8 results on '"Girotti, G."'
Search Results
2. The Association Between Bone Mineral Density and Airflow Limitation in a Cohort of Fit Elderly Women
- Author
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Trevisan, Caterina, Vianello, A., Veronese, N., Carraro, S., Pizzato, S., Lucato, P., Girotti, G., Rinaldo, C., Coin, A., Manzato, E., and Sergi, G.
- Subjects
Bone density -- Physiological aspects -- Research ,Elderly women -- Physiological aspects -- Research ,Lung diseases -- Risk factors -- Demographic aspects -- Research ,Health - Abstract
Purpose As studies examining the association between bone mineral density (BMD) and airflow limitation (AL) have produced conflicting results, the current one set out to analyze if and to what degree there are any correlations between these variables in a population of fit elderly women. Methods One hundred and twenty-one non-smoking, fit and healthy women (age [greater than or equal to] 65 years) underwent anthropometric assessment, laboratory testing (serum 25-hydroxy vitamin D, parathormone, and cytokine levels), pulmonary function testing (PFT), and dual-energy X-ray absorptiometry to evaluate BMD values of the lumbar and femoral regions. Results A significant positive association was found between FEV.sub.1/FVC ratio (Tiffeneau index), a sensitive index of AL, and lumbar and femoral BMD; a 10 % increase in the FEV.sub.1/FVC ratio resulted in a significant increase of 0.025 g/cm.sup.2 in the total hip (p = 0.05), 0.027 g/cm.sup.2 in the femoral neck (p = 0.02), 0.028 g/cm.sup.2 in the femoral trochanter (p = 0.01), and 0.047 g/cm.sup.2 in the lumbar (p = 0.03) BMDs. Binary logistic analyses demonstrated more than a threefold higher risk of low BMD values for the lowest FEV.sub.1/FVC quartile in the lumbar (OR 4.62, 95 % CI 1.48-14.40, p = 0.008), total hip (OR 4.09, 95 % CI 1.28-13.05, p = 0.02 for the second quartile), and femoral trochanter regions (OR 3.90, 95 % CI 1.25-12.20, p = 0.02 for the third quartile). Conclusions AL was associated with a higher risk of reduced BMD in healthy, fit elderly women., Author(s): Caterina Trevisan[sup.1] , A. Vianello[sup.2] , N. Veronese[sup.1] , S. Carraro[sup.1] , S. Pizzato[sup.1] , P. Lucato[sup.1] , G. Girotti[sup.1] , C. Rinaldo[sup.2] , A. Coin[sup.1] , E. Manzato[sup.1] [...]
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- 2016
- Full Text
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3. Nephrolithiasis, bone mineral density, osteoporosis, and fractures: a systematic review and comparative meta-analysis
- Author
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Lucato, P., Trevisan, C., Stubbs, B., Zanforlini, B. M., Solmi, M., Luchini, C., Girotti, G., Pizzato, S., Manzato, E., Sergi, G., Giannini, S., Fusaro, M., and Veronese, N.
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- 2016
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4. Duration of breastfeeding as a risk factor for vertebral fractures
- Author
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Bolzetta, F., Veronese, N., De Rui, M., Berton, L., Carraro, S., Pizzato, S., Girotti, G., De Ronch, I., Manzato, E., Coin, A., and Sergi, G.
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- 2014
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5. Nephrolithiasis, bone mineral density, osteoporosis, and fractures: a systematic review and comparative meta-analysis
- Author
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Brendon Stubbs, G. Girotti, Maria Fusaro, S. Pizzato, G. Sergi, Sandro Giannini, Paola Lucato, Marco Solmi, Nicola Veronese, Bruno Micael Zanforlini, Enzo Manzato, Claudio Luchini, Caterina Trevisan, Lucato, P., Trevisan, C., Stubbs, B., Zanforlini, B.M., Solmi, M., Luchini, C., Girotti, G., Pizzato, S., Manzato, E., Sergi, G., Giannini, S., Fusaro, M., and Veronese, N.
- Subjects
Adult ,medicine.medical_specialty ,Bone mineral density, Fractures, Kidney stone, Nephrolithiasis, Osteoporosis ,Endocrinology, Diabetes and Metabolism ,Osteoporosis ,030232 urology & nephrology ,030209 endocrinology & metabolism ,Bone mineral density ,Fractures ,Kidney stone ,Nephrolithiasis ,NO ,03 medical and health sciences ,Fractures, Bone ,0302 clinical medicine ,Bone Density ,Risk Factors ,Internal medicine ,medicine ,Humans ,Femoral neck ,Bone mineral ,business.industry ,Hazard ratio ,medicine.disease ,Confidence interval ,Rheumatology ,medicine.anatomical_structure ,Meta-analysis ,Orthopedic surgery ,business - Abstract
Summary: Our meta-analysis demonstrates that people with nephrolithiasis have decreased bone mineral density, an increased odds of osteoporosis, and potentially an elevated risk of fractures. Introduction: People with nephrolithiasis might be at risk of reduced bone mineral density (BMD) and fractures, but the data is equivocal. We conducted a meta-analysis to investigate if patients with nephrolithiasis have worse bone health outcomes (BMD), osteoporosis, and fractures versus healthy controls (HCs). Methods: Two investigators searched major databases for articles reporting BMD (expressed as g/cm2 or a T- or Z-score), osteoporosis or fractures in a sample of people with nephrolithiasis, and HCs. Standardized mean differences (SMDs), 95% confidence intervals (CIs) were calculated for BMD parameters; in addition odds (ORs)for case-control and adjusted hazard ratios (HRs) in longitudinal studies for categorical variables were calculated. Results: From 1816 initial hits, 28 studies were included. A meta-analysis of case-control studies including 1595 patients with nephrolithiasis (mean age 41.1years) versus 3402 HCs (mean age 40.2years) was conducted. Patients with nephrolithiasis showed significant lower T-scores values for the spine (seven studies; SMD = −0.69; 95% CI = −0.86 to −0.52; I2 = 0%), total hip (seven studies; SMD = −0.82; 95% CI = −1.11 to −0.52; I2 = 72%), and femoral neck (six studies; SMD = −0.67; 95% CI = −−1.00 to −0.34; I2 = 69%). A meta-analysis of thecase-controlled studies suggests that people with nephrolithiasis are at increased risk of fractures (OR = 1.15, 95% CI = 1.12–1.17, p < 0.0001, studies = 4), while the risk of fractures in two longitudinal studies demonstrated trend level significance (HR = 1.31, 95% CI = 0.95–1.62). People with nephrolithiasis were four times more likely to have osteoporosis than HCs (OR = 4.12, p < 0.0001). Conclusions: Nephrolithiasis is associated with lower BMD, an increased risk of osteoporosis, and possibly, fractures. Future screening/preventative interventions targeting bone health might be indicated. © 2016, International Osteoporosis Foundation and National Osteoporosis Foundation.
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- 2016
6. The Association Between Bone Mineral Density and Airflow Limitation in a Cohort of Fit Elderly Women
- Author
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Andrea Vianello, Caterina Trevisan, S. Carraro, S. Pizzato, G. Sergi, Nicola Veronese, Enzo Manzato, Paola Lucato, G. Girotti, Alessandra Coin, Claudia Rinaldo, Trevisan, C., Vianello, A., Veronese, N., Carraro, S., Pizzato, S., Lucato, P., Girotti, G., Rinaldo, C., Coin, A., Manzato, E., and Sergi, G.
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Vital Capacity ,Population ,030209 endocrinology & metabolism ,NO ,03 medical and health sciences ,FEV1/FVC ratio ,Absorptiometry, Photon ,0302 clinical medicine ,Lumbar ,Elderly ,Airflow limitation ,Bone Density ,Forced Expiratory Volume ,Internal medicine ,medicine ,Bone mineral density ,Humans ,education ,Aged ,Femoral neck ,Bone mineral ,education.field_of_study ,Lumbar Vertebrae ,Trochanter ,Pulmonary function test ,Femur Neck ,business.industry ,Pulmonary function test, Airflow limitation, Bone mineral density, Elderly ,Anthropometry ,Healthy Volunteers ,Surgery ,medicine.anatomical_structure ,030228 respiratory system ,Quartile ,Physical Fitness ,Female ,business - Abstract
Purpose: As studies examining the association between bone mineral density (BMD) and airflow limitation (AL) have produced conflicting results, the current one set out to analyze if and to what degree there are any correlations between these variables in a population of fit elderly women. Methods: One hundred and twenty-one non-smoking, fit and healthy women (age≥65years) underwent anthropometric assessment, laboratory testing (serum 25-hydroxy vitamin D, parathormone, and cytokine levels), pulmonary function testing (PFT), and dual-energy X-ray absorptiometry to evaluate BMD values of the lumbar and femoral regions. Results: A significant positive association was found between FEV1/FVC ratio (Tiffeneau index), a sensitive index of AL, and lumbar and femoral BMD; a 10% increase in the FEV1/FVC ratio resulted in a significant increase of 0.025g/cm2 in the total hip (p=0.05), 0.027g/cm2 in the femoral neck (p=0.02), 0.028g/cm2 in the femoral trochanter (p=0.01), and 0.047g/cm2 in the lumbar (p=0.03) BMDs. Binary logistic analyses demonstrated more than a threefold higher risk of low BMD values for the lowest FEV1/FVC quartile in the lumbar (OR 4.62, 95% CI 1.48–14.40, p=0.008), total hip (OR 4.09, 95% CI 1.28–13.05, p=0.02 for the second quartile), and femoral trochanter regions (OR 3.90, 95% CI 1.25–12.20, p=0.02 for the third quartile). Conclusions: AL was associated with a higher risk of reduced BMD in healthy, fit elderly women. © 2016, Springer Science+Business Media New York.
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- 2016
7. The Impact of Smoking on Bone Metabolism, Bone Mineral Density and Vertebral Fractures in Postmenopausal Women.
- Author
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Trevisan C, Alessi A, Girotti G, Zanforlini BM, Bertocco A, Mazzochin M, Zoccarato F, Piovesan F, Dianin M, Giannini S, Manzato E, and Sergi G
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- Aged, Cigarette Smoking blood, Ex-Smokers, Female, Femur diagnostic imaging, Humans, Middle Aged, Non-Smokers, Osteoporosis blood, Osteoporosis diagnostic imaging, Osteoporosis epidemiology, Osteoporosis, Postmenopausal blood, Osteoporosis, Postmenopausal diagnostic imaging, Parathyroid Hormone blood, Postmenopause, Smokers, Tobacco Products, Vitamin D analogs & derivatives, Vitamin D blood, Bone Density, Cigarette Smoking epidemiology, Osteoporosis, Postmenopausal epidemiology, Osteoporotic Fractures epidemiology, Spinal Fractures epidemiology
- Abstract
Background: Smoking is recognized among the risk factors for osteoporosis, but only few studies have comprehensively explored its influence on bone metabolism and strength. We aimed to evaluate smoking effects on calcium-phosphate metabolism, bone mineral density (BMD) and fracture risk in postmenopausal women., Methods: Our sample included 1067 postmenopausal women who arrived to our osteoporosis outpatient clinic. Anamnestic data, smoking habits (categorized as never, former, and current; and by smoking intensity and duration), biochemical parameters, lumbar/femoral BMD, and presence of vertebral fractures were recorded. In a subsample of 357 women, the changes in BMD after a 2-yr follow-up period were also assessed., Results: Current smokers had shorter reproductive age, lower body mass index, and higher prevalence of heavy alcohol consumption than former/never smokers. They also had lower PTH values and weaker linear association between serum vitamin D and parathyroid hormone (current β = -0.11[SE = 0.004]; former β = -0.14[SE = 0.01]; never β = -0.20[SE = 0.003]; p < 0.01 for all). Baseline BMD did not reflect differences based on smoking habits, duration or intensity. However, after 2 years, only current smokers significantly worsened in femural BMD. After adjustment for confounders, the chance of having sustained vertebral fractures at the first evaluation increased by 74% (95% confidence interval:1.07-2.83) in current compared with never smokers, especially among heavy smokers., Conclusions: Smoking may negatively affect bone by inhibiting vitamin D-parathyroid hormone axis, reducing estrogen exposure, promoting risky health behaviors, and accelerating bone loss, especially at the femur. No significant differences were observed in these outcomes among former smokers, suggesting that quitting smoking has beneficial effects on bone health., (Copyright © 2019 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved.)
- Published
- 2020
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8. The impact of aging on pressure pain thresholds: are men less sensitive than women also in older age?
- Author
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Girotti G, Trevisan C, Fratta S, Toffanello ED, Inelmen EM, Manzato E, and Sergi G
- Abstract
Purpose: Men have generally demonstrated higher pressure pain thresholds (PPT) than women. However, the possible impact of aging on the gender differences in pain perception has not been fully evaluated. In this study, we aimed to investigate the gender differences in PPT over the life course, in young, middle-aged and older adults., Methods: This cross-sectional study involved 355 pain-free healthy individuals aged 19-95 years, divided into < 45, 45-64 and ≥ 65 years age groups. PPT were measured using Fisher's algometer. Data on anthropometry, formal education and occupation were collected for each participant, and a multidimensional geriatric assessment was performed in older individuals., Results: Lower PPT values were observed in old vs young adults (21.8 ± 8.7 N/cm
2 vs 59.5 ± 31.6, p < 0.0001) and in women vs men (16.3 ± 6.1 vs 42.8 ± 19.6 N/cm2 , p = 0.0003). A significant interaction emerged between age and sex in influencing PPT (pinteraction = 0.03). Although women had lower mean PPT values than men in all age groups, such gender difference diminished with aging, from 42.8 ± 19.6 vs 59.5 ± 31.6 N/cm2 (p = 0.001) to 16.3 ± 6.1 vs 21.8 ± 8.7 vs N/cm2 (p = 0.003) in younger and older women vs men, respectively., Conclusions: Female gender and older age are associated with lower PPT, but such gender difference seems to decrease with aging., (© 2019. European Geriatric Medicine Society.)- Published
- 2019
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