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1. Correction to: Prevalence and predictors of bowel dysfunction in a large multiple sclerosis outpatient population: an Italian multicenter study

Author

Bisecco, Alvino, Fornasiero, Arianna, Bianco, Assunta, Cortese, Antonio, D’Amico, Emanuele, Mataluni, Giorgia, Sinisi, Leonardo, Spitaleri, Daniele, Docimo, Renato, Buscarinu, Maria Chiara, Mirabella, Massimiliano, Crisafulli, Sebastiano Giuseppe, Zanghì, Aurora, Nicoletti, Carolina Gabri, Salvetti, Marco, Baione, Viola, Patti, Francesco, Marfia, Alessandra Girolama, Sibilia, Grazia, Scarano, Valentina, Orlando, Davide, Stabile, Giovanni, Tedeschi, Gioacchino, and Gallo, Antonio

Published
2022
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2. Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients

Author

Annibali, Viviana, Umeton, Renato, Palermo, Antonia, Severa, Martina, Etna, Marilena Paola, Giglio, Simona, Romano, Silvia, Ferraldeschi, Michela, Buscarinu, Maria Chiara, Vecchione, Andrea, Annese, Anita, Policano, Claudia, Mechelli, Rosella, Pizzolato Umeton, Raffaella, Fornasiero, Arianna, Angelini, Daniela Francesca, Guerrera, Gisella, Battistini, Luca, Coccia, Eliana Marina, Salvetti, Marco, and Ristori, Giovanni

Published
2018
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3. Bacille Calmette-Guérin (BCG) Vaccine in Neuroinflammation

Author

Romano, Silvia, primary, Ferraldeschi, Michela, additional, Buscarinu, Maria Chiara, additional, Fornasiero, Arianna, additional, Reniè, Roberta, additional, Morena, Emanuele, additional, Romano, Carmela, additional, Mechelli, Rosella, additional, Vanacore, Nicola, additional, Salvetti, Marco, additional, and Ristori, Giovanni, additional

Published
2018
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4. Contributors

Author

Aaby, P., primary, Arts, Rob J.W., additional, Benn, C.S., additional, Birk, Nina Marie, additional, Bloom, Barry R., additional, Bruiners, Natalie, additional, Buscarinu, Maria Chiara, additional, Curtis, Nigel, additional, Das, Gobardhan, additional, Dockrell, Hazel M., additional, Faustman, Denise L., additional, Ferraldeschi, Michela, additional, Fornasiero, Arianna, additional, Gennaro, Maria Laura, additional, Guerrini, Valentina, additional, Jensen, K.J., additional, Kjærgaard, Jesper, additional, Mechelli, Rosella, additional, Messina, Nicole L., additional, Morena, Emanuele, additional, Netea, Mihai G., additional, Nissen, Thomas Nørrelykke, additional, Novakovic, Boris, additional, Reniè, Roberta, additional, Rieckmann, A., additional, Ristori, Giovanni, additional, Romano, Silvia, additional, Romano, Carmela, additional, Rook, Graham A.W., additional, Salvetti, Marco, additional, Singh, Mona, additional, Vanacore, Nicola, additional, and Yadav, Vinod, additional

Published
2018
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5. Fingolimod vs dimethyl fumarate in multiple sclerosis: A real-world propensity score-matched study

Author

Prosperini, Luca, Lucchini, Matteo, Haggiag, Shalom, Bellantonio, Paolo, Bianco, Assunta, Buscarinu, Maria Chiara, Buttari, Fabio, Centonze, Diego, Cortese, Antonio, De Giglio, Laura, Fantozzi, Roberta, Ferraro, Elisabetta, Fornasiero, Arianna, Francia, Ada, Galgani, Simonetta, Gasperini, Claudio, Marfia, Girolama Alessandra, Millefiorini, Enrico, Nociti, Viviana, Pontecorvo, Simona, Pozzilli, Carlo, Ruggieri, Serena, Salvetti, Marco, Sgarlata, Eleonora, and Mirabella, Massimiliano

Published
2018
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6. Contributors

Author

Alimonti, Alessandro, primary, Aschner, Michael, additional, Bichell, Terry Jo V., additional, Bondy, Stephen C., additional, Borghesani, Valentina, additional, Bowman, Aaron B., additional, Brescianini, Sonia, additional, Brown, David R., additional, Buscarinu, Maria C., additional, Bush, Ashley I., additional, Cardoso, Bárbara R., additional, Cerasoli, Benedetta, additional, Chen, Jingyuan, additional, Connor, James R., additional, Costa, Lucio G., additional, Crouch, Peter J., additional, del Barrio, Melisa, additional, Dorman, David C., additional, Faller, Peter, additional, Ferraldeschi, Michela, additional, Fornasiero, Arianna, additional, Grabrucker, Andreas M., additional, Grabrucker, Stefanie, additional, Greenough, Mark A., additional, Halbesma, Timothy C., additional, Hare, Dominic J., additional, Hureau, Christelle, additional, Jiang, Hong, additional, Kanninen, Katja M., additional, Konttinen, Henna, additional, Lejavová, Katarína, additional, Lewis, Frank W., additional, Luo, Wenjing, additional, Malm, Tarja, additional, Marques dos Santos, Dinamene, additional, Marreilha dos Santos, Ana P., additional, Mattei, Carlo, additional, Mechelli, Rosella, additional, Mot, Alexandra I., additional, Nixon, Anne M., additional, Opazo, Carlos M., additional, Perry, George, additional, Pino, Anna, additional, Plascencia-Villa, Germán, additional, Ramírez Muñoz, Alejandra, additional, Ristori, Giovanni, additional, Romano, Silvia, additional, Roos, Per M., additional, Salustri, Carlo, additional, Salvetti, Marco, additional, Siotto, Mariacristina, additional, Squitti, Rosanna, additional, Stazi, Maria A., additional, Su, Peng, additional, Tétard, David, additional, Tipps, K. Grace, additional, Ventriglia, Mariacarla, additional, White, Anthony R., additional, and José-Yacamán, Miguel, additional

Published
2017
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7. Chemical Elements and Oxidative Status in Neuroinflammation

Author

Ferraldeschi, Michela, primary, Romano, Silvia, additional, Buscarinu, Maria C., additional, Fornasiero, Arianna, additional, Mechelli, Rosella, additional, Cerasoli, Benedetta, additional, Pino, Anna, additional, Brescianini, Sonia, additional, Mattei, Carlo, additional, Stazi, Maria A., additional, Alimonti, Alessandro, additional, Salvetti, Marco, additional, and Ristori, Giovanni, additional

Published
2017
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8. Intestinal Permeability and Circulating CD161+CCR6+CD8+T Cells in Patients With Relapsing–Remitting Multiple Sclerosis Treated With Dimethylfumarate

Author

Buscarinu, Maria C., primary, Gargano, Francesca, additional, Lionetto, Luana, additional, Capi, Matilde, additional, Morena, Emanuele, additional, Fornasiero, Arianna, additional, Reniè, Roberta, additional, Landi, Anna C., additional, Pellicciari, Giulia, additional, Romano, Carmela, additional, Mechelli, Rosella, additional, Romano, Silvia, additional, Borsellino, Giovanna, additional, Battistini, Luca, additional, Simmaco, Maurizio, additional, Fagnani, Corrado, additional, Salvetti, Marco, additional, and Ristori, Giovanni, additional

Published
2021
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9. Prevalence and predictors of bowel dysfunction in a large multiple sclerosis outpatient population: an Italian multicenter study

Author

Sinisi Leonardo, Cortese Antonio, Mataluni Giorgia, Baione Viola, Sibilia Grazia, Antonio Gallo, Mirabella Massimiliano, Stabile Giovanni, Bisecco Alvino, d'Amico Emanuele, Carolina Gabri Nicoletti, Scarano Valentina, Docimo Renato, Fornasiero Arianna, Patti Francesco, Sebastiano Giuseppe Crisafulli, Orlando Davide, Tedeschi Gioacchino, Bianco Assunta, Zanghì Aurora, Spitaleri Daniele, Alessandra Girolama Marfia, Salvetti Marco, Maria Chiara Buscarinu, Bisecco, Alvino, Arianna, F., Assunta, B., Antonio, C., Emanuele, A., Giorgia, M., Leonardo, S., Daniele, S., Renato, D., Buscarinu, M. C., Massimiliano, M., Crisafulli, S. G., Aurora, Z., Gabri Nicoletti, C., Marco, S., Viola, B., Francesco, P., Marfia, A. G., Grazia, S., Valentina, S., Davide, O., Giovanni, S., Gioacchino, T., and Gallo, A.

Subjects
medicine.medical_specialty, Neurology, Multiple Sclerosis, bowel, gut dysfunction, multicenter study, multiple sclerosis, symptoms, Gastrointestinal Diseases, Gastrointestinal Disease, Symptom, Population, Logistic regression, Neurogenic Bowel, Internal medicine, Outpatients, medicine, Prevalence, Humans, Multiple sclerosi, Disabled Persons, education, Neuroradiology, education.field_of_study, Expanded Disability Status Scale, business.industry, Multiple sclerosis, Outpatient, medicine.disease, Bowel dysfunction, Settore MED/26 - NEUROLOGIA, Disabled Person, Female, Neurology (clinical), business, Human
Abstract

Introduction Bowel dysfunction (BD) is reported as a common and disabling symptom in multiple sclerosis (MS) patients. To date, no studies have explored the prevalence of these symptoms in a large multicenter outpatient setting. The aims of the present study are to assess: (i) the prevalence of BD in a large multicenter Italian MS population, and (ii) the correlation between clinico-demographic variables and the severity of BD. Methods Each of the nine participating center screened MS patients prospectively: 1100 subjects were enrolled. All patients underwent the Expanded Disability Status Scale (EDSS) and completed the Neurogenic Bowel Dysfunction score (NBDs). Multivariable linear and logistic regression models were used to assess the association between NBDs and several clinico-demographic variables. Results Fourteen percent of MS patients showed a moderate/severe BD (NBDs > 10); this percentage increased in patients with high disability, ranging from 26 to 32%. Moderate/severe BD was more frequent in MS patients with: progressive phenotypes, higher disability, older age, and longer disease duration. NBDs severity was predicted by female sex, ambulation impairment and bladder symptoms. Conclusion This study confirms the relatively high prevalence of moderate/severe BD in a large, multicenter, unselected, outpatient MS population. BD appears to be mainly associated to female sex and MS-related disability.

Published
2021

12. The Contribution of Gut Barrier Changes to Multiple Sclerosis Pathophysiology

Author

Buscarinu, Maria Chiara, primary, Fornasiero, Arianna, additional, Romano, Silvia, additional, Ferraldeschi, Michela, additional, Mechelli, Rosella, additional, Reniè, Roberta, additional, Morena, Emanuele, additional, Romano, Carmela, additional, Pellicciari, Giulia, additional, Landi, Anna Chiara, additional, Salvetti, Marco, additional, and Ristori, Giovanni, additional

Published
2019
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13. Drug Holiday of Interferon Beta 1b in Multiple Sclerosis: A Pilot, Randomized, Single Blind Study of Non-inferiority

Author

Romano, Silvia, primary, Ferraldeschi, Michela, additional, Bagnato, Francesca, additional, Mechelli, Rosella, additional, Morena, Emanuele, additional, Caldano, Marzia, additional, Buscarinu, Maria Chiara, additional, Fornasiero, Arianna, additional, Frontoni, Marco, additional, Nociti, Viviana, additional, Mirabella, Massimiliano, additional, Mayer, Flavia, additional, Bertolotto, Antonio, additional, Pozzilli, Carlo, additional, Vanacore, Nicola, additional, Salvetti, Marco, additional, and Ristori, Giovanni, additional

Published
2019
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14. Genome-Wide Multiple Sclerosis Association Data and Coagulation

Author

La Starza, Sara, primary, Ferraldeschi, Michela, additional, Buscarinu, Maria Chiara, additional, Romano, Silvia, additional, Fornasiero, Arianna, additional, Mechelli, Rosella, additional, Umeton, Renato, additional, Ristori, Giovanni, additional, and Salvetti, Marco, additional

Published
2019
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16. Fingolimod vs dimethyl fumarate in multiple sclerosis

Author

Prosperini, Luca, Lucchini, Matteo, Haggiag, Shalom, Bellantonio, Paolo, Bianco, Assunta, Buscarinu, Maria Chiara, Buttari, Fabio, Centonze, Diego, Cortese, Antonio, De Giglio, Laura, Fantozzi, Roberta, Ferraro, Elisabetta, Fornasiero, Arianna, Francia, Ada, Galgani, Simonetta, Gasperini, Claudio, Marfia, Girolama Alessandra, Millefiorini, Enrico, Nociti, Viviana, Pontecorvo, Simona, Pozzilli, Carlo, Ruggieri, Serena, Salvetti, Marco, Sgarlata, Eleonora, and Mirabella, Massimiliano

Subjects
Multiple sclerosis, case control), Settore MED/26 - NEUROLOGIA, Multiple sclerosis, class IV, clinical trials observational studies (Cohort, case control), class IV, clinical trials observational studies (Cohort
Published
2018

17. Corrigendum to “Novel homozygous GBA2 mutation in a patient with complicated spastic paraplegia” [Clin. Neurol. Neurosurg. 168 (May) (2018) 60–63]

Author

Coarelli, Giulia, primary, Romano, Silvia, additional, Travaglini, Lorena, additional, Ferraldeschi, Michela, additional, Nicita, Francesco, additional, Spadaro, Maria, additional, Fornasiero, Arianna, additional, Frontali, Marina, additional, Salvetti, Marco, additional, Bertini, Enrico, additional, and Ristori, Giovanni, additional

Published
2018
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20. Rhizome

Author

Fornasiero, Arianna (author), Turconi, Paolo (author), Fornasiero, Arianna (author), and Turconi, Paolo (author)

Abstract

The sequence of socio-spatial layers that connects the public space to the inner communal space and finally to the private space of the house, was the crucial quality of the area that came about during the last phase of analysis and what the project aims to preserve. Through an objective examination of the spaces encountered, it was possible to find the patterns that govern social life in the Menen and enrich this site. Indeed, the design research phase brought us to the formulation of a clear research question. How can the different socio-spatial layers, that characterize the fabric of the Menen, be reinterpreted into a low-rise project able to reach the same density of the Condominium blocks? How can the project be feasible and promote itself as flexible standardized system? Hence, we challenged ourselves in designing a “system” able to reinterpret the hierarchy of spaces of the site, as well as a project that has embedded the flexibility to be standardized., Architecture, Urbanism and Building Sciences | Dwelling

Published
2017

21. Altered intestinal permeability in patients with relapsing–remitting multiple sclerosis: A pilot study

Author

Buscarinu, Maria Chiara, primary, Cerasoli, Benedetta, additional, Annibali, Viviana, additional, Policano, Claudia, additional, Lionetto, Luana, additional, Capi, Matilde, additional, Mechelli, Rosella, additional, Romano, Silvia, additional, Fornasiero, Arianna, additional, Mattei, Gianluca, additional, Piras, Eleonora, additional, Angelini, Daniela Francesca, additional, Battistini, Luca, additional, Simmaco, Maurizio, additional, Umeton, Renato, additional, Salvetti, Marco, additional, and Ristori, Giovanni, additional

Published
2016
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22. IFN-β Therapy Regulates TLR7-Mediated Response in Plasmacytoid Dendritic Cells of Multiple Sclerosis Patients Influencing an Anti-Inflammatory Status

Author

Severa, Martina, primary, Rizzo, Fabiana, additional, Giacomini, Elena, additional, Annibali, Viviana, additional, Gafa, Valerie, additional, Romano, Silvia, additional, Buscarinu, Maria Chiara, additional, Fornasiero, Arianna, additional, Salvetti, Marco, additional, and Coccia, Eliana Marina, additional

Published
2015
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23. Altered intestinal permeability in patients with relapsing–remitting multiple sclerosis: A pilot study.

Author

Buscarinu, Maria Chiara, Cerasoli, Benedetta, Annibali, Viviana, Policano, Claudia, Mechelli, Rosella, Romano, Silvia, Fornasiero, Arianna, Mattei, Gianluca, Umeton, Renato, Salvetti, Marco, Ristori, Giovanni, Lionetto, Luana, Capi, Matilde, Simmaco, Maurizio, Piras, Eleonora, Angelini, Daniela Francesca, and Battistini, Luca

Subjects
MULTIPLE sclerosis diagnosis, INTESTINAL diseases, DISEASE relapse, PATHOGENIC microorganisms, MULTIPLE sclerosis treatment, T cells
Abstract

Background: Alterations of intestinal permeability (IP) may contribute to the pathophysiology of immune-mediated diseases. Objective: We investigated the possible association between IP changes and multiple sclerosis (MS). Methods: We studied 22 patients with relapsing–remitting multiple sclerosis (RRMS) and 18 age- and sex-matched healthy donors (HDs), including five twin pairs (one concordant, and four discordant for disease). Measurement of lactulose (L) and mannitol (M; two non-metabolized sugars) levels in urine samples, after an oral load, allowed to quantify gut dysfunction. Results: The proportion of participants with increased IP was significantly higher in patients than in HDs (16/22 (73%) versus 5/18 (28%); p = 0.001). Accordingly, the L/M urinary ratio showed significantly higher values in patients than in controls (p = 0.0284). Urinary mannitol concentration was significantly lower in patients than in controls (p = 0.022), suggesting a deficit of absorption from intestinal lumen. Such changes did not appear related to patients’ clinical–radiological features. Conclusion: The relatively high proportion of IP changes in RR-MS patients seems to confirm our work hypothesis and warrants more work to confirm the result on a larger sample, and to understand the implications for related immunological disturbances and intestinal microbiota alterations. Our finding may also have relevance for oral treatments, recently introduced in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2017
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24. Epstein-Barr virus genetic variants are associated with multiple sclerosis.

Author

Mechelli, Rosella, Manzari, Caterina, Policano, Claudia, Annese, Anita, Picardi, Ernesto, Umeton, Renato, Fornasiero, Arianna, D'Erchia, Anna Maria, Buscarinu, Maria Chiara, Agliardi, Cristina, Annibali, Viviana, Serafini, Barbara, Rosicarelli, Barbara, Romano, Silvia, Angelini, Daniela F, Ricigliano, Vito A G, Buttari, Fabio, Battistini, Luca, Centonze, Diego, and Guerini, Franca R

Published
2015
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25. Italian Alemtuzumab Study Group. No evidence of disease activity (NEDA-3) and disability improvement after alemtuzumab treatment for multiple sclerosis: a 36-month real-world study

Author

Luca Prosperini, Pietro Annovazzi, Laura Boffa, Maria Chiara Buscarinu, Antonio Gallo, Manuela Matta, Lucia Moiola, Luigina Musu, Paola Perini, Carlo Avolio, Valeria Barcella, Assunta Bianco, Deborah Farina, Elisabetta Ferraro, Simona Pontecorvo, Franco Granella, Luigi M E Grimaldi, Alice Laroni, Giacomo Lus, Francesco Patti, Eugenio Pucci, Matteo Pasca, Paola Sarchielli, Angelo Ghezzi, Mauro Zaffaroni, Damiano Baroncini, Fabio Buttari, Diego Centonze, Arianna Fornasiero, Marco Salvetti, Renato Docimo, Elisabetta Signoriello, Gioacchino Tedeschi, Antonio Bertolotto, Marco Capobianco, Giancarlo Comi, Eleonora Cocco, Paolo Gallo, Marco Puthenparampil, Roberta Grasso, Valeria Di Francescantonio, Maria Rosaria Rottoli, Massimiliano Mirabella, Alessandra Lugaresi, Giovanna De Luca, Maria Di Ioia, Valeria Di Tommaso, Luca Mancinelli, Giancarlo Di Battista, Ada Francia, Serena Ruggieri, Carlo Pozzilli, Erica Curti, Elena Tsantes, Barbara Palmeri, Caterina Lapicci, Giovanni Luigi Mancardi, Antonio Uccelli, Clara Chisari, Emanuele D'Amico, Elisabetta Cartechini, Anna Maria Repice, Eliana Magnani, Luca Massaccesi, Paolo Calabresi, Massimiliano Di Filippo, Maria Di Gregorio, Prosperini, Luca, Annovazzi, Pietro, Boffa, Laura, Chiara Buscarinu, Maria, Gallo, Antonio, Matta, Manuela, Moiola, Lucia, Musu, Luigina, Perini, Paola, Avolio, Carlo, Barcella, Valeria, Bianco, Assunta, Farina, Deborah, Ferraro, Elisabetta, Pontecorvo, Simona, Granella, Franco, E Grimaldi, Luigi M, Laroni, Alice, Lus, Giacomo, Patti, Francesco, Pucci, Eugenio, Pasca, Matteo, Sarchielli, Paola, Ghezzi, Angelo, Zaffaroni, Mauro, Baroncini, Damiano, Buttari, Fabio, Centonze, Diego, Fornasiero, Arianna, Salvetti, Marco, Docimo, Renato, Signoriello, Elisabetta, Tedeschi, Gioacchino, Bertolotto, Antonio, Capobianco, Marco, Comi, Giancarlo, Cocco, Eleonora, Gallo, Paolo, Puthenparampil, Marco, Grasso, Roberta, Di Francescantonio, Valeria, Rosaria Rottoli, Maria, Mirabella, Massimiliano, Lugaresi, Alessandra, De Luca, Giovanna, Di Ioia, Maria, Di Tommaso, Valeria, Mancinelli, Luca, Di Battista, Giancarlo, Francia, Ada, Ruggieri, Serena, Pozzilli, Carlo, Curti, Erica, Tsantes, Elena, Palmeri, Barbara, Lapicci, Caterina, Luigi Mancardi, Giovanni, Uccelli, Antonio, Chisari, Clara, D'Amico, Emanuele, Cartechini, Elisabetta, Maria Repice, Anna, Magnani, Eliana, Massaccesi, Luca, Calabresi, Paolo, Di Filippo, Massimiliano, and Di Gregorio, Maria

Published
2018

26. Altered intestinal permeability in patients with relapsing-remitting multiple sclerosis: A pilot study.

Author

Buscarinu MC, Cerasoli B, Annibali V, Policano C, Lionetto L, Capi M, Mechelli R, Romano S, Fornasiero A, Mattei G, Piras E, Angelini DF, Battistini L, Simmaco M, Umeton R, Salvetti M, and Ristori G

Subjects
Adult, Female, Gastrointestinal Agents therapeutic use, Gastrointestinal Microbiome drug effects, Humans, Middle Aged, Permeability drug effects, Pilot Projects, Gastrointestinal Microbiome physiology, Lactulose therapeutic use, Mannitol therapeutic use, Multiple Sclerosis, Relapsing-Remitting drug therapy
Abstract

Background: Alterations of intestinal permeability (IP) may contribute to the pathophysiology of immune-mediated diseases., Objective: We investigated the possible association between IP changes and multiple sclerosis (MS)., Methods: We studied 22 patients with relapsing-remitting multiple sclerosis (RRMS) and 18 age- and sex-matched healthy donors (HDs), including five twin pairs (one concordant, and four discordant for disease). Measurement of lactulose (L) and mannitol (M; two non-metabolized sugars) levels in urine samples, after an oral load, allowed to quantify gut dysfunction., Results: The proportion of participants with increased IP was significantly higher in patients than in HDs (16/22 (73%) versus 5/18 (28%); p = 0.001). Accordingly, the L/M urinary ratio showed significantly higher values in patients than in controls ( p = 0.0284). Urinary mannitol concentration was significantly lower in patients than in controls ( p = 0.022), suggesting a deficit of absorption from intestinal lumen. Such changes did not appear related to patients' clinical-radiological features., Conclusion: The relatively high proportion of IP changes in RR-MS patients seems to confirm our work hypothesis and warrants more work to confirm the result on a larger sample, and to understand the implications for related immunological disturbances and intestinal microbiota alterations. Our finding may also have relevance for oral treatments, recently introduced in clinical practice.

Published
2017
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