, Sacerdote, Carlotta, primary, Mattiello, Amalia, primary, Bueno-de-Mesquita, H.B(as)., primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H., primary, Gram, Inger T., primary, Skeie, Guri, primary, Quirós, J. Ramón, primary, Duell, Eric J., primary, Sánchez, María-José, primary, Salmerón, D., primary, Barricarte, Aurelio, primary, Chamosa, Saioa, primary, Ericson, Ulrica, primary, Sonestedt, Emily, primary, Nilsson, Lena Maria, primary, Idahl, Annika, primary, Khaw, Kay-Tee, primary, Wareham, Nicholas, primary, Travis, Ruth C., primary, Rinaldi, Sabina, primary, Romieu, Isabelle, primary, Patel, Chirag J., primary, Riboli, Elio, primary, and Gunter, Marc J., primary
Published: 2023
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12. Table S1 from The Premenopausal Breast Cancer Collaboration: A Pooling Project of Studies Participating in the National Cancer Institute Cohort Consortium

Author: Nichols, Hazel B., primary, Schoemaker, Minouk J., primary, Wright, Lauren B., primary, McGowan, Craig, primary, Brook, Mark N., primary, McClain, Kathleen M., primary, Jones, Michael E., primary, Adami, Hans-Olov, primary, Agnoli, Claudia, primary, Baglietto, Laura, primary, Bernstein, Leslie, primary, Bertrand, Kimberly A., primary, Blot, William J., primary, Boutron-Ruault, Marie-Christine, primary, Butler, Lesley, primary, Chen, Yu, primary, Doody, Michele M., primary, Dossus, Laure, primary, Eliassen, A. Heather, primary, Giles, Graham G., primary, Gram, Inger T., primary, Hankinson, Susan E., primary, Hoffman-Bolton, Judy, primary, Kaaks, Rudolf, primary, Key, Timothy J., primary, Kirsh, Victoria A., primary, Kitahara, Cari M., primary, Koh, Woon-Puay, primary, Larsson, Susanna C., primary, Lund, Eiliv, primary, Ma, Huiyan, primary, Merritt, Melissa A., primary, Milne, Roger L., primary, Navarro, Carmen, primary, Overvad, Kim, primary, Ozasa, Kotaro, primary, Palmer, Julie R., primary, Peeters, Petra H., primary, Riboli, Elio, primary, Rohan, Thomas E., primary, Sadakane, Atsuko, primary, Sund, Malin, primary, Tamimi, Rulla M., primary, Trichopoulou, Antonia, primary, Vatten, Lars, primary, Visvanathan, Kala, primary, Weiderpass, Elisabete, primary, Willett, Walter C., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, Zheng, Wei, primary, Sandler, Dale P., primary, and Swerdlow, Anthony J., primary
Published: 2023
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13. Supplementary Material (Table S1-S3, Figure S1-S2) from High Levels of C-Reactive Protein Are Associated with an Increased Risk of Ovarian Cancer: Results from the Ovarian Cancer Cohort Consortium

Author: Peres, Lauren C., primary, Mallen, Adrianne R., primary, Townsend, Mary K., primary, Poole, Elizabeth M., primary, Trabert, Britton, primary, Allen, Naomi E., primary, Arslan, Alan A., primary, Dossus, Laure, primary, Fortner, Renée T., primary, Gram, Inger T., primary, Hartge, Patricia, primary, Idahl, Annika, primary, Kaaks, Rudolf, primary, Kvaskoff, Marina, primary, Magliocco, Anthony M., primary, Merritt, Melissa A., primary, Quirós, J. Ramón, primary, Tjonneland, Anne, primary, Trichopoulou, Antonia, primary, Tumino, Rosario, primary, van Gils, Carla H., primary, Visvanathan, Kala, primary, Wentzensen, Nicolas, primary, Zeleniuch-Jacquotte, Anne, primary, and Tworoger, Shelley S., primary
Published: 2023
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14. Data from High Levels of C-Reactive Protein Are Associated with an Increased Risk of Ovarian Cancer: Results from the Ovarian Cancer Cohort Consortium

Author: Peres, Lauren C., primary, Mallen, Adrianne R., primary, Townsend, Mary K., primary, Poole, Elizabeth M., primary, Trabert, Britton, primary, Allen, Naomi E., primary, Arslan, Alan A., primary, Dossus, Laure, primary, Fortner, Renée T., primary, Gram, Inger T., primary, Hartge, Patricia, primary, Idahl, Annika, primary, Kaaks, Rudolf, primary, Kvaskoff, Marina, primary, Magliocco, Anthony M., primary, Merritt, Melissa A., primary, Quirós, J. Ramón, primary, Tjonneland, Anne, primary, Trichopoulou, Antonia, primary, Tumino, Rosario, primary, van Gils, Carla H., primary, Visvanathan, Kala, primary, Wentzensen, Nicolas, primary, Zeleniuch-Jacquotte, Anne, primary, and Tworoger, Shelley S., primary
Published: 2023
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15. Prediagnostic serum glyceraldehyde-derived advanced glycation end products and mortality among colorectal cancer patients

Author: Mao, Ziling, Baker, Jacqueline Roshelli, Takeuchi, Masayoshi, Hyogo, Hideyuki, Tjønneland, Anne, Eriksen, Anne Kirstine, Severi, Gianluca, Rothwell, Joseph, Laouali, Nasser, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Palli, Domenico, Sieri, Sabina, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Derksen, Jeroen W. G., Gram, Inger T., Skeie, Guri, Sandanger, Torkjel M., Quirós, Jose Ramón, Crous-Bou, Marta, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra M., Guevara, Marcela, Harlid, Sophia, Johansson, Ingegerd, Perez-Cornago, Aurora, Freisling, Heinz, Gunter, Marc, Weiderpass, Elisabete, Heath, Alicia K., Aglago, Elom, Jenab, Mazda, Fedirko, Veronika, Mao, Ziling, Baker, Jacqueline Roshelli, Takeuchi, Masayoshi, Hyogo, Hideyuki, Tjønneland, Anne, Eriksen, Anne Kirstine, Severi, Gianluca, Rothwell, Joseph, Laouali, Nasser, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Palli, Domenico, Sieri, Sabina, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Derksen, Jeroen W. G., Gram, Inger T., Skeie, Guri, Sandanger, Torkjel M., Quirós, Jose Ramón, Crous-Bou, Marta, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra M., Guevara, Marcela, Harlid, Sophia, Johansson, Ingegerd, Perez-Cornago, Aurora, Freisling, Heinz, Gunter, Marc, Weiderpass, Elisabete, Heath, Alicia K., Aglago, Elom, Jenab, Mazda, and Fedirko, Veronika
Abstract: Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) could contribute to colorectal cancer development and progression due to their pro-oxidative and pro-inflammatory properties. However, the association of glycer-AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer-AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer-AGEs concentrations with CRC-specific and all-cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow-up, 529 participants died (409 from CRC). Glycer-AGEs were statistically significantly positively associated with CRC-specific (HRQ5 vs Q1 = 1.53, 95% CI: 1.04-2.25, Ptrend =.002) and all-cause (HRQ5 vs Q1 = 1.62, 95% CI: 1.16-2.26, Ptrend <.001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer-AGEs and CRC-specific mortality among patients with distal colon cancer (per SD increment: HRproximal colon = 1.02, 95% CI: 0.74-1.42; HRdistal colon = 1.51, 95% CI: 1.20-1.91; Peffect modification =.02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer-AGEs category relative to lowest BMI and glycer-AGEs category for both CRC-specific (HR = 1.78, 95% CI: 1.02-3.01) and all-cause mortality (HR = 2.15, 95% CI: 1.33-3.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer-AGEs are positively associated with CRC-specific and all-cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted.
Published: 2023
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16. An epidemiological model for prediction of endometrial cancer risk in Europe

Author: Hüsing, Anika, Dossus, Laure, Ferrari, Pietro, Tjønneland, Anne, Hansen, Louise, Fagherazzi, Guy, Baglietto, Laura, Schock, Helena, Chang-Claude, Jenny, Boeing, Heiner, Steffen, Annika, Trichopoulou, Antonia, Bamia, Christina, Katsoulis, Michalis, Krogh, Vittorio, Palli, Domenico, Panico, Salvatore, Onland-Moret, N. Charlotte, Peeters, Petra H., Bueno-de-Mesquita, H. Bas, Weiderpass, Elisabete, Gram, Inger T., Ardanaz, Eva, Obón-Santacana, Mireia, Navarro, Carmen, Sánchez-Cantalejo, Emilio, Etxezarreta, Nerea, Allen, Naomi E., Khaw, Kay Tee, Wareham, Nick, Rinaldi, Sabina, Romieu, Isabelle, Merritt, Melissa A., Gunter, Marc, Riboli, Elio, and Kaaks, Rudolf
Published: 2016

17. Development and validation of circulating CA125 prediction models in postmenopausal women

Author: Sasamoto, Naoko, Babic, Ana, Rosner, Bernard A., Fortner, Renée T., Vitonis, Allison F., Yamamoto, Hidemi, Fichorova, Raina N., Titus, Linda J., Tjønneland, Anne, Hansen, Louise, Kvaskoff, Marina, Fournier, Agnès, Mancini, Francesca Romana, Boeing, Heiner, Trichopoulou, Antonia, Peppa, Eleni, Karakatsani, Anna, Palli, Domenico, Grioni, Sara, Mattiello, Amalia, Tumino, Rosario, Fiano, Valentina, Onland-Moret, N. Charlotte, Weiderpass, Elisabete, Gram, Inger T., Quirós, J. Ramón, Lujan-Barroso, Leila, Sánchez, Maria-Jose, Colorado-Yohar, Sandra, Barricarte, Aurelio, Amiano, Pilar, Idahl, Annika, Lundin, Eva, Sartor, Hanna, Khaw, Kay-Tee, Key, Timothy J., Muller, David, Riboli, Elio, Gunter, Marc, Dossus, Laure, Trabert, Britton, Wentzensen, Nicolas, Kaaks, Rudolf, Cramer, Daniel W., Tworoger, Shelley S., and Terry, Kathryn L.
Published: 2019
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18. Pre‐diagnostic Serum Glyceraldehyde‐Derived Advanced Glycation End Products and Mortality Among Colorectal Cancer Patients

Author: Mao, Ziling, primary, Baker, Jacqueline Roshelli, additional, Takeuchi, Masayoshi, additional, Hyogo, Hideyuki, additional, Tjønneland, Anne, additional, Eriksen, Anne Kirstine, additional, Severi, Gianluca, additional, Rothwell, Joseph, additional, Laouali, Nasser, additional, Katzke, Verena, additional, Kaaks, Rudolf, additional, Schulze, Matthias B., additional, Palli, Domenico, additional, Sieri, Sabina, additional, de Magistris, Maria Santucci, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Derksen, Jeroen W.G., additional, Gram, Inger T., additional, Skeie, Guri, additional, Sandanger, Torkjel M., additional, Quirós, Jose Ramón, additional, Crous‐Bou, Marta, additional, Sánchez, Maria‐Jose, additional, Amiano, Pilar, additional, Colorado‐Yohar, Sandra M., additional, Guevara, Marcela, additional, Harlid, Sophia, additional, Johansson, Ingegerd, additional, Perez‐Cornago, Aurora, additional, Freisling, Heinz, additional, Gunter, Marc, additional, Weiderpass, Elisabete, additional, Heath, Alicia K., additional, Aglago, Elom, additional, Jenab, Mazda, additional, and Fedirko, Veronika, additional
Published: 2023
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19. Smoking and pancreatic cancer: a sex-specific analysis in the Multiethnic Cohort study

Author: Gram, Inger T., primary, Park, Song-Yi, additional, Wilkens, Lynne R., additional, Le Marchand, Loïc, additional, and Setiawan, Veronica Wendy, additional
Published: 2022
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20. Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses

Author: Dimou, Niki, primary, Omiyale, Wemimo, additional, Biessy, Carine, additional, Viallon, Vivian, additional, Kaaks, Rudolf, additional, O'Mara, Tracy A., additional, Aglago, Elom K., additional, Ardanaz, Eva, additional, Bergmann, Manuela M., additional, Bondonno, Nicola P., additional, Braaten, Tonje, additional, Colorado-Yohar, Sandra M., additional, Crous-Bou, Marta, additional, Dahm, Christina C., additional, Fortner, Renée T., additional, Gram, Inger T., additional, Harlid, Sophia, additional, Heath, Alicia K., additional, Idahl, Annika, additional, Kvaskoff, Marina, additional, Nøst, Therese H., additional, Overvad, Kim, additional, Palli, Domenico, additional, Perez-Cornago, Aurora, additional, Sacerdote, Carlotta, additional, Sánchez, Maria-Jose, additional, Schulze, Matthias B., additional, Severi, Gianluca, additional, Simeon, Vittorio, additional, Tagliabue, Giovanna, additional, Tjønneland, Anne, additional, Truong, Thérèse, additional, Tumino, Rosario, additional, Johansson, Mattias, additional, Weiderpass, Elisabete, additional, Murphy, Neil, additional, Gunter, Marc J., additional, Lacey, Ben, additional, Allen, Naomi E., additional, and Dossus, Laure, additional
Published: 2022
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21. Cigarette Smoking and Endometrial Cancer Risk : observational and Mendelian Randomization Analyses

Author: Dimou, Niki, Omiyale, Wemimo, Biessy, Carine, Viallon, Vivian, Kaaks, Rudolf, O'Mara, Tracy A., Aglago, Elom K., Ardanaz, Eva, Bergmann, Manuela M., Bondonno, Nicola P., Braaten, Tonje, Colorado-Yohar, Sandra M., Crous-Bou, Marta, Dahm, Christina C., Fortner, Renée T, Gram, Inger T., Harlid, Sophia, Heath, Alicia K., Idahl, Annika, Kvaskoff, Marina, Nøst, Therese H., Overvad, Kim, Palli, Domenico, Perez-Cornago, Aurora, Sacerdote, Carlotta, Sánchez, Maria-Jose, Schulze, Matthias B., Severi, Gianluca, Simeon, Vittorio, Tagliabue, Giovanna, Tjønneland, Anne, Truong, Thérèse, Tumino, Rosario, Johansson, Mattias, Weiderpass, Elisabete, Murphy, Neil, Gunter, Marc J., Lacey, Ben, Allen, Naomi E., Dossus, Laure, Dimou, Niki, Omiyale, Wemimo, Biessy, Carine, Viallon, Vivian, Kaaks, Rudolf, O'Mara, Tracy A., Aglago, Elom K., Ardanaz, Eva, Bergmann, Manuela M., Bondonno, Nicola P., Braaten, Tonje, Colorado-Yohar, Sandra M., Crous-Bou, Marta, Dahm, Christina C., Fortner, Renée T, Gram, Inger T., Harlid, Sophia, Heath, Alicia K., Idahl, Annika, Kvaskoff, Marina, Nøst, Therese H., Overvad, Kim, Palli, Domenico, Perez-Cornago, Aurora, Sacerdote, Carlotta, Sánchez, Maria-Jose, Schulze, Matthias B., Severi, Gianluca, Simeon, Vittorio, Tagliabue, Giovanna, Tjønneland, Anne, Truong, Thérèse, Tumino, Rosario, Johansson, Mattias, Weiderpass, Elisabete, Murphy, Neil, Gunter, Marc J., Lacey, Ben, Allen, Naomi E., and Dossus, Laure
Abstract: BACKGROUND: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses. METHODS: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In two-sample MR analyses, genetic variants robustly associated with lifetime amount of smoking (n = 126 variants) and ever having smoked regularly (n = 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined. RESULTS: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91-1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer. CONCLUSIONS: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer. IMPACT: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk.
Published: 2022
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22. Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author: Ellingjord-Dale, Merete, Christakoudi, Sofia, Weiderpass, Elisabete, Panico, Salvatore, Dossus, Laure, Olsen, Anja, Tjønneland, Anne, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Gram, Inger T., Skeie, Guri, Rosendahl, Ann H., Sund, Malin, Key, Tim, Ferrari, Pietro, Gunter, Marc, Heath, Alicia K., Tsilidis, Konstantinos K., Riboli, Elio, Ellingjord-Dale, Merete, Christakoudi, Sofia, Weiderpass, Elisabete, Panico, Salvatore, Dossus, Laure, Olsen, Anja, Tjønneland, Anne, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Gram, Inger T., Skeie, Guri, Rosendahl, Ann H., Sund, Malin, Key, Tim, Ferrari, Pietro, Gunter, Marc, Heath, Alicia K., Tsilidis, Konstantinos K., and Riboli, Elio
Abstract: BACKGROUND: The role of obesity and weight change in breast-cancer development is complex and incompletely understood. We investigated long-term weight change and breast-cancer risk by body mass index (BMI) at age 20 years, menopausal status, hormone replacement therapy (HRT) and hormone-receptor status. METHODS: Using data on weight collected at three different time points from women who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the association between weight change from age 20 years until middle adulthood and risk of breast cancer. RESULTS: In total, 150 257 women with a median age of 51 years at cohort entry were followed for an average of 14 years (standard deviation = 3.9) during which 6532 breast-cancer cases occurred. Compared with women with stable weight (±2.5 kg), long-term weight gain >10 kg was positively associated with postmenopausal breast-cancer risk in women who were lean at age 20 [hazard ratio (HR) = 1.42; 95% confidence interval 1.22-1.65] in ever HRT users (HR = 1.23; 1.04-1.44), in never HRT users (HR = 1.40; 1.16-1.68) and in oestrogen-and-progesterone-receptor-positive (ER+PR+) breast cancer (HR = 1.46; 1.15-1.85). CONCLUSION: Long-term weight gain was positively associated with postmenopausal breast cancer in women who were lean at age 20, both in HRT ever users and non-users, and hormone-receptor-positive breast cancer.
Published: 2022
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23. Cigarette Smoking and Endometrial Cancer Risk:Observational and Mendelian Randomization Analyses

Author: Dimou, Niki, Omiyale, Wemimo, Biessy, Carine, Viallon, Vivian, Kaaks, Rudolf, O'Mara, Tracy A., Aglago, Elom K., Ardanaz, Eva, Bergmann, Manuela M., Bondonno, Nicola P., Braaten, Tonje, Colorado-Yohar, Sandra M., Crous-Bou, Marta, Dahm, Christina C., Fortner, Renee T., Gram, Inger T., Harlid, Sophia, Heath, Alicia K., Idahl, Annika, Kvaskoff, Marina, Nost, Therese H., Overvad, Kim, Palli, Domenico, Perez-Cornago, Aurora, Sacerdote, Carlotta, Sanchez, Maria-Jose, Schulze, Matthias B., Severi, Gianluca, Simeon, Vittorio, Tagliabue, Giovanna, Tjonneland, Anne, Truong, Therese, Tumino, Rosario, Johansson, Mattias, Weiderpass, Elisabete, Murphy, Neil, Gunter, Marc J., Lacey, Ben, Allen, Naomi E., Dossus, Laure, Dimou, Niki, Omiyale, Wemimo, Biessy, Carine, Viallon, Vivian, Kaaks, Rudolf, O'Mara, Tracy A., Aglago, Elom K., Ardanaz, Eva, Bergmann, Manuela M., Bondonno, Nicola P., Braaten, Tonje, Colorado-Yohar, Sandra M., Crous-Bou, Marta, Dahm, Christina C., Fortner, Renee T., Gram, Inger T., Harlid, Sophia, Heath, Alicia K., Idahl, Annika, Kvaskoff, Marina, Nost, Therese H., Overvad, Kim, Palli, Domenico, Perez-Cornago, Aurora, Sacerdote, Carlotta, Sanchez, Maria-Jose, Schulze, Matthias B., Severi, Gianluca, Simeon, Vittorio, Tagliabue, Giovanna, Tjonneland, Anne, Truong, Therese, Tumino, Rosario, Johansson, Mattias, Weiderpass, Elisabete, Murphy, Neil, Gunter, Marc J., Lacey, Ben, Allen, Naomi E., and Dossus, Laure
Abstract: Background: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. How-ever, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses. Methods: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In two-sample MR analyses, genetic variants robustly associated with lifetime amount of smoking (n = 126 variants) and ever having smoked regularly (n = 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined. Results: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91-1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer. Conclusions: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer. Impact: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk.
Published: 2022

24. Endometrial cancer risk prediction including serum‐based biomarkers: results from the EPIC cohort

Author: Fortner, Renée T., Hüsing, Anika, Kühn, Tilman, Konar, Meric, Overvad, Kim, Tjønneland, Anne, Hansen, Louise, BoutronRuault, MarieChristine, Severi, Gianluca, Fournier, Agnès, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vasiliki, Orfanos, Philippos, Masala, Giovanna, Agnoli, Claudia, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, BuenodeMesquita, H.B(as), Peeters, Petra H.M., Weiderpass, Elisabete, Gram, Inger T., Gavrilyuk, Oxana, Quirós, J. Ramón, Maria Huerta, José, Ardanaz, Eva, Larrañaga, Nerea, LujanBarroso, Leila, SánchezCantalejo, Emilio, Butt, Salma Tunå, Borgquist, Signe, Idahl, Annika, Lundin, Eva, Khaw, KayTee, Allen, Naomi E., Rinaldi, Sabina, Dossus, Laure, Gunter, Marc, Merritt, Melissa A., Tzoulaki, Ioanna, Riboli, Elio, and Kaaks, Rudolf
Published: 2017
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25. Additional file 1 of Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort

Author: Cairat, Manon, Rinaldi, Sabina, Navionis, Anne-Sophie, Romieu, Isabelle, Biessy, Carine, Viallon, Vivian, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Severi, Gianluca, Kvaskoff, Marina, Fortner, Renée T., Kaaks, Rudolf, Aleksandrova, Krasimira, Schulze, Matthias B., Masala, Giovanna, Tumino, Rosario, Sieri, Sabina, Grasso, Chiara, Mattiello, Amalia, Gram, Inger T., Olsen, Karina Standahl, Agudo, Antonio, Etxezarreta, Pilar Amiano, Sánchez, Maria-Jose, Santiuste, Carmen, Barricarte, Aurelio, Monninkhof, Evelyn, Hiensch, Anouk E., Muller, David, Merritt, Melissa A., Travis, Ruth C., Weiderpass, Elisabete, Gunter, Marc J., and Dossus, Laure
Subjects: skin and connective tissue diseases
Abstract: Additional file 1: Circulating inflammatory biomarkers and breast cancer risk in the EPIC prospective study: Supplementary Tables S1- S7 and Figures S1-S3. Table S1. Geometric mean values for inflammatory biomarkers in breast cancer cases and matched controls. Table S2. Associations between inflammatory biomarkers and breast cancer risk by age at diagnosis. Table S3. Associations between inflammatory biomarkers and breast cancer risk by breast cancer molecular subtypes. Table S4. Associations between inflammatory biomarkers and breast cancer risk by time between blood collection and diagnosis. Table S5. Associations between inflammatory biomarkers and breast cancer risk by body mass index. Table S6. Associations between inflammatory biomarkers and breast cancer risk by waist circumference. Table S7. Associations between inflammatory biomarkers and breast cancer risk among non-hormone users at blood collection. Table S8. Associations between IL-10 and breast cancer risk overall and according to menopausal status at blood collection, after excluding women with values of IL-10 below the LOQ. Table S9. Associations between TNF-α and breast cancer risk overall and according to menopausal status at blood collection, after excluding women with values of TNF-α below the LOQ. Figure S1. Flow chart of the study population. Figure S2. Association between leptin and breast cancer risk, overall and by menopausal status, allowing for nonlinear effects (restricted cubic spline). Figure S3. Association between leptin-to-adiponectin ratio and breast cancer risk, overall and by menopausal status, allowing for nonlinear effects (restricted cubic spline). Figure S4. Association between CRP with breast cancer risk, overall and by menopausal status, allowing for nonlinear effects (restricted cubic spline).
Published: 2022
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26. Dietary Intake of Advanced Glycation End Products (AGEs) and Mortality among Individuals with Colorectal Cancer

Author: Mao, Ziling, primary, Aglago, Elom K., additional, Zhao, Zhiwei, additional, Schalkwijk, Casper, additional, Jiao, Li, additional, Freisling, Heinz, additional, Weiderpass, Elisabete, additional, Hughes, David J., additional, Eriksen, Anne Kirstine, additional, Tjønneland, Anne, additional, Severi, Gianluca, additional, Rothwell, Joseph, additional, Boutron-Ruault, Marie-Christine, additional, Katzke, Verena, additional, Kaaks, Rudolf, additional, Schulze, Matthias B., additional, Birukov, Anna, additional, Krogh, Vittorio, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Bueno-de-Mesquita, H. Bas, additional, Vermeulen, Roel C. H., additional, Gram, Inger T., additional, Skeie, Guri, additional, Sandanger, Torkjel M., additional, Quirós, J. Ramón, additional, Crous-Bou, Marta, additional, Sánchez, Maria-Jose, additional, Amiano, Pilar, additional, Chirlaque, María-Dolores, additional, Barricarte Gurrea, Aurelio, additional, Manjer, Jonas, additional, Johansson, Ingegerd, additional, Perez-Cornago, Aurora, additional, Jenab, Mazda, additional, and Fedirko, Veronika, additional
Published: 2021
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27. Smoking and Risk of Breast Cancer in a Racially/Ethnically Diverse Population of Mainly Women Who Do Not Drink Alcohol: The MEC Study

Author: Gram, Inger T., Park, Song-Yi, Kolonel, Laurence N., Maskarinec, Gertraud, Wilkens, Lynne R., Henderson, Brian E., and Le Marchand, Loïc
Published: 2015
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28. Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteristics in the European Prospective Investigation into Cancer and Nutrition

Author: Ose, Jennifer, Fortner, Renée T., Rinaldi, Sabina, Schock, Helena, Overvad, Kim, Tjonneland, Anne, Hansen, Louise, Dossus, Laure, Fournier, Agnes, Baglietto, Laura, Romieu, Isabelle, Kuhn, Elisabetta, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Quiros, Jose Ramon, Obón-Santacana, Mireia, Larrañaga, Nerea, Chirlaque, María-Dolores, Sánchez, María-José, Barricarte, Aurelio, Peeters, Petra H., Bueno-de-Mesquita, H. B(as), Onland-Moret, Charlotte N., Brändstedt, Jenny, Lundin, Eva, Idahl, Annika, Weiderpass, Elisabete, Gram, Inger T., Lund, Eiliv, Kaw, Kay-Tee, Travis, Ruth C., Merritt, Melissa A., Gunther, Marc J., Riboli, Elio, and Kaaks, Rudolf
Published: 2015
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29. Factors associated with predictors of smoking cessation from a Norwegian internet-based smoking cessation intervention study.

Author: Gram, Inger T., Antypas, Konstantinos, Wangberg, Silje C., Løchen, Maja-Lisa, and Larbi, Dillys
Subjects: SMOKING cessation, NORWEGIANS, PUBLIC health, QUESTIONNAIRES, INFORMATION retrieval
Abstract: INTRODUCTION We examined if we could identify predictors for smoking cessation at six months post cessation, among smokers enrolled in a large Norwegian populationbased intervention study. METHODS We followed 4333 (72.1% women) smokers who enrolled in an internetbased smoking cessation intervention during 2010-2012. The baseline questionnaire collected information on sociodemographic and lifestyle factors, including current snus use. The cessation outcome was self-reported no smoking past seven days, at six months. We used logistic regression to estimate odds ratios (ORs) with 95% confidence intervals, to identify predictors of smoking cessation, adjusting for potential confounders. RESULTS Women (OR=1.30; 95% CI: 1.01-1.69) compared with men, and those with medium (OR=1.31; 95% CI: 1.02-1.68) and longer (OR=1.42; 95% CI: 1.06-1.90) education compared with those with shorter education, were more likely to be successful quitters. Overall, being a student (OR=0.56; 95% CI: 0.37-0.85) compared with having fulltime work, and a moderate to high Fagerström test for nicotine dependence (FTND) score (OR=0.69; 95% CI: 0.55-0.87) compared with a low score, were predictors for unsuccessful cessation. Current snus use was a predictor for unsuccessful cessation compared to no snus use for both men (OR=0.49; 95% CI: 0.28-0.88) and women (OR=0.49; 95% CI: 0.32-0.75). CONCLUSIONS Our study identifies female sex and longer education as predictors for successful smoking cessation, while a medium or high FTND score, being a student, and current snus use, were predictors for unsuccessful smoking cessation. Only current snus use was a predictor for unsuccessful cessation for both sexes. Our results indicate that smokers should be warned that snus use may prevent successful smoking cessation. [ABSTRACT FROM AUTHOR]
Published: 2022
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30. Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Author: Londoño, Catalina, primary, Cayssials, Valerie, additional, de Villasante, Izar, additional, Crous-Bou, Marta, additional, Scalbert, Augustin, additional, Weiderpass, Elisabete, additional, Agudo, Antonio, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Katzke, Verena, additional, Schulze, Matthias, additional, Palli, Domenico, additional, Krogh, Vittorio, additional, Santucci de Magistris, Maria, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Gram, Inger T., additional, Rylander, Charlotta, additional, Skeie, Guri, additional, Sánchez, Maria-Jose, additional, Amiano, Pilar, additional, Huerta, José María, additional, Barricarte, Aurelio, additional, Sartor, Hanna, additional, Sonestedt, Emily, additional, Esberg, Anders, additional, Idahl, Annika, additional, Mahamat-Saleh, Yahya, additional, Laouali, Nasser, additional, Kvaskoff, Marina, additional, Turzanski-Fortner, Renée, additional, and Zamora-Ros, Raul, additional
Published: 2021
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31. Never-smokers and the fraction of breast cancer attributable to second-hand smoke from parents during childhood: the Norwegian Women and Cancer Study 1991–2018

Author: Gram, Inger T, primary, Wiik, Arne Bastian, additional, Lund, Eiliv, additional, Licaj, Idlir, additional, and Braaten, Tonje, additional
Published: 2021
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32. Inflammatory potential of the diet and risk of breast cancer in the European Investigation into Cancer and Nutrition (EPIC) study

Author: Castro-Espin, Carlota, primary, Agudo, Antonio, additional, Bonet, Catalina, additional, Katzke, Verena, additional, Turzanski-Fortner, Renée, additional, Aleksandrova, Krasimira, additional, Schulze, Matthias B., additional, Tjønneland, Anne, additional, Dahm, Christina C., additional, Quirós, José-Ramón, additional, Sánchez, María-José, additional, Amiano, Pilar, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Masala, Giovanna, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Panico, Salvatore, additional, May, Anne M., additional, Bodén, Stina, additional, Gram, Inger T., additional, Skeie, Guri, additional, Laouali, Nasser, additional, Shah, Sanam, additional, Severi, Gianluca, additional, Aune, Dagfinn, additional, Merritt, Melissa A., additional, Cairat, Manon, additional, Weiderpass, Elisabete, additional, Riboli, Elio, additional, Dossus, Laure, additional, and Jakszyn, Paula, additional
Published: 2021
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33. Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author: Ellingjord-Dale, Merete, Christakoudi, Sofia, Weiderpass, Elisabete, Panico, Salvatore, Dossus, Laure, Olsen, Anja, Tjonneland, Anne, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Gram, Inger T., Skeie, Guri, Rosendahl, Ann H., Sund, Malin, Key, Tim, Ferrari, Pietro, Gunter, Marc, Heath, Alicia K., Tsilidis, Konstantinos K., Riboli, Elio, Jose Sanchez, Maria, Chirlaque Lopez, Maria Dolores, Peppa, Eleni, Trichopoulou, Antonia, Martimianaki, Georgia, Agudo, Antonio, Santiuste, Carmen, Ardanaz, Eva, Amiano, Pilar, Boutron-Ruault, Marie-Christine, Simeon, Vittorio, Berrino, Franco, Tumino, Rosario, Severi, Gianluca, Stocks, Tanja, Turzanski-Fortner, Renee, Aleksandrova, Krasimira, Rylander, Charlotta, Aune, Dagfinn, Dahm, Christina C., Department of Surgery, and HUS Abdominal Center
Subjects: 0301 basic medicine, Epidemiology, medicine.medical_treatment, Weight Gain, Body Mass Index, 0302 clinical medicine, Risk Factors, Prospective Studies, skin and connective tissue diseases, Public, Environmental & Occupational Health, 2. Zero hunger, Obstetrics, Hazard ratio, 0104 Statistics, Hormone replacement therapy (menopause), General Medicine, Middle Aged, EARLY ADULTHOOD, 3142 Public health care science, environmental and occupational health, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Additional Authors, long-term weight change, POSTMENOPAUSAL WOMEN, 030220 oncology & carcinogenesis, OBESITY, Obesitat, Female, medicine.symptom, Life Sciences & Biomedicine, Cohort study, Adult, medicine.medical_specialty, MENOPAUSE, Breast Neoplasms, SEX STEROIDS, Càncer de mama, 1117 Public Health and Health Services, Young Adult, 03 medical and health sciences, Breast cancer, breast cancer, BODY FATNESS, medicine, cohort study, Humans, AcademicSubjects/MED00860, VALIDITY, Science & Technology, OVERWEIGHT, business.industry, Kirurgi, Weight change, ANTHROPOMETRIC MEASURES, medicine.disease, 030104 developmental biology, Surgery, GAIN, business, Weight gain, Body mass index
Abstract: The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by the Danish Cancer Society (Kræftens Bekæmpelse) (Denmark), German Cancer Aid (Deutsche Krebshilfe), German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Federal Ministry of Education and Research (Bundesministerium fu¨ r Bildung und Forschung, BMBF) (Germany), Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy), Swedish Cancer Society (Cancerfonden), Swedish Research Council (Vetenskapsra° det), County Councils of Ska°ne and Va¨sterbotten (Sweden), Cancer Research UK (14136 to EPIC-Norfolk; C570/ A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk; MR/M012190/1 to EPICOxford) (UK). Infrastructure support for the Department of Epidemiology and Biostatistics at Imperial College London (UK) was provided by the NIHR Imperial Biomedical Research Centre (BRC). The funders had no role in the design and conduct of the study; the collection, analysis and interpretation of the data; or the preparation, review and approval of the manuscript; or in the decision to submit the manuscript for publication., Background: The role of obesity and weight change in breast-cancer development is complex and incompletely understood. We investigated long-term weight change and breast-cancer risk by body mass index (BMI) at age 20 years, menopausal status, hormone replacement therapy (HRT) and hormone-receptor status. Methods: Using data on weight collected at three different time points from women who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the association between weight change from age 20 years until middle adulthood and risk of breast cancer. Results: In total, 150 257 women with a median age of 51 years at cohort entry were followed for an average of 14 years (standard deviation¼3.9) during which 6532 breast-cancer cases occurred. Compared with women with stable weight (62.5 kg), long-term weight gain >10 kg was positively associated with postmenopausal breast-cancer risk in women who were lean at age 20 [hazard ratio (HR)¼1.42; 95% confidence interval 1.22–1.65] in ever HRT users (HR¼1.23; 1.04–1.44), in never HRT users (HR¼1.40; 1.16–1.68) and in oestrogen-and-progesterone-receptor-positive (ERþPRþ) breast cancer (HR¼1.46; 1.15–1.85). Conclusion: Long-term weight gain was positively associated with postmenopausal breast cancer in women who were lean at age 20, both in HRT ever users and non-users, and hormone-receptor-positive breast cancer., European Commission (DG-SANCO), International Agency for Research on Cancer, Danish Cancer Society (Kraftens Bekampelse), German Cancer Aid, German Cancer Research Center, Federal Ministry of Education and Research, Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council, Swedish Cancer Society, Swedish Research Council, County Councils of Skane and Vasterbotten, 14136 Cancer Research UK, C570/A16491 EPIC-Norfolk, 1000143 Medical Research Council, Infrastructure support for the Department of Epidemiology and Biostatistics at Imperial College London (UK) was provided by the NIHR Imperial Biomedical Research Centre (BRC)
Published: 2021

34. Soluble Receptor for Advanced Glycation End-products (sRAGE) and Colorectal Cancer Risk : A Case-Control Study Nested within a European Prospective Cohort

Author: Aglago, Elom K., Rinaldi, Sabina, Freisling, Heinz, Jiao, Li, Hughes, David J., Fedirko, Veronika, Schalkwijk, Casper G., Weiderpass, Elisabete, Dahm, Christina C., Overvad, Kim, Eriksen, Anne Kirstine, Kyrø, Cecilie, Boutron-Ruault, Marie-Christine, Rothwell, Joseph A., Severi, Gianluca, Katzke, Verena, Kühn, Tilman, Schulze, Matthias B., Aleksandrova, Krasimira, Masala, Giovanna, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Naccarati, Alessio, Bueno-de-Mesquita, Bas, van Gils, Carla H., Sandanger, Torkjel M., Gram, Inger T., Skeie, Guri, Quirós, J. Ramón, Jakszyn, Paula, Sánchez, Maria-Jose, Amiano, Pilar, Huerta, José María, Ardanaz, Eva, Johansson, Ingegerd, Harlid, Sophia, Perez-Cornago, Aurora, Mayén, Ana-Lucia, Cordova, Reynalda, Gunter, Marc J., Vineis, Paolo, Cross, Amanda J., Riboli, Elio, Jenab, Mazda, Aglago, Elom K., Rinaldi, Sabina, Freisling, Heinz, Jiao, Li, Hughes, David J., Fedirko, Veronika, Schalkwijk, Casper G., Weiderpass, Elisabete, Dahm, Christina C., Overvad, Kim, Eriksen, Anne Kirstine, Kyrø, Cecilie, Boutron-Ruault, Marie-Christine, Rothwell, Joseph A., Severi, Gianluca, Katzke, Verena, Kühn, Tilman, Schulze, Matthias B., Aleksandrova, Krasimira, Masala, Giovanna, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Naccarati, Alessio, Bueno-de-Mesquita, Bas, van Gils, Carla H., Sandanger, Torkjel M., Gram, Inger T., Skeie, Guri, Quirós, J. Ramón, Jakszyn, Paula, Sánchez, Maria-Jose, Amiano, Pilar, Huerta, José María, Ardanaz, Eva, Johansson, Ingegerd, Harlid, Sophia, Perez-Cornago, Aurora, Mayén, Ana-Lucia, Cordova, Reynalda, Gunter, Marc J., Vineis, Paolo, Cross, Amanda J., Riboli, Elio, and Jenab, Mazda
Abstract: BACKGROUND: Overexpression of the receptor for advanced glycation end-product (RAGE) has been associated with chronic inflammation, which in turn has been associated with increased colorectal cancer risk. Soluble RAGE (sRAGE) competes with RAGE to bind its ligands, thus potentially preventing RAGE-induced inflammation. METHODS: To investigate whether sRAGE and related genetic variants are associated with colorectal cancer risk, we conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Plasma sRAGE concentrations were measured by ELISA in 1,361 colorectal cancer matched case-control sets. Twenty-four SNPs encoded in the genes associated with sRAGE concentrations were available for 1,985 colorectal cancer cases and 2,220 controls. Multivariable adjusted ORs and 95% confidence intervals (CIs) were computed using conditional and unconditional logistic regression for colorectal cancer risk and circulating sRAGE and SNPs, respectively. RESULTS: Higher sRAGE concentrations were inversely associated with colorectal cancer (ORQ5vs.Q1, 0.77; 95% CI, 0.59-1.00). Sex-specific analyses revealed that the observed inverse risk association was restricted to men (ORQ5vs.Q1, 0.63; 95% CI, 0.42-0.94), whereas no association was observed in women (ORQ5vs.Q1, 1.00; 95% CI, 0.68-1.48; Pheterogeneity for sex = 0.006). Participants carrying minor allele of rs653765 (promoter region of ADAM10) had lower colorectal cancer risk (C vs. T, OR, 0.90; 95% CI, 0.82-0.99). CONCLUSIONS: Prediagnostic sRAGE concentrations were inversely associated with colorectal cancer risk in men, but not in women. An SNP located within ADAM10 gene, pertaining to RAGE shedding, was associated with colorectal cancer risk. IMPACT: Further studies are needed to confirm our observed sex difference in the association and better explore the potential involvement of genetic variants of sRAGE in colorectal cancer development.
Published: 2021
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35. Dietary intake of advanced glycation end products (Ages) and mortality among individuals with colorectal cancer

Author: Mao, Ziling, Aglago, Elom K., Zhao, Zhiwei, Schalkwijk, Casper, Jiao, Li, Freisling, Heinz, Weiderpass, Elisabete, Hughes, David J., Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Rothwell, Joseph, Boutron-Ruault, Marie-Christine, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Birukov, Anna, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Bueno-De-mesquita, H. Bas, Vermeulen, Roel C. H., Gram, Inger T., Skeie, Guri, Sandanger, Torkjel M., Quirós, J. Ramón, Crous-Bou, Marta, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Gurrea, Aurelio Barricarte, Manjer, Jonas, Johansson, Ingegerd, Perez-Cornago, Aurora, Jenab, Mazda, Fedirko, Veronika, Mao, Ziling, Aglago, Elom K., Zhao, Zhiwei, Schalkwijk, Casper, Jiao, Li, Freisling, Heinz, Weiderpass, Elisabete, Hughes, David J., Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Rothwell, Joseph, Boutron-Ruault, Marie-Christine, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Birukov, Anna, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Bueno-De-mesquita, H. Bas, Vermeulen, Roel C. H., Gram, Inger T., Skeie, Guri, Sandanger, Torkjel M., Quirós, J. Ramón, Crous-Bou, Marta, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Gurrea, Aurelio Barricarte, Manjer, Jonas, Johansson, Ingegerd, Perez-Cornago, Aurora, Jenab, Mazda, and Fedirko, Veronika
Abstract: Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation and have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated. Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence intervals for associations between dietary intake of AGEs with CRC-specific and all-cause mortality among 5801 participant cases diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition study between 1993 and 2013. Dietary intakes of AGEs were estimated using country-specific dietary questionnaires, linked to an AGE database, that accounted for food preparation and processing. During a median of 58 months of follow-up, 2421 cases died (1841 from CRC). Individually or combined, dietary intakes of AGEs were not associated with all-cause and CRC-specific mortality among cases. However, there was a suggestion for a positive association between AGEs and all-cause or CRC-specific mortality among CRC cases without type II diabetes (all-cause, Pinteraction = 0.05) and CRC cases with the longest follow-up between recruitment and cancer diagnosis (CRC-specific, Pinteraction = 0.003; all-cause, Pinteraction = 0.01). Our study suggests that pre-diagnostic dietary intakes of AGEs were not associated with CRC-specific or all-cause mortality among CRC patients. Further investigations using biomarkers of AGEs and stratifying by sex, diabetes status, and timing of exposure to AGEs are warranted.
Published: 2021
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36. Polyphenol intake and epithelial ovarian cancer risk in the European prospective investigation into cancer and nutrition (Epic) study

Author: Londoño, Catalina, Cayssials, Valerie, de Villasante, Izar, Crous-Bou, Marta, Scalbert, Augustin, Weiderpass, Elisabete, Agudo, Antonio, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Katzke, Verena, Schulze, Matthias, Palli, Domenico, Krogh, Vittorio, de Magistris, Maria Santucci, Tumino, Rosario, Ricceri, Fulvio, Gram, Inger T., Rylander, Charlotta, Skeie, Guri, Sánchez, Maria-Jose, Amiano, Pilar, Huerta, José María, Barricarte, Aurelio, Sartor, Hanna, Sonestedt, Emily, Esberg, Anders, Idahl, Annika, Mahamat-Saleh, Yahya, Laouali, Nasser, Kvaskoff, Marina, Turzanski-Fortner, Renée, Zamora-Ros, Raul, Londoño, Catalina, Cayssials, Valerie, de Villasante, Izar, Crous-Bou, Marta, Scalbert, Augustin, Weiderpass, Elisabete, Agudo, Antonio, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Katzke, Verena, Schulze, Matthias, Palli, Domenico, Krogh, Vittorio, de Magistris, Maria Santucci, Tumino, Rosario, Ricceri, Fulvio, Gram, Inger T., Rylander, Charlotta, Skeie, Guri, Sánchez, Maria-Jose, Amiano, Pilar, Huerta, José María, Barricarte, Aurelio, Sartor, Hanna, Sonestedt, Emily, Esberg, Anders, Idahl, Annika, Mahamat-Saleh, Yahya, Laouali, Nasser, Kvaskoff, Marina, Turzanski-Fortner, Renée, and Zamora-Ros, Raul
Abstract: Despite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a large prospective study. The study was conducted in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 309,129 adult women recruited mostly from the general population. Polyphenol intake was assessed through validated country-specific dietary questionnaires and the Phenol-Explorer database. During a mean follow-up of 14 years, 1469 first incident EOC cases (including 806 serous, 129 endometrioid, 102 mucinous, and 67 clear cell tumours) were identified. In multivariable-adjusted Cox regression models, the hazard ratio in the highest quartile of total polyphenol intake compared with the lowest quartile (HRQ4vsQ1 ) was 1.14 (95% CI 0.94–1.39; p-trend = 0.11). Similarly, the intake of most classes and subclasses of polyphenols were not related to either overall EOC risk or any EOC subtype. A borderline statistically significant positive association was observed between phenolic acid intake (HRQ4vsQ1 = 1.20, 95% CI 1.01–1.43; p-trend = 0.02) and EOC risk, especially for the serous subtype and in women with obesity, although these associations did not exceed the Bonferroni correction threshold. The current results do not support any association between polyphenol intake and EOC in our large European prospective study. Results regarding phenolic acid intake need further investigation.
Published: 2021
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37. Inflammatory potential of the diet and risk of breast cancer in the European Investigation into Cancer and Nutrition (EPIC) study

Author: Castro-Espin, Carlota, Agudo, Antonio, Bonet, Catalina, Katzke, Verena, Turzanski-Fortner, Renée, Aleksandrova, Krasimira, Schulze, Matthias B., Tjønneland, Anne, Dahm, Christina C., Quirós, José-Ramón, Sánchez, María-José, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, May, Anne M., Bodén, Stina, Gram, Inger T., Skeie, Guri, Laouali, Nasser, Shah, Sanam, Severi, Gianluca, Aune, Dagfinn, Merritt, Melissa A., Cairat, Manon, Weiderpass, Elisabete, Riboli, Elio, Dossus, Laure, Jakszyn, Paula, Castro-Espin, Carlota, Agudo, Antonio, Bonet, Catalina, Katzke, Verena, Turzanski-Fortner, Renée, Aleksandrova, Krasimira, Schulze, Matthias B., Tjønneland, Anne, Dahm, Christina C., Quirós, José-Ramón, Sánchez, María-José, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, May, Anne M., Bodén, Stina, Gram, Inger T., Skeie, Guri, Laouali, Nasser, Shah, Sanam, Severi, Gianluca, Aune, Dagfinn, Merritt, Melissa A., Cairat, Manon, Weiderpass, Elisabete, Riboli, Elio, Dossus, Laure, and Jakszyn, Paula
Abstract: The role of chronic inflammation on breast cancer (BC) risk remains unclear beyond as an underlying mechanism of obesity and physical activity. We aimed to evaluate the association between the inflammatory potential of the diet and risk of BC overall, according to menopausal status and tumour subtypes. Within the European Prospective Investigation into Cancer and Nutrition cohort, 318,686 women were followed for 14 years, among whom 13,246 incident BC cases were identified. The inflammatory potential of the diet was characterized by an inflammatory score of the diet (ISD). Multivariable Cox regression models were used to assess the potential effect of the ISD on BC risk by means of hazard ratios (HR) and 95% confidence intervals (CI). ISD was positively associated with BC risk. Each increase of one standard deviation (1-Sd) of the score increased by 4% the risk of BC (HR = 1.04; 95% CI 1.01–1.07). Women in the highest quintile of the ISD (indicating a most pro-inflammatory diet) had a 12% increase in risk compared with those in the lowest quintile (HR = 1.12; 95% CI 1.04–1.21) with a significant trend. The association was strongest among premenopausal women, with an 8% increased risk for 1-Sd increase in the score (HR = 1.08; 95% CI 1.01–1.14). The pattern of the association was quite homogeneous by BC subtypes based on hormone receptor status. There were no significant interactions between ISD and body mass index, physical activity, or alcohol consumption. Women consuming more pro-inflammatory diets as measured by ISD are at increased risk for BC, especially premenopausal women.
Published: 2021
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38. Red blood cell fatty acids and risk of colorectal cancer in the European Prospective investigation into cancer and nutrition (EPIC)

Author: Linseisen, Jakob, Grundmann, Nina, Zoller, Dorothee, Kuhn, Tilman, Jansen, Eugene H.J.M., Chajes, Veronique, Fedirko, Veronika, Weiderpass, Elisabete, Dahm, Christina C., Overvad, Kim, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Rothwell, Joseph A., Severi, Gianluca, Kaaks, Rudolf, Schulze, Matthias B., Aleksandrova, Krasimira, Sieri, Sabina, Panico, Salvatore, Tumino, Rosario, Masala, Giovanna, de Marco, Laura, Bueno-De-Mesquita, Bas, Vermeulen, Roel, Gram, Inger T., Skeie, Guri, Chirlaque, María-Dolores, Ardanaz, Eva, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Wennberg, Maria, Bodén, Stina, Perez-Cornago, Aurora, Aglago, Elom K., Gunter, Marc J., Jenab, Mazda, Heath, Alicia K., Nieters, Alexandra, Linseisen, Jakob, Grundmann, Nina, Zoller, Dorothee, Kuhn, Tilman, Jansen, Eugene H.J.M., Chajes, Veronique, Fedirko, Veronika, Weiderpass, Elisabete, Dahm, Christina C., Overvad, Kim, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Rothwell, Joseph A., Severi, Gianluca, Kaaks, Rudolf, Schulze, Matthias B., Aleksandrova, Krasimira, Sieri, Sabina, Panico, Salvatore, Tumino, Rosario, Masala, Giovanna, de Marco, Laura, Bueno-De-Mesquita, Bas, Vermeulen, Roel, Gram, Inger T., Skeie, Guri, Chirlaque, María-Dolores, Ardanaz, Eva, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Wennberg, Maria, Bodén, Stina, Perez-Cornago, Aurora, Aglago, Elom K., Gunter, Marc J., Jenab, Mazda, Heath, Alicia K., and Nieters, Alexandra
Abstract: Background: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer risk. However, data from large-scale epidemiologic studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce. Methods: We investigate the association between red blood cell (RBC) membrane FAs and risk of colorectal cancer in a case–control study nested within a large prospective cohort. After a median follow-up of 6.4 years, 1,069 incident colorectal cancer cases were identified and matched to 1,069 controls among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). The FA composition of RBC phospholipids (in mol%) was analyzed by gas chromatography, and their association with risk of colorectal cancer was estimated by multivariable adjusted conditional logistic regression models. Results: After correction for multiple testing, subjects with higher concentrations of RBC stearic acid were at higher risk for colorectal cancer (OR ¼ 1.23; 95% CI ¼ 1.07–1.42, per 1 mol%). Conversely, colorectal cancer incidence decreased with increasing proportions of RBC n-3 PUFA, particularly eicosapentaenoic acid (0.75; 0.62–0.92, per 1 mol%). The findings for the n-6 PUFA arachidonic acid were inconsistent. Conclusions: The positive association between prediagnostic RBC stearic acid and colorectal cancer reflects putative differences in FA intake and metabolism between cancer cases and matched controls, which deserve further investigation. The inverse relationship between EPA and colorectal cancer is in line with the repeatedly reported protective effect of fish consumption on colorectal cancer risk. Impact: These findings add to the evidence on colorectal cancer prevention.
Published: 2021
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39. Causal effects of lifetime smoking on breast and colorectal cancer risk: Mendelian randomization study

Author: Dimou, Niki, Yarmolinsky, James, Bouras, Emmanouil, Tsilidis, Konstantinos K., Martin, Richard M., Lewis, Sarah J., Gram, Inger T., Bakker, Marije F., Brenner, Hermann, Figueiredo, Jane C., Fortner, Renee T., Gruber, Stephen B., van Guelpen, Bethany, Hsu, Li, Kaaks, Rudolf, Kweon, Sun-Seog, Lin, Yi, Lindor, Noralane M., Newcomb, Polly A., Sanchez, Maria-Jose, Severi, Gianluca, Tindle, Hilary A., Tumino, Rosario, Weiderpass, Elisabete, Gunter, Marc J., Murphy, Neil, Dimou, Niki, Yarmolinsky, James, Bouras, Emmanouil, Tsilidis, Konstantinos K., Martin, Richard M., Lewis, Sarah J., Gram, Inger T., Bakker, Marije F., Brenner, Hermann, Figueiredo, Jane C., Fortner, Renee T., Gruber, Stephen B., van Guelpen, Bethany, Hsu, Li, Kaaks, Rudolf, Kweon, Sun-Seog, Lin, Yi, Lindor, Noralane M., Newcomb, Polly A., Sanchez, Maria-Jose, Severi, Gianluca, Tindle, Hilary A., Tumino, Rosario, Weiderpass, Elisabete, Gunter, Marc J., and Murphy, Neil
Abstract: Background: Observational evidence has shown that smoking is a risk factor for breast and colorectal cancer. We used Mendelian randomization (MR) to examine causal associations between smoking and risks of breast and colorectal cancer. Methods: Genome-Wide Association Study summary data were used to identify genetic variants associated with lifetime amount of smoking (n ¼ 126 variants) and ever having smoked regularly (n ¼ 112 variants). Using two-sample MR, we examined these variants in relation to incident breast (122,977 cases/ 105,974 controls) and colorectal cancer (52,775 cases/45,940 controls). Results: In inverse-variance weighted models, a genetic predisposition to higher lifetime amount of smoking was positively associated with breast cancer risk [OR per 1-SD increment: 1.13; 95% confidence interval (CI): 1.00–1.26; P ¼ 0.04]; although heterogeneity was observed. Similar associations were found for estrogen receptor–positive and estrogen receptor–negative tumors. Higher lifetime amount of smoking was positively associated with colorectal cancer (OR per 1-SD increment, 1.21; 95% CI, 1.04–1.40; P ¼ 0.01), colon cancer (OR, 1.31; 95% CI, 1.11–1.55; P < 0.01), and rectal cancer (OR, 1.36; 95% CI, 1.07–1.73; P ¼ 0.01). Ever having smoked regularly was not associated with risks of breast (OR, 1.01; 95% CI, 0.90–1.14; P ¼ 0.85) or colorectal cancer (OR, 0.97; 95% CI, 0.86–1.10; P ¼ 0.68). Conclusions: These findings are consistent with prior observational evidence and support a causal role of higher lifetime smoking amount in the development of breast and colorectal cancer. Impact: The results from this comprehensive MR analysis indicate that lifetime smoking is a causal risk factor for these common malignancies.
Published: 2021
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40. Risk prediction for renal cell Carcinoma: Results from the European Prospective Investigation into Cancer and nutrition (EPIC) prospective cohort study

Author: Singleton, Rosie K., Heath, Alicia K., Clasen, Joanna L., Scelo, Ghislaine, Johansson, Mattias, Le Calvez-Kelm, Florence, Weiderpass, Elisabete, Liedberg, Fredrik, Ljungberg, Börje, Harbs, Justin, Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Kaaks, Rudolf, Fortner, Renee T., Panico, Salvatore, Tagliabue, Giovanna, Masala, Giovanna, Tumino, Rosario, Ricceri, Fulvio, Gram, Inger T., Santiuste, Carmen, Bonet, Catalina, Rodriguez-Barranco, Miguel, Schulze, Mattias B., Bergmann, Manuela M., Travis, Ruth C., Tzoulaki, Ioanna, Riboli, Elio, Muller, David C., Singleton, Rosie K., Heath, Alicia K., Clasen, Joanna L., Scelo, Ghislaine, Johansson, Mattias, Le Calvez-Kelm, Florence, Weiderpass, Elisabete, Liedberg, Fredrik, Ljungberg, Börje, Harbs, Justin, Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Kaaks, Rudolf, Fortner, Renee T., Panico, Salvatore, Tagliabue, Giovanna, Masala, Giovanna, Tumino, Rosario, Ricceri, Fulvio, Gram, Inger T., Santiuste, Carmen, Bonet, Catalina, Rodriguez-Barranco, Miguel, Schulze, Mattias B., Bergmann, Manuela M., Travis, Ruth C., Tzoulaki, Ioanna, Riboli, Elio, and Muller, David C.
Abstract: Background: Early detection of renal cell carcinoma (RCC) has the potential to improve disease outcomes. No screening program for sporadic RCC is in place. Given relatively low incidence, screening would need to focus on people at high risk of clinically meaningful disease so as to limit overdiagnosis and screen-detected false positives. Methods: Among 192,172 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (including 588 incident RCC cases), we evaluated a published RCC risk prediction model (including age, sex, BMI, and smoking status) in terms of discrimination (C-statistic) and calibration (observed probability as a function of predicted probability). We used a flexible parametric survival model to develop an expanded model including age, sex, BMI, and smoking status, with the addition of self-reported history of hypertension and measured blood pressure. Results: The previously published model yielded well-calibrated probabilities and good discrimination (C-statistic [95% CI]: 0.699 [0.679–0.721]). Our model had slightly improved discrimination (0.714 [0.694–0.735], bootstrap optimism-corrected C-statistic: 0.709). Despite this good performance, predicted risk was low for the vast majority of participants, with 70% of participants having 10-year risk less than 0.0025. Conclusions: Although the models performed well for the prediction of incident RCC, they are currently insufficiently powerful to identify individuals at substantial risk of RCC in a general population. Impact: Despite the promising performance of the EPIC RCC risk prediction model, further development of the model, possibly including biomarkers of risk, is required to enable risk stratification of RCC.
Published: 2021
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41. Risk Prediction for Renal Cell Carcinoma:Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Prospective Cohort Study

Author: Singleton, Rosie K., Heath, Alicia K., Clasen, Joanna L., Scelo, Ghislaine, Johansson, Mattias, Le Calvez-Kelm, Florence, Weiderpass, Elisabete, Liedberg, Fredrik, Ljungberg, Borje, Harbs, Justin, Olsen, Anja, Tjonneland, Anne, Dahm, Christina C., Kaaks, Rudolf, Fortner, Renee T., Panico, Salvatore, Tagliabue, Giovanna, Masala, Giovanna, Tumino, Rosario, Ricceri, Fulvio, Gram, Inger T., Santiuste, Carmen, Bonet, Catalina, Rodriguez-Barranco, Miguel, Schulze, Mattias B., Bergmann, Manuela M., Travis, Ruth C., Tzoulaki, Ioanna, Riboli, Elio, Muller, David C., Singleton, Rosie K., Heath, Alicia K., Clasen, Joanna L., Scelo, Ghislaine, Johansson, Mattias, Le Calvez-Kelm, Florence, Weiderpass, Elisabete, Liedberg, Fredrik, Ljungberg, Borje, Harbs, Justin, Olsen, Anja, Tjonneland, Anne, Dahm, Christina C., Kaaks, Rudolf, Fortner, Renee T., Panico, Salvatore, Tagliabue, Giovanna, Masala, Giovanna, Tumino, Rosario, Ricceri, Fulvio, Gram, Inger T., Santiuste, Carmen, Bonet, Catalina, Rodriguez-Barranco, Miguel, Schulze, Mattias B., Bergmann, Manuela M., Travis, Ruth C., Tzoulaki, Ioanna, Riboli, Elio, and Muller, David C.
Abstract: Background: Early detection of renal cell carcinoma (RCC) has the potential to improve disease outcomes. No screening program for sporadic RCC is in place. Given relatively low incidence, screening would need to focus on people at high risk of clinically meaningful disease so as to limit overdiagnosis and screen-detected false positives.Methods: Among 192,172 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (including 588 incident RCC cases), we evaluated a published RCC risk prediction model (including age, sex, BMI, and smoking status) in terms of discrimination (C-statistic) and calibration (observed probability as a function of predicted probability). We used a flexible parametric survival model to develop an expanded model including age, sex, BMI, and smoking status, with the addition of self-reported history of hypertension and measured blood pressure.Results: The previously published model yielded well-calibrated probabilities and good discrimination (C-statistic [95% CI]: 0.699 [0.679-0.721]). Our model had slightly improved discrimination (0.714 [0.694-0.735], bootstrap optimism-corrected C-statistic: 0.709). Despite this good performance, predicted risk was low for the vast majority of participants, with 70% of participants having 10-year risk less than 0.0025.Conclusions: Although the models performed well for the prediction of incident RCC, they are currently insufficiently powerful to identify individuals at substantial risk of RCC in a general population.Impact: Despite the promising performance of the EPIC RCC risk prediction model, further development of the model, possibly including biomarkers of risk, is required to enable risk stratification of RCC.
Published: 2021

42. Inflammatory potential of the diet and risk of breast cancer in the European Investigation into Cancer and Nutrition (EPIC) study

Author: Epidemiology & Health Economics, Cancer, JC onderzoeksprogramma Kanker, Castro-Espin, Carlota, Agudo, Antonio, Bonet, Catalina, Katzke, Verena, Turzanski-Fortner, Renée, Aleksandrova, Krasimira, Schulze, Matthias B, Tjønneland, Anne, Dahm, Christina C, Quirós, José-Ramón, Sánchez, María-José, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, May, Anne M, Bodén, Stina, Gram, Inger T, Skeie, Guri, Laouali, Nasser, Shah, Sanam, Severi, Gianluca, Aune, Dagfinn, Merritt, Melissa A, Cairat, Manon, Weiderpass, Elisabete, Riboli, Elio, Dossus, Laure, Jakszyn, Paula, Epidemiology & Health Economics, Cancer, JC onderzoeksprogramma Kanker, Castro-Espin, Carlota, Agudo, Antonio, Bonet, Catalina, Katzke, Verena, Turzanski-Fortner, Renée, Aleksandrova, Krasimira, Schulze, Matthias B, Tjønneland, Anne, Dahm, Christina C, Quirós, José-Ramón, Sánchez, María-José, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, May, Anne M, Bodén, Stina, Gram, Inger T, Skeie, Guri, Laouali, Nasser, Shah, Sanam, Severi, Gianluca, Aune, Dagfinn, Merritt, Melissa A, Cairat, Manon, Weiderpass, Elisabete, Riboli, Elio, Dossus, Laure, and Jakszyn, Paula
Published: 2021

43. Causal effects of lifetime smoking on breast and colorectal cancer risk: Mendelian randomization study

Author: Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Dimou, Niki, Yarmolinsky, James, Bouras, Emmanouil, Tsilidis, Konstantinos K, Martin, Richard M, Lewis, Sarah J, Gram, Inger T, Bakker, Marije F, Brenner, Hermann, Figueiredo, Jane C, Fortner, Renée Turzanski, Gruber, Stephen B, Van Guelpen, Bethany, Hsu, Li, Kaaks, Rudolf, Kweon, Sun-Seog, Lin, Yi, Lindor, Noralane M, Newcomb, Polly A, Sanchez-Perez, Maria-Jose, Severi, Gianluca, Tindle, Hilary A, Tumino, Rosario, Weiderpass, Elisabete, Gunter, Marc J, Murphy, Neil, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Dimou, Niki, Yarmolinsky, James, Bouras, Emmanouil, Tsilidis, Konstantinos K, Martin, Richard M, Lewis, Sarah J, Gram, Inger T, Bakker, Marije F, Brenner, Hermann, Figueiredo, Jane C, Fortner, Renée Turzanski, Gruber, Stephen B, Van Guelpen, Bethany, Hsu, Li, Kaaks, Rudolf, Kweon, Sun-Seog, Lin, Yi, Lindor, Noralane M, Newcomb, Polly A, Sanchez-Perez, Maria-Jose, Severi, Gianluca, Tindle, Hilary A, Tumino, Rosario, Weiderpass, Elisabete, Gunter, Marc J, and Murphy, Neil
Published: 2021

44. Causal Effects of Lifetime Smoking on Breast and Colorectal Cancer Risk: Mendelian Randomization Study

Author: Dimou, Niki, primary, Yarmolinsky, James, additional, Bouras, Emmanouil, additional, Tsilidis, Konstantinos K., additional, Martin, Richard M., additional, Lewis, Sarah J., additional, Gram, Inger T., additional, Bakker, Marije F., additional, Brenner, Hermann, additional, Figueiredo, Jane C., additional, Fortner, Renée T., additional, Gruber, Stephen B., additional, van Guelpen, Bethany, additional, Hsu, Li, additional, Kaaks, Rudolf, additional, Kweon, Sun-Seog, additional, Lin, Yi, additional, Lindor, Noralane M., additional, Newcomb, Polly A., additional, Sánchez, Maria-Jose, additional, Severi, Gianluca, additional, Tindle, Hilary A., additional, Tumino, Rosario, additional, Weiderpass, Elisabete, additional, Gunter, Marc J., additional, and Murphy, Neil, additional
Published: 2021
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45. Risk Prediction for Renal Cell Carcinoma: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Prospective Cohort Study

Author: Singleton, Rosie K., primary, Heath, Alicia K., additional, Clasen, Joanna L., additional, Scelo, Ghislaine, additional, Johansson, Mattias, additional, Calvez-Kelm, Florence Le, additional, Weiderpass, Elisabete, additional, Liedberg, Fredrik, additional, Ljungberg, Börje, additional, Harbs, Justin, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Dahm, Christina C., additional, Kaaks, Rudolf, additional, Fortner, Renée T., additional, Panico, Salvatore, additional, Tagliabue, Giovanna, additional, Masala, Giovanna, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Gram, Inger T., additional, Santiuste, Carmen, additional, Bonet, Catalina, additional, Rodriguez-Barranco, Miguel, additional, Schulze, Mattias B., additional, Bergmann, Manuela M., additional, Travis, Ruth C., additional, Tzoulaki, Ioanna, additional, Riboli, Elio, additional, and Muller, David C., additional
Published: 2021
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46. Menstrual Factors, Reproductive History, Hormone Use, and Urothelial Carcinoma Risk : A Prospective Study in the EPIC Cohort

Author: Lujan-Barroso, Leila, Botteri, Edoardo, Caini, Saverio, Ljungberg, Boerje, Roswall, Nina, Tjonneland, Anne, Bueno-de-Mesquita, Bas, Gram, Inger T., Tumino, Rosario, Kiemeney, Lambertus A., Liedberg, Fredrik, Stocks, Tanja, Gunter, Marc J., Murphy, Neil, Cervenka, Iris, Fournier, Agnes, Kvaskoff, Marina, Häggström, Christel, Overvad, Kim, Lund, Eiliv, Waaseth, Marit, Turzanski Fortner, Renee, Kuhn, Tilman, Menendez, Virginia, Sanchez, Maria-Jose, Santiuste, Carmen, Perez-Cornago, Aurora, Zamora-Ros, Raul, Cross, Amanda J., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Krogh, Vittorio, Sciannameo, Veronica, Mattiello, Amalia, Panico, Salvatore, van Gils, Carla H., Onland-Moret, N. Charlotte, Barricarte, Aurelio, Amiano, Pilar, Khaw, Kay-Tee, Boeing, Heiner, Weiderpass, Elisabete, Duell, Eric J., Lujan-Barroso, Leila, Botteri, Edoardo, Caini, Saverio, Ljungberg, Boerje, Roswall, Nina, Tjonneland, Anne, Bueno-de-Mesquita, Bas, Gram, Inger T., Tumino, Rosario, Kiemeney, Lambertus A., Liedberg, Fredrik, Stocks, Tanja, Gunter, Marc J., Murphy, Neil, Cervenka, Iris, Fournier, Agnes, Kvaskoff, Marina, Häggström, Christel, Overvad, Kim, Lund, Eiliv, Waaseth, Marit, Turzanski Fortner, Renee, Kuhn, Tilman, Menendez, Virginia, Sanchez, Maria-Jose, Santiuste, Carmen, Perez-Cornago, Aurora, Zamora-Ros, Raul, Cross, Amanda J., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Krogh, Vittorio, Sciannameo, Veronica, Mattiello, Amalia, Panico, Salvatore, van Gils, Carla H., Onland-Moret, N. Charlotte, Barricarte, Aurelio, Amiano, Pilar, Khaw, Kay-Tee, Boeing, Heiner, Weiderpass, Elisabete, and Duell, Eric J.
Abstract: Background: Urothelial carcinoma is the predominant (95%) bladder cancer subtype in industrialized nations. Animal and epidemiologic human studies suggest that hormonal factors may influence urothelial carcinoma risk. Methods: Weused an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort. Associations between hormonal factors and incident urothelial carcinoma (overall and by tumor grade, tumor aggressiveness, and non-muscle-invasive urothelial carcinoma) risk were evaluated using Cox proportional hazards models. Results: During a mean of 15 years of follow-up, 529 women developed urothelial carcinoma. In a model including number of full-term pregnancies (FTP), menopausal status, and menopausal hormone therapy (MHT), number of FTP was inversely associated with urothelial carcinoma risk (HR= 5vs1 = 0.48; 0.25-0.90; Ptrend in parous women = 0.010) and MHT use (compared with nonuse) was positively associated with urothelial carcinoma risk (HR = 1.27; 1.03-1.57), but no dose response by years of MHT use was observed. No modification of HRs by smoking status was observed. Finally, sensitivity analyses in never smokers showed similar HR patterns for the number of FTP, while no association between MHT use and urothelial carcinoma risk was observed. Association between MHT use and urothelial carcinoma risk remained significant only in current smokers. No heterogeneity of the risk estimations in the final model was observed by tumor aggressiveness or by tumor grade. A positive association between MTH use and non-muscleinvasive urothelial carcinoma risk was observed. Conclusions: Our results support that increasing the number of FTP may reduce urothelial carcinoma risk. Impact: More detailed studies on parity are needed to understand the possible effects of perinatal hormone changes in urothelial cells.
Published: 2020
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47. Adult weight change and premenopausal breast cancer risk : A prospective pooled analysis of data from 628,463 women

Author: Schoemaker, Minouk J., Nichols, Hazel B., Wright, Lauren B., Brook, Mark N., Jones, Michael E., O'Brien, Katie M., Adami, Hans-Olov, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A., Boutron-Ruault, Marie-Christine, Chen, Yu, Connor, Avonne E., Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M., Larsson, Susanna C., Linet, Martha, Ma, Huiyan, Milne, Roger L., Ozasa, Kotaro, Palmer, Julie R., Riboli, Elio, Rohan, Thomas E., Sacerdote, Carlotta, Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M., Trichopoulou, Antonia, Ursin, Giske, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Sandler, Dale P., Swerdlow, Anthony J., Schoemaker, Minouk J., Nichols, Hazel B., Wright, Lauren B., Brook, Mark N., Jones, Michael E., O'Brien, Katie M., Adami, Hans-Olov, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A., Boutron-Ruault, Marie-Christine, Chen, Yu, Connor, Avonne E., Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M., Larsson, Susanna C., Linet, Martha, Ma, Huiyan, Milne, Roger L., Ozasa, Kotaro, Palmer, Julie R., Riboli, Elio, Rohan, Thomas E., Sacerdote, Carlotta, Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M., Trichopoulou, Antonia, Ursin, Giske, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Sandler, Dale P., and Swerdlow, Anthony J.
Abstract: Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 were diagnosed with breast cancer before menopause. Models adjusted for initial weight at ages 18-24 years and other breast cancer risk factors showed that weight gain from ages 18-24 to 35-44 or to 45-54 years was inversely associated with breast cancer overall (e.g., HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.95-0.98) and with oestrogen-receptor(ER)-positive breast cancer (HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.94-0.98). Weight gain from ages 25-34 was inversely associated with ER-positive breast cancer only and weight gain from ages 35-44 was not associated with risk. None of these weight gains were associated with ER-negative breast cancer. Weight loss was not consistently associated with overall or ER-specific risk after adjusting for initial weight. Weight increase from early-adulthood to ages 45-54 years is associated with a reduced premenopausal breast cancer risk independently of early-adulthood weight. Biological explanations are needed to account for these two separate factors.
Published: 2020
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48. Ovarian Cancer Risk Factor Associations by Primary Anatomic Site : The Ovarian Cancer Cohort Consortium

Author: Fortner, Renee T., Rice, Megan S., Knutsen, Synnove F., Orlich, Michael J., Visvanathan, Kala, Patel, Alpa, V, Gaudet, Mia M., Tjønneland, Anne, Kvaskoff, Marina, Kaaks, Rudolf, Trichopolou, Antonia, Pala, Valeria, Onland-Moret, N. Charlotte, Gram, Inger T., Amiano, Pilar, Idahl, Annika, Allen, Naomi E., Weiderpass, Elisabete, Poynter, Jenny N., Robien, Kim, Giles, Graham G., Milne, Roger L., Setiawan, Veronica W., Merritt, Melissa A., van den Brandt, Piet A., Zeleniuch-Jacquotte, Anne, Arslan, Alan A., O'Brien, Katie M., Sandler, Dale P., Wolk, Alicja, Håkansson, Niclas, Harris, Holly R., Trabert, Britton, Wentzensen, Nicolas, Tworoger, Shelley S., Schouten, Leo J., Fortner, Renee T., Rice, Megan S., Knutsen, Synnove F., Orlich, Michael J., Visvanathan, Kala, Patel, Alpa, V, Gaudet, Mia M., Tjønneland, Anne, Kvaskoff, Marina, Kaaks, Rudolf, Trichopolou, Antonia, Pala, Valeria, Onland-Moret, N. Charlotte, Gram, Inger T., Amiano, Pilar, Idahl, Annika, Allen, Naomi E., Weiderpass, Elisabete, Poynter, Jenny N., Robien, Kim, Giles, Graham G., Milne, Roger L., Setiawan, Veronica W., Merritt, Melissa A., van den Brandt, Piet A., Zeleniuch-Jacquotte, Anne, Arslan, Alan A., O'Brien, Katie M., Sandler, Dale P., Wolk, Alicja, Håkansson, Niclas, Harris, Holly R., Trabert, Britton, Wentzensen, Nicolas, Tworoger, Shelley S., and Schouten, Leo J.
Abstract: Background: Epithelial ovarian, fallopian tube, and primary peritoneal cancers have shared developmental pathways. Few studies have prospectively examined heterogeneity in risk factor associations across these three anatomic sites. Methods: We identified 3,738 ovarian, 337 peritoneal, and 176 fallopian tube incident cancer cases in 891,731 women from 15 prospective cohorts in the Ovarian Cancer Cohort Consortium. Associations between 18 putative risk factors and risk of ovarian, peritoneal, and fallopian tube cancer, overall and for serous and high-grade serous tumors, were evaluated using competing risks Cox proportional hazards regression. Heterogeneity was assessed by likelihood ratio tests. Results: Most associations did not vary by tumor site (P-het = 0.05). Associations between first pregnancy (P-het = 0.04), tubal ligation (P-het = 0.01), and early-adult (age 18-21 years) body mass index (BMI; P-het = 0.02) and risk differed between ovarian and peritoneal cancers. The association between early-adult BMI and risk further differed between peritoneal and fallopian tube cancer (P-het = 0.03). First pregnancy and tubal ligation were inversely associated with ovarian, but not peritoneal, cancer. Higher early-adult BMI was associated with higher risk of peritoneal, but not ovarian or fallopian tube, cancer. Patterns were generally similar when restricted to serous and high-grade serous cases. Conclusions: Ovarian, fallopian tube, and primary peritoneal cancers appear to have both shared and distinct etiologic pathways, although most risk factors appear to have similar associations by anatomic site. Impact: Further studies on the mechanisms underlying the differences in risk profiles may provide insights regarding the developmental origins of tumors arising in the peritoneal cavity and inform prevention efforts.
Published: 2020
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49. The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles : An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author: Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, V, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, V, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, V, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, V, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Wentzensen, Nicolas
Abstract: Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses included individual-level data from 558,709 naturally menopausal women across 20 prospective cohorts, among whom 3,246 developed invasive epithelial ovarian cancer (2,045 serous, 319 endometrioid, 184 mucinous, 121 clear cell, 577 other/unknown). Cox models were used to estimate multivariable-adjusted HRs between lifetime ovulatory cycles (LOC) and its components and ovarian cancer risk overall and by histotype. Women in the 90th percentile of LOC (>514 cycles) were almost twice as likely to be diagnosed with ovarian cancer than women in the 10th percentile (<294) [HR (95% confidence interval): 1.92 (1.60-2.30)]. Risk increased 14% per 5-year increase in LOC (60 cycles) [(1.10-1.17)]; this association remained after adjustment for LOC components: number of pregnancies and oral contraceptive use [1.08 (1.04-1.12)]. The association varied by histotype, with increased risk of serous [1.13 (1.09-1.17)], endometrioid [1.20 (1.10-1.32)], and clear cell [1.37 (1.18-1.58)], but not mucinous [0.99 (0.88-1.10), P-heterogeneity = 0.01] tumors. Heterogeneity across histotypes was reduced [P-heterogeneity = 0.15] with adjustment for LOC components [1.08 serous, 1.11 endometrioid, 1.26 clear cell, 0.94 mucinous]. Although the 10-year absolute risk of ovarian cancer is small, it roughly doubles as the number of LOC rises from approximately 300 to 500. The consistency and linearity of effects strongly support the hypothesis that each ovulation leads to small increases in the risk of most ovarian cancers, a risk that cumulates through life, suggesting this as an important area for identifying intervention strategies.
Published: 2020
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50. Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk : Results from the EPIC cohort

Author: Idahl, Annika, Le Cornet, Charlotte, Gonzalez Maldonado, Sandra, Waterboer, Tim, Bender, Noemi, Tjonneland, Anne, Hansen, Louise, Boutron-Ruault, Marie-Christine, Fournier, Agnes, Kvaskoff, Marina, Boeing, Heiner, Trichopoulou, Antonia, Valanou, Elisavet, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Onland-Moret, N. Charlotte, Gram, Inger T., Weiderpass, Elisabete, Quiros, Jose R., Duell, Eric J., Sanchez, Maria-Jose, Chirlaque, Maria-Dolores, Barricarte, Aurelio, Gil, Leire, Brandstedt, Jenny, Riesbeck, Kristian, Lundin, Eva, Khaw, Kay-Tee, Perez-Cornago, Aurora, Gunter, Marc J., Dossus, Laure, Kaaks, Rudolf, Fortner, Renee T., Idahl, Annika, Le Cornet, Charlotte, Gonzalez Maldonado, Sandra, Waterboer, Tim, Bender, Noemi, Tjonneland, Anne, Hansen, Louise, Boutron-Ruault, Marie-Christine, Fournier, Agnes, Kvaskoff, Marina, Boeing, Heiner, Trichopoulou, Antonia, Valanou, Elisavet, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Onland-Moret, N. Charlotte, Gram, Inger T., Weiderpass, Elisabete, Quiros, Jose R., Duell, Eric J., Sanchez, Maria-Jose, Chirlaque, Maria-Dolores, Barricarte, Aurelio, Gil, Leire, Brandstedt, Jenny, Riesbeck, Kristian, Lundin, Eva, Khaw, Kay-Tee, Perez-Cornago, Aurora, Gunter, Marc J., Dossus, Laure, Kaaks, Rudolf, and Fortner, Renee T.
Abstract: A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation after sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC risk in a nested case‐control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 791 cases and 1669 matched controls. Serum antibodies against C. trachomatis, Mycoplasma genitalium, herpes simplex virus type 2 (HSV‐2) and human papillomavirus (HPV) 16, 18 and 45 were assessed using multiplex fluorescent bead‐based serology. Conditional logistic regression was used to estimate relative risks (RR) and 95% confidence intervals (CI) comparing women with positive vs. negative serology. A total of 40% of the study population was seropositive to at least one STI. Positive serology to C. trachomatis Pgp3 antibodies was not associated with EOC risk overall, but with higher risk of the mucinous histotype (RR = 2.30 [95% CI = 1.22‐4.32]). Positive serology for chlamydia heat shock protein 60 (cHSP60‐1) was associated with higher risk of EOC overall (1.36 [1.13‐1.64]) and with the serous subtype (1.44 [1.12‐1.85]). None of the other evaluated STIs were associated with EOC risk overall; however, HSV‐2 was associated with higher risk of endometrioid EOC (2.35 [1.24‐4.43]). The findings of our study suggest a potential role of C. trachomatis in the carcinogenesis of serous and mucinous EOC, while HSV‐2 might promote the development of endometrioid disease.
Published: 2020
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