195 results on '"Gholizadeh S"'
Search Results
2. A review of non-destructive testing methods of composite materials
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Gholizadeh, S.
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- 2016
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3. EE206 Cost of Neuromyelitis Optica Spectrum Disorder Misdiagnosis
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Exuzides, A, primary, Reddy, S, additional, Chang, E, additional, Paydar, C, additional, and Gholizadeh, S, additional
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- 2022
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4. Randomized feasibility trial of the Scleroderma Patient-centered Intervention Network Self-Management (SPIN-SELF) Program.
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Kwakkenbos, L, Østbø, N, Carrier, M-E, Nielson, WR, Fedoruk, C, Levis, B, Henry, RS, Pope, J, Frech, T, Gholizadeh, S, Johnson, SR, Piotrowski, P, Jewett, LR, Gordon, J, Chung, L, Bilsker, D, Tao, L, Turner, KA, Cumin, J, Welling, J, Fortuné, C, Leite, C, Gottesman, K, Sauvé, M, Reyna, TSR, Hudson, M, Larche, M, van Breda, W, Suarez-Almazor, ME, Bartlett, SJ, Malcarne, VL, Mayes, MD, Boutron, I, Mouthon, L, Benedetti, A, Thombs, BD, SPIN Investigators, Kwakkenbos, L, Østbø, N, Carrier, M-E, Nielson, WR, Fedoruk, C, Levis, B, Henry, RS, Pope, J, Frech, T, Gholizadeh, S, Johnson, SR, Piotrowski, P, Jewett, LR, Gordon, J, Chung, L, Bilsker, D, Tao, L, Turner, KA, Cumin, J, Welling, J, Fortuné, C, Leite, C, Gottesman, K, Sauvé, M, Reyna, TSR, Hudson, M, Larche, M, van Breda, W, Suarez-Almazor, ME, Bartlett, SJ, Malcarne, VL, Mayes, MD, Boutron, I, Mouthon, L, Benedetti, A, Thombs, BD, and SPIN Investigators
- Abstract
BACKGROUND: The Scleroderma Patient-centered Intervention Network (SPIN) developed an online self-management program (SPIN-SELF) designed to improve disease-management self-efficacy in people with systemic sclerosis (SSc, or scleroderma). The aim of this study was to evaluate feasibility aspects for conducting a full-scale randomized controlled trial (RCT) of the SPIN-SELF Program. METHODS: This feasibility trial was embedded in the SPIN Cohort and utilized the cohort multiple RCT design. In this design, at the time of cohort enrollment, cohort participants consent to be assessed for trial eligibility and randomized prior to being informed about the trial. Participants in the intervention arm are informed and provide consent, but not the control group. Forty English-speaking SPIN Cohort participants from Canada, the USA, or the UK with low disease-management self-efficacy (Self-Efficacy for Managing Chronic Disease Scale [SEMCD] score ≤ 7) who were interested in using an online self-management program were randomized (3:2 ratio) to be offered the SPIN-SELF Program or usual care for 3 months. Program usage was examined via automated usage logs. User satisfaction was assessed with semi-structured interviews. Trial personnel time requirements and implementation challenges were logged. RESULTS: Of 40 SPIN Cohort participants randomized, 26 were allocated to SPIN-SELF and 14 to usual care. Automated eligibility and randomization procedures via the SPIN Cohort platform functioned properly, except that two participants with SEMCD scores > 7 (scores of 7.2 and 7.3, respectively) were included, which was caused by a system programming error that rounded SEMCD scores. Of 26 SPIN Cohort participants offered the SPIN-SELF Program, only 9 (35%) consented to use the program. Usage logs showed that use of the SPIN-SELF Program was low: 2 of 9 users (22%) logged into the program only once (median = 3), and 4 of 9 (44%) accessed none or only 1 of the 9 program's modules (median = 2)
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- 2022
5. A REVIEW OF IMPACT BEHAVIOUR IN COMPOSITE MATERIALS
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Gholizadeh, Samira, primary and Gholizadeh, S, additional
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- 2022
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6. Damage Analysis and Prediction in Glass Fiber Reinforced Polyester Composite Using Acoustic Emission and Machine Learning
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Gholizadeh, Samira, primary and Gholizadeh, S, additional
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- 2022
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7. Impact behaviours and Non-Destructive Testing (NDT) methods in Carbon Fiber Composites in Aerospace Industry: A Review
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Gholizadeh, Samira, primary and Gholizadeh, S, additional
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- 2022
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8. Damage Analysis and Prediction in Glass Fiber Reinforced Polyester Composite Using Acoustic Emission and Machine Learning
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Gholizadeh, S., primary
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- 2021
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9. PRO75 Demographics and Relapse Profile Correlates with Treatment Change in Neuromyelitis Optica Spectrum Disorder (NMOSD) Patients: Analysis of the Circles Study
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Exuzides, A., primary, Gholizadeh, S., additional, Lewis, K., additional, Palmer, C., additional, Waltz, M., additional, Rose, J., additional, Jolley, A., additional, Behne, J.M., additional, Behne, M.K., additional, Blaschke, T.F., additional, Smith, T.J., additional, Sinnott, J., additional, Cook, L., additional, and Yeaman, M.R., additional
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- 2021
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10. Effects of cosmetic and other camouflage interventions on appearance-related and psychological outcomes among adults with visible differences in appearance: A systematic review
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Gholizadeh, S., Rice, D.B., Carboni-Jiménez, A., Kwakkenbos, L., Boruff, J., Krishnan, A., Malcarne, V.L., Thombs, B.D., Gholizadeh, S., Rice, D.B., Carboni-Jiménez, A., Kwakkenbos, L., Boruff, J., Krishnan, A., Malcarne, V.L., and Thombs, B.D.
- Abstract
Contains fulltext : 231162.pdf (publisher's version ) (Open Access), Objective: Visible differences in appearance are associated with poor social and psychological outcomes. Effectiveness of non-surgical cosmetic and other camouflage interventions is poorly understood. The objective was to evaluate effects of cosmetic and other camouflage interventions on appearance-related outcomes, general psychological outcomes and adverse effects for adults with visible appearance differences. Design: Systematic review. Data sources MEDLINE (Ovid), EMBASE (Ovid), PsycINFO (Ovid) CINAHL and Cochrane Central databases searched from inception to 24 October 2020. Two reviewers independently reviewed titles and abstracts and full texts.Eligibility criteria Randomised controlled trials in any language on non-surgical cosmetic or other camouflage interventions that reported appearance-related outcomes, general psychological outcomes or adverse effects for adults with visible appearance differences. Data extraction and synthesis: Two reviewers independently extracted data, assessed intervention reporting using the Template for Intervention Description and Replication checklist, and assessed risk of bias using the Cochrane risk of bias tool. Outcomes included appearance-related outcomes, general psychological outcomes (eg, depression, anxiety) and adverse effects. Results: One head-to-head trial and five trials with waiting list or routine care comparators were included. All had unclear or high risk of bias in at least five of seven domains. Effect sizes could not be determined for most outcomes due to poor reporting. Between-group statistically significant differences were not reported for any appearance-related outcomes and for only 5 of 25 (20%) other psychological outcomes. Given heterogeneity of populations and interventions, poor reporting and high risk of bias, quantitative synthesis was not possible. Conclusions: Conclusions about effectiveness of non-surgical cosmetic or other camouflage interventions could not be drawn. Well-designed and conduct
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- 2021
11. The Scleroderma Patient-centered Intervention Network Self-Management (SPIN-SELF) Program: protocol for a two-arm parallel partially nested randomized controlled feasibility trial with progression to full-scale trial.
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Nordlund, J, Henry, RS, Kwakkenbos, L, Carrier, M-E, Levis, B, Nielson, WR, Bartlett, SJ, Dyas, L, Tao, L, Fedoruk, C, Nielsen, K, Hudson, M, Pope, J, Frech, T, Gholizadeh, S, Johnson, SR, Piotrowski, P, Jewett, LR, Gordon, J, Chung, L, Bilsker, D, Levis, AW, Turner, KA, Cumin, J, Welling, J, Fortuné, C, Leite, C, Gottesman, K, Sauve, M, Rodríguez-Reyna, TS, Larche, M, van Breda, W, Suarez-Almazor, ME, Wurz, A, Culos-Reed, N, Malcarne, VL, Mayes, MD, Boutron, I, Mouthon, L, Benedetti, A, Thombs, BD, SPIN Investigators, Nordlund, J, Henry, RS, Kwakkenbos, L, Carrier, M-E, Levis, B, Nielson, WR, Bartlett, SJ, Dyas, L, Tao, L, Fedoruk, C, Nielsen, K, Hudson, M, Pope, J, Frech, T, Gholizadeh, S, Johnson, SR, Piotrowski, P, Jewett, LR, Gordon, J, Chung, L, Bilsker, D, Levis, AW, Turner, KA, Cumin, J, Welling, J, Fortuné, C, Leite, C, Gottesman, K, Sauve, M, Rodríguez-Reyna, TS, Larche, M, van Breda, W, Suarez-Almazor, ME, Wurz, A, Culos-Reed, N, Malcarne, VL, Mayes, MD, Boutron, I, Mouthon, L, Benedetti, A, Thombs, BD, and SPIN Investigators
- Abstract
BACKGROUND: Systemic sclerosis (scleroderma; SSc) is a rare autoimmune connective tissue disease. We completed an initial feasibility trial of an online self-administered version of the Scleroderma Patient-centered Intervention Network Self-Management (SPIN-SELF) Program using the cohort multiple randomized controlled trial (RCT) design. Due to low intervention offer uptake, we will conduct a new feasibility trial with progression to full-scale trial, using a two-arm parallel, partially nested RCT design. The SPIN-SELF Program has also been revised to include facilitator-led videoconference group sessions in addition to online material. We will test the group-based intervention delivery format, then evaluate the effect of the SPIN-SELF Program on disease management self-efficacy (primary) and patient activation, social appearance anxiety, and functional health outcomes (secondary). METHODS: This study is a feasibility trial with progression to full-scale RCT, pending meeting pre-defined criteria, of the SPIN-SELF Program. Participants will be recruited from the ongoing SPIN Cohort ( http://www.spinsclero.com/en/cohort ) and via social media and partner patient organizations. Eligible participants must have SSc and low to moderate disease management self-efficacy (Self-Efficacy for Managing Chronic Disease (SEMCD) Scale score ≤ 7.0). Participants will be randomized (1:1 allocation) to the group-based SPIN-SELF Program or usual care for 3 months. The primary outcome in the full-scale trial will be disease management self-efficacy based on SEMCD Scale scores at 3 months post-randomization. Secondary outcomes include SEMCD scores 6 months post-randomization plus patient activation, social appearance anxiety, and functional health outcomes at 3 and 6 months post-randomization. We will include 40 participants to assess feasibility. At the end of the feasibility portion, stoppage criteria will be used to determine if the trial procedures or SPIN-SELF Program need important
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- 2021
12. Assessing differential item functioning for the Social Appearance Anxiety Scale: A Scleroderma Patient-centred Intervention Network (SPIN) Cohort study
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Sommer, S.J., Harel, D., Kwakkenbos, L., Carrier, M.E., Gholizadeh, S., Gottesman, K., Leite, C., Malcarne, V.L., Thombs, B.D., Sommer, S.J., Harel, D., Kwakkenbos, L., Carrier, M.E., Gholizadeh, S., Gottesman, K., Leite, C., Malcarne, V.L., and Thombs, B.D.
- Abstract
Contains fulltext : 226487.pdf (publisher's version ) (Open Access), Objectives: The Social Appearance Anxiety Scale (SAAS) is a 16-item questionnaire developed to evaluate fear of appearance-based evaluation by others. The primary objective of this research was to investigate the existence of differential item functioning (DIF) for the 16 SAAS items, comparing patients who completed the SAAS in English and French, either to confirm that scores are comparable or provide guidance on calculating comparable scores. A secondary research objective was to investigate the existence of DIF based on sex and disease status. A tertiary research objective was to assess DIF related to language, sex, and disease status on the recently developed SAAS-5. Design: This was a cross-sectional analysis using baseline data from patients enrolled in the Scleroderma Patient-centred Intervention Network (SPIN). Setting: SPIN patients included in the present study were enrolled at 43 centres in Canada, USA, UK, France and Australia, with questionnaires completed in April 2014 to July 2019. Participants: 1640 SPIN patients completed the SAAS in French (n=600) or English (n=1040). Primary and secondary measures: The SAAS was collected along with demographic and disease characteristics.Results Six items were identified with statistically significant language-based DIF, four with sex-based DIF and one with disease type-based DIF. However, factor scores before and after accounting for DIF were similar (Pearson correlation >0.99), and individual score differences were small. This was true for both the full and shortened versions of the SAAS.Conclusion SAAS and SAAS-5 scores are comparable across language, sex, and disease-type, despite small differences in how patients respond to some items.
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- 2020
13. The Scleroderma Patient-Centered Intervention Network Self-Management Program: Protocol for a randomized feasibility trial
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Carrier, M.E., Kwakkenbos, L., Nielson, W.R., Fedoruk, C., Nielsen, K., Milette, K., Pope, J., Frech, T., Gholizadeh, S., Hummers, L., Johnson, S.R., Piotrowski, P., Jewett, L.R., Gordon, J.K., Chung, L., Bilsker, D., Turner, K.A., Cumin, J., Welling, J.J.K.C., Fortune, C., Leite, C., Gottesman, K., Sauvé, M., Rodríguez-Reyna, T.S., Hudson, M., Larché, M., Breda, W. van, Suarez-Almazor, M.E., Bartlett, S.J., Malcarne, V.L., Mayes, M.D., Boutron, I., Mouthon, L., Wigley, F.M., Thombs, B.D., Carrier, M.E., Kwakkenbos, L., Nielson, W.R., Fedoruk, C., Nielsen, K., Milette, K., Pope, J., Frech, T., Gholizadeh, S., Hummers, L., Johnson, S.R., Piotrowski, P., Jewett, L.R., Gordon, J.K., Chung, L., Bilsker, D., Turner, K.A., Cumin, J., Welling, J.J.K.C., Fortune, C., Leite, C., Gottesman, K., Sauvé, M., Rodríguez-Reyna, T.S., Hudson, M., Larché, M., Breda, W. van, Suarez-Almazor, M.E., Bartlett, S.J., Malcarne, V.L., Mayes, M.D., Boutron, I., Mouthon, L., Wigley, F.M., and Thombs, B.D.
- Abstract
Contains fulltext : 219726.pdf (publisher's version ) (Open Access), Background: Systemic sclerosis (SSc), or scleroderma, is a rare disease that often results in significant disruptions to activities of daily living and can negatively affect physical and psychological well-being. Because there is no known cure, SSc treatment focuses on reducing symptoms and disability and improving health-related quality of life (HRQoL). Self-management programs are known to increase self-efficacy for disease management in many chronic diseases. The Scleroderma Patient-centered Intervention Network (SPIN) developed a Web-based self-management program (SPIN self-management; SPIN-SELF) to increase self-efficacy for disease management and to improve HRQoL for patients with SSc. Objective: The proposed study aims to assess the feasibility of conducting a full-scale randomized controlled trial (RCT) of the SPIN-SELF program by evaluating the trial implementation processes, required resources and management, scientific aspects, and participant acceptability and usage of the SPIN-SELF program. Methods: The SPIN-SELF feasibility trial will be conducted via the SPIN Cohort. The SPIN Cohort was developed as a framework for embedded pragmatic trials using the cohort multiple RCT design. In total, 40 English-speaking SPIN Cohort participants with low disease management self-efficacy (Self-Efficacy for Managing Chronic Disease Scale score ≤7), who have indicated interest in using a Web-based self-management program, will be randomized with a 3:2 ratio into the SPIN-SELF program or usual care for 3 months. Feasibility outcomes include trial implementation processes, required resources and management, scientific aspects, and patient acceptability and usage of the SPIN-SELF program. Results: Enrollment of the 40 participants occurred between July 5, 2019, and July 27, 2019. By November 25, 2019, data collection of trial outcomes was completed. Data analysis is underway, and results are expected to be published in 2020. Conclusions: The SPIN-SELF program is a self-h
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- 2020
14. Shortening patient-reported outcome measures through optimal test assembly: Application to the Social Appearance Anxiety Scale in the Scleroderma Patient-centered Intervention Network Cohort
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Harel, D., Mills, S.D., Kwakkenbos, L., Carrier, M.E., Nielsen, K., Portales, A., Bartlett, S.J., Malcarne, V.L., Thombs, B.D., Baron, M., Furst, D.E., Gottesman, K., Mayes, M.D., Mouthon, L., Nielson, W.R., Riggs, R., Sauve, M., Wigley, F., Assassi, S., Boutron, I., Maia, A.C., El-Baalbaki, G., Ells, C., Ende, C. van den, Fligelstone, K., Fortune, C., Frech, T., Godard, D., Hudson, M., Impens, A., Jang, Y., Johnson, S.R., Kennedy, A.T., Korner, A., Larche, M., Leite, C., Marra, C., Pope, J., Reyna, T.S.R., Schouffoer, A.A., Steele, R.J., Suarez-Almazor, M.E., Welling, J., Wong-Rieger, D., Agard, C., Albert, A., Andre, M., Arsenault, G., Benmostefa, N., Benzidia, I., Berthier, S., Bissonnette, L., Boire, G., Bruns, A., Carreira, P., Casadevall, M., Chaigne, B., Chung, L., Cohen, P., Dagenais, P., Denton, C., Domsic, R., Dubois, S., Dunne, J.V., Dunogue, B., Esquinca, A., Fare, R., Farge-Bancel, D., Fortin, P.R., Gill, A., Gordon, J., Granel-Rey, B., Grange, C., Gyger, G., Hachulla, E., Hatron, P.Y., Herrick, A.L., Hij, A., Hinchcliff, M., Ikic, A., Jones, N., Fernandes, A.J.D., Kafaja, S., Khalidi, N., Korman, B., Launay, D., Liang, P., London, J., Luna, D., Maillard, H., Manning, J., Martin, M., Martin, T., Masetto, A., Maurier, F., Mekinian, A., Melchor, S., Nikpour, M., Paule, R., Proudman, S., Regent, A., Riviere, S., Robinson, D., Rodriguez, E., Roux, S., Smets, P., Smith, D., Sobanski, V., Spiera, R., Steen, V., Stevens, W., Sutton, E., Terrier, B., Thorne, C., Varga, J., Wilcox, P., Wilson, M., Cumin, J., Fox, R.S., Gholizadeh, S., Jewett, L.R., Levis, B., Pepin, M.R., Turner, K.A., Lambert, M., and SPIN Investigators
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Adult ,Male ,medicine.medical_specialty ,systemic sclerosis ,Concurrent validity ,Anxiety ,Fear of negative evaluation ,Cohort Studies ,Experimental Psychopathology and Treatment ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Cronbach's alpha ,medicine ,Humans ,Patient Reported Outcome Measures ,optimal test assembly ,030212 general & internal medicine ,Aged ,Aged, 80 and over ,Scleroderma, Systemic ,business.industry ,Research ,short form ,Social anxiety ,Reproducibility of Results ,generalized partial credit model ,General Medicine ,Middle Aged ,stomatognathic diseases ,Cross-Sectional Studies ,Convergent validity ,patient reported outcome measure ,Physical Appearance, Body ,Physical therapy ,Female ,Patient-reported outcome ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Cohort study - Abstract
ObjectivesThe Social Appearance Anxiety Scale (SAAS) is a 16-item measure that assesses social anxiety in situations where appearance is evaluated. The objective was to use optimal test assembly (OTA) methods to develop and validate a short-form SAAS based on objective and reproducible criteria.DesignThis study was a cross-sectional analysis of baseline data from adults enrolled in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort.SettingAdults in the SPIN Cohort in the present study were enrolled at 28 centres in Canada, the USA and the UK.ParticipantsThe SAAS was administered to 926 adults with scleroderma.Primary and secondary measuresThe SAAS, Brief Fear of Negative Evaluation II (BFNE II), Brief Satisfaction with Appearance Scale (Brief-SWAP), Patient Health Questionnaire-8 (PHQ8) and Social Interaction Anxiety Scale-6 (SIAS-6) were collected, as well as demographic characteristics.ResultsOTA methods identified a maximally informative shortened version for each possible form length between 1 and 15 items. The final shortened version was selected based on prespecified criteria for reliability, concurrent validity and statistically equivalent convergent validity with the BFNE II scale. A five-item short version was selected (SAAS-5). The SAAS-5 had a Cronbach’s α of 0.95 and had high concurrent validity with the full-length form (r=0.97). The correlation of the SAAS-5 with the BFNE II was 0.66, which was statistically equivalent to that of the full-length form. Furthermore, the correlation of the SAAS-5 with the two subscales of the Brief-SWAP, and the SIAS-6, were statistically equivalent to that of the full-length form.ConclusionsOTA was an efficient method for shortening the full-length SAAS to create the SAAS-5.
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- 2019
15. The Scleroderma Patient-centered Intervention Network (SPIN): Engaging patients in rheumatology research
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Fedoruk, C., Kwakkenbos, L., Carrier, M.E., Rice, D.B., Turner, K.A., Cañedo-Ayala, M., Tao, L.X., Harb, S., Gholizadeh, S., Carboni-Jiménez, A., Aguila, K., Thombs, B.D., Fedoruk, C., Kwakkenbos, L., Carrier, M.E., Rice, D.B., Turner, K.A., Cañedo-Ayala, M., Tao, L.X., Harb, S., Gholizadeh, S., Carboni-Jiménez, A., Aguila, K., and Thombs, B.D.
- Abstract
Contains fulltext : 219626.pdf (Publisher’s version ) (Open Access)
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- 2019
16. Latent profile analysis-derived typologies of systemic sclerosis patients using body image indicators: A Scleroderma Patient-centered Intervention Network (SPIN) Cohort Study
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Gholizadeh, S., Kwakkenbos, L., Carrier, M.E., Mills, S.D., Fox, R.S., Jewett, L.R., Gottesman, K., Roesch, S.C., Thombs, B.D., Malcarne, V.L., Carboni-Jiménez, A., Gholizadeh, S., Kwakkenbos, L., Carrier, M.E., Mills, S.D., Fox, R.S., Jewett, L.R., Gottesman, K., Roesch, S.C., Thombs, B.D., Malcarne, V.L., and Carboni-Jiménez, A.
- Abstract
Contains fulltext : 219624.pdf (Publisher’s version ) (Open Access)
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- 2019
17. Addressing challenges to patient-centered care in a rare disease context: The Scleroderma Patient-centered Intervention Network (SPIN)
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Thombs, B.D., Kwakkenbos, L., Carrier, M.E., Rice, D.B., Fedoruk, C., Turner, K.A., Cañedo-Ayala, M., Carboni-Jiménez, A., Tao, L.X., Harb, S., Gholizadeh, S., Aguila, K., Sauvé, M., Thombs, B.D., Kwakkenbos, L., Carrier, M.E., Rice, D.B., Fedoruk, C., Turner, K.A., Cañedo-Ayala, M., Carboni-Jiménez, A., Tao, L.X., Harb, S., Gholizadeh, S., Aguila, K., and Sauvé, M.
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Contains fulltext : 219611.pdf (Publisher’s version ) (Open Access)
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- 2019
18. The effect of oral administration of eggplant hydroalcoholic extract on avoidance memory retrieval in streptozotocin-induced diabetic male rats
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Gholizadeh, S., saeid valipour chahardahcharic, and Sazegar, H.
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Medicine (General) ,R5-920 ,Streptozotocin ,Diabetes ,Rat ,Therapeutics. Pharmacology ,RM1-950 ,Avoidance memory ,Eggplant - Abstract
Introduction: Diabetes is caused by defects in insulin secretion or function. Diabetes causes structural and functional damage in the central and peripheral nervous system, including degeneration of the memory system. The present study is an attempt to determine the effect of eggplant extract on memory retrieval in diabetic rats. Methods: Mature male Wistar rats (200-250 g) are divided into five groups (n = 7): 1) healthy (control), 2) untreated diabetic, 3, 4 and 5) diabetic rats treated by the hydroalcoholic extract of eggplant (25, 50 and 100 mg/kg). Rats with streptozotocin (STZ) (60 mg/kg) became intraperitoneally diabetic. On the fifth day after receiving the STZ, the animals with blood glucose higher than 200 mg/dL, were considered diabetic. The control group only received saline and the treated diabetic group received eggplant extract orally for two weeks. The healthy group did not receive any medication or extract. Shuttle box was used to assess the spatial memory of the rats. Results: Eggplant extract in higher doses (50 and 100 mg/kg) significantly reduced blood glucose levels in diabetic rats (P < 0.001). The spatial memory in diabetic rats was weakened (P < 0.01). Eggplant extract at a dose of 50 mg/kg significantly improved the paramnesia in diabetic group (P < 0.05). Conclusion: STZ increased blood glucose, resulting in spatial memory deficits, And this has probably occurred through the production of free radicals in the brain tissue. It seems that, in addition to reducing blood glucose levels, eggplant, due to containing compounds with antioxidant properties, can reduce free radicals and thereby improve memory deficits caused by diabetes.
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- 2016
19. Examination of the association of sex and race/ethnicity with appearance concerns: A Scleroderma Patient-centered Intervention Network (SPIN) cohort study
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Jewett, L. R., Kwakkenbos, L., Carrier, M. -E, Malcarne, V. L., Susan Bartlett, Furst, D. E., Gottesman, K., Mayes, M. D., Assassi, S., Harcourt, D., Williamson, H., Johnson, S. R., Korner, A., Steen, V., Fox, R. S., Gholizadeh, S., Mills, S. D., Molnar, J. C., Rice, D. B., and Thombs, B. D.
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Experimental Psychopathology and Treatment - Abstract
Item does not contain fulltext OBJECTIVES: Appearance concerns are common in systemic sclerosis (SSc) and have been linked to younger age and more severe disease. No study has examined their association with sex or race/ethnicity. METHODS: SSc patients were sampled from the Scleroderma Patient-centered Intervention Network Cohort. Presence of appearance concerns was assessed with a single item, and medical and sociodemographic information were collected. RESULTS: Of 644 patients, appearance concerns were present in 72%, including 421 of 565 women (75%), 42 of 79 men (53%), 392 of 550 patients who identified as White (71%), 35 of 41 who identified as Black (85%), and 36 of 53 who identified as another race/ethnicity (68%). In multivariate analysis, women had significantly greater odds of reporting appearance concerns than men (odds ratio (OR)=2.97, 95% confidence interval (CI)=1.78-4.95, p
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- 2016
20. Validation of the Brief Fear of Negative Evaluation Scale-II in patients with systemic sclerosis: A Scleroderma Patient-centered Intervention Network Cohort study
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Fox, R.S., Kwakkenbos, L., Carrier, M.E., Mills, S.D., Gholizadeh, S., Jewett, L.R., Roesch, S.C., Merz, E.L., Assassi, S., Furst, D.E., Gottesman, K., Mayes, M.D., Thombs, B.D., and Malcarne, V.L.
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Experimental Psychopathology and Treatment - Abstract
Item does not contain fulltext Objective: Fear of negative evaluation is a common concern among individuals with visible differences but has received limited attention in systemic sclerosis (SSc), which can involve substantial changes to appearance. The Brief Fear of Negative Evaluation Scale (BFNE) was specifically designed to evaluate fear of negative evaluation. There are currently three versions of the BFNE with strong demonstrated measurement properties: two eight-item versions (BFNE-S, BFNE-8) and one 12-item version (BFNE-II). The present study evaluated these versions in SSc, and identified the most appropriate version for use among SSc patients. Methods: Participants were 1010 patients with SSc enrolled in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort. Multiple group confirmatory factor analysis, Cronbach's alpha, and Pearson product-moment correlations were used to evaluate structural validity, internal consistency reliability, and convergent and divergent validity, respectively. Results: Confirmatory factor analysis demonstrated that one-factor models fit acceptably well for the 12-item BFNE-II, the eight-item BFNE-S, and the eight-item BFNE-8. All Cronbach's alphas were excellent (BFNE-II: 0.98; BFNE-S: 0.97; BFNE-8: 0.96), and all versions had comparable associations with measures of social anxiety, body-related attitudes, depression, age, and education. Conclusion: Psychometric support was found for all three versions of the BFNE, though the longer 12-item BFNE-II did not improve measurement compared to the shorter eight-item versions. Of these two, the BFNE-S has been more widely studied with strong validity data in a greater number of populations. Therefore, the BFNE-S is recommended to assess fear of negative evaluation among patients with SSc. 7 p.
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- 2018
21. Body image mediates the impact of pain on depressive symptoms in patients with systemic lupus erythematosus
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Gholizadeh, S, primary, Azizoddin, D R, additional, Mills, S D, additional, Zamora, G, additional, Potemra, H M K, additional, Hirz, A E, additional, Wallace, D J, additional, Weisman, M H, additional, and Nicassio, P M, additional
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- 2019
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22. Evaluation of shear bond strength of zirconia to composite resin using different adhesive systems
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Zakavi, F, primary, Mombeini, M, additional, Dibazar, S, additional, and Gholizadeh, S, additional
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- 2019
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23. Validation of the Social Appearance Anxiety Scale in patients with systemic sclerosis: A Scleroderma Patient-centered Intervention Network Cohort study
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Mills, S.D., Kwakkenbos, L., Carrier, M.E., Gholizadeh, S., Fox, R.S., Jewett, L.R., Gottesman, K., Roesch, S.C., Thombs, B.D., Malcarne, V.L., Mills, S.D., Kwakkenbos, L., Carrier, M.E., Gholizadeh, S., Fox, R.S., Jewett, L.R., Gottesman, K., Roesch, S.C., Thombs, B.D., and Malcarne, V.L.
- Abstract
Contains fulltext : 195880.pdf (publisher's version ) (Closed access), Objective: Systemic sclerosis (SSc) is an autoimmune disease that can cause disfiguring changes in appearance. This study examined the structural validity, internal consistency reliability, convergent validity, and measurement equivalence of the Social Appearance Anxiety Scale (SAAS) across SSc disease subtypes. Methods: Patients enrolled in the Scleroderma Patient-centered Intervention Network Cohort completed the SAAS and measures of appearance-related concerns and psychological distress. Confirmatory factor analysis (CFA) was used to examine the structural validity of the SAAS. Multiple-group CFA was used to determine if SAAS scores can be compared across patients with limited and diffuse disease subtypes. Cronbach's alpha was used to examine internal consistency reliability. Correlations of SAAS scores with measures of body image dissatisfaction, fear of negative evaluation, social anxiety, and depression were used to examine convergent validity. SAAS scores were hypothesized to be positively associated with all convergent validity measures, with correlations significant and moderate to large in size. Results: A total of 938 patients with SSc were included. CFA supported a one-factor structure (CFI: .92; SRMR: .04; RMSEA: .08), and multiple-group CFA indicated that the scalar invariance model best fit the data. Internal consistency reliability was good in the total sample (α = .96) and in disease subgroups. Overall, evidence of convergent validity was found with measures of body image dissatisfaction, fear of negative evaluation, social anxiety, and depression. Conclusion: The SAAS can be reliably and validly used to assess fear of appearance evaluation in patients with SSc, and SAAS scores can be meaningfully compared across disease subtypes.
- Published
- 2018
24. Reliability and validity of three versions of the Brief Fear of Negative Evaluation Scale in patients with systemic sclerosis: A Scleroderma Patient-Centered Intervention Network Cohort study
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Fox, R.S., Kwakkenbos, L., Carrier, M.E., Mills, S.D., Gholizadeh, S., Jewett, L.R., Roesch, S.C., Merz, E.L., Assassi, S., Furst, D.E., Gottesman, K., Mayes, M.D., Thombs, B.D., Malcarne, V.L., Fox, R.S., Kwakkenbos, L., Carrier, M.E., Mills, S.D., Gholizadeh, S., Jewett, L.R., Roesch, S.C., Merz, E.L., Assassi, S., Furst, D.E., Gottesman, K., Mayes, M.D., Thombs, B.D., and Malcarne, V.L.
- Abstract
Contains fulltext : 197554.pdf (publisher's version ) (Closed access), Objective: Fear of negative evaluation is a common concern among individuals with visible differences but has received limited attention in systemic sclerosis (SSc), which can involve substantial changes to appearance. The Brief Fear of Negative Evaluation Scale (BFNE) was specifically designed to evaluate fear of negative evaluation. There are currently 3 versions of the BFNE with strong demonstrated measurement properties: two 8-item versions (BFNE-S, BFNE-8) and one 12-item version (BFNE-II). The present study evaluated these versions in SSc, and identified the most appropriate version for use among SSc patients. Methods: Participants were 1,010 patients with SSc enrolled in the Scleroderma Patient-Centered Intervention Network cohort. Multiple group confirmatory factor analysis, Cronbach's alpha, and Pearson's product-moment correlations were used to evaluate structural validity, internal consistency reliability, and convergent and divergent validity, respectively. Results: Confirmatory factor analysis demonstrated that 1-factor models fit acceptably well for the 12-item BFNE-II, the 8-item BFNE-S, and the 8-item BFNE-8. Additionally, all Cronbach's alphas demonstrated excellent internal consistency reliability (BFNE-II = 0.98, BFNE-S = 0.97, BFNE-8 = 0.96), and all versions had comparable associations with measures of social anxiety, body-related attitudes, depression, age, and education. Conclusion: Psychometric support was found for all 3 versions of the BFNE, although the longer 12-item BFNE-II did not improve measurement compared to the shorter 8-item versions (BFNE-S and BFNE-8). Of these 2, the BFNE-S has been more widely studied, with strong validity data in a greater number of populations. Therefore, the BFNE-S is recommended to assess fear of negative evaluation among patients with SSc.
- Published
- 2018
25. Validation of the Social Interaction Anxiety Scale in scleroderma: A Scleroderma Patient-centered Intervention Network cohort study
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Gholizadeh, S., Kwakkenbos, L., Carrier, M.E., Mills, S.D., Fox, R.S., Jewett, L.R., Gottesman, K., Roesch, S.C., Thombs, B.D., Malcarne, V.L., Gholizadeh, S., Kwakkenbos, L., Carrier, M.E., Mills, S.D., Fox, R.S., Jewett, L.R., Gottesman, K., Roesch, S.C., Thombs, B.D., and Malcarne, V.L.
- Abstract
Contains fulltext : 190216.pdf (publisher's version ) (Closed access), Introduction: Individuals with visible differences due to medical conditions, such as systemic sclerosis (SSc; scleroderma), have reported difficulty navigating social situations because of issues such as staring, invasive questions, and rude comments. Fears or anxiety linked to situations in which a person interacts with others is known as social interaction anxiety. However, there exists no validated measurement tool to examine social interaction anxiety in rheumatologic conditions. Methods: The present study examines the reliability (internal consistency) and validity (structural and convergent) of the Social Interaction Anxiety Scale-6 (SIAS-6) in a sample of 802 individuals with SSc, and compares these psychometric properties across limited and diffuse subtypes of the disease. Multi-group confirmatory factor analysis was used to examine the factor structure of the SIAS-6 in patients with both limited and diffuse SSc. Results: A one-factor structure was found to fit well for individuals with SSc with both limited and diffuse disease. The measure demonstrated strong internal consistency reliability and convergent validity with relevant measures in expected magnitudes and directions. Conclusions: The SIAS-6 is a psychometrically robust measure that can confidently be used in SSc populations to examine social interaction anxiety. Moreover, scores can meaningfully be compared between patients with limited and diffuse disease.
- Published
- 2018
26. Factor structure and convergent validity of the Derriford Appearance Scale-24 using standard scoring versus treating 'not applicable' responses as missing data: A Scleroderma Patient-centered Intervention Network (SPIN) cohort study
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Merz, E.L., Kwakkenbos, L., Carrier, M.E., Gholizadeh, S., Mills, S.D., Fox, R.S., Jewett, L.R., Williamson, H., Harcourt, D., Assassi, S., Furst, D.E., Gottesman, K., Mayes, M.D., Moss, T.P., Thombs, B.D., Malcarne, V.L., Merz, E.L., Kwakkenbos, L., Carrier, M.E., Gholizadeh, S., Mills, S.D., Fox, R.S., Jewett, L.R., Williamson, H., Harcourt, D., Assassi, S., Furst, D.E., Gottesman, K., Mayes, M.D., Moss, T.P., Thombs, B.D., and Malcarne, V.L.
- Abstract
Contains fulltext : 187211.pdf (publisher's version ) (Open Access), Objective: Valid measures of appearance concern are needed in systemic sclerosis (SSc), a rare, disfiguring autoimmune disease. The Derriford Appearance Scale-24 (DAS-24) assesses appearance-related distress related to visible differences. There is uncertainty regarding its factor structure, possibly due to its scoring method. Design: Cross-sectional survey. Setting: Participants with SSc were recruited from 27 centres in Canada, the USA and the UK. Participants who self-identified as having visible differences were recruited from community and clinical settings in the UK. Participants: Two samples were analysed (n=950 participants with SSc; n=1265 participants with visible differences). Primary and secondary outcome measures: The DAS-24 factor structure was evaluated using two scoring methods. Convergent validity was evaluated with measures of social interaction anxiety, depression, fear of negative evaluation, social discomfort and dissatisfaction with appearance. Results: When items marked by respondents as 'not applicable' were scored as 0, per standard DAS-24 scoring, a one-factor model fit poorly; when treated as missing data, the one-factor model fit well. Convergent validity analyses revealed strong correlations that were similar across scoring methods. Conclusions: Treating 'not applicable' responses as missing improved the measurement model, but did not substantively influence practical inferences that can be drawn from DAS-24 scores. Indications of item redundancy and poorly performing items suggest that the DAS-24 could be improved and potentially shortened.
- Published
- 2018
27. PSY205 - BODY IMAGE IN SLE AND THE RELATIONSHIP BETWEEN DISEASE ACTIVITY AND PSYCHOSOCIAL CONCERNS
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Azizoddin, D., primary, Gholizadeh, S., additional, Mills, S.D., additional, Potemra, H.M., additional, Zamora Racaza, G., additional, Wallace, D., additional, Weisman, M., additional, and Nicassio, P., additional
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- 2018
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28. Psychometric validation of the Arthritis Helplessness Index in systemic lupus erythematosus
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Gholizadeh, S, primary, Azizoddin, D R, additional, Mills, S D, additional, Zamora-Racaza, G, additional, Potemra, H M K, additional, Wallace, D J, additional, Weisman, M H, additional, and Nicassio, P M, additional
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- 2018
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29. Extended Creutz ladder with spin-orbit coupling: A one-dimensional analog of the Kane-Mele model
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Gholizadeh, S., primary, Yahyavi, M., additional, and Hetényi, B., additional
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- 2018
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30. Abstract P2-03-07: Digital image analysis of Ki67 in hot spots is superior to alternative proliferation associated markers in breast cancer
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Robertson, S, primary, Stålhammar, G, additional, Wedlund, L, additional, Gholizadeh, S, additional, Lippert, M, additional, Rantaleinen, M, additional, Bergh, J, additional, and Hartman, J, additional
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- 2018
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31. The mediational role of helplessness in psychological outcomes in systemic lupus erythematosus
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Mills, S D, primary, Azizoddin, D, additional, Gholizadeh, S, additional, Racaza, G Z, additional, and Nicassio, P M, additional
- Published
- 2018
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32. Validation of the Body Concealment Scale for Scleroderma (BCSS): Replication in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort
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Jewett, L.R., Kwakkenbos, L., Carrier, M.E., Malcarne, V.L., Harcourt, D., Rumsey, N., Mayes, M.D., Assassi, S., Körner, A., Fox, R.S., Gholizadeh, S., Mills, S.D., Fortune, C., Thombs, B.D., Jewett, L.R., Kwakkenbos, L., Carrier, M.E., Malcarne, V.L., Harcourt, D., Rumsey, N., Mayes, M.D., Assassi, S., Körner, A., Fox, R.S., Gholizadeh, S., Mills, S.D., Fortune, C., and Thombs, B.D.
- Abstract
Item does not contain fulltext, Body concealment is an important component of appearance distress for individuals with disfiguring conditions, including scleroderma. The objective was to replicate the validation study of the Body Concealment Scale for Scleroderma (BCSS) among 897 scleroderma patients. The factor structure of the BCSS was evaluated using confirmatory factor analysis and the Multiple-Indicator Multiple-Cause model examined differential item functioning of SWAP items for sex and age. Internal consistency reliability was assessed via Cronbach's alpha. Construct validity was assessed by comparing the BCSS with a measure of body image distress and measures of mental health and pain intensity. Results replicated the original validation study, where a bifactor model provided the best fit. The BCSS demonstrated strong internal consistency reliability and construct validity. Findings further support the BCSS as a valid measure of body concealment in scleroderma and provide new evidence that scores can be compared and combined across sexes and ages.
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- 2017
33. Acoustic emission analysis for characterisation of damage mechanisms in glass fiber reinforced polyester composite
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Gholizadeh, S., primary, Leman, Z., additional, Baharudin, B. T. H. T., additional, and Inayatullah, O., additional
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- 2016
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34. Examination of the association of sex and race/ethnicity with appearance concerns: A Scleroderma Patient-centered Intervention Network (SPIN) cohort study
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Jewett, L.R., Kwakkenbos, L., Carrier, M.E., Malcarne, V.L., Bartlett, S.J., Furst, D.E., Gottesman, K., Mayes, M.D., Assassi, S., Harcourt, D., Williamson, H., Johnson, S.R., Körner, A., Steen, V., Fox, R.S., Gholizadeh, S., Mills, S.D., Molnar, J.C., Rice, D.B., Thombs, B.D., Jewett, L.R., Kwakkenbos, L., Carrier, M.E., Malcarne, V.L., Bartlett, S.J., Furst, D.E., Gottesman, K., Mayes, M.D., Assassi, S., Harcourt, D., Williamson, H., Johnson, S.R., Körner, A., Steen, V., Fox, R.S., Gholizadeh, S., Mills, S.D., Molnar, J.C., Rice, D.B., and Thombs, B.D.
- Abstract
Item does not contain fulltext, OBJECTIVES: Appearance concerns are common in systemic sclerosis (SSc) and have been linked to younger age and more severe disease. No study has examined their association with sex or race/ethnicity. METHODS: SSc patients were sampled from the Scleroderma Patient-centered Intervention Network Cohort. Presence of appearance concerns was assessed with a single item, and medical and sociodemographic information were collected. RESULTS: Of 644 patients, appearance concerns were present in 72%, including 421 of 565 women (75%), 42 of 79 men (53%), 392 of 550 patients who identified as White (71%), 35 of 41 who identified as Black (85%), and 36 of 53 who identified as another race/ethnicity (68%). In multivariate analysis, women had significantly greater odds of reporting appearance concerns than men (odds ratio (OR)=2.97, 95% confidence interval (CI)=1.78-4.95, p<.001). Black patients had significantly greater odds of appearance concerns than White patients in unadjusted (OR=2.64, 95% CI=1.01-6.34, p=.030), but not multivariate analysis (OR=1.76, 95% CI=0.67-4.60, p=.250). Compared to a general population sample, appearance concerns were substantially more common in SSc, particularly for men across all age groups and for younger women. The most commonly reported features of concern were related to the face and head, followed by the hands and fingers; this did not differ by sex or race/ethnicity. CONCLUSIONS: Appearance concerns were common in SSc. Women were substantially more likely than men to have appearance concerns. Although non-significant in multivariate analysis, Black patients were more likely to have concerns than White patients, likely due to more severe changes in appearance.
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- 2016
35. Psychometric properties of the Social Appearance Anxiety Scale in patients with limited and diffuse systemic sclerosis: Analysis from the Scleroderma Patient-Centered Intervention Network Cohort
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Mills, S.D., Gholizadeh, S., Fox, R.S., Jewett, L.R., Carrier, M.E., Kwakkenbos, L., Gottesman, K., Roesch, S.C., Thombs, B.D., Malcarne, V.L., Mills, S.D., Gholizadeh, S., Fox, R.S., Jewett, L.R., Carrier, M.E., Kwakkenbos, L., Gottesman, K., Roesch, S.C., Thombs, B.D., and Malcarne, V.L.
- Abstract
Item does not contain fulltext
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- 2015
36. Psychosocial aspects of scleroderma
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Kwakkenbos, L., Delisle, V.C., Fox, R.S., Gholizadeh, S., Jewett, L.R., Levis, B., Milette, K., Mills, S.D., Malcarne, V.L., Thombs, B.D., Kwakkenbos, L., Delisle, V.C., Fox, R.S., Gholizadeh, S., Jewett, L.R., Levis, B., Milette, K., Mills, S.D., Malcarne, V.L., and Thombs, B.D.
- Abstract
Item does not contain fulltext, Patients with systemic sclerosis (SSc; also called scleroderma) have to cope with not only the physical impacts of the disease but also the emotional and social consequences of living with the condition. Because there is no cure for SSc, improving quality of life is a primary focus of treatment and an important clinical challenge. This article summarizes significant problems faced by patients with SSc, including depression, anxiety, fatigue, sleep disruption, pain, pruritus, body image dissatisfaction, and sexual dysfunction, and describes options to help patients cope with the consequences of the disease.
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- 2015
37. Acoustic emission analysis for characterisation of damage mechanisms in glass fiber reinforced polyester composite.
- Author
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Gholizadeh, S., Leman, Z., Baharudin, B. T. H. T., and Inayatullah, O.
- Subjects
- *
ACOUSTIC emission , *FRACTURE mechanics , *GLASS fibers , *FIBER-reinforced plastics , *POLYESTERS , *POLYMERIC composites - Abstract
This study assesses the progression of damage occurring on glass fiber reinforced polyester composite specimens using acoustic emission (AE) parameters. Its aims are to improve understanding of the particular characteristics of AE signals; and also to determine the relationship between AE signals and the failure of the material. Time and frequency domain trends were analysed at four different applied loads (60.97, 67.75, 74.52 and 81.30 MPa) representing 45–60% of the ultimate tensile strength of material. The relevant AE parameters were analysed both in the early stages of the test and as the material neared the fracture zone. The results showed a high degree of correlation between the root mean square and number of hits AE values and the number of cycles to failure, of 92.99 and 92.19%, respectively. This correlation, as well as AE basic parameters, suggests that AE can be a valuable tool to predict the fatigue life and detect the onset of damage in such composite materials. [ABSTRACT FROM AUTHOR]
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- 2018
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38. A review of the application of acoustic emission technique in engineering
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Gholizadeh, S., primary, Leman, Z., additional, and Baharudin, B.T.H.T., additional
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- 2015
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39. The Anopheles stephensi odorant binding protein 1 (AsteObp1) gene: A new molecular marker for biological forms diagnosis
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Gholizadeh, S., primary, Firooziyan, S., additional, Ladonni, H., additional, Hajipirloo, H. Mohammadzadeh, additional, Djadid, N. Dinparast, additional, Hosseini, A., additional, and Raz, A., additional
- Published
- 2015
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40. Double layer packaging based on active black chickpea protein isolate electrospun nanofibers and intelligent salep film containing black chickpea peel anthocyanins for seafood products.
- Author
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Amjadi S, Almasi H, Gholizadeh S, and Hamishehkar H
- Subjects
- Plant Proteins chemistry, beta-Cyclodextrins chemistry, Nanofibers chemistry, Food Packaging methods, Cicer chemistry, Anthocyanins chemistry, Seafood analysis
- Abstract
In this study, a double-layer active and intelligent packaging system was developed based on two main natural macromolecules i.e. protein and carbohydrate with green perspective. Firstly, the salep-based films containing different concentrations (0-8 % w/w) of the inclusion complex of β-cyclodextrin/black chickpea anthocyanins (βCD/BCPA) were produced. The salep film containing 8 % of βCD/BCPA complex was specified as the optimized film sample based on its performance as a color indicator. The electrospinning of black chickpea protein isolate nanofibers (BCPI NFs) containing citral nanoliposomes (NLPs) was done on the optimized salep film. The cross-sectional field emission scanning electron microscopy approved the creation of double-layer structure of the developed film. The study of chemical and crystalline structure, as well as the thermal properties of the film exhibited the physical attachment of BCPI electrospun NFs on salep film. The effectiveness of the developed system was studied in detection of spoilage and increasing the shelf life of seafood products, including shrimp and fish fillet. The performance of the intelligent layer in detection of freshness/spoilage was acceptable for both seafood products. In addition, the active layer of the film controlled the changes of pH, total volatile basic nitrogen, oxidation, and microbial load in samples during storage time., Competing Interests: Declaration of competing interest The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (Copyright © 2024 Elsevier B.V. All rights reserved.)
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- 2024
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41. Predicting overall survival in anaplastic thyroid cancer using machine learning approaches.
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Barfejani AH, Rostami M, Rahimi M, Far HS, Gholizadeh S, Behjat M, and Tarokhian A
- Abstract
Purpose: Anaplastic thyroid carcinoma (ATC) is a highly aggressive and lethal thyroid cancer subtype with a poor prognosis. Recent advancements in machine learning (ML) have the potential to improve survival predictions. This study aimed to develop and validate ML models using the SEER database to predict 3-month, 6-month, and 12-month (overall survival) OS in ATC patients., Methods: Clinical and demographic data for patients with ATC from the SEER database (2004-2015) were utilized. Five ML algorithms-AdaBoost, support vector machines, gradient boosting classifiers, random forests, and naive Bayes-were evaluated. The data were split into training and testing sets (7:3 ratio), and the models were tuned using fivefold cross-validation. Model performance was assessed using the concordance index (C-index) and Brier score, with 95% confidence intervals reported., Results: The gradient boosting model achieved the greatest performance for 3-month survival (C-index: 0.8197, 95% CI 0.7682-0.8689; Brier score: 0.1802), and the AdaBoost model achieved the greatest performance in 6-month survival (C-index: 0.8473, 95% CI 0.7979-0.8933; Brier score: 0.1775). The SVC model showed superior performance for 12-month survival (C-index: 0.8347, 95% CI 0.7866-0.8816; Brier score: 0.1476). Using SHAP with a gradient boosting model, the top five features affecting 6-month OS were identified: surgery, the presence of stage IVC, radiation, chemotherapy, and tumor size. Treatment improved survival, while higher stages reduced survival, with smaller tumors generally linked to better outcomes., Conclusion: ML algorithms can accurately predict short-term survival in ATC patients. These models can potentially guide clinical decision-making and individualized treatment strategies., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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42. Socioeconomic status, reserve capacity, and depressive symptoms predict pain in Rheumatoid Arthritis: an examination of the reserve capacity model.
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Azizoddin DR, Olmstead R, Anderson KA, Hirz AE, Irwin MR, Gholizadeh S, Weisman M, Ishimori M, Wallace D, and Nicassio P
- Abstract
Background: Guided by the reserve capacity model, we evaluated the unique relationships between socioeconomic status (SES), reserve capacity (helplessness, self-efficacy, social support), and negative emotions on pain in patients with Rheumatoid Arthritis (RA)., Methods: The secondary analysis used baseline, cross-sectional data from 106 adults in a clinical trial comparing behavioral treatments for RA. Patients were eligible if they were ≥ 18 years old, met the ACR criteria for RA (determined by study rheumatologist), had stable disease and drug regimens for 3 months, and did not have a significant comorbid condition. Structural equation modeling evaluated the direct effects of SES, reserve capacity (helplessness- Arthritis Helplessness Index, self-efficacy -Personal Mastery Scale, social support- Social Provisions Scale) and negative emotions (stress and depressive symptoms- Perceived Stress Scale and Hamilton Depression Rating Scale) on pain (Rapid Assessment of Disease Activity in Rheumatology-RADAR & visual analog scale-VAS), and the indirect effects of SES as mediated by reserve capacity and negative emotions. The SEM model was evaluated using multiple fit criteria: χ
2 goodness-of-fit statistic, the comparative fit index (CFI), the standardized root mean square residual (SRMR), and the root mean square error of approximation (RMSEA)., Results: Participants were mostly female (85%), 55.45 years old on average, self-identified as white (61%), Hispanic (16%), black (13%), and other (10%), and had RA for an average of 10.63 years. Results showed that low SES contributed to worse pain, through lower reserve capacity and higher negative emotions. Mediational analyses showed that reserve capacity and negative emotions partially mediated the effect of SES on pain. The final model explained 39% of the variance in pain., Conclusions: The findings indicate that lower SES was related to worse clinical pain outcomes and negative emotions and reserve capacity (helplessness, social support, and self-efficacy) mediated the effect of SES on pain. A primary limitation is the small sample size; future studies should evaluate this model further in larger, longitudinal approaches. Interventions that target negative emotions in patients with low SES may facilitate better pain control with RA., Trial Registration: clinicaltrials.gov NCT00072657 01/02/2004 20/03/2009., (© 2024. The Author(s).)- Published
- 2024
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43. Proteomic analysis during seed development provides insight into the early establishment of seed dormancy in Xanthium strumarium.
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Nemati I, Hamzelou S, Gholizadeh S, Kamath KS, Haynes PA, Sedghi M, Afshari RT, and Salekdeh GH
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- Proteome metabolism, Germination physiology, Gene Expression Regulation, Plant, Seeds metabolism, Seeds growth & development, Seeds genetics, Xanthium metabolism, Xanthium genetics, Xanthium growth & development, Plant Dormancy physiology, Proteomics methods, Plant Proteins metabolism, Plant Proteins genetics
- Abstract
This experiment was carried out to provide a comprehensive insight into the protein activities involved in dormancy establishment in seeds of common cocklebur (Xanthium strumarium), an annual plant with two dimorphic seeds contained in one casing known as a burr. These consist of a smaller dormant seed and a larger non-dormant seed. The proteome profile was compared between developing dormant and non-dormant seeds of Xanthium strumarium at five consecutive stages including three, 10, 20, 30, and 45 days after burr emergence (stages 1 to 5). We identified 6524 proteins in total, and approximately 3.6% of these were differentially abundant proteins (DAPs) between the two seed types. Both seed types showed fundamental changes in developmental programs during the examined stages. More than 38% of all DAPs were observed at the first stage, supporting the importance of the early developmental stage in seed fate determination. The detected DAPs at stage 1 were mainly associated with the cell division phase, which showed a delay in the dormant seeds. Over-representation of proteins responsible for cell wall biosynthesis, cytokinesis, and seed development were detected for non-dormant seeds at the first stage, while dormancy-associated proteins showed less abundance. Stage 3 was the critical stage for switching processes toward seed maturation and abscisic acid (ABA) signaling. Interestingly, higher abundance proteins in the mature non-dormant seed were mainly involved in the facilitation of seed germination. Taken together, the temporal pattern of the accumulated proteins in developing dormant seeds demonstrated a delay in the initiation of active cell division, enriched response to ABA, and defects in seed maturation. Moreover, stored proteins in the mature dormant seed delay germination but not dormancy induction. Finally, our results suggest that dormancy may be established at a stage of seed development earlier than previously thought., (© 2024 Scandinavian Plant Physiology Society.)
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- 2024
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44. Thy-DAMP: deep artificial neural network model for prediction of thyroid cancer mortality.
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Barfejani AH, Rahimi M, Safdari H, Gholizadeh S, Borzooei S, Roshanaei G, Golparian M, and Tarokhian A
- Abstract
Purpose: Despite the rising incidence of differentiated thyroid cancer (DTC), mortality rates have remained relatively low yet crucial for effective patient management. This study aims to develop a deep neural network capable of predicting mortality in patients with differentiated thyroid cancer., Methods: Leveraging data from the Surveillance, Epidemiology, and End Results (SEER) database, we developed Thy-DAMP (Deep Artificial Neural Network Model for Prediction of Thyroid Cancer) to forecast mortality in DTC patients. The dataset comprised demographic, histologic, and staging information. Following data normalization and feature encoding, the dataset was partitioned into training, testing, and validation subsets, with model hyperparameters fine-tuned via cross-validation., Results: Among the 63,513 patients, the mean age was 48.22 years (SD = 14.8), with 77.32% being female. Papillary carcinoma emerged as the predominant subtype, representing 62.94% of cases. The majority presented with stage I disease (73.96%). Thy-DAMP demonstrated acceptable performance metrics on both the test and validation sets. Sensitivity was 83.24% (95% CI 76.95-88.40%), specificity was 93.53% (95% CI 93.01-94.02%), and accuracy stood at 93.33% (95% CI 92.82-93.83%). The model exhibited a positive predictive value of 19.76% (95% CI 18.20-21.42%) and a negative predictive value of 99.66% (95% CI 99.53-99.75%). Additionally, Thy-DAMP demonstrated a positive likelihood ratio of 12.86 (95% CI 11.62-14.23), a negative likelihood ratio of 0.18 (95% CI 0.13-0.25), and an area under the receiver operating characteristic curve (AUROC) of 0.95. The model was externally validated on a separate dataset with nearly identical performance., Conclusion: Thy-DAMP showcases considerable promise in accurately predicting mortality in DTC patients, leveraging limited set of patient data., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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45. Discovery of a Peptoid-Based Nanoparticle Platform for Therapeutic mRNA Delivery via Diverse Library Clustering and Structural Parametrization.
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Webster ER, Peck NE, Echeverri JD, Gholizadeh S, Tang WL, Woo R, Sharma A, Liu W, Rae CS, Sallets A, Adusumilli G, Gunasekaran K, Haabeth OAW, Leong M, Zuckermann RN, Deutsch S, and McKinlay CJ
- Subjects
- Animals, Mice, Humans, Respiratory Syncytial Viruses, Lipids chemistry, Peptoids chemistry, Nanoparticles chemistry, RNA, Messenger genetics, RNA, Messenger metabolism
- Abstract
Nanoparticle-mediated mRNA delivery has emerged as a promising therapeutic modality, but its growth is still limited by the discovery and optimization of effective and well-tolerated delivery strategies. Lipid nanoparticles containing charged or ionizable lipids are an emerging standard for in vivo mRNA delivery, so creating facile, tunable strategies to synthesize these key lipid-like molecules is essential to advance the field. Here, we generate a library of N-substituted glycine oligomers, peptoids, and undertake a multistage down-selection process to identify lead candidate peptoids as the ionizable component in our Nutshell nanoparticle platform. First, we identify a promising peptoid structural motif by clustering a library of >200 molecules based on predicted physical properties and evaluate members of each cluster for reporter gene expression in vivo. Then, the lead peptoid motif is optimized using design of experiments methodology to explore variations on the charged and lipophilic portions of the peptoid, facilitating the discovery of trends between structural elements and nanoparticle properties. We further demonstrate that peptoid-based Nutshells leads to expression of therapeutically relevant levels of an anti-respiratory syncytial virus antibody in mice with minimal tolerability concerns or induced immune responses compared to benchmark ionizable lipid, DLin-MC3-DMA. Through this work, we present peptoid-based nanoparticles as a tunable delivery platform that can be optimized toward a range of therapeutic programs.
- Published
- 2024
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46. Harnessing root-soil-microbiota interactions for drought-resilient cereals.
- Author
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Gholizadeh S, Nemati I, Vestergård M, Barnes CJ, Kudjordjie EN, and Nicolaisen M
- Subjects
- Edible Grain, Droughts, Soil Microbiology, Plant Roots, Soil, Microbiota
- Abstract
Cereal plants form complex networks with their associated microbiome in the soil environment. A complex system including variations of numerous parameters of soil properties and host traits shapes the dynamics of cereal microbiota under drought. These multifaceted interactions can greatly affect carbon and nutrient cycling in soil and offer the potential to increase plant growth and fitness under drought conditions. Despite growing recognition of the importance of plant microbiota to agroecosystem functioning, harnessing the cereal root microbiota remains a significant challenge due to interacting and synergistic effects between root traits, soil properties, agricultural practices, and drought-related features. A better mechanistic understanding of root-soil-microbiota associations could lead to the development of novel strategies to improve cereal production under drought. In this review, we discuss the root-soil-microbiota interactions for improving the soil environment and host fitness under drought and suggest a roadmap for harnessing the benefits of these interactions for drought-resilient cereals. These methods include conservative trait-based approaches for the selection and breeding of plant genetic resources and manipulation of the soil environments., Competing Interests: Conflict of interest The authors declare no conflict of interest., (Copyright © 2024 The Authors. Published by Elsevier GmbH.. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
47. Development and characterization of active packaging system based on zein nanofibers mat incorporated with geraniol-loaded nanoliposomes.
- Author
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Gholizadeh S, Almasi H, Amjadi S, Moradi M, Ghadiri Alamdari N, Salmasi S, and Divsalar E
- Abstract
In recent years, development of biopolymeric nanofibers as an active biodegradable packaging system has attracted specific attention. The objective of this research was to develop zein-based electrospun nanofibers (NFs) incorporated with geraniol-loaded nanoliposomes (G-loaded NLPs). Geraniol was encapsulated into NLPs with an efficiency of 79.23%. The particle size and zeta potential of G-loaded NLPs were 121.50 nm and -38.30 mV, respectively. The successful loading of geraniol in the NLPs was approved by Fourier transform infrared (FT-IR) spectroscopy. The liposomal vesicles showed spherical shapes. G-loaded NLPs were added in the zein-based electrospun NFs at three different concentrations (0.25, 0.5, and 1%w/v). All NFs samples exhibited fibrillar structure. The increase of NLPs concentration enhanced the thermal stability of the NFs. However, the crystalline structure of zein NFs did not change by the addition of G-loaded NLPs. The highest surface hydrophobicity was related to the NFs containing 1% G-loaded NLPs. The mechanical parameters of NFs depend on the concentration of NLPs. The NFs incorporated with G-loaded NLPs showed inhibition activity against four foodborne pathogenic bacteria ( Staphylococcus aureus , Listeria monocytogenes , Escherichia coli , and Salmonella typhimurium ) with an inhibition zone of 4.5-22 mm. Moreover, the α-diphenyl-β-picrylhydrazyl (DPPH) scavenging activity of NFs samples was located at the range of 20%-48%. These findings represent the Efficiency of the G-loaded NLPs for use as bioactive compound in the zein-based NFs as an active packaging material., Competing Interests: The authors declare no competing interests., (© 2024 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.)
- Published
- 2024
- Full Text
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48. Effects of Two Remineralizing Agents in Combination with Er:YAG and CO 2 Laser Irradiation on Microhardness of Demineralized Enamel: A Preliminary In Vitro Study.
- Author
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Mapar M, Gholizadeh S, and Moalemnia M
- Abstract
Objectives: This study assessed the effects of two remineralizing agents namely MI Paste Plus containing casein phosphopeptide amorphous calcium phosphate fluoride (CPP-ACFP) and Remin Pro containing hydroxyapatite, fluoride and xylitol (HFX) with/without erbium-doped yttrium aluminium garnet (Er:YAG) and CO
2 laser irradiation on demineralized enamel microhardness. Materials and Methods: In this in vitro study, 70 sound human premolars were mesiodistally sectioned, demineralized at a pH of 4.6 for 8 hours, and randomly divided into 7 remineralization groups (n=10): of (I) MI Paste Plus (CPP-ACFP), (II) Remin Pro (HFX), (III) MI Paste Plus+CO2 laser (0.7 W power, 50 Hz), (IV) Remin Pro+CO2 laser, (V) MI Paste Plus+Er:YAG laser (1 W power, 10 Hz), (VI) Remin Pro+Er:YAG laser, and (VII) negative control. The Vickers hardness number of specimens was then measured. The groups were compared by one-way ANOVA and Tukey's test (α=0.05). Results: The mean microhardness was 319.8±49.9, 325.3±44.6, 359.4±35.7, 296.4±33.7, 319.9±58.1, 358.9±28.4, and 240.0±41.6 kg/mm2 in groups 1 to 7, respectively. The difference in microhardness was significant among the groups (P<0.0001). Pairwise comparisons revealed significant differences in microhardness between all groups (P≤0.03) except between groups 1 and 2, 1 and 5, 2 and 5, and 3 and 6 (P>0.05). Conclusion: Both Remin Pro (containing HFX) and MI Paste Plus (containing CPP-ACFP) can cause enamel remineralization. MI Paste Plus+CO2 laser irradiation and Remin Pro+Er:YAG laser irradiation were significantly more effective than the application of each remineralizing agent alone ., Competing Interests: None declared., (Copyright © 2024 The Authors. Published by Tehran University of Medical Sciences.)- Published
- 2024
- Full Text
- View/download PDF
49. Mitochondrial transfer from cancer-associated fibroblasts increases migration in aggressive breast cancer.
- Author
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Goliwas KF, Libring S, Berestesky E, Gholizadeh S, Schwager SC, Frost AR, Gaborski TR, Zhang J, and Reinhart-King CA
- Subjects
- Humans, Female, Cell Line, Tumor, Mitochondria metabolism, Adenosine Triphosphate metabolism, Fibroblasts metabolism, Tumor Microenvironment, Breast Neoplasms pathology, Cancer-Associated Fibroblasts metabolism
- Abstract
Cancer-associated fibroblasts (CAFs) have distinct roles within the tumor microenvironment, which can impact the mode and efficacy of tumor cell migration. CAFs are known to increase invasion of less-aggressive breast cancer cells through matrix remodeling and leader-follower dynamics. Here, we demonstrate that CAFs communicate with breast cancer cells through the formation of contact-dependent tunneling nanotubes (TNTs), which allow for the exchange of cargo between cell types. CAF mitochondria are an integral cargo component and are sufficient to increase the 3D migration of cancer cells. This cargo transfer results in an increase in mitochondrial ATP production in cancer cells, whereas it has a negligible impact on glycolytic ATP production. Manually increasing mitochondrial oxidative phosphorylation (OXPHOS) by providing extra substrates for OXPHOS fails to enhance cancer cell migration unless glycolysis is maintained at a constant level. Together, these data indicate that tumor-stromal cell crosstalk via TNTs and the associated metabolic symbiosis is a finely controlled mechanism by which tumor cells co-opt their microenvironment to promote cancer progression and may become a potential therapeutic target., Competing Interests: Competing interests The authors declare no competing or financial interests., (© 2023. Published by The Company of Biologists Ltd.)
- Published
- 2023
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50. Molecular analysis of acetylcholinesterase gene in field-collected populations of Musca domestica (Diptera: Muscidae) in Northwestern Iran.
- Author
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Adib D, Jafari A, Silivanova E, Basseri H, and Gholizadeh S
- Subjects
- Animals, Acetylcholinesterase genetics, Iran, Nucleotides, Muscidae, Houseflies genetics, Insecticides pharmacology
- Abstract
Nowadays, pyrethroid (Py) insecticides are commonly used against household insect pests and housefly. The combination of Py and organophosphates (OP) are also utilized to combat these insects. The resistance status of Iranian housefly populations to them and carbamate (CB) insecticides is uncertain. This study investigates the presence of acetylcholinesterase (AChE) mutations related to the resistance of Musca domestica to OP and/or CB insecticides in Northwestern Iran. Nucleotides 1041-1776, based on their positions in the ACE gene of aabys strain, were amplified and sequenced in houseflies collected from West Azerbaijan, Gilan, and Ardebil Provinces, Iran. Among 12 single-nucleotide polymorphisms detected, 3 mismatches were found at nucleotides 1174 (T/A, G), 1473 (G/T, C), and 1668 (T/A), leading to amino acid substitutions in V260L, G342A/V, and F407Y positions with various combinations. Genotyping results showed that 85% of specimens had at least one of these substitutions. In addition, the Iranian housefly population was composed of 5 insensitive and sensitive alleles. For the first time, the current study reports the presence of V260L, G342A, G342V, and F407Y substitutions in M. domestica specimens collected from Northwestern Iran. The selection of multiple alleles in field populations might be due to the application of various pesticides/insecticides during extended periods in the region. These molecular levels signify the presence of control problems in the area and the need for developing effective control strategies for such populations., (© The Author(s) 2023. Published by Oxford University Press on behalf of Entomological Society of America.)
- Published
- 2023
- Full Text
- View/download PDF
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