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Your search keyword '"Graf, Mirja E"' showing total 10 results
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10 results on '"Graf, Mirja E"'

2. Changes in aortic diameter induced by weight loss: The HELENA trial- whole-body MR imaging in a dietary intervention trial

Author

Stoll, Sibylle, primary, Sowah, Solomon A., additional, Fink, Matthias A., additional, Nonnenmacher, Tobias, additional, Graf, Mirja E., additional, Johnson, Theron, additional, Schlett, Christopher L., additional, von Stackelberg, Oyunbileg, additional, Kirsten, Romy, additional, Bamberg, Fabian, additional, Keller, Jeffrey, additional, Ulrich, Cornelia M., additional, Kaaks, Rudolf, additional, Kauczor, Hans-Ulrich, additional, Rengier, Fabian, additional, Kühn, Tilman, additional, and Nattenmüller, Johanna, additional

Published
2022
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4. Effects of intermittent and continuous calorie restriction on body weight and metabolism over 50 wk: a randomized controlled trial

Author

Schübel, Ruth, primary, Nattenmüller, Johanna, additional, Sookthai, Disorn, additional, Nonnenmacher, Tobias, additional, Graf, Mirja E, additional, Riedl, Lena, additional, Schlett, Christopher L, additional, von Stackelberg, Oyunbileg, additional, Johnson, Theron, additional, Nabers, Diana, additional, Kirsten, Romy, additional, Kratz, Mario, additional, Kauczor, Hans-Ulrich, additional, Ulrich, Cornelia M, additional, Kaaks, Rudolf, additional, and Kühn, Tilman, additional

Published
2018
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5. Pre-diagnostic plasma concentrations of Fibrinogen, sGPIIb/IIIa, sP-selectin, sThrombomodulin, Thrombopoietin in relation to cancer risk: Findings from a large prospective study

Author

Graf, Mirja E., primary, Sookthai, Disorn, additional, Johnson, Theron, additional, Schübel, Ruth, additional, Maldonado, Sandra González, additional, Pletsch-Borba, Laura, additional, Katzke, Verena, additional, Bugert, Peter, additional, Hoffmeister, Michael, additional, Kaaks, Rudolf, additional, and Kühn, Tilman, additional

Published
2018
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9. The effects of intermittent calorie restriction on metabolic health: Rationale and study design of the HELENA Trial

Author

Schübel, Ruth, primary, Graf, Mirja E., additional, Nattenmüller, Johanna, additional, Nabers, Diana, additional, Sookthai, Disorn, additional, Gruner, Laura F., additional, Johnson, Theron, additional, Schlett, Christopher L., additional, von Stackelberg, Oyunbileg, additional, Kirsten, Romy, additional, Habermann, Nina, additional, Kratz, Mario, additional, Kauczor, Hans-Ulrich, additional, Ulrich, Cornelia M., additional, Kaaks, Rudolf, additional, and Kühn, Tilman, additional

Published
2016
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10. Red meat consumption and risk of cardiovascular diseases--is increased iron load a possible link?

Author

Pacheco, Daniel A Quintana, Sookthai, Disorn, Wittenbecher, Clemens, Graf, Mirja E, Schübel, Ruth, Johnson, Theron, Katzke, Verena, Jakszyn, Paula, Kaaks, Rudolf, and Kühn, Tilman

Subjects
MEAT, PHYSIOLOGY, CARDIOVASCULAR diseases risk factors, IRON, INGESTION, MYOCARDIAL infarction risk factors, CONFIDENCE intervals, FERRITIN, LONGITUDINAL method, MULTIVARIATE analysis, REGRESSION analysis, STATISTICAL significance, PROPORTIONAL hazards models, ODDS ratio
Abstract

Background: High iron load and red meat consumption could increase the risk of cardiovascular diseases (CVDs). As red meat is the main source of heme iron, which is in turn a major determinant of increased iron load, adverse cardiometabolic effects of meat consumption could be mediated by increased iron load. Objective: The object of the studywas to assess whether associations between red meat consumption and CVD risk are mediated by iron load in a population-based human study. Design: We evaluated relations between red meat consumption, iron load (plasma ferritin), and risk of CVD in the prospective EPIC-Heidelberg Study using a case-cohort sample including a random subcohort (n = 2738) and incident cases of myocardial infarction (MI, n = 555), stroke (n = 513), and CVD mortality (n = 381). Following a 4-step mediation analysis, associations between red meat consumption and iron load, red meat consumption and CVD risk, and iron load and CVD risk were assessed by multivariable regression models before finally testing to which degree associations between red meat consumption and CVD risk were attenuated by adjustment for iron status. Results: Red meat consumption was significantly positively associated with ferritin concentrations and MI risk [HR per 50 g daily intake: 1.18 (95% CI: 1.05, 1.33)], but no significant associations with stroke risk and CVD mortality were observed. While direct associations between ferritin concentrations and MI risk as well as CVD mortality were significant in age- and sex-adjusted Cox regression models, these associations were substantially attenuated and no longer significant after multivariable adjustment for classical CVD risk factors. Strikingly, ferritin concentrations were positively associated with a majority of classical CVD risk factors (age, male sex, alcohol intake, obesity, inflammation, and lower education). Conclusion: Increased ferritin concentrations may be a marker of an overall unfavorable risk factor profile rather than a mediator of greater CVD risk due to meat consumption. [ABSTRACT FROM AUTHOR]

Published
2018
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