34 results on '"González-Estecha, Montserrat"'
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2. Are lead, cadmium and mercury risk factors for resistant hypertension?
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Corbatón Anchuelo, Arturo, Martell Claros, Nieves, Abad Cardiel, María, García Donaire, José Antonio, Fuentes Ferrer, Manuel, Bravo Gómez, Adrián, Llorente Martín, Elena, Zamora Trillo, Angielys, Bonmatí Torres, Gonzalo, and González-Estecha, Montserrat
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- 2024
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3. Iron, vitamins and minerals status in pediatric patients with celiac diseaseand non celiac gluten sensitivity prior to diagnosis and three months later
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Bodas, Andrés, Pérez, Óscar, Martín, Paula, Junguito, Alejandro, Sánchez, Rafael, Blanco, María Victoria, and González-Estecha, Montserrat
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- 2023
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4. The cardiomyopathy of cystic fibrosis: a modern form of Keshan disease
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Segovia-Cubero, Javier, primary, Ruiz-Bautista, Lorena, additional, Maiz-Carro, Luis, additional, Girón-Moreno, Rosa M., additional, Prados-Sánchez, M. Concepción, additional, Martínez-Martínez, M. Teresa, additional, González-Estecha, Montserrat, additional, Mingo-Santos, Susana, additional, Gómez-Bueno, Manuel, additional, Salas-Antón, Clara, additional, Cavero-Gibanel, Miguel A., additional, Pastrana-Ledesma, Miguel, additional, García-Pavía, Pablo, additional, Laporta-Hernández, Rosalía, additional, Sánchez-Ortiz, David, additional, and Alonso-Pulpón, Luis, additional
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- 2024
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5. External quality assessment schemes for inorganic elements in the clinical laboratory: Lessons from the OELM scheme
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Arnaud, Josiane, Patriarca, Marina, Fofou-Caillierez, Béatrice Ma’atem, González-Estecha, Montserrat, Gómez, MªCarmen González, De Graaf, Irene, Patriarca, Valeria, Ropert-Bouchet, Martine, Schröer-Janssen, Liesbeth, Siebelder, Carla, Te Winkel, Marieke, Ventura Alemany, Montserrat, and Weykamp, Cas
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- 2020
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6. Blood lead in children and associations with trace elements and sociodemographic factors
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Martínez-Hernanz, Ángeles, González-Estecha, Montserrat, Blanco, María, Fuentes, Manuel, Ordóñez-Iriarte, José María, Palazón-Bru, Irene, Calvo-Manuel, Elpidio, and Bodas-Pinedo, Andrés
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- 2020
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7. Impostor Syndrome as a Risk Factor in the Development of Psychiatric Symptoms in Female Doctors
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Hernanz, Ángeles Martínez, primary, Herrera de la Muela, María, additional, and González-Estecha, Montserrat, additional
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- 2020
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8. Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19
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Bermejo-Martin, Jesús F., González-Rivera, Milagros, Almansa, Raquel, Micheloud, Dariela, Tedim, Ana P., Domínguez-Gil, Marta, Resino, Salvador, Martín-Fernández, Marta, Ryan Murua, Pablo, Pérez-García, Felipe, Tamayo, Luis, Lopez-Izquierdo, Raúl, Bustamante, Elena, Aldecoa, César, Gómez, José Manuel, Rico-Feijoo, Jesús, Orduña, Antonio, Méndez, Raúl, Fernández Natal, Isabel, Megías, Gregoria, González-Estecha, Montserrat, Carriedo, Demetrio, Doncel, Cristina, Jorge, Noelia, Ortega, Alicia, de la Fuente, Amanda, del Campo, Félix, Fernández-Ratero, José Antonio, Trapiello, Wysali, González-Jiménez, Paula, Ruiz, Guadalupe, Kelvin, Alyson A., Ostadgavahi, Ali Toloue, Oneizat, Ruth, Ruiz, Luz María, Miguéns, Iria, Gargallo, Esther, Muñoz, Ioana, Pelegrin, Sara, Martín, Silvia, García Olivares, Pablo, Cedeño, Jamil Antonio, Ruiz Albi, Tomás, Puertas, Carolina, Berezo, Jose Ángel, Renedo, Gloria, Herrán, Rubén, Bustamante-Munguira, Juan, Enríquez, Pedro, Cicuendez, Ramón, Blanco, Jesús, Abadia, Jesica, Gómez Barquero, Julia, Mamolar, Nuria, Blanca-López, Natalia, Valdivia, Luis Jorge, Fernández Caso, Belén, Mantecón, María Ángeles, Motos, Anna, Fernandez-Barat, Laia, Ferrer, Ricard, Barbé, Ferrán, Torres, Antoni, Menéndez, Rosario, Eiros, José María, and Kelvin, David J.
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- 2020
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9. Relationship between serum selenium, sociodemographic variables, other trace elements and lipid profile in an adult Spanish population
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González-Estecha, Montserrat, Palazón-Bru, Irene, Bodas-Pinedo, Andrés, Trasobares, Elena, Palazón-Bru, Antonio, Fuentes, Manuel, Cuadrado-Cenzual, M. Ángeles, and Calvo-Manuel, Elpidio
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- 2017
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10. Probabilistic risk analysis of mercury intake via food consumption in Spain
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Moreno-Ortega, Alicia, Moreno-Rojas, Rafael, Martínez-Álvarez, Jesús Román, González Estecha, Montserrat, Castro González, Numa Pompilio, and Amaro López, Manuel Ángel
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- 2017
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11. Consensus document on the prevention of methylmercury exposure in Spain: Study group for the prevention of Me-Hg exposure in Spain (GEPREM-Hg)
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González-Estecha, Montserrat, Bodas-Pinedo, Andrés, Guillén-Pérez, José Jesús, Rubio-Herrera, Miguel Ángel, Martínez-Álvarez, Jesús Román, Herráiz-Martínez, Miguel Ángel, Martell-Claros, Nieves, Ordóñez-Iriarte, José Mª, Sáinz-Martín, María, Farré-Rovira, Rosaura, Martínez-Astorquiza, Txantón, García-Donaire, José Antonio, Calvo-Manuel, Elpidio, Bretón-Lesmes, Irene, Prieto-Menchero, Santiago, Llorente-Ballesteros, Mª Teresa, Martínez-García, Mª José, Moreno-Rojas, Rafael, Salas-Salvadó, Jordi, Bermejo-Barrera, Pilar, Cuadrado-Cenzual, Mª Ángeles, Gallardo-Pino, Carmen, Fuentes, María Blanco, Torres-Moreno, Miriam, Trasobares-Iglesias, Elena M., Martín, Bernardino Barceló, Arroyo-Fernández, Manuel, and Calle-Pascual, Alfonso
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- 2015
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12. The different faces of inorganic elements in SARS-CoV-2 infection
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Arnaud, Josiane, primary, González-Estecha, Montserrat, additional, and Skalny, Anatoly, additional
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- 2022
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13. Plomo en sangre, ¿cómo interpretar los nuevos valores de referencia?
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González Estecha, Montserrat
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- 2022
14. News and literature review
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García-Villanova, Rafael J., Díaz Jiménez, Julio, Mujeriego Sahuquillo, Rafael, and González Estecha, Montserrat
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Medicine - Abstract
Not available. No disponible. Não disponível.
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- 2021
15. Additional file 3 of Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19
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Bermejo-Martin, Jesús F., González-Rivera, Milagros, Almansa, Raquel, Dariela Micheloud, Tedim, Ana P., Domínguez-Gil, Marta, Resino, Salvador, Martín-Fernández, Marta, Murua, Pablo Ryan, Pérez-García, Felipe, Tamayo, Luis, Lopez-Izquierdo, Raúl, Bustamante, Elena, Aldecoa, César, Gómez, José Manuel, Rico-Feijoo, Jesús, Orduña, Antonio, Méndez, Raúl, Natal, Isabel Fernández, Megías, Gregoria, González-Estecha, Montserrat, Carriedo, Demetrio, Doncel, Cristina, Jorge, Noelia, Ortega, Alicia, Fuente, Amanda De La, Campo, Félix Del, Fernández-Ratero, José Antonio, Wysali Trapiello, González-Jiménez, Paula, Ruiz, Guadalupe, Kelvin, Alyson A., Ostadgavahi, Ali Toloue, Oneizat, Ruth, Ruiz, Luz María, Miguéns, Iria, Gargallo, Esther, Muñoz, Ioana, Pelegrin, Sara, Martín, Silvia, Olivares, Pablo García, Cedeño, Jamil Antonio, Albi, Tomás Ruiz, Puertas, Carolina, Berezo, Jose Ángel, Renedo, Gloria, Herrán, Rubén, Bustamante-Munguira, Juan, Enríquez, Pedro, Cicuendez, Ramón, Blanco, Jesús, Jesica Abadia, Barquero, Julia Gómez, Mamolar, Nuria, Blanca-López, Natalia, Valdivia, Luis Jorge, Caso, Belén Fernández, Mantecón, María Ángeles, Motos, Anna, Fernandez-Barat, Laia, Ferrer, Ricard, Ferrán Barbé, Torres, Antoni, Menéndez, Rosario, Eiros, José María, and Kelvin, David J.
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Additional file 3. Multivariate logistic regression analysis comparing outpatients against wards patients (backward stepwise selection method/Likelihood Ratio). The association between viral RNAemia with hospitalization at the wards was evaluated adjusting by major confounding factors, but it was not selected in the final model.
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- 2020
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16. SARS-CoV-2 RNA viremia is associated with a sepsis-like host response and critical illness in COVID-19
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Bermejo-Martin, Jesús F, primary, González-Rivera, Milagros, additional, Almansa, Raquel, additional, Micheloud, Dariela, additional, Domínguez-Gil, Marta, additional, Resino, Salvador, additional, Martín-Fernández, Marta, additional, Murua, Pablo Ryan, additional, Pérez-García, Felipe, additional, Tamayo, Luis, additional, Lopez-Izquierdo, Raúl, additional, Bustamante, Elena, additional, Aldecoa, César, additional, Gómez, José Manuel, additional, Rico-Feijoo, Jesús, additional, Orduña, Antonio, additional, Méndez, Raúl, additional, Natal, Isabel Fernández, additional, Megías, Gregoria, additional, González-Estecha, Montserrat, additional, Carriedo, Demetrio, additional, Doncel, Cristina, additional, Jorge, Noelia, additional, del Campo, Félix, additional, Fernández-Ratero, José Antonio, additional, Trapiello, Wysali, additional, González-Jiménez, Paula, additional, Ruiz, Guadalupe, additional, Kelvin, Alyson A., additional, Ostadgavahi, Ali Toloue, additional, Oneizat, Ruth, additional, Ruiz, Luz María, additional, Miguéns, Iria, additional, Gargallo, Esther, additional, Muñoz, Ioana, additional, Pelegrin, Sara, additional, Martín, Silvia, additional, Olivares, Pablo García, additional, Cedeño, Jamil Antonio, additional, Albi, Tomás Ruiz, additional, Puertas, Carolina, additional, Berezo, Jose Ángel, additional, Renedo, Gloria, additional, Herrán, Rubén, additional, Bustamante-Munguira, Juan, additional, Enríquez, Pedro, additional, Cicuendez, Ramón, additional, Blanco, Jesús, additional, Abadia, Jesica, additional, Barquero, Julia Gómez, additional, Mamolar, Nuria, additional, Blanca-López, Natalia, additional, Valdivia, Luis Jorge, additional, Caso, Belén Fernández, additional, Mantecón, María Ángeles, additional, Motos, Anna, additional, Fernandez-Barat, Laia, additional, Ferrer, Ricard, additional, Barbé, Ferrán, additional, Torres, Antoni, additional, Menéndez, Rosario, additional, Eiros, José María, additional, and Kelvin, David J, additional
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- 2020
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17. Evaluación económica del impacto de la prohibición de plomo en las gasolinas en el cociente intelectual de los niños de 7 y 8 años de la Comunidad de Madrid
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Ordóñez-Iriarte, José M.ª, Guillén-Pérez, José Jesús, Bodas-Pinedo, Andrés, Aparicio-Madre, Manuel Ignacio, Martínez-García, María José, González-Estecha, Montserrat, and Cabasés-Hita, Juan Manuel
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Gasolina ,Disability evaluation ,Plomo ,Evaluación de la discapacidad ,Childood ,Public policy ,Environmental economics ,Test de inteligencia ,Health Impact assessment ,Políticas ambientales ,Environmental pollution ,Evaluación del Impacto en la Salud ,Contaminación ambiental ,Lead ,Niño ,Economía ambiental ,Gasoline - Abstract
Fundamentos: La evaluación económica de las repercusiones sanitarias de las políticas públicas es difícil y escasa. El objetivo del presente estudio fue cuantificar monetariamente los beneficios de la reducción del plomo en la sangre de los niños de 7-8 años en la Comunidad de Madrid (España), derivada de la prohibición del plomo en las gasolinas. Métodos: Se calculó la disminución de puntos de cociente intelectual (CI), utilizando dos estudios realizados en niños de 7 a 8 años según los valores de plomo en sangre que presentaban: media geométrica de 3,8 μg/dL en 1995 y 0,9 μg/dL en 2010. La mejoría neta de CI se midió en términos de capacidad de producción ganada a lo largo de la vida laboral, siguiendo los métodos de Schwartz y Salkiver. Resultados: La reducción de los niveles de plomo en sangre de estos niños evitó perder entre 135.391 y 144.153 puntos de CI. La valoración económica actual de estos puntos en términos de capacidad de producción ganada a lo largo de la vida laboral de estos sujetos se estimó en un rango entre 626,4 y 865,4 millones de euros (valor 2009). Conclusiones: Las cifras de beneficios económicos encontradas derivadas de la medida de prohibición de uso de plomo en las gasolinas son importantes en términos sociales. Background: The repercussions on health of public policies are hard to assess from an economic point of view, which is why this is rarely done. The purpose of this study was to financially quantify the benefits of reducing blood lead levels in children aged 7-8 years in the Community of Madrid (Spain) as a result of the ban on the use of lead in gasoline. Methods: The decrease the intellectual quotient (IQ) points was calculated through two studies on children aged 7-8 years according to their blood lead levels. A geometric mean of 3.8 μg/dl was obtained in the 1995 study and of 0.9 μg/dl in the 2010 study. The net increase in IQ was measured in terms of productivity gained throughout the working life as per the methods of Schwartz and Salkever. Results: The decrease in blood lead levels in these children prevented a loss of between 135,391 and 144,153 IQ points; the current economic valuation of these points in terms of the productivity gained throughout the working life of this cohort of children was estimated to fall within the €626.4m- €865.4m range (2009). Conclusions: The figures of the economic benefits derived from the decision to ban leaded gasoline are very high.
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- 2015
18. [Consensus document on the prevention of exposure to methylmercury in Spain]
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González-Estecha, Montserrat, Bodas-Pinedo, Andrés, Guillén-Pérez, José Jesús, Rubio-Herrera, Miguel Ángel, Martínez-Álvarez, Jesús Román, Herráiz-Martínez, Miguel Ángel, Martell-Claros, Nieves, Ordóñez-Iriarte, José Mª, Sáinz-Martín, María, Farré-Rovira, Rosaura, Martínez-Astorquiza, Txantón, García-Donaire, José Antonio, Calvo-Manuel, Elpidio, Bretón-Lesmes, Irene, Prieto-Menchero, Santiago, Llorente-Ballesteros, María Teresa, Martínez-García, María José, Moreno-Rojas, Rafael, Salas-Salvadó, Jordi, Bermejo-Barrera, Pilar, Cuadrado-Cenzual, María Ángeles, Gallardo-Pino, Carmen, Blanco Fuentes, María, Torres-Moreno, Miriam, Trasobares-Iglesias, Elena M., Barceló Martín, Bernardino, Arroyo-Fernández, Manuel, and Calle-Pascual, Alfonso
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Adult ,Consensus ,Advisory ,Metilmercurio ,Salud ,Methylmercury ,Cost-benefit ,Food Contamination ,Coste-beneficio ,Methylmercury Compounds ,Diet, Mediterranean ,Biomarcadores ,Fish ,Seafood ,Health ,Spain ,Recomendaciones ,Humans ,Child ,Biomarkers ,Pescado - Abstract
Los efectos beneficiosos del consumo de pescado tanto en niños como en adultos han sido bien reconocidos. Sin embargo, la ingesta de metilmercurio principalmente a través del pescado y marisco contaminado puede producir efectos adversos en la salud. El grupo de estudio para la prevención de la exposición al metilmercurio (GEPREM-Hg), constituido por representantes de diferentes sociedades científicas españolas, ha elaborado un documento de consenso donde se recogen en forma de preguntas y respuestas las principales conclusiones, recomendaciones y propuestas planteadas en el grupo. El objetivo del documento es profundizar en el conocimiento de los factores asociados a la exposición al metilmercurio, los posibles efectos sobre la salud en la población española, los métodos de análisis, la interpretación de los resultados, el coste económico y establecer finalmente recomendaciones de consumo de pescados y mariscos. El grupo considera acertadas todas las iniciativas encaminadas a reducir o prohibir el uso del mercurio y la necesidad de conocer los resultados de los análisis de contaminantes que se realizan en los pescados y mariscos que se comercializan en España. Además, opina que se deberían establecer sistemas de biomonitorización para conocer la evolución de la exposición al metilmercurio en niños y adultos y realizar estudios diseñados para conocer los posibles efectos sobre la salud de las concentraciones halladas en la población española, teniendo en cuenta el estilo de vida, los patrones de consumo alimentarios y la dieta mediterránea. The beneficial effects of fish consumption in both children and adults are well known. However, the intake of methylmercury, mainly from contaminated fish and shellfish, can have adverse health effects. The study group on the prevention of exposure to methylmercury (GEPREM-Hg), made up of representatives from different Spanish scientific societies, has prepared a consensus document in a question and answer format, containing the group’s main conclusions, recommendations and proposals. The objective of the document is to provide broader knowledge of factors associated with methylmercury exposure, its possible effects on health among the Spanish population, methods of analysis, interpretation of the results and economic costs, and to then set recommendations for fish and shellfish consumption. The group sees the merit of all initiatives aimed at reducing or prohibiting the use of mercury as well as the need to be aware of the results of contaminant analyses performed on fish and shellfish marketed in Spain. In addition, the group believes that biomonitoring systems should be set up in order to follow the evolution of methylmercury exposure in children and adults and perform studies designed to learn more about the possible health effects of concentrations found in the Spanish population, tacombusking into account the lifestyle, eating patterns and the Mediterranean diet.
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- 2015
19. [Methylmercury: existing recommendations; methods of analysing and interpreting the results; economic evaluation]
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González-Estecha, Montserrat, Bodas-Pinedo, Andrés, Martínez-García, María José, Trasobares-Iglesias, Elena M., Bermejo-Barrera, Pilar, Ordóñez-Iriarte, José María, Llorente-Ballesteros, María Teresa, Prieto-Menchero, Santiago, Guillén-Pérez, José Jesús, Martell-Claros, Nieves, Cuadrado-Cenzual, María Ángeles, Rubio-Herrera, Miguel Ángel, Martínez-Álvarez, Jesús Román, Calvo-Manuel, Elpidio, Farré-Rovira, Rosaura, Herráiz-Martínez, Miguel Ángel, Bretón Lesmes, Irene, García-Donaire, José Antonio, Sáinz-Martín, María, Martínez-Astorquiza, Txantón, Gallardo-Pino, Carmen, Moreno-Rojas, Rafael, Salas-Salvadó, Jordi, Blanco Fuentes, María, Arroyo-Fernández, Manuel, and Calle Pascual, Alfonso
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Terapia quelante ,Advisory ,Cost-Benefit Analysis ,Metilmercurio ,Fishes ,Methylmercury ,Cost-benefit ,Food Contamination ,Coste-beneficio ,Methylmercury Compounds ,Chelation Therapy ,Biomarcadores ,Fish ,Recomendaciones ,Animals ,Humans ,Biomarkers ,Pescado - Abstract
Los efectos beneficiosos del consumo de pescado son bien reconocidos. Sin embargo, existe preocupación a nivel mundial sobre los niveles de metilmercurio en el pescado, por lo que muchos países como Estados Unidos, Australia, Nueza Zelanda, Canadá y muchos países europeos han realizado recomendaciones de consumo de pescado a la población , especialmente a los grupos vulnerables con el fin de reducir la ingesta de metilmercurio. La sangre y el pelo son las mejores muestras biológicas para medir el metilmercurio. El método de análisis más empleado ha sido la espectroscopia de absorción atómica con la técnica del vapor frío, aunque existen también métodos directos que se basan en la descomposición térmica de la muestra. En los últimos años han aumentado los laboratorios que miden el mercurio por espectrometría de masas con plasma acoplado por inducción. Además, se puede diferenciar las distintas especies de mercurio acoplando métodos de separación cromatográficos. Es necesario que los laboratorios que analizan mercurio en muestras biológicas participen en programas de garantía externa de la calidad. Aunque se logre reducir las emisiones de mercurio, el mercurio del medio ambiente altodavía puede permanecer muchos años, por lo que es fundamental el consejo dietético para disminuir la exposición. No es aconsejable el uso de terapia quelante con fines diagnósticos o en pacientes asintomáticos. Es preciso proponer medidas de salud pública encaminadas a la disminución de la exposición al mercurio y que se evalúe también los beneficios de las mismas desde el punto de vista económico y social. The beneficial effects of fish consumption are well- known. Nevertheless, there is worldwide concern regard methylmercury concentrations in fish, which is why many countries such as the United States, Australia, New Zealand, Canada and numerous European countries have made fish consumption recommendations for their populations, particularly vulnerable groups, in order to México methylmercury intake. Blood and hair are the best biological samples for measuring methylmercury. The most widely-used method to analyse methylmercury is cold vapor atomic absorption spectrometry, although there are also direct methods based on the thermal decomposition of the sample. In recent years, the number of laboratories that measure mercury by inductively coupled plasma mass spectrometry has increased. In addition, the different kinds of mercury can be distinguished by coupling chromatography methods of separation. Laboratories that analyse mercury in biological samples need to participate in external quality control programmes. Even if mercury emissions are reduced, mercury may remain in the environment for many years, so dietary recommendations are fundamental in order to reduce exposure. It is necessary to propose public health measures aimed at decreasing mercury exposure and to evaluate the benefits of such measures from the economic and social standpoints.
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- 2015
20. [The effects of methylmercury on health in children and adults; national and international studies]
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González-Estecha, Montserrat, Bodas-Pinedo, Andrés, Rubio-Herrera, Miguel Ángel, Martell-Claros, Nieves, Trasobares-Iglesias, Elena M., Ordóñez-Iriarte, José M.ª, Guillén-Pérez, José Jesús, Herráiz-Martínez, Miguel Ángel, García-Donaire, José Antonio, Farré-Rovira, Rosaura, Calvo-Manuel, Elpidio, Martínez-Álvarez, Jesús Román, Llorente-Ballesteros, M.ª Teresa, Sáinz-Martín, María, Martínez-Astorquiza, Txantón, Martínez-García, M.ª José, Bretón Lesmes, Irene, Cuadrado-Cenzual, M.ª Ángeles, Prieto-Menchero, Santiago, Gallardo-Pino, Carmen, Moreno-Rojas, Rafael, Bermejo-Barrera, Pilar, Torres-Moreno, Miriam, Arroyo-Fernández, Manuel, and Calle-Pascual, Alfonso
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Adult ,Metilmercurio ,Enfermedad cardiovascular ,Neurodevelopment ,Fishes ,Infant, Newborn ,Infant ,Salud ,Neurodesarrollo ,Methylmercury ,Methylmercury Compounds ,Cardiovascular diseases ,Seafood ,Health ,Pregnancy ,Prenatal exposure ,Mercury Poisoning ,Exposición prenatal ,Animals ,Humans ,Female - Abstract
Los efectos beneficiosos del consumo de pescado tanto en niños como en adultos han sido bien reconocidos. Sin embargo, se ha referido que la ingesta excesiva de metilmercurio procedente del pescado contaminado produce toxicidad neurológica en los niños afectando a la función cognitiva, la memoria, la función visual-motora y al lenguaje. Después de las intoxicaciones de Minamata e Iraq, se realizaron grandes estudios epidemiológicos en Nueva Zelanda, las islas Féroe y las islas Seychelles y se establecieron recomendaciones internacionales sobre el consumo de pescado y marisco en las mujeres embarazadas y niños pequeños. En España, el proyecto Infancia y Medio Ambiente (INMA) ha estudiado los efectos del medio ambiente y de la dieta sobre el desarrollo fetal e infantil en diversas zonas geográficas de España. Los estudios realizados nacionales e internacionales muestran que la concentración de mercurio depende principalmente del consumo de pescado, aunque existe una variabilidad entre los países que podría explicarse no solo por la cantidad de pescado consumida, sino también por el tipo o especies de pescados que se consumen, así como por otro tipo de factores. Aunque los efectos perjudiciales del metilmercurio mejor documentados son los que se producen sobre el desarrollo del sistema nervioso en el feto y en el recién nacido, cada vez hay más estudios que indican que también puede afectar a la función cognitiva, reproducción y especialmente al riesgo cardiovascular en la población adulta. Sin embargo, son necesarios más estudios para confirmarlo y establecer la existencia de una relación causal. The benefit of fish consumption in children and adults is well-known. However, it has been pointed out that excessive methylmercury intake due to consumption of contaminated fish leads to neurological toxicity in children, affecting cognitive function, memory, visual-motor function and language. After the intoxications in Minamata and Iraq, wide-ranging epidemiological studies were carried out in New Zealand, the Faroe Islands and the Seychelles and international recommendations were established for fish consumption in pregnant women and small children. In Spain, the Childhood and Environmental project (INMA, its Spanish acronym) has studied the effects of diet and the environment on fetal and childhood development in different geographic areas of Spain. National and international sudies have demonstrated that mercury concentrations are mainly dependent on fish consumption, although there are variations among countries which can be explained not only by the levels of fish consumption, but also by the type or species of fish that is consumed, as well as other factors. Although the best documented adverse effects of methylmercury are the effects on nervous sytem development in fetuses and newborns, an increasing number of studies indicate that cognitive function, reproduction and, especially, cardiovascular risk in the adult population can also be affected. However, more studies are necessary in order to confirm this and establish the existance of a causal relationship.
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- 2014
21. Evaluación económica del impacto de la prohibición de plomo en las gasolinas en el cociente intelectual de los niños de 7 y 8 años de la Comunidad de Madrid
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Ordóñez-Iriarte, José M.ª, primary, Guillén-Pérez, José Jesús, additional, Bodas-Pinedo, Andrés, additional, Aparicio-Madre, Manuel Ignacio, additional, Martínez-García, María José, additional, González-Estecha, Montserrat, additional, and Cabasés-Hita, Juan Manuel, additional
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- 2015
- Full Text
- View/download PDF
22. Procedimiento de validación de un método para cuantificar mercurio en sangre por espectroscopía de absorción atómica con descomposición térmica y amalgamación
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Palazón Bru, Irene, primary, González-Estecha, Montserrat, additional, and Arroyo Fernández, Manuel, additional
- Published
- 2015
- Full Text
- View/download PDF
23. Procedimiento de validación de un método para cuantificar cobalto en suero por espectroscopia de absorción atómica con atomización electrotérmica
- Author
-
López Lozano, Lorena, primary, Palazón Bru, Irene, additional, Palazón Bru, Antonio, additional, Arroyo Fernández, Manuel, additional, and González-Estecha, Montserrat, additional
- Published
- 2015
- Full Text
- View/download PDF
24. Procedimiento de validación de un método para cuantificar cromo en suero por espectroscopía de absorción atómica con atomización electrotérmica
- Author
-
Palazón Bru, Irene, primary, López Lozano, Lorena, additional, Palazón Bru, Antonio, additional, Arroyo Fernández, Manuel, additional, and González-Estecha, Montserrat, additional
- Published
- 2015
- Full Text
- View/download PDF
25. Documento de consenso sobre la prevención de la exposición al metilmercurio en España.
- Author
-
González-Estecha, Montserrat, Bodas-Pinedo, Andrés, Guillén-Pérez, José Jesús, Rubio-Herrera, Miguel Ángel, Martínez-Álvarez, Jesús Román, Herráiz-Martínez, Miguel Ángel, Martell-Claros, Nieves, Ordóñez-Iriarte, José Ma, Sáinz-Martín, María, Farré-Rovira, Rosaura, Martínez-Astorquiza, Txantón, García-Donaire, José Antonio, Calvo-Manuel, Elpidio, Bretón-Lesmes, Irene, Prieto-Menchero, Santiago, Llorente-Ballesteros, María Teresa, Martínez-García, María José, Moreno-Rojas, Rafael, Salas-Salvadó, Jordi, and Bermejo-Barrera, Pilar
- Subjects
- *
METHYLMERCURY , *MERCURY content of fish , *SPANIARDS , *BIOMARKERS , *COST effectiveness , *HEALTH , *PHYSIOLOGY - Abstract
The beneficial effects of fish consumption in both children and adults are well known. However, the intake of methylmercury, mainly from contaminated fish and shellfish, can have adverse health effects. The study group on the prevention of exposure to methylmercury (GEPREM-Hg), made up of representatives from different Spanish scientific societies, has prepared a consensus document in a question and answer format, containing the group's main conclusions, recommendations and proposals. The objective of the document is to provide broader knowledge of factors associated with methylmercury exposure, its possible effects on health among the Spanish population, methods of analysis, interpretation of the results and economic costs, and to then set recommendations for fish and shellfish consumption. The group sees the merit of all initiatives aimed at reducing or prohibiting the use of mercury as well as the need to be aware of the results of contaminant analyses performed on fish and shellfish marketed in Spain. In addition, the group believes that biomonitoring systems should be set up in order to follow the evolution of methylmercury exposure in children and adults and perform studies designed to learn more about the possible health effects of concentrations found in the Spanish population, taking into account the lifestyle, eating patterns and the Mediterranean diet. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
26. Metilmercurio: Recomendaciones existentes; métodos de análisis e interpretación de resultados; evaluación económica.
- Author
-
González-Estecha, Montserrat, Bodas-Pinedo, Andrés, Martínez-García, María José, Trasobares-Iglesias, Elena M., Bermejo-Barrera, Pilar, Ordóñez-Iriarte, José María, Llorente-Ballesteros, María Teresa, Prieto-Menchero, Santiago, Guillén-Pérez, José Jesús, Martell-Claros, Nieves, Cuadrado-Cenzual, María Ángeles, Rubio-Herrera, Miguel Ángel, Martínez-Álvarez, Jesús Román, Calvo-Manuel, Elpidio, Farré-Rovira, Rosaura, Herráiz-Martínez, Miguel Ángel, Bretón Lesmes, Irene, García-Donaire, José Antonio, Sáinz-Martín, María, and Martínez-Astorquiza, Txantón
- Subjects
- *
METHYLMERCURY , *ECONOMICS , *MERCURY content of fish , *BIOMARKERS , *COST effectiveness , *CHELATION therapy - Abstract
The beneficial effects of fish consumption are well-known. Nevertheless, there is worldwide concern regard methylmercury concentrations in fish, which is why many countries such as the United States, Australia, New Zealand, Canada and numerous European countries have made fish consumption recommendations for their populations, particularly vulnerable groups, in order to México methylmercury intake. Blood and hair are the best biological samples for measuring methylmercury. The most widely-used method to analyse methylmercury is cold vapor atomic absorption spectrometry, although there are also direct methods based on the thermal decomposition of the sample. In recent years, the number of laboratories that measure mercury by inductively coupled plasma mass spectrometry has increased. In addition, the different kinds of mercury can be distinguished by coupling chromatography methods of separation. Laboratories that analyse mercury in biological samples need to participate in external quality control programmes. Even if mercury emissions are reduced, mercury may remain in the environment for many years, so dietary recommendations are fundamental in order to reduce exposure. It is necessary to propose public health measures aimed at decreasing mercury exposure and to evaluate the benefits of such measures from the economic and social standpoints. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
27. Efectos sobre la salud del metilmercurio en niños y adultos; estudios nacionales e internacionales.
- Author
-
González-Estecha, Montserrat, Bodas-Pinedo, Andrés, Rubio-Herrera, Miguel Ángel, Martell-Claros, Nieves, Trasobares-Iglesias, Elena M., Ordóñez-Iriarte, José Ma, Guillen-Pérez, José Jesús, Herráiz-Martínez, Miguel Ángel, García-Donaire, José Antonio, Farré-Rovira, Rosaura, Calvo-Manuel, Elpidio, Martínez-Álvarez, Jesús Román, Llorente-Ballesteros, Ma Teresa, Sáinz-Martín, María, Martínez-Astorquiza, Txantón, Martínez-García, Ma José, Bretón Lesmes, Irene, Cuadrado-Cenzual, Ma Ángeles, Prieto-Menchero, Santiago, and Gallardo-Pino, Carmen
- Subjects
- *
PHYSIOLOGICAL effects of methylmercury compounds , *METHYLMERCURY , *CHILDREN'S health , *CARDIOVASCULAR diseases , *PRENATAL exposure delayed effects , *FISH research - Abstract
The benefit of fish consumption in children and adults is well-known. However, it has been pointed out that excessive methylmercury intake due to consumption of contaminated fish leads to neurological toxicity in children, affecting cognitive function, memory, visual-motor function and language. After the intoxications in Minamata and Iraq, wide-ranging epidemiological studies were carried out in New Zealand, the Faroe Islands and the Seychelles and international recommendations were established for fish consumption in pregnant women and small children. In Spain, the Childhood and Environmental project (INMA, its Spanish acronym) has studied the effects of diet and the environment on fetal and childhood development in different geographic areas of Spain. National and international sudies have demonstrated that mercury concentrations are mainly dependent on fish consumption, although there are variations among countries which can be explained not only by the levels of fish consumption, but also by the type or species of fish that is consumed, as well as other factors. Although the best documented adverse effects of methylmercury are the effects on nervous sytem development in fetuses and newborns, an increasing number of studies indicate that cognitive function, reproduction and, especially, cardiovascular risk in the adult population can also be affected. However, more studies are necessary in order to confirm this and establish the existance of a causal relationship. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
28. Exposición al metilmercurio en la población general; toxicocinética; diferencias según el sexo, factores nutricionales y genéticos.
- Author
-
González-Estecha, Montserrat, Bodas-Pinedo, Andrés, Guillén-Pérez, José Jesús, Rubio-Herrera, Miguel Ángel, Ordóñez-Iriarte, José Ma, Trasobares-Iglesias, Elena M., Martell-Claros, Nieves, Martínez-Álvarez, Jesús Román, Farré-Rovira, Rosaura, Herráiz-Martínez, Miguel Angel, Martínez-Astorquiza, Txantón, Calvo-Manuel, Elpidio, Sáinz-Martín, María, Bretón-Lesmes, Irene, Prieto-Menchero, Santiago, Llorente-Ballesteros, Ma Teresa, Martínez-García, Ma José, Salas-Salvadó, Jordi, Bermejo-Barrera, Pilar, and García-Donaire, José Antonio
- Subjects
- *
METHYLMERCURY , *TOXINS , *GENDER studies , *NUTRITION , *GENETICS , *MERCURY in the body , *UNSATURATED fatty acids - Abstract
Mercury is an environmental toxicant that causes numerous adverse effects on human health and natural ecosystems. The factors that determine the existance of adverse effects, as well as their severity are, among others: the chemical form of mercury (elemental, inorganic, organic), dosis, age, period of exposure, pathways of exposure and environmental, nutritional and genetic factors. In the aquatic cycle of mercury, once it has been deposited, it is transformed into methylmercury due to the action of certain sulphate-reducing bacteria, which bioaccumulates in the aquatic organisms and moves into the food chain. The methylmercury content of large, long-lived fish such as swordfish, shark, tuna or marlin, is higher. Methylmercury binds to protein in fish and is therefore not eliminated by cleaning or cooking the fish. Fetuses and small children are more vulnerable to the neurotoxic effects of methylmercury from the consumption of contaminated fish. Methylmercury is absorbed in the gastrointestinal tract and crosses the blood-brain barrier and the placenta. The intake of certain dietary components such as polyunsaturated fatty acids, selenium, fiber, thiol compounds, certain phytochemicals and other nutrients can modify methylmercury bioaccesibility and its toxicity. Apart from environmental factors, genetic factors can influence mercury toxicity and explain part of the individual vulnerability. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
29. Asociación entre la concentración sérica de selenio y el perfil lipídico en una población infantil y adulta
- Author
-
Palazón Bru, Irene, González Estecha, Montserrat, Bodas Pinedo, Andrés, and Calvo Manuel, Elpidio
- Subjects
Medicina - Abstract
El selenio es un elemento traza que se encuentra en el medio ambiente y que desempeña funciones primordiales en el organismo humano. El selenio se encuentra en el medioambiente en la mayoría de rocas y suelos. Otras fuentes ambientales importantes de selenio son la combustión del carbón, las erupciones volcánicas y las prácticas agrícolas. El selenio es un elemento traza esencial porque forma parte de múltiples proteínas importantes, concretamente de enzimas implicadas en mecanismos de defensa antioxidantes, en el metabolismo de hormonas tiroideas y en el control redox de reacciones intracelulares. Sin embargo, a pesar de ser un elemento esencial, la exposición a dosis altas a través de la inhalación o ingestión puede producir efectos adversos en la salud. El mecanismo por el cual el selenio produce dichos efectos es desconocido, aunque se han sugerido diferentes teorías. Las principales fuentes de selenio en la población general son la dieta, el agua y los suplementos alimenticios. Diversos estudios han demostrado que el déficit de selenio se asocia con un aumento de mortalidad y de riesgo de cáncer. Sin embargo, otros estudios han señalado efectos adversos en poblaciones con altos niveles de selenio...
- Published
- 2016
30. Analytical performance specifications for trace elements in biological fluids derived from six countries federated external quality assessment schemes over 10 years.
- Author
-
Arnaud J, Weykamp C, Wenzel R, Patriarca M, González-Estecha M, Janssen L, Fofou-Caillierez MB, Alemany MV, Patriarca V, de Graaf I, Persoons R, Panadès M, China B, Winkel MT, van der Vuurst H, and Thelen M
- Abstract
Objectives: This article defines analytical performance specifications (APS) for evaluating laboratory proficiency through an external quality assessment scheme., Methods: Standard deviations for proficiency assessment were derived from Thompson's characteristic function applied to robust data calculated from participants' submissions in the Occupational and Environmental Laboratory Medicine (OELM) external quality assurance scheme for trace elements in serum, whole blood and urine. Characteristic function was based on two parameters: (1) β - the average coefficient of variation (CV) at high sample concentrations; (2) α - the average standard deviation (SD) at low sample concentrations. APSs were defined as 1.65 standard deviations calculated by Thompson's approach. Comparison between OELM robust data and characteristic function were used to validate the model., Results: Application of the characteristic function allowed calculated APS for 18 elements across three matrices. Some limitations were noted, particularly for elements (1) with no sample concentrations near analytical technique limit of detection; (2) exhibiting high robust CV at high concentration; (3) exhibiting high analytical variability such as whole blood Tl and urine Pb; (4) with an unbalanced number of robust SD above and under the characteristic function such as whole blood Mn and serum Al and Zn., Conclusions: The characteristic function was a useful means of deriving APS for trace elements in biological fluids where biological variation data or outcome studies were not available. However, OELM external quality assurance scheme data suggests that the characteristic functions are not appropriate for all elements., (© 2024 Walter de Gruyter GmbH, Berlin/Boston.)
- Published
- 2024
- Full Text
- View/download PDF
31. [Economic Appraisal of the Impact of the Ban on the Use of Lead in Gasoline on the Intellectual Quotient of 7-8 Years Old in the Community of Madrid].
- Author
-
Ordóñez-Iriarte JM, Guillén-Pérez JJ, Bodas-Pinedo A, Aparicio-Madre MI, Martínez-García MJ, González-Estecha M, and Cabasés-Hita JM
- Subjects
- Child, Cross-Sectional Studies, Efficiency, Employment economics, Environmental Exposure economics, Environmental Exposure legislation & jurisprudence, Female, Health Impact Assessment, Health Policy legislation & jurisprudence, Humans, Intelligence Tests, Male, Spain, Environmental Exposure prevention & control, Environmental Pollutants blood, Environmental Pollutants toxicity, Gasoline, Health Policy economics, Intelligence, Lead blood, Lead toxicity
- Abstract
Background: The repercussions on health of public policies are hard to assess from an economic point of view, which is why this is rarely done. The purpose of this study was to financially quantify the benefits of reducing blood lead levels in children aged 7-8 years in the Community of Madrid (Spain) as a result of the ban on the use of lead in gasoline., Methods: The decrease the intellectual quotient (IQ) points was calculated through two studies on children aged 7-8 years according to their blood lead levels. A geometric mean of 3.8 μg/dl was obtained in the 1995 study and of 0.9 μg/dl in the 2010 study. The net increase in IQ was measured in terms of productivity gained throughout the working life as per the methods of Schwartz and Salkever., Results: The decrease in blood lead levels in these children prevented a loss of between 135,391 and 144,153 IQ points; the current economic valuation of these points in terms of the productivity gained throughout the working life of this cohort of children was estimated to fall within the 626.4m- 865.4m range (2009)., Conclusions: The figures of the economic benefits derived from the decision to ban leaded gasoline are very high.
- Published
- 2015
- Full Text
- View/download PDF
32. [Consensus document on the prevention of exposure to methylmercury in Spain].
- Author
-
González-Estecha M, Bodas-Pinedo A, Guillén-Pérez JJ, Rubio-Herrera MÁ, Martínez-Álvarez JR, Herráiz-Martínez MÁ, Martell-Claros N, Ordóñez-Iriarte JM, Sáinz-Martín M, Farré-Rovira R, Martínez-Astorquiza T, García-Donaire JA, Calvo-Manuel E, Bretón-Lesmes I, Prieto-Menchero S, Llorente-Ballesteros MT, Martínez-García MJ, Moreno-Rojas R, Salas-Salvadó J, Bermejo-Barrera P, Cuadrado-Cenzual MÁ, Gallardo-Pino C, Blanco Fuentes M, Torres-Moreno M, Trasobares-Iglesias EM, Barceló Martín B, Arroyo-Fernández M, and Calle-Pascual A
- Subjects
- Adult, Child, Consensus, Diet, Mediterranean, Food Contamination analysis, Humans, Spain epidemiology, Methylmercury Compounds adverse effects, Methylmercury Compounds analysis, Seafood adverse effects, Seafood analysis
- Abstract
The beneficial effects of fish consumption in both children and adults are well known. However, the intake of methylmercury, mainly from contaminated fish and shellfish, can have adverse health effects. The study group on the prevention of exposure to methylmercury (GEPREM-Hg), made up of representatives from different Spanish scientific societies, has prepared a consensus document in a question and answer format, containing the group's main conclusions, recommendations and proposals. The objective of the document is to provide broader knowledge of factors associated with methylmercury exposure, its possible effects on health among the Spanish population, methods of analysis, interpretation of the results and economic costs, and to then set recommendations for fish and shellfish consumption. The group sees the merit of all initiatives aimed at reducing or prohibiting the use of mercury as well as the need to be aware of the results of contaminant analyses performed on fish and shellfish marketed in Spain. In addition, the group believes that biomonitoring systems should be set up in order to follow the evolution of methylmercury exposure in children and adults and perform studies designed to learn more about the possible health effects of concentrations found in the Spanish population, ta king into account the lifestyle, eating patterns and the Mediterranean diet., (Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
33. [Methylmercury: existing recommendations; methods of analysing and interpreting the results; economic evaluation].
- Author
-
González-Estecha M, Bodas-Pinedo A, Martínez-García MJ, Trasobares-Iglesias EM, Bermejo-Barrera P, Ordóñez-Iriarte JM, Llorente-Ballesteros MT, Prieto-Menchero S, Guillén-Pérez JJ, Martell-Claros N, Cuadrado-Cenzual MÁ, Rubio-Herrera MÁ, Martínez-Álvarez JR, Calvo-Manuel E, Farré-Rovira R, Herráiz-Martínez MÁ, Bretón Lesmes I, García-Donaire JA, Sáinz-Martín M, Martínez-Astorquiza T, Gallardo-Pino C, Moreno-Rojas R, Salas-Salvadó J, Blanco Fuentes M, Arroyo-Fernández M, and Calle Pascual A
- Subjects
- Animals, Cost-Benefit Analysis, Fishes, Food Contamination analysis, Food Contamination economics, Humans, Methylmercury Compounds economics, Methylmercury Compounds analysis, Methylmercury Compounds toxicity
- Abstract
The beneficial effects of fish consumption are well- known. Nevertheless, there is worldwide concern regard methylmercury concentrations in fish, which is why many countries such as the United States, Australia, New Zealand, Canada and numerous European countries have made fish consumption recommendations for their populations, particularly vulnerable groups, in order to México methylmercury intake. Blood and hair are the best biological samples for measuring methylmercury. The most widely-used method to analyse methylmercury is cold vapor atomic absorption spectrometry, although there are also direct methods based on the thermal decomposition of the sample. In recent years, the number of laboratories that measure mercury by inductively coupled plasma mass spectrometry has increased. In addition, the different kinds of mercury can be distinguished by coupling chromatography methods of separation. Laboratories that analyse mercury in biological samples need to participate in external quality control programmes. Even if mercury emissions are reduced, mercury may remain in the environment for many years, so dietary recommendations are fundamental in order to reduce exposure. It is necessary to propose public health measures aimed at decreasing mercury exposure and to evaluate the benefits of such measures from the economic and social standpoints., (Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
34. [Methylmercury exposure in the general population; toxicokinetics; differences by gender, nutritional and genetic factors].
- Author
-
González-Estecha M, Bodas-Pinedo A, Guillén-Pérez JJ, Rubio-Herrera MÁ, Ordóñez-Iriarte JM, Trasobares-Iglesias EM, Martell-Claros N, Martínez-Álvarez JR, Farré-Rovira R, Herráiz-Martínez MÁ, Martínez-Astorquiza T, Calvo-Manuel E, Sáinz-Martín M, Bretón-Lesmes I, Prieto-Menchero S, Llorente-Ballesteros MT, Martínez-García MJ, Salas-Salvadó J, Bermejo-Barrera P, García-Donaire JA, Cuadrado-Cenzual MÁ, Gallardo-Pino C, Moreno-Rojas R, Arroyo-Fernández M, and Calle-Pascual A
- Subjects
- Aging, Animals, Female, Fishes, Humans, Male, Mercury metabolism, Mercury pharmacokinetics, Seafood, Sex Characteristics, Toxicokinetics, Mercury Poisoning genetics, Mercury Poisoning pathology, Methylmercury Compounds pharmacokinetics, Methylmercury Compounds toxicity, Nutritional Status
- Abstract
Mercury is an environmental toxicant that causes numerous adverse effects on human health and natural ecosystems. The factors that determine the existance of adverse effects, as well as their severity are, among others: the chemical form of mercury (elemental, inorganic, organic), dosis, age, period of exposure, pathways of exposure and environmental, nutritional and genetic factors. In the aquatic cycle of mercury, once it has been deposited, it is transformed into methylmercury due to the action of certain sulphate-reducing bacteria, which bioaccumulates in the aquatic organisms and moves into the food chain. The methylmercury content of large, long-lived fish such as swordfish, shark, tuna or marlin, is higher. Methylmercury binds to protein in fish and is therefore not eliminated by cleaning or cooking the fish. Fetuses and small children are more vulnerable to the neurotoxic effects of methylmercury from the consumption of contaminated fish. Methylmercury is absorbed in the gastrointestinal tract and crosses the blood-brain barrier and the placenta. The intake of certain dietary components such as polyunsaturated fatty acids, selenium, fiber, thiol compounds, certain phytochemicals and other nutrients can modify methylmercury bioaccesibility and its toxicity. Apart from environmental factors, genetic factors can influence mercury toxicity and explain part of the individual vulnerability., (Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
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