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2. Author Correction: Mapping the genomic landscape of CRISPR–Cas9 cleavage

Author

Cameron, Peter, Fuller, Chris K., Donohoue, Paul D., Jones, Brittnee N., Thompson, Matthew S., Carter, Matthew M., Gradia, Scott, Vidal, Bastien, Garner, Elizabeth, Slorach, Euan M., Lau, Elaine, Banh, Lynda M., Lied, Alexandra M., Edwards, Leslie S., Settle, Alexander H., Capurso, Daniel, Llaca, Victor, Deschamps, Stéphane, Cigan, Mark, Young, Joshua K., and May, Andrew P.

Published
2023
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4. Robust SARS-CoV-2-specific and heterologous immune responses in vaccine-naïve residents of long-term care facilities who survive natural infection

Author

Tut, Gokhan, Lancaster, Tara, Butler, Megan S., Sylla, Panagiota, Spalkova, Eliska, Bone, David, Kaur, Nayandeep, Bentley, Christopher, Amin, Umayr, Jadir, Azar T., Hulme, Samuel, Ayodel, Morenike, Dowell, Alexander C., Pearce, Hayden, Zuo, Jianmin, Margielewska-Davies, Sandra, Verma, Kriti, Nicol, Samantha, Begum, Jusnara, Jinks, Elizabeth, Tut, Elif, Bruton, Rachel, Krutikov, Maria, Shrotri, Madhumita, Giddings, Rebecca, Azmi, Borscha, Fuller, Chris, Irwin-Singer, Aidan, Hayward, Andrew, Copas, Andrew, Shallcross, Laura, and Moss, Paul

Published
2022
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6. Generation of a Commercial-Scale Founder Population of Porcine Reproductive and Respiratory Syndrome Virus Resistant Pigs Using CRISPR-Cas

Author

Burger, Brian T., primary, Beaton, Benjamin P., additional, Campbell, Matthew A., additional, Brett, Benjamin T., additional, Rohrer, Melissa S., additional, Plummer, Sarah, additional, Barnes, Dylan, additional, Jiang, Ke, additional, Naswa, Sudhir, additional, Lange, Jeremy, additional, Ott, Alina, additional, Alger, Elizabeth, additional, Rincon, Gonzalo, additional, Rounsley, Steven, additional, Betthauser, Jeff, additional, Mtango, Namdori R., additional, Benne, Joshua A., additional, Hammerand, Jessica, additional, Durfee, Codie J., additional, Rotolo, Marisa L., additional, Cameron, Peter, additional, Lied, Alexandra M., additional, Irby, Matthew J., additional, Nyer, David B., additional, Fuller, Chris K., additional, Gradia, Scott, additional, Kanner, Steven B., additional, Park, Ki-Eun, additional, Waters, Jerel, additional, Simpson, Sean, additional, Telugu, Bhanu P., additional, Salgado, Brianna C., additional, Brandariz-Nuñez, Alberto, additional, Rowland, Raymond R.R., additional, Culbertson, Matt, additional, Rice, Elena, additional, and Cigan, A. Mark, additional

Published
2024
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7. Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance

Author

Li, Ming, Luo, Xiong-jian, Landén, Mikael, Bergen, Sarah E, Hultman, Christina M, Li, Xiao, Zhang, Wen, Yao, Yong-Gang, Zhang, Chen, Liu, Jiewei, Mattheisen, Manuel, Cichon, Sven, Mühleisen, Thomas W, Degenhardt, Franziska A, Nöthen, Markus M, Schulze, Thomas G, Grigoroiu-Serbanescu, Maria, Li, Hao, Fuller, Chris K, Chen, Chunhui, Dong, Qi, Chen, Chuansheng, Jamain, Stéphane, Leboyer, Marion, Bellivier, Frank, Etain, Bruno, Kahn, Jean-Pierre, Henry, Chantal, Preisig, Martin, Kutalik, Zoltán, Castelao, Enrique, Wright, Adam, Mitchell, Philip B, Fullerton, Janice M, Schofield, Peter R, Montgomery, Grant W, Medland, Sarah E, Gordon, Scott D, Martin, Nicholas G, Rietschel, Marcella, Liu, Chunyu, Kleinman, Joel E, Hyde, Thomas M, Weinberger, Daniel R, and Su, Bing

Subjects
Biological Psychology, Epidemiology, Health Sciences, Psychology, Serious Mental Illness, Neurosciences, Mental Health, Brain Disorders, Human Genome, Genetics, Clinical Research, Prevention, 2.1 Biological and endogenous factors, Aetiology, Mental health, Aged, Bayes Theorem, Bipolar Disorder, Case-Control Studies, Chromosomes, Human, Pair 22, Cognition, Genetic Predisposition to Disease, Genome-Wide Association Study, Hippocampus, Humans, Logistic Models, Polymorphism, Single Nucleotide, MooDS Consortium, Swedish Bipolar Study Group, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Biomedical and clinical sciences, Health sciences
Abstract

BACKGROUND:Bipolar disorder is a highly heritable polygenic disorder. Recent enrichment analyses suggest that there may be true risk variants for bipolar disorder in the expression quantitative trait loci (eQTL) in the brain. AIMS:We sought to assess the impact of eQTL variants on bipolar disorder risk by combining data from both bipolar disorder genome-wide association studies (GWAS) and brain eQTL. METHOD:To detect single nucleotide polymorphisms (SNPs) that influence expression levels of genes associated with bipolar disorder, we jointly analysed data from a bipolar disorder GWAS (7481 cases and 9250 controls) and a genome-wide brain (cortical) eQTL (193 healthy controls) using a Bayesian statistical method, with independent follow-up replications. The identified risk SNP was then further tested for association with hippocampal volume (n = 5775) and cognitive performance (n = 342) among healthy individuals. RESULTS:Integrative analysis revealed a significant association between a brain eQTL rs6088662 on chromosome 20q11.22 and bipolar disorder (log Bayes factor = 5.48; bipolar disorder P = 5.85 × 10(-5)). Follow-up studies across multiple independent samples confirmed the association of the risk SNP (rs6088662) with gene expression and bipolar disorder susceptibility (P = 3.54 × 10(-8)). Further exploratory analysis revealed that rs6088662 is also associated with hippocampal volume and cognitive performance in healthy individuals. CONCLUSIONS:Our findings suggest that 20q11.22 is likely a risk region for bipolar disorder; they also highlight the informative value of integrating functional annotation of genetic variants for gene expression in advancing our understanding of the biological basis underlying complex disorders, such as bipolar disorder.

Published
2016

10. Harnessing type I CRISPR–Cas systems for genome engineering in human cells

Author

Cameron, Peter, Coons, Mary M., Klompe, Sanne E., Lied, Alexandra M., Smith, Stephen C., Vidal, Bastien, Donohoue, Paul D., Rotstein, Tomer, Kohrs, Bryan W., Nyer, David B., Kennedy, Rachel, Banh, Lynda M., Williams, Carolyn, Toh, Mckenzi S., Irby, Matthew J., Edwards, Leslie S., Lin, Chun-Han, Owen, Arthur L. G., Künne, Tim, van der Oost, John, Brouns, Stan J. J., Slorach, Euan M., Fuller, Chris K., Gradia, Scott, Kanner, Steven B., May, Andrew P., and Sternberg, Samuel H.

Published
2019
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12. Allogeneic chimeric antigen receptor-T cells with CRISPR-disrupted programmed death-1 checkpoint exhibit enhanced functional fitness

Author

Lau, Elaine, primary, Kwong, George, additional, Fowler, Tristan W., additional, Sun, Bee-Chun, additional, Donohoue, Paul D., additional, Davis, Ryan T., additional, Bryan, Mara, additional, McCawley, Shannon, additional, Clarke, Starlynn C., additional, Williams, Carolyn, additional, Banh, Lynda, additional, Irby, Matthew, additional, Edwards, Leslie, additional, Storlie, Meghan, additional, Kohrs, Bryan, additional, Lilley, Graham W.J., additional, Smith, Stephen C., additional, Gradia, Scott, additional, Fuller, Chris K., additional, Skoble, Justin, additional, Garner, Elizabeth, additional, van Overbeek, Megan, additional, and Kanner, Steven B., additional

Published
2023
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13. Outcomes of SARS-CoV-2 omicron infection in residents of long-term care facilities in England (VIVALDI): a prospective, cohort study

Author

Krutikov, Maria, Stirrup, Oliver, Nacer-Laidi, Hadjer, Azmi, Borscha, Fuller, Chris, Tut, Gokhan, Palmer, Tom, Shrotri, Madhumita, Irwin-Singer, Aidan, Baynton, Verity, Hayward, Andrew, Moss, Paul, Copas, Andrew, Shallcross, Laura, The COVID-19 Genomics UK (COG-UK) Consortium, Smith, Darren, Bashton, Matthew, McCann, Clare, Young, Greg, Nelson, Andrew, Crown, Matthew, Henderson, John, Hollis, Amy, Stanley, William, and Yew, Wen Chyin

Subjects
Aged, 80 and over, Male, Health (social science), SARS-CoV-2, COVID-19, B100, C500, Long-Term Care, State Medicine, Cohort Studies, Psychiatry and Mental health, Humans, Female, Prospective Studies, Geriatrics and Gerontology, Family Practice
Abstract

Background: The SARS-CoV-2 omicron variant (B.1.1.529) is highly transmissible, but disease severity appears to be reduced compared with previous variants such as alpha and delta. We investigated the risk of severe outcomes following infection in residents of long-term care facilities. Methods: We did a prospective cohort study in residents of long-term care facilities in England who were tested regularly for SARS-CoV-2 between Sept 1, 2021, and Feb 1, 2022, and who were participants of the VIVALDI study. Residents were eligible for inclusion if they had a positive PCR or lateral flow device test during the study period, which could be linked to a National Health Service (NHS) number, enabling linkage to hospital admissions and mortality datasets. PCR or lateral flow device test results were linked to national hospital admission and mortality records using the NHS-number-based pseudo-identifier. We compared the risk of hospital admission (within 14 days following a positive SARS-CoV-2 test) or death (within 28 days) in residents who had tested positive for SARS-CoV-2 in the period shortly before omicron emerged (delta-dominant) and in the omicron-dominant period, adjusting for age, sex, primary vaccine course, past infection, and booster vaccination. Variants were confirmed by sequencing or spike-gene status in a subset of samples. Results: 795 233 tests were done in 333 long-term care facilities, of which 159 084 (20·0%) could not be linked to a pseudo-identifier and 138 012 (17·4%) were done in residents. Eight residents had two episodes of infection (>28 days apart) and in these cases the second episode was excluded from the analysis. 2264 residents in 259 long-term care facilities (median age 84·5 years, IQR 77·9–90·0) were diagnosed with SARS-CoV-2, of whom 253 (11·2%) had a previous infection and 1468 (64·8%) had received a booster vaccination. About a third of participants were male. Risk of hospital admissions was markedly lower in the 1864 residents infected in the omicron-period (4·51%, 95% CI 3·65–5·55) than in the 400 residents infected in the pre-omicron period (10·50%, 7·87–13·94), as was risk of death (5·48% [4·52–6·64] vs 10·75% [8·09–14·22]). Adjusted hazard ratios (aHR) also indicated a reduction in hospital admissions (0·64, 95% CI 0·41–1·00; p=0·051) and mortality (aHR 0·68, 0·44–1·04; p=0·076) in the omicron versus the pre-omicron period. Findings were similar in residents with a confirmed variant. Interpretation: Observed reduced severity of the omicron variant compared with previous variants suggests that the wave of omicron infections is unlikely to lead to a major surge in severe disease in long-term care facility populations with high levels of vaccine coverage or natural immunity. Continued surveillance in this vulnerable population is important to protect residents from infection and monitor the public health effect of emerging variants. Funding: UK Department of Health and Social Care.

Published
2022

14. NmeCas9 is an intrinsically high-fidelity genome-editing platform

Author

Amrani, Nadia, Gao, Xin D., Liu, Pengpeng, Edraki, Alireza, Mir, Aamir, Ibraheim, Raed, Gupta, Ankit, Sasaki, Kanae E., Wu, Tong, Donohoue, Paul D., Settle, Alexander H., Lied, Alexandra M., McGovern, Kyle, Fuller, Chris K., Cameron, Peter, Fazzio, Thomas G., Zhu, Lihua Julie, Wolfe, Scot A., and Sontheimer, Erik J.

Published
2018
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15. Mapping the genomic landscape of CRISPR–Cas9 cleavage

Author

Cameron, Peter, Fuller, Chris K, Donohoue, Paul D, Jones, Brittnee N, Thompson, Matthew S, Carter, Matthew M, Gradia, Scott, Vidal, Bastien, Garner, Elizabeth, Slorach, Euan M, Lau, Elaine, Banh, Lynda M, Lied, Alexandra M, Edwards, Leslie S, Settle, Alexander H, Capurso, Daniel, Llaca, Victor, Deschamps, Stéphane, Cigan, Mark, Young, Joshua K, and May, Andrew P

Published
2017
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17. Strong peak immunogenicity but rapid antibody waning following third vaccine dose in elderly residents of care homes

Author

Tut, Gokhan, primary, Lancaster, Tara, additional, Krutikov, Maria, additional, Sylla, Panagiota, additional, Bone, David, additional, Spalkova, Eliska, additional, Bentley, Christopher, additional, Amin, Umayr, additional, Jadir, Azar, additional, Hulme, Samuel, additional, Kaur, Nayandeep, additional, Tut, Elif, additional, Bruton, Rachel, additional, Wu, Mary, additional, Harvey, Ruth, additional, Carr, Edward, additional, Beale, Rupert, additional, Stirrup, Oliver, additional, Shrotri, Madhumita, additional, Azmi, Borscha, additional, Fuller, Chris, additional, Baynton, Verity, additional, Irwin-Singer, Aidan, additional, Hayward, Andrew, additional, Copas, Andrew, additional, Shallcross, Laura, additional, and Moss, Paul, additional

Published
2022
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18. Full Gradient Solution to Adaptive Hybrid Control

Author

Bean, Jacob, Schiller, Noah H, and Fuller, Chris

Subjects
Acoustics
Abstract

This paper focuses on the adaptation mechanisms in adaptive hybrid controllers. Most adaptive hybrid controllers update two filters individually according to the filtered reference least mean squares (FxLMS) algorithm. Because this algorithm was derived for feedforward control, it does not take into account the presence of a feedback loop in the gradient calculation. This paper provides a derivation of the proper weight vector gradient for hybrid (or feedback) controllers that takes into account the presence of feedback. In this formulation, a single weight vector is updated rather than two individually. An internal model structure is assumed for the feedback part of the controller. The full gradient is equivalent to that used in the standard FxLMS algorithm with the addition of a recursive term that is a function of the modeling error. Some simulations are provided to highlight the advantages of using the full gradient in the weight vector update rather than the approximation.

Published
2017

19. Severe Acute Respiratory Syndrome Coronavirus 2 Anti-Spike Antibody Levels Following Second Dose of ChAdOx1 nCov-19 or BNT162b2 Vaccine in Residents of Long-term Care Facilities in England (VIVALDI)

Author

Stirrup, Oliver, primary, Krutikov, Maria, additional, Tut, Gokhan, additional, Palmer, Tom, additional, Bone, David, additional, Bruton, Rachel, additional, Fuller, Chris, additional, Azmi, Borscha, additional, Lancaster, Tara, additional, Sylla, Panagiota, additional, Kaur, Nayandeep, additional, Spalkova, Eliska, additional, Bentley, Christopher, additional, Amin, Umayr, additional, Jadir, Azar, additional, Hulme, Samuel, additional, Giddings, Rebecca, additional, Nacer-Laidi, Hadjer, additional, Baynton, Verity, additional, Irwin-Singer, Aidan, additional, Hayward, Andrew, additional, Moss, Paul, additional, Copas, Andrew, additional, and Shallcross, Laura, additional

Published
2022
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20. Full Gradient Solution to Adaptive Hybrid Control

Author

Bean, Jacob, Schiller, Noah H, and Fuller, Chris

Subjects
Acoustics
Abstract

This paper focuses on the adaptation mechanisms in adaptive hybrid controllers. Most adaptive hybrid controllers update two filters individually according to the filtered-reference least mean squares (FxLMS) algorithm. Because this algorithm was derived for feedforward control, it does not take into account the presence of a feedback loop in the gradient calculation. This paper provides a derivation of the proper weight vector gradient for hybrid (or feedback) controllers that takes into account the presence of feedback. In this formulation, a single weight vector is updated rather than two individually. An internal model structure is assumed for the feedback part of the controller. The full gradient is equivalent to that used in the standard FxLMS algorithm with the addition of a recursive term that is a function of the modeling error. Some simulations are provided to highlight the advantages of using the full gradient in the weight vector update rather than the approximation.

Published
2016

21. Hybrid Feedforward-Feedback Noise Control Using Virtual Sensors

Author

Bean, Jacob, Fuller, Chris, and Schiller, Noah

Subjects
Acoustics
Abstract

Several approaches to active noise control using virtual sensors are evaluated for eventual use in an active headrest. Specifically, adaptive feedforward, feedback, and hybrid control structures are compared. Each controller incorporates the traditional filtered-x least mean squares algorithm. The feedback controller is arranged in an internal model configuration to draw comparisons with standard feedforward control theory results. Simulation and experimental results are presented that illustrate each controllers ability to minimize the pressure at both physical and virtual microphone locations. The remote microphone technique is used to obtain pressure estimates at the virtual locations. It is shown that a hybrid controller offers performance benefits over the traditional feedforward and feedback controllers. Stability issues associated with feedback and hybrid controllers are also addressed. Experimental results show that 15-20 dB reduction in broadband disturbances can be achieved by minimizing the measured pressure, whereas 10-15 dB reduction is obtained when minimizing the estimated pressure at a virtual location.

Published
2016

23. Profile of humoral and cellular immune responses to single doses of BNT162b2 or ChAdOx1 nCoV-19 vaccines in residents and staff within residential care homes (VIVALDI): an observational study

Author

Tut, Gokhan, primary, Lancaster, Tara, additional, Krutikov, Maria, additional, Sylla, Panagiota, additional, Bone, David, additional, Kaur, Nayandeep, additional, Spalkova, Eliska, additional, Bentley, Christopher, additional, Amin, Umayr, additional, Jadir, Azar T, additional, Hulme, Samuel, additional, Butler, Megan S, additional, Ayodele, Morenike, additional, Bruton, Rachel, additional, Shrotri, Madhumita, additional, Azmi, Borscha, additional, Fuller, Chris, additional, Irwin-Singer, Aidan, additional, Hayward, Andrew, additional, Copas, Andrew, additional, Shallcross, Laura, additional, and Moss, Paul, additional

Published
2021
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24. Robust SARS-CoV-2-specific and heterologous immune responses after natural infection in elderly residents of Long-Term Care Facilities

Author

Tut, Gokhan, primary, Lancaster, Tara, additional, Butler, Megan S., additional, Sylla, Panagiota, additional, Spalkova, Eliska, additional, Bone, David, additional, Kaur, Nayandeep, additional, Bentley, Christopher, additional, Amin, Umayr, additional, Jadir, Azar T., additional, Hulme, Samuel, additional, Ayodel, Morenike, additional, Dowell, Alexander C., additional, Pearce, Hayden, additional, Margielewska-Davies, Sandra, additional, Verma, Kriti, additional, Nicol, Samantha, additional, Begum, Jusnara, additional, Blakeway, D., additional, Jinks, Elizabeth, additional, Tut, Elif, additional, Bruton, Rachel, additional, Krutikov, Maria, additional, Shrotri, Madhumita, additional, Giddings, Rebecca, additional, Azmi, Borscha, additional, Fuller, Chris, additional, Irwin-Singer, Aidan, additional, Hayward, Andrew, additional, Copas, Andrew, additional, Shallcross, Laura, additional, and Moss, Paul, additional

Published
2021
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25. Incidence of SARS-CoV-2 infection according to baseline antibody status in staff and residents of 100 long-term care facilities (VIVALDI): a prospective cohort study

Author

Krutikov, Maria, primary, Palmer, Tom, additional, Tut, Gokhan, additional, Fuller, Chris, additional, Shrotri, Madhumita, additional, Williams, Haydn, additional, Davies, Daniel, additional, Irwin-Singer, Aidan, additional, Robson, James, additional, Hayward, Andrew, additional, Moss, Paul, additional, Copas, Andrew, additional, and Shallcross, Laura, additional

Published
2021
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26. Incidence of SARS-CoV-2 infection according to baseline antibody status in staff and residents of 100 Long Term Care Facilities (VIVALDI study)

Author

Krutikov, Maria, primary, Palmer, Tom, additional, Tut, Gokhan, additional, Fuller, Chris, additional, Shrotri, Madhumita, additional, Williams, Haydn, additional, Davies, Daniel, additional, Irwin-Singer, Aidan, additional, Robson, James, additional, Hayward, Andrew, additional, Moss, Paul, additional, Copas, Andrew, additional, and Shallcross, Laura, additional

Published
2021
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27. Uncertainty, insecurity, individual relative autonomy and the emancipatory potential of Galbraithian economics

Author

Fuller, Chris

Abstract

J. K. Galbraith’s economics may be ‘foundational’ to integrating Original Institutionalism and Post Keynesianism (Dunn, S. P. 2011. The Economics of John Kenneth Galbraith, Cambridge, UK, Cambridge University Press). This paper seeks a stronger justification of the emancipatory potential of structural interventionism favoured by the above approaches, by interpreting Galbraith’s ‘emancipation of belief’ as implying a self-trusting capacity, applying the argument to Galbraith’s theory of social balance and advocating a supporting notion of individual psychological balance. John Davis’s capabilities characterisation of ideal human psychological development is built upon, incorporating insecurity under uncertainty. Carl Rogers’ humanistic psychology is used to understand how actual and ideal psychological development diverge. Since Rogers’ work lacks institutional context but shares with Veblenian Evolutionary Economics an organismic view of the individual, a ‘middle range’ conception of the psychologically developing institutionalised individual emerges. A counterpart to a Galbraithian ‘organisational’ view of capitalisms, this ‘organismic’ conception explains how ‘social balance’ maintenance (i.e. structural intervention) may be necessary for psychologically balanced self-trusting individuals.

Published
2020

30. Feasibility study of hospital antimicrobial stewardship analytics using electronic health records

Author

Dutey-Magni, P F, primary, Gill, M J, additional, McNulty, D, additional, Sohal, G, additional, Hayward, A, additional, Shallcross, L, additional, Anderson, Niall, additional, Crayton, Elise, additional, Forbes, Gillian, additional, Jhass, Arnoupe, additional, Richardson, Emma, additional, Richardson, Michelle, additional, Rockenschaub, Patrick, additional, Smith, Catherine, additional, Sutton, Elizabeth, additional, Traina, Rosanna, additional, Atkins, Lou, additional, Conolly, Anne, additional, Denaxas, Spiros, additional, Fragaszy, Ellen, additional, Horne, Rob, additional, Kostkova, Patty, additional, Lorencatto, Fabiana, additional, Michie, Susan, additional, Mindell, Jennifer, additional, Robson, John, additional, Royston, Claire, additional, Tarrant, Carolyn, additional, Thomas, James, additional, West, Jonathan, additional, Williams, Haydn, additional, Elsay, Nadia, additional, and Fuller, Chris, additional

Published
2021
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32. Booster Vaccination Strongly Enhances SARS-CoV-2-Specific Antibody and Cellular Responses in Elderly Residents of Care Homes

Author

Tut, Gokhan, primary, Lancaster, Tara, additional, Krutikov, Maria, additional, Sylla, Panagiota, additional, Bone, David, additional, Spalkova, Eliska, additional, Bentley, Christopher, additional, Amin, Umayr, additional, Jadir, Azar, additional, Hulme, Samuel, additional, Kaur, Nayandeep, additional, Tut, Elif, additional, Bruton, Rachel, additional, Giddings, Rebecca, additional, Shrotri, Madhumita, additional, Azmi, Borscha, additional, Fuller, Chris, additional, Baynton, Verity, additional, Irwin-Singer, Aidan, additional, Hayward, Andrew C, additional, Copas, Andrew, additional, Shallcross, Laura, additional, and Moss, Paul, additional

Published
2021
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33. Reduced Antibody and Cellular Immune Responses Following Dual COVID-19 Vaccination Within Infection-Naïve Residents of Long-Term Care Facilities

Author

Tut, Gokhan, primary, Lancaster, Tara, additional, Butler, Megan S., additional, Bone, David, additional, Kaur, Nayandeep, additional, Spalkova, Eliska, additional, Bentley, Christopher, additional, Sylla, Panagiota, additional, Amin, Umayr, additional, Jadir, Azar, additional, Hulme, Samuel, additional, Ayodele, Morenike, additional, Murray, Duncan, additional, Greenwood, David, additional, Croft, Wayne, additional, Tut, Elif, additional, Bruton, Rachel, additional, Krutikov, Maria, additional, Giddings, Rebecca, additional, Shrotri, Madhumita, additional, Azmi, Borscha, additional, Fuller, Chris, additional, Irwin-Singer, Aidan, additional, Hayward, Andrew C, additional, Copas, Andrew, additional, Shallcross, Laura, additional, and Moss, Paul, additional

Published
2021
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34. Profile of Humoral and Cellular Immune Responses to Single BNT162b2 or ChAdOx1 Vaccine in Residents and Staff Within Residential Care Homes (VIVALDI Study)

Author

Tut, Gokhan, primary, Lancaster, Tara, additional, Krutikov, Maria, additional, Sylla, Panagiota, additional, Bone, David, additional, Kaur, Nayandeep, additional, Spalkova, Eliska, additional, Bentley, Christopher, additional, Amin, Umayr, additional, Jadir, Azar, additional, Hulme, Samuel, additional, Butler, Megan, additional, Ayodele, Morenike, additional, Bruton, Rachel, additional, Shrotri, Madhumita, additional, Azmi, Borscha, additional, Fuller, Chris, additional, Irwin-Singer, Aidan, additional, Hayward, Andrew C, additional, Copas, Andrew, additional, Shallcross, Laura, additional, and Moss, Paul, additional

Published
2021
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37. Additional file 1: of NmeCas9 is an intrinsically high-fidelity genome-editing platform

Author

Amrani, Nadia, Gao, Xin, Pengpeng Liu, Alireza Edraki, Mir, Aamir, Ibraheim, Raed, Gupta, Ankit, Sasaki, Kanae, Wu, Tong, Donohoue, Paul, Settle, Alexander, Lied, Alexandra, McGovern, Kyle, Fuller, Chris, Cameron, Peter, Fazzio, Thomas, Lihua Zhu, Wolfe, Scot, and Sontheimer, Erik

Abstract

Figure S1. (A) Sequences of sgRNAs associated with their respective DNA targets used in Fig. 1b. (B) Schematic representation of the split-GFP reporter system used in Figs. 1b, 2a, and 6a. Figure S2. NmeCas9 does not lead to an increase in γH2AX levels in mouse ESC or human HEK293T cells. Figure S3. SpyCas9 and NmeCas9 exhibit similar editing activity when targeting the AAVS1 locus. Figure S4. NmeCas9 and SpyCas9 editing efficiencies at dual target sites (DTSs) that can be cleaved by both enzymes. Figure S5. SITE-Seq read counts and heat map of the frequencies of indels by length at DTS3, DTS7, and DTS8 for SpyCas9 and NmeCas9. Figure S6. Positions of insertions and deletions at the DTS3, DTS7, and DTS8 sites. Figure S7. Sizes of insertions and deletions at the DTS3, DTS7, and DTS8 sites. Figure S8. Fractions of all mutations that are insertions or deletions at the DTS3, DTS7, and DTS8 sites for SpyCas9 and NmeCas9. Figure S9. As in Figure S6. Figure S10. As in Figure S7. Figure S11. GUIDE-seq read counts at NmeCas9 on- and off-target sites. Figure S12. Guide truncation series for Protospacer 9, NTS33 and NTS32. Figure S13. GUIDE-seq analysis to determine whether NmeCas9 sgRNA truncation leads to de novo off-target events. Figure S14. NmeCas9 guide length requirements at the NTS1C and NTS1C-OT1 editing sites. (PDF 5232 kb)

Published
2018
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41. Uncertainty, insecurity, individual relative autonomy and the emancipatory potential of Galbraithian economics.

Author

Fuller, Chris G

Subjects
DEVELOPMENTAL psychology, ECONOMICS, EVOLUTIONARY economics, HUMANISTIC psychology, UNCERTAINTY
Abstract

J. K. Galbraith's economics may be 'foundational' to integrating Original Institutionalism and Post Keynesianism (Dunn, S. P. 2011. The Economics of John Kenneth Galbraith, Cambridge, UK, Cambridge University Press). This paper seeks a stronger justification of the emancipatory potential of structural interventionism favoured by the above approaches, by interpreting Galbraith's 'emancipation of belief' as implying a self-trusting capacity, applying the argument to Galbraith's theory of social balance and advocating a supporting notion of individual psychological balance. John Davis's capabilities characterisation of ideal human psychological development is built upon, incorporating insecurity under uncertainty. Carl Rogers' humanistic psychology is used to understand how actual and ideal psychological development diverge. Since Rogers' work lacks institutional context but shares with Veblenian Evolutionary Economics an organismic view of the individual, a 'middle range' conception of the psychologically developing institutionalised individual emerges. A counterpart to a Galbraithian 'organisational' view of capitalisms, this 'organismic' conception explains how 'social balance' maintenance (i.e. structural intervention) may be necessary for psychologically balanced self-trusting individuals. [ABSTRACT FROM AUTHOR]

Published
2020
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43. NmeCas9 is an intrinsically high-fidelity genome editing platform

Author

Amrani, Nadia, primary, Gao, Xin D., additional, Liu, Pengpeng, additional, Edraki, Alireza, additional, Mir, Aamir, additional, Ibraheim, Raed, additional, Gupta, Ankit, additional, Sasaki, Kanae E., additional, Wu, Tong, additional, Donohoue, Paul D., additional, Settle, Alexander H., additional, Lied, Alexandra M., additional, McGovern, Kyle, additional, Fuller, Chris K., additional, Cameron, Peter, additional, Fazzio, Thomas G., additional, Zhu, Lihua Julie, additional, Wolfe, Scot A., additional, and Sontheimer, Erik J., additional

Published
2017
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46. 'Spielberg' Enlightens Viewers with Personal Portrait

Author

Fuller, Chris

Subjects
Movies, Movie directors, News, opinion and commentary, Sports and fitness
Abstract

Byline: Chris Fuller It's fitting that one of the most iconic monster-movie directors of all time now has a goliath of a documentary out about him and his work. HBO's [...]

Published
2017

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