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2. Oesophageal cell collection device and biomarker testing to identify high-risk Barrett's patients requiring endoscopic investigation

Author

Chien, Siobhan, primary, Glen, Paul, additional, Penman, Ian, additional, Cruickshank, Neil, additional, Bryce, Gavin, additional, Crumley, Andrew, additional, Phull, Perminder, additional, Miller, Michael, additional, Fletcher, Jonathan, additional, Gunjaca, Ivan, additional, Apollos, Jeyakumar, additional, Robertson, Kevin, additional, and Fullarton, Grant, additional

Published
2024
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3. Learning curves and the influence of procedural volume for the treatment of dysplastic Barrett’s esophagus

Author

Novelli, Marco, Banks, Matthew, Sehgal, Vinay, Graham, David, Sweis, Rami, Morris, Danielle, Miah, Haroon, Dunn, Jason M., Smart, Howard L., Bhandari, Pradeep, Smith, Lesley, Willert, Robert, Fullarton, Grant, Morris, John, Di Pietro, Massimiliano, Gordon, Charles, Penman, Ian, Barr, Hugh, Patel, Praful, Boger, Philip, Kapoor, Neil, Hoare, Jonathan, Direkze, Natalie, Ang, Yeng, Veitch, Andrew, Ragunath, Krish, Cheong, Edward, Dhar, Anjan, Nylander, David, Mahon, Brinder, Narayanasamy, Ravi, O’Toole, Dermot, Lipman, Gideon, Markar, Sheraz, Gupta, Abhinav, Haidry, Rehan J., and Lovat, Laurence B.

Published
2020
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6. National adoption of an esophageal cell collection device for Barrett's esophagus surveillance: impact on delay to investigation and pathological findings.

Author

Chien, Siobhan, Glen, Paul, Penman, Ian, Bryce, Gavin, Cruickshank, Neil, Miller, Michael, Crumley, Andrew, Fletcher, Jonathan, Phull, Perminder, Gunjaca, Ivan, Robertson, Kevin, Apollos, Jeyakumar, Fullarton, Grant, and group, the CytoSCOT

Subjects
BARRETT'S esophagus, TREATMENT delay (Medicine), HEALTH boards
Abstract

High quality Barrett's esophagus surveillance is crucial to detect early neoplastic changes. An esophageal cell collection device (OCCD) was introduced as a triage tool for Barrett's surveillance. This study aims to evaluate whether the Scottish OCCD program (CytoSCOT) has reduced delays to Barrett's surveillance, and whether delayed surveillance negatively impacts endoscopic pathology. All patients undergoing OCCD testing for Barrett's surveillance across 11 Scottish health boards between 14/9/2020 and 13/9/2022 were identified. Patients were dichotomised into two groups (Year 1 vs. Year 2), with individual records interrogated to record demographics, recommended surveillance interval, time from last endoscopy to OCCD test, and OCCD result. Patients were deemed high-risk if the OCCD demonstrated atypia and/or p53 positivity. Further analysis was performed on patients who underwent endoscopy within 12 months of OCCD testing. A total of 3223 OCCD tests were included in the analysis (1478 in Year 1; 1745 in Year 2). In Year 1 versus Year 2, there was a longer median delay to surveillance (9 vs. 5 months; P  < 0.001), increased proportion of patients with delayed surveillance (72.6% vs. 57.0%; P  < 0.001), and more high-risk patients (12.0% vs. 5.3%; P  < 0.001). 425/3223 patients (13.2%) were further investigated with upper gastrointestinal endoscopy, 57.9% of which were high-risk. As surveillance delay increased beyond 24 months, high-risk patients were significantly more likely to develop dysplasia or malignancy (P  = 0.004). Delayed Barrett's esophagus surveillance beyond 24 months is associated with increased risk of pre-cancerous pathology. The CytoSCOT program has reduced delays in surveillance, promoting earlier detection of dysplasia and reducing burden on endoscopy services. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Management of paraesophageal hiatus hernia

Author

Gerdes, Stephan, Schoppmann, Sebastian F, Bonavina, Luigi, Boyle, Nicholas, Mueller-Stich, Beat P, Gutschow, Christian A, Gisbertz, Suzanne Sarah, Kockerling, Ferdinand, Lehmann, Thorsten G, Lorenz, Dietmar, Granderath, Frank Alexander, Rosati, Riccardo, Wullstein, Christoph, Lundell, Lars, Cheong, Edward, Nafteux, Philippe, Olmi, Stefano, Monig, Stefan, Biebl, Matthias, Leers, Jessica, Zehetner, Joerg, Kristo, Ivan, Berrisford, Richard George, Skrobic, Ognjan M, Simic, Aleksandar P, Pera, Manuel, Grimminger, Peter Philipp, Gockel, Ines, Zarras, Konstantinos, Nieuwenhuijs, Vincent Bernard, Gossage, James A, Henegouwen, Mark I van Berge, Stein, Hubert J, Markar, Sheraz R, Hueting, Willem Eduard, Targarona, Eduardo M, Johansson, Jan, Macaulay, Graeme D, Wijnhoven, Bas PL, Benedix, Frank, Attwood, Stephen E, Hoelscher, Arnulf Heinrich, Priego, Pablo, Fuchs, Karl-Hermann, Luyer, Misha DP, Griffiths, Ewen A, Sovik, Torgeir Thorson, Theodorou, Dimitrios, Sgromo, Bruno, Salo, Jarmo A, Singhal, Rishi, Thorell, Anders, Zaninotto, Giovanni, Itenc, Marko, D'journo, Xavier Benoit, Fullarton, Grant M, Horbach, Thomas, Surgery, CCA - Cancer Treatment and Quality of Life, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and CCA - Cancer Treatment and quality of life

Subjects
REPAIR, MESH, Hiatus hernia, Mesh, Science & Technology, Fundoplication, Surgical technique, GUIDELINES, Paraesophageal hernia, REFLUX, Surgery, Delphi survey, RECURRENCE, Life Sciences & Biomedicine
Abstract

Aims There is considerable controversy regarding optimal management of patients with paraesophageal hiatus hernia (pHH). This survey aims at identifying recommended strategies for work-up, surgical therapy, and postoperative follow-up using Delphi methodology. Methods We conducted a 2-round, 33-question, web-based Delphi survey on perioperative management (preoperative work-up, surgical procedure and follow-up) of non-revisional, elective pHH among European surgeons with expertise in upper-GI. Responses were graded on a 5-point Likert scale and analyzed using descriptive statistics. Items from the questionnaire were defined as “recommended” or “discouraged” if positive or negative concordance among participants was > 75%. Items with lower concordance levels were labelled “acceptable” (neither recommended nor discouraged). Results Seventy-two surgeons with a median (IQR) experience of 23 (14–30) years from 17 European countries participated (response rate 60%). The annual median (IQR) individual and institutional caseload was 25 (15–36) and 40 (28–60) pHH-surgeries, respectively. After Delphi round 2, “recommended” strategies were defined for preoperative work-up (endoscopy), indication for surgery (typical symptoms and/or chronic anemia), surgical dissection (hernia sac dissection and resection, preservation of the vagal nerves, crural fascia and pleura, resection of retrocardial lipoma) and reconstruction (posterior crurorrhaphy with single stitches, lower esophageal sphincter augmentation (Nissen or Toupet), and postoperative follow-up (contrast radiography). In addition, we identified “discouraged” strategies for preoperative work-up (endosonography), and surgical reconstruction (crurorrhaphy with running sutures, tension-free hiatus repair with mesh only). In contrast, many items from the questionnaire including most details of mesh augmentation (indication, material, shape, placement, and fixation technique) were “acceptable”. Conclusions This multinational European Delphi survey represents the first expert-led process to identify recommended strategies for the management of pHH. Our work may be useful in clinical practice to guide the diagnostic process, increase procedural consistency and standardization, and to foster collaborative research.

Published
2023
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8. Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial

Author

Ragunath, Krish, Rameh, Bashir, Fullarton, Grant, Tucker, Art, Penman, Ian, Rodgers, Colin, Neale, James, Edwards, Cathryn, Wise, Adelyn, Jones, Stephen, Church, Nicholas, Vaidya, Kishor, Balata, Sherzad, Todd, John, Gibbons, Michael, Johnston, David, Anderson, Mark, Davies, Gareth, Dickey, William, Murdock, Andrew, Turner, Graham, Goddard, Andrew, Gore, Stephen, Haigh, Chris, Harding, Timothy, Jackson, Lucina, Murray, Iain, Worthingon, Joy, Lee, Thomas, Lim, Peik Loon, McLoughlin, James, Macdonald, Christopher, Mairs, Philip, Monk, David, Preston, Sean, Pugh, Stirling, Smart, Howard, Soliman, Ashraf, Isaacs, Peter, Aldulaimi, David, Trudgill, Nigel, Teare, Julian, Benhamida, Abduljalil, Bell, Andrew, Boulton-Jones, Robert, Daneshmend, Tawfique, Suzuki, Hisaharu, Cullen, Sue, Fitzgerald, Rebecca, Ransford, Rupert, Rahman, Mohammad Mesbahur, Tebala, Giovanni Domenico, Hallissey, Michael, Kelly, Carrie, Hickish, Tamas, Taha, Ali, Rademaker, Johan, Whitehead, Mark, Kelly, Sean, Phull, Perminder, Sharma, Naveen, Perry, Ian, Sankara-Raman, Vankatraman, Ali, Haythem, Khan, Iqbal, Curtis, Howard, Wadley, Martin, Stone, Adam, Sukumaran, Sumesh, Higham, Andrew, Lewis, Stephen, Haycock, Adam, Usselmann, Bernhard, Johnston, Simon Douglas, Tham, Tony, Campbell, Stewart, Douds, Andrew, Dunn, Jason, Sargeant, Ian, Narain, Mark, Maynard, Nick, Chilton, Andrew, Green, Susi, Loft, Duncan, Decadt, Bart, Mendall, Michael, Heydtmann, Mathis, Fisher, Neil, Jankowski, Janusz A Z, de Caestecker, John, Love, Sharon B, Reilly, Gavin, Watson, Peter, Sanders, Scott, Ang, Yeng, Morris, Danielle, Bhandari, Pradeep, Brooks, Claire, Attwood, Stephen, Harrison, Rebecca, Barr, Hugh, and Moayyedi, Paul

Published
2018
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10. Learning curves and the influence of procedural volume for the treatment of dysplastic Barrett’s esophagus

Author

Lipman, Gideon, primary, Markar, Sheraz, additional, Gupta, Abhinav, additional, Haidry, Rehan J., additional, Lovat, Laurence B., additional, Novelli, Marco, additional, Banks, Matthew, additional, Sehgal, Vinay, additional, Graham, David, additional, Sweis, Rami, additional, Morris, Danielle, additional, Miah, Haroon, additional, Dunn, Jason M., additional, Smart, Howard L., additional, Bhandari, Pradeep, additional, Smith, Lesley, additional, Willert, Robert, additional, Fullarton, Grant, additional, Morris, John, additional, Di Pietro, Massimiliano, additional, Gordon, Charles, additional, Penman, Ian, additional, Barr, Hugh, additional, Patel, Praful, additional, Boger, Philip, additional, Kapoor, Neil, additional, Hoare, Jonathan, additional, Direkze, Natalie, additional, Ang, Yeng, additional, Veitch, Andrew, additional, Ragunath, Krish, additional, Cheong, Edward, additional, Dhar, Anjan, additional, Nylander, David, additional, Mahon, Brinder, additional, Narayanasamy, Ravi, additional, and O’Toole, Dermot, additional

Published
2020
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13. Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial

Author

Jankowski, Janusz A Z, primary, de Caestecker, John, additional, Love, Sharon B, additional, Reilly, Gavin, additional, Watson, Peter, additional, Sanders, Scott, additional, Ang, Yeng, additional, Morris, Danielle, additional, Bhandari, Pradeep, additional, Brooks, Claire, additional, Attwood, Stephen, additional, Harrison, Rebecca, additional, Barr, Hugh, additional, Moayyedi, Paul, additional, Ragunath, Krish, additional, Rameh, Bashir, additional, Fullarton, Grant, additional, Tucker, Art, additional, Penman, Ian, additional, Rodgers, Colin, additional, Neale, James, additional, Edwards, Cathryn, additional, Wise, Adelyn, additional, Jones, Stephen, additional, Church, Nicholas, additional, Vaidya, Kishor, additional, Balata, Sherzad, additional, Todd, John, additional, Gibbons, Michael, additional, Johnston, David, additional, Anderson, Mark, additional, Davies, Gareth, additional, Dickey, William, additional, Murdock, Andrew, additional, Turner, Graham, additional, Goddard, Andrew, additional, Gore, Stephen, additional, Haigh, Chris, additional, Harding, Timothy, additional, Jackson, Lucina, additional, Murray, Iain, additional, Worthingon, Joy, additional, Lee, Thomas, additional, Lim, Peik Loon, additional, McLoughlin, James, additional, Macdonald, Christopher, additional, Mairs, Philip, additional, Monk, David, additional, Preston, Sean, additional, Pugh, Stirling, additional, Smart, Howard, additional, Soliman, Ashraf, additional, Isaacs, Peter, additional, Aldulaimi, David, additional, Trudgill, Nigel, additional, Teare, Julian, additional, Benhamida, Abduljalil, additional, Bell, Andrew, additional, Boulton-Jones, Robert, additional, Daneshmend, Tawfique, additional, Suzuki, Hisaharu, additional, Cullen, Sue, additional, Fitzgerald, Rebecca, additional, Ransford, Rupert, additional, Rahman, Mohammad Mesbahur, additional, Tebala, Giovanni Domenico, additional, Hallissey, Michael, additional, Kelly, Carrie, additional, Hickish, Tamas, additional, Taha, Ali, additional, Rademaker, Johan, additional, Whitehead, Mark, additional, Kelly, Sean, additional, Phull, Perminder, additional, Sharma, Naveen, additional, Perry, Ian, additional, Sankara-Raman, Vankatraman, additional, Ali, Haythem, additional, Khan, Iqbal, additional, Curtis, Howard, additional, Wadley, Martin, additional, Stone, Adam, additional, Sukumaran, Sumesh, additional, Higham, Andrew, additional, Lewis, Stephen, additional, Haycock, Adam, additional, Usselmann, Bernhard, additional, Johnston, Simon Douglas, additional, Tham, Tony, additional, Campbell, Stewart, additional, Douds, Andrew, additional, Dunn, Jason, additional, Sargeant, Ian, additional, Narain, Mark, additional, Maynard, Nick, additional, Chilton, Andrew, additional, Green, Susi, additional, Loft, Duncan, additional, Decadt, Bart, additional, Mendall, Michael, additional, Heydtmann, Mathis, additional, and Fisher, Neil, additional

Published
2018
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14. 481 LONG-TERM FOLLOW-UP RESULTS OF A RANDOMIZED TRIAL COMPARING RADIOFREQUENCY ABLATION VERSUS ENDOSCOPIC SURVEILLANCE IN BARRETT'S ESOPHAGUS PATIENTS WITH LOW-GRADE DYSPLASIA

Author

Klaver, Esther, primary, Phoa, K. Nadine, additional, van Vilsteren, Frederike G., additional, Weusten, Bas L., additional, Bisschops, Raf, additional, Schoon, Erik. J., additional, Pech, Oliver, additional, Manner, Hendrik, additional, Ragunath, Krish, additional, Fernández-Sordo, Jacobo Ortiz, additional, Fullarton, Grant, additional, Di Pietro, Massimiliano, additional, Januszewicz, Wladyslaw, additional, Narayanasamy, Ravi, additional, O'Toole, Dermot, additional, Bergman, Jacques, additional, and Pouw, Roos E., additional

Published
2018
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16. 841 Residual Intestinal Metaplasia After Successful Endoscopic Therapy for Barrett's Related Neoplasia Confers Higher Long Term Risk for Disease Recurrence, on Behalf of the UK RFA Registry

Author

Lipman, Gideon, primary, Gupta, Abhinav, additional, Banks, Matthew, additional, Sweis, Rami, additional, Dunn, Jason M., additional, Miah, Haroon, additional, Morris, Danielle, additional, Smart, Howard, additional, Bhandari, Pradeep, additional, Willert, Robert P., additional, Fullarton, Grant, additional, Morris, Allan J., additional, Pietro, Massimiliano Di, additional, Mundre, Pradeep, additional, Gordon, Charles, additional, Penman, Ian, additional, Barr, Hugh, additional, Patel, Praful, additional, Boger, Philip, additional, Kapoor, Neil, additional, Mahon, Brinder S., additional, Hoare, Jonathan, additional, Narayanasamy, Ravi, additional, O'Toole, Dermot, additional, Direkze, Natalie, additional, Ang, Yeng, additional, Veitch, Andrew, additional, Nylander, David, additional, Dhar, Anjan, additional, Ragunath, Krish, additional, Leahy, Anthony, additional, Fullard, Mark, additional, Haidry, Rehan, additional, and Lovat, Laurence, additional

Published
2016
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17. Reply to Kristo et al.

Author

Haidry, Rehan, additional, Lipman, Gideon, additional, Banks, Matthew, additional, Butt, Mohammed, additional, Sehgal, Vinay, additional, Graham, David, additional, Dunn, Jason, additional, Gupta, Abhinav, additional, Sweis, Rami, additional, Miah, Haroon, additional, Morris, Danielle, additional, Smart, Howard, additional, Bhandari, Pradeep, additional, Willert, Robert, additional, Fullarton, Grant, additional, Morris, Jonathon, additional, Di Pietro, Massimo, additional, Gordon, Charles, additional, Penman, Ian, additional, Barr, High, additional, Patel, Praful, additional, Boger, Philip, additional, Kapoor, Neil, additional, Mahon, Brinder, additional, Hoare, Jonathon, additional, Narayanasamy, Ravi, additional, O’Toole, Dermot, additional, Cheong, Edward, additional, Direkze, Natalie, additional, Ang, Yeng, additional, Veitch, Andrew, additional, Dhar, Anjan, additional, Nyalender, David, additional, Ragunath, Krish, additional, Leahy, Anthony, additional, Fullard, Mark, additional, Rodriguez-Justo, Manuel, additional, Novelli, Marco, additional, and Lovat, Laurence, additional

Published
2015
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18. Comparing outcome of radiofrequency ablation in Barrett’s with high grade dysplasia and intramucosal carcinoma: a prospective multicenter UK registry

Author

Haidry, Rehan, additional, Lipman, Gideon, additional, Banks, Matthew, additional, Butt, Mohammed, additional, Sehgal, Vinay, additional, Graham, David, additional, Dunn, Jason, additional, Gupta, Abhinav, additional, Sweis, Rami, additional, Miah, Haroon, additional, Morris, Danielle, additional, Smart, Howard, additional, Bhandari, Pradeep, additional, Willert, Robert, additional, Fullarton, Grant, additional, Morris, Jonathon, additional, Di Pietro, Massimo, additional, Gordon, Charles, additional, Penman, Ian, additional, Barr, High, additional, Patel, Praful, additional, Boger, Philip, additional, Kapoor, Neil, additional, Mahon, Brinder, additional, Hoare, Jonathon, additional, Narayanasamy, Ravi, additional, O’Toole, Dermot, additional, Cheong, Edward, additional, Direkze, Natalie, additional, Ang, Yeng, additional, Veitch, Andrew, additional, Dhar, Anjan, additional, Nyalender, David, additional, Ragunath, Krish, additional, Leahy, Anthony, additional, Fullard, Mark, additional, Rodriguez-Justo, Manuel, additional, Novelli, Marco, additional, and Lovat, Laurence, additional

Published
2015
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20. Sa1081 Outcomes of Patients Who Fail Initial Endoscopic Therapy for Barrett's Related Neoplasia

Author

Haidry, Rehan J., primary, Lipman, Gideon, additional, Butt, Mohammed A., additional, Gupta, Abhinav, additional, Sweis, Rami, additional, Dunn, Jason M., additional, Smart, Howard, additional, Bhandari, Pradeep, additional, Willert, Robert P., additional, Fullarton, Grant, additional, Morris, Jonathon, additional, di Pietro, Massimiliano, additional, Gordon, Charles, additional, Penman, Ian D., additional, Barr, Hugh, additional, Boger, Philip C., additional, Kapoor, Neil, additional, Mahon, Brinder S., additional, Hoare, Jonathan M., additional, Ravi, Narayanasamy, additional, O'Toole, Dermot, additional, Ang, Yeng, additional, Rodriguez-Justo, Manuel, additional, Novelli, Marco, additional, Banks, Matthew R., additional, and Lovat, Laurence, additional

Published
2015
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21. 53 Six Year Disease Durability Outcomes on Patients Treated With Endoscopic Therapy for Barrett's Related Neoplasia From the UK Registry

Author

Haidry, Rehan J., primary, Lipman, Gideon, additional, Butt, Mohammed A., additional, Gupta, Abhinav, additional, Sweis, Rami, additional, Dunn, Jason M., additional, Smart, Howard, additional, Bhandari, Pradeep, additional, Willert, Robert P., additional, Fullarton, Grant, additional, Morris, Jonathon, additional, di Pietro, Massimiliano, additional, Gordon, Charles, additional, Penman, Ian D., additional, Barr, Hugh, additional, Boger, Philip C., additional, Kapoor, Neil, additional, Mahon, Brinder S., additional, Hoare, Jonathan M., additional, Ravi, Narayanasamy, additional, O'Toole, Dermot, additional, Ang, Yeng, additional, Rodriguez-Justo, Manuel, additional, Novelli, Marco, additional, Banks, Matthew R., additional, and Lovat, Laurence, additional

Published
2015
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23. Endoscopic removal of an eroded magnetic sphincter augmentation device.

Author

Po Man Yeung, Baldwin, Fullarton, Grant, and Yeung, Baldwin Po Man

Subjects
*ARTIFICIAL sphincters, *MEDICAL device removal, *ENDOSCOPIC surgery, *ESOPHAGEAL surgery, *CHEST pain, *DEGLUTITION disorders, *GASTROESOPHAGEAL reflux, *MAGNETS, *COMPLICATIONS of prosthesis, *ENDOSCOPIC gastrointestinal surgery, *EQUIPMENT & supplies
Abstract

The article discusses a study of a 57-year-old man who required a magnetic sphincter augmentation with the aid of LINX device for treating gastroesophageal reflux disease (GERD) and then had the device removed with the aid of an endoscopic surgery as it got eroded in course of time.

Published
2017
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24. Reply to Kristo et al.

Author

Haidry, Rehan J., Lipman, Gideon, R. Banks, Matthew, Butt, Mohammed A., Sehgal, Vinay, Graham, David, Dunn, Jason M., Gupta, Abhinav, Sweis, Rami, Miah, Haroon, Morris, Danielle, Smart, Howard L., Bhandari, Pradeep, Willert, Robert, Fullarton, Grant, Morris, Jonathon, Di Pietro, Massimo, Gordon, Charles, Penman, Ian, and Barr, High

Subjects
ESOPHAGEAL surgery, ADENOCARCINOMA, CATHETER ablation, ESOPHAGEAL tumors, PRECANCEROUS conditions, BARRETT'S esophagus
Abstract

A response from the author of an article on the role of surgical treatment for acid reflux in maintaining long term disease remission after successful endoscopic therapy in a previous issue is presented.

Published
2016
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