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205 results on '"Fukuda, Shiro"'

7. Food Preference Assessed by the Newly Developed Nutrition-Based Japan Food Preference Questionnaire and Its Association with Dietary Intake in Abdominal-Obese Subjects.

Author

Nagai, Naoko, Fujishima, Yuya, Tokuzawa, Chie, Takayanagi, Satoko, Yamamoto, Mikiko, Hara, Tomoyuki, Kimura, Yu, Nagao, Hirofumi, Obata, Yoshinari, Fukuda, Shiro, Baden, Megu Y., Kozawa, Junji, Maeda, Norikazu, Nishizawa, Hitoshi, and Shimomura, Iichiro

Abstract

Background/Objectives: Understanding food preferences is important for weight management. However, methods for assessing food preferences are not well established, especially in Japan. This study aimed to examine detailed food preferences and their associations with actual food intake in non-obese and abdominal-obese subjects using a newly developed questionnaire tailored for the Japanese population. Methods: We developed the Japan Food Preference Questionnaire (JFPQ) to evaluate food preferences across four nutrient groups based on nutritional evidence: carbohydrate, fat, protein, and dietary fiber. A total of 38 non-obese and 30 abdominal-obese participants completed both the JFPQ and the Food Frequency Questionnaire (FFQ). Food preferences for each nutrient were compared between the two groups, and correlations between food preferences (assessed by the JFPQ) and food intake (assessed by the FFQ) were analyzed. Results: Compared with the non-obese group, the abdominal-obese group showed significantly greater preferences for carbohydrates, fat, and protein, with no significant difference in dietary fiber after adjusting for age and sex. Furthermore, in the abdominal-obese group, positive correlations were found between actual intake and preference for high-fat and high-carbohydrate foods. Conclusions: Our findings from this pilot study demonstrated that abdominal-obese individuals had greater preferences for fat and carbohydrates, which were linked to actual fat and carbohydrate intake and possibly contributed to the development of obesity. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia

Author

Isobe, Tomoya, Takagi, Masatoshi, Sato-Otsubo, Aiko, Nishimura, Akira, Nagae, Genta, Yamagishi, Chika, Tamura, Moe, Tanaka, Yosuke, Asada, Shuhei, Takeda, Reina, Tsuchiya, Akiho, Wang, Xiaonan, Yoshida, Kenichi, Nannya, Yasuhito, Ueno, Hiroo, Akazawa, Ryo, Kato, Itaru, Mikami, Takashi, Watanabe, Kentaro, Sekiguchi, Masahiro, Seki, Masafumi, Kimura, Shunsuke, Hiwatari, Mitsuteru, Kato, Motohiro, Fukuda, Shiro, Tatsuno, Kenji, Tsutsumi, Shuichi, Kanai, Akinori, Inaba, Toshiya, Shiozawa, Yusuke, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Kotecha, Rishi S., Cruickshank, Mark N., Ishikawa, Fumihiko, Morio, Tomohiro, Eguchi, Mariko, Deguchi, Takao, Kiyokawa, Nobutaka, Arakawa, Yuki, Koh, Katsuyoshi, Aoki, Yuki, Ishihara, Takashi, Tomizawa, Daisuke, Miyamura, Takako, Ishii, Eiichi, Mizutani, Shuki, Wilson, Nicola K., Göttgens, Berthold, Miyano, Satoru, Kitamura, Toshio, Goyama, Susumu, Yokoyama, Akihiko, Aburatani, Hiroyuki, Ogawa, Seishi, and Takita, Junko

Published
2022
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11. Region‐specific DNA hydroxymethylation along the malignant progression of IDH‐mutant gliomas

Author

Hana, Taijun, primary, Mukasa, Akitake, additional, Nomura, Masashi, additional, Nagae, Genta, additional, Yamamoto, Shogo, additional, Tatsuno, Kenji, additional, Ueda, Hiroki, additional, Fukuda, Shiro, additional, Umeda, Takayoshi, additional, Tanaka, Shota, additional, Nejo, Takahide, additional, Kitagawa, Yosuke, additional, Yamazawa, Erika, additional, Takahashi, Satoshi, additional, Koike, Tsukasa, additional, Kushihara, Yoshihiro, additional, Takami, Hirokazu, additional, Takayanagi, Shunsaku, additional, Aburatani, Hiroyuki, additional, and Saito, Nobuhito, additional

Published
2024
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12. Genetic and epigenetic basis of hepatoblastoma diversity

Author

Nagae, Genta, Yamamoto, Shogo, Fujita, Masashi, Fujita, Takanori, Nonaka, Aya, Umeda, Takayoshi, Fukuda, Shiro, Tatsuno, Kenji, Maejima, Kazuhiro, Hayashi, Akimasa, Kurihara, Sho, Kojima, Masato, Hishiki, Tomoro, Watanabe, Kenichiro, Ida, Kohmei, Yano, Michihiro, Hiyama, Yoko, Tanaka, Yukichi, Inoue, Takeshi, Ueda, Hiroki, Nakagawa, Hidewaki, Aburatani, Hiroyuki, and Hiyama, Eiso

Published
2021
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17. Publisher Correction: DNA demethylation is associated with malignant progression of lower-grade gliomas

Author

Nomura, Masashi, Saito, Kuniaki, Aihara, Koki, Nagae, Genta, Yamamoto, Shogo, Tatsuno, Kenji, Ueda, Hiroki, Fukuda, Shiro, Umeda, Takayoshi, Tanaka, Shota, Takayanagi, Shunsaku, Otani, Ryohei, Nejo, Takahide, Hana, Taijun, Takahashi, Satoshi, Kitagawa, Yosuke, Omata, Mayu, Higuchi, Fumi, Nakamura, Taishi, Muragaki, Yoshihiro, Narita, Yoshitaka, Nagane, Motoo, Nishikawa, Ryo, Ueki, Keisuke, Saito, Nobuhito, Aburatani, Hiroyuki, and Mukasa, Akitake

Published
2019
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18. Cerebrovascular CO.sub.2 reactivity during isoflurane-nitrous oxide anesthesia in patients with chronic renal failure

Author

Ishida, Kazuyoshi, Uchida, Masato, Utada, Kohji, Yamashita, Atsuo, Yamashita, Satoshi, Fukuda, Shiro, and Matsumoto, Mishiya

Subjects
Care and treatment, Analysis, Risk factors, Patient outcomes, Health aspects, Isoflurane -- Health aspects -- Analysis, Nitrous oxide -- Health aspects -- Analysis, Cerebrovascular disorders -- Analysis -- Risk factors, Chronic kidney failure -- Care and treatment -- Patient outcomes -- Analysis
Abstract

Author(s): Kazuyoshi Ishida [sup.1] , Masato Uchida [sup.1] , Kohji Utada [sup.1] , Atsuo Yamashita [sup.1] , Satoshi Yamashita [sup.1] , Shiro Fukuda [sup.1] , Mishiya Matsumoto [sup.1] , Takefumi [...], Purpose We assessed the cerebrovascular CO.sub.2 reactivity (CO.sub.2R) in chronic renal failure (CRF) patients without diabetes mellitus (DM), uncontrolled hypertension, peripheral vascular disease, or neurological disease under isoflurane-nitrous oxide anesthesia. Methods Forty-nine patients undergoing surgery, including 36 CRF patients (30 receiving dialysis and six pre-dialysis patients) and 13 patients without CRF (controls). Middle cerebral artery flow velocity (VMCA) was measured by transcranial Doppler ultrasonography at an end-tidal CO.sub.2 of 35 to 45 mmHg. CO.sub.2R was calculated as an absolute value (change in VMCA per mmHg PaCO.sub.2) and a relative value (absolute CO.sub.2R/baseline VMCA x 100). Factors associated with CO.sub.2R were evaluated simultaneously. Results Despite no significant differences in the absolute and relative values of CO.sub.2R between the CRF (mean 2.5 cm/s/mmHg; median 5.0%/mmHg) and control (2.4 cm/s/mmHg; 5.0%/mmHg) groups, blood urea nitrogen (BUN) concentrations in the CRF group correlated inversely with both absolute and relative CO.sub.2R. BUN concentration was higher (mean 72 versus 53 mg/dl, p = 0.006) and relative CO.sub.2R was lower (mean 2.6 versus 5.7%/mmHg, p = 0.011) in patients with pre-dialysis CRF (n = 6) versus CRF patients receiving dialysis (n = 30). Conclusions CO.sub.2R in CRF patients was not significantly different from that in controls. However, in CRF patients with high BUN concentrations, CO.sub.2R might be impaired, leading to reduced cerebrovascular reserve capacity. Because DM is a major cause of CRF and we excluded DM patients, our results might not be applicable to patients with DM-induced CRF.

Published
2018
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19. Table S6 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma

Author

Hmeljak, Julija, primary, Sanchez-Vega, Francisco, primary, Hoadley, Katherine A., primary, Shih, Juliann, primary, Stewart, Chip, primary, Heiman, David, primary, Tarpey, Patrick, primary, Danilova, Ludmila, primary, Drill, Esther, primary, Gibb, Ewan A., primary, Bowlby, Reanne, primary, Kanchi, Rupa, primary, Osmanbeyoglu, Hatice U., primary, Sekido, Yoshitaka, primary, Takeshita, Jumpei, primary, Newton, Yulia, primary, Graim, Kiley, primary, Gupta, Manaswi, primary, Gay, Carl M., primary, Diao, Lixia, primary, Gibbs, David L., primary, Thorsson, Vesteinn, primary, Iype, Lisa, primary, Kantheti, Havish, primary, Severson, David T., primary, Ravegnini, Gloria, primary, Desmeules, Patrice, primary, Jungbluth, Achim A., primary, Travis, William D., primary, Dacic, Sanja, primary, Chirieac, Lucian R., primary, Galateau-Sallé, Françoise, primary, Fujimoto, Junya, primary, Husain, Aliya N., primary, Silveira, Henrique C., primary, Rusch, Valerie W., primary, Rintoul, Robert C., primary, Pass, Harvey, primary, Kindler, Hedy, primary, Zauderer, Marjorie G., primary, Kwiatkowski, David J., primary, Bueno, Raphael, primary, Tsao, Anne S., primary, Creaney, Jenette, primary, Lichtenberg, Tara, primary, Leraas, Kristen, primary, Bowen, Jay, primary, Felau, Ina, primary, Zenklusen, Jean Claude, primary, Akbani, Rehan, primary, Cherniack, Andrew D., primary, Byers, Lauren A., primary, Noble, Michael S., primary, Fletcher, Jonathan A., primary, Robertson, A. Gordon, primary, Shen, Ronglai, primary, Aburatani, Hiroyuki, primary, Robinson, Bruce W., primary, Campbell, Peter, primary, Ladanyi, Marc, primary, Ally, Adrian, primary, Anur, Pavana, primary, Armenia, Joshua, primary, Auman, J. Todd, primary, Balasundaram, Miruna, primary, Balu, Saianand, primary, Baylin, Stephen B., primary, Becich, Michael, primary, Behrens, Carmen, primary, Beroukhim, Rameen, primary, Bielski, Craig, primary, Bodenheimer, Tom, primary, Bootwalla, Moiz S., primary, Brooks, Denise, primary, Byers, Lauren Averett, primary, Cárcano, Flávio M., primary, Carlsen, Rebecca, primary, Carvalho, Andre L., primary, Cheung, Dorothy, primary, Chirieac, Lucian, primary, Cho, Juok, primary, Chuah, Eric, primary, Chudamani, Sudha, primary, Cibulskis, Carrie, primary, Cope, Leslie, primary, Crain, Daniel, primary, Curley, Erin, primary, Rienzo, Assunta De, primary, DeFreitas, Timothy, primary, Demchok, John A., primary, Dhalla, Noreen, primary, Dhir, Rajiv, primary, Feldman, Michael, primary, Ferguson, Martin L., primary, Fukuda, Shiro, primary, Gabriel, Stacey B., primary, Sallé, Françoise Galateau, primary, Gao, Jianjiong, primary, Gardner, Johanna, primary, Gastier-Foster, Julie M., primary, Gehlenborg, Nils, primary, Gerken, Mark, primary, Getz, Gad, primary, Goparaju, Chandra, primary, Gross, Benjamin, primary, Guo, Guangwu, primary, Hasegawa, Seiki, primary, Haussler, David, primary, Hayes, D. Neil, primary, Heiman, David I., primary, Heins, Zachary, primary, Holt, Robert A., primary, Hoyle, Alan P., primary, Husain, Aliya, primary, Hutter, Carolyn M., primary, Jefferys, Stuart R., primary, Jones, Steven J.M., primary, Jones, Corbin D., primary, Kanchi, Rupa S., primary, Kasaian, Katayoon, primary, Kim, Jaegil, primary, Kondo, Nobuyuki, primary, Krausz, Thomas, primary, Kundra, Ritika, primary, Kuribayashi, Kozo, primary, Lai, Phillip H., primary, Laird, Peter W., primary, Lawrence, Michael S., primary, Lee, Darlene, primary, Leraas, Kristen M., primary, Lichtenberg, Tara M., primary, Lin, Pei, primary, Liu, Jia, primary, Liu, Wenbin, primary, Liu, Eric Minwei, primary, Lolla, Laxmi, primary, Longatto-Filho, Adhemar, primary, Lu, Yiling, primary, Luketich, James, primary, Ma, Yussanne, primary, Maglinte, Dennis T., primary, Mallory, David, primary, Marra, Marco A., primary, Mayo, Michael, primary, Meier, Sam, primary, Melamed, Jonathan, primary, Meng, Shaowu, primary, Meyerson, Matthew, primary, Mieczkowski, Piotr A., primary, Mills, Gordon B., primary, Moore, Richard A., primary, Moran, Cesar, primary, Morris, Scott, primary, Mose, Lisle E., primary, Mungall, Andrew J., primary, Mungall, Karen, primary, Nakano, Takashi, primary, Naresh, Rashi, primary, Ochoa, Angelica, primary, Osmanbeyoglu, Hatice, primary, Parker, Joel S., primary, Pass, Harvey I., primary, Paulauskis, Joseph, primary, Pennathur, Arjun, primary, Pennell, Nathan A., primary, Penny, Robert, primary, Perou, Charles M., primary, Pihl, Todd, primary, Ramirez, Nilsa C., primary, Rassl, Doris M., primary, Reid, Glen, primary, Reis, Rui M., primary, Reynolds, Sheila M., primary, Rice, David, primary, Richards, William G, primary, Roach, Jeffrey, primary, Rusch, Valerie, primary, Sadeghi, Sara, primary, Saksena, Gordon, primary, Sander, Chris, primary, Sato, Ayuko, primary, Scapulatempo-Neto, Cristovam, primary, Schein, Jacqueline E., primary, Schultz, Nikolaus, primary, Schumacher, Steven E., primary, Seiwert, Tanguy, primary, Severson, David T, primary, Shelton, Candace, primary, Shelton, Troy, primary, Sheridan, Robert, primary, Shi, Yan, primary, Shiraishi, Yuichi, primary, Shmulevich, Ilya, primary, Silveira, Henrique C. S., primary, Simons, Janae V., primary, Sipahimalani, Payal, primary, Skelly, Tara, primary, Sofia, Heidi J., primary, Soloway, Matthew G., primary, Spellman, Paul, primary, Stuart, Josh, primary, Sun, Qiang, primary, Tam, Angela, primary, Tan, Donghui, primary, Tarnuzzer, Roy, primary, Tatsuno, Kenji, primary, Taylor, Barry S, primary, Thiessen, Nina, primary, Thompson, Eric, primary, Tsao, Anne, primary, Tse, Kane, primary, Tsujimura, Tohru, primary, Valdivieso, Federico, primary, Van Den Berg, David J., primary, van Zandwijk, Nico, primary, Veluvolu, Umadevi, primary, Viana, Luciano S., primary, Voet, Douglas, primary, Wan, Yunhu, primary, Wang, Zhining, primary, Wang, Jing, primary, Weaver, Joellen, primary, Weinstein, John N., primary, Weisenberger, Daniel J., primary, Wilkerson, Matthew D., primary, Wise, Lisa, primary, Wistuba, Ignacio, primary, Wong, Tina, primary, Wu, Ye, primary, Yamamoto, Shogo, primary, Yang, Liming, primary, Zenklusen, Jean C., primary, Zhang, Jiashan, primary, Zhang, Hailei, primary, Zhang, Hongxin, primary, and Zmuda, Erik, primary

Published
2023
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20. Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma

Author

Hmeljak, Julija, primary, Sanchez-Vega, Francisco, primary, Hoadley, Katherine A., primary, Shih, Juliann, primary, Stewart, Chip, primary, Heiman, David, primary, Tarpey, Patrick, primary, Danilova, Ludmila, primary, Drill, Esther, primary, Gibb, Ewan A., primary, Bowlby, Reanne, primary, Kanchi, Rupa, primary, Osmanbeyoglu, Hatice U., primary, Sekido, Yoshitaka, primary, Takeshita, Jumpei, primary, Newton, Yulia, primary, Graim, Kiley, primary, Gupta, Manaswi, primary, Gay, Carl M., primary, Diao, Lixia, primary, Gibbs, David L., primary, Thorsson, Vesteinn, primary, Iype, Lisa, primary, Kantheti, Havish, primary, Severson, David T., primary, Ravegnini, Gloria, primary, Desmeules, Patrice, primary, Jungbluth, Achim A., primary, Travis, William D., primary, Dacic, Sanja, primary, Chirieac, Lucian R., primary, Galateau-Sallé, Françoise, primary, Fujimoto, Junya, primary, Husain, Aliya N., primary, Silveira, Henrique C., primary, Rusch, Valerie W., primary, Rintoul, Robert C., primary, Pass, Harvey, primary, Kindler, Hedy, primary, Zauderer, Marjorie G., primary, Kwiatkowski, David J., primary, Bueno, Raphael, primary, Tsao, Anne S., primary, Creaney, Jenette, primary, Lichtenberg, Tara, primary, Leraas, Kristen, primary, Bowen, Jay, primary, Felau, Ina, primary, Zenklusen, Jean Claude, primary, Akbani, Rehan, primary, Cherniack, Andrew D., primary, Byers, Lauren A., primary, Noble, Michael S., primary, Fletcher, Jonathan A., primary, Robertson, A. Gordon, primary, Shen, Ronglai, primary, Aburatani, Hiroyuki, primary, Robinson, Bruce W., primary, Campbell, Peter, primary, Ladanyi, Marc, primary, Ally, Adrian, primary, Anur, Pavana, primary, Armenia, Joshua, primary, Auman, J. Todd, primary, Balasundaram, Miruna, primary, Balu, Saianand, primary, Baylin, Stephen B., primary, Becich, Michael, primary, Behrens, Carmen, primary, Beroukhim, Rameen, primary, Bielski, Craig, primary, Bodenheimer, Tom, primary, Bootwalla, Moiz S., primary, Brooks, Denise, primary, Byers, Lauren Averett, primary, Cárcano, Flávio M., primary, Carlsen, Rebecca, primary, Carvalho, Andre L., primary, Cheung, Dorothy, primary, Chirieac, Lucian, primary, Cho, Juok, primary, Chuah, Eric, primary, Chudamani, Sudha, primary, Cibulskis, Carrie, primary, Cope, Leslie, primary, Crain, Daniel, primary, Curley, Erin, primary, Rienzo, Assunta De, primary, DeFreitas, Timothy, primary, Demchok, John A., primary, Dhalla, Noreen, primary, Dhir, Rajiv, primary, Feldman, Michael, primary, Ferguson, Martin L., primary, Fukuda, Shiro, primary, Gabriel, Stacey B., primary, Sallé, Françoise Galateau, primary, Gao, Jianjiong, primary, Gardner, Johanna, primary, Gastier-Foster, Julie M., primary, Gehlenborg, Nils, primary, Gerken, Mark, primary, Getz, Gad, primary, Goparaju, Chandra, primary, Gross, Benjamin, primary, Guo, Guangwu, primary, Hasegawa, Seiki, primary, Haussler, David, primary, Hayes, D. Neil, primary, Heiman, David I., primary, Heins, Zachary, primary, Holt, Robert A., primary, Hoyle, Alan P., primary, Husain, Aliya, primary, Hutter, Carolyn M., primary, Jefferys, Stuart R., primary, Jones, Steven J.M., primary, Jones, Corbin D., primary, Kanchi, Rupa S., primary, Kasaian, Katayoon, primary, Kim, Jaegil, primary, Kondo, Nobuyuki, primary, Krausz, Thomas, primary, Kundra, Ritika, primary, Kuribayashi, Kozo, primary, Lai, Phillip H., primary, Laird, Peter W., primary, Lawrence, Michael S., primary, Lee, Darlene, primary, Leraas, Kristen M., primary, Lichtenberg, Tara M., primary, Lin, Pei, primary, Liu, Jia, primary, Liu, Wenbin, primary, Liu, Eric Minwei, primary, Lolla, Laxmi, primary, Longatto-Filho, Adhemar, primary, Lu, Yiling, primary, Luketich, James, primary, Ma, Yussanne, primary, Maglinte, Dennis T., primary, Mallory, David, primary, Marra, Marco A., primary, Mayo, Michael, primary, Meier, Sam, primary, Melamed, Jonathan, primary, Meng, Shaowu, primary, Meyerson, Matthew, primary, Mieczkowski, Piotr A., primary, Mills, Gordon B., primary, Moore, Richard A., primary, Moran, Cesar, primary, Morris, Scott, primary, Mose, Lisle E., primary, Mungall, Andrew J., primary, Mungall, Karen, primary, Nakano, Takashi, primary, Naresh, Rashi, primary, Ochoa, Angelica, primary, Osmanbeyoglu, Hatice, primary, Parker, Joel S., primary, Pass, Harvey I., primary, Paulauskis, Joseph, primary, Pennathur, Arjun, primary, Pennell, Nathan A., primary, Penny, Robert, primary, Perou, Charles M., primary, Pihl, Todd, primary, Ramirez, Nilsa C., primary, Rassl, Doris M., primary, Reid, Glen, primary, Reis, Rui M., primary, Reynolds, Sheila M., primary, Rice, David, primary, Richards, William G, primary, Roach, Jeffrey, primary, Rusch, Valerie, primary, Sadeghi, Sara, primary, Saksena, Gordon, primary, Sander, Chris, primary, Sato, Ayuko, primary, Scapulatempo-Neto, Cristovam, primary, Schein, Jacqueline E., primary, Schultz, Nikolaus, primary, Schumacher, Steven E., primary, Seiwert, Tanguy, primary, Severson, David T, primary, Shelton, Candace, primary, Shelton, Troy, primary, Sheridan, Robert, primary, Shi, Yan, primary, Shiraishi, Yuichi, primary, Shmulevich, Ilya, primary, Silveira, Henrique C. S., primary, Simons, Janae V., primary, Sipahimalani, Payal, primary, Skelly, Tara, primary, Sofia, Heidi J., primary, Soloway, Matthew G., primary, Spellman, Paul, primary, Stuart, Josh, primary, Sun, Qiang, primary, Tam, Angela, primary, Tan, Donghui, primary, Tarnuzzer, Roy, primary, Tatsuno, Kenji, primary, Taylor, Barry S, primary, Thiessen, Nina, primary, Thompson, Eric, primary, Tsao, Anne, primary, Tse, Kane, primary, Tsujimura, Tohru, primary, Valdivieso, Federico, primary, Van Den Berg, David J., primary, van Zandwijk, Nico, primary, Veluvolu, Umadevi, primary, Viana, Luciano S., primary, Voet, Douglas, primary, Wan, Yunhu, primary, Wang, Zhining, primary, Wang, Jing, primary, Weaver, Joellen, primary, Weinstein, John N., primary, Weisenberger, Daniel J., primary, Wilkerson, Matthew D., primary, Wise, Lisa, primary, Wistuba, Ignacio, primary, Wong, Tina, primary, Wu, Ye, primary, Yamamoto, Shogo, primary, Yang, Liming, primary, Zenklusen, Jean C., primary, Zhang, Jiashan, primary, Zhang, Hailei, primary, Zhang, Hongxin, primary, and Zmuda, Erik, primary

Published
2023
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21. Supplementary Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma

Author

Hmeljak, Julija, primary, Sanchez-Vega, Francisco, primary, Hoadley, Katherine A., primary, Shih, Juliann, primary, Stewart, Chip, primary, Heiman, David, primary, Tarpey, Patrick, primary, Danilova, Ludmila, primary, Drill, Esther, primary, Gibb, Ewan A., primary, Bowlby, Reanne, primary, Kanchi, Rupa, primary, Osmanbeyoglu, Hatice U., primary, Sekido, Yoshitaka, primary, Takeshita, Jumpei, primary, Newton, Yulia, primary, Graim, Kiley, primary, Gupta, Manaswi, primary, Gay, Carl M., primary, Diao, Lixia, primary, Gibbs, David L., primary, Thorsson, Vesteinn, primary, Iype, Lisa, primary, Kantheti, Havish, primary, Severson, David T., primary, Ravegnini, Gloria, primary, Desmeules, Patrice, primary, Jungbluth, Achim A., primary, Travis, William D., primary, Dacic, Sanja, primary, Chirieac, Lucian R., primary, Galateau-Sallé, Françoise, primary, Fujimoto, Junya, primary, Husain, Aliya N., primary, Silveira, Henrique C., primary, Rusch, Valerie W., primary, Rintoul, Robert C., primary, Pass, Harvey, primary, Kindler, Hedy, primary, Zauderer, Marjorie G., primary, Kwiatkowski, David J., primary, Bueno, Raphael, primary, Tsao, Anne S., primary, Creaney, Jenette, primary, Lichtenberg, Tara, primary, Leraas, Kristen, primary, Bowen, Jay, primary, Felau, Ina, primary, Zenklusen, Jean Claude, primary, Akbani, Rehan, primary, Cherniack, Andrew D., primary, Byers, Lauren A., primary, Noble, Michael S., primary, Fletcher, Jonathan A., primary, Robertson, A. Gordon, primary, Shen, Ronglai, primary, Aburatani, Hiroyuki, primary, Robinson, Bruce W., primary, Campbell, Peter, primary, Ladanyi, Marc, primary, Ally, Adrian, primary, Anur, Pavana, primary, Armenia, Joshua, primary, Auman, J. Todd, primary, Balasundaram, Miruna, primary, Balu, Saianand, primary, Baylin, Stephen B., primary, Becich, Michael, primary, Behrens, Carmen, primary, Beroukhim, Rameen, primary, Bielski, Craig, primary, Bodenheimer, Tom, primary, Bootwalla, Moiz S., primary, Brooks, Denise, primary, Byers, Lauren Averett, primary, Cárcano, Flávio M., primary, Carlsen, Rebecca, primary, Carvalho, Andre L., primary, Cheung, Dorothy, primary, Chirieac, Lucian, primary, Cho, Juok, primary, Chuah, Eric, primary, Chudamani, Sudha, primary, Cibulskis, Carrie, primary, Cope, Leslie, primary, Crain, Daniel, primary, Curley, Erin, primary, Rienzo, Assunta De, primary, DeFreitas, Timothy, primary, Demchok, John A., primary, Dhalla, Noreen, primary, Dhir, Rajiv, primary, Feldman, Michael, primary, Ferguson, Martin L., primary, Fukuda, Shiro, primary, Gabriel, Stacey B., primary, Sallé, Françoise Galateau, primary, Gao, Jianjiong, primary, Gardner, Johanna, primary, Gastier-Foster, Julie M., primary, Gehlenborg, Nils, primary, Gerken, Mark, primary, Getz, Gad, primary, Goparaju, Chandra, primary, Gross, Benjamin, primary, Guo, Guangwu, primary, Hasegawa, Seiki, primary, Haussler, David, primary, Hayes, D. Neil, primary, Heiman, David I., primary, Heins, Zachary, primary, Holt, Robert A., primary, Hoyle, Alan P., primary, Husain, Aliya, primary, Hutter, Carolyn M., primary, Jefferys, Stuart R., primary, Jones, Steven J.M., primary, Jones, Corbin D., primary, Kanchi, Rupa S., primary, Kasaian, Katayoon, primary, Kim, Jaegil, primary, Kondo, Nobuyuki, primary, Krausz, Thomas, primary, Kundra, Ritika, primary, Kuribayashi, Kozo, primary, Lai, Phillip H., primary, Laird, Peter W., primary, Lawrence, Michael S., primary, Lee, Darlene, primary, Leraas, Kristen M., primary, Lichtenberg, Tara M., primary, Lin, Pei, primary, Liu, Jia, primary, Liu, Wenbin, primary, Liu, Eric Minwei, primary, Lolla, Laxmi, primary, Longatto-Filho, Adhemar, primary, Lu, Yiling, primary, Luketich, James, primary, Ma, Yussanne, primary, Maglinte, Dennis T., primary, Mallory, David, primary, Marra, Marco A., primary, Mayo, Michael, primary, Meier, Sam, primary, Melamed, Jonathan, primary, Meng, Shaowu, primary, Meyerson, Matthew, primary, Mieczkowski, Piotr A., primary, Mills, Gordon B., primary, Moore, Richard A., primary, Moran, Cesar, primary, Morris, Scott, primary, Mose, Lisle E., primary, Mungall, Andrew J., primary, Mungall, Karen, primary, Nakano, Takashi, primary, Naresh, Rashi, primary, Ochoa, Angelica, primary, Osmanbeyoglu, Hatice, primary, Parker, Joel S., primary, Pass, Harvey I., primary, Paulauskis, Joseph, primary, Pennathur, Arjun, primary, Pennell, Nathan A., primary, Penny, Robert, primary, Perou, Charles M., primary, Pihl, Todd, primary, Ramirez, Nilsa C., primary, Rassl, Doris M., primary, Reid, Glen, primary, Reis, Rui M., primary, Reynolds, Sheila M., primary, Rice, David, primary, Richards, William G, primary, Roach, Jeffrey, primary, Rusch, Valerie, primary, Sadeghi, Sara, primary, Saksena, Gordon, primary, Sander, Chris, primary, Sato, Ayuko, primary, Scapulatempo-Neto, Cristovam, primary, Schein, Jacqueline E., primary, Schultz, Nikolaus, primary, Schumacher, Steven E., primary, Seiwert, Tanguy, primary, Severson, David T, primary, Shelton, Candace, primary, Shelton, Troy, primary, Sheridan, Robert, primary, Shi, Yan, primary, Shiraishi, Yuichi, primary, Shmulevich, Ilya, primary, Silveira, Henrique C. S., primary, Simons, Janae V., primary, Sipahimalani, Payal, primary, Skelly, Tara, primary, Sofia, Heidi J., primary, Soloway, Matthew G., primary, Spellman, Paul, primary, Stuart, Josh, primary, Sun, Qiang, primary, Tam, Angela, primary, Tan, Donghui, primary, Tarnuzzer, Roy, primary, Tatsuno, Kenji, primary, Taylor, Barry S, primary, Thiessen, Nina, primary, Thompson, Eric, primary, Tsao, Anne, primary, Tse, Kane, primary, Tsujimura, Tohru, primary, Valdivieso, Federico, primary, Van Den Berg, David J., primary, van Zandwijk, Nico, primary, Veluvolu, Umadevi, primary, Viana, Luciano S., primary, Voet, Douglas, primary, Wan, Yunhu, primary, Wang, Zhining, primary, Wang, Jing, primary, Weaver, Joellen, primary, Weinstein, John N., primary, Weisenberger, Daniel J., primary, Wilkerson, Matthew D., primary, Wise, Lisa, primary, Wistuba, Ignacio, primary, Wong, Tina, primary, Wu, Ye, primary, Yamamoto, Shogo, primary, Yang, Liming, primary, Zenklusen, Jean C., primary, Zhang, Jiashan, primary, Zhang, Hailei, primary, Zhang, Hongxin, primary, and Zmuda, Erik, primary

Published
2023
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22. Supplementary Data from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression

Author

Midorikawa, Yutaka, primary, Yamamoto, Shogo, primary, Tatsuno, Kenji, primary, Renard-Guillet, Claire, primary, Tsuji, Shingo, primary, Hayashi, Akimasa, primary, Ueda, Hiroki, primary, Fukuda, Shiro, primary, Fujita, Takanori, primary, Katoh, Hiroto, primary, Ishikawa, Shumpei, primary, Covington, Kyle R., primary, Creighton, Chad J., primary, Sugitani, Masahiko, primary, Wheeler, David A., primary, Shibata, Tatsuhiro, primary, Nagae, Genta, primary, Takayama, Tadatoshi, primary, and Aburatani, Hiroyuki, primary

Published
2023
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23. Supplementary Figure from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression

Author

Midorikawa, Yutaka, primary, Yamamoto, Shogo, primary, Tatsuno, Kenji, primary, Renard-Guillet, Claire, primary, Tsuji, Shingo, primary, Hayashi, Akimasa, primary, Ueda, Hiroki, primary, Fukuda, Shiro, primary, Fujita, Takanori, primary, Katoh, Hiroto, primary, Ishikawa, Shumpei, primary, Covington, Kyle R., primary, Creighton, Chad J., primary, Sugitani, Masahiko, primary, Wheeler, David A., primary, Shibata, Tatsuhiro, primary, Nagae, Genta, primary, Takayama, Tadatoshi, primary, and Aburatani, Hiroyuki, primary

Published
2023
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24. Supplementary Table from Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression

Author

Midorikawa, Yutaka, primary, Yamamoto, Shogo, primary, Tatsuno, Kenji, primary, Renard-Guillet, Claire, primary, Tsuji, Shingo, primary, Hayashi, Akimasa, primary, Ueda, Hiroki, primary, Fukuda, Shiro, primary, Fujita, Takanori, primary, Katoh, Hiroto, primary, Ishikawa, Shumpei, primary, Covington, Kyle R., primary, Creighton, Chad J., primary, Sugitani, Masahiko, primary, Wheeler, David A., primary, Shibata, Tatsuhiro, primary, Nagae, Genta, primary, Takayama, Tadatoshi, primary, and Aburatani, Hiroyuki, primary

Published
2023
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25. LMNA Mutations and Right Heart Failure in Cardiomyopathy Patients With Left Ventricular Assist Devices

Author

Yamada, Takanobu, primary, Nomura, Seitaro, additional, Amiya, Eisuke, additional, Katoh, Manami, additional, Inoue, Shunsuke, additional, Hatsuse, Satoshi, additional, Fujita, Kanna, additional, Ito, Masamichi, additional, Fujita, Takanori, additional, Bujo, Chie, additional, Tsuji, Masaki, additional, Ishida, Junichi, additional, Ko, Toshiyuki, additional, Yamada, Shintaro, additional, Katagiri, Mikako, additional, Sassa, Tatsuro, additional, Kinoshita, Osamu, additional, Nawata, Kan, additional, Tobita, Takashige, additional, Satoh, Masahiro, additional, Ishiwata, Jumpei, additional, Daimon, Masao, additional, Tatsuno, Kenji, additional, Fukuda, Shiro, additional, Kashimura, Takeshi, additional, Minamino, Tohru, additional, Hatano, Masaru, additional, Ono, Minoru, additional, Aburatani, Hiroyuki, additional, and Komuro, Issei, additional

Published
2023
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26. Distinct molecular profile of diffuse cerebellar gliomas

Author

Nomura, Masashi, Mukasa, Akitake, Nagae, Genta, Yamamoto, Shogo, Tatsuno, Kenji, Ueda, Hiroki, Fukuda, Shiro, Umeda, Takayoshi, Suzuki, Tomonari, Otani, Ryohei, Kobayashi, Keiichi, Maruyama, Takashi, Tanaka, Shota, Takayanagi, Shunsaku, Nejo, Takahide, Takahashi, Satoshi, Ichimura, Koichi, Nakamura, Taishi, Muragaki, Yoshihiro, Narita, Yoshitaka, Nagane, Motoo, Ueki, Keisuke, Nishikawa, Ryo, Shibahara, Junji, Aburatani, Hiroyuki, and Saito, Nobuhito

Published
2017
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28. The Effects of Topiroxostat, a Selective Xanthine Oxidoreductase Inhibitor, on Arterial Stiffness in Hyperuricemic Patients with Liver Dysfunction: A Sub-Analysis of the BEYOND-UA Study

Author

Fujishima, Yuya, primary, Nishizawa, Hitoshi, additional, Kawachi, Yusuke, additional, Nakamura, Takashi, additional, Akari, Seigo, additional, Ono, Yoshiyuki, additional, Fukuda, Shiro, additional, Kita, Shunbun, additional, Maeda, Norikazu, additional, Hoshide, Satoshi, additional, Shimomura, Iichiro, additional, and Kario, Kazuomi, additional

Published
2023
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29. Changes in Eating Behaviors and Their Associations with Weight Loss in Japanese Patients Who Underwent Laparoscopic Sleeve Gastrectomy

Author

Kimura, Yu, primary, Fujishima, Yuya, additional, Nishizawa, Hitoshi, additional, Saito, Takuro, additional, Miyazaki, Yasuhiro, additional, Shirahase, Keiko, additional, Tokuzawa, Chie, additional, Nagai, Naoko, additional, Fukuda, Shiro, additional, Maeda, Kazuhisa, additional, Maeda, Norikazu, additional, Doki, Yuichiro, additional, and Shimomura, Iichiro, additional

Published
2023
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31. Chronic hyperadiponectinemia induced by transgenic overexpression increases plasma exosomes without significantly improving glucose and lipid metabolism

Author

Kawada, Keitaro, primary, Kita, Shunbun, additional, Fukuda, Shiro, additional, Fukuoka, Keita, additional, Okita, Tomonori, additional, Kawada-Horitani, Emi, additional, Iioka, Masahito, additional, Sakaue, Taka-aki, additional, Kawachi, Yusuke, additional, Fujii, Kohei, additional, Kimura, Yu, additional, Otabe, Shuichi, additional, Fujishima, Yuya, additional, Nishizawa, Hitoshi, additional, Maeda, Norikazu, additional, and Shimomura, Iichiro, additional

Published
2023
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33. LMNA Mutations and Right Heart Failure in Patients With Cardiomyopathy and With Left Ventricular Assist Devices

Author

YAMADA, TAKANOBU, NOMURA, SEITARO, AMIYA, EISUKE, KATOH, MANAMI, INOUE, SHUNSUKE, HATSUSE, SATOSHI, FUJITA, KANNA, ITO, MASAMICHI, FUJITA, TAKANORI, BUJO, CHIE, TSUJI, MASAKI, ISHIDA, JUNICHI, KO, TOSHIYUKI, YAMADA, SHINTARO, KATAGIRI, MIKAKO, SASSA, TATSURO, KINOSHITA, OSAMU, NAWATA, KAN, TOBITA, TAKASHIGE, SATOH, MASAHIRO, ISHIWATA, JUMPEI, DAIMON, MASAO, TATSUNO, KENJI, FUKUDA, SHIRO, KASHIMURA, TAKESHI, MINAMINO, TOHRU, HATANO, MASARU, ONO, MINORU, ABURATANI, HIROYUKI, and KOMURO, ISSEI

Published
2023
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34. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

Author

FANTOM Consortium, Arner, Erik, Daub, Carsten O., Vitting-Seerup, Kristoffer, Andersson, Robin, Lilje, Berit, Drabløs, Finn, Lennartsson, Andreas, Rönnerblad, Michelle, Hrydziuszko, Olga, Vitezic, Morana, Freeman, Tom C., Alhendi, Ahmad M. N., Arner, Peter, Axton, Richard, Baillie, J. Kenneth, Beckhouse, Anthony, Bodega, Beatrice, Briggs, James, Brombacher, Frank, Davis, Margaret, Detmar, Michael, Ehrlund, Anna, Endoh, Mitsuhiro, Eslami, Afsaneh, Fagiolini, Michela, Fairbairn, Lynsey, Faulkner, Geoffrey J., Ferrai, Carmelo, Fisher, Malcolm E., Forrester, Lesley, Goldowitz, Daniel, Guler, Reto, Ha, Thomas, Hara, Mitsuko, Herlyn, Meenhard, Ikawa, Tomokatsu, Kai, Chieko, Kawamoto, Hiroshi, Khachigian, Levon M., Klinken, S. Peter, Kojima, Soichi, Koseki, Haruhiko, Klein, Sarah, Mejhert, Niklas, Miyaguchi, Ken, Mizuno, Yosuke, Morimoto, Mitsuru, Morris, Kelly J., Mummery, Christine, Nakachi, Yutaka, Ogishima, Soichi, Okada-Hatakeyama, Mariko, Okazaki, Yasushi, Orlando, Valerio, Ovchinnikov, Dmitry, Passier, Robert, Patrikakis, Margaret, Pombo, Ana, Qin, Xian-Yang, Roy, Sugata, Sato, Hiroki, Savvi, Suzana, Saxena, Alka, Schwegmann, Anita, Sugiyama, Daisuke, Swoboda, Rolf, Tanaka, Hiroshi, Tomoiu, Andru, Winteringham, Louise N., Wolvetang, Ernst, Yanagi-Mizuochi, Chiyo, Yoneda, Misako, Zabierowski, Susan, Zhang, Peter, Abugessaisa, Imad, Bertin, Nicolas, Diehl, Alexander D., Fukuda, Shiro, Furuno, Masaaki, Harshbarger, Jayson, Hasegawa, Akira, Hori, Fumi, Ishikawa-Kato, Sachi, Ishizu, Yuri, Itoh, Masayoshi, Kawashima, Tsugumi, Kojima, Miki, Kondo, Naoto, Lizio, Marina, Meehan, Terrence F., Mungall, Christopher J., Murata, Mitsuyoshi, Nishiyori-Sueki, Hiromi, Sahin, Serkan, Nagao-Sato, Sayaka, Severin, Jessica, de Hoon, Michiel J. L., Kawai, Jun, Kasukawa, Takeya, Lassmann, Timo, Suzuki, Harukazu, Kawaji, Hideya, Summers, Kim M., Wells, Christine, Hume, David A., Forrest, Alistair R. R., Sandelin, Albin, Carninci, Piero, and Hayashizaki, Yoshihide

Published
2015

35. DNA demethylation is associated with malignant progression of lower-grade gliomas

Author

Nomura, Masashi, Saito, Kuniaki, Aihara, Koki, Nagae, Genta, Yamamoto, Shogo, Tatsuno, Kenji, Ueda, Hiroki, Fukuda, Shiro, Umeda, Takayoshi, Tanaka, Shota, Takayanagi, Shunsaku, Otani, Ryohei, Nejo, Takahide, Hana, Taijun, Takahashi, Satoshi, Kitagawa, Yosuke, Omata, Mayu, Higuchi, Fumi, Nakamura, Taishi, Muragaki, Yoshihiro, Narita, Yoshitaka, Nagane, Motoo, Nishikawa, Ryo, Ueki, Keisuke, Saito, Nobuhito, Aburatani, Hiroyuki, and Mukasa, Akitake

Published
2019
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38. Cardiac neural crest lineage diversity and underlying gene regulatory networks revealed by multimodal analysis

Author

Iwase, Akiyasu, primary, Uchijima, Yasunobu, additional, Seya, Daiki, additional, Kida, Mayuko, additional, Higashiyama, Hiroki, additional, Matsui, Kazuhiro, additional, Izumi-Taguchi, Akashi, additional, Yamamoto, Shogo, additional, Fukuda, Shiro, additional, Nomura, Seitaro, additional, Kohro, Takahide, additional, Shukunami, Chisa, additional, Akiyama, Haruhiko, additional, Seki, Masahide, additional, Suzuki, Yutaka, additional, Wada, Youichiro, additional, Aburatani, Hiroyuki, additional, Kurihara, Yukiko, additional, Miyagawa-Tomita, Sachiko, additional, and Kurihara, Hiroki, additional

Published
2022
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39. Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia

Author

60451811, 00359621, Isobe, Tomoya, Takagi, Masatoshi, Sato-Otsubo, Aiko, Nishimura, Akira, Nagae, Genta, Yamagishi, Chika, Tamura, Moe, Tanaka, Yosuke, Asada, Shuhei, Takeda, Reina, Tsuchiya, Akiho, Wang, Xiaonan, Yoshida, Kenichi, Nannya, Yasuhito, Ueno, Hiroo, Akazawa, Ryo, Kato, Itaru, Mikami, Takashi, Watanabe, Kentaro, Sekiguchi, Masahiro, Seki, Masafumi, Kimura, Shunsuke, Hiwatari, Mitsuteru, Kato, Motohiro, Fukuda, Shiro, Tatsuno, Kenji, Tsutsumi, Shuichi, Kanai, Akinori, Inaba, Toshiya, Shiozawa, Yusuke, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Kotecha, Rishi S., Cruickshank, Mark N., Ishikawa, Fumihiko, Morio, Tomohiro, Eguchi, Mariko, Deguchi, Takao, Kiyokawa, Nobutaka, Arakawa, Yuki, Koh, Katsuyoshi, Aoki, Yuki, Ishihara, Takashi, Tomizawa, Daisuke, Miyamura, Takako, Ishii, Eiichi, Mizutani, Shuki, Wilson, Nicola K., Göttgens, Berthold, Miyano, Satoru, Kitamura, Toshio, Goyama, Susumu, Yokoyama, Akihiko, Aburatani, Hiroyuki, Ogawa, Seishi, Takita, Junko, 60451811, 00359621, Isobe, Tomoya, Takagi, Masatoshi, Sato-Otsubo, Aiko, Nishimura, Akira, Nagae, Genta, Yamagishi, Chika, Tamura, Moe, Tanaka, Yosuke, Asada, Shuhei, Takeda, Reina, Tsuchiya, Akiho, Wang, Xiaonan, Yoshida, Kenichi, Nannya, Yasuhito, Ueno, Hiroo, Akazawa, Ryo, Kato, Itaru, Mikami, Takashi, Watanabe, Kentaro, Sekiguchi, Masahiro, Seki, Masafumi, Kimura, Shunsuke, Hiwatari, Mitsuteru, Kato, Motohiro, Fukuda, Shiro, Tatsuno, Kenji, Tsutsumi, Shuichi, Kanai, Akinori, Inaba, Toshiya, Shiozawa, Yusuke, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Kotecha, Rishi S., Cruickshank, Mark N., Ishikawa, Fumihiko, Morio, Tomohiro, Eguchi, Mariko, Deguchi, Takao, Kiyokawa, Nobutaka, Arakawa, Yuki, Koh, Katsuyoshi, Aoki, Yuki, Ishihara, Takashi, Tomizawa, Daisuke, Miyamura, Takako, Ishii, Eiichi, Mizutani, Shuki, Wilson, Nicola K., Göttgens, Berthold, Miyano, Satoru, Kitamura, Toshio, Goyama, Susumu, Yokoyama, Akihiko, Aburatani, Hiroyuki, Ogawa, Seishi, and Takita, Junko

Abstract

KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) represents the most refractory type of childhood leukemia. To uncover the molecular heterogeneity of this disease, we perform RNA sequencing, methylation array analysis, whole exome and targeted deep sequencing on 84 infants with KMT2A-rearranged leukemia. Our multi-omics clustering followed by single-sample and single-cell inference of hematopoietic differentiation establishes five robust integrative clusters (ICs) with different master transcription factors, fusion partners and corresponding stages of B-lymphopoietic and early hemato-endothelial development: IRX-type differentiated (IC1), IRX-type undifferentiated (IC2), HOXA-type MLLT1 (IC3), HOXA-type MLLT3 (IC4), and HOXA-type AFF1 (IC5). Importantly, our deep mutational analysis reveals that the number of RAS pathway mutations predicts prognosis and that the most refractory subgroup of IC2 possesses 100% frequency and the heaviest burden of RAS pathway mutations. Our findings highlight the previously under-appreciated intra- and inter-patient heterogeneity of KMT2A-rearranged infant ALL and provide a rationale for the future development of genomics-guided risk stratification and individualized therapy.

Published
2022

40. Adiponectin Accumulation in the Tetinal Vascular Endothelium and its Possible Role in Preventing Early Diabetic Microvascular Damage

Author

Sakaue, Taka-aki, primary, Fujishima, Yuya, additional, Fukushima, Yoko, additional, Tsugawa-Shimizu, Yuri, additional, Fukuda, Shiro, additional, Kita, Shunbun, additional, Nishizawa, Hitoshi, additional, Ranscht, Barbara, additional, Nishida, Kohji, additional, Maeda, Norikazu, additional, and Shimomura, Iichiro, additional

Published
2021
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41. Increased plasma XOR activity induced by NAFLD/NASH and its possible involvement in vascular neointimal proliferation

Author

Kawachi, Yusuke, primary, Fujishima, Yuya, additional, Nishizawa, Hitoshi, additional, Nakamura, Takashi, additional, Akari, Seigo, additional, Murase, Takayo, additional, Saito, Takuro, additional, Miyazaki, Yasuhiro, additional, Nagao, Hirofumi, additional, Fukuda, Shiro, additional, Kita, Shunbun, additional, Katakami, Naoto, additional, Doki, Yuichiro, additional, Maeda, Norikazu, additional, and Shimomura, Iichiro, additional

Published
2021
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42. GENE REGULATION: Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

Author

Arner, Erik, Daub, Carsten O., Vitting-Seerup, Kristoffer, Andersson, Robin, Lilje, Berit, Drabløs, Finn, Lennartsson, Andreas, Rönnerblad, Michelle, Hrydziuszko, Olga, Vitezic, Morana, Freeman, Tom C., Alhendi, Ahmad M. N., Arner, Peter, Axton, Richard, Baillie, Kenneth J., Beckhouse, Anthony, Bodega, Beatrice, Briggs, James, Brombacher, Frank, Davis, Margaret, Detmar, Michael, Ehrlund, Anna, Endoh, Mitsuhiro, Eslami, Afsaneh, Fagiolini, Michela, Fairbairn, Lynsey, Faulkner, Geoffrey J., Ferrai, Carmelo, Fisher, Malcolm E., Forrester, Lesley, Goldowitz, Daniel, Guler, Reto, Ha, Thomas, Hara, Mitsuko, Herlyn, Meenhard, Ikawa, Tomokatsu, Kai, Chieko, Kawamoto, Hiroshi, Khachigian, Levon M., Klinken, Peter S., Kojima, Soichi, Koseki, Haruhiko, Klein, Sarah, Mejhert, Niklas, Miyaguchi, Ken, Mizuno, Yosuke, Morimoto, Mitsuru, Morris, Kelly J., Mummery, Christine, Nakachi, Yutaka, Ogishima, Soichi, Okada-Hatakeyama, Mariko, Okazaki, Yasushi, Orlando, Valerio, Ovchinnikov, Dmitry, Passier, Robert, Patrikakis, Margaret, Pombo, Ana, Qin, Xian-Yang, Roy, Sugata, Sato, Hiroki, Savvi, Suzana, Saxena, Alka, Schwegmann, Anita, Sugiyama, Daisuke, Swoboda, Rolf, Tanaka, Hiroshi, Tomoiu, Andru, Winteringham, Louise N., Wolvetang, Ernst, Yanagi-Mizuochi, Chiyo, Yoneda, Misako, Zabierowski, Susan, Zhang, Peter, Abugessaisa, Imad, Bertin, Nicolas, Diehl, Alexander D., Fukuda, Shiro, Furuno, Masaaki, Harshbarger, Jayson, Hasegawa, Akira, Hori, Fumi, Ishikawa-Kato, Sachi, Ishizu, Yuri, Itoh, Masayoshi, Kawashima, Tsugumi, Kojima, Miki, Kondo, Naoto, Lizio, Marina, Meehan, Terrence F., Mungall, Christopher J., Murata, Mitsuyoshi, Nishiyori-Sueki, Hiromi, Sahin, Serkan, Nagao-Sato, Sayaka, Severin, Jessica, de Hoon, Michiel J. L., Kawai, Jun, Kasukawa, Takeya, Lassmann, Timo, Suzuki, Harukazu, Kawaji, Hideya, Summers, Kim M., Wells, Christine, Hume, David A., Forrest, Alistair R. R., Sandelin, Albin, Carninci, Piero, and Hayashizaki, Yoshihide

Published
2015
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45. Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment

Author

Kawachi, Yusuke, primary, Fujishima, Yuya, additional, Nishizawa, Hitoshi, additional, Nagao, Hirofumi, additional, Nakamura, Takashi, additional, Akari, Seigo, additional, Murase, Takayo, additional, Taya, Naohiro, additional, Omori, Kazuo, additional, Miyake, Akimitsu, additional, Fukuda, Shiro, additional, Takahara, Mitsuyoshi, additional, Kita, Shunbun, additional, Katakami, Naoto, additional, Maeda, Norikazu, additional, and Shimomura, Iichiro, additional

Published
2020
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46. Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression

Author

Midorikawa, Yutaka, primary, Yamamoto, Shogo, additional, Tatsuno, Kenji, additional, Renard-Guillet, Claire, additional, Tsuji, Shingo, additional, Hayashi, Akimasa, additional, Ueda, Hiroki, additional, Fukuda, Shiro, additional, Fujita, Takanori, additional, Katoh, Hiroto, additional, Ishikawa, Shumpei, additional, Covington, Kyle R., additional, Creighton, Chad J., additional, Sugitani, Masahiko, additional, Wheeler, David A., additional, Shibata, Tatsuhiro, additional, Nagae, Genta, additional, Takayama, Tadatoshi, additional, and Aburatani, Hiroyuki, additional

Published
2020
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47. Defined lifestyle and germline factors predispose Asian populations to gastric cancer

Author

Suzuki, Akihiro, primary, Katoh, Hiroto, additional, Komura, Daisuke, additional, Kakiuchi, Miwako, additional, Tagashira, Amane, additional, Yamamoto, Shogo, additional, Tatsuno, Kenji, additional, Ueda, Hiroki, additional, Nagae, Genta, additional, Fukuda, Shiro, additional, Umeda, Takayoshi, additional, Totoki, Yasushi, additional, Abe, Hiroyuki, additional, Ushiku, Tetsuo, additional, Matsuura, Tetsuya, additional, Sakai, Eiji, additional, Ohshima, Takashi, additional, Nomura, Sachiyo, additional, Seto, Yasuyuki, additional, Shibata, Tatsuhiro, additional, Rino, Yasushi, additional, Nakajima, Atsushi, additional, Fukayama, Masashi, additional, Ishikawa, Shumpei, additional, and Aburatani, Hiroyuki, additional

Published
2020
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49. Efficacy of Late Steroid Pulse Therapy for ARDS Following Influenza Pneumonia: A Case Report

Author

Fukuda, Shiro, Miyake, Nanae, and Matayoshi, Hiroaki

Subjects
ステロイド, インフルエンザ, steroid, 肺炎, pneumonia, ARDS, influenza
Abstract

The patient was a 15-year-old girl who received laryngotracheal separation. Influenza A was detected upon examination due to fever (41°C) and dyspnea; the patient was admitted, and it was suspected that the onset of ARDS occurred subsequently. The patient was admitted to the ICU of our hospital for respiratory management. However, because an amelioration of respiratory organ symptoms was not noted, steroid pulse therapy was performed for three days from hospital day 14. P/F ratio was subsequently maintained at 200 or higher from hospital day 23. The patient was discharged from the ICU on hospital day 76.

Published
2017

50. Plasma xanthine oxidoreductase activity in Japanese patients with type2 diabetes across hospitalized treatment

Author

Kawachi, Yusuke, 1000010779789, Fujishima, Yuya, 1000020379259, Nishizawa, Hitoshi, Nagao, Hirofumi, Nakamura, Takashi, Akari, Seigo, Murase, Takayo, Taya, Naohiro, Omori, Kazuo, Miyake, Akimitsu, 1000000896467, Fukuda, Shiro, 1000000751067, Takahara, Mitsuyoshi, 1000010746572, 0000-0002-8937-0053, Kita, Shunbun, 1000010403049, Katakami, Naoto, 1000030506308, Maeda, Norikazu, 1000060346145, 0000-0003-4244-1384, Shimomura, Iichiro, Kawachi, Yusuke, 1000010779789, Fujishima, Yuya, 1000020379259, Nishizawa, Hitoshi, Nagao, Hirofumi, Nakamura, Takashi, Akari, Seigo, Murase, Takayo, Taya, Naohiro, Omori, Kazuo, Miyake, Akimitsu, 1000000896467, Fukuda, Shiro, 1000000751067, Takahara, Mitsuyoshi, 1000010746572, 0000-0002-8937-0053, Kita, Shunbun, 1000010403049, Katakami, Naoto, 1000030506308, Maeda, Norikazu, 1000060346145, 0000-0003-4244-1384, and Shimomura, Iichiro

Abstract

Yusuke Kawachi; Yuya Fujishima; Hitoshi Nishizawa; Hirofumi Nagao; Takashi Nakamura; Seigo Akari; Takayo Murase; Naohiro Taya; Kazuo Omori; Akimitsu Miyake; Shiro Fukuda; Mitsuyoshi Takahara; Shunbun Kita; Naoto Katakami; Norikazu Maeda; Iichiro Shimomura. Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment. J Diabetes Investig. 2020., Aims/Introduction: Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine and xanthine to xanthine and uric acid, respectively. Plasma XOR activity has recently been measured in humans. However, limited information is known about plasma XOR activity in patients with type2 diabetes mellitus, and its changes after short-term glycemic control treatment. Materials and Methods: We enrolled 28 Japanese patients (10 men/18 women) with type2 diabetes mellitus who were hospitalized to undergo medical treatment for diabetes. Plasma XOR activity, quantified using triple quadrupole mass spectrometry and liquid chromatography, and other clinical parameters were examined at admission and 2weeks after treatment during hospitalization. Changes in plasma XOR activity after treatment during hospitalization and associated clinical parameters were assessed. Results: At the time of admission, the median plasma XOR activity was 83.1pmol/h/mL, with a wide range of 14.4–1150pmol/h/mL. Multiple regression analysis identified serum aspartate transaminase and alanine transaminase levels as significant and independent factors correlating with the baseline plasma XOR. Two weeks of treatment during hospitalization was associated with a significant decrease in plasma XOR activity. Changes in serum aspartate transaminase were also the only significant and independent factor correlating with changes in plasma XOR activity. Conclusions: A close relationship was observed between plasma XOR activity and liver transaminases in patients with type2 diabetes mellitus, cross-sectionally, and also across treatment during hospitalization.

Published
2020

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