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6. ICAP‐1 loss impairs CD8 + thymocyte development and leads to reduced marginal zone B cells in mice

Author

Sevilla‐Movilla, Silvia, primary, Fuentes, Patricia, additional, Rodríguez‐García, Yaiza, additional, Arellano‐Sánchez, Nohemi, additional, Krenn, Peter W., additional, de Val, Soledad Isern, additional, Montero‐Herradón, Sara, additional, García‐Ceca, Javier, additional, Burdiel‐Herencia, Valeria, additional, Gardeta, Sofía R., additional, Aguilera‐Montilla, Noemí, additional, Barrio‐Alonso, Celia, additional, Crainiciuc, Georgiana, additional, Bouvard, Daniel, additional, García‐Pardo, Angeles, additional, Zapata, Agustin G., additional, Hidalgo, Andrés, additional, Fässler, Reinhard, additional, Carrasco, Yolanda R., additional, Toribio, Maria L., additional, and Teixidó, Joaquin, additional

Published
2022
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7. ICAP‐1 loss impairs CD8+ thymocyte development and leads to reduced marginal zone B cells in mice.

Author

Sevilla‐Movilla, Silvia, Fuentes, Patricia, Rodríguez‐García, Yaiza, Arellano‐Sánchez, Nohemi, Krenn, Peter W., de Val, Soledad Isern, Montero‐Herradón, Sara, García‐Ceca, Javier, Burdiel‐Herencia, Valeria, Gardeta, Sofía R., Aguilera‐Montilla, Noemí, Barrio‐Alonso, Celia, Crainiciuc, Georgiana, Bouvard, Daniel, García‐Pardo, Angeles, Zapata, Agustin G., Hidalgo, Andrés, Fässler, Reinhard, Carrasco, Yolanda R., and Toribio, Maria L.

Subjects
B cells, CELL physiology, CELL adhesion, TRANSCRIPTION factors, THYMOCYTES
Abstract

ICAP‐1 regulates β1‐integrin activation and cell adhesion. Here, we used ICAP‐1‐null mice to study ICAP‐1 potential involvement during immune cell development and function. Integrin α4β1‐dependent adhesion was comparable between ICAP‐1‐null and control thymocytes, but lack of ICAP‐1 caused a defective single‐positive (SP) CD8+ cell generation, thus, unveiling an ICAP‐1 involvement in SP thymocyte development. ICAP‐1 bears a nuclear localization signal and we found it displayed a strong nuclear distribution in thymocytes. Interestingly, there was a direct correlation between the lack of ICAP‐1 and reduced levels in SP CD8+ thymocytes of Runx3, a transcription factor required for CD8+ thymocyte generation. In the spleen, ICAP‐1 was found evenly distributed between cytoplasm and nuclear fractions, and ICAP‐1–/– spleen T and B cells displayed upregulation of α4β1‐mediated adhesion, indicating that ICAP‐1 negatively controls their attachment. Furthermore, CD3+‐ and CD19+‐selected spleen cells from ICAP‐1‐null mice showed reduced proliferation in response to T‐ and B‐cell stimuli, respectively. Finally, loss of ICAP‐1 caused a remarkable decrease in marginal zone B‐ cell frequencies and a moderate increase in follicular B cells. Together, these data unravel an ICAP‐1 involvement in the generation of SP CD8+ thymocytes and in the control of marginal zone B‐cell numbers. [ABSTRACT FROM AUTHOR]

Published
2022
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11. Metodología para la auditoría de sistemas Big Data

Author

García Ceca, Javier

Subjects
Aplicación Informática
Abstract

El Big Data ha supuesto una tecnología disruptiva que ha cambiado la forma en la que se hacen los negocios. Ahora, las organizaciones disponen de sistemas que son capaces de tomar decisiones en base a análisis ejecutados sobre los datos recogidos de sus actividades u otras fuentes. Big Data se encarga de almacenar, manipular y analizar estos datos. Esto puede suponer un problema si estos datos no están siendo gestionados de forma correcta. El entorno Big Data dentro de una organización debe estar sujeto a unas normas que aseguren la correcta manipulación de este, que puede abarcar desde las técnicas de tratamiento de los datos dentro del sistema hasta el cumplimiento de la regulación presente en el país en el que opera la organización. Por ello, estos sistemas necesitan ser revisados y aprobados dentro de un marco de auditoría que recoja las características propias de un sistema Big Data. Este TFM propone una metodología de auditoría para esta clase de sistemas como objetivo principal. Con esta metodología el auditor será capaz de identificar, probar y verificar los controles específicos implementados en las distintas partes de un sistema Big Data., Big Data is a groundbreaker technology that has changed the way business is done. Nowadays, organizations have systems which can make decisions based on analysis of data they collect either from their own activities or from other sources. Big Data is in charge of storing, handling and analyzing that data. This could pose a problem if data is not managed correctly. Within any organization, Big Data must be subject to regulations which assure its correct use. These regulations may include data processing techniques of the system, as well as the compliance with the current regulation of the country where the organization operates. Therefore, these systems need to be revised and approved within an audit framework which holds the specific characteristics of a Big Data system. This essay puts forward an auditing methodology for this type of systems, as its main objective. With this methodology , the auditor will be able to identify, test and verify the specific controls implemented in the different parts of a Big Data

Published
2018

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