57 results on '"Fiorino M"'
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2. Contributors
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Aboseif, Albert, primary, Alessandro, Morandi, additional, Alquézar, Carolina, additional, Anderson, Rachel, additional, Andolf, Ellika, additional, Andreeva, Tatiana, additional, Ano, Yasuhisa, additional, Araki, Yuko, additional, Arroyo-Anlló, Eva M., additional, Ayabe, Tatsuhiro, additional, Bae, Mi Ae, additional, Bakulski, Kelly M., additional, Balcar, Vladimir J., additional, Baldassarro, Vito Antonio, additional, Battista, Petronilla, additional, Bellomo, Antonello, additional, Bednarska-Makaruk, Małgorzata, additional, Benzinger, Tammie L., additional, Berkowitz, Laura E., additional, Berumen, L.C., additional, Bighinati, Andrea, additional, Brodtmann, Amy, additional, Budni, Josiane, additional, Calzà, Laura, additional, Capozzo, Rosa, additional, Caramelli, Paulo, additional, Cardoso, Barbara R., additional, Carr, Jessie S., additional, Carrasco, Javier, additional, Chang, J.W., additional, Chang, Kyung Ja, additional, Chen, Lu Hua, additional, Cheng, Sheung-Tak, additional, Christian, Pozzi, additional, Chu, Leung Wing, additional, Cipriani, G., additional, Clark, Benjamin J., additional, Comes, Gemma, additional, Coppedè, Fabio, additional, Cuadrado-Tejedor, Mar, additional, D'Acunto, Emanuela, additional, Daniele, Antonio, additional, Danti, S., additional, De Jaco, Antonella, additional, de la Torre, Rafael, additional, Di Fiorino, M., additional, Eleonora, Grossi, additional, Endres, Kristina, additional, Escrig, Anna, additional, Farese, Robert V., additional, Fernández-Gayol, Olaya, additional, Fokin, Vitaly, additional, Frenkel, Dan, additional, Fu, Wen, additional, Galliciotti, Giovanna, additional, García-Alcocer, G., additional, Garcia-Osta, Ana, additional, Giardino, Luciana, additional, Gil, Roger, additional, Giralt, Mercedes, additional, Giuseppe, Bellelli, additional, Gomes, Karina Braga, additional, Gonçalves-Pereira, Manuel, additional, González-Gómez, Miriam, additional, Goswami, Nandu, additional, Gottlieb, Elie, additional, Greco, Antonio, additional, Grillo, Dorothy M., additional, Grima, Natalie A., additional, Griseta, Chiara, additional, Guilherme, Malena dos Santos, additional, Harvey, Ryan E., additional, Hashimoto, Manabu, additional, Herrmann, Nathan, additional, Hertzog da Silva Leme, Adriana Gisele, additional, Hibino, Emi, additional, Hidalgo, Juan, additional, Howard, Mark, additional, Hu, Howard, additional, Illarioshkin, Sergey, additional, Inestrosa, Nibaldo C., additional, Jhamandas, Jack H., additional, Khan, Amber, additional, La Montagna, Maddalena, additional, Lanctôt, Krista L., additional, Laskowska-Kaszub, Katarzyna, additional, Lee, Han-Kyu, additional, Liu, Lei, additional, Liu, Celina S., additional, Llorente-Ovejero, Alberto, additional, Logroscino, Giancarlo, additional, Lombardero, Laura, additional, Lozano, Stephanie, additional, Lozupone, Madia, additional, Manso, Yasmina, additional, Manuel, Iván, additional, Marin, Raquel, additional, Martín-Requero, Ángeles, additional, Martino Adami, Pamela V., additional, Mendiola-Precoma, J., additional, Miranda, Elena, additional, Mitsuishi, Yachiyo, additional, Molinero, Amalia, additional, Morelli, Laura, additional, Morris, John C., additional, Murphy, Kelsey E., additional, Nakano, Masaki, additional, Nagaraj, Siranjeevi, additional, Nash, Yuval, additional, Nishimura, Masaki, additional, Nuti, A., additional, de Oliveira, Jade, additional, Panza, Francesco, additional, Park, Joshua J., additional, Park, Y.S., additional, Park, Sung Kyun, additional, Pase, Matthew P., additional, Picchi, L., additional, Ponomareva, Natalya, additional, Poole, Matthew L., additional, Preedy, Victor R., additional, Puertas-Avendaño, Ricardo, additional, Querfurth, Henry, additional, Quinto-Alemany, David, additional, Ravic de Miranda, Luís Felipe José, additional, Rajendram, Rajkumar, additional, Resta, Onofrio, additional, Reinhardt, Sven, additional, Rodríguez-Cruz, A., additional, Rodríguez-Puertas, Rafael, additional, Rogaev, Evgeny, additional, Rosen, Michael, additional, Sajan, Mini P., additional, Sanchis, Paula, additional, Sannia, Michele, additional, Sardone, Rodolfo, additional, Sasaki, Makoto, additional, Sepulveda-Falla, Diego, additional, Seripa, Davide, additional, Šerý, Omar, additional, Sirkis, Daniel W., additional, Song, You-Qiang, additional, Su, Brenda Bin, additional, Sugi, Takuma, additional, Villaseca, Paulina, additional, Vogel, Adam P., additional, Walker, Douglas Gordon, additional, Wang, Hoau-Yan, additional, Wang, Kesheng, additional, Watanabe, Naoki, additional, Weidman, David, additional, Wojda, Urszula, additional, Woo, Benjamin K.P., additional, Xicota, Laura, additional, Xu, Chun, additional, Yablonskiy, Dmitriy A., additional, Yamashita, Fumio, additional, Yao, Hiroshi, additional, Yokoyama, Jennifer S., additional, Zhang, Fan, additional, Zolezzi, Juan M., additional, and Zoltowska, Katarzyn Marta, additional
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- 2020
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3. Disordered gambling and dementia
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Cipriani, G., Cammisuli, D.M., Danti, S., and Di Fiorino, M.
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- 2016
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4. Utility of a buccal swab point-of-care test for the IFNL4 genotype in the era of direct acting antivirals for hepatitis C virus
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Sy, A, McCabe, L, Hudson, E, Ansari, AM, Pedergnana, V, Lin, S-K, Santana, S, Fiorino, M, Ala, A, Stone, B, Smith, M, Nelson, M, Barclay, ST, McPherson, S, Ryder, SD, Collier, J, Barnes, E, Walker, AS, Pett, SL, Cooke, G, STOP-HCV-1 trial team, and team, STOP-HCV-1 trial
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Multidisciplinary - Abstract
Background The CC genotype of the IFNL4 gene is known to be associated with increased Hepatitis C (HCV) cure rates with interferon-based therapy and may contribute to cure with direct acting antivirals. The Genedrive® IFNL4 is a CE marked Point of Care (PoC) molecular diagnostic test, designed for in vitro diagnostic use to provide rapid, real-time detection of IFNL4 genotype status for SNP rs12979860. Methods 120 Participants were consented to a substudy comparing IFNL4 genotyping results from a buccal swab analysed on the Genedrive® platform with results generated using the Affymetix UK Biobank array considered to be the gold standard. Results Buccal swabs were taken from 120 participants for PoC IFNL4 testing and a whole blood sample for genetic sequencing. Whole blood genotyping vs. buccal swab PoC testing identified 40 (33%), 65 (54%), and 15 (13%) had CC, CT and TT IFNL4 genotype respectively. The Buccal swab PoC identified 38 (32%) CC, 64 (53%) CT and 18 (15%) TT IFNL4 genotype respectively. The sensitivity and specificity of the buccal swab test to detect CC vs non-CC was 90% (95% CI 76–97%) and 98% (95% CI 91–100%) respectively. Conclusions The buccal swab test was better at correctly identifying non-CC genotypes than CC genotypes. The high specificity of the Genedrive® assay prevents CT/TT genotypes being mistaken for CC, and could avoid patients being identified as potentially ‘good responders’ to interferon-based therapy.
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- 2023
5. Correction to: Mesoglycan for pain control after open excisional HAEMOrrhoidectomy (MeHAEMO): an observational multicentre study on behalf of the Italian Society of Colorectal Surgery (SICCR) (BMC Surgery, (2020), 20, 1, (251), 10.1186/s12893-020-00914-5)
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Gallo G., Di Saverio S., Clerico G., Sturiale A., Manigrasso M., Luc A. R., Trompetto M., Sammarco G., Ferrari F., Carpino A., Sena G., Vescio G., Stratta E., Tonello P., Cornaglia S., Greco V., Talarico C., Tutino R., Falco N., Venturelli P., Cocorullo G., Pietroletti R., Rizza V., Milito G., Campanelli M., Lisi G., Brachitta S., Cavallaro V., Pecorella G., Turri B., Sasia D., Giuffrida M. C., Milone M., Palma G. D., Bianco V., Moggia E., Talamo G., Oggianu A., Pili M., Palumbo A., Fazio M., Aiello D., Bianco F., Bondurri A., La Torre M., Mancini S., Perinotti R., Serventi A., Fiorino M., Gallo G., Di Saverio S., Clerico G., Sturiale A., Manigrasso M., Luc A.R., Trompetto M., Sammarco G., Ferrari F., Carpino A., Sena G., Vescio G., Stratta E., Tonello P., Cornaglia S., Greco V., Talarico C., Tutino R., Falco N., Venturelli P., Cocorullo G., Pietroletti R., Rizza V., Milito G., Campanelli M., Lisi G., Brachitta S., Cavallaro V., Pecorella G., Turri B., Sasia D., Giuffrida M.C., Milone M., Palma G.D., Bianco V., Moggia E., Talamo G., Oggianu A., Pili M., Palumbo A., Fazio M., Aiello D., Bianco F., Bondurri A., La Torre M., Mancini S., Perinotti R., Serventi A., Fiorino M., Gallo, G., Di Saverio, S., Clerico, G., Sturiale, A., Manigrasso, M., Luc, A. R., Trompetto, M., Sammarco, G., Ferrari, F., Carpino, A., Sena, G., Vescio, G., Stratta, E., Tonello, P., Cornaglia, S., Greco, V., Talarico, C., Tutino, R., Falco, N., Venturelli, P., Cocorullo, G., Pietroletti, R., Rizza, V., Milito, G., Campanelli, M., Lisi, G., Brachitta, S., Cavallaro, V., Pecorella, G., Turri, B., Sasia, D., Giuffrida, M. C., Milone, M., Palma, G. D., Bianco, V., Moggia, E., Talamo, G., Oggianu, A., Pili, M., Palumbo, A., Fazio, M., Aiello, D., Bianco, F., Bondurri, A., La Torre, M., Mancini, S., Perinotti, R., Serventi, A., and Fiorino, M.
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Emtree - Abstract
An amendment to this paper has been published and can be accessed via the original article.
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- 2020
6. Mesoglycan for pain control after open excisional HAEMOrrhoidectomy (MeHAEMO): an observational multicentre study on behalf of the Italian Society of Colorectal Surgery (SICCR)
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Gallo, G., Di Saverio, S., Clerico, G., Sturiale, A., Manigrasso, M., Luc, A. R., Trompetto, M., Sammarco, G., Ferrari, F., Carpino, A., Sena, G., Vescio, G., Stratta, E., Tonello, P., Cornaglia, S., Greco, V., Talarico, C., Tutino, R., Falco, N., Venturelli, P., Cocorullo, G., Pietroletti, R., Rizza, V., Milito, G., Campanelli, M., Lisi, G., Brachitta, S., Cavallaro, V., Pecorella, G., Turri, B., Sasia, D., Giuffrida, M. C., Milone, M., Palma, G., Bianco, V., Moggia, E., Talamo, G., Oggianu, A., Pili, M., Palumbo, A., Fazio, M., Aiello, D., Bianco, F., Bondurri, A., Torre, M., Macini, S., Perinotti, R., Serventi, A., Fiorino, M., Gallo, G., Di Saverio, S., Clerico, G., Sturiale, A., Manigrasso, M., Luc, A. R., Trompetto, M., Sammarco, G., Ferrari, F., Carpino, A., Sena, G., Vescio, G., Stratta, E., Tonello, P., Cornaglia, S., Greco, V., Talarico, C., Tutino, R., Falco, N., Venturelli, P., Cocorullo, G., Pietroletti, R., Rizza, V., Milito, G., Campanelli, M., Lisi, G., Brachitta, S., Cavallaro, V., Pecorella, G., Turri, B., Sasia, D., Giuffrida, M. C., Milone, M., Palma, G., Bianco, V., Moggia, E., Talamo, G., Oggianu, A., Pili, M., Palumbo, A., Fazio, M., Aiello, D., Bianco, F., Bondurri, A., Torre, M., Macini, S., Perinotti, R., Serventi, A., and Fiorino, M.
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Male ,medicine.medical_treatment ,haemorrhoidal disease ,post-operative pain ,open excisional haemorrhoidectomy ,mesoglycan ,thrombosis ,mucocutaneous bridges ,Open excisional haemorrhoidectomy ,Haemorrhoidal disease ,Mesoglycan ,Mucocutaneous bridges ,Post-operative pain ,Thrombosis ,Mucocutaneous bridge ,Retrospective Studie ,80 and over ,Glycosaminoglycans ,Aged, 80 and over ,Pain, Postoperative ,Fibrinolytic Agent ,General Medicine ,Middle Aged ,Colorectal surgery ,Treatment Outcome ,Thrombosi ,Female ,Human ,Research Article ,Adult ,Hemorrhoidectomy ,medicine.medical_specialty ,lcsh:Surgery ,Pain ,Hemorrhoids ,Young Adult ,Pain control ,Fibrinolytic Agents ,medicine ,Humans ,Postoperative ,Aged ,Retrospective Studies ,business.industry ,Gold standard ,Correction ,Diathermy ,lcsh:RD1-811 ,medicine.disease ,Surgery ,Glycosaminoglycan ,Defecation ,Observational study ,business ,Hemorrhoid - Abstract
Background Excisional haemorrhoidectomy is the gold standard technique in patients with III and IV degree haemorrhoidal disease (HD). However, it is associated with a significant rate of post-operative pain. The aim of our study was to evaluate the efficacy of mesoglycan in the post-operative period of patients who underwent open excisional diathermy haemorrhoidectomy (OEH). Methods This was a retrospective multicentre observational study. Three hundred ninety-eight patients from sixteen colorectal referral centres who underwent OEH for III and IV HD were enrolled. All patients were followed-up on the first post-operative day (T1) and after 1 week (T2), 3 weeks (T3) and 6 weeks (T4). BMI, habits, SF-12 questionnaire, VAS at rest (VASs), after defecation (VASd), and after anorectal digital examination (VASe), bleeding and thrombosis, time to surgical wound healing and autonomy were evaluated. Results In the mesoglycan group, post-operative thrombosis was significantly reduced at T2 (p Conclusions The use of mesoglycan led to a significant reduction in post-operative thrombosis and pain with consequent early resumption of autonomy. Trial registration NCT04481698—Mesoglycan for Pain Control After Open Excisional HAEMOrrhoidectomy (MeHAEMO) https://clinicaltrials.gov/ct2/show/NCT04481698?term=Mesoglycan+for+Pain+Control+After+Open+Excisional+HAEMOrrhoidectomy+%28MeHAEMO%29&draw=2&rank=1
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- 2020
7. Quality control of B-lines analysis in stress Echo 2020
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Scali, M. C., Ciampi, Q., Picano, E., Bossone, E., Ferrara, F., Citro, R., Colonna, P., Costantino, M. F., Cortigiani, L., Andrea, A. D., Severino, S., Dodi, C., Gaibazzi, N., Galderisi, M., Barbieri, A., Monte, I., Mori, F., Reisenhofer, B., Re, F., Rigo, F., Trambaiolo, P., Amor, M., Lowenstein, J., Merlo, P. M., Daros, C. B., De Castro E Silva Pretto, J. L., Miglioranza, M. H., Torres, M. A. R., De Azevedo Bellagamba, C. C., Chaves, D. Q., Simova, I., Varga, A., Celutkiene, J., Kasprzak, J. D., Wierzbowska-Drabik, K., Lipiec, P., Weiner-Mik, P., Szymczyk, E., Wdowiak-Okrojek, K., Djordjevic-Dikic, A., Dekleva, M., Stankovic, I., Neskovic, A. N., Zagatina, A., Di Salvo, G., Perez, J. E., Camarozano, A. C., Corciu, A. I., Boshchenko, A., Lattanzi, F., Cotrim, C., Fazendas, P., Haberka, M., Sobkowic, B., Kosmala, W., Witkowski, T., Gosciniak, P., Salustri, A., Rodriguez-Zanella, H., Leal, L. I. M., Nikolic, A., Gligorova, S., Urluescu, M. -L., Fiorino, M., Novo, G., Preradovic-Kovacevic, T., Ostojic, M., Beleslin, B., Villari, B., De Nes, M., Paterni, M., Carpeggiani, C., Andreassi, M. G., Scali, Maria Chiara, Ciampi, Quirino, Picano, Eugenio, Bossone, Eduardo, Ferrara, Francesco, Citro, Rodolfo, Colonna, Paolo, Costantino, Marco Fabio, Cortigiani, Lauro, Andrea, Antonello D'., Severino, Sergio, Dodi, Claudio, Gaibazzi, Nicola, Galderisi, Maurizio, Barbieri, Andrea, Monte, Ine, Mori, Fabio, Reisenhofer, Barbara, Re, Federica, Rigo, Fausto, Trambaiolo, Paolo, Amor, Miguel, Lowenstein, Jorge, Merlo, Pablo Martin, Daros, Clarissa Borguezan, De Castro E Silva Pretto, José Lui, Miglioranza, Marcelo Haertel, Torres, Marco A. R., De Azevedo Bellagamba, Clarissa Carmona, Chaves, Daniel Quesada, Simova, Iana, Varga, Albert, Čelutkiene, Jelena, Kasprzak, Jaroslaw D., Wierzbowska-Drabik, Karina, Lipiec, Piotr, Weiner-Mik, Paulina, Szymczyk, Eva, Wdowiak-Okrojek, Katarzyna, Djordjevic-Dikic, Ana, Dekleva, Milica, Stankovic, Ivan, Neskovic, Aleksandar N., Zagatina, Angela, Di Salvo, Giovanni, Perez, Julio E., Camarozano, Ana Cristina, Corciu, Anca Irina, Boshchenko, Alla, Lattanzi, Fabio, Cotrim, Carlo, Fazendas, Paula, Haberka, Maciej, Sobkowic, Bozena, Kosmala, Wojciech, Witkowski, Tomasz, Gosciniak, Piotr, Salustri, Alessandro, Rodriguez-Zanella, Hugo, Leal, Luis Ignacio Martin, Nikolic, Alexandra, Gligorova, Suzana, Urluescu, Madalina-Loredana, Fiorino, Maria, Novo, Giuseppina, Preradovic-Kovacevic, Tamara, Ostojic, Miodrag, Beleslin, Branko, Villari, Bruno, De Nes, Michele, Paterni, Marco, Carpeggiani, Clara, Andreassi, Maria Grazia, Scali, Mc, Ciampi, Q, Picano, E, Bossone, E, Ferrara, F, Citro, R, Colonna, P, Costantino, Mf, Cortigiani, L, D'Andrea, A, Severino, S, Dodi, C, Gaibazzi, N, Galderisi, M, Barbieri, A, Monte, I, Mori, F, Reisenhofer, B, Re, F, Rigo, F, Trambaiolo, P, Amor, M, Lowenstein, J, Merlo, Pm, Daros, Cb, Pretto, Jlde, Miglioranza, Mh, Torres, Mar, Bellagamba, Ccd, Chaves, Dq, Simova, I, Varga, A, Celutkiene, J, Kasprzak, Jd, Wierzbowska-Drabik, K, Lipiec, P, Weiner-Mik, P, Szymczyk, E, Wdowiak-Okrojek, K, Djordjevic-Dikic, A, Dekleva, M, Stankovic, I, Neskovic, An, Zagatina, A, Di Salvo, G, Perez, Je, Camarozano, Ac, Corciu, Ai, Boshchenko, A, Lattanzi, F, Cotrim, C, Fazendas, P, Haberka, M, Sobkowic, B, Kosmala, W, Witkowski, T, Gosciniak, P, Salustri, A, Rodriguez-Zanella, H, Leal, Lim, Nikolic, A, Gligorova, S, Urluescu, Ml, Fiorino, M, Novo, G, Preradovic-Kovacevic, T, Ostojic, M, Beleslin, B, Villari, B, De Nes, M, Paterni, M, and Carpeggiani, C
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Male ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Diagnostic accuracy ,030204 cardiovascular system & hematology ,0302 clinical medicine ,Nuclear Medicine and Imaging ,Reading (process) ,Medicine ,Lung ,media_common ,Controle de qualidade ,certification ,lung comets ,quality control ,stress echocardiography ,wall motion ,General Medicine ,Middle Aged ,Echocardiography ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,Human ,Echocardiography, Stress ,Quality Control ,Certification ,Lung comets ,Quality control ,Stress echocardiography ,Wall motion ,Humans ,Internet ,Pulmonary Edema ,Radiology, Nuclear Medicine and Imaging ,medicine.medical_specialty ,Correlation coefficient ,media_common.quotation_subject ,Stress ,Lung comet ,Ecocardiografia sob estresse ,03 medical and health sciences ,Echocardiography, Stre ,Internal medicine ,Radiology, Nuclear Medicine and imaging ,Quality (business) ,Doenças cardiovasculares ,business.industry ,030208 emergency & critical care medicine ,Gold standard (test) ,Lung ultrasound ,lcsh:RC666-701 ,Stress Echo ,Nuclear medicine ,business ,Certificação - Abstract
Background The effectiveness trial “Stress echo (SE) 2020” evaluates novel applications of SE in and beyond coronary artery disease. The core protocol also includes 4-site simplified scan of B-lines by lung ultrasound, useful to assess pulmonary congestion. Purpose To provide web-based upstream quality control and harmonization of B-lines reading criteria. Methods 60 readers (all previously accredited for regional wall motion, 53 B-lines naive) from 52 centers of 16 countries of SE 2020 network read a set of 20 lung ultrasound video-clips selected by the Pisa lab serving as reference standard, after taking an obligatory web-based learning 2-h module ( http://se2020.altervista.org ). Each test clip was scored for B-lines from 0 (black lung, A-lines, no B-lines) to 10 (white lung, coalescing B-lines). The diagnostic gold standard was the concordant assessment of two experienced readers of the Pisa lab. The answer of the reader was considered correct if concordant with reference standard reading ±1 (for instance, reference standard reading of 5 B-lines; correct answer 4, 5, or 6). The a priori determined pass threshold was 18/20 (≥ 90%) with R value (intra-class correlation coefficient) between reference standard and recruiting center) > 0.90. Inter-observer agreement was assessed with intra-class correlation coefficient statistics. Results All 60 readers were successfully accredited: 26 (43%) on first, 24 (40%) on second, and 10 (17%) on third attempt. The average diagnostic accuracy of the 60 accredited readers was 95%, with R value of 0.95 compared to reference standard reading. The 53 B-lines naive scored similarly to the 7 B-lines expert on first attempt (90 versus 95%, p = NS). Compared to the step-1 of quality control for regional wall motion abnormalities, the mean reading time per attempt was shorter (17 ± 3 vs 29 ± 12 min, p
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- 2018
8. Attitude toward prescription and clinical monitoring of lithium salts in a sample of Italian psychiatrists: preliminary data
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Pacciardi, B, Palagini, L, Mainardi, C, Cotugno, B, Cargioli, C, Perugi, G, and Di Fiorino, M
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Psychiatry ,Psychopharmacology ,Mood stabilizers ,Psychiatry, Psychopharmacology, Mood stabilizers, Lithium, Survey, Clinical practice ,Lithium ,Clinical practice ,Survey ,NO - Published
- 2017
9. OC-025 Roc-king onwards: iel counts, distributions, & roles in mucosal interpretation
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Rostami, K, primary, Marsh, MN, additional, Johnson, MW, additional, Srivastava, A, additional, Ensari, A, additional, Holmes, G, additional, Mohaghegh, H, additional, Neefjes-Borst, A, additional, Bozzola, A, additional, Mathews, S, additional, Mulder, CJ, additional, Mandolesi, A, additional, Ferrero, S, additional, Bancel, B, additional, Volta, U, additional, Rostami-Nejad, M, additional, Ali, JI, additional, Ciacci, C, additional, Sotoudeh, M, additional, Goldin, R, additional, Ganji, A, additional, Robert, M, additional, Bassoti, G, additional, Ghafarzadehgan, K, additional, Carroccio, A, additional, Villanacci, V, additional, Catassi, C, additional, Ciobanu, A, additional, Aldulaimi, D, additional, Fiorentino, M, additional, Derakhshan, M, additional, Becheanu, G, additional, Bateman, A, additional, Zali, MR, additional, Russo, I, additional, Fiorino, M, additional, Maxim, R, additional, Danciu, M, additional, Ishaq, S, additional, Elli, L, additional, Going, J, additional, and Heal, C, additional
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- 2017
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10. Anophthalmic Socket Syndrome: Prevalence, Impact and Management Strategies
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Quaranta-Leoni FM, Fiorino MG, Quaranta-Leoni F, and Di Marino M
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orbital implants ,socket surgery ,contracted socket ,phantom eye syndrome ,congenital anophthalmia ,Ophthalmology ,RE1-994 - Abstract
Francesco M Quaranta-Leoni,1,2 Maria Grazia Fiorino,1 Flavia Quaranta-Leoni,3 Matteo Di Marino1 1Orbital and Adnexal Service, Villa Tiberia Hospital – GVM Care & Research, Rome, 00137, Italy; 2Oftalmoplastica Roma, Rome, 00197, Italy; 3Catholic University of the Sacred Heart, Rome, 00168, ItalyCorrespondence: Francesco M Quaranta-Leoni Email fquarantaleoni@gmail.comAbstract: Anophthalmic socket syndrome determines functional deficits and facial deformities, and may lead to poor psychological outcomes. This review aims to comprehensively evaluate the features of the syndrome, based on literature review and authors’ clinical and surgical experience. An electronic database (PubMed,MEDLINE and Google Scholar) search of all articles written in English and non-English language with abstract translated to English on anophthalmic socket syndrome was performed. Data reviewed included demographics, presentations, investigations, management, complications and outcomes. Different types of orbital implants were evaluated; the management of implant exposure was examined; different orbital volume enhancement procedures such as secondary implantation, subperiosteal implants and the use of fillers in anophthalmic patients were described; the problems related to socket contraction were outlined; the treatment options for chronic anophthalmic socket pain and phantom eye syndrome were assessed; the most recent advances in the management of congenital anophthalmia were described. Current clinical evidence does not support a specific orbital implant; late exposure of porous implants may be due to pegging, which currently is seldom used; filler absorption in the orbit appears to be faster than in the dermis, and repeated treatments could be a potential source of inflammation; socket contraction results in significant functional and psychological disability, and management is challenging. Patients affected by anophthalmic socket pain and phantom eye syndrome need specific counseling. It is auspicable to use a standardized protocol to treat children affected by clinical congenital anophthalmia; dermis fat graft is a suitable option in these patients as it helps continued socket expansion. Dermis fat graft can also address the volume deficit in case of explantation of exposed implants and in contracted sockets in both children and adults. Appropriate clinical care is essential, as adequate prosthesis wearing improves the quality of life of anophthalmic patients.Keywords: orbital implants, socket surgery, contracted socket, phantom eye syndrome, congenital anophthalmia
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- 2021
11. Prevalence of Maternal Postnatal Anxiety and Its Association With Demographic and Socioeconomic Factors: A Multicentre Study in Italy
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Loredana Cena, Antonella Gigantesco, Fiorino Mirabella, Gabriella Palumbo, Alice Trainini, and Alberto Stefana
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postnatal anxiety ,obstetric factors ,socioeconomic factors ,demographic factors ,psychological support ,Psychiatry ,RC435-571 - Abstract
Anxiety is a common perinatal disorder that can cause severe adverse consequences. This study (a) assesses the prevalence of maternal postnatal anxious symptomatology, and (b) analyses its association with demographic and socioeconomic variables as well as obstetric and other psychosocial variables. The assessment included 307 mothers aged ≥18 years with a biological baby aged ≤ 52 weeks and from seven Italian healthcare centres, evaluated using a Psychosocial and Clinical Assessment Form (also covering demographic and socioeconomic factors), and the state scale of the State-Trait Anxiety Inventory. We found an overall prevalence of self-reported postnatal anxious symptoms of 34.2%. More specifically, the prevalence was 34.5% at 1–24 weeks postpartum, and 30.8% at >24 weeks postpartum. No associations between postnatal anxious symptoms and demographic or socioeconomic variables were observed. As regards the other variables, the findings indicated antenatal depression or anxiety, parity, and current psychological support from the partner as having the strongest relationships.
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- 2021
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12. The limited screening accuracy of the Patient Health Questionnaire-2 in detecting depression among perinatal women in Italy.
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Antonella Gigantesco, Gabriella Palumbo, Loredana Cena, Laura Camoni, Alice Trainini, Alberto Stefana, and Fiorino Mirabella
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Medicine ,Science - Abstract
BackgroundThe PHQ-2 was recently recommended by the International Consortium for Health Outcomes Measurement as a form of initial perinatal screening, followed by the EPDS only for women with positive PHQ-2 score. However, the accuracy of the PHQ-2 in perinatal clinical practice has been barely researched, to date. In the present study, we aim to assess the accuracy of the PHQ-2 against the EPDS in a large sample of perinatal women.MethodsA total of 1155 consecutive women attending eleven primary or secondary health care centres throughout Italy completed the EPDS and the PHQ-2 during pregnancy (27-40-weeks) or postpartum (1-13-weeks). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio, negative likelihood ratio, post-test probabilities and area under the curve (AUC) of the PHQ-2, using a cut-off of ≥ 3, were calculated.Main findingsDuring pregnancy, PHQ-2 revealed low sensitivity (39.5%) and PPV (39.4%) but high specificity and NPV (97.5%). In postpartum, it revealed very low sensitivity (32.7%) and moderately high NPV (80.9%), but high specificity (99.3%) and PPV (94.4%). Given the low sensitivity despite the high specificity, the PHQ-2 demonstrated poor accuracy (AUC from 0.66 to 0.68).ConclusionInitial screening by means of PHQ-2 failed to identify an acceptable number of perinatal women at-risk of depression in Italian clinical practice. The PHQ-2 performance suggested that it has insufficient sensitivity and discriminatory power, and may be inadequate as a screening tool for maternal depression.
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- 2021
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13. Perspectives on Early Screening and Prompt Intervention to Identify and Treat Maternal Perinatal Mental Health. Protocol for a Prospective Multicenter Study in Italy
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Loredana Cena, Gabriella Palumbo, Fiorino Mirabella, Antonella Gigantesco, Alberto Stefana, Alice Trainini, Nella Tralli, and Antonio Imbasciati
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perinatal ,antenatal ,postnatal ,anxiety ,depression ,screening ,Psychology ,BF1-990 - Abstract
BackgroundThe most common mental disorders in women during the perinatal (antenatal and postnatal) period are depressive syndromes and anxiety syndromes. The global prevalence of maternal perinatal depression ranges from 10 to 20%, while the prevalence of perinatal anxiety ranges from 10 to 24%. The comorbidity of mood and anxiety disorders in perinatal women is common, reaching 40%. In Italy, a few studies have been undertaken to evaluate the prevalence of perinatal depression and anxiety, and there is still a scarcity of research and intervention programs regarding primary prevention. Three of the main aims of this study are: (1) to evaluate the prevalence of maternal perinatal depression and anxiety in a large sample of women attending healthcare centers in Italy; (2) to investigate the psychosocial risks and protective factors associated with maternal perinatal depression and anxiety; (3) to evaluate the effectiveness of a manualized psychological intervention (Milgrom et al., 1999) to treat perinatal depression; (4) to evaluate the psychometric properties of both the Edinburgh Postnatal Depression Scale and the Patient Health Questionnaire-9 in detecting perinatal depression; and (5) to evaluate the influence of maternal depression and anxiety on the development of infant temperament.MethodsThis is a prospective cohort study, which merges an observational design and a pre-post intervention design. The study includes a 1-year recruitment period and a one-year follow-up period. The methodological strategy includes: (1) self-report questionnaires on maternal depression, anxiety, health status, quality of life and psychosocial risks; (2) a self-report questionnaire to measure the infant’s temperament; (3) a clinical interview; (4) a structured diagnostic interview; and (5) a psychological intervention.DiscussionThe results of this study may contribute to our knowledge about prevalence of antenatal and postnatal depression and anxiety (during both the trimesters of pregnancy and the first six trimesters after birth) and about the effectiveness of early psychological intervention in the perinatal health services.
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- 2020
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14. Cross-cultural adaptation and validation of the Italian version of the Hip disability and Osteoarthritis Outcome Score (HOOS)
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Marina Torre, Ilaria Luzi, Fiorino Mirabella, Martina Del Manso, Gustavo Zanoli, Gabriele Tucci, and Emilio Romanini
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HOOS ,Hip osteoarthritis ,Total hip arthroplasty ,Cross-cultural validation ,Registry ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Objective To create a translated version of the HOOS to fit the Italian population and to test its psychometric properties and validity in hip osteoarthritis (OA) patients undergoing total hip arthroplasty (THA). Design The HOOS Italian version was developed according to published international guidelines that include preparation, forward translation and reconciliation, backward translation, review and harmonization, and proof reading. The Italian HOOS was administered to 145 patients (mean age 65.7 ± 11.6 years, 34–89, 58.6% women) undergoing THA. The following psychometric properties were evaluated: internal consistency (Cronbach’s alpha); test-retest reliability (Pearson’s r and intra-class correlation coefficient, ICC); convergent validity (Spearman’s rho between HOOS and SF-36); responsiveness (comparison of pre/post-THA scores, Wilcoxon signed rank test). Interpretability (floor and ceiling effects, skewness and kurtosis indexes) and acceptability (time to compiling, missing answers, and autonomy in compilation) were also evaluated. Results Translation and transcultural adaptation were conducted in accordance with the international recommendation. The translation was deemed understandable and appropriate as to the transcultural adaptation. None of the patients reported to have met any difficulties in reading and understanding the HOOS items. Internal consistency and test-retest reliability were good for each HOOS subscale (Cronbach’s alpha ≥0.7, Pearson’s r and ICC > 0.80). Convergent validity showed the highest correlations (Spearman’s rho > 0.5) between HOOS and SF-36 subscales relating to similar dimensions. As to responsiveness, all HOOS subscales scores improved significantly after THA (p
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- 2018
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15. PSYChosomatic Medicine in ONcologIc and Cardiac Disease (PSYCHONIC) Study—A Retrospective and Prospective Observational Research Protocol
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Adriana Roncella, Christian Pristipino, Oretta Di Carlo, Matteo Ansuini, Angela Corbosiero, Stefania Angela Di Fusco, Gabriella Palumbo, Antonella Gigantesco, Fiorino Mirabella, Rosanna De Angelis, Vincenzo Pasceri, Laura Cancellara, Furio Colivicchi, Robert Allan, Maria Alessandra Mirri, and Giulio Speciale
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ontopsychology ,psychotherapy ,dreams ,acute myocardial infarction ,takotsubo syndrome ,breast cancer ,Medicine - Abstract
Psychosocial factors play an important role in non-communicable diseases (NCDs). This observational study is primarily aimed at assessing the relationship of psychological characteristics of patients with the outcomes of different NCDs, and to assess short-term psychotherapy (STP) efficacy in the real world. Methods: One hundred and forty patients with recent acute myocardial infarction, Takotsubo syndrome, or non-metastatic breast cancer and a control group of 140 age and sex-matched healthy subjects, will be enrolled. All subjects will be administered psychometric tests, quality of life tests, a specific body perception questionnaire, a dream questionnaire, and a projective test, the Six Drawing test at baseline and follow-up. All subjects with medical conditions will be asked to freely choose between an ontopsychological STP along with standard medical therapy and, whenever indicated, rehabilitation therapy or medical therapy plus rehabilitation alone. The study endpoints will be to evaluate: the relationship of the psychological characteristics of enrolled subjects with the outcomes of different NCDs, predictors of the choice of psychotherapy, and the efficacy of ontopsychological intervention on psychological and medical outcomes. Conclusion: This study will generate data on distinctive psychological characteristics of patients suffering from different CDs and their relationship with medical outcomes, as well as explore the efficacy of ontopsychological STP in these patients in the real world. (Number of registration: NCT03437642).
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- 2021
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16. OC-025 Roc-king onwards: iel counts, distributions, & roles in mucosal interpretation
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Rostami, K, Marsh, MN, Johnson, MW, Srivastava, A, Ensari, A, Holmes, G, Mohaghegh, H, Neefjes-Borst, A, Bozzola, A, Mathews, S, Mulder, CJ, Mandolesi, A, Ferrero, S, Bancel, B, Volta, U, Rostami-Nejad, M, Ali, JI, Ciacci, C, Sotoudeh, M, Goldin, R, Ganji, A, Robert, M, Bassoti, G, Ghafarzadehgan, K, Carroccio, A, Villanacci, V, Catassi, C, Ciobanu, A, Aldulaimi, D, Fiorentino, M, Derakhshan, M, Becheanu, G, Bateman, A, Zali, MR, Russo, I, Fiorino, M, Maxim, R, Danciu, M, Ishaq, S, Elli, L, Going, J, and Heal, C
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IntroductionCounting intraepithelial lymphocytes (IEL) has been a prominent diagnostic histological approach for distinguishing normal disease-control (DC) mucosae from celiac disease (CD) patients for over five decades. Most surprisingly, during that period, no definitive definition of a ”normal” count has ever appeared: indeed, the existing literature on this point is extremely fragile. In this new, multi-centre study, ROC-curve analysis was used to determine the optimal cut-off between normal and CD (Marsh III lesion) mucosae, based on IEL counts on over 400 mucosal biopsy specimens.MethodThe study was designed during the International Meeting on Digestive Pathology, Bucharest 2015 in which investigators from 19 centres from eight countries and involving three continents recruited patients to measure numbers of IEL per 100 enterocytes in well-oriented duodenal biopsies. All centres worked to an agreed protocol to ensure uniformity of approach. Demographic and serological data were also collected, wherever feasible, to compare cases and controls.ResultsThe mean age of DC and CD groups were 38.3 and 45.5 years respectively, of which 59% and 71% were female. The mean IEL count was 54±18/100 enterocytes for CD compared with 13±8 for DC (p=0.0001). ROC-curve analysis indicated an optimal cut-off point of 25 IEL/100 enterocytes, with a sensitivity and specificity of 99% and 92%: the area under the curve was 0.0995. Using this technique we showed that other proposals in the literature, between 20–40 IEL, were far less discriminatory. Additionally, there was a sufficiently high number of biopsies to explore IEL counts across the sub-classification of the Marsh III lesion.ConclusionThe IEL count is not normally-distributed in CD. The numerical overlapping confirmed that IEL do not represent a bi-modally distributed population[s], thus being indicative of a continuously graded dose-response by IEL to environmental (gluten) antigenic influence. In the largest study of this type, we showed using ROC-curve analysis that for Marsh III lesions, a cut-off value of 25 IEL/100 enterocytes is the optimal dividing line between DC and CD biopsies. Finally, we were unable to demonstrate any difference in IEL counts between Marsh Stage III a,b,c, subdivisions, with histology or immunocytochemisty. These results are consistent with a growing literature that finds this sub-classification of little value.Disclosure of InterestNone Declared
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- 2017
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17. CZT-Based Harmonic Analysis in Smart Grid Using Low-Cost Electronic Measurement Boards
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Giovanni Artale, Nicola Panzavecchia, Valentina Cosentino, Antonio Cataliotti, Manel Ben-Romdhane, Amel Benazza-Ben Yahia, Valeria Boscaino, Noureddine Ben Othman, Vito Ditta, Michele Fiorino, Giuseppe Del Mastro, Salvatore Guaiana, Giovanni Tinè, Dario Di Cara, Artale G., Panzavecchia N., Cosentino V., Cataliotti A., Ben-Romdhane M., Benazza-Ben Yahia A., Boscaino V., Ben Othman N., Ditta V., Fiorino M., Del Mastro G., Guaiana S., Tine G., and Di Cara D.
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Control and Optimization ,Renewable Energy, Sustainability and the Environment ,Energy Engineering and Power Technology ,Building and Construction ,power quality ,CZT ,harmonic analysis ,smart grid ,hardware implementation ,low-cost devices ,Electrical and Electronic Engineering ,Engineering (miscellaneous) ,Settore ING-INF/07 - Misure Elettriche E Elettroniche ,Energy (miscellaneous) - Abstract
This paper validates the use of a harmonic analysis algorithm on a microcontroller to perform measurements of non-stationary signals in the context of smart grids. The increasing presence of electronic devices such as inverters of distributed generators (DG), power converters of charging stations for electric vehicles, etc. can drain non-stationary currents during their operation. A classical fast Fourier transform (FFT) algorithm may not have sufficient spectral resolution for the evaluation of harmonics and inter-harmonics. Thus, in this paper, the implementation of a chirp-Z transform (CZT) algorithm is suggested, which has a spectral resolution independent from the observation window. The CZT is implemented on a low-cost commercial microcontroller, and the absolute error is evaluated with respect to the same algorithm implemented in the LabVIEW environment. The results of the tests show that the CZT implementation on a low-cost microcontroller allows for accurate measurement results, demonstrating the feasibility of reliable harmonic analysis measurements even in non-stationary conditions on smart grids.
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- 2023
18. Innovative Solutions for the Integration of Renewable Energies on Tunisian and Sicilian Electrical Grids
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Giovanni Artale, Asma Maalej, Ons Ben Rhouma, Manel Ben-Romdhane, Noureddine Ben Othman, Antonio Cataliotti, Valentina Cosentino, Antonino Culcasi, Michele Fiorino, Salvatore Guaiana, Nicola Panzavecchia, Giovanni Tine, Dario Di Cara, Artale G., Maalej A., Rhouma O.B., Ben-Romdhane M., Othman N.B., Cataliotti A., Cosentino V., Culcasi A., Fiorino M., Guaiana S., Panzavecchia N., Tine G., and Di Cara D.
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power line communication ,Power system communication ,smart grids ,Communication signal ,communication systems ,power system measurements ,Settore ING-INF/07 - Misure Elettriche E Elettroniche - Abstract
The rapid spread of distributed generation from renewable energy sources, combined with their unpredictable behavior, requires the continuous monitoring and control by the Distribution System Operator, in order to guarantee the stability and efficiency of the distribution network. Thus, in this paper a new measurement and communication architecture is proposed, which foresees the use of innovative devices and different technology-oriented solutions, even redundant ones, which allows the transition from passive to active electricity distribution network, with minimal structural changes. The architecture has been developed in the framework of the SInERT project (Italy-Tunisia cross-border cooperation program 2014-2020), which is aimed at proposing innovative solutions to integrate renewable energy on Tunisian electrical grid, sharing knowledge and experience of two demonstrators built in Elgazala Technopark (Ariana, Tunisia) and Ustica (Sicily, Italy).
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- 2022
19. A worldwide survey on proctological practice during COVID-19 lockdown (ProctoLock 2020): a cross-sectional analysis
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Gallo, Gaetano, Sturiale, Alessandro, De Simone, Veronica, Di Tanna, Gian Luca, Giani, Iacopo, Grossi, Ugo, Aiello, Domenico, Bianco, Francesco, Bondurri, Andrea, La Torre, Marco, Milito, Giovanni, Perinotti, Roberto, Pietroletti, Renato, Serventi, Alberto, Fiorino, Marina, Manigrasso, Michele, Zaffaroni, Gloria, Boff, Ferruccio, Cantarella, Francesco, Deidda, Simona, Di Saverio, Salomone, Marino, Fabio, Martellucci, Jacopo, Milone, Marco, Pata, Francesco, Picciariello, Arcangelo, Minaya Bravo, Ana, Vigorita, Vincenzo, Cunha, Miguel Fernandes, Leventoglu, Sezai, Garmanova, Tatiana, Tsarkov, Petr, El‐Hussuna, Alaa, Frontali, Alice, Ioannidis, Argyrios, Bislenghi, Gabriele, Shalaby, Mostafa, Porzio, Felipe Celedon, Wu, Jiong, Zimmerman, David, Elbetti, Claudio, Mayol, Julio, Naldini, Gabriele, Trompetto, Mario, Sammarco, Giuseppe, Santoro, Giulio Aniello, Gallo, G., Sturiale, A., De Simone, V., Di Tanna, G. L., Giani, I., Grossi, U., Aiello, D., Bianco, F., Bondurri, A., La Torre, M., Milito, G., Perinotti, R., Pietroletti, R., Serventi, A., Fiorino, M., Manigrasso, M., Zaffaroni, G., Boff, F., Cantarella, F., Deidda, S., Di Saverio, S., Marino, F., Martellucci, J., Milone, M., Pata, F., Picciariello, A., Minaya Bravo, A., Vigorita, V., Cunha, M. F., Leventoglu, S., Garmanova, T., Tsarkov, P., El-Hussuna, A., Frontali, A., Ioannidis, A., Bislenghi, G., Shalaby, M., Porzio, F. C., Wu, J., Zimmerman, D., Elbetti, C., Mayol, J., Naldini, G., Trompetto, M., Sammarco, G., and Santoro, G. A.
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Adult ,Male ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Cross-sectional study ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,MEDLINE ,SARS-COV-2 ,Practice Patterns ,030230 surgery ,covid-19 ,europe ,italy ,lockdown ,proctolock2020 ,proctology ,sars-cov-2 ,worldwide ,Orginal Article ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Pandemic ,Lockdown ,Medicine ,Orginal Articles ,Humans ,Practice Patterns, Physicians' ,Personal protective equipment ,Digestive System Surgical Procedures ,Physicians' ,business.industry ,Gastroenterology ,COVID-19 ,Middle Aged ,Colorectal surgery ,Europe ,Cross-Sectional Studies ,Italy ,Family medicine ,Respondent ,ProctoLock2020 ,Proctology ,Worldwide ,Colorectal Surgery ,Female ,Communicable Disease Control ,030211 gastroenterology & hepatology ,business - Abstract
Aim Proctology is one of the surgical specialties that has suffered the most during COVID‐19 pandemic. Using a cross‐sectional non‐incentivised World Wide Web survey, we aimed to snapshot the current status of proctological practice in six world regions. Method Surgeons affiliated to renowned scientific societies with an interest in coloproctology were invited to join the survey. Members of the ProctoLock Working Group enhanced recruitment by direct invitation. The predictive power of respondents’ and hospitals’ demographics on the change of status of surgical and outpatient activities was calculated. Results Respondents (n = 1050) were mostly men (79%), with a mean age of 46.9 years, at consultant level (79%), practising in academic hospitals (53%) offering a dedicated proctology service (68%). A total of 119 (11%) tested positive for SARS‐CoV‐2. The majority (54%) came from Europe. Participants from Asia reported a higher proportion of unaltered practice (17%), while those from Europe had the highest proportion of fully stopped practice (20%). The likelihood of ongoing surgical practice was higher in men (OR 1.54, 95% CI 1.13–2.09; P = 0.006), in those reporting readily availability of personal protective equipment (PPE) (OR 1.40, 1.08–1.42; P = 0.012) and in centres that were partially or not at all involved in COVID‐19 care (OR 2.95, 2.14–4.09; P
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- 2021
20. Deadlock of proctologic practice in Italy during COVID-19 pandemic: a national report from ProctoLock2020
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Gallo, Gaetano, Alessandro, Sturiale, Veronica De Simone, Stefano, Mancini, Gian Luca Di Tanna, Giovanni, Milito, Francesco, Bianco, Roberto, Perinotti, Iacopo, Giani, Ugo, Grossi, ProctoLock2020 Working Group, Domenico, Aiello, Andrea, Bondurri, Gaetano, Gallo, Marco La Torre, Renato, Pietroletti, Alberto, Serventi, Marina, Fiorino, Michele, Manigrasso, Gloria, Zaffaroni, Ferruccio, Boffi, Vittoria, Bellato, Francesco, Cantarella, Simona, Deidda, Fabio, Marino, Jacopo, Martellucci, Marco, Milone, Arcangelo, Picciariello, Ana Minaya Bravo, Vincenzo, Vigorita, Miguel Fernandes Cunha, Sezai, Leventoglu, Tatiana, Garmanova, Petr, Tsarkov, Alaa, El-Hussuna, Alice, Frontali, Argyrios, Ioannidis, Gabriele, Bislenghi, Mostafa, Shalaby, Felipe Celedon Porzio, Jiong, Wu, David, Zimmerman, Claudio, Elbetti, Julio, Mayol, Gabriele, Naldini, Mario, Trompetto, Giuseppe, Sammarco, Giulio Aniello Santoro, Gallo, G., Sturiale, A., De Simone, V., Mancini, S., Di Tanna, G. L., Milito, G., Bianco, F., Perinotti, R., Giani, I., Grossi, U., Aiello, D., Bondurri, A., La Torre, M., Pietroletti, R., Serventi, A., Fiorino, M., Manigrasso, M., Zaffaroni, G., Boffi, F., Bellato, V., Cantarella, F., Deidda, S., Marino, F., Martellucci, J., Milone, M., Picciariello, A., Bravo, A. M., Vigorita, V., Cunha, M. F., Leventoglu, S., Garmanova, T., Tsarkov, P., El-Hussuna, A., Frontali, A., Ioannidis, A., Bislenghi, G., Shalaby, M., Porzio, F. C., Wu, J., Zimmerman, D., Elbetti, C., Mayol, J., Naldini, G., Trompetto, M., Sammarco, G., and Santoro, G. A.
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Male ,medicine.medical_specialty ,Demographics ,Coronavirus disease 2019 (COVID-19) ,Infectious Disease Transmission ,SARS-COV-2 ,Health Services Accessibility ,Patient-to-Professional ,03 medical and health sciences ,Hospital ,0302 clinical medicine ,Hospital Administration ,Pandemic ,Lockdown ,Medicine ,Humans ,COVID-19 ,Italy ,ProctoLock2020 ,Proctology ,Pandemics ,Ambulatory Surgical Procedures ,Colorectal Surgery ,Elective Surgical Procedures ,Emergency Service, Hospital ,Female ,Infection Control ,Infectious Disease Transmission, Patient-to-Professional ,Middle Aged ,Health Care Surveys ,Emergency Service ,proctology ,lockdown ,business.industry ,Mean age ,Surgery ,030220 oncology & carcinogenesis ,Family medicine ,030211 gastroenterology & hepatology ,business - Abstract
Proctology is one of the surgical specialties that suffered the most during COVID-19 pandemic. Using data from a cross-sectional worldwide web survey, we aimed to snapshot the current status of proctologic practice in Italy with differences between three macro areas (North, Centre, South). Specialists affiliated to renowned scientific societies with an interest in coloproctology were invited to join a 27-item survey. Predictive power of respondents’ and hospitals’ demographics on the change of status of surgical activities was calculated. The study was registered at ClinicalTrials.gov (NCT 04392245). Of 299 respondents from Italy, 94 (40%) practiced in the North, 60 (25%) in the Centrer and 82 (35%) in the South and Islands. The majority were men (79%), at consultant level (70%), with a mean age of 46.5 years, practicing in academic hospitals (39%), where a dedicated proctologist was readily available (68%). Southern respondents were more at risk of infection compared to those from the Center (OR, 3.30; 95%CI 1.46; 7.47, P = 0.004), as were males (OR, 2.64; 95%CI 1.09; 6.37, P = 0.031) and those who routinely tested patients prior to surgery (OR, 3.02; 95%CI 1.39; 6.53, P = 0.005). The likelihood of ongoing surgical practice was higher in the South (OR 1.36, 95%CI 0.75; 2.46, P = 0.304) and in centers that were not fully dedicated to COVID-19 care (OR 4.00, 95%CI 1.88; 8.50, P
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- 2020
21. ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation
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Ilaria Russo, Andra Neefjes-Borst, Kamran Ghaffarzadehgan, Vincenzo Villanacci, Anna Bozzola, Matt W Johnson, Azita Ganji, Mohammad H. Derakhshan, Alessandra Mandolesi, Alexandra Ciobanu, Angelo Sidoni, Arzu Ensari, Geoffrey Holmes, Marie E. Robert, Marilena Fiorino, Michael N. Marsh, Stefano Ferrero, James J. Going, Masoud Sotoudeh, David Aldulaimi, Kamran Rostami, Hamid Mohaghegh, Mihai Danciu, Carlo Catassi, Antonio Carroccio, Chris J. J. Mulder, Brigitte Bancel, Amitabh Srivastava, Calvin Heal, Gabrio Bassotti, Carolina Ciacci, Sauid Ishaq, Luca Elli, Mohammad Reza Zali, Mohammad Rostami-Nejad, Adrian C Bateman, Umberto Volta, Roxana Maxim, Michelangelo Fiorentino, Gabriel Becheanu, Sherly Mathews, Rostami, Kamran, Marsh, Michael N, Johnson, Matt W, Mohaghegh, Hamid, Heal, Calvin, Holmes, Geoffrey, Ensari, Arzu, Aldulaimi, David, Bancel, Brigitte, Bassotti, Gabrio, Bateman, Adrian, Becheanu, Gabriel, Bozzola, Anna, Carroccio, Antonio, Catassi, Carlo, Ciacci, Carolina, Ciobanu, Alexandra, Danciu, Mihai, Derakhshan, Mohammad H, Elli, Luca, Ferrero, Stefano, Fiorentino, Michelangelo, Fiorino, Marilena, Ganji, Azita, Ghaffarzadehgan, Kamran, Going, James J, Ishaq, Sauid, Mandolesi, Alessandra, Mathews, Sherly, Maxim, Roxana, Mulder, Chris J, Neefjes-borst, Andra, Robert, Marie, Russo, Ilaria, Rostami-nejad, Mohammad, Sidoni, Angelo, Sotoudeh, Masoud, Villanacci, Vincenzo, Volta, Umberto, Zali, Mohammad R, Srivastava, Amitabh, Gastroenterology and hepatology, AGEM - Re-generation and cancer of the digestive system, AGEM - Endocrinology, metabolism and nutrition, AGEM - Digestive immunity, Pathology, Other Research, and Rostami K, Marsh MN, Johnson MW, Mohaghegh H, Heal C, Holmes G, Ensari A, Aldulaimi D, Bancel B, Bassotti G, Bateman A, Becheanu G, Bozzola A, Carroccio A, Catassi C, Ciacci C, Ciobanu A, Danciu M, Derakhshan MH, Elli L, Ferrero S, Fiorentino M, Fiorino M, Ganji A, Ghaffarzadehgan K, Going JJ, Ishaq S, Mandolesi A, Mathews S, Maxim R, Mulder CJ, Neefjes-Borst A, Robert M, Russo I, Rostami-Nejad M, Sidoni A, Sotoudeh M, Villanacci V, Volta U, Zali MR, Srivastava A.
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Male ,Pathology ,Settore MED/09 - Medicina Interna ,ROC-curve analysi ,Biopsy ,Coeliac disease ,Serology ,0302 clinical medicine ,intraepithelial lymphocytes ,Diagnosis ,80 and over ,ROC-curve analysis ,coeliac disease ,Lymphocytes ,Intestinal Mucosa ,Child ,medicine.diagnostic_test ,Area under the curve ,Gastroenterology ,hemic and immune systems ,Middle Aged ,Prognosis ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Female ,medicine.symptom ,tissues ,Adult ,medicine.medical_specialty ,Adolescent ,chemical and pharmacologic phenomena ,Biology ,digestive system ,Lesion ,03 medical and health sciences ,medicine ,Humans ,Lymphocyte Count ,Preschool ,Aged ,Receiver operating characteristic ,Infant ,Histology ,medicine.disease ,Newborn ,Aged, 80 and over ,Case-Control Studies ,Celiac Disease ,Child, Preschool ,Diagnosis, Differential ,Infant, Newborn ,ROC Curve ,Differential ,Intraepithelial lymphocyte - Abstract
ObjectivesCounting intraepithelial lymphocytes (IEL) is central to the histological diagnosis of coeliac disease (CD), but no definitive ‘normal’ IEL range has ever been published. In this multicentre study, receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off between normal and CD (Marsh III lesion) duodenal mucosa, based on IEL counts on >400 mucosal biopsy specimens.DesignThe study was designed at the International Meeting on Digestive Pathology, Bucharest 2015. Investigators from 19 centres, eight countries of three continents, recruited 198 patients with Marsh III histology and 203 controls and used one agreed protocol to count IEL/100 enterocytes in well-oriented duodenal biopsies. Demographic and serological data were also collected.ResultsThe mean ages of CD and control groups were 45.5 (neonate to 82) and 38.3 (2–88) years. Mean IEL count was 54±18/100 enterocytes in CD and 13±8 in normal controls (p=0.0001). ROC analysis indicated an optimal cut-off point of 25 IEL/100 enterocytes, with 99% sensitivity, 92% specificity and 99.5% area under the curve. Other cut-offs between 20 and 40 IEL were less discriminatory. Additionally, there was a sufficiently high number of biopsies to explore IEL counts across the subclassification of the Marsh III lesion.ConclusionOur ROC curve analyses demonstrate that for Marsh III lesions, a cut-off of 25 IEL/100 enterocytes optimises discrimination between normal control and CD biopsies. No differences in IEL counts were found between Marsh III a, b and c lesions. There was an indication of a continuously graded dose–response by IEL to environmental (gluten) antigenic influence.
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- 2017
22. Stress Echocardiography in Italian Echocardiographic Laboratories: A Survey of the Italian Society of Echocardiography and Cardiovascular Imaging.
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Ciampi Q, Pepi M, Antonini-Canterin F, Barbieri A, Barchitta A, Faganello G, Miceli S, Parato VM, Tota A, Trocino G, Abbate M, Accadia M, Alemanni R, Angelini A, Anglano F, Anselmi M, Aquila I, Aramu S, Avogadri E, Azzaro G, Badano L, Balducci A, Ballocca F, Barbarossa A, Barbati G, Barletta V, Barone D, Becherini F, Benfari G, Beraldi M, Bergandi G, Bilardo G, Binno SM, Bolognesi M, Bongiovi S, Bragato RM, Braggion G, Brancaleoni R, Bursi F, Dessalvi CC, Cameli M, Canu A, Capitelli M, Capra ACM, Carbonara R, Carbone M, Carbonella M, Carrabba N, Casavecchia G, Casula M, Chesi E, Cicco S, Citro R, Cocchia R, Colombo BM, Colonna P, Conte M, Corrado G, Cortesi P, Cortigiani L, Costantino MF, Cozza F, Cucchini U, D'Angelo M, Da Ros S, D'Andrea F, D'Andrea A, D'Auria F, De Caridi G, De Feo S, De Matteis GM, De Vecchi S, Del Giudice C, Dell'Angela L, Paoli LD, Dentamaro I, Destefanis P, Di Bella G, Di Fulvio M, Di Gaetano R, Di Giannuario G, Di Gioia A, Di Martino LFM, Di Muro C, Di Nora C, Di Salvo G, Dodi C, Dogliani S, Donati F, Dottori M, Epifani G, Fabiani I, Ferrara F, Ferrara L, Ferrua S, Filice G, Fiorino M, Forno D, Garini A, Giarratana GA, Gigantino G, Giorgi M, Giubertoni E, Greco CA, Grigolato M, Marra WG, Holzl A, Iaiza A, Iannaccone A, Ilardi F, Imbalzano E, Inciardi RM, Inserra CA, Iori E, Izzo A, La Rosa G, Labanti G, Lanzone AM, Lanzoni L, Lapetina O, Leiballi E, Librera M, Conte CL, Monaco ML, Lombardo A, Luciani M, Lusardi P, Magnante A, Malagoli A, Malatesta G, Mancusi C, Manes MT, Manganelli F, Mantovani F, Manuppelli V, Marchese V, Marinacci L, Mattioli R, Maurizio C, Mazza GA, Mazza S, Melis M, Meloni G, Merli E, Milan A, Minardi G, Monaco A, Monte I, Montresor G, Moreo A, Mori F, Morini S, Moro C, Morrone D, Negri F, Nipote C, Nisi F, Nocco S, Novello L, Nunziata L, Perini AP, Parodi A, Pasanisi EM, Pastorini G, Pavasini R, Pavoni D, Pedone C, Pelliccia F, Pelliciari G, Pelloni E, Pergola V, Perillo G, Petruccelli E, Pezzullo C, Piacentini G, Picardi E, Pinna G, Pizzarelli M, Pizzuti A, Poggi MM, Posteraro A, Privitera C, Rampazzo D, Ratti C, Rettegno S, Ricci F, Ricci C, Rolando C, Rossi S, Rovera C, Ruggieri R, Russo MG, Sacchi N, Saladino A, Sani F, Sartori C, Scarabeo V, Sciacqua A, Scillone A, Scopelliti PA, Scorza A, Scozzafava A, Serafini F, Serra W, Severino S, Simeone B, Sirico D, Solari M, Spadaro GL, Stefani L, Strangio A, Surace FC, Tamborini G, Tarquinio N, Tassone EJ, Tavarozzi I, Tchana B, Tedesco G, Tinto M, Torzillo D, Totaro A, Triolo OF, Troisi F, Tusa M, Vancheri F, Varasano V, Venezia A, Vermi AC, Villari B, Zampi G, Zannoni J, Zito C, Zugaro A, Picano E, and Carerj S
- Abstract
Background: The Italian Society of Echography and Cardiovascular Imaging (SIECVI) conducted a national survey to understand the volumes of activity, modalities and stressors used during stress echocardiography (SE) in Italy., Methods: We analyzed echocardiography laboratory activities over a month (November 2022). Data were retrieved through an electronic survey based on a structured questionnaire, uploaded on the SIECVI website., Results: Data were obtained from 228 echocardiographic laboratories, and SE examinations were performed in 179 centers (80.6%): 87 centers (47.5%) were in the northern regions of Italy, 33 centers (18.4%) were in the central regions, and 61 (34.1%) in the southern regions. We annotated a total of 4057 SE. We divided the SE centers into three groups, according to the numbers of SE performed: <10 SE (low-volume activity, 40 centers), between 10 and 39 SE (moderate volume activity, 102 centers) and ≥40 SE (high volume activity, 37 centers). Dipyridamole was used in 139 centers (77.6%); exercise in 120 centers (67.0%); dobutamine in 153 centers (85.4%); pacing in 37 centers (21.1%); and adenosine in 7 centers (4.0%). We found a significant difference between the stressors used and volume of activity of the centers, with a progressive increase in the prevalence of number of stressors from low to high volume activity ( P = 0.033). The traditional evaluation of regional wall motion of the left ventricle was performed in all centers, with combined assessment of coronary flow velocity reserve (CFVR) in 90 centers (50.3%): there was a significant difference in the centers with different volume of SE activity: the incidence of analysis of CFVR was significantly higher in high volume centers compared to low - moderate - volume (32.5%, 41.0% and 73.0%, respectively, P < 0.001). The lung ultrasound (LUS) was assessed in 67 centers (37.4%). Furthermore for LUS, we found a significant difference in the centers with different volume of SE activity: significantly higher in high volume centers compared to low - moderate - volume (25.0%, 35.3% and 56.8%, respectively, P < 0.001)., Conclusions: This nationwide survey demonstrated that SE was significantly widespread and practiced throughout Italy. In addition to the traditional indication to coronary artery disease based on regional wall motion analysis, other indications are emerging with an increase in the use of LUS and CFVR, especially in high-volume centers., Competing Interests: There are no conflicts of interest., (Copyright: © 2023 Journal of Cardiovascular Echography.)
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- 2023
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23. Utility of a buccal swab point-of-care test for the IFNL4 genotype in the era of direct acting antivirals for hepatitis C virus.
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Sy A, McCabe L, Hudson E, Ansari AM, Pedergnana V, Lin SK, Santana S, Fiorino M, Ala A, Stone B, Smith M, Nelson M, Barclay ST, McPherson S, Ryder SD, Collier J, Barnes E, Walker AS, Pett SL, and Cooke G
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- Humans, Hepacivirus genetics, Polymorphism, Single Nucleotide, Interleukins genetics, Genotype, Interferons therapeutic use, Point-of-Care Testing, Antiviral Agents therapeutic use, Hepatitis C, Chronic drug therapy
- Abstract
Background: The CC genotype of the IFNL4 gene is known to be associated with increased Hepatitis C (HCV) cure rates with interferon-based therapy and may contribute to cure with direct acting antivirals. The Genedrive® IFNL4 is a CE marked Point of Care (PoC) molecular diagnostic test, designed for in vitro diagnostic use to provide rapid, real-time detection of IFNL4 genotype status for SNP rs12979860., Methods: 120 Participants were consented to a substudy comparing IFNL4 genotyping results from a buccal swab analysed on the Genedrive® platform with results generated using the Affymetix UK Biobank array considered to be the gold standard., Results: Buccal swabs were taken from 120 participants for PoC IFNL4 testing and a whole blood sample for genetic sequencing. Whole blood genotyping vs. buccal swab PoC testing identified 40 (33%), 65 (54%), and 15 (13%) had CC, CT and TT IFNL4 genotype respectively. The Buccal swab PoC identified 38 (32%) CC, 64 (53%) CT and 18 (15%) TT IFNL4 genotype respectively. The sensitivity and specificity of the buccal swab test to detect CC vs non-CC was 90% (95% CI 76-97%) and 98% (95% CI 91-100%) respectively., Conclusions: The buccal swab test was better at correctly identifying non-CC genotypes than CC genotypes. The high specificity of the Genedrive® assay prevents CT/TT genotypes being mistaken for CC, and could avoid patients being identified as potentially 'good responders' to interferon-based therapy., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Sy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2023
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24. Organization and Activity of Italian Echocardiographic Laboratories: A Survey of the Italian Society of Echocardiography and Cardiovascular Imaging.
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Ciampi Q, Pepi M, Antonini-Canterin F, Barbieri A, Barchitta A, Faganello G, Miceli S, Parato VM, Tota A, Trocino G, Abbate M, Accadia M, Alemanni R, Angelini A, Anglano F, Anselmi M, Aquila I, Aramu S, Avogadri E, Azzaro G, Badano L, Balducci A, Ballocca F, Barbarossa A, Barbati G, Barletta V, Barone D, Becherini F, Benfari G, Beraldi M, Bergandi G, Bilardo G, Binno SM, Bolognesi M, Bongiovi S, Bragato RM, Braggion G, Brancaleoni R, Bursi F, Dessalvi CC, Cameli M, Canu A, Capitelli M, Capra ACM, Carbonara R, Carbone M, Carbonella M, Carrabba N, Casavecchia G, Casula M, Chesi E, Cicco S, Citro R, Cocchia R, Colombo BM, Colonna P, Conte M, Corrado G, Cortesi P, Cortigiani L, Costantino MF, Cozza F, Cucchini U, D'Angelo M, Ros SD, D'Andrea F, D'Andrea A, D'Auria F, De Caridi G, De Feo S, De Matteis GM, De Vecchi S, Giudice CD, Dell'Angela L, Paoli LD, Dentamaro I, Destefanis P, Di Fulvio M, Di Gaetano R, Di Giannuario G, Di Gioia A, Di Martino LFM, Di Muro C, Di Nora C, Di Salvo G, Dodi C, Dogliani S, Donati F, Dottori M, Epifani G, Fabiani I, Ferrara F, Ferrara L, Ferrua S, Filice G, Fiorino M, Forno D, Garini A, Giarratana GA, Gigantino G, Giorgi M, Giubertoni E, Greco CA, Grigolato M, Marra WG, Holzl A, Iaiza A, Iannaccone A, Ilardi F, Imbalzano E, Inciardi R, Inserra CA, Iori E, Izzo A, Rosa G, Labanti G, Lanzone AM, Lanzoni L, Lapetina O, Leiballi E, Librera M, Conte CL, Monaco ML, Lombardo A, Luciani M, Lusardi P, Magnante A, Malagoli A, Malatesta G, Mancusi C, Manes MT, Manganelli F, Mantovani F, Manuppelli V, Marchese V, Marinacci L, Mattioli R, Maurizio C, Mazza GA, Mazza S, Melis M, Meloni G, Merli E, Milan A, Minardi G, Monaco A, Monte I, Montresor G, Moreo A, Mori F, Morini S, Moro C, Morrone D, Negri F, Nipote C, Nisi F, Nocco S, Novello L, Nunziata L, Perini AP, Parodi A, Pasanisi EM, Pastorini G, Pavasini R, Pavoni D, Pedone C, Pelliccia F, Pelliciari G, Pelloni E, Pergola V, Perillo G, Petruccelli E, Pezzullo C, Piacentini G, Picardi E, Pinna G, Pizzarelli M, Pizzuti A, Poggi MM, Posteraro A, Privitera C, Rampazzo D, Ratti C, Rettegno S, Ricci F, Ricci C, Rolando C, Rossi S, Rovera C, Ruggieri R, Russo MG, Sacchi N, Saladino A, Sani F, Sartori C, Scarabeo V, Sciacqua A, Scillone A, Scopelliti PA, Scorza A, Scozzafava A, Serafini F, Serra W, Severino S, Simeone B, Sirico D, Solari M, Spadaro GL, Stefani L, Strangio A, Surace FC, Tamborini G, Tarquinio N, Tassone EJ, Tavarozzi I, Tchana B, Tedesco G, Tinto M, Torzillo D, Totaro A, Triolo OF, Troisi F, Tusa M, Vancheri F, Varasano V, Venezia A, Vermi AC, Villari B, Zampi G, Zannoni J, Zito C, Zugaro A, Di Bella G, and Carerj S
- Abstract
Background: The Italian Society of Echocardiography and Cardiovascular Imaging (SIECVI) conducted a national survey to understand better how different echocardiographic modalities are used and accessed in Italy., Methods: We analyzed echocardiography laboratory activities over a month (November 2022). Data were retrieved via an electronic survey based on a structured questionnaire, uploaded on the SIECVI website., Results: Data were obtained from 228 echocardiographic laboratories: 112 centers (49%) in the northern, 43 centers (19%) in the central, and 73 (32%) in the southern regions. During the month of observation, we collected 101,050 transthoracic echocardiography (TTE) examinations performed in all centers. As concern other modalities there were performed 5497 transesophageal echocardiography (TEE) examinations in 161/228 centers (71%); 4057 stress echocardiography (SE) examinations in 179/228 centers (79%); and examinations with ultrasound contrast agents (UCAs) in 151/228 centers (66%). We did not find significant regional variations between the different modalities. The usage of picture archiving and communication system (PACS) was significantly higher in the northern (84%) versus central (49%) and southern (45%) centers ( P < 0.001). Lung ultrasound (LUS) was performed in 154 centers (66%), without difference between cardiology and noncardiology centers. The evaluation of left ventricular (LV) ejection fraction was evaluated mainly using the qualitative method in 223 centers (94%), occasionally with the Simpson method in 193 centers (85%), and with selective use of the three-dimensional (3D) method in only 23 centers (10%). 3D TTE was present in 137 centers (70%), and 3D TEE in all centers where TEE was done (71%). The assessment of LV diastolic function was done routinely in 80% of the centers. Right ventricular function was evaluated using tricuspid annular plane systolic excursion in all centers, using tricuspid valve annular systolic velocity by tissue Doppler imaging in 53% of the centers, and using fractional area change in 33% of the centers. When we divided into cardiology (179, 78%) and noncardiology (49, 22%) centers, we found significant differences in the SE (93% vs. 26%, P < 0.001), TEE (85% vs. 18%), UCA (67% vs. 43%, P < 0001), and STE (87% vs. 20%, P < 0.001). The incidence of LUS evaluation was similar between the cardiology and noncardiology centers (69% vs. 61%, P = NS)., Conclusions: This nationwide survey demonstrated that digital infrastructures and advanced echocardiography modalities, such as 3D and STE, are widely available in Italy with a notable diffuse uptake of LUS in the core TTE examination, a suboptimal diffusion of PACS recording, and conservative use of UCA, 3D, and strain. There are significant differences between northern and central-southern regions and echocardiographic laboratories that pertain to the cardiac unit. This inhomogeneous distribution of technology represents one of the main issues that must be solved to standardize the practice of echocardiography., Competing Interests: There are no conflicts of interest., (Copyright: © 2023 Journal of Cardiovascular Echography.)
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- 2023
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25. Dementia in the era of COVID-19. Some considerations and ethical issues.
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Cipriani G, Di Fiorino M, and Cammisuli DM
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- Female, Humans, Male, Pandemics, SARS-CoV-2, COVID-19, Dementia epidemiology
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Living with dementia at any time brings everyday challenges for the patient and those around him/her. The Covid-19 pandemic is making daily life harder. We aim to describe the problems of people with dementia during the time of such a pandemic and address the issue of their access to intensive care units. A systematic literature search (Cochrane Library (advanced search), and PubMed) was performed (for items up to 19 August 2020) using the following terms: 'COVID-19', 'dementia', and 'intensive care unit'. Studies were independently evaluated and selected for potential analysis. Five of 35 articles initially selected met the inclusion criteria. An additional Google Scholar search identified some striking statements from relevant authorities or scientists about the difficulty of living with dementia in the era of COVID-19, and were also reported. To summarize, dementia-related behaviours, increased age, and comorbid health conditions may increase the risk of contracting the virus. People with dementia in their own homes may already feel isolated, and additional rules for self-isolation may make this worse. As COVID-19 is spreading worldwide, governments and health authorities should devise better criteria for accessing intensive care units and allocating ventilators. If someone is given preference for medical care, it should be because that person has a better short-term prognosis, not simply because that person is younger than someone else., (© 2021 Japanese Psychogeriatric Society.)
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- 2022
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26. Categorising a problem: alcohol and dementia.
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Cipriani G, Nuti A, Carlesi C, Lucetti C, Di Fiorino M, and Danti S
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- Alcoholism psychology, Animals, Brain drug effects, Cognition Disorders diagnostic imaging, Cognition Disorders etiology, Cognition Disorders psychology, Dementia psychology, Diagnostic and Statistical Manual of Mental Disorders, Ethanol adverse effects, Humans, Alcoholism complications, Alcoholism diagnostic imaging, Brain diagnostic imaging, Dementia diagnostic imaging, Dementia etiology
- Abstract
Alcoholism is a chronic relapsing disorder that can include extended periods of abstinence followed by relapse to heavy drinking. Decades of evidence have clearly shown that long-term, chronic ethanol exposure produces brain damage in humans. The article aims to review the relationship between alcohol use and dementia. Medline and Google Scholar searches were conducted for relevant articles, chapters and books published until 2019. Search terms used included alcohol consumption, alcohol-related dementia, alcohol use disorders, chronic alcoholism, dementia. Publications found through this indexed search were reviewed for further relevant references. Alcohol acts on the central nervous system via both direct and indirect effects, frequently a combination of the two. There is consensus that alcohol contributes to the acquisition of cognitive deficits in late life. However, there are doubts regarding the aetiopathogenesis, nosological status and prevalence of alcohol-related dementia and still, there is much debate over how much alcohol consumption will lead to alcohol-related dementia.
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- 2021
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27. Deadlock of proctologic practice in Italy during COVID-19 pandemic: a national report from ProctoLock2020.
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Gallo G, Sturiale A, De Simone V, Mancini S, Di Tanna GL, Milito G, Bianco F, Perinotti R, Giani I, Grossi U, Aiello D, Bianco F, Bondurri A, Gallo G, La Torre M, Milito G, Perinotti R, Pietroletti R, Serventi A, Fiorino M, De Simone V, Grossi U, Manigrasso M, Sturiale A, Zaffaroni G, Boffi F, Bellato V, Cantarella F, Deidda S, Marino F, Martellucci J, Milone M, Picciariello A, Bravo AM, Vigorita V, Cunha MF, Leventoglu S, Garmanova T, Tsarkov P, El-Hussuna A, Frontali A, Ioannidis A, Bislenghi G, Shalaby M, Porzio FC, Wu J, Zimmerman D, Elbetti C, Mayol J, Naldini G, Trompetto M, Sammarco G, and Santoro GA
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- Ambulatory Surgical Procedures statistics & numerical data, COVID-19 prevention & control, COVID-19 transmission, Elective Surgical Procedures statistics & numerical data, Emergency Service, Hospital statistics & numerical data, Female, Hospital Administration, Humans, Infection Control, Infectious Disease Transmission, Patient-to-Professional prevention & control, Italy epidemiology, Male, Middle Aged, Pandemics, COVID-19 epidemiology, Colorectal Surgery statistics & numerical data, Health Care Surveys, Health Services Accessibility
- Abstract
Proctology is one of the surgical specialties that suffered the most during COVID-19 pandemic. Using data from a cross-sectional worldwide web survey, we aimed to snapshot the current status of proctologic practice in Italy with differences between three macro areas (North, Centre, South). Specialists affiliated to renowned scientific societies with an interest in coloproctology were invited to join a 27-item survey. Predictive power of respondents' and hospitals' demographics on the change of status of surgical activities was calculated. The study was registered at ClinicalTrials.gov (NCT04392245). Of 299 respondents from Italy, 94 (40%) practiced in the North, 60 (25%) in the Centrer and 82 (35%) in the South and Islands. The majority were men (79%), at consultant level (70%), with a mean age of 46.5 years, practicing in academic hospitals (39%), where a dedicated proctologist was readily available (68%). Southern respondents were more at risk of infection compared to those from the Center (OR, 3.30; 95%CI 1.46; 7.47, P = 0.004), as were males (OR, 2.64; 95%CI 1.09; 6.37, P = 0.031) and those who routinely tested patients prior to surgery (OR, 3.02; 95%CI 1.39; 6.53, P = 0.005). The likelihood of ongoing surgical practice was higher in the South (OR 1.36, 95%CI 0.75; 2.46, P = 0.304) and in centers that were not fully dedicated to COVID-19 care (OR 4.00, 95%CI 1.88; 8.50, P < 0.001). The results of this survey highlight important factors contributing to the deadlock of proctologic practice in Italy and may inform the development of future management strategies.
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- 2020
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28. A complication of coronavirus disease 2019: delirium.
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Cipriani G, Danti S, Nuti A, Carlesi C, Lucetti C, and Di Fiorino M
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- Betacoronavirus, COVID-19, Humans, Pandemics, SARS-CoV-2, Coronavirus Infections complications, Delirium virology, Pneumonia, Viral complications
- Abstract
COVID-19 is predominantly a respiratory disease. However, some cases exhibit other features including Central Nervous System symptoms. In the older adult, COVID-19 may present with atypical symptoms, including delirium and its complications. The objective of this study is to describe the relationship between the new type of coronavirus infection and delirium. Systematic research (Cochrane Library and PubMed) was carried out (only upper time limit: April 2020). Publications found through this indexed search were reviewed and manually screened to identify relevant studies. Search terms used included "COVID-19, Delirium, Dementia, Intensive Care Unit". We manually added articles identified through other sources (i.e., key journals). Older people are at the greatest risk from COVID-19. If infected, they may present delirium. Moreover, it is not exclusive to older people. Delirium is not inevitable; rather, it is preventable. Delirium prevention programs are even more crucial in the era of COVID-19 and cannot be allowed to wither despite the challenges of integrating delirium prevention with COVID-19 care. An acute change in condition, behaviour, or mental status should prompt a delirium screen. As regards the treatment, it is advisable to use non-pharmacological interventions first where possible. Medication may be needed for patients with agitation where there is intractable distress or high risk to self/others.
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- 2020
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29. Is that schizophrenia or frontotemporal dementia? Supporting clinicians in making the right diagnosis.
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Cipriani G, Danti S, Nuti A, Di Fiorino M, and Cammisuli DM
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- Cognitive Dysfunction psychology, Diagnosis, Differential, Frontotemporal Dementia psychology, Humans, Neuropsychological Tests, Cognitive Dysfunction diagnosis, Frontotemporal Dementia diagnosis, Schizophrenia diagnosis, Social Cognition
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Schizophrenia (SCH) and frontotemporal dementia (FTD) are neurobehavioral syndromes characterized by a profound alteration in personal and social conduct. Differential diagnosis between SCH and FTD remains a challenge. In this short narrative review, we summarize evidences regarding similarities and differences between these disorders to support clinicians in making the right diagnosis. Reports of FTD misdiagnosed as schizophrenia or schizophrenia-like psychosis are frequently reported in the literature. The behavioural variant of FTD (bvFTD) along with familial FTD characterized by delusions and hallucinations represent the medical conditions that best illustrate overlaps between psychiatry and neurology. Neuropsychological patterns of core deficits and anatomical and physiological brain alterations primarily concur in differencing such disorders while additional research on genetic alterations and their reflection on clinical phenotypes should be implemented in the near future. In some cases, a correct diagnosis should be made within an interdisciplinary clinical setting by complementary competences and follow-up visits to evaluate pathology evolution.
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- 2020
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30. Phenolic Substances in Foods and Anticarcinogenic Properties: A Public Health Perspective.
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Laganà P, Coniglio MA, Fiorino M, Delgado AM, Chammen N, Issaoui M, Gambuzza ME, Iommi C, Soraci L, Haddad MA, and Delia S
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- Anti-Inflammatory Agents, Antioxidants, Humans, Polyphenols, Phenols, Public Health
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The interest in polyphenols from vegetable sources has been progressively increased because of the demonstrated correlation between their abundance in certain foods or food preparations of traditional importance and heritage, and the answer of anti-inflammatory strategies in hospitalized patients in the presence of polypehnol-rich foods (as a complementary therapy). Consequently, research involving the accessory role of polyphenols as anti-tumoral aids have been carried out with the aim of finding new additional strategies. The purpose of this paper to evaluate the role of phenolic compounds in foods with reference to health effects for human beings. The importance of these molecules has been evaluated by the health and safety perspectives in terms of: fight to cardiovascular diseases; prevention of chronic-degenerative disorders; general antioxidant properties; and anticarcinogenic features. Moreover, the role of polyphenols-rich foods as anticancer agents has been discussed with relation to two distinct "action plans" on the public hygiene level: the promotion of human health on the one side (for non-hospitalized and normal subjects), and reliable contrasting strategies in cancer patients., (© AOAC INTERNATIONAL 2020. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
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- 2020
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31. Uncommon and/or bizarre features of dementia: part IV.
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Cipriani G, Nuti A, Danti S, Carlesi C, Cammisuli DM, and Di Fiorino M
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- Humans, Dementia complications, Dementia psychology
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It is well established that the clinical picture of dementias is not clinically homogeneous. For example, non-amnestic presentations of Alzheimer's disease have been referred to as a typical variant. Careful examination of clinical characteristics contributes to understanding the neurobiology of Alzheimer's disease and other dementias and may in turn enhance knowledge of the potential risk factors involved. This study aimed at describing uncommon or bizarre symptoms/syndromes observed in patients suffering from dementia. Medline and Google scholar searches were conducted for relevant articles, chapters, and books published before 2019. Search terms used included dementia, déjà vu, zoophilia, pathological lying, and somatic symptom disorder. Publications found through this indexed search were reviewed for further relevant references. Uncommon/bizarre features of dementia were described as case reports and there were no systematic investigations.
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- 2019
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32. Natural Polyphenols: Chemical Classification, Definition of Classes, Subcategories, and Structures.
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Singla RK, Dubey AK, Garg A, Sharma RK, Fiorino M, Ameen SM, Haddad MA, and Al-Hiary M
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- Molecular Structure, Polyphenols chemistry, Polyphenols classification
- Abstract
Background: Polyphenols are natural compounds synthesized exclusively by plants with chemical features related to phenolic substances and eliciting strong antioxidants properties. Objective: The aim of this paper is to give a reliable overview of the chemical classification of natural polyphenols. Methods: Literature survey was done through google scholar, pubmed and scopus search engine. Results and Discussion: These molecules or classes of natural substances are characterized by two phenyl rings at least and one or more hydroxyl substituents. This description comprehends a large number of heterogeneous compounds with reference to their complexity. Therefore, polyphenols can be simply classified into flavonoids and non-flavonoids, or be subdivided in many sub-classes depending on the number of phenol units within their molecular structure, substituent groups, and/or the linkage type between phenol units. Polyphenols are widely distributed in plant tissues where they mainly exist in form of glycosides or aglycones. The structural diversity of flavonoid molecules arises from variations in hydroxylation pattern and oxidation state resulting in a wide range of compounds: flavanols, anthocyanidins, anthocyanins, isoflavones, flavones, flavonols, flavanones, and flavanonols.
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- 2019
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33. Euthanasia and other end of life in patients suffering from dementia.
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Cipriani G and Di Fiorino M
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- Advance Directives, Cultural Characteristics, Decision Making, Humans, Mental Competency, Stress, Psychological, Dementia, Suicide, Assisted ethics
- Abstract
Medicine aims to relieve patient suffering and cure illness. To relieve suffering is the heart of what doctors do. However, respect for individual autonomy and self-determination are fundamental principles in Western medical ethics and decision-making, often expressed as a desire for control over the timing and manner of death. Patients who become demented often formulate advance euthanasia and assisted suicide directives. Dealing with such request is quite complex because of the specific medical and conflicting ethical questions they raise. Some specific medical and ethical issues arise regarding these substantive requirements when evaluating the euthanasia request of a person suffering from dementia. In jurisdictions that allow euthanasia, the most fundamental prerequisite for a person to make autonomous decisions is capacity. Whether anyone with moderate or severe dementia, and even some with mild dementia, could be deemed to be competent by these criteria is debatable, but during the course of their disease people with dementia sooner or later lose their capacity to make self-determined decisions., (Copyright © 2019. Published by Elsevier B.V.)
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- 2019
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34. Review of the Role of Fluid Dairy in Delivery of Polyphenolic Compounds in the Diet: Chocolate Milk, Coffee Beverages, Matcha Green Tea, and Beyond.
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Bhagat AR, Delgado AM, Issaoui M, Chammem N, Fiorino M, Pellerito A, and Natalello S
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- Animals, Anti-Infective Agents chemistry, Anti-Infective Agents metabolism, Anti-Infective Agents pharmacology, Antioxidants chemistry, Antioxidants metabolism, Antioxidants pharmacology, Bacteria drug effects, Gastrointestinal Microbiome drug effects, Humans, Milk metabolism, Milk Proteins metabolism, Polyphenols metabolism, Polyphenols pharmacology, Protein Binding, Cacao chemistry, Coffee chemistry, Milk chemistry, Milk Proteins chemistry, Polyphenols chemistry, Tea chemistry
- Abstract
Dairy-based functional beverages have been a growing segment as consumer demands for health foods have shifted focus from simply enhancing lifespan to protecting health. Green tea is often limited in use because of poor bioavailability and disagreeable taste. However, milk is considered an ideal platform for the delivery of active polyphenolic compounds in green tea. Furthermore, the antioxidant enzymatic activity and antioxidant index of polyphenols in green tea have been known to be protected through interaction with dairy proteins inside the unstable intestinal environment. In addition, consumption of green tea infused with milk has been found to have a significant impact on reducing skin wrinkles and roughness in elderly subjects, through a decrease in lipid peroxidation and a concomitant reduction in oxidative stress. A similar affinity has been observed between antioxidants in coffee and milk proteins. Dark chocolate has been known to contain significant phenolic content and antioxidant activity. The activation of protein complex NF-κB, which is responsible for cell survival, was found to be significantly reduced upon consumption of cocoa with water, whereas consuming cocoa with milk had no effect on the bioavailability of the phenolic compounds in cocoa. The popularity of dairy as the source for polyphenol fortified beverages in the diet will be dictated by optimization of the technology for maximizing the bioavailability of the antioxidants.
- Published
- 2019
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35. 'I am dead': Cotard syndrome and dementia.
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Cipriani G, Nuti A, Danti S, Picchi L, and Di Fiorino M
- Subjects
- Delusions etiology, Dementia complications, Humans, Syndrome, Delusions physiopathology, Dementia physiopathology
- Abstract
Background: Cotard syndrome is a rare condition whose main feature is a nihilistic delusion ranging from the denial of body parts to that of the existence of one's own life or even the entire universe. Objectives: The aim of this article is to review the nosological significance of Cotard syndrome and to explore the disorder among patients with dementia. Methods: Medline and Google Scholar searches were conducted for relevant articles, chapters and books published before 2018. Search terms used included Cotard delusion, Cotard syndrome and dementia, nihilistic delusion. Publications found through this indexed search were reviewed for further relevant references. Results and conclusion: In this narrative review we emphasise the fact that cases of Cotard syndrome involving patients with dementia are reported quite infrequently. Published studies are limited to very short series or isolated cases. Clinicians are obliged to treat the disorder. They should be alert to the potential high risk inherent in this condition. Keypoints Cotard syndrome is a rare condition characterised by nihilistic delusions that may range from negation of existence of parts of the body to delusion of being dead. The prevalence and incidence of this rare syndrome are not known. Since Cotard's syndrome is conceptualised as part of an underlying disorder, several psychiatric and somatic diseases have been associated with the syndrome. The syndrome may occur in patients suffering from dementia.
- Published
- 2019
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- View/download PDF
36. Links Between Painting and Neurology: The Example of Dementia.
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Cipriani G, Cipriani L, Danti S, Picchi L, and Di Fiorino M
- Subjects
- Cognition, Emotions, Humans, Art, Creativity, Dementia classification, Dementia psychology, Neurology
- Abstract
Art is a system of human communication arising from symbolic cognition, conveying ideas, experiences, and feelings. The goal of this review is to describe the link between painting and dementia. Individuals with neurodegenerative diseases inevitably experience cognitive dysfunction that has the potential to limit and impair the artist's ability to realize their creative and expressive intentions through painting. The strategy to advance our understanding of the neural bases for art is to map locations and nature of neural damage to changes onto artistic production.
- Published
- 2019
- Full Text
- View/download PDF
37. Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways.
- Author
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Miner K, Labitzke K, Liu B, Wang P, Henckels K, Gaida K, Elliott R, Chen JJ, Liu L, Leith A, Trueblood E, Hensley K, Xia XZ, Homann O, Bennett B, Fiorino M, Whoriskey J, Yu G, Escobar S, Wong M, Born TL, Budelsky A, Comeau M, Smith D, Phillips J, Johnston JA, McGivern JG, Weikl K, Powers D, Kunzelmann K, Mohn D, Hochheimer A, and Sullivan JK
- Abstract
There is an unmet need in severe asthma where approximately 40% of patients exhibit poor β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations. Antagonists of the Ca
2+ -activated Cl- channel, TMEM16A, offers a new mechanism to bronchodilate airways and block the multiple contractiles operating in severe disease. To identify TMEM16A antagonists we screened a library of ∼580,000 compounds. The anthelmintics niclosamide, nitazoxanide, and related compounds were identified as potent TMEM16A antagonists that blocked airway smooth muscle depolarization and contraction. To evaluate whether TMEM16A antagonists resist use- and inflammatory-desensitization pathways limiting β-agonist action, we tested their efficacy under harsh conditions using maximally contracted airways or airways pretreated with a cytokine cocktail. Stunningly, TMEM16A antagonists fully bronchodilated airways, while the β-agonist isoproterenol showed only partial effects. Thus, antagonists of TMEM16A and repositioning of niclosamide and nitazoxanide represent an important additional treatment for patients with severe asthma and COPD that is poorly controlled with existing therapies. It is of note that drug repurposing has also attracted wide interest in niclosamide and nitazoxanide as a new treatment for cancer and infectious disease. For the first time we identify TMEM16A as a molecular target for these drugs and thus provide fresh insights into their mechanism for the treatment of these disorders in addition to respiratory disease.- Published
- 2019
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- View/download PDF
38. TRIAMF: A New Method for Delivery of Cas9 Ribonucleoprotein Complex to Human Hematopoietic Stem Cells.
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Yen J, Fiorino M, Liu Y, Paula S, Clarkson S, Quinn L, Tschantz WR, Klock H, Guo N, Russ C, Yu VWC, Mickanin C, Stevenson SC, Lee C, and Yang Y
- Subjects
- Animals, CRISPR-Associated Protein 9 genetics, CRISPR-Cas Systems genetics, Cells, Cultured, Electroporation methods, Female, Fetal Hemoglobin metabolism, Filtration economics, Filtration instrumentation, Genetic Therapy economics, Genetic Therapy instrumentation, Genetic Therapy methods, Hematopoietic Stem Cells metabolism, Hemoglobinopathies genetics, Hemoglobinopathies therapy, Humans, Membranes, Artificial, Mice, Models, Animal, RNA, Guide, CRISPR-Cas Systems genetics, Transplantation, Autologous, Fetal Hemoglobin genetics, Filtration methods, Gene Editing methods, Hematopoietic Stem Cell Transplantation, Ribonucleoproteins genetics
- Abstract
CRISPR/Cas9 mediated gene editing of patient-derived hematopoietic stem and progenitor cells (HSPCs) ex vivo followed by autologous transplantation of the edited HSPCs back to the patient can provide a potential cure for monogenic blood disorders such as β-hemoglobinopathies. One challenge for this strategy is efficient delivery of the ribonucleoprotein (RNP) complex, consisting of purified Cas9 protein and guide RNA, into HSPCs. Because β-hemoglobinopathies are most prevalent in developing countries, it is desirable to have a reliable, efficient, easy-to-use and cost effective delivery method. With this goal in mind, we developed TRansmembrane Internalization Assisted by Membrane Filtration (TRIAMF), a new method to quickly and effectively deliver RNPs into HSPCs by passing a RNP and cell mixture through a filter membrane. We achieved robust gene editing in HSPCs using TRIAMF and demonstrated that the multilineage colony forming capacities and the competence for engraftment in immunocompromised mice of HSPCs were preserved post TRIAMF treatment. TRIAMF is a custom designed system using inexpensive components and has the capacity to process HSPCs at clinical scale.
- Published
- 2018
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- View/download PDF
39. A Contagious Disorder: Folie à Deux and Dementia.
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Cipriani G, Abdel-Gawad N, Danti S, and Di Fiorino M
- Subjects
- Delusions psychology, Humans, Interpersonal Relations, Risk Factors, Dementia psychology, Shared Paranoid Disorder psychology, Social Isolation
- Abstract
Background: Folie à deux is a clinical condition that was first described in 19th century. It is a psychotic disorder in which two closely associated individuals share a similar delusional system., Objectives: The aim of this article is to review the nosological significance of folie à deux and to explore the disorder among patients with dementia., Methods: Medline and Google Scholar searches were conducted for relevant articles, chapters, and books published before 2017. Search terms used included dementia, folie à deux, induced delusional disorder, neurocognitive disorders, shared psychotic disorder. Publications found through this indexed search were reviewed for further relevant references., Results and Conclusion: Cases of Folie à deux involving patients with dementia are reported quite infrequently. Most of the studies on the topic consist in case reports. Clinicians are obliged to treat the disorder. They should be alert to the potential high risk inherent this psychotic syndrome.
- Published
- 2018
- Full Text
- View/download PDF
40. Art is long, life is short. Francisco José de Goya y Lucientes (1746-1828), the suffering artist.
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Cipriani G, Cipriani L, Picchi L, and Di Fiorino M
- Subjects
- Cinchona adverse effects, Cogan Syndrome history, Famous Persons, History, 19th Century, Humans, Lead Poisoning history, Malaria history, Psychotic Disorders history, Spain, Syphilis history, Uveomeningoencephalitic Syndrome history, Art, Deafness history, Paintings, Stroke history
- Abstract
Francisco José de Goya y Lucientes is one of the major figures of European art. From royal portraits to bizarre, grotesque illustrations, his legacy demonstrates a tortured genius, generating some of the most compelling art ever produced. His story is also the story of Spain during one of the most tumultuous passages of its history. In the winter of 1792-93, Goya experienced a mysterious illness resulting in lifelong deafness. After that, his work became more negative, with thick, bold strokes of dark colour. Scholars have suggested various diagnoses on the basis of Master's symptoms, but the exact nature of the illness has never been identified., (Copyright © 2018. Published by Elsevier Ltd.)
- Published
- 2018
- Full Text
- View/download PDF
41. Uncommon and/or bizarre features of dementia. Part II.
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Cipriani G, Danti S, Nuti A, Lucetti C, and Di Fiorino M
- Subjects
- Delusions classification, Delusions diagnosis, Female, Humans, Male, Delusions etiology, Dementia complications
- Abstract
In the past decades, clinicians have recognized that dementia may appear as atypical or variant syndromes, as well as the typical form. This study aimed at describing uncommon or bizarre symptoms/syndromes observed in patients suffering from dementia. Medline and Google scholar searches were conducted for relevant articles, chapters, and books published before 2017. Search terms used included delusional jealousy, delusion of pregnancy, dementia, erotomania, folie à deux, and lycanthropy. Publications found through this indexed search were reviewed for further relevant references. The uncommon symptoms/syndromes were described as case reports and there were no systematic investigations.
- Published
- 2018
- Full Text
- View/download PDF
42. Complex Vascular Ring Diagnosed on Cardiovascular MR in a 3-Day-Old Infant.
- Author
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Burt JR, Valente M, Agha A, Beavers K, Limback J, Fiorino M, Vicenti R, Tissavirasingham F, Butt K, and Crofton AR
- Abstract
Prenatal ultrasonography in the early third trimester showed an unusual branching pattern of the right aortic arch. Echocardiography performed 4 h after birth showed the right aortic arch with mirror-image branching, patent ductus arteriosus, and patent foramen ovale. Because the location of the ductus arteriosus was unclear on echocardiography, cardiovascular magnetic resonance imaging was performed 3 days after birth. Advanced techniques including contrast-enhanced time-resolved magnetic resonance angiography and 3D time-of-flight magnetic resonance angiography allowed accurate diagnosis of a vascular ring comprising ascending and descending aorta, right aortic arch with mirror-image branching, and diverticulum of Kommerell giving rise to a left ligamentum arteriosum. The infant had hiccups, but no other symptoms. The esophagram was negative for obstruction. The infant was closely monitored; however, she developed esophageal obstruction at 7 months of age because of the vascular ring. She underwent lysis of the left ligamentum arteriosum followed by aortopexy for relief of esophageal obstruction. This report shows the utility of neonatal cardiovascular magnetic resonance imaging to evaluate complex congenital aortic arch anomalies., Competing Interests: Conflict of Interest: The authors have no conflict of interest to declare.
- Published
- 2018
- Full Text
- View/download PDF
43. Aging With Down Syndrome: The Dual Diagnosis: Alzheimer's Disease and Down Syndrome.
- Author
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Cipriani G, Danti S, Carlesi C, and Di Fiorino M
- Subjects
- Humans, Aging psychology, Alzheimer Disease etiology, Down Syndrome complications, Early Diagnosis
- Abstract
Background: People with Down syndrome (DS) enjoy a longer life expectancy now than they ever have before and are therefore at greater risk of developing conditions associated with aging, including dementia., Objectives: To explore the phenomenon of dementia in DS., Methods: Medline and Google Scholar searches were conducted for relevant articles, chapters, and books published until 2017. Search terms included Alzheimer's disease, cognitive impairment, dementia, DS, and trisomy 21. Publications found through this indexed search were reviewed for further references., Results and Conclusions: Virtually, all subject aged 35 to 40 show key neuropathologic changes characteristic of Alzheimer's disease, but only a part of them show clinical signs of dementia, usually around the age of 50 years. Early signs of dementia in people with DS may be different from those experienced by the general population. Failure to recognize this can delay diagnosis and subsequent interventions.
- Published
- 2018
- Full Text
- View/download PDF
44. ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation.
- Author
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Rostami K, Marsh MN, Johnson MW, Mohaghegh H, Heal C, Holmes G, Ensari A, Aldulaimi D, Bancel B, Bassotti G, Bateman A, Becheanu G, Bozzola A, Carroccio A, Catassi C, Ciacci C, Ciobanu A, Danciu M, Derakhshan MH, Elli L, Ferrero S, Fiorentino M, Fiorino M, Ganji A, Ghaffarzadehgan K, Going JJ, Ishaq S, Mandolesi A, Mathews S, Maxim R, Mulder CJ, Neefjes-Borst A, Robert M, Russo I, Rostami-Nejad M, Sidoni A, Sotoudeh M, Villanacci V, Volta U, Zali MR, and Srivastava A
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Biopsy, Case-Control Studies, Celiac Disease diagnosis, Child, Child, Preschool, Diagnosis, Differential, Female, Humans, Infant, Infant, Newborn, Lymphocyte Count, Male, Middle Aged, Prognosis, ROC Curve, Celiac Disease immunology, Intestinal Mucosa immunology, Lymphocytes immunology
- Abstract
Objectives: Counting intraepithelial lymphocytes (IEL) is central to the histological diagnosis of coeliac disease (CD), but no definitive 'normal' IEL range has ever been published. In this multicentre study, receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off between normal and CD (Marsh III lesion) duodenal mucosa, based on IEL counts on >400 mucosal biopsy specimens., Design: The study was designed at the International Meeting on Digestive Pathology, Bucharest 2015. Investigators from 19 centres, eight countries of three continents, recruited 198 patients with Marsh III histology and 203 controls and used one agreed protocol to count IEL/100 enterocytes in well-oriented duodenal biopsies. Demographic and serological data were also collected., Results: The mean ages of CD and control groups were 45.5 (neonate to 82) and 38.3 (2-88) years. Mean IEL count was 54±18/100 enterocytes in CD and 13±8 in normal controls (p=0.0001). ROC analysis indicated an optimal cut-off point of 25 IEL/100 enterocytes, with 99% sensitivity, 92% specificity and 99.5% area under the curve. Other cut-offs between 20 and 40 IEL were less discriminatory. Additionally, there was a sufficiently high number of biopsies to explore IEL counts across the subclassification of the Marsh III lesion., Conclusion: Our ROC curve analyses demonstrate that for Marsh III lesions, a cut-off of 25 IEL/100 enterocytes optimises discrimination between normal control and CD biopsies. No differences in IEL counts were found between Marsh III a, b and c lesions. There was an indication of a continuously graded dose-response by IEL to environmental (gluten) antigenic influence., Competing Interests: Competing interests: None declared., (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
- Published
- 2017
- Full Text
- View/download PDF
45. Armed and Aging: Dementia and Firearms Do Not Mix !
- Author
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Cipriani G, Danti S, Carlesi C, and Di Fiorino M
- Subjects
- Aged, Aged, 80 and over, Family Characteristics, Female, Firearms ethics, Humans, Male, Wounds, Gunshot prevention & control, Dementia complications, Dementia psychology, Firearms legislation & jurisprudence
- Abstract
The possibility that persons with dementia possess firearms is cause for concern, but only a limited number of research studies have been conducted on such a topic, usually in the form of case reports. Reducing the occurrence of the firearm-related violence requires effectively identifying dangerous individuals and keeping firearms out of their hands. The health care professionals, i.e. the social workers and the physicians, need to work together and to produce a suitable evaluation of patients with dementia to prevent firearm-related injuries and serious and irreparable damage to persons.
- Published
- 2017
- Full Text
- View/download PDF
46. Old and dangerous: Prison and dementia.
- Author
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Cipriani G, Danti S, Carlesi C, and Di Fiorino M
- Subjects
- Aged, Humans, Mental Competency, Population Dynamics, Dementia psychology, Prisoners psychology
- Abstract
Older prisoners are the fastest growing group of prisoners in many countries. The purpose of this study is to explore the phenomenon of detention of persons suffering from dementia. Medline searches were conducted for relevant articles, chapters and books published until August 2016. Search terms included dementia, elderly, prison and criminal. Publications found through this indexed search were reviewed for further relevant references. As results, there is a lack of data about elderly with dementia in prisons. Given the rise in the average age, it is reasonable to hypothesize that the number of older prisoners is growing. Moreover, some elderly are imprisoned with a concomitant cognitive impairment or psychiatric disorder while others will develop such diseases once incarcerated. At the present time, legal and social systems seem unprepared to handle the phenomenon of dementia in prison. As proposal, health assessments for older first time offenders should become a practice inside the correctional facilities and include an evaluation for specific health issues, such as psychiatric comorbidity and cognitive impairment., (Copyright © 2017 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
47. Bipolar Disorder and Cognitive Dysfunction: A Complex Link.
- Author
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Cipriani G, Danti S, Carlesi C, Cammisuli DM, and Di Fiorino M
- Subjects
- Humans, Bipolar Disorder complications, Cognitive Dysfunction etiology, Dementia etiology
- Abstract
The aim of this article was to describe the current evidence regarding phenomenon of cognitive functioning and dementia in bipolar disorder (BD). Cochrane Library and PubMed searches were conducted for relevant articles, chapters, and books published before 2016. Search terms used included "bipolar disorder," "cognitive dysfunction," and "dementia." At the end of the selection process, 159 studies were included in our qualitative synthesis. As result, cognitive impairments in BD have been previously considered as infrequent and limited to the affective episodes. Nowadays, there is evidence of stable and lasting cognitive dysfunctions in all phases of BD, including remission phase, particularly in the following domains: attention, memory, and executive functions. The cause of cognitive impairment in BD raises the question if it subtends a neurodevelopmental or a neurodegenerative process. Impaired cognitive functioning associated with BD may contribute significantly to functional disability, in addition to the distorted affective component usually emphasized.
- Published
- 2017
- Full Text
- View/download PDF
48. Personality and destiny. Francesco Borromini: portrait of a tormented soul.
- Author
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Cipriani G, Cipriani L, and Di Fiorino M
- Subjects
- Depression psychology, History, 17th Century, Humans, Italy, Suicide psychology, Architecture history, Depression history, Personality, Suicide history
- Abstract
Francesco Borromini, one of the great geniuses of Baroque architecture, was tormented and solitary, and was increasingly frustrated by the fame and success of his rival, Gian Lorenzo Bernini. Borromini was an unhappy man, constantly dogged by disaster, quarrelling even with his best patrons and closest friends. In the culmination of one of the fits of depression that overcame the architect more and more frequently as his life progressed, Borromini literally fell on his own sword; he lingered in excruciating pain for 24 hours before dying. Largely forgotten, his architecture has again been recognized since the twentieth century as the creation of genius. We try to describe the personality and suicide of this pessimist giant of architecture.
- Published
- 2017
- Full Text
- View/download PDF
49. Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation.
- Author
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Maxwell JR, Zhang Y, Brown WA, Smith CL, Byrne FR, Fiorino M, Stevens E, Bigler J, Davis JA, Rottman JB, Budelsky AL, Symons A, and Towne JE
- Subjects
- ATP Binding Cassette Transporter, Subfamily B deficiency, Animals, Colitis drug therapy, Colitis etiology, Colitis microbiology, Disease Models, Animal, Disease Progression, Epithelium physiopathology, Female, Forkhead Transcription Factors analysis, Gene Expression Regulation immunology, Helicobacter Infections complications, Helicobacter Infections immunology, Immunization, Passive, Immunoglobulin G therapeutic use, Interleukin-12 Subunit p40 antagonists & inhibitors, Interleukin-17 immunology, Interleukin-23 immunology, Interleukin-23 Subunit p19 antagonists & inhibitors, Interleukin-23 Subunit p19 immunology, Intestinal Mucosa physiopathology, Mice, Mice, Knockout, Permeability, Receptors, Interleukin-17 antagonists & inhibitors, Receptors, Interleukin-17 immunology, T-Lymphocyte Subsets immunology, T-Lymphocytes, Regulatory immunology, Transcriptome, Colitis immunology, Interleukin-17 physiology, Interleukin-23 physiology, Receptors, Interleukin-17 physiology
- Abstract
Interleukin-23 (IL-23) and IL-17 are cytokines currently being targeted in clinical trials. Although inhibition of both of these cytokines is effective for treating psoriasis, IL-12 and IL-23 p40 inhibition attenuates Crohn's disease, whereas IL-17A or IL-17 receptor A (IL-17RA) inhibition exacerbates Crohn's disease. This dichotomy between IL-23 and IL-17 was effectively modeled in the multidrug resistance-1a-ablated (Abcb1a(-/-)) mouse model of colitis. IL-23 inhibition attenuated disease by decreasing colonic inflammation while enhancing regulatory T (Treg) cell accumulation. Exacerbation of colitis by IL-17A or IL-17RA inhibition was associated with severe weakening of the intestinal epithelial barrier, culminating in increased colonic inflammation and accelerated mortality. These data show that IL-17A acts on intestinal epithelium to promote barrier function and provide insight into mechanisms underlying exacerbation of Crohn's disease when IL-17A or IL-17RA is inhibited., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
50. Delusion of pregnancy: an unusual symptom in the context of dementia.
- Author
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Cipriani G and Di Fiorino M
- Subjects
- Humans, Delusions etiology, Dementia complications
- Abstract
Background: Delusions can complicate practically all brain disorders. They may be dramatic and bizarre. An example is the so-called delusion of pregnancy., Objective: To identify the characteristic of a psychotic symptom, the phenomenon of delusion of pregnancy, in the context of dementia., Method: MEDLINE and Google Scholar searches were conducted for relevant articles, chapters, and books published before 2014. Search terms used included delusion of pregnancy, uncommon presentation, behavioral and psychological symptoms, dementia, Alzheimer's disease, and frontotemporal dementia (FTD). Publications found through this indexed search were reviewed for further relevant references. We included case reports that highlight the relationship and overlap between dementia presenting as schizophrenia-like psychosis and schizophrenia., Results: Literature on delusion of pregnancy in the course of dementia consists mostly of case reports and small samples of patients., Conclusion: Psychotic phenomena such as delusion of pregnancy may be a feature in some cases of dementia. If this bizarre features of dementia appears as early presentation of FTD whose usual onset is in the presenium, it may be mistaken for schizophrenia., (© The Author(s) 2014.)
- Published
- 2015
- Full Text
- View/download PDF
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