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2. Parent-Reported Clinical Utility of Pediatric Genomic Sequencing.

Author

Smith, Hadley Stevens, Ferket, Bart S, Gelb, Bruce D, Hindorff, Lucia, Ferar, Kathleen D, Norton, Mary E, Sahin-Hodoglugil, Nuriye, Slavotinek, Anne, Lich, Kristen Hasmiller, Berg, Jonathan S, and Russell, Heidi V

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Pediatric, Behavioral and Social Science, Clinical Research, Health Services, Good Health and Well Being, Humans, Child, Parents, Surveys and Questionnaires, Life Style, Genomics, Medical and Health Sciences, Psychology and Cognitive Sciences, Pediatrics, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

Background and objectivesGenomic sequencing (GS) is increasingly used for diagnostic evaluation, yet follow-up care is not well understood. We assessed clinicians' recommendations after GS, parent-reported follow-up, and actions parents initiated in response to learning their child's GS results.MethodsWe surveyed parents of children who received GS through the Clinical Sequencing Evidence Generating Research consortium ∼5 to 7 months after return of results. We compared the proportion of parents who reported discussing their child's result with a clinician, clinicians' recommendations, and parents' follow-up actions by GS result type using χ2 tests.ResultsA total of 1188 respondents completed survey measures on recommended medical actions (n = 1187) and/or parent-initiated actions (n = 913). Most parents who completed recommended medical actions questions (n = 833, 70.3%) reported having discussed their child's GS results with clinicians. Clinicians made recommendations to change current care for patients with positive GS results (n = 79, 39.1%) more frequently than for those with inconclusive (n = 31, 12.4%) or negative results (n = 44, 11.9%; P < .001). Many parents discussed (n = 152 completed, n = 135 planned) implications of GS results for future pregnancies with a clinician. Aside from clinical recommendations, 13.0% (n = 119) of parents initiated changes to their child's health or lifestyle.ConclusionsIn diverse pediatric clinical contexts, GS results can lead to recommendations for follow-up care, but they likely do not prompt large increases in the quantity of care received.

Published
2023

3. Employing effective recruitment and retention strategies to engage a diverse pediatric population in genomics research

Author

Ramos, Michelle A., Bonini, Katherine E., Scarimbolo, Laura, Kelly, Nicole R., Insel, Beverly, Suckiel, Sabrina A., Brown, Kaitlyn, Di Biase, Miranda, Gallagher, Katie M., Lopez, Jessenia, Aguiñiga, Karla López, Marathe, Priya N., Maria, Estefany, Odgis, Jacqueline A., Rodriguez, Jessica E., Rodriguez, Michelle A., Ruiz, Nairovylex, Sebastin, Monisha, Yelton, Nicole M., Cunningham-Rundles, Charlotte, Gertner, Melvin, Laguerre, Irma, McDonald, Thomas V., McGoldrick, Patricia E., Robinson, Mimsie, Rubinstein, Arye, Shulman, Lisa H., Williams, Trinisha, Wolf, Steven M., Yozawitz, Elissa G., Zinberg, Randi E., Abul-Husn, Noura S., Bauman, Laurie J., Diaz, George A., Ferket, Bart S., Greally, John M., Jobanputra, Vaidehi, Gelb, Bruce D., Kenny, Eimear E., Wasserstein, Melissa P., and Horowitz, Carol R.

Published
2024
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4. Longitudinal Plasma Metabolome Patterns and Relation to Kidney Function and Proteinuria in Pediatric CKD

Author

Lee, Arthur M., Xu, Yunwen, Hu, Jian, Xiao, Rui, Hooper, Stephen R., Hartung, Erum A., Coresh, Josef, Rhee, Eugene P., Vasan, Ramachandran S., Kimmel, Paul L., Warady, Bradley A., Furth, Susan L., Denburg, Michelle R., Abraham, Alison, Anderson, Amanda, Ballard, Shawn, Bonventre, Joseph, Clish, Clary, Collins, Heather, Coca, Steven, Coresh, Josef, Deo, Rajat, Denburg, Michelle, Dubin, Ruth, Feldman, Harold I., Ferket, Bart S., Foster, Meredith, Furth, Susan, Ganz, Peter, Gossett, Daniel, Grams, Morgan, Greenberg, Jason, Gutiérrez, Orlando M., Hostetter, Tom, Inker, Lesley A., Ix, Joachim, Kimmel, Paul L., Klein, Jon, Levey, Andrew S., Massaro, Joseph, McMahon, Gearoid, Mifflin, Theodore, Nadkarni, Girish N., Parikh, Chirag, Ramachandran, Vasan S., Rebholz, Casey, Rhee, Eugene, Rovin, Brad, Sarnak, Mark, Sabbisetti, Venkata, Schelling, Jeffrey, Seegmiller, Jesse, Shlipak, Michael G., Shou, Haochang, Tin, Adriene, Waikar, Sushrut, Warady, Bradley, Whitehead, Krista, and Xie, Dawei

Published
2024
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5. US private payers’ perspectives on insurance coverage for genome sequencing versus exome sequencing: A study by the Clinical Sequencing Evidence-Generating Research Consortium (CSER)

Author

Phillips, Kathryn A, Trosman, Julia R, Douglas, Michael P, Gelb, Bruce D, Ferket, Bart S, Hindorff, Lucia A, Slavotinek, Anne M, Berg, Jonathan S, Russell, Heidi V, Devine, Beth, Greve, Veronica, and Smith, Hadley Stevens

Subjects
Biological Sciences, Genetics, Human Genome, Clinical Research, Good Health and Well Being, Base Sequence, Chromosome Mapping, Exome, Humans, Insurance Coverage, Exome Sequencing, Clinical Sciences, Genetics & Heredity
Abstract

PurposeThere is limited payer coverage for genome sequencing (GS) relative to exome sequencing (ES) in the U.S. Our objective was to assess payers' considerations for coverage of GS versus coverage of ES and requirements payers have for coverage of GS. The study was conducted by the NIH-funded Clinical Sequencing Evidence-Generating Research Consortium (CSER).MethodsWe conducted semi-structured interviews with representatives of private payer organizations (payers, N = 12) on considerations and evidentiary and other needs for coverage of GS and ES. Data were analyzed using thematic analysis.ResultsWe described four categories of findings and solutions: demonstrated merits of GS versus ES, enhanced methods for evidence generation, consistent laboratory processes/sequencing methods, and enhanced implementation/care delivery. Payers see advantages to GS vs. ES and are open to broader GS coverage but need more proof of these advantages to consider them in coverage decision-making. Next steps include establishing evidence of benefits in specific clinical scenarios, developing quality standards, ensuring transparency of laboratory methods, developing clinical centers of excellence, and incorporating the role of genetic professionals.ConclusionBy comparing coverage considerations for GS and ES, we identified a path forward for coverage of GS. Future research should explicitly address payers' conditions for coverage.

Published
2022

7. The TeleKidSeq pilot study: incorporating telehealth into clinical care of children from diverse backgrounds undergoing whole genome sequencing

Author

Sebastin, Monisha, Odgis, Jacqueline A., Suckiel, Sabrina A., Bonini, Katherine E., Di Biase, Miranda, Brown, Kaitlyn, Marathe, Priya, Kelly, Nicole R., Ramos, Michelle A., Rodriguez, Jessica E., Aguiñiga, Karla López, Lopez, Jessenia, Maria, Estefany, Rodriguez, Michelle A., Yelton, Nicole M., Cunningham-Rundles, Charlotte, Gallagher, Katie, McDonald, Thomas V., McGoldrick, Patricia E., Robinson, Mimsie, Rubinstein, Arye, Shulman, Lisa H., Wolf, Steven M., Yozawitz, Elissa, Zinberg, Randi E., Abul-Husn, Noura S., Bauman, Laurie J., Diaz, George A., Ferket, Bart S., Greally, John M., Jobanputra, Vaidehi, Gelb, Bruce D., Horowitz, Carol R., Kenny, Eimear E., and Wasserstein, Melissa P.

Published
2023
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8. Physician services and costs after disclosure of diagnostic sequencing results in the NYCKidSeq program

Author

Berkalieva, Asem, Kelly, Nicole R., Fisher, Ashley, Hohmann, Samuel F., Sebastin, Monisha, Di Biase, Miranda, Bonini, Katherine E., Marathe, Priya, Odgis, Jacqueline A., Suckiel, Sabrina A., Ramos, Michelle A., Rhodes, Rosamond, Abul-Husn, Noura S., Greally, John M., Horowitz, Carol R., Wasserstein, Melissa P., Kenny, Eimear E., Gelb, Bruce D., and Ferket, Bart S.

Published
2024
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9. Circulating Metabolomic Associations with Neurocognitive Outcomes in Pediatric CKD

Author

Lee, Arthur M., Xu, Yunwen, Hooper, Stephen R., Abraham, Alison G., Hu, Jian, Xiao, Rui, Matheson, Matthew B., Brunson, Celina, Rhee, Eugene P., Coresh, Josef, Vasan, Ramachandran S., Schrauben, Sarah, Kimmel, Paul L., Warady, Bradley A., Furth, Susan L., Hartung, Erum A., Denburg, Michelle R., Abraham, Alison, Anderson, Amanda, Ballard, Shawn, Bonventre, Joseph, Clish, Clary, Collins, Heather, Coca, Steven, Coresh, Josef, Deo, Rajat, Denburg, Michelle, Dubin, Ruth, Feldman, Harold I., Ferket, Bart S., Foster, Meredith, Furth, Susan, Ganz, Peter, Gossett, Daniel, Grams, Morgan, Greenberg, Jason, Gutiérrez, Orlando M., Hostetter, Tom, Inker, Lesley A., Ix, Joachim, Kimmel, Paul L., Klein, Jon, Levey, Andrew S., Massaro, Joseph, McMahon, Gearoid, Mifflin, Theodore, Nadkarni, Girish N., Parikh, Chirag, Ramachandran, Vasan S., Rebholz, Casey, Rhee, Eugene, Rovin, Brad, Sarnak, M., Sabbisetti, Venkata, Schelling, Jeffrey, Seegmiller, Jesse, Shlipak, Michael G., Shou, Haochang, Tin, Adriene, Waikar, Sushrut, Warady, Bradley, Whitehead, Krista, and Xie, Dawei

Published
2024
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11. Association of Uremic Solutes With Cardiovascular Death in Diabetic Kidney Disease

Author

Massaro, Joseph, Clish, Clary, Denburg, Michelle, Furth, Susan, Warady, Bradley, Bonventre, Joseph, Waikar, Sushrut, McMahon, Gearoid, Sabbisetti, Venkata, Coresh, Josef, Grams, Morgan, Rebholz, Casey, Abraham, Alison, Tin, Adriene, Parikh, Chirag, Klein, Jon, Coca, Steven, Ferket, Bart S., Nadkarni, Girish N., Gossett, Daniel, Rovin, Brad, Levey, Andrew S., Inker, Lesley A., Foster, Meredith, Dubin, Ruth, Deo, Rajat, Anderson, Amanda, Mifflin, Theodore, Xie, Dawei, Shou, Haochang, Ballard, Shawn, Whitehead, Krista, Collins, Heather, Greenberg, Jason, Ganz, Peter, Sapa, Hima, Gutiérrez, Orlando M., Shlipak, Michael G., Katz, Ronit, Ix, Joachim H., Sarnak, Mark J., Cushman, Mary, Rhee, Eugene P., Kimmel, Paul L., Vasan, Ramachandran S., Schrauben, Sarah J., Feldman, Harold I., Seegmiller, Jesse C., Brunengraber, Henri, Hostetter, Thomas H., and Schelling, Jeffrey R.

Published
2022
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12. Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network

Author

Ginsburg, Geoffrey S., Cavallari, Larisa H., Chakraborty, Hrishikesh, Cooper-DeHoff, Rhonda M., Dexter, Paul R., Eadon, Michael T., Ferket, Bart S., Horowitz, Carol R., Johnson, Julie A., Kannry, Joseph, Kucher, Natalie, Madden, Ebony B., Orlando, Lori A., Parker, Wanda, Peterson, Josh, Pratt, Victoria M., Rakhra-Burris, Tejinder K., Ramos, Michelle A., Skaar, Todd C., Sperber, Nina, Steen-Burrell, Kady-Ann, Van Driest, Sara L., Voora, Deepak, Wiisanen, Kristin, Winterstein, Almut G., Volpi, Simona, Montgomery, Aisha, Kitzman, Heather, Sadeghpour, Azita, Garrett-Mead, Nancy, Wu, R. Ryanne, Rakhra-Burris, Tejinder, Dexter, Paul, Lynch, Sheryl, Skaar, Todd, Pratt, Victoria, Nauman, Beth, Johnson, Erica, Ferket, Bart, Hauser, Diane, Ramos, Michelle, Ferket, Mart, Shroff, Nandini, Calman, Neil, Clermont, Sabrina, Shuman, Saskia, Singh, Rajbir, Madden, Ebony, Blake, Kathryn, Duong, Benjamin Quang, Free, Colette, Hines, Lindsay, Roberts, Joseph, Elsey, Amanda, Elwood, Erica, Johnson, Julie, Cavallari, Larisa, Cooper-DeHoff, Rhonda, Parker, Alex, Vigal, Kim, Fuloria, Jyotsna, Revels, Asa, Beasley, Cherry, Ong, Henry, Cavanaugh, Kerri, and Van Driest, Sara

Published
2021
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13. Cost-effectiveness of coronary artery bypass grafting plus mitral valve repair versus coronary artery bypass grafting alone for moderate ischemic mitral regurgitation

Author

Miller, Marissa A., Taddei-Peters, Wendy C., Buxton, Dennis, Caulder, Ron, Geller, Nancy L., Gordon, David, Jeffries, Neal O., Lee, Albert, Moy, Claudia S., Gombos, Ilana Kogan, Ralph, Jennifer, Weisel, Richard, Gardner, Timothy J., O'Gara, Patrick T., Rose, Eric A., Gelijns, Annetine C., Parides, Michael K., Ascheim, Deborah D., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, Chang, Helena, Chase, Melissa, Chen, Yingchun, Goldfarb, Seth, Gupta, Lopa, Kirkwood, Katherine, Dobrev, Edlira, Levitan, Ron, O'Sullivan, Karen, Overbey, Jessica, Santos, Milerva, Weglinski, Michael, Williams, Paula, Wood, Carrie, Ye, Xia, Nielsen, Sten Lyager, Wiggers, Henrik, Malgaard, Henning, Mack, Michael, Adame, Tracine, Settele, Natalie, Adams, Jenny, Ryan, William, Smith, Robert L., Grayburn, Paul, Chen, Frederick Y., Nohria, Anju, Cohn, Lawrence, Shekar, Prem, Aranki, Sary, Couper, Gregory, Davidson, Michael, Bolman, R. Morton, III, Burgess, Anne, Conboy, Debra, Noiseux, Nicolas, Stevens, Louis-Mathieu, Prieto, Ignacio, Basile, Fadi, Dionne, Joannie, Fecteau, Julie, Blackstone, Eugene H., Gillinov, A. Marc, Lackner, Pamela, Berroteran, Leoma, Dolney, Diana, Fleming, Suzanne, Palumbo, Roberta, Whitman, Christine, Sankovic, Kathy, Sweeney, Denise Kosty, Pattakos, Gregory, Clarke, Pamela A., Argenziano, Michael, Williams, Mathew, Goldsmith, Lyn, Smith, Craig R., Naka, Yoshifumi, Stewart, Allan, Schwartz, Allan, Bell, Daniel, Van Patten, Danielle, Sreekanth, Sowmya, Smith, Peter K., Alexander, John H., Milano, Carmelo A., Glower, Donald D., Mathew, Joseph P., Harrison, J. Kevin, Welsh, Stacey, Berry, Mark F., Parsa, Cyrus J., Tong, Betty C., Williams, Judson B., Ferguson, T. Bruce, Kypson, Alan P., Rodriguez, Evelio, Harris, Malissa, Akers, Brenda, O'Neal, Allison, Puskas, John D., Thourani, Vinod H., Guyton, Robert, Baer, Jefferson, Baio, Kim, Neill, Alexis A., Voisine, Pierre, Senechal, Mario, Dagenais, François, O'Connor, Kim, Dussault, Gladys, Ballivian, Tatiana, Keilani, Suzanne, Speir, Alan M., Magee, Patrick, Ad, Niv, Keyte, Sally, Dang, Minh, Slaughter, Mark, Headlee, Marsha, Moody, Heather, Solankhi, Naresh, Birks, Emma, Groh, Mark A., Shell, Leslie E., Shepard, Stephanie A., Trichon, Benjamin H., Nanney, Tracy, Hampton, Lynne C., Michler, Robert E., D'Alessandro, David A., DeRose, Joseph J., Jr., Goldstein, Daniel J., Bello, Ricardo, Jakobleff, William, Garcia, Mario, Taub, Cynthia, Spevak, Daniel, Swayze, Roger, Perrault, Louis P., Basmadjian, Arsène-Joseph, Bouchard, Denis, Carrier, Michel, Cartier, Raymond, Pellerin, Michel, Tanguay, Jean François, El-Hamamsy, Ismail, Denault, André, Demers, Philippe, Robichaud, Sophie, Horvath, Keith A., Corcoran, Philip C., Siegenthaler, Michael P., Murphy, Mandy, Iraola, Margaret, Greenberg, Ann, Sai-Sudhakar, Chittoor, Hasan, Ayseha, McDavid, Asia, Kinn, Bradley, Pagé, Pierre, Sirois, Carole, Latter, David, Leong-Poi, Howard, Bonneau, Daniel, Errett, Lee, Peterson, Mark D., Verma, Subodh, Feder-Elituv, Randi, Cohen, Gideon, Joyner, Campbell, Fremes, Stephen E., Moussa, Fuad, Christakis, George, Karkhanis, Reena, Yau, Terry, Farkouh, Michael, Woo, Anna, Cusimano, Robert James, David, Tirone, Feindel, Christopher, Garrard, Lisa, Fredericks, Suzanne, Mociornita, Amelia, Mullen, John C., Choy, Jonathan, Meyer, Steven, Kuurstra, Emily, Gammie, James S., Young, Cindi A., Beach, Dana, Acker, Michael A., Atluri, Pavan, Woo, Y. Joseph, Mayer, Mary Lou, Bowdish, Michael, Starnes, Vaughn A., Shavalle, David, Matthews, Ray, Javadifar, Shadi, Romar, Linda, Kron, Irving L., Ailawadi, Gorav, Johnston, Karen, Dent, John M., Kern, John, Keim, Jessica, Burks, Sandra, Gahring, Kim, Bull, David A., Desvigne-Nickens, Patrice, Dixon, Dennis O., Haigney, Mark, Holubkov, Richard, Jacobs, Alice, Miller, Frank, Murkin, John M., Spertus, John, Wechsler, Andrew S., Sellke, Frank, McDonald, Cheryl L., Byington, Robert, Dickert, Neal, Ikonomidis, John S., Williams, David O., Yancy, Clyde W., Fang, James C., Giannetti, Nadia, Richenbacher, Wayne, Rao, Vivek, Furie, Karen L., Miller, Rachel, Pinney, Sean, Roberts, William C., Walsh, Mary N., Keteyian, Stephen J., Brawner, Clinton A., Aldred, Heather, Hung, Judy, Zeng, Xin, Browndyke, Jeffrey, Toulgoat-Dubois, Yanne, Ferket, Bart S., Hohmann, Samuel F., Chang, Helena L., Mick, Stephanie L., Hung, Judy W., Overbey, Jessica R., and Lala, Anuradha

Published
2020
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14. Potential Mediators for Treatment Effects of Novel Diabetes Medications on Cardiovascular and Renal Outcomes: A Meta‐Regression Analysis

Author

Rodriguez‐Valadez, José M., primary, Tahsin, Malak, additional, Masharani, Umesh, additional, Park, Meyeon, additional, Hunink, M. G. Myriam, additional, Yeboah, Joseph, additional, Li, Lihua, additional, Weber, Ellerie, additional, Berkalieva, Asem, additional, Avezaat, Luuk, additional, Max, Wendy, additional, Fleischmann, Kirsten E., additional, and Ferket, Bart S., additional

Published
2024
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17. Correction to: The NYCKidSeq project: study protocol for a randomized controlled trial incorporating genomics into the clinical care of diverse New York City children

Author

Odgis, Jacqueline A., Gallagher, Katie M., Suckiel, Sabrina A., Donohue, Katherine E., Ramos, Michelle A., Kelly, Nicole R., Bertier, Gabrielle, Blackburn, Christina, Brown, Kaitlyn, Fielding, Lena, Lopez, Jessenia, Aguiniga, Karla Lopez, Maria, Estefany, Rodriguez, Jessica E., Sebastin, Monisha, Teitelman, Nehama, Watnick, Dana, Yelton, Nicole M., Abhyankar, Avinash, Abul-Husn, Noura S., Baum, Aaron, Bauman, Laurie J., Beal, Jules C., Bloom, Toby, Cunningham-Rundles, Charlotte, Diaz, George A., Dolan, Siobhan, Ferket, Bart S., Jobanputra, Vaidehi, Kovatch, Patricia, McDonald, Thomas V., McGoldrick, Patricia E., Rhodes, Rosamond, Rinke, Michael L., Robinson, Mimsie, Rubinstein, Arye, Shulman, Lisa H., Stolte, Christian, Wolf, Steven M., Yozawitz, Elissa, Zinberg, Randi E., Greally, John M., Gelb, Bruce D., Horowitz, Carol R., Wasserstein, Melissa P., and Kenny, Eimear E.

Published
2021
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22. Physician services and costs after disclosure of diagnostic sequencing results in the NYCKidSeq program

Author

Berkalieva, Asem, primary, Kelly, Nicole R., additional, Fisher, Ashley, additional, Hohmann, Samuel F., additional, Sebastin, Monisha, additional, Di Biase, Miranda, additional, Bonini, Katherine E., additional, Marathe, Priya, additional, Odgis, Jacqueline A., additional, Suckiel, Sabrina A., additional, Ramos, Michelle A., additional, Rhodes, Rosamond, additional, Abul-Husn, Noura S., additional, Greally, John M., additional, Horowitz, Carol R., additional, Wasserstein, Melissa P., additional, Kenny, Eimear E., additional, Gelb, Bruce D., additional, and Ferket, Bart S., additional

Published
2023
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23. Association of Integrated Proteomic and Metabolomic Modules with Risk of Kidney Disease Progression

Author

Schlosser, Pascal, Surapaneni, Aditya L., Borisov, Oleg, Schmidt, Insa M., Zhou, Linda, Anderson, Amanda, Deo, Rajat, Dubin, Ruth, Ganz, Peter, He, Jiang, Kimmel, Paul L., Li, Hongzhe, Nelson, Robert G., Porter, Anna C., Rahman, Mahboob, Rincon-Choles, Hernan, Shah, Vallabh, Unruh, Mark L., Vasan, Ramachandran S., Zheng, Zihe, Feldman, Harold I., Waikar, Sushrut S., Köttgen, Anna, Rhee, Eugene P., Coresh, Josef, Grams, Morgan E., Anderson, Amanda H., Appel, Lawrence J., Chen, Jing, Cohen, Debbie L., Dember, Laura M., Go, Alan S., Lash, James P., Rao, Panduranga S., Waikar, Sushrut, Schelling, Jeffrey, Denburg, Michelle, Furth, Susan, Warady, Bradley, Bonventre, Joseph, McMahon, Gearoid, Sabbisetti, Venkata, Coresh, Josef, Grams, Morgan, Rebholz, Casey, Abraham, Alison, Tin, Adriene, Parikh, Chirag, Klein, Jon, Coca, Steven, Ferket, Bart S., Nadkarni, Girish N., Rhee, Eugene, Kimmel, Paul L., Gossett, Daniel, Rovin, Brad, Shlipak, Michael G., Sarnak, M., Levey, Andrew S., Inker, Lesley A., Foster, Meredith, Gutiérrez, Orlando M., Ix, Joachim, Dubin, Ruth, Seegmiller, Jesse, Hostetter, Tom, Deo, Rajat, Li, Hongzhe, Ren, Yue, Schrauben, Sarah J., Feldman, Harold I., Anderson, Amanda, Mifflin, Theodore, Xie, Dawei, Shou, Haochang, Ballard, Shawn, Whitehead, Krista, Collins, Heather, Ramachandran, Vasan S., Greenberg, Jason, and Ganz, Peter

Published
2024
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25. Cardiovascular and Renal Benefits of Novel Diabetes Drugs by Baseline Cardiovascular Risk: A Systematic Review, Meta-analysis, and Meta-regression

Author

Rodriguez-Valadez, José M., primary, Tahsin, Malak, additional, Fleischmann, Kirsten E., additional, Masharani, Umesh, additional, Yeboah, Joseph, additional, Park, Meyeon, additional, Li, Lihua, additional, Weber, Ellerie, additional, Li, Yan, additional, Berkalieva, Asem, additional, Max, Wendy, additional, Hunink, M.G. Myriam, additional, and Ferket, Bart S., additional

Published
2023
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27. Abstract P140: Potential Mediators for Cardiovascular Benefits of Novel Diabetes Medications: A Meta-Regression Analysis

Author

Rodriguez Valadez, Jose M, primary, Tahsin, Malak, additional, Masharani, Umesh, additional, Park, Meyeon, additional, Hunink, M.G. Myriam, additional, Yeboah, Joseph, additional, Li, Lihua, additional, Weber, Ellerie, additional, Li, Yan, additional, Berkalieva, Asem, additional, Avezaat, Luuk, additional, Max, Wendy, additional, Fleischmann, Kirsten E, additional, and Ferket, Bart S, additional

Published
2023
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30. Cost-Effectiveness of Mitral Valve Repair Versus Replacement for Severe Ischemic Mitral Regurgitation: A Randomized Clinical Trial From the Cardiothoracic Surgical Trials Network

Author

Ferket, Bart S., Ailawadi, Gorav, Gelijns, Annetine C., Acker, Michael A., Hohmann, Samuel F., Chang, Helena L., Bouchard, Denis, Meltzer, David O., Michler, Robert E., Moquete, Ellen G., Voisine, Pierre, Mullen, John C., Lala, Anuradha, Mack, Michael J., Gillinov, A. Marc, Thourani, Vinod H., Miller, Marissa A., Gammie, James S., Parides, Michael K., Bagiella, Emilia, Smith, Robert L., Smith, Peter K., Hung, Judy W., Gupta, Lopa N., Rose, Eric A., O’Gara, Patrick T., and Moskowitz, Alan J.

Published
2018
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31. Cost-effectiveness frameworks for comparing genome and exome sequencing versus conventional diagnostic pathways: A scoping review and recommended methods

Author

Ferket, Bart S., primary, Baldwin, Zach, additional, Murali, Priyanka, additional, Pai, Akila, additional, Mittendorf, Kathleen F., additional, Russell, Heidi V., additional, Chen, Flavia, additional, Lynch, Frances L., additional, Lich, Kristen Hassmiller, additional, Hindorff, Lucia A., additional, Savich, Renate, additional, Slavotinek, Anne, additional, Smith, Hadley Stevens, additional, Gelb, Bruce D., additional, and Veenstra, David L., additional

Published
2022
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32. Association of Uremic Solutes With Cardiovascular Death in Diabetic Kidney Disease

Author

Sapa, Hima, primary, Gutiérrez, Orlando M., additional, Shlipak, Michael G., additional, Katz, Ronit, additional, Ix, Joachim H., additional, Sarnak, Mark J., additional, Cushman, Mary, additional, Rhee, Eugene P., additional, Kimmel, Paul L., additional, Vasan, Ramachandran S., additional, Schrauben, Sarah J., additional, Feldman, Harold I., additional, Seegmiller, Jesse C., additional, Brunengraber, Henri, additional, Hostetter, Thomas H., additional, Schelling, Jeffrey R., additional, Massaro, Joseph, additional, Clish, Clary, additional, Denburg, Michelle, additional, Furth, Susan, additional, Warady, Bradley, additional, Bonventre, Joseph, additional, Waikar, Sushrut, additional, McMahon, Gearoid, additional, Sabbisetti, Venkata, additional, Coresh, Josef, additional, Grams, Morgan, additional, Rebholz, Casey, additional, Abraham, Alison, additional, Tin, Adriene, additional, Parikh, Chirag, additional, Klein, Jon, additional, Coca, Steven, additional, Ferket, Bart S., additional, Nadkarni, Girish N., additional, Gossett, Daniel, additional, Rovin, Brad, additional, Levey, Andrew S., additional, Inker, Lesley A., additional, Foster, Meredith, additional, Dubin, Ruth, additional, Deo, Rajat, additional, Anderson, Amanda, additional, Mifflin, Theodore, additional, Xie, Dawei, additional, Shou, Haochang, additional, Ballard, Shawn, additional, Whitehead, Krista, additional, Collins, Heather, additional, Greenberg, Jason, additional, and Ganz, Peter, additional

Published
2022
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37. Additional file 1 of The NYCKidSeq project: study protocol for a randomized controlled trial incorporating genomics into the clinical care of diverse New York City children

Author

Odgis, Jacqueline A., Gallagher, Katie M., Suckiel, Sabrina A., Donohue, Katherine E., Ramos, Michelle A., Kelly, Nicole R., Bertier, Gabrielle, Blackburn, Christina, Brown, Kaitlyn, Fielding, Lena, Jessenia Lopez, Aguiniga, Karla Lopez, Estefany Maria, Rodriguez, Jessica E., Sebastin, Monisha, Nehama Teitelman, Watnick, Dana, Yelton, Nicole M., Abhyankar, Avinash, Abul-Husn, Noura S., Baum, Aaron, Bauman, Laurie J., Beal, Jules C., Bloom, Toby, Cunningham-Rundles, Charlotte, Diaz, George A., Dolan, Siobhan, Ferket, Bart S., Vaidehi Jobanputra, Kovatch, Patricia, McDonald, Thomas V., McGoldrick, Patricia E., Rhodes, Rosamond, Rinke, Michael L., Mimsie Robinson, Rubinstein, Arye, Shulman, Lisa H., Stolte, Christian, Wolf, Steven M., Yozawitz, Elissa, Zinberg, Randi E., Greally, John M., Gelb, Bruce D., Horowitz, Carol R., Wasserstein, Melissa P., and Kenny, Eimear E.

Abstract

Additional file 1. SPIRIT checklist.

Published
2021
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40. Estimating Long-Term Health Utility Scores and Expenditures for Cardiovascular Disease From the Medical Expenditure Panel Survey

Author

Morey, Jacob R., Jiang, Shangqing, Klein, Sharon, Max, Wendy, Masharani, Umesh, Fleischmann, Kirsten E., Hunink, M. G.Myriam, Ferket, Bart S., Morey, Jacob R., Jiang, Shangqing, Klein, Sharon, Max, Wendy, Masharani, Umesh, Fleischmann, Kirsten E., Hunink, M. G.Myriam, and Ferket, Bart S.

Abstract

Background: Long-term health utility scores and costs used in cost-effectiveness analyses of cardiovascular disease prevention and management can be inconsistent, outdated, or invalid for the diverse population of the United States. Our aim was to develop a user friendly, standardized, publicly available code and catalog to derive more valid long-term values for health utility and expenditures following cardiovascular disease events. Methods: Individual-level Short Form-12 version 2 health-related quality of life and expenditure data were obtained from the pooled 2011 to 2016 Medical Expenditure Panel Surveys. We developed code using the R programming language to estimate preference-weighted Short Form-6D utility scores from the Short Form-12 for quality-adjusted life year calculations and predict annual health care expenditures. Result predictors included cardiovascular disease diagnosis (myocardial infarction, ischemic stroke, heart failure, cardiac dysrhythmias, angina pectoris, and peripheral artery disease), sociodemographic factors, and comorbidity variables. Results: The cardiovascular disease diagnoses with the lowest utility scores were heart failure (0.635 [95% CI, 0.615-0.655]), angina pectoris (0.649 [95% CI, 0.630-0.667]), and ischemic stroke (0.649 [95% CI, 0.635-0.663]). The highest annual expenditures were for heart failure ($20 764 [95% CI, $17 500-$24 027]), angina pectoris ($18 428 [95% CI, $16 102-$20 754]), and ischemic stroke ($16 925 [95% CI, $15 672-$20 616]). Conclusions: The developed code and catalog may improve the quality and comparability of cost-effectiveness analyses by providing standardized methods for extracting long-term health utility scores and expenditures from Medical Expenditure Panel Survey data, which are more current and representative of the US population than previous sources.

Published
2021

44. The NYCKidSeq project: study protocol for a randomized controlled trial incorporating genomics into the clinical care of diverse New York City children

Author

Odgis, Jacqueline A., primary, Gallagher, Katie M., additional, Suckiel, Sabrina A., additional, Donohue, Katherine E., additional, Ramos, Michelle A., additional, Kelly, Nicole R., additional, Bertier, Gabrielle, additional, Blackburn, Christina, additional, Brown, Kaitlyn, additional, Fielding, Lena, additional, Lopez, Jessenia, additional, Aguiniga, Karla Lopez, additional, Maria, Estefany, additional, Rodriguez, Jessica E., additional, Sebastin, Monisha, additional, Teitelman, Nehama, additional, Watnick, Dana, additional, Yelton, Nicole M., additional, Abhyankar, Avinash, additional, Abul-Husn, Noura S., additional, Baum, Aaron, additional, Bauman, Laurie J., additional, Beal, Jules C., additional, Bloom, Toby, additional, Cunningham-Rundles, Charlotte, additional, Diaz, George A., additional, Dolan, Siobhan, additional, Ferket, Bart S., additional, Jobanputra, Vaidehi, additional, Kovatch, Patricia, additional, McDonald, Thomas V., additional, McGoldrick, Patricia E., additional, Rhodes, Rosamond, additional, Rinke, Michael L., additional, Robinson, Mimsie, additional, Rubinstein, Arye, additional, Shulman, Lisa H., additional, Stolte, Christian, additional, Wolf, Steven M., additional, Yozawitz, Elissa, additional, Zinberg, Randi E., additional, Greally, John M., additional, Gelb, Bruce D., additional, Horowitz, Carol R., additional, Wasserstein, Melissa P., additional, and Kenny, Eimear E., additional

Published
2021
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45. The NYCKidSeq project: study protocol for a randomized controlled trial incorporating genomics into the clinical care of diverse New York City children

Author

Odgis, Jacqueline A, primary, Gallagher, Katie M., additional, Suckiel, Sabrina A., additional, Donohue, Katherine E., additional, Ramos, Michelle A., additional, Kelly, Nicole R., additional, Bertier, Gabrielle, additional, Blackburn, Christina, additional, Brown, Kaitlyn, additional, Fielding, Lena, additional, Lopez, Jessenia, additional, Aguiniga, Karla Lopez, additional, Maria, Estefany, additional, Rodriguez, Jessica E., additional, Sebastin, Monisha, additional, Teitelman, Nehama, additional, Watnick, Dana, additional, Yelton, Nicole M., additional, Abhyankar, Avinash, additional, Abul-Husn, Noura S., additional, Baum, Aaron, additional, Bauman, Laurie J., additional, Beal, Jules C., additional, Bloom, Toby, additional, Cunningham-Rundles, Charlotte, additional, Diaz, George A., additional, Dolan, Siobhan, additional, Ferket, Bart S., additional, Jobanputra, Vaidehi, additional, Kovatch, Patricia, additional, McDonald, Thomas V., additional, McGoldrick, Patricia E., additional, Rhodes, Rosamond, additional, Rinke, Michael L., additional, Robinson, Mimsie, additional, Rubinstein, Arye, additional, Shulman, Lisa H., additional, Stolte, Christian, additional, Wolf, Steven M., additional, Yozawitz, Elissa, additional, Zinberg, Randi E., additional, Greally, John M., additional, Gelb, Bruce D., additional, Horowitz, Carol R., additional, Wasserstein, Melissa P., additional, and Kenny, Eimear E., additional

Published
2020
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46. Developing an Institute for Health Care Delivery Science: successes, challenges, and solutions in the first five years

Author

Mazumdar, Madhu, primary, Poeran, Jashvant V., additional, Ferket, Bart S., additional, Zubizarreta, Nicole, additional, Agarwal, Parul, additional, Gorbenko, Ksenia, additional, Craven, Catherine K., additional, Zhong, Xiaobo, additional, Moskowitz, Alan J., additional, Gelijns, Annetine C., additional, and Reich, David L., additional

Published
2020
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47. The NYCKidSeq project: study protocol for a randomized controlled trial incorporating genomics into the clinical care of diverse New York City children

Author

Odgis, Jacqueline A., primary, Gallagher, Katie M., additional, Suckiel, Sabrina A., additional, Donohue, Katherine E., additional, Ramos, Michelle A., additional, Kelly, Nicole R., additional, Bertier, Gabrielle, additional, Blackburn, Christina, additional, Brown, Kaitlyn, additional, Fielding, Lena, additional, Lopez, Jessenia, additional, Aguiniga, Karla Lopez, additional, Maria, Estefany, additional, Rodriguez, Jessica E., additional, Sebastin, Monisha, additional, Teitelman, Nehama, additional, Watnick, Dana, additional, Yelton, Nicole M., additional, Abhyankar, Avinash, additional, Abul-Husn, Noura S., additional, Baum, Aaron, additional, Bauman, Laurie J., additional, Beal, Jules C., additional, Bloom, Toby, additional, Cunningham-Rundles, Charlotte, additional, Diaz, George A., additional, Dolan, Siobhan, additional, Ferket, Bart S., additional, Jobanputra, Vaidehi, additional, Kovatch, Patricia, additional, McDonald, Thomas V., additional, McGoldrick, Patricia E., additional, Rhodes, Rosamond, additional, Rinke, Michael L., additional, Robinson, Mimsie, additional, Rubinstein, Arye, additional, Shulman, Lisa H., additional, Stolte, Christian, additional, Wolf, Steven M., additional, Yozawitz, Elissa, additional, Zinberg, Randi E., additional, Greally, John M., additional, Gelb, Bruce D., additional, Horowitz, Carol R., additional, Wasserstein, Melissa P., additional, and Kenny, Eimear E., additional

Published
2020
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48. Cost-effectiveness of Contemporary Statin Use Guidelines With or Without Coronary Artery Calcium Assessment in African American Individuals

Author

Spahillari, Aferdita, primary, Zhu, Jinyi, additional, Ferket, Bart S., additional, Hunink, M. G. Myriam, additional, Carr, J. Jeffrey, additional, Terry, James G., additional, Nelson, Cheryl, additional, Mwasongwe, Stanford, additional, Mentz, Robert J., additional, O’Brien, Emily C., additional, Correa, Adolfo, additional, Shah, Ravi V., additional, Murthy, Venkatesh L., additional, and Pandya, Ankur, additional

Published
2020
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50. Cost-effectiveness of coronary artery bypass grafting plus mitral valve repair versus coronary artery bypass grafting alone for moderate ischemic mitral regurgitation

Author

Ferket, Bart S., primary, Thourani, Vinod H., additional, Voisine, Pierre, additional, Hohmann, Samuel F., additional, Chang, Helena L., additional, Smith, Peter K., additional, Michler, Robert E., additional, Ailawadi, Gorav, additional, Perrault, Louis P., additional, Miller, Marissa A., additional, O'Sullivan, Karen, additional, Mick, Stephanie L., additional, Bagiella, Emilia, additional, Acker, Michael A., additional, Moquete, Ellen, additional, Hung, Judy W., additional, Overbey, Jessica R., additional, Lala, Anuradha, additional, Iraola, Margaret, additional, Gammie, James S., additional, Gelijns, Annetine C., additional, O'Gara, Patrick T., additional, Moskowitz, Alan J., additional, Taddei-Peters, Wendy C., additional, Buxton, Dennis, additional, Caulder, Ron, additional, Geller, Nancy L., additional, Gordon, David, additional, Jeffries, Neal O., additional, Lee, Albert, additional, Moy, Claudia S., additional, Gombos, Ilana Kogan, additional, Ralph, Jennifer, additional, Weisel, Richard, additional, Gardner, Timothy J., additional, Rose, Eric A., additional, Parides, Michael K., additional, Ascheim, Deborah D., additional, Chang, Helena, additional, Chase, Melissa, additional, Chen, Yingchun, additional, Goldfarb, Seth, additional, Gupta, Lopa, additional, Kirkwood, Katherine, additional, Dobrev, Edlira, additional, Levitan, Ron, additional, Overbey, Jessica, additional, Santos, Milerva, additional, Weglinski, Michael, additional, Williams, Paula, additional, Wood, Carrie, additional, Ye, Xia, additional, Nielsen, Sten Lyager, additional, Wiggers, Henrik, additional, Malgaard, Henning, additional, Mack, Michael, additional, Adame, Tracine, additional, Settele, Natalie, additional, Adams, Jenny, additional, Ryan, William, additional, Smith, Robert L., additional, Grayburn, Paul, additional, Chen, Frederick Y., additional, Nohria, Anju, additional, Cohn, Lawrence, additional, Shekar, Prem, additional, Aranki, Sary, additional, Couper, Gregory, additional, Davidson, Michael, additional, Bolman, R. Morton, additional, Burgess, Anne, additional, Conboy, Debra, additional, Noiseux, Nicolas, additional, Stevens, Louis-Mathieu, additional, Prieto, Ignacio, additional, Basile, Fadi, additional, Dionne, Joannie, additional, Fecteau, Julie, additional, Blackstone, Eugene H., additional, Gillinov, A. Marc, additional, Lackner, Pamela, additional, Berroteran, Leoma, additional, Dolney, Diana, additional, Fleming, Suzanne, additional, Palumbo, Roberta, additional, Whitman, Christine, additional, Sankovic, Kathy, additional, Sweeney, Denise Kosty, additional, Pattakos, Gregory, additional, Clarke, Pamela A., additional, Argenziano, Michael, additional, Williams, Mathew, additional, Goldsmith, Lyn, additional, Smith, Craig R., additional, Naka, Yoshifumi, additional, Stewart, Allan, additional, Schwartz, Allan, additional, Bell, Daniel, additional, Van Patten, Danielle, additional, Sreekanth, Sowmya, additional, Alexander, John H., additional, Milano, Carmelo A., additional, Glower, Donald D., additional, Mathew, Joseph P., additional, Harrison, J. Kevin, additional, Welsh, Stacey, additional, Berry, Mark F., additional, Parsa, Cyrus J., additional, Tong, Betty C., additional, Williams, Judson B., additional, Ferguson, T. Bruce, additional, Kypson, Alan P., additional, Rodriguez, Evelio, additional, Harris, Malissa, additional, Akers, Brenda, additional, O'Neal, Allison, additional, Puskas, John D., additional, Guyton, Robert, additional, Baer, Jefferson, additional, Baio, Kim, additional, Neill, Alexis A., additional, Senechal, Mario, additional, Dagenais, François, additional, O'Connor, Kim, additional, Dussault, Gladys, additional, Ballivian, Tatiana, additional, Keilani, Suzanne, additional, Speir, Alan M., additional, Magee, Patrick, additional, Ad, Niv, additional, Keyte, Sally, additional, Dang, Minh, additional, Slaughter, Mark, additional, Headlee, Marsha, additional, Moody, Heather, additional, Solankhi, Naresh, additional, Birks, Emma, additional, Groh, Mark A., additional, Shell, Leslie E., additional, Shepard, Stephanie A., additional, Trichon, Benjamin H., additional, Nanney, Tracy, additional, Hampton, Lynne C., additional, D'Alessandro, David A., additional, DeRose, Joseph J., additional, Goldstein, Daniel J., additional, Bello, Ricardo, additional, Jakobleff, William, additional, Garcia, Mario, additional, Taub, Cynthia, additional, Spevak, Daniel, additional, Swayze, Roger, additional, Basmadjian, Arsène-Joseph, additional, Bouchard, Denis, additional, Carrier, Michel, additional, Cartier, Raymond, additional, Pellerin, Michel, additional, Tanguay, Jean François, additional, El-Hamamsy, Ismail, additional, Denault, André, additional, Demers, Philippe, additional, Robichaud, Sophie, additional, Horvath, Keith A., additional, Corcoran, Philip C., additional, Siegenthaler, Michael P., additional, Murphy, Mandy, additional, Greenberg, Ann, additional, Sai-Sudhakar, Chittoor, additional, Hasan, Ayseha, additional, McDavid, Asia, additional, Kinn, Bradley, additional, Pagé, Pierre, additional, Sirois, Carole, additional, Latter, David, additional, Leong-Poi, Howard, additional, Bonneau, Daniel, additional, Errett, Lee, additional, Peterson, Mark D., additional, Verma, Subodh, additional, Feder-Elituv, Randi, additional, Cohen, Gideon, additional, Joyner, Campbell, additional, Fremes, Stephen E., additional, Moussa, Fuad, additional, Christakis, George, additional, Karkhanis, Reena, additional, Yau, Terry, additional, Farkouh, Michael, additional, Woo, Anna, additional, Cusimano, Robert James, additional, David, Tirone, additional, Feindel, Christopher, additional, Garrard, Lisa, additional, Fredericks, Suzanne, additional, Mociornita, Amelia, additional, Mullen, John C., additional, Choy, Jonathan, additional, Meyer, Steven, additional, Kuurstra, Emily, additional, Young, Cindi A., additional, Beach, Dana, additional, Atluri, Pavan, additional, Woo, Y. Joseph, additional, Mayer, Mary Lou, additional, Bowdish, Michael, additional, Starnes, Vaughn A., additional, Shavalle, David, additional, Matthews, Ray, additional, Javadifar, Shadi, additional, Romar, Linda, additional, Kron, Irving L., additional, Johnston, Karen, additional, Dent, John M., additional, Kern, John, additional, Keim, Jessica, additional, Burks, Sandra, additional, Gahring, Kim, additional, Bull, David A., additional, Desvigne-Nickens, Patrice, additional, Dixon, Dennis O., additional, Haigney, Mark, additional, Holubkov, Richard, additional, Jacobs, Alice, additional, Miller, Frank, additional, Murkin, John M., additional, Spertus, John, additional, Wechsler, Andrew S., additional, Sellke, Frank, additional, McDonald, Cheryl L., additional, Byington, Robert, additional, Dickert, Neal, additional, Ikonomidis, John S., additional, Williams, David O., additional, Yancy, Clyde W., additional, Fang, James C., additional, Giannetti, Nadia, additional, Richenbacher, Wayne, additional, Rao, Vivek, additional, Furie, Karen L., additional, Miller, Rachel, additional, Pinney, Sean, additional, Roberts, William C., additional, Walsh, Mary N., additional, Keteyian, Stephen J., additional, Brawner, Clinton A., additional, Aldred, Heather, additional, Hung, Judy, additional, Zeng, Xin, additional, Browndyke, Jeffrey, additional, and Toulgoat-Dubois, Yanne, additional

Published
2020
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