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2. Sex- and Age-Dependent Changes in Polysensitization to Common Aeroallergens Over 20 Years

Author

Beutner C, Forkel S, Gupta S, Fuchs T, Schön MP, Geier J, and Buhl T

Subjects
aeroallergens, polysensitization, sensitization pattern, skin prick test, Immunologic diseases. Allergy, RC581-607
Abstract

Caroline Beutner,1 Susann Forkel,1 Sidhi Gupta,1 Thomas Fuchs,1 Michael P Schön,1,2 Johannes Geier,2,3 Timo Buhl1,2 1Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany; 2Lower Saxony Institute of Occupational Dermatology, University Medical Center Göttingen, Göttingen, Germany; 3Information Network of Departments of Dermatology (IVDK), University of Göttingen, Göttingen, GermanyCorrespondence: Caroline BeutnerDepartment of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Georg August University, Robert Koch-Str. 40, Göttingen D-37075, GermanyTel +495513966402Email caroline.beutner@med.uni-goettingen.deIntroduction: The prevalence of airway allergies in Europe has increased from 23% to 31% in recent years. Polysensitization is associated with the development and severity of relevant allergies, particularly allergic asthma.Objective: We investigated age- and sex-dependent monosensitization and polysensitization profiles as well as patterns of sensitization using skin prick test (SPT) reactivity to the most common aeroallergens.Patients and Methods: From 1998 to 2017, SPTs were retrospectively analyzed in 2886 symptomatic patients, referred to the University Medical Center Göttingen, located in central Germany. The major aeroallergen groups early flowering tree pollen, grass pollen, and house dust mites were evaluated in this study. Wheal diameters ≥ 2 mm were considered positive during the entire study period.Results: Polysensitization to the most common aeroallergen groups increased significantly over 20 years. Boys and young men displayed the most remarkable rise in total sensitization rates in our study group over time.Discussion: Our patient-based study demonstrates a continuing increase in polysensitization rates over the last 20 years, with boys and young men being most frequently affected. Our data—without being a population-based study—suggest a scenario with climbing rates of allergic rhinitis and asthma.Keywords: aeroallergens, polysensitization, sensitization pattern, skin prick test

Published
2020

10. Allergiezentrum Südniedersachsen – Das Comprehensive Allergy Center der Universitätsmedizin Göttingen

Author

Lex, C., primary, Beutner, D., additional, Buhl, T., additional, Czech-Zechmeister, B.A., additional, Dombrowski, T., additional, Ellenrieder, V., additional, Fischer, A., additional, Geier, J., additional, Gliem, N., additional, Hasenfuß, G., additional, Olgemöller, U., additional, Paul, T., additional, Schön, M.P., additional, and Beutner, C., additional

Published
2022
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11. S1-Leitlinie Kontaktekzem

Author

Dickel, H., primary, Bauer, A., additional, Brehler, R., additional, Mahler, V., additional, Merk, H.F., additional, Neustädter, I., additional, Strömer, K., additional, Werfel, T., additional, Worm, M., additional, and Geier, J., additional

Published
2022
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31. Is benzyl alcohol a significant contact sensitizer?

Author

Geier, J., Ballmer‐Weber, B., Buhl, T., Rieker‐Schwienbacher, J., Mahler, V., Dickel, H., Schubert, S., Baron, Jens Malte, Grabbe, Jürgen, Siedlecki, Katharina, Strom, Kerstin, Hartmann, Karin, Worm, Margitta, Simon, Dagmar, Effendy, Isaak, Dickel, Heinrich, Fartasch, Manigé, Vieluf, Dieter, Beiteke, Ulrike, and Bauer, Andrea

Subjects
*BENZYL alcohol, *ALLERGENS, *INFORMATION networks, *RELIABILITY in engineering, *TEST reliability
Abstract

Background: Benzyl alcohol is a widely used preservative, solvent and fragrance material. According to published data, it is a rare sensitizer in humans. Objectives: To identify characteristics and sensitization patterns of patients with positive patch test reactions to benzyl alcohol and to check the reliability of the patch test preparation benzyl alcohol 1% pet. Patients and Methods: Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK), 2010–2019. Results: Of 70 867 patients patch tested with benzyl alcohol 1% pet., 146 (0.21%) showed a positive reaction, most of them (89%) only weakly positive. The number of doubtful and irritant reactions significantly exceeded the number of positive reactions. Reproducibility of positive test reactions was low. Among benzyl alcohol‐positive patients, compared to benzyl alcohol‐negative patients, there were significantly more patients with leg dermatitis (17.8% vs. 8.6%), more patients aged 40 years or more (81.5% vs. 70.5%) and more patients who were tested because of a suspected intolerance reaction to topical medications (34.9% vs. 16.6%). Concomitant positive reactions were mainly seen to fragrances, preservatives and ointment bases. Conclusions: Sensitization to benzyl alcohol occurs very rarely, mainly in patients with stasis dermatitis. In view of our results, benzyl alcohol cannot be regarded as a significant contact allergen, and therefore marking it as skin sensitizer 1B and labelling it with H 317 is not helpful. [ABSTRACT FROM AUTHOR]

Published
2022
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33. A survey of members of the European Surveillance System on Contact Allergy and the EU project 'StanDerm' to identify allergens tested in cosmetic series across Europe

Author

Horton, E., Wilkinson, M., Aalto-Korte, K., Pesonen, M., Bauer, A., Chowdhury, M. M. U., Cooper, S., Cousen, P., Crepy, M. -N., Larese Filon F, F., Gallo, R., Geier, J., Gimenez-Arnau, A., Goncalo, M., Goossens, A., Green, C., Guarneri, F., Ljubojevic Hadzavdic, S., Johansen, J. D., Johnston, G. A., Rustemeyer, T., Sanchez-Perez, J., Thyssen, J. P., Schuttelaar, M. -L. A., Stone, N., Uter, W., Belloni Fortina, A, Public Health Research (PHR), Dermatology, and AII - Inflammatory diseases

Subjects
Allergic Contact, diagnosis, media_common.quotation_subject, llergic contact dermatitis, cosmetic diagnosis, sensitisers, dermatitis, Practice Patterns, Dermatology, Cosmetics, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Environmental health, Immunology and Allergy, Medicine, Humans, Public Health Surveillance, 030212 general & internal medicine, European Union, Practice Patterns, Physicians', Baseline (configuration management), cosmetic, media_common, Physicians', business.industry, SENSITIZERS, allergic contact dermatitis, Allergens, Dermatitis, Allergic Contact, Europe, Health Surveys, Patch Tests, 3. Good health, DERMATITIS, Contact allergy, Current practice, business
Abstract

Background: There is currently no agreed cosmetic series for use across Europe.Objectives: To establish allergens currently tested in local and national cosmetic series.Method: Members of the European Surveillance System on Contact Allergy and the European Cooperation in Science and Technology project TD1206 ("StanDerm") were surveyed to establish their current practice.Results: A wide range of allergens was tested but there was significant variation between centres on the allergens considered to be important in screening for allergy to cosmetics. The number of allergens tested in addition to the baseline series varied between 2 and 50.Conclusions: There is a need for further investigation to establish the frequency and relevance of reactions to cosmetic allergens to enable an agreed evidence-based cosmetic series to be produced. Criteria for inclusion need to be established.

Published
2020

39. Beurteilung der Auswirkung einer arbeitsbedingten Allergie gegenüber Meerestieren bei der Minderung der Erwerbsfähigkeit im Rahmen der BK 5101

Author

Dickel, H., primary, Kuehn, A., additional, Dickel, B., additional, Bauer, A., additional, Becker, D., additional, Fartasch, M., additional, Häberle, M., additional, John, S.M., additional, Mahler, V., additional, Skudlik, C., additional, Weisshaar, E., additional, Werfel, T., additional, Geier, J., additional, and Diepgen†, T.L., additional

Published
2020
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44. Atopy patch testing with aeroallergens in a large clinical population of dermatitis patients in Germany and Switzerland, 2000‐2015: a retrospective multicentre study

Author

Dickel, H., primary, Kuhlmann, L., additional, Bauer, A., additional, Bircher, A.J., additional, Breuer, K., additional, Fuchs, T., additional, Grabbe, J., additional, Mahler, V., additional, Pföhler, C., additional, Przybilla, B., additional, Rieker‐Schwienbacher, J., additional, Schröder‐Kraft, C., additional, Simon, D., additional, Treudler, R., additional, Weisshaar, E., additional, Worm, M., additional, Trinder, E., additional, and Geier, J., additional

Published
2020
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48. Erratum: Contact sensitization to plants of the Compositae family: Data of the Information Network of Departments of Dermatology (IVDK) from 2007 to 2016 (vol 80, pg 222, 2019)

Author

Baron, J. M., Grabbe, J., Ludwig, A., Bircher, A., Laubstein, B., Zuberbier, T., Worm, M., Simon, D., Effendy, Isaak, Dickel, H., Fartasch, M., Meyersburg, D., Patsinakidis, N., Zutt, M., Große-Hüttmann, P., Hausenblas, P., Martin, V., Reich, K., Breuer, K., Vieluf, D., Jung, A., Lippert, U., Pilz, B., Frosch, P. J., Mydlach, B., Pirker, C., Herbst, R., Kügler, K., Beiteke, U., Richter, G., Aschoff, R., Spornraft-Ragaller, P., Bauer, A., Koch, A., Peters, K. -P., Diepgen, T. L., Hertl, M., Mahler, V., Wagner, N., Ockenfels, H. -M., Hillen, U., Schwantes, H., Szliska, Ch., Geier, J., Meyer, J., Grunwald-Delitz, H., Kaatz, M., Kränke, B., Aberer, W., Jünger, M., Fuchs, Th., Buhl, T., Gaber, G., Lübbe, D., Kreft, B., Kiehn, M., Wessbecher, R., Coors, E., Witte, J., Seemann, U., Schröder-Kraft, C., Schaefer, T., Werfel, Th., Kapp, A., Schulze-Dirks, A., Hartmann, M., Jappe, U., Schäkel, K., Weisshaar, E., Löffler, H., Bahmer, F. A., Koch, P., Pföhler, C., Gebhardt, M., Wigger-Alberti, W., Schliemann, S., Brasch, J., Spring, P., Curdin, C., Treudler, R., Nestoris, St., Shimanovich, I., Hartmann, K., Recke, A., Becker, D., Bayerl, Ch., Kurzen, H., Booken, D., Klemke, C. -D., Ludwig-Peitsch, W., Schmieder, A., Pfützner, W., Hoffmann, J., Stadler, R., Oppel, T., Przybilla, B., Thomas, P., Schuh, T., Eben, R., Molin, S., Agathos, M., Ramrath, K., Georgi, M., Isbary, G., Rakoski, J., Darsow, U., Biedermann, T., Hellweg, B., Brehler, R., Behring, M., Müller, I., Debus, D., Bachtler, A., Ertner, K., Baur, V., Padeken, M., Kautz, O., Uter, W., John, S. M., Schwanitz, H. J., Schürer, N., Skudlik, Ch., Prager, W., Heise, H., Trcka, J., Rothaupt, D., Plaza, T., Nist, G., Rieker-Schwienbacher, J., Lischka, G., Roecken, M., Fischer, J., Staib, G., Hinrichs, R., Weiss, J., Arnold, J., Trautmann, A., Knopf, B., Teubner, D., Mechtel, D., Ballmer-Weber, B., and Navarini, A.

Published
2019

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