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Your search keyword '"Gopal, Kandasamy"' showing total 12 results
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12 results on '"Gopal, Kandasamy"'

1. Contributors

Author

Abd-Elsalam, Kamel A., primary, Aguilar-Marcelino, Liliana, additional, Ahmad, Aftab, additional, Ajith, Siddharth, additional, Akhayere, Evidence, additional, Angurana, Ruby, additional, Ardra Lekshmi, A., additional, Arora, Smriti, additional, Awad, Gamal, additional, Barbosa, Matheus Teixeira, additional, Basri, Rabiya, additional, Benavides-Mendoza, Adalberto, additional, Chandrika, Kella Poorna, additional, Chhipa, Hemraj, additional, Choudhary, Anam, additional, Chuc, Nguyen Huu, additional, Cyriac, Jaiby, additional, Del Gallo, Maddalena, additional, de Silva, Madhavi, additional, Dhanjal, Daljeet Singh, additional, Dissanayake, Wathsala, additional, Djebaili, Rihab, additional, Elgharbawy, Amal A.M., additional, Elkhatib, Elsayed A., additional, Esquivel, Karen, additional, Farda, Beatrice, additional, Feregrino-Pérez, Ana A., additional, Fuentes-Lara, Laura Olivia, additional, Ghadam, Parinaz, additional, Gohari, Gholamreza, additional, Gopal, Kandasamy, additional, Gulfishan, Mohd, additional, Gupta, Urvashi, additional, Hajji-Hedfi, Lobna, additional, Hamadeen, Hala M., additional, Hernández-Rangel, R., additional, Hussien, EmanTawfik, additional, Imran, Muhammad, additional, Islam, Tofazzal, additional, Jamali, Majid, additional, Javeria, Fatima, additional, Juárez-Maldonado, Antonio, additional, Karunaratne, Veranja, additional, Kasfy, Shamfin Hossain, additional, Katoch, Vaidehi, additional, Kaur, Harry, additional, Kavaz, Doga, additional, Khan, Sultan Habibullah, additional, Khan, Zulqurnain, additional, Kottegoda, Nilwala, additional, Kumar, Anil, additional, Lekshmi, S., additional, Lich, Nguyen Quang, additional, Maity, Dipak, additional, Meena, Sankari, additional, Mohamed, Elham F., additional, Mudila, Harish, additional, Munaweera, Imalka, additional, Musheer, Nasreen, additional, Nadiha Azmi, Nor Azrini, additional, Ojeda-Barrios, Dámaris Leopoldina, additional, Pagnani, Giancarlo, additional, Pandey, Brij Bihari, additional, Pasala, Ratnakumar, additional, Pascoli, Mônica, additional, Pellegrini, Marika, additional, Pilissão, Luiz Eduardo Ben, additional, Pisante, Michele, additional, Prasher, Parteek, additional, Qureshi, Abdul Aziz, additional, R., Divya Mohan, additional, Ramamurthy, Praveen C., additional, Rehman, Shoaib Ur, additional, Riaz, Hasan, additional, Romanovski, Valentin, additional, Rosales-Pérez, A., additional, S., Hema, additional, Saboora, Azra, additional, Saha, Sumit, additional, Sambhudevan, Sreedha, additional, Sangeetha, B.M., additional, Singh, Simranjeet, additional, Singh, Joginder, additional, Smitha Chandran, S., additional, Sohrawardy, Hossain, additional, Subramanian, K.S., additional, Talniya, Naveen Chandra, additional, Thanh Kieu, Vo Thi, additional, Tortella, Gonzalo, additional, Ávila, Daiana Silva, additional, Verma, Shulbhi, additional, Viçozzi, Gabriel Pedroso, additional, Vuong, Le Dai, additional, Yadav, Praduman, additional, Yaseen, Saba, additional, and Yuvaraj, M., additional

Published
2024
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5. MCM-41 Nanoparticles for Brain Delivery: Better Choline-Esterase and Amyloid Formation Inhibition with Improved Kinetics

Author

Ajit K. Patra, Ashok Kumar Sharma, Sarita Rani, Anuj K. Sharma, Umesh Gupta, Gaurav Mishra, Awesh K. Yadav, Monika Rana, Pawan K. Pandey, and Gopal Kandasamy

Subjects
Kinetics, Biomedical Engineering, 02 engineering and technology, Mesoporous silica, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, In vitro, 0104 chemical sciences, Bioavailability, Biomaterials, chemistry.chemical_compound, chemistry, Zeta potential, Biophysics, Choline, Lysozyme, 0210 nano-technology, Ex vivo
Abstract

The present study was aimed at delivering a low bioavailability drug, rivastigmine hydrogen tartrate (RTG), to the brain through its encapsulation in mesoporous silica nanoparticles (MSNs) and targeted to amyloid inhibition in the brain. MSNs were characterized for size, zeta potential, and drug entrapment using SEM, TEM, HR-TEM, FT-IR, and PXRD. Drug-loaded MSNs were assessed for in vitro release kinetics and ex vivo followed by animal studies. The average size of the prepared blank (MCM-41B) and drug-loaded MSNs (MCM-41L) was 114 ± 2.0 and 145 ± 0.4 nm with the zeta potential of approximately -43.5 ± 1.1 and -37.6 ± 1.4 mV, respectively. MCM-41L exhibited an average entrapment efficiency of 88%. In vitro release studies exhibited early surge followed by a sluggish persistent or constant release (biphasic pattern). Hemolytic studies proved that the developed MCM-41L NPs are less hemolytic compared to RTG. A reduced ThT fluorescence was observed with MCM-41L compared to MCM-41B and RTG in the amyloid inhibition studies. A significant (

Published
2021

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