Author: "Gilbertson NM" / Publication Year Range: Last 10 years - Searchworks@Jio Institute Digital Library Search Results

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26 results on '"Gilbertson NM"'

1. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Author: Brauer, M, Roth, GA, Aravkin, AY, Zheng, P, Abate, KH, Abate, YH, Abbafati, C, Abbasgholizadeh, R, Abbasi, MA, Abbasian, M, Abbasifard, M, Abbasi-Kangevari, M, Abd ElHafeez, S, Abd-Elsalam, S, Abdi, P, Abdollahi, M, Abdoun, M, Abdulah, DM, Abdullahi, A, Abebe, M, Abedi, A, Abegaz, TM, Abeldaño Zuñiga, RA, Abiodun, O, Abiso, TL, Aboagye, RG, Abolhassani, H, Abouzid, M, Aboye, GB, Abreu, LG, Abualruz, H, Abubakar, B, Abu-Gharbieh, E, Abukhadijah, HJJ, Aburuz, S, Abu-Zaid, A, Adane, MM, Addo, IY, Addolorato, G, Adedoyin, RA, Adekanmbi, V, Aden, B, Adetunji, JB, Adeyeoluwa, TE, Adha, R, Adibi, A, Adnani, QES, Adzigbli, LA, Afolabi, AA, Afolabi, RF, Afshin, A, Afyouni, S, Afzal, MS, Afzal, S, Agampodi, SB, Agbozo, F, Aghamiri, S, Agodi, A, Agrawal, A, Agyemang-Duah, W, Ahinkorah, BO, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, N, Ahmad, S, Ahmad, T, Ahmed, A, Ahmed, LA, Ahmed, MB, Ahmed, S, Ahmed, SA, Ajami, M, Akalu, GT, Akara, EM, Akbarialiabad, H, Akhlaghi, S, Akinosoglou, K, Akinyemiju, T, Akkaif, MA, Akkala, S, Akombi-Inyang, B, Al Awaidy, S, Al Hasan, SM, Alahdab, F, AL-Ahdal, TMA, Alalalmeh, SO, Alalwan, TA, Al-Aly, Z, Alam, K, Alam, N, Alanezi, FM, Alanzi, TM, Albakri, A, AlBataineh, MT, Aldhaleei, WA, Aldridge, RW, Alemayohu, MA, Alemu, YM, Al-Fatly, B, Al-Gheethi, AAS, Al-Habbal, K, Alhabib, KF, Alhassan, RK, Ali, A, Ali, BA, Ali, I, Ali, L, Ali, MU, Ali, R, Ali, SSS, Ali, W, Alicandro, G, Alif, SM, Aljunid, SM, Alla, F, Al-Marwani, S, Al-Mekhlafi, HM, Almustanyir, S, Alomari, MA, Alonso, J, Alqahtani, JS, Alqutaibi, AY, Al-Raddadi, RM, Alrawashdeh, A, Al-Rifai, RH, Alrousan, SM, Al-Sabah, SK, Alshahrani, NZ, Altaany, Z, Altaf, A, Al-Tawfiq, JA, Altirkawi, KA, Aluh, DO, Alvis-Guzman, N, Alvis-Zakzuk, NJ, Alwafi, H, Al-Wardat, MS, Al-Worafi, YM, Aly, H, Aly, S, Alzoubi, KH, Al-Zyoud, W, Amaechi, UA, Aman Mohammadi, M, Amani, R, Amiri, S, Amirzade-Iranaq, MH, Ammirati, E, Amu, H, Amugsi, DA, Amusa, GA, Ancuceanu, R, Anderlini, D, Anderson, JA, Andrade, PP, Andrei, CL, Andrei, T, Anenberg, SC, Angappan, D, Angus, C, Anil, A, Anil, S, Anjum, A, Anoushiravani, A, Antonazzo, IC, Antony, CM, Antriyandarti, E, Anuoluwa, BS, Anvari, D, Anvari, S, Anwar, S, Anwar, SL, Anwer, R, Anyabolo, EE, Anyasodor, AE, Apostol, GLC, Arabloo, J, Arabzadeh Bahri, R, Arafat, M, Areda, D, Aregawi, BB, Aremu, A, Armocida, B, Arndt, MB, Ärnlöv, J, Arooj, M, Artamonov, AA, Artanti, KD, Aruleba, IT, Arumugam, A, Asbeutah, AM, Asgary, S, Asgedom, AA, Ashbaugh, C, Ashemo, MY, Ashraf, T, Askarinejad, A, Assmus, M, Astell-Burt, T, Athar, M, Athari, SS, Atorkey, P, Atreya, A, Aujayeb, A, Ausloos, M, Avila-Burgos, L, Awoke, AA, Ayala Quintanilla, BP, Ayatollahi, H, Ayestas Portugal, C, Ayuso-Mateos, JL, Azadnajafabad, S, Azevedo, RMS, Azhar, GS, Azizi, H, Azzam, AY, Backhaus, IL, Badar, M, Badiye, AD, Bagga, A, Baghdadi, S, Bagheri, N, Bagherieh, S, Bahrami Taghanaki, P, Bai, R, Baig, AA, Baker, JL, Bakkannavar, SM, Balasubramanian, M, Baltatu, OC, Bam, K, Bandyopadhyay, S, Banik, B, Banik, PC, Banke-Thomas, A, Bansal, H, Barchitta, M, Bardhan, M, Bardideh, E, Barker-Collo, SL, Bärnighausen, TW, Barone-Adesi, F, Barqawi, HJ, Barrero, LH, Barrow, A, Barteit, S, Basharat, Z, Basiru, A, Basso, JD, Bastan, M-M, Basu, S, Batchu, S, Batra, K, Batra, R, Baune, BT, Bayati, M, Bayileyegn, NS, Beaney, T, Behnoush, AH, Beiranvand, M, Béjot, Y, Bekele, A, Belgaumi, UI, Bell, AW, Bell, ML, Bello, MB, Bello, OO, Belo, L, Beloukas, A, Bendak, S, Bennett, DA, Bennitt, FB, Bensenor, IM, Benzian, H, Beran, A, Berezvai, Z, Bernabe, E, Bernstein, RS, Bettencourt, PJG, Bhagavathula, AS, Bhala, N, Bhandari, D, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Bhat, AN, Bhat, V, Bhatti, GK, Bhatti, JS, Bhatti, MS, Bhatti, R, Bhuiyan, MA, Bhutta, ZA, Bikbov, B, Bishai, JD, Bisignano, C, Biswas, A, Biswas, B, Biswas, RK, Bjørge, T, Boachie, MK, Boakye, H, Bockarie, MJ, Bodolica, V, Bodunrin, AO, Bogale, EK, Bolla, SR, Boloor, A, Bonakdar Hashemi, M, Boppana, SH, Bora Basara, B, Borhany, H, Botero Carvajal, A, Bouaoud, S, Boufous, S, Bourne, R, Boxe, C, Braithwaite, D, Brant, LC, Brar, A, Breitborde, NJK, Breitner, S, Brenner, H, Briko, AN, Britton, G, Brown, CS, Browne, AJ, Brunoni, AR, Bryazka, D, Bulamu, NB, Bulto, LN, Buonsenso, D, Burkart, K, Burns, RA, Busse, R, Bustanji, Y, Butt, NS, Butt, ZA, Caetano dos Santos, FL, Cagney, J, Cahuana-Hurtado, L, Calina, D, Cámera, LA, Campos, LA, Campos-Nonato, IR, Cao, C, Cao, F, Cao, Y, Capodici, A, Cárdenas, R, Carr, S, Carreras, G, Carrero, JJ, Carugno, A, Carvalho, F, Carvalho, M, Castaldelli-Maia, JM, Castañeda-Orjuela, CA, Castelpietra, G, Catalá-López, F, Catapano, AL, Cattaruzza, MS, Caye, A, Cederroth, CR, Cegolon, L, Cenderadewi, M, Cercy, KM, Cerin, E, Chadwick, J, Chakraborty, C, Chakraborty, PA, Chakraborty, S, Chan, JSK, Chan, RNC, Chandan, JS, Chandika, RM, Chaturvedi, P, Chen, A-T, Chen, CS, Chen, H, Chen, MX, Chen, M, Chen, S, Cheng, C-Y, Cheng, ETW, Cherbuin, N, Chi, G, Chichagi, F, Chimed-Ochir, O, Chimoriya, R, Ching, PR, Chirinos-Caceres, JL, Chitheer, A, Cho, WCS, Chong, B, Chopra, H, Chowdhury, R, Christopher, DJ, Chu, D-T, Chukwu, IS, Chung, E, Chung, S-C, Chutiyami, M, Cioffi, I, Cogen, RM, Cohen, AJ, Columbus, A, Conde, J, Corlateanu, A, Cortese, S, Cortesi, PA, Costa, VM, Costanzo, S, Criqui, MH, Cruz, JA, Cruz-Martins, N, Culbreth, GT, da Silva, AG, Dadras, O, Dai, X, Dai, Z, Daikwo, PU, Dalli, LL, Damiani, G, D'Amico, E, D'Anna, L, Darwesh, AM, Das, JK, Das, S, Dash, NR, Dashti, M, Dávila-Cervantes, CA, Davis Weaver, N, Davitoiu, DV, De la Hoz, FP, de la Torre-Luque, A, De Leo, D, Debopadhaya, S, Degenhardt, L, Del Bo', C, Delgado-Enciso, I, Delgado-Saborit, JM, Demoze, CK, Denova-Gutiérrez, E, Dervenis, N, Dervišević, E, Desai, HD, Desai, R, Devanbu, VGC, Dewan, SMR, Dhali, A, Dhama, K, Dhane, AS, Dhimal, ML, Dhimal, M, Dhingra, S, Dhulipala, VR, Dhungana, RR, Dias da Silva, D, Diaz, D, Diaz, LA, Diaz, MJ, Dima, A, Ding, DD, Dinu, M, Djalalinia, S, Do, TC, Do, THP, do Prado, CB, Dodangeh, M, Dohare, S, Dokova, KG, Dong, W, Dongarwar, D, D'Oria, M, Dorostkar, F, Dorsey, ER, Doshi, R, Doshmangir, L, Dowou, RK, Driscoll, TR, Dsouza, AC, Dsouza, HL, Dumith, SC, Duncan, BB, Duraes, AR, Duraisamy, S, Dushpanova, A, Dzianach, PA, Dziedzic, AM, Ebrahimi, A, Echieh, CP, Ed-Dra, A, Edinur, HA, Edvardsson, D, Edvardsson, K, Efendi, F, Eftekharimehrabad, A, Eini, E, Ekholuenetale, M, Ekundayo, TC, El Arab, RA, El Sayed Zaki, M, El-Dahiyat, F, Elemam, NM, Elgar, FJ, ElGohary, GMT, Elhabashy, HR, Elhadi, M, Elmehrath, AO, Elmeligy, OAA, Elshaer, M, Elsohaby, I, Emeto, TI, Esfandiari, N, Eshrati, B, Eslami, M, Esmaeili, SV, Estep, K, Etaee, F, Fabin, N, Fagbamigbe, AF, Fagbule, OF, Fahimi, S, Falzone, L, Fareed, M, Farinha, CSES, Faris, MEM, Faris, PS, Faro, A, Fasina, FO, Fatehizadeh, A, Fauk, NK, Fazylov, T, Feigin, VL, Feng, X, Fereshtehnejad, S-M, Feroze, AH, Ferrara, P, Ferrari, AJ, Ferreira, N, Fetensa, G, Feyisa, BR, Filip, I, Fischer, F, Fitriana, I, Flavel, J, Flohr, C, Flood, D, Flor, LS, Foigt, NA, Folayan, MO, Force, LM, Fortuna, D, Foschi, M, Franklin, RC, Freitas, A, Friedman, SD, Fux, B, G, S, Gaal, PA, Gaihre, S, Gajdács, M, Galali, Y, Gallus, S, Gandhi, AP, Ganesan, B, Ganiyani, MA, Garcia, V, Gardner, WM, Garg, RK, Gautam, RK, Gebi, TG, Gebregergis, MW, Gebrehiwot, M, Gebremariam, TBB, Gebremeskel, TG, Gerema, U, Getacher, L, Getahun, GKA, Getie, M, Ghadirian, F, Ghafarian, S, Ghaffari Jolfayi, A, Ghailan, KY, Ghajar, A, Ghasemi, M, Ghasempour Dabaghi, G, Ghasemzadeh, A, Ghassemi, F, Ghazy, RM, Gholami, A, Gholamrezanezhad, A, Gholizadeh, N, Ghorbani, M, Gil, AU, Gil, GF, Gilbertson, NM, Gill, PS, Gill, TK, Gindaba, EZ, Girmay, A, Glasbey, JC, Gnedovskaya, EV, Göbölös, L, Godinho, MA, Goel, A, Golechha, M, Goleij, P, Golinelli, D, Gomes, NGM, Gopalani, SV, Gorini, G, Goudarzi, H, Goulart, AC, Gouravani, M, Goyal, A, Graham, SM, Grivna, M, Grosso, G, Guan, S-Y, Guarducci, G, Gubari, MIM, Guha, A, Guicciardi, S, Gulati, S, Gulisashvili, D, Gunawardane, DA, Guo, C, Gupta, AK, Gupta, B, Gupta, M, Gupta, R, Gupta, RD, Gupta, S, Gupta, VB, Gupta, VK, Habibzadeh, F, Habibzadeh, P, Hadaro, TS, Hadian, Z, Haep, N, Haghi-Aminjan, H, Haghmorad, D, Hagins, H, Haile, D, Hailu, A, Hajj Ali, A, Halboub, ES, Halimi, A, Hall, BJ, Haller, S, Halwani, R, Hamadeh, RR, Hamdy, NM, Hameed, S, Hamidi, S, Hammoud, A, Hanif, A, Hanifi, N, Haq, ZA, Haque, MR, Harapan, H, Hargono, A, Haro, JM, Hasaballah, AI, Hasan, I, Hasan, MJ, Hasan, SMM, Hasani, H, Hasanian, M, Hashmeh, N, Hasnain, MS, Hassan, A, Hassan, I, Hassan Zadeh Tabatabaei, MS, Hassani, S, Hassanipour, S, Hassankhani, H, Haubold, J, Havmoeller, RJ, Hay, SI, Hebert, JJ, Hegazi, OE, Hegena, TY, Heidari, G, Heidari, M, Helfer, B, Hemmati, M, Henson, CA, Herbert, ME, Herteliu, C, Heuer, A, Hezam, K, Hinneh, TK, Hiraike, Y, Hoan, NQ, Holla, R, Hon, J, Hoque, ME, Horita, N, Hossain, S, Hosseini, SE, Hosseinzadeh, H, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Hoven, H, Hsairi, M, Hsu, JM, Hu, C, Huang, J, Huda, MN, Hulland, EN, Hultström, M, Hushmandi, K, Hussain, J, Hussein, NR, Huynh, CK, Huynh, H-H, Ibitoye, SE, Idowu, OO, Ihler, AL, Ikeda, N, Ikuta, KS, Ilesanmi, OS, Ilic, IM, Ilic, MD, Imam, MT, Immurana, M, Inbaraj, LR, Irham, LM, Isa, MA, Islam, MR, Ismail, F, Ismail, NE, Iso, H, Isola, G, Iwagami, M, Iwu, CCD, Iwu-Jaja, CJ, J, V, Jaafari, J, Jacob, L, Jacobsen, KH, Jadidi-Niaragh, F, Jahankhani, K, Jahanmehr, N, Jahrami, H, Jain, A, Jain, N, Jairoun, AA, Jaiswal, A, Jakovljevic, M, Jalilzadeh Yengejeh, R, Jamora, RDG, Jatau, AI, Javadov, S, Javaheri, T, Jayaram, S, Jeganathan, J, Jeswani, BM, Jiang, H, Johnson, CO, Jokar, M, Jomehzadeh, N, Jonas, JB, Joo, T, Joseph, A, Joseph, N, Joshi, V, Joshua, CE, Jozwiak, JJ, Jürisson, M, Kaambwa, B, Kabir, A, Kabir, Z, Kadashetti, V, Kahn, EM, Kalani, R, Kaliyadan, F, Kalra, S, Kamath, R, Kanagasabai, T, Kanchan, T, Kandel, H, Kanmiki, EW, Kanmodi, KK, Kansal, SK, Kapner, DJ, Kapoor, N, Karagiannidis, E, Karajizadeh, M, Karakasis, P, Karanth, SD, Karaye, IM, Karch, A, Karim, A, Karimi, H, Karmakar, S, Kashoo, FZ, Kasraei, H, Kassahun, WD, Kassebaum, NJ, Kassel, MB, Katikireddi, SV, Kauppila, JH, Kawakami, N, Kaydi, N, Kayode, GA, Kazemi, F, Keiyoro, PN, Kemmer, L, Kempen, JH, Kerr, JA, Kesse-Guyot, E, Khader, YS, Khafaie, MA, Khajuria, H, Khalaji, A, Khalil, M, Khalilian, A, Khamesipour, F, Khan, A, Khan, MN, Khan, M, Khan, MJ, Khan, MAB, Khanmohammadi, S, Khatab, K, Khatatbeh, H, Khatatbeh, MM, Khatib, MN, Khavandegar, A, Khayat Kashani, HR, Khidri, FF, Khodadoust, E, Khormali, M, Khorrami, Z, Khosla, AA, Khosrowjerdi, M, Khreis, H, Khusun, H, Kifle, ZD, Kim, K, Kim, MS, Kim, YJ, Kimokoti, RW, Kisa, A, Kisa, S, Knibbs, LD, Knudsen, AKS, Koh, DSQ, Kolahi, A-A, Kompani, F, Kong, J, Koren, G, Korja, M, Korshunov, VA, Korzh, O, Kosen, S, Kothari, N, Koul, PA, Koulmane Laxminarayana, SL, Krishan, K, Krishnamoorthy, V, Krishnamoorthy, Y, Krishnan, B, Krohn, KJ, Kuate Defo, B, Kucuk Bicer, B, Kuddus, MA, Kuddus, M, Kugbey, N, Kuitunen, I, Kulimbet, M, Kulkarni, V, Kumar, A, Kumar, N, Kumar, V, Kundu, S, Kurmi, OP, Kusnali, A, Kusuma, D, Kutluk, T, La Vecchia, C, Ladan, MA, Laflamme, L, Lahariya, C, Lai, DTC, Lal, DK, Lallukka, T, Lám, J, Lan, Q, Lan, T, Landires, I, Lanfranchi, F, Langguth, B, Lansingh, VC, Laplante-Lévesque, A, Larijani, B, Larsson, AO, Lasrado, S, Lauriola, P, Le, H-H, Le, LKD, Le, NHH, Le, TTT, Leasher, JL, Ledda, C, Lee, M, Lee, PH, Lee, SW, Lee, SWH, Lee, YH, LeGrand, KE, Leigh, J, Leong, E, Lerango, TL, Lescinsky, H, Leung, J, Li, M-C, Li, W-Z, Li, W, Li, Y, Li, Z, Ligade, VS, Lim, L-L, Lim, SS, Lin, R-T, Lin, S, Liu, C, Liu, G, Liu, J, Liu, RT, Liu, S, Liu, W, Liu, X, Livingstone, KM, Llanaj, E, Lohiya, A, López-Bueno, R, Lopukhov, PD, Lorkowski, S, Lotufo, PA, Lozano, R, Lubinda, J, Lucchetti, G, Luo, L, lv, H, M Amin, HI, Ma, ZF, Maass, KL, Mabrok, M, Machairas, N, Machoy, M, Mafhoumi, A, Magdy Abd El Razek, M, Maghazachi, AA, Mahadeshwara Prasad, DR, Maharaj, SB, Mahmoud, MA, Mahmoudi, E, Majeed, A, Makram, OM, Makris, KC, Malasala, S, Maled, V, Malhotra, K, Malik, AA, Malik, I, Malinga, LA, Malta, DC, Mamun, AA, Manda, AL, Manla, Y, Mansour, A, Mansouri, B, Mansouri, P, Mansourian, M, Mansournia, MA, Mantovani, LG, Manu, E, Marateb, HR, Maravilla, JC, Marsh, E, Martinez, G, Martinez-Piedra, R, Martini, S, Martins-Melo, FR, Martorell, M, Marx, W, Maryam, S, Mathangasinghe, Y, Mathioudakis, AG, Matozinhos, FP, Mattumpuram, J, Maugeri, A, Maulik, PK, Mayeli, M, Mazidi, M, Mazzotti, A, McGrath, JJ, McKee, M, McKowen, ALW, McLaughlin, SA, McPhail, MA, McPhail, SM, Mechili, EA, Mehmood, A, Mehmood, K, Mehrabani-Zeinabad, K, Mehrabi Nasab, E, Meier, T, Mejia-Rodriguez, F, Mekene Meto, T, Mekonnen, BD, Menezes, RG, Mengist, B, Mensah, GA, Mensah, LG, Mentis, A-FA, Meo, SA, Meretoja, A, Meretoja, TJ, Mersha, AM, Mesfin, BA, Mestrovic, T, Mettananda, KCD, Mettananda, S, Miazgowski, T, Micha, G, Michalek, IM, Micheletti Gomide Nogueira de Sá, AC, Miller, TR, Mirarefin, M, Mirghafourvand, M, Mirica, A, Mirijello, A, Mirrakhimov, EM, Mirshahi, A, Mirzaei, M, Mishra, AK, Mishra, V, Mitchell, PB, Mithra, P, Mittal, C, Moazen, B, Moberg, ME, Mocciaro, G, Mohamadkhani, A, Mohamed, AZ, Mohamed, AI, Mohamed, J, Mohamed, MFH, Mohamed, NS, Mohammadi, E, Mohammadi, S, Mohammadian-Hafshejani, A, Mohammadifard, N, Mohammed, H, Mohammed, M, Mohammed, S, Mokdad, AH, Monasta, L, Mondello, S, Moni, MA, Moodi Ghalibaf, A, Moore, CE, Moradi, M, Moradi, Y, Moraga, P, Morawska, L, Moreira, RS, Morovatdar, N, Morrison, SD, Morze, J, Mosaddeghi Heris, R, Mossialos, E, Motappa, R, Mougin, V, Mousavi, P, Msherghi, A, Mubarik, S, Muccioli, L, Mueller, UO, Mulita, F, Mullany, EC, Munjal, K, Murillo-Zamora, E, Murlimanju, BV, Musina, A-M, Mustafa, G, Muthu, S, Muthupandian, S, Muthusamy, R, Muzaffar, M, Myung, W, Nafei, A, Nagarajan, AJ, Nagaraju, SP, Nagel, G, Naghavi, M, Naghavi, P, Naik, GR, Naik, G, Nainu, F, Nair, TS, Najdaghi, S, Nakhostin Ansari, N, Nanavaty, DP, Nangia, V, Narasimha Swamy, S, Narimani Davani, D, Nascimento, BR, Nascimento, GG, Nashwan, AJ, Natto, ZS, Nauman, J, Navaratna, SNK, Naveed, M, Nayak, BP, Nayak, VC, Ndejjo, R, Nduaguba, SO, Negash, H, Negoi, I, Negoi, RI, Nejadghaderi, SA, Nejjari, C, Nematollahi, MH, Nepal, S, Neupane, S, Ng, M, Nguefack-Tsague, G, Ngunjiri, JW, Nguyen, DH, Nguyen, NNY, Nguyen, PT, Nguyen, VT, Nguyen Tran Minh, D, Niazi, RK, Nicholson, SI, Nie, J, Nikoobar, A, Nikpoor, AR, Ningrum, DNA, Nnaji, CA, Noman, EA, Nomura, S, Noroozi, N, Norrving, B, Noubiap, JJ, Nri-Ezedi, CA, Ntaios, G, Ntsekhe, M, Nunemo, MH, Nurrika, D, Nutor, JJ, Oancea, B, O'Connell, EM, Odetokun, IA, O'Donnell, MJ, Oduro, MS, Ogunfowokan, AA, Ogunkoya, A, Oh, I-H, Okati-Aliabad, H, Okeke, SR, Okekunle, AP, Okonji, OC, Olagunju, AT, Olasupo, OO, Olatubi, MI, Oliveira, AB, Oliveira, GMM, Olorukooba, AA, Olufadewa, II, Olusanya, BO, Olusanya, JO, Oluwafemi, YD, Omar, HA, Omar Bali, A, Omer, GL, Ong, KL, Ong, S, Onwujekwe, OE, Onyedibe, KI, Oppong, AF, Ordak, M, Orish, VN, Ornello, R, Orpana, HM, Ortiz, A, Ortiz-Prado, E, Osman, WMS, Ostroff, SM, Osuagwu, UL, Otoiu, A, Otstavnov, N, Otstavnov, SS, Ouyahia, A, Owolabi, MO, Oyeyemi, IT, Oyeyemi, OT, P A, MP, Pacheco-Barrios, K, Padron-Monedero, A, Padubidri, JR, Pal, PK, Palicz, T, Pan, F, Pan, H-F, Pana, A, Panda, SK, Panda-Jonas, S, Pandey, A, Pandi-Perumal, SR, Pangaribuan, HU, Pantazopoulos, I, Pantea Stoian, AM, Papadopoulou, P, Parent, MC, Parija, PP, Parikh, RR, Park, S, Parsons, N, Pashaei, A, Pasovic, M, Passera, R, Patil, S, Patoulias, D, Patthipati, VS, Paudel, U, Pawar, S, Pazoki Toroudi, H, Peden, AE, Pedersini, P, Peng, M, Pensato, U, Pepito, VCF, Peprah, EK, Peprah, P, Peres, MFP, Perianayagam, A, Perico, N, Perna, S, Pesudovs, K, Petcu, I-R, Petermann-Rocha, FE, Pham, HT, Philip, AK, Phillips, MR, Pickering, BV, Pierannunzio, D, Pigeolet, M, Pigott, DM, Piracha, ZZ, Piradov, MA, 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YF, Wiangkham, T, Wickramasinghe, ND, Wilkerson, C, Willeit, P, Wilson, S, Wong, YJ, Wongsin, U, Wozniak, S, Wu, C, Wu, D, Wu, F, Wu, Z, Xia, J, Xiao, H, Xu, S, Xu, X, Xu, YY, Yadav, MK, Yaghoubi, S, Yamagishi, K, Yang, L, Yano, Y, Yaribeygi, H, Yasufuku, Y, Ye, P, Yesodharan, R, Yesuf, SA, Yezli, S, Yi, S, Yiğit, A, Yigzaw, ZA, Yin, D, Yip, P, Yismaw, MB, Yon, DK, Yonemoto, N, You, Y, Younis, MZ, Yousefi, Z, Yu, C, Yu, Y, Zadey, S, Zadnik, V, Zakham, F, Zaki, N, Zakzuk, J, Zamagni, G, Zaman, SB, Zandieh, GGZ, Zanghì, A, Zar, HJ, Zare, I, Zarimeidani, F, Zastrozhin, MS, Zeng, Y, Zhai, C, Zhang, AL, Zhang, H, Zhang, L, Zhang, M, Zhang, Y, Zhang, Z, Zhang, Z-J, Zhao, H, Zhao, JT, Zhao, X-JG, Zhao, Y, Zhong, C, Zhou, J, Zhou, S, Zhu, B, Zhu, L, Zhu, Z, Ziaeian, B, Ziafati, M, Zielińska, M, Zimsen, SRM, Zoghi, G, Zoller, T, Zumla, A, Zyoud, SH, Murray, CJL, and Gakidou, E
Published: 2024

2. Block-pulse integrodifference equations.

Author: Gilbertson NM and Kot M
Subjects: Models, Theoretical, Population Growth
Abstract: We present a hybrid method for calculating the equilibrium population-distributions of integrodifference equations (IDEs) with strictly increasing growth, for populations that are confined to a finite habitat-patch. This method is based on approximating the growth function of the IDE with a piecewise-constant function, and we call the resulting model a block-pulse IDE. We explicitly write out analytic expressions for the iterates and equilibria of the block-pulse IDEs as sums of cumulative distribution functions. We characterize the dynamics of one-, two-, and three-step block-pulse IDEs, including formal stability analyses, and we explore the bifurcation structure of these models. These simple models display rich dynamics, with numerous fold bifurcations. We then use three-, five-, and ten-step block-pulse IDEs, with a numerical root finder, to approximate models with compensatory Beverton-Holt growth and depensatory, or Allee-effect, growth. Our method provides a good approximation for the equilibrium distributions for compensatory and depensatory growth and offers numerical and analytical advantages over the original growth models., (© 2023. The Author(s).)
Published: 2023
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3. The impact of the COVID-19 pandemic on perceptions of health, well-being, and college experience in Division III student-athletes.

Author: Gilbertson NM and Loomis PV
Abstract: Objective: Determine the impact of the COVID-19 pandemic on student-athletes. Participants: Participants (n = 238) were Division III student-athletes (18-24yrs) enrolled at a Pennsylvania State University campus during the Fall 2020 semester. Methods: Student-athletes were emailed a link of a 43-question survey which was deployed using Qualtrics®. The survey asked questions about collegiate experience, health, well-being, sport related training, and physical fitness before and during the pandemic. Results: Approximately 94% of student-athletes reported that COVID-19 worsened their college experience. About 52 and 59% of student-athletes believed that COVID-19 had a negative impact on their health and well-being, respectively. Nearly 79% of student-athletes reported that their sport-related training decreased during the pandemic. Over half of participants believed that their physical fitness, endurance, and strength decreased during the pandemic. Conclusion: The implications of the COVID-19 pandemic on Division III collegiate student-athletes include a worsened college experience as well as worsened health and well-being.
Published: 2022
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4. Impact of a short-term low calorie diet alone or with interval exercise on quality of life and oxidized phospholipids in obese females.

Author: Gilbertson NM, Eichner NZM, Gaitán JM, Pirtle JM, Kirby JL, Upchurch CM, Leitinger N, and Malin SK
Subjects: Adult, Diet, Reducing, Female, Humans, Hydroxyeicosatetraenoic Acids, Middle Aged, Obesity, Phospholipids, Caloric Restriction, Quality of Life
Abstract: The objective of this study was to test if a low-calorie diet plus interval exercise (LCD+INT) reduced oxidized and non-oxidized phospholipids in relation to improved weight-related quality of life (QoL) to a greater extent than an energy-deficit matched LCD in obese females. Subjects (age: 47.2 ± 2.6 years, body mass index: 37.5 ± 1.3 kg/m 2 ) were randomized to a 13-day LCD (n = 12; mixed meals of ∼1200 kcal/day) or LCD+INT (n = 13; 12 sessions of 60 min/day alternating 3 min at 50% and 90% peak heart rate plus an additional 350 kcal shake fed after exercise to match energy availability between groups). Weight-related QoL (Laval Questionnaire) as well as oxidized (POVPC, HOOA-PC, HPETE-PC, HETE-PC, PEIPC, KOOA-PC) and non-oxidized (PAPC and lysoPC) phospholipids were assessed pre- and post-intervention. Fitness (VO 2 peak), body composition (BodPod), and clinical bloods were also tested. LCD+INT significantly increased VO 2 peak (mL/kg/min, P = 0.03) compared to LCD despite similar fat loss, blood glucose, insulin sensitivity, and inflammatory responses. LCD+INT had significantly greater increases in QoL sexual life domain (P = 0.05) and tended to have a greater increase in the emotions domain (P = 0.09) and total score (P = 0.10) compared to LCD. There were no significant differences between treatments for changes in phospholipids despite LCD+INT increasing measured oxidized and non-oxidized phospholipids while LCD decreased POVPC, HOOA-PC, and PEIPC as well as non-oxidized PAPC and lysoPC. Interestingly, the rise in PEIPC correlated with elevated VO 2 peak (mL/kg/min r = 0.42, P = 0.05). Decreased caloric intake was, however, linked to a decrease in PAPC (r = 0.53, P = 0.01), lysoPC (r = 0.52, P = 0.02), POVPC (r = 0.43, P = 0.05), and HPETE-PC (r = 0.43, P = 0.05). The decrease in HETE-PC also correlated with increases in the QoL domains symptoms (r = -0.46, P = 0.04), hygiene/clothing (r = -0.53, P = 0.01), emotions (r = -0.53, P = 0.01), social interactions (r = -0.49, P = 0.02), and total score (r = -0.52, P = 0.02). In conclusion, although LCD and LCD+INT improved weight related QoL over 13 days in females with obesity, LCD+INT tended to improve sexual life, emotions as well as total QoL score more than LCD. These data suggest caloric restriction and fitness may act through different mechanisms to support QoL., (Copyright © 2022. Published by Elsevier Inc.)
Published: 2022
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5. Effect of presurgical aerobic exercise on cardiometabolic health 30 days after bariatric surgery.

Author: Gilbertson NM, Eichner NZM, Gaitán JM, Khurshid M, Rexrode EA, Kranz S, Hallowell PT, and Malin SK
Subjects: Adult, Bariatric Surgery adverse effects, Body Composition, Female, Humans, Insulin blood, Male, Middle Aged, Postoperative Complications epidemiology, Preoperative Period, Vascular Stiffness, Bariatric Surgery methods, Cardiorespiratory Fitness, Exercise Therapy methods, Oxygen Consumption, Postoperative Complications prevention & control
Abstract: We evaluated the effect of preoperative standard medical care (SC) vs. unsupervised aerobic exercise combined with SC (EX + SC) on cardiometabolic health and quality of life (QoL) 30 days after bariatric surgery. Bariatric patients (n = 14, age: 42.3 ± 2.5 years, body mass index: 45.1 ± 2.5 kg/m 2 ) were match-paired to presurgical SC (n = 7) or EX + SC (n = 7; walking 30 min/day, 5 day/week, 65-85% HR peak ) for 30 days. Body composition, peak cardiorespiratory fitness (VO 2 peak), QoL, inflammation (adiponectin, leptin, cytokeratin-18), and a 120 min mixed meal tolerance test was performed to assess aortic waveforms (augmentation index, AIx@75), insulin sensitivity, and glucose total area under the curve (tAUC) at the time of surgery (post-intervention) and 30 days post-surgery. EX + SC had significantly higher high molecular weight (HMW) adiponectin (p = 0.01) and ratio of HMW to total adiponectin (p = 0.04) than SC at 30 days post-surgery, although they significantly (p = 0.006; ES = 1.86) decreased total time spent in moderate to vigorous physical activity (MVPA). SC had a significantly greater increase in VO 2 peak (p = 0.02; ES = 1.54) and decrease in 120 min AIx@75 (p = 0.02; ES = 1.78) than EX + SC during the post-surgical period. The increase in MVPA was associated with a reduction in cytokeratin-18 (r = -0.67, p = 0.02). Increased VO 2 peak was associated with increased activity/mobility QoL domain (r = 0.52, p = 0.05) and decreased 120 min AIx@75 (r = -0.61, p = 0.03) from surgery to post-surgery. Preoperative EX + SC did not maintain more favorable cardiometabolic health 30 days post-operation in this pilot study. However, changes in MVPA appear important for QoL and should be considered in future work., (© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
Published: 2021
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6. A Low-Calorie Diet with or without Exercise Reduces Postprandial Aortic Waveform in Females with Obesity.

Author: Heiston EM, Gilbertson NM, Eichner NZM, and Malin SK
Subjects: Aorta physiology, Body Composition, Female, Glucose Tolerance Test, Heart Rate physiology, Humans, Inflammation blood, Insulin Resistance, Menopause, Middle Aged, Obesity blood, Obesity diet therapy, Physical Fitness, Pulse Wave Analysis, Time Factors, Weight Loss physiology, Caloric Restriction, Exercise physiology, Fasting physiology, Obesity physiopathology, Postprandial Period physiology, Vascular Stiffness physiology
Abstract: Purpose: Arterial stiffness is considered a predictor of cardiovascular disease. Females have higher values of arterial stiffness than males, suggesting a greater risk of heart-related complications. Although a low-calorie diet (LCD) reduces fasting arterial stiffness, in part through weight loss, it is unknown if interval exercise (INT) adds to the benefit of LCD on fasting and postprandial arterial stiffness in females with obesity., Methods: Twenty-five females (47 ± 2.6 yr, 37.6 ± 1.3 kg·m-2) were randomized to 13 d of LCD (n = 12; mixed meals of ~1200 kcal·d-1) or LCD + INT (n = 13; 60 min·d-1 of supervised 3-min intervals at 90% HRpeak and 50% HRpeak). Arterial stiffness (augmentation index [AIx] and carotid-femoral pulse wave velocity [cfPWV]) and blood biochemistries were measured during a 75-g oral glucose tolerance test before and after the intervention to determine fasting and postprandial arterial stiffness as well as insulin sensitivity (simple index of insulin sensitivity [SIIS]) and inflammation (C-reactive protein, interleukin 8, and tumor necrosis factor alpha)., Results: Although LCD + INT increased V˙O2peak and HDL compared with LCD (P = 0.04 and P < 0.01, respectively), both interventions decreased body fat, LDL, total cholesterol, and triglycerides (all P < 0.01) and increased SIIS (P = 0.03). Despite no effect on fasting AIx (P = 0.27), LCD and LCD + INT decreased AIx60min (-7.4% ± 4.3% vs -7.0% ± 5.0%, P = 0.04) and tAUC120min (-663 ± 263 vs -457 ± 406, P = 0.03). There were no changes in fasting cfPWV (P = 0.91) or cfPWV120min (P = 0.62). Increased SIIS and decreased interleukin 8 were associated with reduced fasting AIx (r = -0.44, P = 0.03, and r = 0.40, P = 0.055), whereas decreased C-reactive protein correlated with reduced postprandial AIx60min (r = 0.43, P = 0.04)., Conclusion: Independent of exercise, 13 d of LCD reduces postprandial AIx in females with obesity. Insulin sensitivity and inflammation correlated with improved arterial stiffness, suggesting unique mechanisms regulate fasted versus postprandial arterial stiffness., (Copyright © 2020 by the American College of Sports Medicine.)
Published: 2021
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7. Improving gait efficiency to increase movement and physical activity - The impact of abnormal gait patterns and strategies to correct.

Author: Slater L, Gilbertson NM, and Hyngstrom AS
Subjects: Humans, Exercise physiology, Exercise Therapy methods, Gait physiology, Stroke physiopathology, Stroke Rehabilitation methods, Walking physiology
Abstract: Increasing daily steps is important to maintain health and prevent both initial and subsequent cardiovascular (CV) disease (CVD) events. Even 5000 steps have been associated with reduced risk of CVD, however many adults and those with CVD walk fewer than 5000 daily steps. Reduced gait speed is a precursor to decreased physical engagement and is associated with biomarker changes linked to higher risk of CVD. Gait speed is decreased in those with CVD, which may be from changes in biomechanics including reduced step length and increased gait variability. Changes in gait and daily steps are often most discernable post-stroke, which may be from limitations of the CV system in meeting the metabolic demands of walking and the nervous system in exciting motoneuron pools to generate muscle force. This leads to gait asymmetries and decreased speed. Information regarding the effects of rehabilitation interventions (e.g., physical therapy) to increase physical activity (PA) in stroke survivors is limited. Current interventions include high intensity gait training and ischemic conditioning to improve walking speed and fatigability. Given the potential benefits of increased PA and daily steps following stroke, there is a need for more research investigating optimal dosage of daily steps and interventions to improve PA., Competing Interests: Declaration of Competing Interest None., (Copyright © 2020 Elsevier Inc. All rights reserved.)
Published: 2021
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8. Pre-operative aerobic exercise on metabolic health and surgical outcomes in patients receiving bariatric surgery: A pilot trial.

Author: Gilbertson NM, Gaitán JM, Osinski V, Rexrode EA, Garmey JC, Mehaffey JH, Hassinger TE, Kranz S, McNamara CA, Weltman A, Hallowell PT, and Malin SK
Subjects: Adipokines metabolism, Adipose Tissue metabolism, Adult, Body Composition, Female, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Morbid metabolism, Physical Fitness, Pilot Projects, Preoperative Care methods, Preoperative Period, Treatment Outcome, Bariatric Surgery, Exercise, Exercise Therapy methods, Obesity, Morbid surgery, Obesity, Morbid therapy
Abstract: Objective: Examine if adding aerobic exercise to standard medical care (EX+SC) prior to bariatric surgery improves metabolic health in relation to surgical outcomes., Methods: Fourteen bariatric patients (age: 42.3±2.5y, BMI: 45.1±2.5 kg/m2) met inclusion criteria and were match-paired to pre-operative SC (n = 7) or EX+SC (n = 7; walking 30min/d, 5d/wk, 65-85% HRpeak) for 30d. A 120min mixed meal tolerance test was performed pre- and post-intervention (~2d prior to surgery) to assess insulin sensitivity (Matsuda Index) and metabolic flexibility (indirect calorimetry). Aerobic fitness (VO2peak), body composition (BodPod), and adipokines (adiponectin, leptin) were also measured. Omental adipose tissue was collected during surgery to quantify gene expression of adiponectin and leptin, and operating time and length of hospital stay were recorded. ANOVA and Cohen's d effect size (ES) was used to test group differences., Results: SC tended to increase percent body fat (P = 0.06) after the intervention compared to EX+SC. Although SC and EX+SC tended to raise insulin sensitivity (P = 0.11), EX+SC enhanced metabolic flexibility (P = 0.01, ES = 1.55), reduced total adiponectin (P = 0.01, ES = 1.54) with no change in HMW adiponectin and decreased the length of hospital stay (P = 0.05) compared to SC. Albeit not statistically significant, EX+SC increased VO2peak 2.9% compared to a 5.9% decrease with SC (P = 0.24, ES = 0.91). This increased fitness correlated to shorter operating time (r = -0.57, P = 0.03) and length of stay (r = -0.58, P = 0.03). Less omental total adiponectin (r = 0.52, P = 0.09) and leptin (r = 0.58, P = 0.05) expression correlated with shorter operating time, and low leptin expression was linked to shorter length of stay (r = 0.70, P = 0.01), and low leptin expression was linked to shorter length of stay (r = 0.70, P = 0.01)., Conclusion: Adding pre-operative aerobic exercise to standard care may improve surgical outcomes through a fitness and adipose tissue derived mechanism., Competing Interests: The authors have declared that no competing interests exist.
Published: 2020
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9. Short-term interval exercise suppresses acylated ghrelin and hunger during caloric restriction in women with obesity.

Author: Malin SK, Heiston EM, Gilbertson NM, and Eichner NZM
Subjects: Appetite, Energy Intake, Exercise, Female, Humans, Hunger, Obesity therapy, Peptide YY, Caloric Restriction, Ghrelin
Abstract: Caloric restriction is suggested to increase hunger, in part, through complex interactions of hormones and behavior that contribute to challenges in long-term weight loss. Although intense exercise may attenuate appetite, no data exist testing the effects of interval exercise (INT) during a low-calorie diet (LCD) on appetite regulation. We hypothesized that LCD+INT would favorably influence satiety when compared with an energy-deficit matched LCD in women with obesity. Twenty-six women with obesity (47.3±2.4 yrs; 37.3 ± 1.2 kg/m 2 ) were randomized to either LCD (n = 13; mixed meals of ~1200 kcal/d) or LCD+INT (n = 13; 60 min/d of supervised interval exercise at 90% HRpeak for 3 min and 50% HRpeak for 3 min) for 2 weeks. An additional 350kcal (shake) was provided to LCD+INT individuals post-exercise to equate energy availability between groups. Total PYY, acylated ghrelin and des-ghrelin were measured at 0, 30 and 60 min of a 75g OGTT before and after the intervention. Visual analog scales were also administered at 0 and 120 min of the OGTT to assess appetite perception. Food logs were recorded prior to and during the intervention to ensure caloric intake compliance. Compared with pre-intervention conditions, both interventions decreased food intake (P = 0.001) and body fat (P < 0.01). There was no effect on fasting PYY, but both LCD and LCD+INT increased post-prandial PYY iAUC (P < 0.001) relative to pre-intervention. LCD+INT maintained fasting acylated ghrelin (P = 0.06) and suppressed post-prandial acylated ghrelin iAUC (P = 0.04) compared to LCD. Neither intervention impacted circulating des- ghrelin before or following the OGTT. Interestingly, LCD+INT attenuated fasting hunger and maintained fullness compared with LCD (P = 0.05 and P = 0.06, respectively). Taken together, interval exercise favors acylated ghrelin suppression and perception of hunger during a LCD in women with obesity., Competing Interests: Declaration of Competing Interest None to disclose., (Copyright © 2020 Elsevier Inc. All rights reserved.)
Published: 2020
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10. Impact of Pre-operative Aerobic Exercise on Cardiometabolic Health and Quality of Life in Patients Undergoing Bariatric Surgery.

Author: Gilbertson NM, Eichner NZM, Khurshid M, Rexrode EA, Kranz S, Weltman A, Hallowell PT, and Malin SK
Abstract: Objective: Examine the effect of aerobic exercise (EX) combined with standard medical care (SC) (EX + SC) compared to SC alone on cardiometabolic health and quality of life in relation to surgical outcomes., Methods: Patients receiving bariatric surgery were match-paired to 30 days of pre-operative SC ( n = 7, 1 male, 39.0 ± 5.3 years, body mass index 46.4 ± 3.0 kg/m 2 ; low calorie diet) or EX + SC ( n = 7, 0 males, 45.6 ± 4.8 years, body mass index 43.9 ± 4.2 kg/m 2 ; walking 30 min/day, 5 days/week, 65-85% HR peak ). Body mass, waist circumference, cardiorespiratory fitness (VO 2 peak), high sensitivity C-reactive protein (hs-CRP), cytokeratin 18 (CK18), weight related quality of life (QoL), and a 120 min mixed meal tolerance test (MMTT) was performed to assess arterial stiffness via augmentation index normalized to a heart rate of 75 beats per minute (AIx@75), whole-body insulin sensitivity, and glucose total area under the curve (tAUC) pre- and post-intervention (∼2 days prior to surgery). Length of hospital stay (admission to discharge) was recorded., Results: EX + SC had a greater effect for decreased intake of total calories ( P = 0.14; ES = 0.86) compared to SC, but no change in body weight or waist circumference was observed in either group. EX + SC had a greater effect for increased VO 2 peak ( P = 0.24; ES = 0.91) and decreased hs-CRP ( P = 0.31; ES = 0.69) compared to SC. EX + SC reduced circulating CK18 ( P = 0.05; ES = 3.05) and improved QoL ( P = 0.02) compared to SC. Although EX + SC had no statistical effect on arterial stiffness compared to SC, we observed a modest effect size for AIx@75 tAUC ( P = 0.36; ES = 0.52). EX + SC had a significantly shorter length of hospital stay ( P = 0.05; ES = 1.38) than SC, and a shorter length of hospital stay was associated with decreased sugar intake ( r = 0.55, P = 0.04). Decreased AIx@75 tAUC significantly correlated with improved whole-body insulin sensitivity ( r = -0.59, P = 0.03) and glucose tAUC ( r = 0.57, P = 0.04)., Conclusion: EX with SC for 30 days prior to bariatric surgery may be important for cardiometabolic health, quality of life, and surgical outcomes in the bariatric patient., (Copyright © 2020 Gilbertson, Eichner, Khurshid, Rexrode, Kranz, Weltman, Hallowell and Malin.)
Published: 2020
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11. Exercise improves adiposopathy, insulin sensitivity and metabolic syndrome severity independent of intensity.

Author: Heiston EM, Eichner NZ, Gilbertson NM, and Malin SK
Subjects: Adiponectin metabolism, Body Mass Index, Energy Metabolism physiology, Fasting physiology, Female, Glucose Tolerance Test, High-Intensity Interval Training, Humans, Leptin metabolism, Male, Middle Aged, Obesity physiopathology, Overweight physiopathology, Oxygen Consumption physiology, Prediabetic State physiopathology, Weight Loss physiology, Adipose Tissue physiopathology, Exercise physiology, Insulin Resistance physiology, Metabolic Syndrome physiopathology
Abstract: New Findings: What is the central question of this study? What are the effects of work-matched continuous versus high-intensity interval training for 2 weeks on adiposopathy and cardiometabolic risk in obese adults with prediabetes? What is the main finding and its importance? Independent of intensity, short-term exercise improves adiposopathy and insulin sensitivity. While both exercise intensities reduced fasting leptin concentrations and metabolic syndrome severity, only interval training elevated total adiponectin. In contrast to previous work, neither condition altered high-molecular weight adiponectin. Collectively, these data suggest that short-term exercise can improve adipokine profiles, which may aid in reducing cardiometabolic risk prior to clinically meaningful weight loss in adults with prediabetes., Abstract: Individuals with prediabetes who are overweight and obese are at an increased risk of developing endocrine disruption of fat tissue, known as adiposopathy. While short-term exercise improves adipokine profiles, the effects of exercise intensity when matched for energy expenditure on adiposopathy are unknown. We hypothesized that high-intensity exercise would elicit greater changes in adiposopathy compared to moderate exercise. Twenty-eight overweight and obese adults (age: 60.9 ± 8.4 years; BMI: 33.0 ± 5.4 kg m -2 ) with prediabetes were randomized to twelve 60-min sessions of either moderate-continuous (CONT; n = 14) or high-intensity interval (INT; n = 14) exercise training. Total and high molecular weight (HMW) adiponectin and leptin were collected to assess adiposopathy (ratio of total adiponectin to leptin; A/L). Insulin sensitivity (SI IS ) was determined using a 75 g oral glucose tolerance test before and after training. Cardiometabolic risk factors were measured and a z-score was calculated to determine metabolic syndrome (MetS) severity. CONT and INT increased A/L (P < 0.01) and decreased leptin (P < 0.01) and MetS severity (P = 0.04). Neither intervention altered circulating levels of HMW adiponectin (P = 0.76) and only INT increased total adiponectin levels (P = 0.02). Both intensities increased insulin sensitivity (P < 0.01), which was associated with improvements in A/L (r = 0.47, P = 0.01). Additionally, increases in A/L tended to relate to decreased MetS severity (r = -0.36, P = 0.09). Short-term exercise intensity, when matched for energy expenditure, does not differentially affect improvements in adiposopathy in overweight and obese adults with prediabetes. Further, 12 bouts of exercise improved insulin sensitivity and MetS severity, suggesting that improving adipokine profiles may aid in reducing cardiometabolic risk., (© 2020 The Authors. Experimental Physiology © 2020 The Physiological Society.)
Published: 2020
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12. Interval Exercise Lowers Circulating CD105 Extracellular Vesicles in Prediabetes.

Author: Eichner NZM, Gilbertson NM, Heiston EM, Musante L, LA Salvia S, Weltman A, Erdbrugger U, and Malin SK
Subjects: Blood Glucose metabolism, Body Mass Index, Cardiorespiratory Fitness physiology, Diet, Humans, Middle Aged, Obesity metabolism, Obesity therapy, Vascular Stiffness physiology, Endoglin blood, Exercise Therapy methods, Extracellular Vesicles metabolism, High-Intensity Interval Training, Prediabetic State blood, Prediabetic State therapy
Abstract: Background: Extracellular vesicles (EV) are purported to mediate type 2 diabetes and CVD risk and development. Physical activity and a balanced diet reduce disease risk, but no study has tested the hypothesis that short-term interval (INT) training would reduce EV compared with continuous (CONT) exercise in adults with prediabetes., Methods: Eighteen obese adults (age, 63.8 ± 1.5 yr; body mass index, 31.0 ± 1.3 kg·m) were screened for prediabetes using American Diabetes Association criteria (75 g oral glucose tolerance test). Subjects were randomized to INT (n = 10, alternating 3-min intervals at 90% and 50% HRpeak, respectively) or CONT (n = 8, 70% HRpeak) training for 12 supervised sessions over 13 d for 60 min·d. Cardiorespiratory fitness (V˙ O2peak), weight (kg), as well as ad libitum dietary intake were assessed and arterial stiffness (augmentation index via applanation tonometry) was calculated using total AUC during a 75-g oral glucose tolerance test performed 24 h after the last exercise bout. Total EV, platelet EV (CD31/CD41), endothelial EV (CD105; CD31/ CD41), platelet endothelial cell adhesion molecule (PECAM) (CD31), and leukocyte EV (CD45; CD45/CD41) were analyzed via imaging flow cytometry preintervention/postintervention., Results: The INT exercise increased V˙O2peak (P = 0.04) compared with CONT training. Although training had no effect on platelet or leukocyte EV, INT decreased Annexin V- endothelial EV CD105 compared with CONT (P = 0.04). However, after accounting for dietary sugar intake, the intensity effect was lost (P = 0.18). Increased ad libitum dietary sugar intake after training was linked to elevated AV+ CD105 (r = 0.49, P = 0.06) and AV- CD45 (r = 0.59, P = 0.01). Nonetheless, increased V˙O2peak correlated with decreased AV+ CD105 (r = -0.60, P = 0.01)., Conclusions: Interval exercise training decreases endothelial-derived EV in adults with prediabetes. Although increased sugar consumption may alter EV after a short-term exercise intervention, fitness modifies EV count.
Published: 2020
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13. Impact of Short-Term Continuous and Interval Exercise Training on Endothelial Function and Glucose Metabolism in Prediabetes.

Author: Malin SK, Gilbertson NM, Eichner NZM, Heiston E, Miller S, and Weltman A
Subjects: Area Under Curve, Blood Pressure, Female, Humans, Male, Middle Aged, Vascular Cell Adhesion Molecule-1 blood, Vasodilation physiology, Endothelium, Vascular physiopathology, Exercise physiology, Glucose metabolism, Prediabetic State physiopathology
Abstract: Introduction: The impact of interval (INT) vs. continuous (CONT) exercise training on endothelial function in relation to glucose metabolism prior to clinically meaningful weight loss is unknown in adults with prediabetes., Methods: Twenty-six subjects with prediabetes (60 ± 1 y; 33 ± 1 kg/m 2 ; 2-hr-PG OGTT: 145 ± 7 mg/dl) were randomized to 60 min of CONT ( n = 12; 70% of HR peak ) or work-matched INT exercise training ( n = 14; alternating 3 min at 90 and 50% HR peak ) for 2 weeks. Aerobic fitness (VO 2peak ) and body composition (bioelectrical impedance) were assessed before and after training. Flow-mediated dilation (FMD) was measured during a 2 h 75 g OGTT (0, 60, and 120 min) to assess endothelial function. Postprandial FMD was calculated as incremental area under the curve (iAUC). Glucose tolerance and insulin were also calculated by iAUC. Fasting plasma VCAM, ICAM, and hs-CRP were also assessed as indicators of vascular/systemic inflammation., Results: Both interventions increased VO 2peak ( P = 0.002) but had no effect on body fat ( P = 0.20). Although both treatments improved glucose tolerance ( P = 0.06) and insulin iAUC ( P = 0.02), VCAM increased ( P = 0.01). There was no effect of either treatment on ICAM, hs-CRP, or fasting as well as postprandial FMD. However, 57% of people improved fasting and iAUC FMD following CONT compared with only 42% after INT exercise (each: P = 0.04). Elevated VCAM was linked to blunted fasting FMD after training ( r = -0.38, P = 0.05). But, there was no correlation between fasting FMD or postprandial FMD with glucose tolerance ( r = 0.17, P = 0.39 and r = 0.02, P = 0.90, respectively) or insulin iAUC following training ( r = 0.34, P = 0.08 and r = 0.04, P = 0.83, respectively)., Conclusion: Endothelial function is not improved consistently after short-term training, despite improvements in glucose and insulin responses to the OGTT in obese adults with prediabetes., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2019 Steven K. Malin et al.)
Published: 2019
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14. Two Weeks of Interval Training Enhances Fat Oxidation during Exercise in Obese Adults with Prediabetes.

Author: Gaitán JM, Eichner NZM, Gilbertson NM, Heiston EM, Weltman A, and Malin SK
Subjects: Aged, Blood Glucose metabolism, Body Mass Index, Cardiorespiratory Fitness physiology, Energy Metabolism physiology, Female, Glucose Tolerance Test, Humans, Male, Middle Aged, Obesity blood, Obesity complications, Oxidation-Reduction, Oxygen Consumption physiology, Perception physiology, Physical Exertion physiology, Prediabetic State blood, Prediabetic State complications, Adipose Tissue metabolism, High-Intensity Interval Training, Obesity metabolism, Prediabetic State metabolism
Abstract: Prediabetes is associated with impaired oxidative capacity and altered substrate utilization during exercise. The effects of continuous (CONT) versus interval (INT) exercise training on fat oxidation during an acute exercise bout at the same absolute and relative intensities are unknown in this population. Obese females/males (n = 17, n = 5) with prediabetes (BMI 32.2 ± 1.2 kg·m -2 ; age 62.8 ± 1.6 y; fasting glucose 103.4 ± 1.6 mg·dL -1 ; 2-hour glucose 153.7 ± 7.1 mg·dL -1 ; VO 2 peak 19.9 ± 1.0 mL·kg -1 ·min -1 ) were screened with a 75g OGTT. Subjects completed a peak oxygen consumption test and a submaximal exercise substrate utilization test consisting of 5min stages at absolute (30W) and relative (70%HR peak ) intensities before and after randomization to 12 sessions (60min each) of CONT (70% HR peak ) or INT (alternating 3min 90% HR peak , 3min 50% HR peak ) over a two-week period. Body mass decreased and VO 2 peak increased more after INT than CONT (INT: -0.6 ± 0.2 kg, CONT: -0.1 ± 0.2 kg; p = 0.04; INT: 1.9 ± 0.6 mL/kg/min, CONT: 0.1 ± 0.6 mL·kg -1 ·min -1 ; p = 0.04). Training increased fat oxidation by 0.7 ± 0.2 mL·kg -1 ·min -1 during the absolute intensity test (p < 0.001), independent of intensity. During the relative intensity test, fat oxidation increased more after INT than CONT (INT: 1.3 ± 0.4 mL·kg -1 ·min -1 , CONT: 0.3 ± 0.3 mL·kg -1 ·min -1 ; p = 0.03), with no difference in exercise energy expenditure between groups. Enhanced fat oxidation during the relative test was correlated with increased VO 2 peak (r = 0.53 p = 0.01). High intensity INT training enhances fat oxidation during the same relative intensity exercise in people with prediabetes., (© Journal of Sports Science and Medicine.)
Published: 2019

15. A low-calorie diet with or without interval exercise training improves adiposopathy in obese women.

Author: Gilbertson NM, Eichner NZM, Heiston EM, Gaitán JM, Francois ME, Mehaffey JH, Hassinger TE, Hallowell PT, Weltman A, and Malin SK
Subjects: Adipokines blood, Anaerobic Threshold, Body Composition, Female, Glucose Tolerance Test, Heart Rate, Humans, Insulin Resistance, Middle Aged, Obesity diet therapy, Oxygen Consumption, Physical Fitness, Weight Loss, Adiposity, Diet, Reducing, Exercise Therapy, High-Intensity Interval Training, Obesity therapy
Abstract: The objective of this study was to test if a low-calorie diet plus interval exercise (LCD+INT) improves adiposopathy, an endocrine dysfunction, when compared with an energy-deficit-matched LCD in obese women. Subjects (age: 48.2 ± 2.4 years, body mass index: 37.8 ± 1.3 kg/m 2 ) were randomized to a 13-day LCD ( n = 12; mixed meals of ∼1200 kcal/day) or LCD+INT ( n = 12; 12 sessions of 60 min/day alternating 3 min at 50% and 90% peak heart rate). Exercise was estimated to expend 350 kcal per oxygen uptake-heart rate regression analysis and individuals were refed calories expended to match energy availability between groups. Absolute (post - pre caloric intake) and relative (total daily and exercise energy expenditure relative to calorie intake) energy deficits were calculated. Fitness (peak oxygen uptake) and body composition (BodPod; Cosmed USA Inc.) were measured and a 120-min, 75g oral glucose tolerance test was performed at pre- and post-intervention to assess adiposopathy (i.e., ratio of high molecular weight-adiponectin to leptin) and estimate insulin sensitivity. LCD and LCD+INT had similar absolute ( P = 0.55) and relative ( P = 0.76) energy deficits. LCD and LCD+INT had similar reductions in fat mass (both P < 0.001), despite LCD inducing greater weight loss ( P = 0.02) than LCD+INT. Both treatments improved adiposopathy ( P = 0.003) and peripheral insulin sensitivity ( P = 0.02). Absolute energy deficit correlated to improved adiposopathy ( r = - 0.41, P = 0.05), and absolute and relative energy deficits were associated with increased insulin sensitivity ( r = -0.47, P = 0.02; and r = -0.40, P = 0.05, respectively), independent of body composition changes and increased peak oxygen uptake. Taken together, LCD, with or without INT, improves adiposopathy in relation to insulin sensitivity in obese women, suggesting that a short-term energy deficit is key for reducing risk of type 2 diabetes.
Published: 2019
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16. Endothelial function following interval exercise plus low-calorie diet treatment in obese females.

Author: Gilbertson NM, Miller SL, Eichner NZM, and Malin SK
Subjects: Adult, Blood Glucose metabolism, Body Composition physiology, Brachial Artery physiopathology, Combined Modality Therapy, Female, Glucose Tolerance Test, Humans, Insulin blood, Middle Aged, Obesity blood, Obesity physiopathology, Physical Fitness physiology, Vasodilation physiology, Caloric Restriction, Endothelium, Vascular physiopathology, High-Intensity Interval Training, Obesity therapy
Abstract: We determined if interval exercise plus a low-calorie diet (LCD + INT) increases endothelial function more than an energy-matched LCD. Obese women (47.2 ± 2.6y, 37.5 ± 1.3kg/m 2 ) were randomized to 13 days of a LCD (n = 12; mixed meals of ~ 1200kcal/d) or LCD + INT (n = 13; 12 supervised 60-min INT bouts of 3 min at 90% and 50% HR peak ). LCD + INT subjects received 350kcal postexercise to equate energy availability with LCD. Fitness (VO 2 peak) and body composition (BodPod) were determined and a 120 min, 75 g oral glucose tolerance test was performed to examine fasting and postprandial flow-mediated dilation (FMD, endothelial function), respiratory exchange ratio (RER) via indirect calorimetry as well as glucose and insulin incremental area under the curve (iAUC 120min ). LCD + INT increased VO 2 peak (P = 0.02) compared with LCD, and both treatments decreased fat mass (P < 0.001) and insulin iAUC 120min (P = 0.03). There was no overall treatment effect on fasting or iAUC 120min FMD. However, in participants who increased fasting endothelial function after each treatment (Δ > 50%; LCD n = 5, LCD + INT n = 7), LCD + INT increased fasted (P = 0.005) and decreased iAUC 120min (P = 0.003) FMD compared with LCD. Enhanced fitness correlated with increased fasting FMD (r = 0.43, P = 0.03) and diminished FMD iAUC 120min (r = -0.44, P = 0.03). Decreased FMD iAUC 120min correlated with reduced glucose iAUC 120min (r = 0.64, P = 0.001) as well as increased 60-min RER (r = -0.42, P = 0.04). Low baseline fasting and iAUC 120min FMD was also linked to enhanced fasting and iAUC 120min FMD post-treatment (r = -0.71, P < 0.001; r = -0.89, P < 0.001, respectively). In conclusion, increasing fitness via INT may increase the effect of LCD on lowering cardiovascular disease risk in obese women., (© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.)
Published: 2019
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17. Effects of Feedback Type and Personality on 2,000-m Ergometer Performance in Female Varsity Collegiate Rowers.

Author: Stine KA, Moxey JR, Gilbertson NM, Malin SK, and Weltman AL
Subjects: Athletes, Ergometry, Exercise Test, Female, Humans, Oxygen Consumption physiology, Young Adult, Athletic Performance physiology, Body Composition physiology, Feedback, Personality physiology, Water Sports physiology
Abstract: Stine, KA, Moxey, JR, Gilbertson, NM, Malin, SK, and Weltman, AL. Effects of feedback type and personality on 2,000-m ergometer performance in female varsity collegiate rowers. J Strength Cond Res 33(8): 2170-2176, 2019-Rowing performance is routinely tested on ergometers, involving visual cues and verbal encouragement, whereas on-water rowing lacks the visual cues. Personality is also hypothesized to influence rowing performance. The purpose was to examine the effects of visual and verbal feedback and to determine the impact of personality on performance. Thirty-eight female collegiate rowers (body mass 75.0 ± 5.7 kg and height 176.6 ± 5.0 cm) were recruited. Participants were asked to complete a progressive continuous graded exercise test, body composition analysis, personality questionnaire (Neo five-factor inventory, version 3), and 2 randomly ordered 2000-m ergometer tests: routine verbal and visual vs. verbal only. Differences between the 2,000-m tests were analyzed with a paired t-test. The relationships among VO2max, body composition, and 2,000-m performance were analyzed with Pearson's Correlations. A 2 × 2 analysis of variance analyzed neuroticism, openness, agreeableness, and conscientiousness to investigate how personality impacted 2,000-m performance. Statistical significance was set to p ≤ 0.05. The combination of visual plus verbal feedback trended toward improving performance compared with the verbal feedback alone (430.3 ± 8.6, 431.6 ± 8.9 seconds, respectively). High neuroticism negatively impacted 2,000-m performance (p ≤ 0.05). Conscientiousness and agreeableness trended toward improved performance: as conscientiousness and agreeableness increase, time decreases. We conclude that the combination of verbal plus visual feedback tends to yield better 2,000-m performance and that highly conscientious, highly agreeable, and low neurotic athletes outperform their respective counterparts. Using visual plus verbal encouragement while simultaneously targeting personality factors may be a novel strategy to optimize rowers' training.
Published: 2019
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18. Combining supervised run interval training or moderate-intensity continuous training with the diabetes prevention program on clinical outcomes.

Author: Gilbertson NM, Mandelson JA, Hilovsky K, Akers JD, Hargens TA, Wenos DL, and Edwards ES
Subjects: Adolescent, Adult, Aged, Blood Glucose analysis, Body Composition, Humans, Male, Middle Aged, Physical Conditioning, Human adverse effects, Physical Fitness, Pleasure, Physical Conditioning, Human methods, Prediabetic State therapy, Running
Abstract: Purpose: The present study was designed to evaluate the 16 weeks diabetes prevention program (DPP) combined with instructed run sprint interval training (INT) or moderate-intensity continuous training (MICT) on glycemic control, body composition, fitness, exercise adherence, and perceived exercise enjoyment in sedentary, adults with prediabetes., Methods: Participants completed three weekly supervised sessions of INT (4-10 bouts of 30 s maximal sprints followed by a 4 min active recovery) or MICT (30-60 min at 45-55% HRR) exercise coupled with the DPP for 16 weeks. At baseline, 8 and 16 weeks, participants completed fitness and clinical assessments as well as questionnaires to assess group and time differences., Results: Twenty-nine study participants (INT n = 17, MICT n = 12) were randomized, however, significantly (p = 0.024) more participants withdrew from the INT (n = 11) than MICT (n = 4) treatment. There was no significant difference between groups in perceived exercise enjoyment, but, the MICT group significantly improved their perceived exercise enjoyment (10.8 ± 14.2; p = 0.021) from baseline to 16 weeks. Both INT and MICT groups decreased their body weight (2.0 ± 0.8 vs. - 5.5 ± 1.4 kg; p < 0.001), BMI (- 0.6 ± 0.3 vs. - 2.1 ± 0.5 kg/m 2 ; p < 0.001), body fat mass (1.4 ± 0.6 vs. - 4.2 ± 1.0 kg; p < 0.001), fasting glucose (- 0.09 ± 0.01 vs. - 0.18 ± 0.02 mmol/L; p = 0.020), and HbA1c (- 0.21 ± 0.09 vs. - 0.12 ± 0.12%; p = 0.001), respectively, however, the MICT had greater reductions (GxT: p ≤ 0.05) in body weight, BMI, and body fat than the INT group., Conclusion: Sixteen weeks of MICT is adhered to better and elicits greater improvements in body composition than INT. Nevertheless, both interventions similarly reduced fasting glucose and HbA1c in adults with prediabetes, suggesting either treatment could be effective for T2D prevention.
Published: 2019
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19. An Oral Glucose Load Decreases Postprandial Extracellular Vesicles in Obese Adults with and without Prediabetes.

Author: Eichner NZM, Gilbertson NM, Musante L, La Salvia S, Weltman A, Erdbrügger U, and Malin SK
Subjects: Blood Platelets, Body Composition, Case-Control Studies, Extracellular Vesicles physiology, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Extracellular Vesicles drug effects, Glucose metabolism, Glucose Tolerance Test, Obesity metabolism, Postprandial Period, Prediabetic State metabolism
Abstract: Although extracellular vesicles (EVs) are a novel biomediator of type 2 diabetes (T2D) and cardiovascular disease (CVD), the effects of hyperglycemia on EVs in humans is unknown. We tested the hypothesis that a 75-g oral glucose tolerance test (OGTT) would promote changes in EVs in relation to CVD risk. Twenty-five obese adults (Age: 52.4 ± 3.2 year, BMI: 32.5 ± 1.2 kg/m²) were screened for normal glucose tolerance (NGT, n = 8) and prediabetes (PD, n = 17) using American Diabetes Association criteria (75 g OGTT and/or HbA1c). Body composition (bioelectrical impedance) and fitness (VO₂peak) were measured. Arterial stiffness (augmentation index; AIx) was measured at 0, 60- and 120-min while insulin, glucose, and free fatty acids were evaluated every 30 min during the OGTT to assess CVD risk. Annexin V positive (AV+) and Annexin V negative (AV-) total EVs, platelet EVs (CD31⁺/CD41⁺; CD41⁺), leukocyte EVs (CD45⁺; CD45⁺/CD41 - ), platelet endothelial cell adhesion molecule (PECAM) (CD31⁺) and endothelial EVs (CD 31⁺/CD41 - ; CD105⁺) were collected at 0 and 120 min. There were no differences in age, BMI, or body fat between NGT and PD (all P > 0.63). Total EVs, AV+ CD31 + (PECAM), and AV+ CD31⁺/CD41 - (endothelial) EVs decreased after the OGTT ( P ≤ 0.04). Circulating insulin at 2-h correlated with elevated post-prandial AV- CD45⁺ ( r = 0.48, P = 0.04) while arterial stiffness related to reduced total EVs ( r = -0.49, P = 0.03) and AV+CD41⁺ (platelet) ( r = -0.52, P = 0.02). An oral glucose load lowers post-prandial total, platelet, and endothelial EVs in obese adults with NGT and prediabetes in relation to CVD risk., Competing Interests: The authors declare no conflict of interest.
Published: 2019
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20. Two weeks of exercise training intensity on appetite regulation in obese adults with prediabetes.

Author: Heiston EM, Eichner NZM, Gilbertson NM, Gaitán JM, Kranz S, Weltman A, and Malin SK
Subjects: Body Mass Index, Body Weight physiology, Energy Intake physiology, Energy Metabolism physiology, Fasting metabolism, Fasting physiology, Female, Ghrelin metabolism, Glucagon-Like Peptide 1 metabolism, Glucose Tolerance Test methods, High-Intensity Interval Training methods, Humans, Male, Middle Aged, Obesity metabolism, Oxygen Consumption physiology, Postprandial Period physiology, Weight Loss physiology, Appetite physiology, Appetite Regulation physiology, Exercise physiology, Obesity physiopathology, Prediabetic State physiopathology
Abstract: No short-term exercise data exist testing whether training intensity modifies hormonal and perceived appetite in obese adults with prediabetes. Therefore, we compared the effects of short-term moderate-continuous (CONT) vs. high-intensity interval (INT) training on appetite regulation. Twenty-eight obese adults [age: 61.3 ± 1.5 yr; body mass index (BMI): 33.2 ± 1.1 kg/m 2 ] with prediabetes were randomized to work-matched CONT ( n = 14) or INT ( n = 14) training for 2 wk. Plasma acylated ghrelin (AG), des-acylated ghrelin (dAG), active glucagon-like peptide-1 (GLP-1), and insulin were measured at 0, 30, and 60 min of a 75-g oral glucose tolerance test (OGTT) before and after training. Visual analog scales were administered at 0 and 120 min during the OGTT to examine perceived appetite. Three-day food logs were collected before and after testing to assess ad libitum diet. CONT and INT increased peak oxygen consumption ( P < 0.01) and decreased BMI ( P < 0.01). Although neither intervention altered fasting levels of AG ( P = 0.94), dAG ( P = 0.36), or insulin ( P = 0.67), CONT raised GLP-1 compared with INT ( P = 0.05). Exercise training did not affect postprandial suppression of AG ( P = 0.81) and dAG ( P = 0.67) or stimulation of GLP-1 ( P = 0.67) and insulin ( P = 0.32). Both interventions tended to decrease total energy and protein intake ( P = 0.09 and P = 0.05, respectively), despite no change in fasting hunger ( P = 0.88) and reduced perceived fullness at 120 min during the OGTT ( P = 0.05). We conclude that 2 wk of exercise training intensity does not modulate appetite-regulatory hormones in obese adults with prediabetes. Although perceived fullness to the OGTT was reduced after exercise, CONT and INT decreased energy intake, suggesting that exercise does not elicit compensatory appetite behavior to gain weight. NEW & NOTEWORTHY Adults with prediabetes are at risk for appetite dysregulation. Although exercise promotes weight management, it is unclear whether moderate-continuous or high-intensity interval training is more beneficial for appetite regulation. We show that 2 wk of exercise, independent of intensity, does not alter postprandial appetite hormones or hunger, despite slight reductions in food intake and weight. These data support exercise as an effective method to induce negative energy balance without compensatory weight gain.
Published: 2019
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21. Postprandial augmentation index is reduced in adults with prediabetes following continuous and interval exercise training.

Author: Eichner NZM, Gaitán JM, Gilbertson NM, Khurshid M, Weltman A, and Malin SK
Subjects: Body Mass Index, Female, Glucose metabolism, Glucose Tolerance Test methods, Heart Rate physiology, Humans, Insulin Resistance physiology, Middle Aged, Pulse Wave Analysis methods, Vascular Stiffness physiology, Exercise physiology, Postprandial Period physiology, Prediabetic State physiopathology
Abstract: New Findings: What is the central question of this study? We compared high-intensity interval versus continuous training on fasting and postprandial arterial stiffness in people with prediabetes. What is the main finding and its importance? We show, for the first time, that exercise improves the augmentation index during the postprandial state, but not the fasted state, in adults with prediabetes. However, the fasted augmentation index improved in relationship to exercise dose, as assessed by kilocalories per session. Collectively, these findings suggest that short-term exercise can improve arterial compliance in adults with prediabetes. Therefore, lifestyle interventions designed to reduce arterial stiffness could have considerable clinical impact., Abstract: People with prediabetes have elevated risk for cardiovascular disease, in part, owing to arterial stiffness mediated by low insulin sensitivity. However, the effect the intensity and/or amount (i.e. kilocalories per session) of short-term exercise training on fasting and postprandial arterial stiffness is unknown. We tested the hypothesis that increased intensity and dose (i.e. amount) of exercise would be correlated with reduced fasting and postprandial arterial stiffness in obese adults with prediabetes. After randomization, 31 adults (age 61.4 ± 8.3 years, body mass index 32.1 ± 5.4 kg m -2 ) with prediabetes performed supervised continuous (CONT; n = 17; 70% of peak heart rate) or interval (INT; n = 14; 3 min at 50% of peak heart rate and 3 min at 90% of peak heart rate) cycling training for 60 min day -1 over 2 weeks. The amount of exercise was calculated using regression equations derived from oxygen uptake ( V ̇ O 2 ) and heart rate. Arterial stiffness [augmentation index (AI) and cartoid-femoral pulse wave velocity], insulin and glucose were determined during a 180 min 75 g oral glucose tolerance test (OGTT) and analysed by the total area under the curve (tAUC) pre- versus post-training. The simple index of insulin sensitivity, (SI IS )OGTT, was calculated; aerobic fitness (peak V ̇ O 2 ) and body mass were also assessed. Short-term training had no effect on weight but did improve peak V ̇ O 2 (P = 0.003), glucose tAUC 180min (P = 0.01) and insulin sensitivity (P = 0.002), independent of intensity. The CONT and INT exercise significantly reduced AI 2 h postprandial (P = 0.008) and tAUC 180min (P = 0.03). Reductions in fasted AI were related to exercise dose (trend: r = -0.37, P = 0.055). Increased peak V ̇ O 2 was linked to reduced fasted (r = -0.47, P = 0.01) and tAUC 180min AI (r = -0.39, P = 0.05). Decreased AI tAUC 180min was correlated with increased insulin sensitivity (r = -0.50, P = 0.009). Short-term CONT and INT training reduced postprandial arterial stiffness comparably in adults with prediabetes., (© 2018 The Authors. Experimental Physiology © 2018 The Physiological Society.)
Published: 2019
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22. Impact of short-term exercise training intensity on β-cell function in older obese adults with prediabetes.

Author: Malin SK, Francois ME, Eichner NZM, Gilbertson NM, Heiston EM, Fabris C, and Breton M
Subjects: Female, Gastric Inhibitory Polypeptide blood, Glucagon-Like Peptide 1 blood, Glucose Tolerance Test, Humans, Male, Middle Aged, Prediabetic State blood, High-Intensity Interval Training, Insulin Secretion, Insulin-Secreting Cells physiology, Obesity complications, Prediabetic State immunology
Abstract: The effect of work-matched exercise intensity on β-cell function is unknown in people with prediabetes before clinical weight loss. We determined if short-term moderate continuous (CONT) vs. high-intensity interval (INT) exercise increased β-cell function. Thirty-one subjects (age: 61.4 ± 2.5 yr; body mass index: 32.1 ± 1.0 kg/m 2 ) with prediabetes [American Diabetes Association criteria, 75-g oral glucose tolerance test (OGTT)] were randomized to work-matched CONT (70% HR peak ) or INT (3 min 90% HR peak and 3 min 50% HR peak ) exercise for 60 min/day over 2 wk. A 75-g 2-h OGTT was conducted after an overnight fast, and plasma glucose, insulin, C-peptide, and free fatty acids were determined for calculations of skeletal muscle [oral minimal model (OMM)], hepatic (homeostatic model of insulin resistance), and adipose (Adipose-IR) insulin sensitivity. β-Cell function was defined from glucose-stimulated insulin secretion (GSIS, deconvolution modeling) and the disposition index (DI). Glucagon-like polypeptide-1 [GLP-1(active)] and glucose-dependent insulinotropic polypeptide (GIP) were also measured during the OGTT, along with peak oxygen consumption and body composition. CONT and INT increased skeletal muscle- but not hepatic- or adipose-derived DI ( P < 0.05). Although both treatments tended to reduce fasting GLP-1(active) ( P = 0.08), early phase GLP-1(active) increased post-CONT and INT training ( P < 0.001). Interestingly, CONT exercise increased fasting GIP compared with decreases in INT ( P = 0.02). Early and total-phase skeletal muscle DI correlated with decreased total glucose area under the curve ( r = -0.52, P = 0.002 and r = -0.50, P = 0.003, respectively). Independent of intensity, short-term training increased pancreatic function adjusted to skeletal muscle in relation to improved glucose tolerance in adults with prediabetes. Exercise also uniquely affected GIP and GLP-1(active). Further work is needed to elucidate the dose-dependent mechanism(s) by which exercise impacts glycemia. NEW & NOTEWORTHY Exercise is cornerstone for reducing blood glucose, but whether high-intensity interval training is better than moderate continuous exercise is unclear in people with prediabetes before weight loss. We show that 2 wk of exercise training, independent of intensity, increased pancreatic function in relation to elevated glucagon-like polypeptide-1 secretion. Furthermore, β-cell function, but not insulin sensitivity, was also correlated with improved glucose tolerance. These data suggest that β-cell function is a strong predictor of glycemia regardless of exercise intensity.
Published: 2018
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23. Glucose Tolerance is Linked to Postprandial Fuel Use Independent of Exercise Dose.

Author: Gilbertson NM, Eichner NZM, Francois M, Gaitán JM, Heiston EM, Weltman A, and Malin SK
Subjects: Adult, Aged, Body Composition, Fasting, Fatty Acids, Nonesterified blood, Female, Glucose Tolerance Test, Humans, Male, Middle Aged, Obesity metabolism, Oxygen Consumption, Blood Glucose analysis, Exercise, Insulin blood, Insulin Resistance, Postprandial Period, Prediabetic State metabolism
Abstract: Purpose: The optimal short-term exercise dose to improve glucose tolerance in relation to metabolic flexibility and/or insulin resistance is unknown. Therefore, we tested if short-term, work-matched continuous (CONT) versus interval (INT) exercise training improves glucose tolerance in part by reducing insulin resistance and increasing metabolic flexibility independent of clinically meaningful fat loss in adults with prediabetes., Methods: Subjects (age = 60.9 ± 1.4 yr, body mass index = 33.5 ± 1.1 kg·m) were screened for prediabetes using the American Diabetes Association criteria (75 g oral glucose tolerance test [OGTT] and/or HbA1c) and were randomized to 60 min·d of supervised CONT (n = 17, 70% HRpeak) or work-matched INT (n = 14; 90% HRpeak for 3 min and 50% HRpeak for 3 min) exercise for 12 bouts. Fitness (V˙O2peak) and body composition were assessed pre- and postintervention. A 180-min 75-g OGTT was performed, and glucose, insulin, and free fatty acids were collected to calculate glucose tolerance (tAUC180min) and whole-body as well as adipose tissue insulin resistance pre- and postintervention. RER (indirect calorimetry) was also measured at 0, 60, 120, and 180 min of the OGTT to assess fasting and postprandial metabolic flexibility., Results: CONT and INT training improved V˙O2peak (L·min; P = 0.001) and glucose tolerance (P = 0.01) and reduced fasting RER (P = 0.006), as well as whole-body and adipose insulin resistance (both P = 0.02) with no effect on body fat (P = 0.18). Increased postprandial RER was correlated with reduced glucose tAUC180min (r = -0.38, P = 0.05) and increased 180-min RER related to decreased whole-body insulin resistance (r = -0.42, P = 0.03)., Conclusion: Independent of exercise dose and fat loss, short-term training improves glucose tolerance in relation to enhanced postprandial fuel use.
Published: 2018
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24. Combining Short-Term Interval Training with Caloric Restriction Improves ß-Cell Function in Obese Adults.

Author: Francois ME, Gilbertson NM, Eichner NZM, Heiston EM, Fabris C, Breton M, Mehaffey JH, Hassinger T, Hallowell PT, and Malin SK
Subjects: Adipose Tissue metabolism, Adipose Tissue physiopathology, Adult, Biomarkers blood, Body Mass Index, Diabetes Mellitus blood, Diabetes Mellitus diagnosis, Diabetes Mellitus physiopathology, Female, Humans, Insulin Resistance, Liver metabolism, Liver physiopathology, Male, Middle Aged, Muscle, Skeletal metabolism, Muscle, Skeletal physiopathology, Obesity blood, Obesity diagnosis, Obesity physiopathology, Time Factors, Treatment Outcome, Virginia, Weight Loss, Blood Glucose metabolism, Caloric Restriction, Diabetes Mellitus prevention & control, High-Intensity Interval Training, Insulin-Secreting Cells metabolism, Obesity therapy
Abstract: Although low-calorie diets (LCD) improve glucose regulation, it is unclear if interval exercise (INT) is additive. We examined the impact of an LCD versus LCD + INT training on ß-cell function in relation to glucose tolerance in obese adults. Twenty-six adults (Age: 46 ± 12 year; BMI 38 ± 6 kg/m²) were randomized to 2-week of LCD (~1200 kcal/day) or energy-matched LCD + INT (60 min/day alternating 3 min at 90 and 50% HRpeak). A 2 h 75 g oral glucose tolerance test (OGTT) was performed. Insulin secretion rates (ISR) were determined by deconvolution modeling to assess glucose-stimulated insulin secretion ([GSIS: ISR/glucose total area under the curve (tAUC)]) and ß-cell function (Disposition Index [DI: GSIS/IR]) relative to skeletal muscle (Matsuda Index), hepatic (HOMA-IR) and adipose (Adipose-IR fasting ) insulin resistance (IR). LCD + INT, but not LCD alone, reduced glucose and total-phase ISR tAUC (Interactions: p = 0.04 and p = 0.05, respectively). Both interventions improved skeletal muscle IR by 16% ( p = 0.04) and skeletal muscle and hepatic DI (Time: p < 0.05). Improved skeletal muscle DI was associated with lower glucose tAUC ( r = -0.57, p < 0.01). Thus, LCD + INT improved glucose tolerance more than LCD in obese adults, and these findings relate to ß-cell function. These data support LCD + INT for preserving pancreatic function for type 2 diabetes prevention.
Published: 2018
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25. Low cardiorespiratory fitness is associated with higher extracellular vesicle counts in obese adults.

Author: Eichner NZM, Gilbertson NM, Gaitan JM, Heiston EM, Musante L, LaSalvia S, Weltman A, Erdbrügger U, and Malin SK
Subjects: Aged, Annexin A5 metabolism, Blood Platelets metabolism, Cross-Sectional Studies, Endothelial Cells metabolism, Extracellular Vesicles ultrastructure, Female, Humans, Leukocytes metabolism, Male, Middle Aged, Retrospective Studies, Cardiorespiratory Fitness, Extracellular Vesicles metabolism, Obesity metabolism, Obesity physiopathology
Abstract: Low cardiorespiratory fitness (CRF) is associated with cardiovascular disease (CVD) independent of obesity. Extracellular vesicles (EVs) are a novel target of CVD, however, it remains unknown if obese individuals with very poor fitness (VPF) have elevated EVs versus people with poor fitness (PF). Thus, we tested whether VPF was associated with greater EV subtypes in obese adults. Subjects with VPF (n = 13, VO 2 peak: 15.4 ± 0.6 mL/kg/min, BMI: 34.1 ± 1.7 kg/m 2 ) and PF (n = 13, VO 2 peak: 25.9 ± 3.0 mL/kg/min, BMI: 32.1 ± 1.2 kg/m 2 ) were compared in this cross-sectional study. After an overnight fast, AnnexinV (AV) +/- platelet (CD31 + /CD41 + ), leukocyte (CD45 + /CD41 - ), and endothelial EVs (CD105 + , CD31 + /CD41 - ) were analyzed from fresh platelet poor plasma via imaging flow cytometry. Body fat, blood pressure (BP), and glucose tolerance (OGTT) were also tested. Body weight, BP, and circulating glucose were similar between groups, although VPF subjects were older than PF (64.0 ± 2.1 vs. 49.8 ± 4.2 year; P < 0.05). People with VPF, compared with PF, had higher total AV - EVs (P = 0.04), AV - platelet EVs (CD31 + /CD41 + ; P = 0.006), and AV - endothelial EVs (CD31 + /CD41 - ; P = 0.005) independent of age and body fat. Higher AV - platelet and endothelial EVs were associated with lower VO 2 peak (r = -0.56, P = 0.006 and r = -0.55, P = 0.005, respectively). Endothelial-derived AV - /CD31 + /CD41 - EVs were also related to pulse pressure (r = 0.45, P = 0.03), whereas AV - /CD105 was linked to postprandial glucose (r = 0.41, P = 0.04). VPF is associated with higher AnnexinV - total, endothelial, and platelet EVs in obese adults, suggesting that subtle differences in fitness may reduce type 2 diabetes and CVD risk through an EV-related mechanism., (© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.)
Published: 2018
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26. Bariatric Surgery Resistance: Using Preoperative Lifestyle Medicine and/or Pharmacology for Metabolic Responsiveness.

Author: Gilbertson NM, Paisley AS, Kranz S, Weltman A, Kirby JL, Hallowell PT, and Malin SK
Subjects: Exercise physiology, Humans, Insulin Resistance physiology, Obesity, Morbid metabolism, Treatment Outcome, Weight Loss, Anti-Obesity Agents therapeutic use, Bariatric Surgery adverse effects, Combined Modality Therapy methods, Life Style, Obesity, Morbid surgery, Weight Reduction Programs methods
Abstract: Bariatric surgery is an effective and durable treatment for individuals with obesity and its associated comorbidities. However, not all patients meet weight loss and/or cardiometabolic goals following bariatric surgery, suggesting that some people are bariatric surgery resistant. The reason for this resistance is unclear, but potential factors, such as adiposity-derived inflammation, insulin resistance, hyperglycemia, and aerobic fitness prior to surgery, have been related to blunted surgery responsiveness. Exercise, diet, and/or pharmacology are effective at reducing inflammation and improving insulin action as well as physical function. Herein, we present data that supports the novel hypothesis that intervening prior to surgery can enhance disease resolution in people who are resistant to bariatric surgery.
Published: 2017
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26 results on '"Gilbertson NM"'

1. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

2. Block-pulse integrodifference equations.

3. The impact of the COVID-19 pandemic on perceptions of health, well-being, and college experience in Division III student-athletes.

4. Impact of a short-term low calorie diet alone or with interval exercise on quality of life and oxidized phospholipids in obese females.

5. Effect of presurgical aerobic exercise on cardiometabolic health 30 days after bariatric surgery.

6. A Low-Calorie Diet with or without Exercise Reduces Postprandial Aortic Waveform in Females with Obesity.

7. Improving gait efficiency to increase movement and physical activity - The impact of abnormal gait patterns and strategies to correct.

8. Pre-operative aerobic exercise on metabolic health and surgical outcomes in patients receiving bariatric surgery: A pilot trial.

9. Short-term interval exercise suppresses acylated ghrelin and hunger during caloric restriction in women with obesity.

10. Impact of Pre-operative Aerobic Exercise on Cardiometabolic Health and Quality of Life in Patients Undergoing Bariatric Surgery.

11. Exercise improves adiposopathy, insulin sensitivity and metabolic syndrome severity independent of intensity.

12. Interval Exercise Lowers Circulating CD105 Extracellular Vesicles in Prediabetes.

13. Impact of Short-Term Continuous and Interval Exercise Training on Endothelial Function and Glucose Metabolism in Prediabetes.

14. Two Weeks of Interval Training Enhances Fat Oxidation during Exercise in Obese Adults with Prediabetes.

15. A low-calorie diet with or without interval exercise training improves adiposopathy in obese women.

16. Endothelial function following interval exercise plus low-calorie diet treatment in obese females.

17. Effects of Feedback Type and Personality on 2,000-m Ergometer Performance in Female Varsity Collegiate Rowers.

18. Combining supervised run interval training or moderate-intensity continuous training with the diabetes prevention program on clinical outcomes.

19. An Oral Glucose Load Decreases Postprandial Extracellular Vesicles in Obese Adults with and without Prediabetes.

20. Two weeks of exercise training intensity on appetite regulation in obese adults with prediabetes.

21. Postprandial augmentation index is reduced in adults with prediabetes following continuous and interval exercise training.

22. Impact of short-term exercise training intensity on β-cell function in older obese adults with prediabetes.

23. Glucose Tolerance is Linked to Postprandial Fuel Use Independent of Exercise Dose.

24. Combining Short-Term Interval Training with Caloric Restriction Improves ß-Cell Function in Obese Adults.

25. Low cardiorespiratory fitness is associated with higher extracellular vesicle counts in obese adults.

26. Bariatric Surgery Resistance: Using Preoperative Lifestyle Medicine and/or Pharmacology for Metabolic Responsiveness.

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