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Your search keyword '"Fernandez-Teruel, Alberto"' showing total 26 results
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26 results on '"Fernandez-Teruel, Alberto"'

13. Prevalence and influence of cys407* Grm2 mutation in Hannover-derived Wistar rats: mGlu2 receptor loss links to alcohol intake, risk taking and emotional behaviour

Author

Wood, Christian M., Nicolas, Celine S., Choi, Sun-Lim, Roman, Erika, Nylander, Ingrid, Fernandez-Teruel, Alberto, Kiianmaa, Kalervo, Bienkowski, Przemyslaw, de Jong, Trynke R., Colombo, Giancarlo, Chastagnier, Denis, Wafford, Keith A., Collingridge, Graham L., Wildt, Sheryl J., Conway-Campbell, Becky L., Robinson, Emma S.J., and Lodge, David

Published
2017
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14. Neonatal handling enduringly decreases anxiety and stress responses and reduces hippocampus and amygdala volume in a genetic model of differential anxiety: Behavioral-volumetric associations in the Roman rat strains

Author

Río-Álamos, Cristóbal, Oliveras, Ignasi, Piludu, Maria Antonietta, Gerbolés, Cristina, Cañete, Toni, Blázquez, Gloria, Lope-Piedrafita, Silvia, Martínez-Membrives, Esther, Torrubia, Rafael, Tobeña, Adolf, and Fernández-Teruel, Alberto

Published
2017
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18. Acute relaxation response induced by tibetan singing bowl sounds: a randomized controlled trial

Author

Rio Alamos, Cristobal, Montefusco Siegmund, Rodrigo, Cañete, Toni, Sotomayor, Joaquín, Fernandez Teruel, Alberto, Rio Alamos, Cristobal, Montefusco Siegmund, Rodrigo, Cañete, Toni, Sotomayor, Joaquín, and Fernandez Teruel, Alberto

Abstract

The prevalence of anxiety has increased dramatically due to COVID-19, so effective preventive interventions are welcome. The main objective of our study was to compare the acute relaxation response (RR) induced by Tibetan singing bowl (TSB) sound-based treatment against progressive muscle relaxation (PMR) and a control waiting list group (CWL) in a single treatment session in an adult nonclinical anxious population. In this cross-sectional randomized control trial, 50 participants selected based on high state anxiety were randomly assigned to one of the experimental groups. Pre/post self-reported anxiety, electroencephalographic activity (EEG), and heart rate variability (HRV) were recorded at baseline (T1), minute 15 (T2), minute 30 (T3), and minute 45 (T4). The TSB group showed significant reductions in alpha power (from T2 to T4) and increased HRV (from T3 to T4) compared with the PMR and CWL groups. Moreover, TSB and PMR both showed significant reductions in self-reported anxiety compared with CWL, with this effect being more evident in the TSB group. We concluded that a single session of TSB treatment was able to induce a more evident psychological/physiological relaxation response compared with PMR and CWL. TSB could be a relevant acute intervention in stressful situations or crisis intervention and while waiting for conventional interventions.

Published
2023

19. A maturational shift in the frontal cortex synaptic transcriptional landscape underlies schizophrenia-relevant behavioural traits:A congenital rat model

Author

Sønderstrup, Marie, Batiuk, Mykhailo Y., Mantas, Panagiotis, Tapias-Espinosa, Carles, Oliveras, Ignasi, Cañete, Toni, Sampedro-Viana, Daniel, Brudek, Tomasz, Rydbirk, Rasmus, Khodosevich, Konstantin, Fernandez-Teruel, Alberto, Elfving, Betina, Aznar, Susana, Sønderstrup, Marie, Batiuk, Mykhailo Y., Mantas, Panagiotis, Tapias-Espinosa, Carles, Oliveras, Ignasi, Cañete, Toni, Sampedro-Viana, Daniel, Brudek, Tomasz, Rydbirk, Rasmus, Khodosevich, Konstantin, Fernandez-Teruel, Alberto, Elfving, Betina, and Aznar, Susana

Abstract

Disruption of brain development early in life may underlie the neurobiology behind schizophrenia. We have reported more immature synaptic spines in the frontal cortex (FC) of adult Roman High-Avoidance (RHA-I) rats, a behavioural model displaying schizophrenia-like traits. Here, we performed a whole transcriptome analysis in the FC of 4 months old male RHA-I (n=8) and its counterpart, the Roman Low-Avoidance (RLA-I) (n=8). We identified 203 significant genes with overrepresentation of genes involved in synaptic function. Next, we performed a gene set enrichment analysis (GSEA) for genes co-expressed during neurodevelopment. Gene networks were obtained by weighted gene co-expression network analysis (WGCNA) of a transcriptomic dataset containing human FC during lifespan (n=269). Out of thirty-one functional gene networks, six were significantly enriched in the RHA-I. These were differentially regulated during infancy and enriched in biological ontologies related to myelination, synaptic function, and immune response. We validated differential gene expression in a new cohort of adolescent (<=2 months old) and young-adult (>=3 months old) RHA-I and RLA-I rats. The results confirmed overexpression of Gsn, Nt5cd1, Ppp1r1b, and Slc9a3r1 in young-adult RHA-I, while Cables1, a regulator of Cdk5 phosphorylation in actin regulation and involved in synaptic plasticity and maturation, was significantly downregulated in adolescent RHA-I. This age-related expression change was also observed for presynaptic components Snap25 and Snap29. Our results show a different maturational expression profile of synaptic components in the RHA-I strain, supporting a shift in FC maturation underlying schizophrenia-like behavioural traits and adding construct validity to this strain as a neurodevelopmental model.

Published
2023

20. Fine mapping of bone structure and strength QTLs in heterogeneous stock rat

Author

Alam, Imranul, Koller, Daniel L., Cañete, Toni, Blázquez, Gloria, Mont-Cardona, Carme, López-Aumatell, Regina, Martínez-Membrives, Esther, Díaz-Morán, Sira, Tobeña, Adolf, Fernández-Teruel, Alberto, Stridh, Pernilla, Diez, Margarita, Olsson, Tomas, Johannesson, Martina, Baud, Amelie, Econs, Michael J., and Foroud, Tatiana

Published
2015
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25. A Scientometric Approach to Review the Role of the Medial Preoptic Area (MPOA) in Parental Behavior.

Author

Carollo, Alessandro, Balagtas, Jan Paolo Macapinlac, Neoh, Michelle Jin-Yee, Esposito, Gianluca, and Fernandez-Teruel, Alberto

Subjects
PREOPTIC area, REWARD (Psychology), SCIENTIFIC literature, POSTPARTUM depression, HUMAN behavior
Abstract

Research investigating the neural substrates underpinning parental behaviour has recently gained momentum. Particularly, the hypothalamic medial preoptic area (MPOA) has been identified as a crucial region for parenting. The current study conducted a scientometric analysis of publications from 1 January 1972 to 19 January 2021 using CiteSpace software to determine trends in the scientific literature exploring the relationship between MPOA and parental behaviour. In total, 677 scientific papers were analysed, producing a network of 1509 nodes and 5498 links. Four major clusters were identified: "C-Fos Expression", "Lactating Rat", "Medial Preoptic Area Interaction" and "Parental Behavior". Their content suggests an initial trend in which the properties of the MPOA in response to parental behavior were studied, followed by a growing attention towards the presence of a brain network, including the reward circuits, regulating such behavior. Furthermore, while attention was initially directed uniquely to maternal behavior, it has recently been extended to the understanding of paternal behaviors as well. Finally, although the majority of the studies were conducted on rodents, recent publications broaden the implications of previous documents to human parental behavior, giving insight into the mechanisms underlying postpartum depression. Potential directions in future works were also discussed. [ABSTRACT FROM AUTHOR]

Published
2021
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26. Application of a Clinical Workflow May Lead to Increased Diagnostic Precision in Hereditary Spastic Paraplegias and Cerebellar Ataxias: A Single Center Experience.

Author

Riso, Vittorio, Rossi, Salvatore, Nicoletti, Tommaso F., Tessa, Alessandra, Travaglini, Lorena, Zanni, Ginevra, Aiello, Chiara, Perna, Alessia, Barghigiani, Melissa, Pomponi, Maria Grazia, Santorelli, Filippo M., Silvestri, Gabriella, and Fernandez-Teruel, Alberto

Subjects
FAMILIAL spastic paraplegia, MEDICAL personnel, GENES, WORKFLOW, PATIENT selection, DIAGNOSIS
Abstract

The molecular characterization of Hereditary Spastic Paraplegias (HSP) and inherited cerebellar ataxias (CA) is challenged by their clinical and molecular heterogeneity. The recent application of Next Generation Sequencing (NGS) technologies is increasing the diagnostic rate, which can be influenced by patients' selection. To assess if a clinical diagnosis of CA/HSP received in a third-level reference center might impact the molecular diagnostic yield, we retrospectively evaluated the molecular diagnostic rate reached in our center on 192 unrelated families (90 HSP and 102 CA) (i) before NGS and (ii) with the use of NGS gene panels. Overall, 46.3% of families received a genetic diagnosis by first-tier individual gene screening: 43.3% HSP and 50% spinocerebellar ataxias (SCA). The diagnostic rate was 56.7% in AD-HSP, 55.5% in AR-HSP, and 21.2% in sporadic HSP. On the other hand, 75% AD-, 52% AR- and 33% sporadic CA were diagnosed. So far, 32 patients (24 CA and 8 HSP) were further assessed by NGS gene panels, and 34.4% were diagnosed, including 29.2% CA and 50% HSP patients. Eleven novel gene variants classified as (likely) pathogenic were identified. Our results support the role of experienced clinicians in the diagnostic assessment and the clinical research of CA and HSP even in the next generation era. [ABSTRACT FROM AUTHOR]

Published
2021
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