29 results on '"Forestieri, Valeria"'
Search Results
2. Fluorouracil and dose-dense adjuvant chemotherapy in patients with early-stage breast cancer (GIM2): end-of-study results from a randomised, phase 3 trial
- Author
-
Venturini, M, Abate, A, Pastorino, S, Canavese, G, Vecchio, C, Guenzi, M, Lambertini, M, Levaggi, A, Giraudi, S, Accortanzo, V, Floris, C.A., Aitini, E, Fornari, G, Miraglia, S, Buonfanti, G, Cherchi, M.C., Petrelli, F, Vaccaro, A, Magnolfi, E, Contu, A, Labianca, R, Parisi, A, Basurto, C, Cappuzzo, F, Merlano, M, Russo, S, Mansutti, M, Poletto, E, Nardi, M, Grasso, D, Fontana, A, Isa, L, Comandè, M, Cavanna, L, Iacobelli, S, Milani, S, Mustacchi, G, Venturini, S, Scinto, A.F., Sarobba, M.G., Pugliese, P, Bernardo, A, Pavese, I, Coccaro, M, Massidda, B, Ionta, M.T., Nuzzo, A, Laudadio, L, Chiantera, V, Dottori, R, Barduagni, M, Castiglione, F, Ciardiello, F, Tinessa, V, Ficorella, A, Moscetti, L, Vallini, I, Giardina, G, Silva, R, Montedoro, M, Seles, E, Morano, F, Cruciani, G, Adamo, V, Pancotti, A, Palmisani, V, Ruggeri, A, Cammilluzzi, E, Carrozza, F, D'Aprile, M, Brunetti, M, Gallotti, P, Chiesa, E, Testore, F, D'Arco, A, Ferro, A, Jirillo, A, Pezzoli, M, Scambia, G, Iacono, C, Masullo, P, Tomasello, G, Gandini, G, Zoboli, A, Bottero, C, Cazzaniga, M, Genua, G, Palazzo, S, D'Amico, M, Perrone, D, Del Mastro, Lucia, Poggio, Francesca, Blondeaux, Eva, De Placido, Sabino, Giuliano, Mario, Forestieri, Valeria, De Laurentiis, Michelino, Gravina, Adriano, Bisagni, Giancarlo, Rimanti, Anita, Turletti, Anna, Nisticò, Cecilia, Vaccaro, Angela, Cognetti, Francesco, Fabi, Alessandra, Gasparro, Simona, Garrone, Ornella, Alicicco, Maria Grazia, Urracci, Ylenia, Mansutti, Mauro, Poletti, Paola, Correale, Pierpaolo, Bighin, Claudia, Puglisi, Fabio, Montemurro, Filippo, Colantuoni, Giuseppe, Lambertini, Matteo, and Boni, Luca
- Published
- 2022
- Full Text
- View/download PDF
3. Optimising triage procedures for patients with cancer needing active anticancer treatment in the COVID-19 era
- Author
-
Arpino, Grazia, De Angelis, Carmine, De Placido, Pietro, Pietroluongo, Erica, Formisano, Luigi, Bianco, Roberto, Fiore, Giovanni, Montella, Emma, Forestieri, Valeria, Lauria, Rossella, Cardalesi, Cinzia, Vozzella, Emilia Anna, Iervolino, Anna, Giuliano, Mario, and De Placido, Sabino
- Published
- 2020
- Full Text
- View/download PDF
4. Pretreatment Serum Concentration of Vitamin D and Breast Cancer Characteristics: A Prospective Observational Mediterranean Study
- Author
-
Buono, Giuseppe, Giuliano, Mario, De Angelis, Carmine, Lauria, Rossella, Forestieri, Valeria, Pensabene, Matilde, Bruzzese, Dario, De Placido, Sabino, and Arpino, Grazia
- Published
- 2017
- Full Text
- View/download PDF
5. Carboplatin and paclitaxel plus avelumab compared with carboplatin and paclitaxel in advanced or recurrent endometrial cancer (MITO END-3): a multicentre, open-label, randomised, controlled, phase 2 trial
- Author
-
Pignata, Sandro, primary, Scambia, Giovanni, additional, Schettino, Clorinda, additional, Arenare, Laura, additional, Pisano, Carmela, additional, Lombardi, Davide, additional, De Giorgi, Ugo, additional, Andreetta, Claudia, additional, Cinieri, Saverio, additional, De Angelis, Carmine, additional, Priolo, Domenico, additional, Casanova, Claudia, additional, Rosati, Marta, additional, Greco, Filippo, additional, Zafarana, Elena, additional, Schiavetto, Ilaria, additional, Mammoliti, Serafina, additional, Cecere, Sabrina Chiara, additional, Salutari, Vanda, additional, Scalone, Simona, additional, Farolfi, Alberto, additional, Di Napoli, Marilena, additional, Lorusso, Domenica, additional, Gargiulo, Piera, additional, Califano, Daniela, additional, Russo, Daniela, additional, Spina, Anna, additional, De Cecio, Rossella, additional, Chiodini, Paolo, additional, Perrone, Francesco, additional, Accinno, Valentina, additional, Altavilla, Chiara, additional, Antonelli, Giovanna, additional, Artioli, Grazia, additional, Avola, Francesco, additional, Barbara, Bonifacio, additional, Barbato, Valentina, additional, Bartoletti, Michele, additional, Bevilacqua, Simona, additional, Bordonaro, Roberto, additional, Borghese, Oriana, additional, Buonfanti, Gaetano, additional, Camarda, Floriana, additional, Canzanella, Giuliana, additional, Carbone, Vittoria, additional, Carbone, Maria Rita, additional, Carlo Stella, Giulia, additional, Cassani, Chiara, additional, Castagna, Fabrizio, additional, Cattaneo, Monica, additional, Cinefra, Margherita, additional, Colombo, Nicoletta, additional, Corsetti, Serena, additional, Dall'Agata, Monia, additional, D'Amico, Maria, additional, Daniele, Gennaro, additional, De Marino, Elvira, additional, De Matteis, Giovanni, additional, De Placido, Sabino, additional, Del Bene, Gabriella, additional, Del Giudice, Antonia, additional, Del Monte, Francesca, additional, Del Sesto, Michele, additional, Donini, Maddalena, additional, Drudi, Giuliana, additional, Falcone, Gianluca, additional, Favaretto, Adolfo, additional, Ferrera, Giulia, additional, Florio, Manuela, additional, Forestieri, Valeria, additional, Gallo, Maria Stella, additional, Gallo, Ciro, additional, Garibaldi, Francesca, additional, Gerevini, Fabiana, additional, Ghizzoni, Viola, additional, Giganti, Maria Olga, additional, Gimigliano, Anna, additional, Giudice, Elena, additional, Gnocchi, Nicoletta, additional, Gravina, Adriano, additional, Greggi, Stefano, additional, Iaia, Maria Laura, additional, Ilardi, Annalisa, additional, Iovine, Gelsomina, additional, Ippoliti, Gabriella, additional, Irollo, Giulia, additional, Isidori, Ilenia, additional, Lapresa, Mariateresa, additional, Lavenia, Giuseppe, additional, Longhitano, Laura, additional, Lucia, Bortot, additional, Luzi, Gabriella, additional, Mariano, Sara, additional, Marino, Valentina, additional, Marrapese, Giovanna, additional, Martino, Marilena, additional, Matocci, Roberta, additional, Mazzoni, Enrica, additional, Mercuri, Daniela, additional, Mirto, Maria, additional, Mollo, Giovanna, additional, Montinaro, Abbondanza, additional, Moscatelli, Marta, additional, Mosconi, Anna Maria, additional, Musacchio, Lucia, additional, Nanni, Nicoletta, additional, Natalucci, Pamela, additional, Nicoloso, Milena Sabrina, additional, Orditura, Michele, additional, Parma, Gabriella Maria, additional, Passalacqua, Rodolfo, additional, Pelone, Michela, additional, Perri, Maria Teresa, additional, Perrucci, Bruno, additional, Piancastelli, Alessandra, additional, Piccirillo, Maria Carmela, additional, Piccolo, Antonio, additional, Pignata, Sandro, additional, Rapisardi, Stefania, additional, Ravaglia, Giorgia, additional, Ribecco, Teresa, additional, Ricci, Caterina, additional, Roccio, Marianna, additional, Romano, Fiorella, additional, Sambataro, Daniela, additional, Savio, Alfonso, additional, Sbriglia, Ada, additional, Scaffa, Cono, additional, Sergi, Concetta, additional, Sgandurra, Francesca, additional, Sorio, Roberto, additional, Stabile, Stefano, additional, Tabaro, Gianna, additional, Tambaro, Margherita, additional, Tamberi, Stefano, additional, Tecchiato, Angelica, additional, Trujillo, Angela Maria, additional, and Zaccarelli, Eleonora, additional
- Published
- 2023
- Full Text
- View/download PDF
6. Fluorouracil and dose-dense chemotherapy in adjuvant treatment of patients with early-stage breast cancer: an open-label, 2 × 2 factorial, randomised phase 3 trial
- Author
-
Del Mastro, Lucia, De Placido, Sabino, Bruzzi, Paolo, De Laurentiis, Michele, Boni, Corrado, Cavazzini, Giovanna, Durando, Antonio, Turletti, Anna, Nisticò, Cecilia, Valle, Enrichetta, Garrone, Ornella, Puglisi, Fabio, Montemurro, Filippo, Barni, Sandro, Ardizzoni, Andrea, Gamucci, Teresa, Colantuoni, Giuseppe, Giuliano, Mario, Gravina, Adriano, Papaldo, Paola, Bighin, Claudia, Bisagni, Giancarlo, Forestieri, Valeria, and Cognetti, Francesco
- Published
- 2015
- Full Text
- View/download PDF
7. Fluorouracil and dose-dense adjuvant chemotherapy in patients with early-stage breast cancer (GIM2): end-of-study results from a randomised, phase 3 trial
- Author
-
Del Mastro, Lucia, primary, Poggio, Francesca, additional, Blondeaux, Eva, additional, De Placido, Sabino, additional, Giuliano, Mario, additional, Forestieri, Valeria, additional, De Laurentiis, Michelino, additional, Gravina, Adriano, additional, Bisagni, Giancarlo, additional, Rimanti, Anita, additional, Turletti, Anna, additional, Nisticò, Cecilia, additional, Vaccaro, Angela, additional, Cognetti, Francesco, additional, Fabi, Alessandra, additional, Gasparro, Simona, additional, Garrone, Ornella, additional, Alicicco, Maria Grazia, additional, Urracci, Ylenia, additional, Mansutti, Mauro, additional, Poletti, Paola, additional, Correale, Pierpaolo, additional, Bighin, Claudia, additional, Puglisi, Fabio, additional, Montemurro, Filippo, additional, Colantuoni, Giuseppe, additional, Lambertini, Matteo, additional, Boni, Luca, additional, Venturini, M, additional, Abate, A, additional, Pastorino, S, additional, Canavese, G, additional, Vecchio, C, additional, Guenzi, M, additional, Lambertini, M, additional, Levaggi, A, additional, Giraudi, S, additional, Accortanzo, V, additional, Floris, C.A., additional, Aitini, E, additional, Fornari, G, additional, Miraglia, S, additional, Buonfanti, G, additional, Cherchi, M.C., additional, Petrelli, F, additional, Vaccaro, A, additional, Magnolfi, E, additional, Contu, A, additional, Labianca, R, additional, Parisi, A, additional, Basurto, C, additional, Cappuzzo, F, additional, Merlano, M, additional, Russo, S, additional, Mansutti, M, additional, Poletto, E, additional, Nardi, M, additional, Grasso, D, additional, Fontana, A, additional, Isa, L, additional, Comandè, M, additional, Cavanna, L, additional, Iacobelli, S, additional, Milani, S, additional, Mustacchi, G, additional, Venturini, S, additional, Scinto, A.F., additional, Sarobba, M.G., additional, Pugliese, P, additional, Bernardo, A, additional, Pavese, I, additional, Coccaro, M, additional, Massidda, B, additional, Ionta, M.T., additional, Nuzzo, A, additional, Laudadio, L, additional, Chiantera, V, additional, Dottori, R, additional, Barduagni, M, additional, Castiglione, F, additional, Ciardiello, F, additional, Tinessa, V, additional, Ficorella, A, additional, Moscetti, L, additional, Vallini, I, additional, Giardina, G, additional, Silva, R, additional, Montedoro, M, additional, Seles, E, additional, Morano, F, additional, Cruciani, G, additional, Adamo, V, additional, Pancotti, A, additional, Palmisani, V, additional, Ruggeri, A, additional, Cammilluzzi, E, additional, Carrozza, F, additional, D'Aprile, M, additional, Brunetti, M, additional, Gallotti, P, additional, Chiesa, E, additional, Testore, F, additional, D'Arco, A, additional, Ferro, A, additional, Jirillo, A, additional, Pezzoli, M, additional, Scambia, G, additional, Iacono, C, additional, Masullo, P, additional, Tomasello, G, additional, Gandini, G, additional, Zoboli, A, additional, Bottero, C, additional, Cazzaniga, M, additional, Genua, G, additional, Palazzo, S, additional, D'Amico, M, additional, and Perrone, D, additional
- Published
- 2022
- Full Text
- View/download PDF
8. Insight on the Role of Leptin: A Bridge from Obesity to Breast Cancer
- Author
-
Buonaiuto, Roberto, primary, Napolitano, Fabiana, additional, Parola, Sara, additional, De Placido, Pietro, additional, Forestieri, Valeria, additional, Pecoraro, Giovanna, additional, Servetto, Alberto, additional, Formisano, Luigi, additional, Formisano, Pietro, additional, Giuliano, Mario, additional, Arpino, Grazia, additional, De Placido, Sabino, additional, and De Angelis, Carmine, additional
- Published
- 2022
- Full Text
- View/download PDF
9. Metabolic and anthropometric changes in early breast cancer patients receiving adjuvant therapy
- Author
-
Arpino, Grazia, De Angelis, Carmine, Buono, Giuseppe, Colao, Annamaria, Giuliano, Mario, Malgieri, Simona, Cicala, Stefania, De Laurentiis, Michelino, Accurso, Antonello, Crispo, Anna, Limite, Gennaro, Lauria, Rossella, Veneziani, Bianca Maria, Forestieri, Valeria, Bruzzese, Dario, and De Placido, Sabino
- Published
- 2015
- Full Text
- View/download PDF
10. Case Report: Detection of a Novel Germline PALB2 Deletion in a Young Woman With Hereditary Breast Cancer: When the Patient's Phenotype History Doesn't Lie
- Author
-
De Angelis, Carmine, primary, Nardelli, Carmela, additional, Concolino, Paola, additional, Pagliuca, Martina, additional, Setaro, Mario, additional, De Paolis, Elisa, additional, De Placido, Pietro, additional, Forestieri, Valeria, additional, Scaglione, Giovanni Luca, additional, Ranieri, Annalisa, additional, Lombardo, Barbara, additional, Pastore, Lucio, additional, De Placido, Sabino, additional, and Capoluongo, Ettore, additional
- Published
- 2021
- Full Text
- View/download PDF
11. Eribulin in combination with bevacizumab as second-line treatment for HER2–negative metastatic breast cancer progressing after first-line therapy with paclitaxel and bevacizumab: a multicenter, phase II, single arm trial (GIM11-BERGI)
- Author
-
DE ANGELIS, CARMINE, primary, Bruzzese, Dario, additional, Bernardo, Antonio, additional, Baldini, Editta, additional, Leo, Luigi, additional, Fabi, Alessandra, additional, Gamucci, Teresa, additional, De Placido, Pietro, additional, Poggio, Francesca, additional, Russo, Stefania, additional, Forestieri, Valeria, additional, Lauria, Rossella, additional, De Santo, Irene, additional, Michelotti, Andrea, additional, Mastro, Lucia Del, additional, De Laurentiis, Michelino, additional, Giuliano, Mario, additional, De Placido, Sabino, additional, and Arpino, Grazia, additional
- Published
- 2020
- Full Text
- View/download PDF
12. Metabolic syndrome and early stage breast cancer outcome: results from a prospective observational study
- Author
-
Buono, Giuseppe, primary, Crispo, Anna, additional, Giuliano, Mario, additional, De Angelis, Carmine, additional, Schettini, Francesco, additional, Forestieri, Valeria, additional, Lauria, Rossella, additional, De Laurentiis, Michelino, additional, De Placido, Pietro, additional, Rea, Carmen Giusy, additional, Pacilio, Carmen, additional, Esposito, Emanuela, additional, Grimaldi, Maria, additional, Nocerino, Flavia, additional, Porciello, Giuseppe, additional, Giudice, Aldo, additional, Amore, Alfonso, additional, Minopoli, Anita, additional, Botti, Gerardo, additional, De Placido, Sabino, additional, Trivedi, Meghana V., additional, and Arpino, Grazia, additional
- Published
- 2020
- Full Text
- View/download PDF
13. Palbociclib added to ongoing endocrine therapy for hormone receptor‑positive HER2‑negative metastatic breast cancer: A case report series
- Author
-
Schettini, Francesco, primary, De Santo, Irene, additional, Rea, Carmen, additional, Viggiani, Martina, additional, Buono, Giuseppe, additional, De Angelis, Carmine, additional, Cardalesi, Cinzia, additional, Lauria, Rossella, additional, Giuliano, Mario, additional, Forestieri, Valeria, additional, Thomas, Guglielmo, additional, Maione, Pierfrancesco, additional, Limite, Gennaro, additional, Accurso, Antonello, additional, Malorni, Luca, additional, De Placido, Sabino, additional, and Arpino, Grazia, additional
- Published
- 2020
- Full Text
- View/download PDF
14. Adjuvant zoledronic acid and letrozole plus ovarian function suppression in premenopausal breast cancer: HOBOE phase 3 randomised trial
- Author
-
Perrone, Francesco, primary, De Laurentiis, Michelino, additional, De Placido, Sabino, additional, Orditura, Michele, additional, Cinieri, Saverio, additional, Riccardi, Ferdinando, additional, Ribecco, Angela Stefania, additional, Putzu, Carlo, additional, Del Mastro, Lucia, additional, Rossi, Emanuela, additional, Tinessa, Vincenza, additional, Mosconi, Anna Maria, additional, Nuzzo, Francesco, additional, Di Rella, Francesca, additional, Gravina, Adriano, additional, Iodice, Giovanni, additional, Landi, Gabriella, additional, Pacilio, Carmen, additional, Forestieri, Valeria, additional, Lauria, Rossella, additional, Fabbri, Agnese, additional, Ibrahim, Toni, additional, De Maio, Ermelinda, additional, Barni, Sandro, additional, Gori, Stefania, additional, Simeon, Vittorio, additional, Arenare, Laura, additional, Daniele, Gennaro, additional, Piccirillo, Maria Carmela, additional, Normanno, Nicola, additional, de Matteis, Andrea, additional, and Gallo, Ciro, additional
- Published
- 2019
- Full Text
- View/download PDF
15. Adjuvant anastrozole versus exemestane versus letrozole, upfront or after 2 years of tamoxifen, in endocrine-sensitive breast cancer (FATA-GIM3): a randomised, phase 3 trial
- Author
-
De Placido, Sabino, primary, Gallo, Ciro, additional, De Laurentiis, Michelino, additional, Bisagni, Giancarlo, additional, Arpino, Grazia, additional, Sarobba, Maria Giuseppa, additional, Riccardi, Ferdinando, additional, Russo, Antonio, additional, Del Mastro, Lucia, additional, Cogoni, Alessio Aligi, additional, Cognetti, Francesco, additional, Gori, Stefania, additional, Foglietta, Jennifer, additional, Frassoldati, Antonio, additional, Amoroso, Domenico, additional, Laudadio, Lucio, additional, Moscetti, Luca, additional, Montemurro, Filippo, additional, Verusio, Claudio, additional, Bernardo, Antonio, additional, Lorusso, Vito, additional, Gravina, Adriano, additional, Moretti, Gabriella, additional, Lauria, Rossella, additional, Lai, Antonella, additional, Mocerino, Carmela, additional, Rizzo, Sergio, additional, Nuzzo, Francesco, additional, Carlini, Paolo, additional, Perrone, Francesco, additional, Accurso, Antonello, additional, Agostara, Biagio, additional, Aieta, Michele, additional, Alabiso, Oscar, additional, Alicicco, Maria Grazia, additional, Amadori, Dino, additional, Amaducci, Laura, additional, Amiconi, Gianna, additional, Antuzzi, Giustino, additional, Ardine, Mara, additional, Ardizzoia, Antonio, additional, Aversa, Caterina, additional, Badalamenti, Giuseppe, additional, Barni, Sandro, additional, Basurto, Carlo, additional, Berardi, Rossana, additional, Bergamasco, Cinzia, additional, Bidoli, Paolo, additional, Bighin, Claudia, additional, Biondi, Edoardo, additional, Boni, Corrado, additional, Borgonovo, Karen, additional, Botta, Mario, additional, Bravi, Stefano, additional, Bruzzi, Paolo, additional, Buono, Giuseppe, additional, Butera, Alfredo, additional, Caldara, Alessia, additional, Candeloro, Giampiero, additional, Cappelletti, Claudia, additional, Cardalesi, Cinzia, additional, Carfora, Elisabetta, additional, Cariello, Anna, additional, Carrozza, Francesco, additional, Cartenì, Giacomo, additional, Caruso, Michele, additional, Casadei, Virginia, additional, Casanova, Claudia, additional, Castori, Luigi, additional, Cavanna, Luigi, additional, Cavazzini, Giovanna, additional, Cazzaniga, Marina, additional, Chilelli, Mario, additional, Chiodini, Paolo, additional, Chiorrini, Silvia, additional, Ciardiello, Fortunato, additional, Ciccarese, Mariangela, additional, Cinieri, Saverio, additional, Clerico, Mario, additional, Coccaro, Mariarosa, additional, Comande, Mario, additional, Corbo, Claudia, additional, Cortino, Giuseppina, additional, Cusenza, Stefania, additional, Daniele, Gennaro, additional, D'arco, Alfonso Maria, additional, D'auria, Giuliana, additional, Dazzi, Claudio, additional, De Angelis, Carmine, additional, de Braud, Filippo, additional, De Feo, Gianfranco, additional, De Matteis, Andrea, additional, De Tursi, Michele, additional, Di Blasio, Anna, additional, di Lucca, Giuseppe, additional, Di Lullo, Liberato, additional, Di Rella, Francesca, additional, Di Renzo, Gianfranco, additional, Di Stefano, Pia, additional, Di Stefano, Aida, additional, Diana, Anna, additional, Donati, Sara, additional, Fabbri, Agnese, additional, Fabi, Alessandra, additional, Faedi, Marina, additional, Farina, Gabriella, additional, Farris, Antonio, additional, Febbraro, Antonio, additional, Fedele, Palma, additional, Federico, Piera, additional, Ferraù, Francesco, additional, Ferretti, Gianluigi, additional, Ferro, Antonella, additional, Floriani, Irene, additional, Forcignanò, Rosachiara, additional, Forciniti, Samantha, additional, Forestieri, Valeria, additional, Fornari, Gianni, additional, Frisinghelli, Michela, additional, Fusco, Vittorio, additional, Gallizzi, Giulia, additional, Galvano, Antonio, additional, Gambardella, Antonio, additional, Gambi, Angelo, additional, Gebbia, Vittorio, additional, Gervasi, Erika, additional, Ghilardi, Mara, additional, Giacobino, Alice, additional, Giardina, Giovanni, additional, Giotta, Francesco, additional, Giraudi, Sara, additional, Giuliano, Mario, additional, Grassadonia, Antonino, additional, Grasso, Donatella, additional, Grosso, Federica, additional, Guizzaro, Lorenzo, additional, Incoronato, Pasquale, additional, Incorvaia, Lorena, additional, Iodice, Giovanni, additional, La Verde, Nicla, additional, Labonia, Vincenzo, additional, Landi, Gabriella, additional, Latorre, Agnese, additional, Leonardi, Vita, additional, Levaggi, Alessia, additional, Limite, Gennaro, additional, Lina Bascialla, Linda, additional, Livi, Lorenzo, additional, Maiello, Evaristo, additional, Mandelli, Daniela, additional, Marcon, Ilaria, additional, Menon, Daniela, additional, Montedoro, Michele, additional, Moraca, Lucia, additional, Moretti, Anna, additional, Morritti, Maria Grazia, additional, Morselli, Patrizia, additional, Mura, Antonella, additional, Mura, Silvia, additional, Musacchio, Michela, additional, Muzio, Alberto, additional, Natale, Donato, additional, Natoli, Clara, additional, Nigro, Cinzia, additional, Nisticò, Cecilia, additional, Nuzzo, Antonio, additional, Orditura, Michele, additional, Orlando, Laura, additional, Pacilio, Carmen, additional, Palumbo, Giuliano, additional, Palumbo, Raffaella, additional, Pasini, Felice, additional, Paterno, Emanuela, additional, Pazzola, Antonio, additional, Pelliccioni, Silvia, additional, Pensabene, Matilde, additional, Perroni, Davide, additional, Pesenti Gritti, Angela, additional, Petrelli, Fausto, additional, Piccirillo, Maria Carmela, additional, Pinotti, Graziella, additional, Pogliani, Claudia, additional, Poli, Davide, additional, Prader, Sonia, additional, Recchia, Francesco, additional, Rizzi, Daniele, additional, Romano, Carmen, additional, Rossello, Rosalba, additional, Rossini, Chiara, additional, Salvucci, Giuseppina, additional, Sanna, Valeria, additional, Santini, Alessandra, additional, Saracchini, Silvana, additional, Savastano, Clementina, additional, Scambia, Giovanni, additional, Schettini, Francesco, additional, Schiavone, Paola, additional, Schirone, Alessio, additional, Seles, Elena, additional, Signoriello, Simona, additional, Signoriello, Giuseppe, additional, Silva, Rosa Rita, additional, Silvestri, Antonia, additional, Simeon, Vittorio, additional, Spagnoletti, Ilaria, additional, Tamberi, Stefano, additional, Teragni, Cristina, additional, Thalmann, Verena, additional, Thomas, Renato, additional, Thomas, Guglielmo, additional, Tienghi, Amelia, additional, Tinari, Nicola, additional, Tinessa, Vincenza, additional, Tomei, Federica, additional, Tonini, Giuseppe, additional, Torri, Valter, additional, Traficante, Divina, additional, Tudini, Marianna, additional, Turazza, Monica, additional, Vignoli, Roberto, additional, Vitale, Maria Giuseppa, additional, Zacchia, Alessandra, additional, Zagarese, Pasquale, additional, Zanni, Alda, additional, Zavallone, Laura, additional, Zavettieri, Maria, additional, and Zoboli, Alessandra, additional
- Published
- 2018
- Full Text
- View/download PDF
16. It is no longer the time to disregard thyroid metastases from breast cancer: a case report and review of the literature
- Author
-
Pensabene, Matilde, primary, Stanzione, Brigida, additional, Cerillo, Ivana, additional, Ciancia, Giuseppe, additional, Cozzolino, Immacolata, additional, Ruocco, Raffaella, additional, Condello, Caterina, additional, Di Lorenzo, Giuseppe, additional, Giuliano, Mario, additional, Forestieri, Valeria, additional, Arpino, Grazia, additional, De Placido, Sabino, additional, and Lauria, Rossella, additional
- Published
- 2018
- Full Text
- View/download PDF
17. Combined effect of obesity and diabetes on early breast cancer outcome: a prospective observational study
- Author
-
Buono, Giuseppe, primary, Crispo, Anna, additional, Giuliano, Mario, additional, De Angelis, Carmine, additional, Schettini, Francesco, additional, Forestieri, Valeria, additional, Lauria, Rossella, additional, Pensabene, Matilde, additional, De Laurentiis, Michelino, additional, Augustin, Livia Silvia Adriana, additional, Amore, Alfonso, additional, D’Aiuto, Massimiliano, additional, Tortoriello, Raffaele, additional, Accurso, Antonello, additional, Cavalcanti, Ernesta, additional, Botti, Gerardo, additional, Montella, Maurizio, additional, De Placido, Sabino, additional, and Arpino, Grazia, additional
- Published
- 2017
- Full Text
- View/download PDF
18. Long-term survival and BRCA status in male breast cancer: a retrospective single-center analysis
- Author
-
Gargiulo, Piera, primary, Pensabene, Matilde, additional, Milano, Monica, additional, Arpino, Grazia, additional, Giuliano, Mario, additional, Forestieri, Valeria, additional, Condello, Caterina, additional, Lauria, Rossella, additional, and De Placido, Sabino, additional
- Published
- 2016
- Full Text
- View/download PDF
19. Insight on the Role of Leptin: A Bridge from Obesity to Breast Cancer
- Author
-
Roberto Buonaiuto, Fabiana Napolitano, Sara Parola, Pietro De Placido, Valeria Forestieri, Giovanna Pecoraro, Alberto Servetto, Luigi Formisano, Pietro Formisano, Mario Giuliano, Grazia Arpino, Sabino De Placido, Carmine De Angelis, Buonaiuto, Roberto, Napolitano, Fabiana, Parola, Sara, De Placido, Pietro, Forestieri, Valeria, Pecoraro, Giovanna, Servetto, Alberto, Formisano, Luigi, Formisano, Pietro, Giuliano, Mario, Arpino, Grazia, De Placido, Sabino, and De Angelis, Carmine
- Subjects
Leptin ,obesity ,Breast Neoplasms ,Biochemistry ,Phosphatidylinositol 3-Kinases ,LEPR ,breast cancer ,Adipokines ,Adipokine ,Humans ,Female ,Phosphatidylinositol 3-Kinase ,Molecular Biology ,Proto-Oncogene Proteins c-akt ,Human - Abstract
Leptin is a peptide hormone, mainly known for its role as a mediator of adipose tissue endocrine functions, such as appetite control and energy homeostasis. In addition, leptin signaling is involved in several physiological processes as modulation of innate and adaptive immune responses and regulation of sex hormone levels. When adipose tissue expands, an imbalance of adipokines secretion may occur and increasing leptin levels contribute to promoting a chronic inflammatory state, which is largely acknowledged as a hallmark of cancer. Indeed, upon binding its receptor (LEPR), leptin activates several oncogenic pathways, such as JAK/STAT, MAPK, and PI3K/AKT, and seems to affect cancer immune response by inducing a proinflammatory immune polarization and eventually enhancing T-cell exhaustion. In particular, obesity-associated hyperleptinemia has been related to breast cancer risk development, although the underlying mechanism is yet to be completely clarified and needs to be deemed in light of multiple variables, such as menopausal state and immune response. The aim of this review is to provide an overview of the potential role of leptin as a bridge between obesity and breast cancer and to establish the physio-pathological basis of the linkage between these major health concerns in order to identify appropriate and novel therapeutic strategies to adopt in daily clinical practice.
- Published
- 2022
20. Case Report: Detection of a Novel Germline PALB2 Deletion in a Young Woman With Hereditary Breast Cancer: When the Patient's Phenotype History Doesn't Lie
- Author
-
Carmine De Angelis, Carmela Nardelli, Paola Concolino, Martina Pagliuca, Mario Setaro, Elisa De Paolis, Pietro De Placido, Valeria Forestieri, Giovanni Luca Scaglione, Annalisa Ranieri, Barbara Lombardo, Lucio Pastore, Sabino De Placido, Ettore Capoluongo, De Angelis, Carmine, Nardelli, Carmela, Concolino, Paola, Pagliuca, Martina, Setaro, Mario, De Paolis, Elisa, De Placido, Pietro, Forestieri, Valeria, Scaglione, Giovanni Luca, Ranieri, Annalisa, Lombardo, Barbara, Pastore, Lucio, De Placido, Sabino, and Capoluongo, Ettore
- Subjects
Cancer Research ,Mutation ,breast-cancer risk ,business.industry ,PALB2 ,Case Report ,hereditary breast cancer ,medicine.disease ,medicine.disease_cause ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,PALB2 Gene ,lcsh:RC254-282 ,Germline ,Exon ,Breast cancer ,Oncology ,Cancer research ,surveillance ,Medicine ,deletion ,Family history ,business ,Homologous recombination ,skin and connective tissue diseases - Abstract
The partner and localizer of BRCA2 (PALB2) is a major BRCA2 binding partner that participates in homologous recombination repair in response to DNA double-strand breaks. Germline alterations of the PALB2 gene have recently been associated with a high risk of developing breast cancer. We investigated a 37-year-old Caucasian woman with breast cancer and family history of breast cancer using targeted next generation sequencing. A novel heterozygous deletion involving exons 5 and 6 was found in the PALB2 gene, and resulted in the production of a truncated PALB2 protein. These findings expand the mutational spectra of PALB2-associated breast cancer, and may improve the mutation-based screening and genetic diagnosis of breast cancer.
- Published
- 2021
21. Adjuvant zoledronic acid and letrozole plus ovarian function suppression in premenopausal breast cancer: HOBOE phase 3 randomised trial
- Author
-
Emanuela Rossi, Francesca Di Rella, Carlo Putzu, Francesco Perrone, Rossella Lauria, Lucia Del Mastro, Gennaro Daniele, Vittorio Simeon, Vincenza Tinessa, Ermelinda De Maio, Sabino De Placido, G. Landi, Sandro Barni, Francesco Nuzzo, Saverio Cinieri, Giovanni Iodice, Andrea de Matteis, Nicola Normanno, A. Fabbri, Carmen Pacilio, Laura Arenare, Maria Carmela Piccirillo, Toni Ibrahim, Valeria Forestieri, Angela Stefania Ribecco, Adriano Gravina, Ciro Gallo, Stefania Gori, Anna Maria Mosconi, Ferdinando Riccardi, Michele Orditura, Michelino De Laurentiis, Perrone, Francesco, De Laurentiis, Michelino, De Placido, Sabino, Orditura, Michele, Cinieri, Saverio, Riccardi, Ferdinando, Ribecco, Angela Stefania, Putzu, Carlo, Del Mastro, Lucia, Rossi, Emanuela, Tinessa, Vincenza, Mosconi, Anna Maria, Nuzzo, Francesco, Di Rella, Francesca, Gravina, Adriano, Iodice, Giovanni, Landi, Gabriella, Pacilio, Carmen, Forestieri, Valeria, Lauria, Rossella, Fabbri, Agnese, Ibrahim, Toni, De Maio, Ermelinda, Barni, Sandro, Gori, Stefania, Simeon, Vittorio, Arenare, Laura, Daniele, Gennaro, Piccirillo, Maria Carmela, Normanno, Nicola, de Matteis, Andrea, Gallo, Ciro, Perrone, F., De Laurentiis, M., De Placido, S., Orditura, M., Cinieri, S., Riccardi, F., Ribecco, A. S., Putzu, C., Del Mastro, L., Rossi, E., Tinessa, V., Mosconi, A. M., Nuzzo, F., Di Rella, F., Gravina, A., Iodice, G., Landi, G., Pacilio, C., Forestieri, V., Lauria, R., Fabbri, A., Ibrahim, T., De Maio, E., Barni, S., Gori, S., Simeon, V., Arenare, L., Daniele, G., Piccirillo, M. C., Normanno, N., de Matteis, A., and Gallo, C.
- Subjects
0301 basic medicine ,Cancer Research ,Time Factors ,Gastroenterology ,Zoledronic Acid ,0302 clinical medicine ,Breast cancer ,Antineoplastic Combined Chemotherapy Protocols ,education.field_of_study ,Triptorelin Pamoate ,Bone Density Conservation Agents ,Aromatase Inhibitors ,Letrozole ,Hazard ratio ,Estrogen Antagonists ,Middle Aged ,Triptorelin ,Oncology ,Italy ,Chemotherapy, Adjuvant ,030220 oncology & carcinogenesis ,Adjuvant endocrine treatment, Aromatase inhibitors, Breast cancer, Phase 3, Premenopausal patients, Zoledronic acid ,Disease Progression ,Female ,medicine.drug ,Adult ,medicine.medical_specialty ,Population ,Breast Neoplasms ,Phase 3 ,Adjuvant endocrine treatment ,Disease-Free Survival ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,education ,Premenopausal patients ,business.industry ,Ovary ,Premenopausal patient ,Cancer ,Aromatase inhibitor ,medicine.disease ,Tamoxifen ,030104 developmental biology ,Zoledronic acid ,Premenopause ,business - Abstract
Aim The aim of the study is to analyse whether letrozole (L) and zoledronic acid plus L (ZL) are more effective than tamoxifen (T) as adjuvant endocrine treatment of premenopausal patients with breast cancer with hormone receptor–positive (HR+) tumours. Patients and methods In a phase 3 trial, 1065 premenopausal patients with HR + early breast cancer received triptorelin to suppress ovarian function and were randomly assigned (1:1:1) to adjuvant T, L or ZL for 5 years. Cancer recurrence, second breast or non-breast cancer and death were considered events for the intention-to-treat disease-free survival (DFS) analysis. Results With a 64-month median follow-up and 134 reported events, the disease-free rate at 5 years was 85.4%, 93.2% and 93.3% with T, L and ZL, respectively (overall P = 0.008). The hazard ratio for a DFS event was 0.52 (95% confidence interval [CI], 0.34 to 0.80; P = 0.003) with ZL vs T, 0.72 (95% CI, 0.48 to 1.07; P = 0.06) with L vs T and 0.70 (95% CI, 0.44 to 1.12; P = 0.22) with ZL vs L. With 36 deaths, there was no significant difference in overall survival (P = 0.14). Treatment was stopped for toxicity or refusal in 7.3%, 7.3% and 16.6% patients, and in the safety population, grade 3–4 side-effects were reported in 4.2%, 6.9% and 9.1% patients treated with T, L or ZL, respectively. Conclusion HOBOE study shows that in premenopausal patients with early breast cancer undergoing ovarian function suppression with triptorelin, ZL significantly improves DFS, while worsening compliance and toxicity, as compared with T. ( NCT00412022 )
- Published
- 2019
22. Adjuvant anastrozole versus exemestane versus letrozole, upfront or after 2 years of tamoxifen, in endocrine-sensitive breast cancer (FATA-GIM3): a randomised, phase 3 trial
- Author
-
Sabino De Placido, Ciro Gallo, Michelino De Laurentiis, Giancarlo Bisagni, Grazia Arpino, Maria Giuseppa Sarobba, Ferdinando Riccardi, Antonio Russo, Lucia Del Mastro, Alessio Aligi Cogoni, Francesco Cognetti, Stefania Gori, Jennifer Foglietta, Antonio Frassoldati, Domenico Amoroso, Lucio Laudadio, Luca Moscetti, Filippo Montemurro, Claudio Verusio, Antonio Bernardo, Vito Lorusso, Adriano Gravina, Gabriella Moretti, Rossella Lauria, Antonella Lai, Carmela Mocerino, Sergio Rizzo, Francesco Nuzzo, Paolo Carlini, Francesco Perrone, Antonello Accurso, Biagio Agostara, Michele Aieta, Oscar Alabiso, Maria Grazia Alicicco, Dino Amadori, Laura Amaducci, Gianna Amiconi, Giustino Antuzzi, Mara Ardine, Antonio Ardizzoia, Caterina Aversa, Giuseppe Badalamenti, Sandro Barni, Carlo Basurto, Rossana Berardi, Cinzia Bergamasco, Paolo Bidoli, Claudia Bighin, Edoardo Biondi, Corrado Boni, Karen Borgonovo, Mario Botta, Stefano Bravi, Paolo Bruzzi, Giuseppe Buono, Alfredo Butera, Alessia Caldara, Giampiero Candeloro, Claudia Cappelletti, Cinzia Cardalesi, Elisabetta Carfora, Anna Cariello, Francesco Carrozza, Giacomo Cartenì, Michele Caruso, Virginia Casadei, Claudia Casanova, Luigi Castori, Luigi Cavanna, Giovanna Cavazzini, Marina Cazzaniga, Mario Chilelli, Paolo Chiodini, Silvia Chiorrini, Fortunato Ciardiello, Mariangela Ciccarese, Saverio Cinieri, Mario Clerico, Mariarosa Coccaro, Mario Comande, Claudia Corbo, Giuseppina Cortino, Stefania Cusenza, Gennaro Daniele, Alfonso Maria D'arco, Giuliana D'auria, Claudio Dazzi, Carmine De Angelis, Filippo de Braud, Gianfranco De Feo, Andrea De Matteis, Michele De Tursi, Anna Di Blasio, Giuseppe di Lucca, Liberato Di Lullo, Francesca Di Rella, Gianfranco Di Renzo, Pia Di Stefano, Aida Di Stefano, Anna Diana, Sara Donati, Agnese Fabbri, Alessandra Fabi, Marina Faedi, Gabriella Farina, Antonio Farris, Antonio Febbraro, Palma Fedele, Piera Federico, Francesco Ferraù, Gianluigi Ferretti, Antonella Ferro, Irene Floriani, Rosachiara Forcignanò, Samantha Forciniti, Valeria Forestieri, Gianni Fornari, Michela Frisinghelli, Vittorio Fusco, Giulia Gallizzi, Antonio Galvano, Antonio Gambardella, Angelo Gambi, Vittorio Gebbia, Erika Gervasi, Mara Ghilardi, Alice Giacobino, Giovanni Giardina, Francesco Giotta, Sara Giraudi, Mario Giuliano, Antonino Grassadonia, Donatella Grasso, Federica Grosso, Lorenzo Guizzaro, Pasquale Incoronato, Lorena Incorvaia, Giovanni Iodice, Nicla La Verde, Vincenzo Labonia, Gabriella Landi, Agnese Latorre, Vita Leonardi, Alessia Levaggi, Gennaro Limite, Linda Lina Bascialla, Lorenzo Livi, Evaristo Maiello, Daniela Mandelli, Ilaria Marcon, Daniela Menon, Michele Montedoro, Lucia Moraca, Anna Moretti, Maria Grazia Morritti, Patrizia Morselli, Antonella Mura, Silvia Mura, Michela Musacchio, Alberto Muzio, Donato Natale, Clara Natoli, Cinzia Nigro, Cecilia Nisticò, Antonio Nuzzo, Michele Orditura, Laura Orlando, Carmen Pacilio, Giuliano Palumbo, Raffaella Palumbo, Felice Pasini, Emanuela Paterno, Antonio Pazzola, Silvia Pelliccioni, Matilde Pensabene, Davide Perroni, Angela Pesenti Gritti, Fausto Petrelli, Maria Carmela Piccirillo, Graziella Pinotti, Claudia Pogliani, Davide Poli, Sonia Prader, Francesco Recchia, Daniele Rizzi, Carmen Romano, Rosalba Rossello, Chiara Rossini, Giuseppina Salvucci, Valeria Sanna, Alessandra Santini, Silvana Saracchini, Clementina Savastano, Giovanni Scambia, Francesco Schettini, Paola Schiavone, Alessio Schirone, Elena Seles, Simona Signoriello, Giuseppe Signoriello, Rosa Rita Silva, Antonia Silvestri, Vittorio Simeon, Ilaria Spagnoletti, Stefano Tamberi, Cristina Teragni, Verena Thalmann, Renato Thomas, Guglielmo Thomas, Amelia Tienghi, Nicola Tinari, Vincenza Tinessa, Federica Tomei, Giuseppe Tonini, Valter Torri, Divina Traficante, Marianna Tudini, Monica Turazza, Roberto Vignoli, Maria Giuseppa Vitale, Alessandra Zacchia, Pasquale Zagarese, Alda Zanni, Laura Zavallone, Maria Zavettieri, Alessandra Zoboli, De Placido, S., Gallo, C., De Laurentiis, M., Bisagni, G., Arpino, G., Sarobba, M. G., Riccardi, F., Russo, A., Del Mastro, L., Cogoni, A. A., Cognetti, F., Gori, S., Foglietta, J., Frassoldati, A., Amoroso, D., Laudadio, L., Moscetti, L., Montemurro, F., Verusio, C., Bernardo, A., Lorusso, V., Gravina, A., Moretti, G., Lauria, R., Lai, A., Mocerino, C., Rizzo, S., Nuzzo, F., Carlini, P., Perrone, F., Accurso, A., Agostara, B., Aieta, M., Alabiso, O., Alicicco, M. G., Amadori, D., Amaducci, L., Amiconi, G., Antuzzi, G., Ardine, M., Ardizzoia, A., Aversa, C., Badalamenti, G., Barni, S., Basurto, C., Berardi, R., Bergamasco, C., Bidoli, P., Bighin, C., Biondi, E., Boni, C., Borgonovo, K., Botta, M., Bravi, S., Bruzzi, P., Buono, G., Butera, A., Caldara, A., Candeloro, G., Cappelletti, C., Cardalesi, C., Carfora, E., Cariello, A., Carrozza, F., Carteni, G., Caruso, M., Casadei, V., Casanova, C., Castori, L., Cavanna, L., Cavazzini, G., Cazzaniga, M., Chilelli, M., Chiodini, P., Chiorrini, S., Ciardiello, F., Ciccarese, M., Cinieri, S., Clerico, M., Coccaro, M., Comande, M., Corbo, C., Cortino, G., Cusenza, S., Daniele, G., D'Arco, A. M., D'Auria, G., Dazzi, C., De Angelis, C., de Braud, F., De Feo, G., De Matteis, Ma., De Tursi, M., Di Blasio, A., di Lucca, G., Di Lullo, L., Di Rella, F., Di Renzo, G., Di Stefano, P., Di Stefano, A., Diana, A., Donati, S., Fabbri, A., Fabi, A., Faedi, M., Farina, G., Farris, A., Febbraro, A., Fedele, P., Federico, P., Ferrau, F., Ferretti, G., Ferro, A., Floriani, I., Forcignano, R., Forciniti, S., Forestieri, V., Fornari, G., Frisinghelli, M., Fusco, V., Gallizzi, G., Galvano, A., Gambardella, A., Gambi, A., Gebbia, V., Gervasi, E., Ghilardi, M., Giacobino, A., Giardina, G., Giotta, F., Giraudi, S., Giuliano, M., Grassadonia, A., Grasso, D., Grosso, F., Guizzaro, L., Incoronato, P., Incorvaia, L., Iodice, G., La Verde, N., Labonia, V., Landi, G., Latorre, A., Leonardi, V., Levaggi, A., Limite, G., Lina Bascialla, L., Livi, L., Maiello, E., Mandelli, D., Marcon, I., Menon, D., Montedoro, M., Moraca, L., Moretti, A., Morritti, M. G., Morselli, P., Mura, A., Mura, S., Musacchio, M., Muzio, A., Natale, D., Natoli, C., Nigro, C., Nistico, C., Nuzzo, A., Orditura, M., Orlando, L., Pacilio, C., Palumbo, G., Palumbo, R., Pasini, F., Paterno, E., Pazzola, A., Pelliccioni, S., Pensabene, M., Perroni, D., Pesenti Gritti, A., Petrelli, F., Piccirillo, M. C., Pinotti, G., Pogliani, C., Poli, D., Prader, S., Recchia, F., Rizzi, D., Romano, C., Rossello, R., Rossini, C., Salvucci, G., Sanna, V., Santini, A., Saracchini, S., Savastano, C., Scambia, G., Schettini, F., Schiavone, P., Schirone, A., Seles, E., Signoriello, S., Signoriello, G., Silva, R. R., Silvestri, A., Simeon, V., Spagnoletti, I., Tamberi, S., Teragni, C., Thalmann, V., Thomas, R., Thomas, G., Tienghi, A., Tinari, N., Tinessa, V., Tomei, F., Tonini, G., Torri, V., Traficante, D., Tudini, M., Turazza, M., Vignoli, R., Vitale, M. G., Zacchia, A., Zagarese, P., Zanni, A., Zavallone, L., Zavettieri, M., Zoboli, A., De Placido, Sabino, Gallo, Ciro, De Laurentiis, Michelino, Bisagni, Giancarlo, Arpino, Grazia, Sarobba, Maria Giuseppa, Riccardi, Ferdinando, Russo, Antonio, Del Mastro, Lucia, Cogoni, Alessio Aligi, Cognetti, Francesco, Gori, Stefania, Foglietta, Jennifer, Frassoldati, Antonio, Amoroso, Domenico, Laudadio, Lucio, Moscetti, Luca, Montemurro, Filippo, Verusio, Claudio, Bernardo, Antonio, Lorusso, Vito, Gravina, Adriano, Moretti, Gabriella, Lauria, Rossella, Lai, Antonella, Mocerino, Carmen, Rizzo, Sergio, Nuzzo, Francesco, Carlini, Paolo, Perrone, Francesco, Accurso, Antonello, Agostara, Biagio, Aieta, Michele, Alabiso, Oscar, Alicicco, Maria Grazia, Amadori, Dino, Amaducci, Laura, Amiconi, Gianna, Antuzzi, Giustino, Ardine, Mara, Ardizzoia, Antonio, Aversa, Caterina, Badalamenti, Giuseppe, Barni, Sandro, Basurto, Carlo, Berardi, Rossana, Bergamasco, Cinzia, Bidoli, Paolo, Bighin, Claudia, Biondi, Edoardo, Boni, Corrado, Borgonovo, Karen, Botta, Mario, Bravi, Stefano, Bruzzi, Paolo, Buono, Giuseppe, Butera, Alfredo, Caldara, Alessia, Candeloro, Giampiero, Cappelletti, Claudia, Cardalesi, Cinzia, Carfora, Elisabetta, Cariello, Anna, Carrozza, Francesco, Cartenì, Giacomo, Caruso, Michele, Casadei, Virginia, Casanova, Claudia, Castori, Luigi, Cavanna, Luigi, Cavazzini, Giovanna, Cazzaniga, Marina, Chilelli, Mario, Chiodini, Paolo, Chiorrini, Silvia, Ciardiello, Fortunato, Ciccarese, Mariangela, Cinieri, Saverio, Clerico, Mario, Coccaro, Mariarosa, Comande, Mario, Corbo, Claudia, Cortino, Giuseppina, Cusenza, Stefania, Daniele, Gennaro, D'arco, Alfonso Maria, D'auria, Giuliana, Dazzi, Claudio, De Angelis, Carmine, de Braud, Filippo, De Feo, Gianfranco, De Matteis, Andrea, De Tursi, Michele, Di Blasio, Anna, di Lucca, Giuseppe, Di Lullo, Liberato, Di Rella, Francesca, Di Renzo, Gianfranco, Di Stefano, Pia, Di Stefano, Aida, Diana, Anna, Donati, Sara, Fabbri, Agnese, Fabi, Alessandra, Faedi, Marina, Farina, Gabriella, Farris, Antonio, Febbraro, Antonio, Fedele, Palma, Federico, Piera, Ferraù, Francesco, Ferretti, Gianluigi, Ferro, Antonella, Floriani, Irene, Forcignanò, Rosachiara, Forciniti, Samantha, Forestieri, Valeria, Fornari, Gianni, Frisinghelli, Michela, Fusco, Vittorio, Gallizzi, Giulia, Galvano, Antonio, Gambardella, Antonio, Gambi, Angelo, Gebbia, Vittorio, Gervasi, Erika, Ghilardi, Mara, Giacobino, Alice, Giardina, Giovanni, Giotta, Francesco, Giraudi, Sara, Giuliano, Mario, Grassadonia, Antonino, Grasso, Donatella, Grosso, Federica, Guizzaro, Lorenzo, Incoronato, Pasquale, Incorvaia, Lorena, Iodice, Giovanni, La Verde, Nicla, Labonia, Vincenzo, Landi, Gabriella, Latorre, Agnese, Leonardi, Vita, Levaggi, Alessia, Limite, Gennaro, Lina Bascialla, Linda, Livi, Lorenzo, Maiello, Evaristo, Mandelli, Daniela, Marcon, Ilaria, Menon, Daniela, Montedoro, Michele, Moraca, Lucia, Moretti, Anna, Morritti, Maria Grazia, Morselli, Patrizia, Mura, Antonella, Mura, Silvia, Musacchio, Michela, Muzio, Alberto, Natale, Donato, Natoli, Clara, Nigro, Cinzia, Nisticò, Cecilia, Nuzzo, Antonio, Orditura, Michele, Orlando, Laura, Pacilio, Carmen, Palumbo, Giuliano, Palumbo, Raffaella, Pasini, Felice, Paterno, Emanuela, Pazzola, Antonio, Pelliccioni, Silvia, Pensabene, Matilde, Perroni, Davide, Pesenti Gritti, Angela, Petrelli, Fausto, Piccirillo, Maria Carmela, Pinotti, Graziella, Pogliani, Claudia, Poli, Davide, Prader, Sonia, Recchia, Francesco, Rizzi, Daniele, Romano, Carmen, Rossello, Rosalba, Rossini, Chiara, Salvucci, Giuseppina, Sanna, Valeria, Santini, Alessandra, Saracchini, Silvana, Savastano, Clementina, Scambia, Giovanni, Schettini, Francesco, Schiavone, Paola, Schirone, Alessio, Seles, Elena, Signoriello, Simona, Signoriello, Giuseppe, Silva, Rosa Rita, Silvestri, Antonia, Simeon, Vittorio, Spagnoletti, Ilaria, Tamberi, Stefano, Teragni, Cristina, Thalmann, Verena, Thomas, Renato, Thomas, Guglielmo, Tienghi, Amelia, Tinari, Nicola, Tinessa, Vincenza, Tomei, Federica, Tonini, Giuseppe, Torri, Valter, Traficante, Divina, Tudini, Marianna, Turazza, Monica, Vignoli, Roberto, Vitale, Maria Giuseppa, Zacchia, Alessandra, Zagarese, Pasquale, Zanni, Alda, Zavallone, Laura, Zavettieri, Maria, Zoboli, Alessandra, Mocerino, Carmela, D'Arco, Alfonso Maria, D'Auria, Giuliana, De Placido, S, Gallo, C, De Laurentiis, M, Bisagni, G, Arpino, G, Sarobba, M, Riccardi, F, Russo, A, Del Mastro, L, Cogoni, A, Cognetti, F, Gori, S, Foglietta, J, Frassoldati, A, Amoroso, D, Laudadio, L, Moscetti, L, Montemurro, F, Verusio, C, Bernardo, A, Lorusso, V, Gravina, A, Moretti, G, Lauria, R, Lai, A, Mocerino, C, Rizzo, S, Nuzzo, F, Carlini, P, Perrone, F, Accurso, A, Agostara, B, Aieta, M, Alabiso, O, Alicicco, M, Amadori, D, Amaducci, L, Amiconi, G, Antuzzi, G, Ardine, M, Ardizzoia, A, Aversa, C, Badalamenti, G, Barni, S, Basurto, C, Berardi, R, Bergamasco, C, Bidoli, P, Bighin, C, Biondi, E, Boni, C, Borgonovo, K, Botta, M, Bravi, S, Bruzzi, P, Buono, G, Butera, A, Caldara, A, Candeloro, G, Cappelletti, C, Cardalesi, C, Carfora, E, Cariello, A, Carrozza, F, Carteni, G, Caruso, M, Casadei, V, Casanova, C, Castori, L, Cavanna, L, Cavazzini, G, Cazzaniga, M, Chilelli, M, Chiodini, P, Chiorrini, S, Ciardiello, F, Ciccarese, M, Cinieri, S, Clerico, M, Coccaro, M, Comande, M, Corbo, C, Cortino, G, Cusenza, S, Daniele, G, D'Arco, A, D'Auria, G, Dazzi, C, De Angelis, C, de Braud, F, De Feo, G, De Matteis, A, De Tursi, M, Di Blasio, A, di Lucca, G, Di Lullo, L, Di Rella, F, Di Renzo, G, Di Stefano, P, Di Stefano, A, Diana, A, Donati, S, Fabbri, A, Fabi, A, Faedi, M, Farina, G, Farris, A, Febbraro, A, Fedele, P, Federico, P, Ferrau, F, Ferretti, G, Ferro, A, Floriani, I, Forcignano, R, Forciniti, S, Forestieri, V, Fornari, G, Frisinghelli, M, Fusco, V, Gallizzi, G, Galvano, A, Gambardella, A, Gambi, A, Gebbia, V, Gervasi, E, Ghilardi, M, Giacobino, A, Giardina, G, Giotta, F, Giraudi, S, Giuliano, M, Grassadonia, A, Grasso, D, Grosso, F, Guizzaro, L, Incoronato, P, Incorvaia, L, Iodice, G, La Verde, N, Labonia, V, Landi, G, Latorre, A, Leonardi, V, Levaggi, A, Limite, G, Lina Bascialla, L, Livi, L, Maiello, E, Mandelli, D, Marcon, I, Menon, D, Montedoro, M, Moraca, L, Moretti, A, Morritti, M, Morselli, P, Mura, A, Mura, S, Musacchio, M, Muzio, A, Natale, D, Natoli, C, Nigro, C, Nistico, C, Nuzzo, A, Orditura, M, Orlando, L, Pacilio, C, Palumbo, G, Palumbo, R, Pasini, F, Paterno, E, Pazzola, A, Pelliccioni, S, Pensabene, M, Perroni, D, Pesenti Gritti, A, Petrelli, F, Piccirillo, M, Pinotti, G, Pogliani, C, Poli, D, Prader, S, Recchia, F, Rizzi, D, Romano, C, Rossello, R, Rossini, C, Salvucci, G, Sanna, V, Santini, A, Saracchini, S, Savastano, C, Scambia, G, Schettini, F, Schiavone, P, Schirone, A, Seles, E, Signoriello, S, Signoriello, G, Silva, R, Silvestri, A, Simeon, V, Spagnoletti, I, Tamberi, S, Teragni, C, Thalmann, V, Thomas, R, Thomas, G, Tienghi, A, Tinari, N, Tinessa, V, Tomei, F, Tonini, G, Torri, V, Traficante, D, Tudini, M, Turazza, M, Vignoli, R, Vitale, M, Zacchia, A, Zagarese, P, Zanni, A, Zavallone, L, Zavettieri, M, and Zoboli, A
- Subjects
Oncology ,Receptor, ErbB-2 ,Settore MED/06 - Oncologia Medica ,letrozole ,law.invention ,Adjuvant anastrozole ,chemistry.chemical_compound ,0302 clinical medicine ,Randomized controlled trial ,Exemestane ,law ,exemestane ,tamoxifen ,breast cancer ,Antineoplastic Combined Chemotherapy Protocols ,030212 general & internal medicine ,Aromatase Inhibitors ,Letrozole ,Hazard ratio ,Middle Aged ,Receptors, Estrogen ,Tolerability ,Chemotherapy, Adjuvant ,030220 oncology & carcinogenesis ,Female ,Receptors, Progesterone ,Breast Neoplasm ,Human ,medicine.drug ,medicine.medical_specialty ,Socio-culturale ,Anastrozole ,Breast Neoplasms ,Disease-Free Survival ,Drug Administration Schedule ,03 medical and health sciences ,Breast cancer ,Internal medicine ,medicine ,Aromatase Inhibitor ,Humans ,Aged ,Antineoplastic Combined Chemotherapy Protocol ,Androstadiene ,business.industry ,medicine.disease ,Androstadienes ,chemistry ,business ,Tamoxifen - Abstract
Background: Uncertainty exists about the optimal schedule of adjuvant treatment of breast cancer with aromatase inhibitors and, to our knowledge, no trial has directly compared the three aromatase inhibitors anastrozole, exemestane, and letrozole. We investigated the schedule and type of aromatase inhibitors to be used as adjuvant treatment for hormone receptor-positive early breast cancer. Methods: FATA-GIM3 is a multicentre, open-label, randomised, phase 3 trial of six different treatments in postmenopausal women with hormone receptor-positive early breast cancer. Eligible patients had histologically confirmed invasive hormone receptor-positive breast cancer that had been completely removed by surgery, any pathological tumour size, and axillary nodal status. Key exclusion criteria were hormone replacement therapy, recurrent or metastatic disease, previous treatment with tamoxifen, and another malignancy in the previous 10 years. Patients were randomly assigned in an equal ratio to one of six treatment groups: oral anastrozole (1 mg per day), exemestane (25 mg per day), or letrozole (2·5 mg per day) tablets upfront for 5 years (upfront strategy) or oral tamoxifen (20 mg per day) for 2 years followed by oral administration of one of the three aromatase inhibitors for 3 years (switch strategy). Randomisation was done by a computerised minimisation procedure stratified for oestrogen receptor, progesterone receptor, and HER2 status; previous chemotherapy; and pathological nodal status. Neither the patients nor the physicians were masked to treatment allocation. The primary endpoint was disease-free survival. The minimum cutoff to declare superiority of the upfront strategy over the switch strategy was assumed to be a 2% difference in disease-free survival at 5 years. Primary efficacy analyses were done by intention to treat; safety analyses included all patients for whom at least one safety case report form had been completed. Follow-up is ongoing. This trial is registered with the European Clinical Trials Database, number 2006-004018-42, and ClinicalTrials.gov, number NCT00541086. Findings: Between March 9, 2007, and July 31, 2012, 3697 patients were enrolled into the study. After a median follow-up of 60 months (IQR 46â72), 401 disease-free survival events were reported, including 211 (11%) of 1850 patients allocated to the switch strategy and 190 (10%) of 1847 patients allocated to upfront treatment. 5-year disease-free survival was 88·5% (95% CI 86·7â90·0) with the switch strategy and 89·8% (88·2â91·2) with upfront treatment (hazard ratio 0·89, 95% CI 0·73â1·08; p=0·23). 5-year disease-free survival was 90·0% (95% CI 87·9â91·7) with anastrozole (124 events), 88·0% (85·8â89·9) with exemestane (148 events), and 89·4% (87·3 to 91·1) with letrozole (129 events; p=0·24). No unexpected serious adverse reactions or treatment-related deaths occurred. Musculoskeletal side-effects were the most frequent grade 3â4 events, reported in 130 (7%) of 1761 patients who received the switch strategy and 128 (7%) of 1766 patients who received upfront treatment. Grade 1 musculoskeletal events were more frequent with the upfront schedule than with the switch schedule (924 [52%] of 1766 patients vs 745 [42%] of 1761 patients). All other grade 3â4 adverse events occurred in less than 2% of patients in either group. Interpretation: 5 years of treatment with aromatase inhibitors was not superior to 2 years of tamoxifen followed by 3 years of aromatase inhibitors. None of the three aromatase inhibitors was superior to the others in terms of efficacy. Therefore, patient preference, tolerability, and financial constraints should be considered when deciding the optimal treatment approach in this setting. Funding: Italian Drug Agency.
- Published
- 2018
23. Metabolic and anthropometric changes in early breast cancer patients receiving adjuvant therapy
- Author
-
Anna Crispo, Simona Malgieri, Stefania Cicala, Sabino De Placido, Grazia Arpino, Antonello Accurso, Annamaria Colao, Gennaro Limite, Michelino De Laurentiis, Valeria Forestieri, Giuseppe Buono, Dario Bruzzese, Bianca Maria Veneziani, Rossella Lauria, Carmine De Angelis, Mario Giuliano, Arpino, Grazia, DE ANGELIS, Carmine, Buono, Giuseppe, Colao, Annamaria, Giuliano, Mario, Malgieri, Simona, Cicala, Stefania, DE LAURENTIIS, Michelino, Accurso, Antonello, Crispo, Anna, Limite, Gennaro, Lauria, Rossella, Veneziani, BIANCA MARIA, Forestieri, Valeria, Bruzzese, Dario, and DE PLACIDO, Sabino
- Subjects
Adult ,Blood Glucose ,Cancer Research ,medicine.medical_specialty ,Waist ,Epidemiology ,Breast Neoplasms ,Gastroenterology ,Adjuvant therapy ,Body Mass Index ,chemistry.chemical_compound ,Glucose and lipid metabolism ,Breast cancer ,Waist–hip ratio ,Internal medicine ,Medicine ,Body Fat Distribution ,Humans ,Insulin ,Obesity ,Triglycerides ,medicine.diagnostic_test ,Triglyceride ,business.industry ,Body weight and composition ,Waist-Hip Ratio ,Middle Aged ,medicine.disease ,Lipids ,Postmenopause ,Endocrinology ,Oncology ,chemistry ,Female ,medicine.symptom ,Menopausal status ,Waist Circumference ,business ,Lipid profile ,Body mass index ,Weight gain - Abstract
Weight gain and metabolic changes have been related to survival of early breast cancer patients (EBC). ‘’However, factors influencing metabolism post-diagnosis are not fully understood. We measured anthropometric [body mass index (BMI), body weight, waist and hip circumferences, and waist-to-hip ratio] and metabolic (levels of insulin, glucose, H1Ac, total, HDL, and LDL cholesterol, triglycerides, and the homeostasis model assessment score [HOMA]) parameters in 433 pre- and post-menopausal women with EBC at diagnosis and 3, 6, 9, 12, and 24 months thereafter. At diagnosis, compared with post-menopausal women, pre-menopausal patients were more likely to be leaner and to have a lower BMI, smaller waist and hip circumferences, and waist-to-hip ratio. They had also lower glucose, HbA1c, and triglyceride levels and a lower HOMA score. Furthermore, they were more likely to have an estrogen- and/or progesterone-positive tumor and a higher proliferating breast cancer. During the first two post-diagnosis years, all women showed a significant increase of weight (+0.72 kg/year, P
- Published
- 2015
24. Combined effect of obesity and diabetes on early breast cancer outcome: a prospective observational study
- Author
-
Massimiliano D’Aiuto, L. S. A. Augustin, Rossella Lauria, Carmine De Angelis, Ernesta Cavalcanti, Alfonso Amore, Raffaele Tortoriello, Anna Crispo, Mario Giuliano, Matilde Pensabene, Sabino De Placido, Grazia Arpino, Maurizio Montella, Gerardo Botti, Francesco Schettini, Valeria Forestieri, Antonello Accurso, Giuseppe Buono, Michelino De Laurentiis, Buono, Giuseppe, Crispo, Anna, Giuliano, Mario, de Angelis, Carmine, Schettini, Francesco, Forestieri, Valeria, Lauria, Rossella, Pensabene, Matilde, de Laurentiis, Michelino, Augustin, Livia Silvia Adriana, Amore, Alfonso, D'Aiuto, Massimiliano, Tortoriello, Raffaele, Accurso, Antonello, Cavalcanti, Ernesta, Botti, Gerardo, Montella, Maurizio, de Placido, Sabino, and Arpino, Grazia
- Subjects
0301 basic medicine ,medicine.medical_specialty ,obesity ,Diabete ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,breast cancer ,Diabetes mellitus ,Internal medicine ,Epidemiology ,medicine ,Risk factor ,diabetes ,business.industry ,Hazard ratio ,Cancer ,Combined variable ,medicine.disease ,Obesity ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,outcome ,Population study ,Clinical Research Paper ,business ,combined variables - Abstract
// Giuseppe Buono 1, * , Anna Crispo 2, * , Mario Giuliano 1, 3 , Carmine De Angelis 1 , Francesco Schettini 1 , Valeria Forestieri 1 , Rossella Lauria 1 , Matilde Pensabene 1 , Michelino De Laurentiis 4 , Livia Silvia Adriana Augustin 2, 5 , Alfonso Amore 4 , Massimiliano D’Aiuto 4 , Raffaele Tortoriello 4 , Antonello Accurso 6 , Ernesta Cavalcanti 2 , Gerardo Botti 2 , Maurizio Montella 2 , Sabino De Placido 1 and Grazia Arpino 1 1 Department of Clinical Medicine and Surgery, Oncology Division, University of Naples Federico II, Naples, Italy 2 Unit of Epidemiology, National Cancer Institute, G. Pascale Foundation, Naples, Italy 3 Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA 4 Breast Unit, National Cancer Institute, G. Pascale Foundation, Naples, Italy 5 Clinical Nutrition and Risk Factor Modification Centre, St. Michael’s Hospital, Toronto, Canada 6 Department of Gastroenterology, Endocrinology and Surgery, University of Naples Federico II, Naples, Italy * These authors contributed equally to this work Correspondence to: Grazia Arpino, email: grazia.arpino@unina.it Keywords: breast cancer; obesity; diabetes; combined variables; outcome Received: August 19, 2017 Accepted: November 16, 2017 Published: December 05, 2017 ABSTRACT Background: Previous studies suggested that obesity and diabetes were correlated with breast cancer outcome. The aim of the present study was to investigate the prognostic effect of obesity and diabetes on the outcome of early breast cancer patients. Materials and Methods: Overall, 841 early breast cancer patients were prospectively enrolled between January 2009 and December 2013. Study population was divided into four groups: (1) patients without obesity or diabetes; (2) patients with only diabetes; (3) patients with only obesity; and (4) patients with both diabetes and obesity. Categorical variables were analyzed by the chi-square test and survival data by the log-rank test. Results: At diagnosis, obese and diabetic patients were more likely to be older ( p < 0.0001) and post-menopausal ( p < 0.0001) and to have a tumor larger than 2 cm ( p < 0.0001) than patients in groups 1–3. At univariate analyses, obese and diabetic patients had a worse disease-free survival ( p = 0.01) and overall survival ( p = 0.001) than did patients without obesity and diabetes. At multivariate analyses, the co-presence of obesity and diabetes was an independent prognostic factor for disease-free survival (hazard ratio=2.62, 95% CI 1.23–5.60) but not for overall survival. Conclusions: At diagnosis, patients with obesity and diabetes were older, had larger tumors and a worse outcome compared to patients without obesity or diabetes. These data suggest that metabolic health influences the prognosis of patients affected by early breast cancer.
- Published
- 2017
25. Pretreatment Serum Concentration of Vitamin D and Breast Cancer Characteristics: A Prospective Observational Mediterranean Study
- Author
-
Giuseppe Buono, Rossella Lauria, Carmine De Angelis, Mario Giuliano, Grazia Arpino, Sabino De Placido, Valeria Forestieri, Matilde Pensabene, Dario Bruzzese, Buono, Giuseppe, Giuliano, Mario, DE ANGELIS, Carmine, Lauria, Rossella, Forestieri, Valeria, Pensabene, Matilde, Bruzzese, Dario, DE PLACIDO, Sabino, and Arpino, Grazia
- Subjects
0301 basic medicine ,Adult ,medicine.medical_specialty ,Cancer Research ,Receptor, ErbB-2 ,Estrogen receptor ,Breast Neoplasms ,Gastroenterology ,Body Mass Index ,03 medical and health sciences ,BMI ,0302 clinical medicine ,Breast cancer ,Internal medicine ,Vitamin D and neurology ,medicine ,Humans ,Prospective Studies ,Vitamin D ,Prospective cohort study ,Pathological ,Aggressive feature ,business.industry ,Mediterranean Region ,Middle Aged ,medicine.disease ,Prognosis ,Vitamin D Deficiency ,Obesity ,Primary tumor ,Postmenopause ,030104 developmental biology ,Endocrinology ,Oncology ,Receptors, Estrogen ,030220 oncology & carcinogenesis ,Dietary Supplements ,BC immunohistochemically defined subtype ,Female ,business ,Receptors, Progesterone ,Body mass index ,Follow-Up Studies - Abstract
BACKGROUND: Recent studies of the correlation between breast cancer (BC) and vitamin D yielded contrasting results. Although preclinical and clinical evidence has implicated vitamin D in BC prevention and outcome, little is known about the link between vitamin D and specific BC histologically defined subtypes. In the attempt to clarify this association we correlated vitamin D levels with BC characteristics. PATIENTS AND METHODS: We enrolled 220 pre- and postmenopausal women with early BC in this prospective observational trial. Data on the patients' clinical and specific BC pathological characteristics were collected and related to vitamin D levels, stratified in deficient (< 20 ng/mL), insufficient (20-30 ng/mL), and sufficient (> 30 ng/mL). BC subtypes were defined according to the 14th St Gallen Breast Cancer Conference. RESULTS: Deficient vitamin D levels were correlated with Grade 3 (P = .015) and node-positive (P = .043) BC, and with a higher body mass index (P = .017). Insufficient vitamin D levels were associated with estrogen receptor expression in the primary tumor (P = .033). Vitamin D levels were unrelated to the histological molecular subtypes of BC. CONCLUSION: Deficient vitamin D levels were correlated with more aggressive disease, namely, node-positive high grade BC, and with obesity. Should our findings be confirmed in larger prospective studies, nutritional programs designed to reduce body weight, and vitamin D supplementation might be considered a BC prevention strategy.
- Published
- 2017
26. Long-term survival and BRCA status in male breast cancer: a retrospective single-center analysis
- Author
-
Matilde Pensabene, Grazia Arpino, Rossella Lauria, Valeria Forestieri, Mario Giuliano, Sabino De Placido, Piera Gargiulo, Monica Milano, Caterina Condello, Gargiulo, Piera, Pensabene, Matilde, Milano, Monica, Arpino, Grazia, Giuliano, Mario, Forestieri, Valeria, Condello, Caterina, Lauria, Rossella, and DE PLACIDO, Sabino
- Subjects
Male ,0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,Survival ,Proliferation index ,Receptor, ErbB-2 ,medicine.medical_treatment ,Breast Neoplasms, Male ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Drug Therapy ,Surgical oncology ,Internal medicine ,Genetics ,medicine ,Humans ,skin and connective tissue diseases ,Mastectomy ,Aged ,Retrospective Studies ,BRCA2 Protein ,Radiotherapy ,BRCA1 Protein ,business.industry ,BRCA mutation ,Cancer ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,BRCA mutations ,Male breast cancer ,030104 developmental biology ,030220 oncology & carcinogenesis ,Mutation ,business ,Quadrantectomy ,Research Article - Abstract
Background Male breast cancer (MBC) is rare. Given the paucity of randomized trials, treatment is generally extrapolated from female breast cancer guidelines. Methods This is a retrospective analysis of all male patients presenting with MBC at the Department of Oncology at University Federico II of Naples between January 1989 and January 2014. We recorded the following data: baseline characteristics (age, height, weight, body mass index, risk factors, family history), tumor characteristics (side affected, stage, histotype, hormonal and HER2 status, and Ki-67 expression), treatment (type of surgery, chemotherapy, endocrine therapy, and/or radiotherapy), BRCA1/2 mutation status (if available), other tumors, and long-term survival. Results Forty-seven patients were analyzed. Median age was 62.0 [55.0–72.0]. Among risk factors, obesity and family history of breast cancer were associated with 21 % and 30 % of MBC cases, respectively. The majority of tumors were diagnosed at an early stage: stage I (34.0 %) and stage II (44.7 %). Infiltrating ductal carcinoma was the most frequent histologic subtype (95.8 %). Hormone receptors were generally positive (88.4 % of cases were Estrogen receptor [ER] positive and 81.4 % Progesteron receptor [PgR] positive). Human epidermal growth factor receptor 2 (HER2) was positive in 26.8 % of cases; 7.0 % of MBCs were triple negative. The tumor had high proliferation index (Ki67 ≥ 20 %) in 64.7 %. Surgery was predominantly mastectomy (85.1 %), whereas quadrantectomy was performed in 14.9 % of patients. Adjuvant chemotherapy was administered to 70.7 % of patients, endocrine therapy to 90.2 %, trastuzumab to 16.7 % and radiotherapy to 32.6 %. BRCA status was available for 17 patients: 10 wild-type, 1 BRCA1 carrier, 5 BRCA2 carriers, 1 unknown variant sequence. The overall estimated long-term survival was about 90 % at 5 years, 80 % at 10 years and 70 % at 20 years. Patients carrying a BRCA mutation had a significantly lower survival than patients with wild-type BRCA (p = 0.04). Conclusions Long-term survival was high in MBC patients referred to our clinical unit. Survival was poorer in BRCA-mutated patients than in patients with wild-type BRCA.
- Published
- 2016
- Full Text
- View/download PDF
27. Body weight and risk of molecular breast cancer subtypes among postmenopausal Mediterranean women
- Author
-
Anna Crispo, Giuseppe Buono, Mario Giuliano, Gennaro Ciliberto, Aldo Giudice, Maria Grazia Grimaldi, Grazia Arpino, Massimiliano D’Aiuto, Alfonso Amore, Flavia Nocerino, Valeria Forestieri, Massimo Rinaldo, Emanuela Esposito, Immacolata Capasso, Maurizio Montella, S. De Placido, M. De Laurentiis, M. Di Bonito, Livia S. A. Augustin, Crispo, Anna, Montella, M., Buono, Giuseppe, Grimaldi, M., D'Aiuto, M., Capasso, I., Esposito, E., Amore, A., Nocerino, F., Augustin, L. S. A., Giudice, A., Di Bonito, M., Giuliano, Mario, Forestieri, Valeria, DE LAURENTIIS, Michelino, Rinaldo, M., Ciliberto, G., DE PLACIDO, Sabino, and Arpino, Grazia
- Subjects
0301 basic medicine ,Oncology ,Blood Glucose ,Receptor, ErbB-2 ,Triple Negative Breast Neoplasms ,Body Mass Index ,Breast cancer ,0302 clinical medicine ,Waist–hip ratio ,Medicine ,Insulin ,Progesterone ,Aged, 80 and over ,Medicine (all) ,Incidence (epidemiology) ,Carcinoma, Ductal, Breast ,General Medicine ,Middle Aged ,Postmenopause ,Italy ,Receptors, Estrogen ,030220 oncology & carcinogenesis ,Female ,Disease Susceptibility ,Waist Circumference ,Receptors, Progesterone ,Adult ,medicine.medical_specialty ,Neoplasms, Hormone-Dependent ,Breast Neoplasms ,General Biochemistry, Genetics and Molecular Biology ,Molecular subtype ,BMI ,HOMA-I ,03 medical and health sciences ,Insulin resistance ,Internal medicine ,Biomarkers, Tumor ,Humans ,Risk factor ,Aged ,Retrospective Studies ,Biochemistry, Genetics and Molecular Biology (all) ,business.industry ,Waist-Hip Ratio ,Body Weight ,Estrogens ,Genes, erbB-2 ,medicine.disease ,Obesity ,030104 developmental biology ,Endocrinology ,Insulin Resistance ,business ,Body mass index - Abstract
Breast cancer (BC) is the most common malignant tumor in women, obesity is associated with increased BC incidence and mortality and high levels of circulating insulin may negatively impact on cancer incidence. In the present study, we investigated whether the strength of several anthropometric and metabolic parameters varies between BC molecular subtypes. Eligible cases were 991 non-metastatic BC patients recruited between January 2009 and December 2013. Anthropometric, clinical and immunohistochemical features were measured. Multivariate logistic regression models were built to assess HER2 positive BC risk, comparing (a) triple positive (TP) with luminal A, luminal B and triple negative (TN) and (b) HER2-enriched group with luminal A, luminal B and TN. We stratified patients in pre- and post-menopause: significant differences emerged for luminal A in relation to age: they were more likely to be older compared to other groups. Among postmenopausal patients, the adjusted multivariate analysis showed that high BMI and high waist circumference were inversely correlated to TP subtype when compared to luminal B (OR=0.48 and OR=0.49, respectively). Conversely, HOMA-IR was a risk factor for TP when compared to luminal A and TN (OR=2.47 and OR=3.15, respectively). Our findings suggest a potential role of higher abdominal fat in the development of specific BC molecular subtypes in postmenopausal women. Moreover, they support a potential role of insulin resistance in the development of HER2 positive BC, although this role appears to be stronger when hormone receptors are co-expressed, suggesting a difference in the etiology of these two BC subtypes.
- Published
- 2015
28. Fluorouracil and dose-dense chemotherapy in adjuvant treatment of patients with early-stage breast cancer: an open-label, 2 × 2 factorial, randomised phase 3 trial
- Author
-
Lucia, Del Mastro, Sabino, De Placido, Paolo, Bruzzi, Michele, De Laurentiis, Corrado, Boni, Giovanna, Cavazzini, Antonio, Durando, Anna, Turletti, Cecilia, Nisticò, Enrichetta, Valle, Ornella, Garrone, Fabio, Puglisi, Filippo, Montemurro, Sandro, Barni, Andrea, Ardizzoni, Teresa, Gamucci, Giuseppe, Colantuoni, Mario, Giuliano, Adriano, Gravina, Paola, Papaldo, Claudia, Bighin, Giancarlo, Bisagni, Valeria, Forestieri, Francesco, Cognetti, D, Perrone, Del Mastro, Lucia, DE PLACIDO, Sabino, Bruzzi, Paolo, DE LAURENTIIS, Michelino, Boni, Corrado, Cavazzini, Giovanna, Durando, Antonio, Turletti, Anna, Nisticò, Cecilia, Valle, Enrichetta, Garrone, Ornella, Puglisi, Fabio, Montemurro, Filippo, Barni, Sandro, Ardizzoni, Andrea, Gamucci, Teresa, Colantuoni, Giuseppe, Giuliano, Mario, Gravina, Adriano, Papaldo, Paola, Bighin, Claudia, Bisagni, Giancarlo, Forestieri, Valeria, Cognetti, Francesco, De Placido, Sabino, and De Laurentiis, Michele
- Subjects
Dose-dense chemotherapy ,Kaplan-Meier Estimate ,Gastroenterology ,Interquartile range ,Antineoplastic Combined Chemotherapy Protocols ,Medicine ,Adjuvant ,Mastectomy ,education.field_of_study ,Medicine (all) ,General Medicine ,Middle Aged ,Treatment Outcome ,Fluorouracil ,Chemotherapy, Adjuvant ,Lymphatic Metastasis ,Breast Neoplasm ,Pegfilgrastim ,Human ,medicine.drug ,Epirubicin ,Adult ,medicine.medical_specialty ,Adolescent ,Paclitaxel ,fluorouracil ,dose-dense ,chemotherapy ,Population ,Breast Neoplasms ,Drug Administration Schedule ,Young Adult ,Breast cancer ,Internal medicine ,Chemotherapy ,Humans ,education ,Cyclophosphamide ,Aged ,Neoplasm Staging ,Antineoplastic Combined Chemotherapy Protocol ,business.industry ,Lymphatic Metastasi ,medicine.disease ,Surgery ,Regimen ,Neoplasm Grading ,business - Abstract
Background Whether addition of fluorouracil to epirubicin, cyclophosphamide, and paclitaxel (EC-P) is favourable in adjuvant treatment of patients with node-positive breast cancer is controversial, as is the benefit of increased density of dosing. We aimed to address these questions in terms of improvements in disease-free survival. Methods In this 2 × 2 factorial, open-label, phase 3 trial, we enrolled patients aged 18-70 years with operable, node positive, early-stage breast cancer from 81 Italian centres. Eligible patients were randomly allocated in a 1:1:1:1 ratio with a centralised, interactive online system to receive either dose-dense chemotherapy (administered intravenously every 2 weeks with pegfilgrastim support) with fluorouracil plus EC-P (FEC-P) or EC-P or to receive standard-interval chemotherapy (administered intravenously every 3 weeks) with FEC-P or EC-P. The primary study endpoint was disease-free survival, assessed with the Kaplan-Meier method in the intention-to-treat population. Our primary comparisons were between dose schedule (every 2 weeks vs every 3 weeks) and dose type (FEC-P vs EC-P). This study is registered with ClinicalTrials.gov, number NCT00433420. Findings Between April 24, 2003, and July 3, 2006, we recruited 2091 patients. 88 patients were enrolled in centres that only provided standard-intensity dosing. After a median follow-up of 7·0 years (interquartile range [IQR] 4·5-6·3), 140 (26%) of 545 patients given EC-P every 3 weeks, 157 (29%) of 544 patients given FEC-P every 3 weeks, 111 (22%) of 502 patients given EC-P every 2 weeks, and 113 (23%) of 500 patients given FEC-P every 2 weeks had a disease-free survival event. For the dose-density comparison, disease-free survival at 5 years was 81% (95% CI 79-84) in patients treated every 2 weeks and 76% (74-79) in patients treated every 3 weeks (HR 0·77, 95% CI 0·65-0·92; p=0·004); overall survival rates at 5 years were 94% (93-96) and 89% (87-91; HR 0·65, 0·51-0·84; p=0·001) and for the chemotherapy-type comparison, disease-free survival at 5 years was 78% (75-81) in the FEC-P groups and 79% (76-82) in the EC-P groups (HR 1·06, 0·89-1·25; p=0·561); overall survival rates at 5 years were 91% (89-93) and 92% (90-94; 1·16, 0·91-1·46; p=0·234). Compared with 3 week dosing, chemotherapy every 2 weeks was associated with increased rate of grade 3-4 of anaemia (14 [1·4%] of 988 patients vs two [0·2%] of 984 patients; p=0·002); transaminitis (19 [1·9%] vs four [0·4%]; p=0·001), and myalgias (31 [3·1%] vs 16 [1·6%]; p=0·019), and decreased rates of grade 3-4 neutropenia (147 [14·9%] vs 433 [44·0%]; p
- Published
- 2015
29. Core curriculum. Oncologia clinica
- Author
-
Antonelli, M, Zora, Baretta, Bianco, C, Bianco, R, Bria, E, Cancello, G, Ciardiello, F, Cingarlini, S, Condello, C, Damiano, V, Nullm, nullDe Laurentiis, Nullg, nullDella Vittoria Scarpati, Dieci, Mv, Forestieri, V, Nullg, nullDi Lorenzo, Nullm, nullDi Maio, Guarneri, V, Massari, F, Melisi, D, Morabito, A, Palmieri, G, Pensabene, M, Pepe, S, Perrone, F, Piccirillo, Mc, ARPINO, GRAZIA, CARLOMAGNO, Chiara, BIANCO, ANGELO RAFFAELE, CONTEGIACOMO, ALMA, LAURIA, ROSSELLA, MARINELLI, ALFREDO, MATANO, ELIDE, PERSICO, GIOVANNI, Antonelli M, Arpino G, Zora Baretta, Bianco C, Bianco R, Bria E, Cancello G, Carlomagno C, Bianco AR, Ciardiello F, Cingarlini S, Condello C, Contegiacomo A, Damiano V, De Laurentiis M, Della Vittoria Scarpati G, Dieci MV, Forestieri V, Di Lorenzo G, Di Maio M, Guarneri V, Lauria R, Marinelli A, Massari F, Matano E, Melisi D, Morabito A, Palmieri G, Pensabene M, Pepe S, Perrone F, Persico G, Piccirillo MC, Angelo Raffaele Bianco, Sabino De Placido, Giampaolo Tortora e Pierfranco Conte, Antonelli, M, Arpino, Grazia, Zora, Baretta, Bianco, C, Bianco, Roberto, Bria, E, Cancello, G, Carlomagno, Chiara, Bianco, ANGELO RAFFAELE, Ciardiello, F, Cingarlini, S, Condello, C, Contegiacomo, Alma, Damiano, V, Nullm, nullDe Laurentii, Nullg, nullDella Vittoria Scarpati, Dieci, Mv, Forestieri, Valeria, Nullg, nullDi Lorenzo, Nullm, nullDi Maio, Guarneri, V, Lauria, Rossella, Marinelli, Alfredo, Massari, F, Matano, Elide, Melisi, D, Morabito, A, Palmieri, G, Pensabene, M, Pepe, S, Perrone, F, Persico, Giovanni, Piccirillo, Mc, Lauria E, Bianco, R, and Forestieri, V
- Published
- 2015
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.