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Your search keyword '"Gorassini, Monica A."' showing total 27 results
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27 results on '"Gorassini, Monica A."'

2. Intrinsic motoneuron properties in typical human development

Author

Mohammadalinejad, Ghazaleh, primary, Afsharipour, Babak, additional, Yacyshyn, Alex, additional, Duchcherer, Jennifer, additional, Bashuk, Jack, additional, Bennett, Erin, additional, Pearcey, Gregory E. P., additional, Negro, Francesco, additional, Quinlan, Katharina A., additional, Bennett, David J., additional, and Gorassini, Monica A., additional

Published
2024
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6. Post‐activation depression from primary afferent depolarization (PAD) produces extensor H‐reflex suppression following flexor afferent conditioning

Author

Metz, Krista, primary, Matos, Isabel Concha, additional, Hari, Krishnapriya, additional, Bseis, Omayma, additional, Afsharipour, Babak, additional, Lin, Shihao, additional, Singla, Rahul, additional, Fenrich, Keith K., additional, Li, Yaqing, additional, Bennett, David J, additional, and Gorassini, Monica A., additional

Published
2023
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8. Locomotor-related propriospinal V3 neurons produce primary afferent depolarization and modulate sensory transmission to motoneurons.

Author

Shihao Lin, Hari, Krishnapriya, Black, Sophie, Khatmi, Aysan, Fouad, Karim, Gorassini, Monica A., Yaqing Li, Lucas-Osma, Ana M., Fenrich, Keith K., and Bennett, David J.

Subjects
MOTOR neurons, GABAERGIC neurons, NEURONS, AFFERENT pathways, GLUTAMATE receptors, SPINAL cord, SENSORIMOTOR cortex
Abstract

When a muscle is stretched, sensory feedback not only causes reflexes but also leads to a depolarization of sensory afferents throughout the spinal cord (primary afferent depolarization, PAD), readying the whole limb for further disturbances. This sensoryevoked PAD is thought to be mediated by a trisynaptic circuit, where sensory input activates first-order excitatory neurons that activate GABAergic neurons that in turn activate GABAA receptors on afferents to cause PAD, though the identity of these firstorder neurons is unclear. Here, we show that these first-order neurons include propriospinal V3 neurons, as they receive extensive sensory input and in turn innervate GABAergic neurons that cause PAD, because optogenetic activation or inhibition of V3 neurons in mice mimics or inhibits sensory-evoked PAD, respectively. Furthermore, persistent inward sodium currents intrinsic to V3 neurons prolong their activity, explaining the prolonged duration of PAD. Also, local optogenetic activation of V3 neurons at one segment causes PAD in other segments, due to the long propriospinal tracts of these neurons, helping to explain the radiating nature of PAD. This in turn facilitates monosynaptic reflex transmission to motoneurons across the spinal cord. In addition, V3 neurons directly innervate proprioceptive afferents (including Ia), causing a glutamate receptor-mediated PAD (glutamate PAD). Finally, increasing the spinal cord excitability with either GABAA receptor blockers or chronic spinal cord injury causes an increase in the glutamate PAD. Overall, we show the V3 neuron has a prominent role in modulating sensory transmission, in addition to its previously described role in locomotion. NEW & NOTEWORTHY Locomotor-related propriospinal neurons depolarize sensory axons throughout the spinal cord by either direct glutamatergic axoaxonic contacts or indirect innervation of GABAergic neurons that themselves form axoaxonic contacts on sensory axons. This depolarization (PAD) increases sensory transmission to motoneurons throughout the spinal cord, readying the sensorimotor system for external disturbances. The glutamate-mediated PAD is particularly adaptable, increasing with either an acute block of GABA receptors or chronic spinal cord injury, suggesting a role in motor recovery. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Early intensive leg training to enhance walking in children with perinatal stroke: Protocol for a randomized controlled trial

Author

Hurd, Caitlin, Livingstone, Donna, Brunton, Kelly, Teves, Michelle, Zewdie, Ephrem, Smith, Allison, Ciechanski, Patrick, Gorassini, Monica A., Kirton, Adam, Watt, Man-Joe, Andersen, John, Yager, Jerome, and Yang, jaynie F.

Subjects
Stroke (Disease) -- Prevention, Therapeutics, Physiological -- Usage -- Physiological aspects -- Methods, Physical therapy -- Usage -- Physiological aspects -- Methods, Children -- Physiological aspects -- Usage -- Methods, Physical therapy for children -- Usage -- Physiological aspects -- Methods, Walking -- Methods -- Physiological aspects -- Usage, Health
Abstract

Background. Development of motor pathways is modulated by activity in these pathways, when they are maturing (ie, critical period). Perinatal stroke injures motor pathways, including the corticospinal tracts, reducing their [...]

Published
2017
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12. Supplemental Material - Early, Intensive, Lower Extremity Rehabilitation Shows Preliminary Efficacy After Perinatal Stroke: Results of a Pilot Randomized Controlled Trial

Author

Hurd, Caitlin, Livingstone, Donna, Brunton, Kelly, Smith, Allison, Gorassini, Monica, Watt, Man-Joe, Andersen, John, Kirton, Adam, and Yang, Jaynie F.

Subjects
FOS: Clinical medicine, 110308 Geriatrics and Gerontology, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental Material for Early, Intensive, Lower Extremity Rehabilitation Shows Preliminary Efficacy After Perinatal Stroke: Results of a Pilot Randomized Controlled Trial by Caitlin Hurd, Donna Livingstone, Kelly Brunton, Allison Smith, Monica Gorassini, Man-Joe Watt, John Andersen, Adam Kirton, and Jaynie F. Yang in Neurorehabilitation and Neural Repair

Published
2022
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15. GABA facilitates spike propagation through branch points of sensory axons in the spinal cord

Author

Hari, Krishnapriya, primary, Lucas-Osma, Ana M., additional, Metz, Krista, additional, Lin, Shihao, additional, Pardell, Noah, additional, Roszko, David A., additional, Black, Sophie, additional, Minarik, Anna, additional, Singla, Rahul, additional, Stephens, Marilee J., additional, Pearce, Robert A., additional, Fouad, Karim, additional, Jones, Kelvin E., additional, Gorassini, Monica A., additional, Fenrich, Keith K., additional, Li, Yaqing, additional, and Bennett, David J., additional

Published
2021
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16. Delta F Supplemental tables March 31

Author

Afsharipour, Babak, Manzur, Nagib, Duchcherer, Jennifer, Fenrich, Keith, Negro, Francesco, Quinlan, Kathy A., Bennett, David Jonathan, and Gorassini, Monica A.

Subjects
Quantitative Biology::Neurons and Cognition
Abstract

Estimation of self-sustained activity from persistent inward currents using firing rate profiles of multiple motor units in humans

Published
2020
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21. Additional file 1: of Retraining walking over ground in a powered exoskeleton after spinal cord injury: a prospective cohort study to examine functional gains and neuroplasticity

Author

Khan, Atif, Livingstone, Donna, Hurd, Caitlin, Duchcherer, Jennifer, Misiaszek, John, Gorassini, Monica, Manns, Patricia, and Jaynie Yang

Abstract

Contains results from sensory testing, transcranial magnetic stimulation, changes in walking skill and distance after long breaks in training. (PDF 202 kb)

Published
2019
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22. Supplemental_Materials – Supplemental material for Full Activation Profiles and Integrity of Corticospinal Pathways in Adults With Bilateral Spastic Cerebral Palsy

Author

Condliffe, Elizabeth G., Jeffery, Dean T., Emery, Derek J., Treit, Sarah, Beaulieu, Christian, and Gorassini, Monica A.

Subjects
FOS: Clinical medicine, 110308 Geriatrics and Gerontology, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, Supplemental_Materials for Full Activation Profiles and Integrity of Corticospinal Pathways in Adults With Bilateral Spastic Cerebral Palsy by Elizabeth G. Condliffe, Dean T. Jeffery, Derek J. Emery, Sarah Treit, Christian Beaulieu and Monica A. Gorassini in Neurorehabilitation and Neural Repair

Published
2018
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