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1. 3D-Arterial analysis software and CEUS in the assessment of severity and vulnerability of carotid atherosclerotic plaque: a comparison with CTA and histopathology

Author

Fresilli, Daniele, Di Leo, Nicola, Martinelli, Ombretta, Di Marzo, Luca, Pacini, Patrizia, Dolcetti, Vincenzo, Del Gaudio, Giovanni, Canni, Fabrizio, Ricci, Ludovica Isabella, De Vito, Corrado, Caiazzo, Corrado, Carletti, Raffaella, Di Gioia, Cira, Carbone, Iacopo, Feinstein, Steven B., Catalano, Carlo, and Cantisani, Vito

Published
2022
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6. Correction: Soluble urokinase plasminogen activator receptor and cardiotoxicity in doxorubicin‑treated breast cancer patients: a prospective exploratory study

Author

Chu, Jian, primary, Tung, Lillian, additional, Atallah, Issam, additional, Wei, Changli, additional, Cobleigh, Melody, additional, Rao, Ruta, additional, Feinstein, Steven B., additional, Usha, Lydia, additional, Banach, Kathrin, additional, Reiser, Jochen, additional, and Okwuosa, Tochukwu M., additional

Published
2024
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11. Contributors

Author

Abbas, Amr E., primary, Abdelmoneim, Sahar S., additional, Abraham, Theodore, additional, Acquatella, Harry, additional, Adams, David B., additional, Addetia, Karima, additional, Afilalo, Jonathan, additional, Agarwal, Vikram, additional, Agmon, Yoram, additional, Ahmed, Mohamed, additional, Alviar, Carlos, additional, Anderson, Bonita, additional, Argulian, Edgar, additional, Asch, Federico M., additional, Aurigemma, Gerard P., additional, Axsom, Kelly, additional, Badano, Luigi P., additional, Balakrishnan, Revathi, additional, Banerji, Sourin, additional, Bangalore, Sripal, additional, Bansal, Manish, additional, Bartel, Thomas, additional, Baumann, Rebecca Lynn, additional, Baumgartner, Helmut, additional, Beigel, Roy, additional, Belcik, J. Todd, additional, Belohlavek, Marek, additional, Benenstein, Ricardo, additional, Berkowitz, Eric, additional, Bhave, Nicole M., additional, Biviano, Angelo, additional, Blank, Nimrod, additional, Bonow, Robert O., additional, Burstow, Darryl J., additional, Byrd, Benjamin, additional, Carerj, Scipione, additional, Carroll, John D., additional, Chadderdon, Scott, additional, Chaliki, Hari P., additional, Chan, Kwan-Leung, additional, Chaudhry, Farooq A., additional, Chidsey, Geoff, additional, Churzidse, Sofia, additional, Coll, Blai, additional, Cui, Vivian W., additional, Cusma-Picconne, Maurizio, additional, Dahou, Abdellaziz, additional, Dal-Bianco, Jacob P., additional, Daneshvar, Daniel A., additional, Daubert, Melissa A., additional, Davidoff, Ravin, additional, DeCara, Jeanne M., additional, Delgado-Montero, Antonia, additional, Dellefave-Castillo, Lisa, additional, Desai, Ankit A., additional, DeSouza, Kavit A., additional, Doherty, Bryan, additional, Donnino, Robert, additional, Douglas, Pamela S., additional, Dudzinski, David M., additional, Dulgheru, Raluca, additional, Dumesnil, Jean G., additional, Elkayam, Uri, additional, Erbel, Raimund, additional, Erenberg, Francine, additional, Evangelista, Arturo A., additional, Feinstein, Steven B., additional, Ferreira, Beatriz, additional, Foster, Elyse, additional, Freed, Benjamin H., additional, Gardin, Julius M., additional, Gill, Edward A., additional, Gillam, Linda, additional, Giovannone, Steven, additional, Goldberger, Mark, additional, Goldstein, Steven A., additional, Gorcsan, John, additional, Gorla, Riccardo, additional, Grapsa, Julia, additional, Grawe, Erin S., additional, Gruner, Christiane, additional, Gupta, Pooja, additional, Gurudevan, Swaminatha, additional, Hahn, Rebecca T., additional, Han, Yuchi, additional, Hellawell, Jennifer L., additional, Hillier, Samuel D., additional, Hoit, Brian D., additional, Humes, Richard, additional, Jagadeesan, Vikrant, additional, Jain, Sonia, additional, Janosi, Alexander, additional, Kahn, Peter A., additional, Kaul, Sanjiv, additional, Khandheria, Bijoy K., additional, Kim, Gene H., additional, Kim, Michael S., additional, Kimura, Bruce J., additional, King, Mary Etta, additional, Kireyev, Dmitry, additional, Kirkpatrick, James N., additional, Klein, Allan L., additional, Kohli, Payal, additional, Korcarz, Claudia E., additional, Kort, Smadar, additional, Kosmala, Wojciech, additional, Koulogiannis, Konstantinos, additional, Koutsogeorgis, Ilias, additional, Kremkau, Frederick W., additional, Krieger, Eric V., additional, Kronzon, Itzhak, additional, Kutnick, Richard T., additional, Lai, Wyman, additional, Lambert, Stephane, additional, Lancellotti, Patrizio, additional, Lang, Roberto M., additional, Lee, Alex Pui-Wai, additional, Lee, Ming Sum, additional, Lerakis, Stamatios, additional, Lessick, Jonathan, additional, Lester, Steven J., additional, Leung, Steve W., additional, LeVen, Florent, additional, Levine, Robert A., additional, Li, Qin, additional, Lima, Fabio, additional, Lindner, Jonathan R., additional, Lopez, Leo, additional, Magne, Julien, additional, Mahjoub, Haifa, additional, Mangion, Judy R., additional, Mankad, Sunil V., additional, Maragiannis, Dimitrios, additional, Marcoff, Leo, additional, Martin, Randolph P., additional, Marwick, Thomas H., additional, Massabuau, Pierre, additional, Mathur, Moses, additional, McCully, Robert, additional, McGee, Edwin C., additional, McNally, Elizabeth, additional, Mehta, Sudhir Ken, additional, Mendelson, Todd, additional, Mikati, Issam A., additional, Modesto, Karen, additional, Monaghan, Mark, additional, Mookadam, Farouk, additional, Moonen, Marie, additional, Mukherjee, Monica, additional, Müller, Silvana, additional, Mulvagh, Sharon L., additional, Muraru, Denisa, additional, Murtagh, Gillian, additional, Nagueh, Sherif F., additional, Naqvi, Tasneem Z., additional, Nathan, Sandeep, additional, Negishi, Kazuaki, additional, Nihoyannopoulos, Petros, additional, Nkomo, Vuyisile T., additional, Oechslin, Erwin, additional, Olson, Joan, additional, Palios, John, additional, Parikh, Gaurav, additional, Patel, Amit R., additional, Patel, Amit V., additional, Patel, Aneet, additional, Patel, Anupa, additional, Paterick, Timothy E., additional, Payvandi, Laila A., additional, Pedrizzetti, Gianni, additional, Pellikka, Patricia A., additional, Perk, Gila, additional, Peters, Ferande, additional, Phelan, Dermot, additional, Pibarot, Philippe, additional, Picard, Michael H., additional, Plana, Juan Carlos, additional, Popovic, Zoran B., additional, Porter, Thomas, additional, Pun, Shawn C., additional, Qasim, Atif N., additional, Quader, Nishath, additional, Quinones, Miguel A., additional, Rahko, Peter S., additional, Rakowski, Harry, additional, Rao, Rajeev V., additional, Reiken, Joseph, additional, Reisner, Shimon A., additional, Retzer, Elizabeth M., additional, Rigolin, Vera H., additional, Roberson, David A., additional, Rodgers, Keith, additional, Roper, Damian, additional, Rosenhek, Raphael, additional, Ross, Eleanor, additional, Roy, R. Raina, additional, Ruberg, Frederick L., additional, Rudski, Lawrence G., additional, Ruiz, Carlos, additional, Salcedo, Ernesto E., additional, Sanborn, Danita M. Yoerger, additional, Sardana, Vrinda, additional, Saric, Muhamed, additional, Schiller, Nelson B., additional, Schinkel, Arend F.L., additional, Schwartzenberg, Shmuel S., additional, Sengupta, Partho P., additional, Shah, Pravin M., additional, Shanewise, Jack S., additional, Shernan, Stanton K., additional, Shih, Jeffrey A., additional, Siegel, Robert J., additional, Siriwardena, Maithri, additional, Siu, Samuel, additional, Solomon, Scott D., additional, Sorrell, Vincent L., additional, Spencer, Kirk T., additional, Spiegel, Denise, additional, John Sutton, Martin St., additional, Stein, James H., additional, Stergiopoulos, Kathleen, additional, Supariwala, Azhar A., additional, Szmitko, Paul E., additional, Tajouri, Tanya H., additional, Takeuchi, Masaaki, additional, Tan, Timothy C., additional, Thomas, James D., additional, Tighe, Dennis A., additional, Todaro, Maria C., additional, Tower-Rader, Albree, additional, Tsang, Michael Y.C., additional, Tsang, Teresa S.M., additional, Tsang, Wendy, additional, Tunick, Paul A., additional, Vignon, Philippe, additional, Wafsy, Meagan M., additional, Wald, Rachel, additional, Ward, R. Parker, additional, Watanabe, Nozomi, additional, Wei, Kevin, additional, Weissman, Neil J., additional, Welsch, Mariko, additional, Wiegers, Susan, additional, Williams, Lynne, additional, Woo, Anna, additional, Wuttichaipradit, Chanwit, additional, Xie, Feng, additional, Yingchoncharoen, Teerapat, additional, Yu, Cheuk-Man, additional, Yu, Zoe, additional, Zhao, Qiong, additional, Zito, Concetta, additional, and Zoghbi, William A., additional

Published
2016
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14. Recommendations for the Assessment of Carotid Arterial Plaque by Ultrasound for the Characterization of Atherosclerosis and Evaluation of Cardiovascular Risk:From the American Society of Echocardiography

Author

Johri, Amer M., Nambi, Vijay, Naqvi, Tasneem Z., Feinstein, Steven B., Kim, Esther S.H., Park, Margaret M., Becher, Harald, Sillesen, Henrik, Johri, Amer M., Nambi, Vijay, Naqvi, Tasneem Z., Feinstein, Steven B., Kim, Esther S.H., Park, Margaret M., Becher, Harald, and Sillesen, Henrik

Abstract

Atherosclerotic plaque detection by carotid ultrasound provides cardiovascular disease risk stratification. The advantages and disadvantages of two-dimensional (2D) and three-dimensional (3D) ultrasound methods for carotid arterial plaque quantification are reviewed. Advanced and emerging methods of carotid arterial plaque activity and composition analysis by ultrasound are considered. Recommendations for the standardization of focused 2D and 3D carotid arterial plaque ultrasound image acquisition and measurement for the purpose of cardiovascular disease stratification are formulated. Potential clinical application towards cardiovascular risk stratification of recommended focused carotid arterial plaque quantification approaches are summarized.

Published
2020

18. Use of ultrasound enhancing agents in transesophageal echocardiography to improve interpretive confidence of left atrial appendage thrombus

Author

Doukky, Rami, primary, Donenberg, Merrick J., additional, Parker, Jeremy, additional, Kaplan, Jonathan, additional, Travers, Chad, additional, Soble, Jeffrey S., additional, Sattar, Payman, additional, Krishnan, Kousik, additional, Madias, Christopher, additional, Tracy, Melissa, additional, and Feinstein, Steven B., additional

Published
2018
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20. Use of ultrasound enhancing agents in transesophageal echocardiography to improve interpretive confidence of left atrial appendage thrombus.

Author

Doukky, Rami, Donenberg, Merrick J., Parker, Jeremy, Kaplan, Jonathan, Travers, Chad, Soble, Jeffrey S., Sattar, Payman, Krishnan, Kousik, Madias, Christopher, Tracy, Melissa, and Feinstein, Steven B.

Subjects
ATRIAL fibrillation, CARDIOVASCULAR diseases, CONFIDENCE, ELECTRIC countershock, THROMBOSIS, TRANSESOPHAGEAL echocardiography, DECISION making in clinical medicine, CONTRAST media, RETROSPECTIVE studies, PHYSICIANS' attitudes, LEFT heart atrium, THERAPEUTICS
Abstract

Background: The value of ultrasound enhancing agents (UEA) in patients undergoing transesophageal echocardiography (TEE) for the exclusion of left atrial appendage (LAA) thrombi prior to direct current cardioversion (DCCV) is evolving. Methods: We retrospectively identified 88 consecutive TEEs, where a commercial UEA was used during LAA interrogation. De‐identified non‐enhanced (pre‐UEA) and enhanced cine loop images (post‐UEA) from the same subjects were randomly reviewed by four expert readers in a blinded fashion. Results: In 33% of the cases, UEA use was associated with a statistically insignificant improvement in physician confidence (scale, 0‐3) in determining the presence or absence of a LAA thrombus (P = 0.071). In instances where non‐enhanced images yielded an uncertain interpretation or when the left atrium contained spontaneous echo contrast (SEC), UEA use was associated with an improvement in interpretive confidence in 49% (P < 0.001) and 41% of the cases (P = 0.001), respectively. Overall, the absolute rate of hypothetical decision to proceed with DCCV rose by 9% with the application of UEA (P = 0.004). In instances where non‐enhanced images were interpreted with limited confidence or when SEC was present, there were absolute increases of 16% (P < 0.001) and 21% (P < 0.001) in hypothetical procession to DCCV, respectively. In cases of a combination of limited interpretive confidence and SEC, UEA use was associated with a 29% absolute increase in the rate of procession to DCCV (P < 0.001). Conclusions: In patients undergoing TEE interrogation of the LAA, the use of UEA is associated with an increase in the level of interpretive confidence and higher rates of theoretical procession to DCCV. [ABSTRACT FROM AUTHOR]

Published
2019
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22. Therapeutic ultrasound: Increased HDL-Cholesterol following infusions of acoustic microspheres and apolipoprotein A-I plasmids

Author

Castle, Jason W., primary, Kent, Kevin P., additional, Fan, Ying, additional, Wallace, Kirk D., additional, Davis, Cynthia E.L., additional, Roberts, Jeannette C., additional, Marino, Michael E., additional, Thomenius, Kai E., additional, Lim, Hae W., additional, Coles, Eric, additional, Davidson, Michael H., additional, Feinstein, Steven B., additional, and DeMaria, Anthony, additional

Published
2015
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23. Abstract 16463: Soluble Urokinase Plasminogen Activator Receptor Levels Rise in Response to Cardiotoxic Chemotherapy Independent of Global Longitudinal Strain

Author

Devanesan, Maria, Atallah, Issam, Gaddam, Hannah, Jones, Kelli, Samelko, Beata, Beck, Todd, Zhang, Yanyu, Wei, Changli, Blatter, Lothar A, Feinstein, Steven B, Reiser, Jochen, Banach, Kathrin, Hayek, Salim, and Okwuosa, Tochi M

Abstract

Introduction:Soluble urokinase-type plasminogen activator receptor (suPAR) is a marker of chronic immune activation and a strong predictor of cardiovascular outcomes, including heart failure. Determining if suPAR levels are affected by cardiotoxic chemotherapy is the first step towards evaluating its potential usefulness in predicting the risk of cardiotoxicity.Methods:We measured serum suPAR, troponin-I, NT-proBNP, and high-sensitivity C-reactive protein (hs-CRP) in 23 adult women <65 years of age (mean age 49 years, 30% African American), without baseline cardiac history and receiving 4 cycles of doxorubicin (DOX) for newly diagnosed ER/PR positive, HER2 negative, non-metastatic breast cancer. Biomarkers were assessed prior to, post DOX cycle #2, cycle #4 and 3, 6, 12 months post-DOX. Speckle tracking echo was performed concurrently for global longitudinal strain (GLS) analysis. We used mixed modeling for repeated measures to examine the change in biomarkers and GLS.Results:Pre-treatment levels of suPAR was 2.76 (2.3 -2.7 ng/mL), NT-proBNP: 30.5 (14.7 -90.1 pg/mL), hs-CRP: 3.5 (1.5 -10.1 mg/L ), troponin: <0.01 ng/mL and mean GLS: -20%. Post DOX cycle #4, median suPAR and NT-proBNP levels were 22% and 310% higher than baseline respectively (p<0.01), while there was no significant change in hs-CRP, troponin-I or GLS. At 6 months post-DOX, suPAR returned to baseline levels, while NT-proBNP remained elevated (p<0.01). By median follow-up of 14 months, none of the subjects showed clinical or echocardiographic signs of cardiotoxicity.Conclusion:Serum suPAR and NT-proBNP levels increased in response to DOX treatment in breast cancer patients in the absence of significant changes in GLS or clinical signs of cardiotoxicity. NT-proBNP is a proven marker of cardiotoxicity; however suPAR levels correlated with clinically absent signs of cardiotoxicity, and may serve as a promising novel biomarker for subclinical chemotherapy-related cardiotoxicity.

Published
2019
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24. Carotid intraplaque neovascularization predicts coronary artery disease and cardiovascular events.

Author

Mantella LE, Colledanchise KN, Hétu MF, Feinstein SB, Abunassar J, and Johri AM

Subjects
Aged, Carotid Artery Diseases diagnostic imaging, Contrast Media, Coronary Angiography, Coronary Artery Disease diagnostic imaging, Female, Fluorocarbons, Humans, Male, Middle Aged, Neovascularization, Pathologic diagnostic imaging, Plaque, Atherosclerotic diagnostic imaging, Prospective Studies, Risk Assessment, Ultrasonography, Carotid Artery Diseases pathology, Coronary Artery Disease pathology, Neovascularization, Pathologic pathology, Plaque, Atherosclerotic pathology
Abstract

Aims: It is thought that the majority of cardiovascular (CV) events are caused by vulnerable plaque. Such lesions are rupture prone, in part due to neovascularization. It is postulated that plaque vulnerability may be a systemic process and that vulnerable lesions may co-exist at multiple sites in the vascular bed. This study sought to examine whether carotid plaque vulnerability, characterized by contrast-enhanced ultrasound (CEUS)-assessed intraplaque neovascularization (IPN), was associated with significant coronary artery disease (CAD) and future CV events., Methods and Results: We investigated carotid IPN using carotid CEUS in 459 consecutive stable patients referred for coronary angiography. IPN was graded based on the presence and location of microbubbles within each plaque (0, not visible; 1, peri-adventitial; and 2, plaque core). The grades of each plaque were averaged to obtain an overall score per patient. Coronary plaque severity and complexity was also determined angiographically. Patients were followed for 30 days following their angiogram. This study found that a higher CEUS-assessed carotid IPN score was associated with significant CAD (≥50% stenosis) (1.8 ± 0.4 vs. 0.5 ± 0.6, P < 0.0001) and greater complexity of coronary lesions (1.7 ± 0.5 vs. 1.3 ± 0.8, P < 0.0001). Furthermore, an IPN score ≥1.25 could predict significant CAD with a high sensitivity (92%) and specificity (89%). The Kaplan-Meier analysis demonstrated a significantly higher proportion of participants having CV events with an IPN score ≥1.25 (P = 0.004)., Conclusion: Carotid plaque neovascularization was found to be predictive of significant and complex CAD and future CV events. CEUS-assessed carotid IPN is a clinically useful tool for CV risk stratification in high-risk cardiac patients., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.)

Published
2019
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