41 results on '"Firth, Mike"'
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2. A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo
3. Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing
4. In vivo phage display identifies novel peptides for cardiac targeting
5. Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing
6. Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner
7. Improved nuclease-based prime editing by DNA repair modulation and pegRNA engineering
8. Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner
9. A Novel Screening Approach for the Dissection of Cellular Regulatory Networks of NF-κB Using Arrayed CRISPR gRNA Libraries
10. Delivering Robust Candidates to the Drug Pipeline through Computational Analysis of Arrayed CRISPR Screens
11. Universal toxin-based selection for precise genome engineering in human cells
12. Author Correction: Universal toxin-based selection for precise genome engineering in human cells
13. Rapid target validation in a Cas9-inducible hiPSC derived kidney model
14. High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets
15. CRISPR GUARD protects off-target sites from Cas9 nuclease activity using short guide RNAs
16. In vivo CRISPR editing with no detectable genome-wide off-target mutations
17. BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B
18. Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing
19. 11th German Conference on Chemoinformatics (GCC 2015): Fulda, Germany. 8–10 November 2015
20. Engineered Cas9 extracellular vesicles as a novel gene editing tool
21. Epigenetic modulators link mitochondrial redox homeostasis to cardiac function
22. Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing
23. Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes
24. Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes
25. Universal toxin-based selection for precise genome engineering in human cells
26. Supplemental_Material_GuerrieroEtAl_Computational_Analysis_of_Arrayed_CRISPR_Screens - Delivering Robust Candidates to the Drug Pipeline through Computational Analysis of Arrayed CRISPR Screens
27. R2_Supplemental_Material_for_Arrayed_CRISPRCas_Screen_by_OShea_et_al – Supplemental material for A Novel Screening Approach for the Dissection of Cellular Regulatory Networks of NF-κB Using Arrayed CRISPR gRNA Libraries
28. Additional file 1: of BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B
29. Systematic Evaluation of CRISPRa and CRISPRi Modalities Enables Development of a Multiplexed, Orthogonal Gene Activation and Repression System
30. Understanding Cytotoxicity and Cytostaticity in a High-Throughput Screening Collection
31. In vivo CRISPR-Cas gene editing with no detectable genome-wide off-target mutations
32. Orthologue chemical space and its influence on target prediction
33. Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt’s lymphoma anti-tumor activity
34. Targeted Metabolic Profiling of the Tg197 Mouse Model Reveals Itaconic Acid as a Marker of Rheumatoid Arthritis
35. Understanding Cytotoxicity and Cytostaticity in a High-Throughput Screening Collection
36. Orthologue chemical space and its influence on target prediction.
37. Correction of a urea cycle defect after ex vivogene editing of human hepatocytes
38. Inbox.
39. COME OUT WRITING.
40. AR in Your Car: How HUDs Are Changing Driving: VIRTUAL DISPLAY TECHNOLOGY PROMISES TO GIVE DRIVERS INSTANT INFORMATION, WHILE IMPROVING DRIVER SAFETY.
41. A Novel Screening Approach for the Dissection of Cellular Regulatory Networks of NF-κB Using Arrayed CRISPR gRNA Libraries.
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