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Your search keyword '"Graff‐Guerrero, Ariel"' showing total 876 results
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876 results on '"Graff‐Guerrero, Ariel"'

1. Neurophysiological and other features of working memory in older adults at risk for dementia

Author

Patterson, Rachel A., Brooks, Heather, Mirjalili, Mina, Rashidi-Ranjbar, Neda, Zomorrodi, Reza, Blumberger, Daniel M., Fischer, Corinne E., Flint, Alastair J., Graff-Guerrero, Ariel, Herrmann, Nathan, Kennedy, James L., Kumar, Sanjeev, Lanctôt, Krista L., Mah, Linda, Mulsant, Benoit H., Pollock, Bruce G., Voineskos, Aristotle N., Wang, Wei, and Rajji, Tarek K.

Published
2024
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7. Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis

Author

Merritt, Kate, McCutcheon, Robert A., Aleman, André, Ashley, Sarah, Beck, Katherine, Block, Wolfgang, Bloemen, Oswald J. N., Borgan, Faith, Boules, Christiana, Bustillo, Juan R., Capizzano, Aristides A., Coughlin, Jennifer M., David, Anthony, de la Fuente-Sandoval, Camilo, Demjaha, Arsime, Dempster, Kara, Do, Kim Q., Du, Fei, Falkai, Peter, Galińska-Skok, Beata, Gallinat, Jürgen, Gasparovic, Charles, Ginestet, Cedric E., Goto, Naoki, Graff-Guerrero, Ariel, Ho, Beng-Choon, Howes, Oliver, Jauhar, Sameer, Jeon, Peter, Kato, Tadafumi, Kaufmann, Charles A., Kegeles, Lawrence S., Keshavan, Matcheri S., Kim, Sang-Young, King, Bridget, Kunugi, Hiroshi, Lauriello, J., León-Ortiz, Pablo, Liemburg, Edith, Mcilwain, Meghan E., Modinos, Gemma, Mouchlianitis, Elias, Nakamura, Jun, Nenadic, Igor, Öngür, Dost, Ota, Miho, Palaniyappan, Lena, Pantelis, Christos, Patel, Tulsi, Plitman, Eric, Posporelis, Sotirios, Purdon, Scot E., Reichenbach, Jürgen R., Renshaw, Perry F., Reyes-Madrigal, Francisco, Russell, Bruce R., Sawa, Akira, Schaefer, Martin, Shungu, Dikoma C., Smesny, Stefan, Stanley, Jeffrey A., Stone, James, Szulc, Agata, Taylor, Reggie, Thakkar, Katharine N., Théberge, Jean, Tibbo, Philip G., van Amelsvoort, Thérèse, Walecki, Jerzy, Williamson, Peter C., Wood, Stephen J., Xin, Lijing, Yamasue, Hidenori, McGuire, Philip, and Egerton, Alice

Published
2023
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10. Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment

Author

Wada, Masataka, Noda, Yoshihiro, Iwata, Yusuke, Tsugawa, Sakiko, Yoshida, Kazunari, Tani, Hideaki, Hirano, Yoji, Koike, Shinsuke, Sasabayashi, Daiki, Katayama, Haruyuki, Plitman, Eric, Ohi, Kazutaka, Ueno, Fumihiko, Caravaggio, Fernando, Koizumi, Teruki, Gerretsen, Philip, Suzuki, Takefumi, Uchida, Hiroyuki, Müller, Daniel J., Mimura, Masaru, Remington, Gary, Grace, Anthony A., Graff-Guerrero, Ariel, and Nakajima, Shinichiro

Published
2022
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18. Investigating structural subdivisions of the anterior cingulate cortex in schizophrenia, with implications for treatment resistance and glutamatergic levels

Author

Ochi, Ryo, Plitman, Eric, Patel, Raihaan, Tarumi, Ryosuke, Iwata, Yusuke, Tsugawa, Sakiko, Kim, Julia, Honda, Shiori, Noda, Yoshihiro, Uchida, Hiroyuki, Devenyi, Gabriel A., Mimura, Masaru, Graff-Guerrero, Ariel, Chakravarty, M. Mallar, and Nakajima, Shinichiro

Subjects
Anterior cingulate cortex -- Structure -- Health aspects, Schizophrenia -- Physiological aspects -- Care and treatment, Glutamate -- Physiological aspects, Health, Psychology and mental health
Abstract

Background: Abnormalities in the anterior cingulate cortex (ACC) are thought to play an important role in the pathophysiology of schizophrenia. Given regional variations in ACC structure, the present study aimed to examine ACC structural subdivisions and their relationships to treatment resistance and glutamatergic levels in schizophrenia. Methods: This study included 100 patients with schizophrenia and 52 healthy controls from 2 cohorts. We applied non-negative matrix factorization to identify accurate and stable spatial components of ACC structure. Between groups, we compared ACC structural indices in each spatial component based on treatment resistance or response and tested relationships with ACC glutamate + glutamine levels. Results: We detected reductions in cortical thickness and increases in mean diffusivity in the spatial components on the surface of the cingulate sulcus, especially in patients with treatment-resistant and clozapine-resistant schizophrenia. Notably, mean diffusivity in these components was higher in patients who did not respond to clozapine compared to those who did. Furthermore, these ACC structural alterations were related to elevated ACC glutamate + glutamine levels but not related to symptomatology or antipsychotic dose. Limitations: Sample sizes, cross-sectional findings and mixed antipsychotic status were limitations of this study. Conclusion: This study identified reproducible abnormalities in ACC structures in patients with treatment-resistant and clozapine-resistant schizophrenia. Given that these spatial components play a role in inhibitory control, the present study strengthens the notion that glutamate- related disinhibition is a common biological feature of treatment resistance in schizophrenia., Introduction Current antipsychotics fail to alleviate clinical symptoms in approximately one-third of patients with schizophrenia. (1) This subtype is termed treatment-resistant schizophrenia, which is formally defined as having an inadequate [...]

Published
2022
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21. Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis of 1H-magnetic resonance spectroscopy studies

Author

Nakahara, Tomomi, Tsugawa, Sakiko, Noda, Yoshihiro, Ueno, Fumihiko, Honda, Shiori, Kinjo, Megumi, Segawa, Hikari, Hondo, Nobuaki, Mori, Yukino, Watanabe, Honoka, Nakahara, Kazuho, Yoshida, Kazunari, Wada, Masataka, Tarumi, Ryosuke, Iwata, Yusuke, Plitman, Eric, Moriguchi, Sho, de la Fuente-Sandoval, Camilo, Uchida, Hiroyuki, Mimura, Masaru, Graff-Guerrero, Ariel, and Nakajima, Shinichiro

Published
2022
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22. Evaluation of the Glymphatic System in Schizophrenia Spectrum Disorder Using Proton Magnetic Resonance Spectroscopy Measurement of Brain Macromolecule and Diffusion Tensor Image Analysis Along the Perivascular Space Index

Author

Abdolizadeh, Ali, primary, Torres-Carmona, Edgardo, additional, Kambari, Yasaman, additional, Amaev, Aron, additional, Song, Jianmeng, additional, Ueno, Fumihiko, additional, Koizumi, Teruki, additional, Nakajima, Shinichiro, additional, Agarwal, Sri Mahavir, additional, De Luca, Vincenzo, additional, Gerretsen, Philip, additional, and Graff-Guerrero, Ariel, additional

Published
2024
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23. 389. The Anxiolytic Effect of Atypical Antipsychotics in Patients With Schizophrenia: A Systematic Review and Meta-Analysis

Author

Abdolizadeh, Ali, primary, Kupaei, Maryam Hosseini, additional, Kambari, Yasaman, additional, Amaev, Aron, additional, Korann, Vittal, additional, Torres-Carmona, Edgardo, additional, Song, Jianmeng, additional, Ueno, Fumihiko, additional, Koizumi, Teruki, additional, Nakajima, Shinichiro, additional, Agarwal, Sri Mahavir, additional, Gerretsen, Philip, additional, and Graff-Guerrero, Ariel, additional

Published
2024
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24. 413. Identifying Predictors of Clozapine-Induced Weight Gain Through a Naturalistic Retrospective Chart Review

Author

Stogios, Nicolette, primary, Maksyutynska, Kateryna, additional, Sanches, Marcos, additional, Powell, Valerie, additional, Gerretsen, Philip, additional, Graff-Guerrero, Ariel, additional, Chintoh, Araba, additional, Remington, Gary, additional, Foussias, George, additional, Hahn, Margaret, additional, and Agarwal, Sri Mahavir, additional

Published
2024
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30. White matter microstructural organizations in patients with severe treatment-resistant schizophrenia: A diffusion tensor imaging study

Author

Ochi, Ryo, Noda, Yoshihiro, Tsuchimoto, Shohei, Tarumi, Ryosuke, Honda, Shiori, Matsushita, Karin, Tsugawa, Sakiko, Plitman, Eric, Masuda, Fumi, Ogyu, Kamiyu, Wada, Masataka, Miyazaki, Takahiro, Fujii, Shinya, Chakravarty, M. Mallar, Graff-Guerrero, Ariel, Uchida, Hiroyuki, Mimura, Masaru, and Nakajima, Shinichiro

Published
2020
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34. Cortical Amyloid β Deposition and Current Depressive Symptoms in Alzheimer Disease and Mild Cognitive Impairment

Author

Chung, Jun Ku, Plitman, Eric, Nakajima, Shinichiro, Chakravarty, M Mallar, Caravaggio, Fernando, Gerretsen, Philip, Iwata, Yusuke, and Graff-Guerrero, Ariel

Subjects
Biological Psychology, Psychology, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Acquired Cognitive Impairment, Aging, Neurosciences, Brain Disorders, Depression, Alzheimer's Disease, Mental Health, Neurodegenerative, Clinical Research, Behavioral and Social Science, Dementia, Aetiology, 2.1 Biological and endogenous factors, Neurological, Mental health, Aged, Alzheimer Disease, Amyloid beta-Peptides, Aniline Compounds, Cerebral Cortex, Cognitive Dysfunction, Depressive Disorder, Major, Ethylene Glycols, Female, Humans, Male, Middle Aged, Neuroimaging, Positron-Emission Tomography, dementia, depression, beta-amyloid, Alzheimer’s Disease Neuroimaging Initiative, Clinical Sciences, Geriatrics, Clinical sciences, Biological psychology
Abstract

Depressive symptoms are frequently seen in patients with dementia and mild cognitive impairment (MCI). Evidence suggests that there may be a link between current depressive symptoms and Alzheimer disease (AD)-associated pathological changes, such as an increase in cortical amyloid-β (Aβ). However, limited in vivo studies have explored the relationship between current depressive symptoms and cortical Aβ in patients with MCI and AD. Our study, using a large sample of 455 patients with MCI and 153 patients with AD from the Alzheimer's disease Neuroimaging Initiatives, investigated whether current depressive symptoms are related to cortical Aβ deposition. Depressive symptoms were assessed using the Geriatric Depression Scale and Neuropsychiatric Inventory-depression/dysphoria. Cortical Aβ was quantified using positron emission tomography with the Aβ probe(18)F-florbetapir (AV-45).(18)F-florbetapir standardized uptake value ratio (AV-45 SUVR) from the frontal, cingulate, parietal, and temporal regions was estimated. A global AV-45 SUVR, defined as the average of frontal, cingulate, precuneus, and parietal cortex, was also used. We observed that current depressive symptoms were not related to cortical Aβ, after controlling for potential confounds, including history of major depression. We also observed that there was no difference in cortical Aβ between matched participants with high and low depressive symptoms, as well as no difference between matched participants with the presence and absence of depressive symptoms. The association between depression and cortical Aβ deposition does not exist, but the relationship is highly influenced by stressful events in the past, such as previous depressive episodes, and complex interactions of different pathways underlying both depression and dementia.

Published
2016

35. Comparing the distribution of neuropsychiatric symptoms among individuals with depression and mild cognitive impairment

Author

Keng, Alvin, primary, Kapustin, Daniel, additional, Ma, Clement, additional, Bingham, Kathleen, additional, Fischer, Corinne E., additional, Mah, Linda, additional, Gallagher, Damien, additional, Butters, Meryl A., additional, Bowie, Christopher R, additional, Voineskos, Aristotle N., additional, Graff‐Guerrero, Ariel, additional, Flint, Alastair, additional, Herrmann, Nathan, additional, Pollock, Bruce G., additional, Mulsant, Benoit H., additional, Rajji, Tarek K., additional, and Kumar, Sanjeev, additional

Published
2023
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36. Association between lipopolysaccharide, immune biomarkers and cerebral amyloid‐beta deposition in older adults with mild cognitive impairment & major depressive disorder

Author

Feng, Vivian, primary, Lanctôt, Krista L., additional, Herrmann, Nathan, additional, Kiss, Alex, additional, Fischer, Corinne E., additional, Flint, Alastair, additional, Mah, Linda, additional, Mulsant, Benoit H., additional, Pollock, Bruce G., additional, Rajji, Tarek K., additional, Tumati, Shankar, additional, Verhoeff, Nicolaas Paul L.G., additional, Graff‐Guerrero, Ariel, additional, and Gallagher, Damien, additional

Published
2023
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39. Levels of glutamatergic neurometabolites in patients with severe treatment-resistant schizophrenia: a proton magnetic resonance spectroscopy study

Author

Tarumi, Ryosuke, Tsugawa, Sakiko, Noda, Yoshihiro, Plitman, Eric, Honda, Shiori, Matsushita, Karin, Chavez, Sofia, Sawada, Kyosuke, Wada, Masataka, Matsui, Mie, Fujii, Shinya, Miyazaki, Takahiro, Chakravarty, M. Mallar, Uchida, Hiroyuki, Remington, Gary, Graff-Guerrero, Ariel, Mimura, Masaru, and Nakajima, Shinichiro

Published
2020
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47. Metformin for early comorbid glucose dysregulation and schizophrenia spectrum disorders: a pilot double-blind randomized clinical trial

Author

Agarwal, Sri Mahavir, Panda, Roshni, Costa-Dookhan, Kenya A., MacKenzie, Nicole E., Treen, Quinn Casuccio, Caravaggio, Fernando, Hashim, Eyesha, Leung, General, Kirpalani, Anish, Matheson, Kelly, Chintoh, Araba F., Kramer, Caroline K., Voineskos, Aristotle N., Graff-Guerrero, Ariel, Remington, Gary J., and Hahn, Margaret K.

Published
2021
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48. Neurocognitive correlates of metabolic dysregulation in individuals with mood disorders: a systematic review and meta-analysis.

Author

Maksyutynska, Kateryna, Stogios, Nicolette, Prasad, Femin, Gill, Jashan, Hamza, Zaineb, De, Riddhita, Smith, Emily, Horta, Angelina, Goldstein, Benjamin I., Korczak, Daphne, Graff-Guerrero, Ariel, Hahn, Margaret K., and Agarwal, Sri Mahavir

Subjects
METABOLIC disorders, SELF-evaluation, BODY mass index, EXECUTIVE function, COGNITIVE processing speed, AFFECTIVE disorders, META-analysis, QUANTITATIVE research, SYSTEMATIC reviews, INSULIN resistance, TYPE 2 diabetes, COGNITION disorders, MEMORY, OBESITY, MENTAL depression, COGNITION
Abstract

Individuals with mood disorders are predisposed to metabolic dysfunction, while those with metabolic dysregulation such as diabetes and obesity experience more severe depressive symptoms. Both metabolic dysfunction and mood disorders are independently associated with cognitive deficits. Therefore, given their close association, this study aimed to explore the association between metabolic dysfunction in individuals with mood disorders in relation to cognitive outcomes. A comprehensive search comprised of these three domains was carried out; a random-effects meta-analysis pooling mean cognitive outcomes was conducted (PROSPERO ID: CRD42022295765). Sixty-three studies were included in this review; 26 were synthesized in a quantitative meta-analysis. Comorbid metabolic dysregulation was associated with significantly lower global cognition among individuals with mood disorders. These trends were significant within each mood disorder subgroup, including major depressive disorder, bipolar disorder, and self-report depression/depressive symptoms. Type 2 diabetes was associated with the lowest cognitive performance in individuals with mood disorders, followed by peripheral insulin resistance, body mass index ⩾25 kg/m2, and metabolic syndrome. Significant reduction in scores was also observed among individual cognitive domains (in descending order) of working memory, attention, executive function, processing speed, verbal memory, and visual memory. These findings demonstrate the detrimental effects of comorbid metabolic dysfunction in individuals with mood disorders. Further research is required to understand the underlying mechanisms connecting mood disorders, metabolism, and cognition. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia.

Author

Tsugawa, Sakiko, Honda, Shiori, Noda, Yoshihiro, Wannan, Cassandra, Zalesky, Andrew, Tarumi, Ryosuke, Iwata, Yusuke, Ogyu, Kamiyu, Plitman, Eric, Ueno, Fumihiko, Mimura, Masaru, Uchida, Hiroyuki, Chakravarty, Mallar, Graff-Guerrero, Ariel, and Nakajima, Shinichiro

Subjects
DRUG therapy for schizophrenia, RESEARCH funding, ANTIPSYCHOTIC agents, MAGNETIC resonance imaging, CHI-squared test, RESEARCH, ONE-way analysis of variance, CEREBRAL cortical thinning, DISEASE progression
Abstract

Background and Hypothesis Schizophrenia is associated with widespread cortical thinning and abnormality in the structural covariance network, which may reflect connectome alterations due to treatment effect or disease progression. Notably, patients with treatment-resistant schizophrenia (TRS) have stronger and more widespread cortical thinning, but it remains unclear whether structural covariance is associated with treatment response in schizophrenia. Study Design We organized a multicenter magnetic resonance imaging study to assess structural covariance in a large population of TRS and non-TRS, who had been resistant and responsive to non-clozapine antipsychotics, respectively. Whole-brain structural covariance for cortical thickness was assessed in 102 patients with TRS, 77 patients with non-TRS, and 79 healthy controls (HC). Network-based statistics were used to examine the difference in structural covariance networks among the 3 groups. Moreover, the relationship between altered individual differentiated structural covariance and clinico-demographics was also explored. Study Results Patients with non-TRS exhibited greater structural covariance compared with HC, mainly in the fronto-temporal and fronto-occipital regions, while there were no significant differences in structural covariance between TRS and non-TRS or HC. Higher individual differentiated structural covariance was associated with lower general scores of the Positive and Negative Syndrome Scale in the non-TRS group, but not in the TRS group. Conclusions These findings suggest that reconfiguration of brain networks via coordinated cortical thinning is related to treatment response in schizophrenia. Further longitudinal studies are warranted to confirm if greater structural covariance could serve as a marker for treatment response in this disease. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Disease Progression Patterns of Brain Morphology in Schizophrenia: More Progressed Stages in Treatment Resistance

Author

Sone, Daichi, primary, Young, Alexandra, additional, Shinagawa, Shunichiro, additional, Tsugawa, Sakiko, additional, Iwata, Yusuke, additional, Tarumi, Ryosuke, additional, Ogyu, Kamiyu, additional, Honda, Shiori, additional, Ochi, Ryo, additional, Matsushita, Karin, additional, Ueno, Fumihiko, additional, Hondo, Nobuaki, additional, Koreki, Akihiro, additional, Torres-Carmona, Edgardo, additional, Mar, Wanna, additional, Chan, Nathan, additional, Koizumi, Teruki, additional, Kato, Hideo, additional, Kusudo, Keisuke, additional, de Luca, Vincenzo, additional, Gerretsen, Philip, additional, Remington, Gary, additional, Onaya, Mitsumoto, additional, Noda, Yoshihiro, additional, Uchida, Hiroyuki, additional, Mimura, Masaru, additional, Shigeta, Masahiro, additional, Graff-Guerrero, Ariel, additional, and Nakajima, Shinichiro, additional

Published
2023
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