167 results on '"Fauser B."'
Search Results
2. Hormonen
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Fauser, B. C. J. M., de Kloet, E. R., Laven, J. S. E., Lips, P., Michels, R. P. J., Pereira, A. M., Sitsen, J. M. A., Wiersinga, W. M., Cohen, A. F., editor, Danhof, M., editor, de Greef, H. J. M. M., editor, Ijzerman, A. P., editor, Kenter, M. J. H., editor, Schellens, J. H. M., editor, and Sitsen, J. M. A., editor
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- 2017
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3. PMON238 Bone mineral density in middle-aged women with reproductive disorders
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van Zwol - Janssens, Charissa, primary, Hage, Aglaia, additional, van der Ham, K, additional, Velthuis, B K, additional, Budde, R P J, additional, Koster, M P H, additional, Louwers, Y V, additional, Franx, A, additional, Fauser, B C J M, additional, Boersma, E, additional, and Laven, J S E, additional
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- 2022
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4. O-047 Can ovarian response be predicted and why would you want to know?
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Fauser, B C J M, primary
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- 2022
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5. Vrouwenziekten
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Fauser, B. C. J. M., primary and Helmerhorst, T. J. M., additional
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- 2016
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6. Outcome After Thrombectomy and Intravenous Thrombolysis in Patients With Acute Ischemic Stroke: A Prospective Observational Study
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Minnerup, Jens, Wersching, Heike, Teuber, Anja, Wellmann, Jürgen, Eyding, Jens, Weber, Ralph, Reimann, Gernot, Weber, Werner, Krause, Lars Udo, Kurth, Tobias, Berger, Klaus, Homberg, V., Petrovitch, A., Heuser, L., Mönnigs, P., Krogias, C., Wallner, B., Hennigs, S., Ahlers, A., Sahl, H., Ranft, A., Dobis, C., Brassel, F., Nolden-Koch, M., Schmitt, H., Chapot, R., Nordmeyer, H., Schlamann, M., Weimar, C., Busch, F., Busch, E.W., Sigges, E., Ruf, H., Wohlfahrt, K., Karatschai, R., Klein, B., Höhle, T., Haass, A., Nasreldein, A., Büchele, B., Gahn, G., Sterker, M., Hantel, T., Krämer, C., Henningsen, H., Adelt, I., König, M., Schmidt, C., Hofmann, A., Niederstadt, T., Unrath, M., Rehfeldt, T., Fauser, B., Pfeiffer, A., Lowens, S., Stögbauer, F., Staudacher, T., Erdmann, P., Grotemeyer, K.H., Spüntrup, E., Bücke, P., Wienecke, P., Faiss, J., Wolzik-Großmann, M., Brune, N., Isenmann, S., Thomas, C., and Mucha, D.
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- 2016
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7. Coronary artery calcification in middle-aged women with premature ovarian insufficiency
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Gunning, M.N., Meun, C., Rijn, B.B. van, Maas, A.H.E.M., Benschop, L., Franx, A., Boersma, E., Budde, R.P.J., Appelman, Y., Lambalk, C.B., Eijkemans, M.J.C., Velthuis, B.K., Laven, J.S.E., Fauser, B.C.J.M., Baart, S., Brouwers, L., Budde, R., Cannegieter, S., Dam, V., Daan, N., Eijkemans, R., Fauser, B., Ferrari, M., Groot, C. de, Gunning, M., Hoek, A., Koffijberg, E., Koster, W., Kruit, M., Lagerweij, G., Lambalk, N., Laven, J., Linstra, K., Lugt, A. van der, Maas, A., Brink, A.M. van den, Middeldorp, S., Moons, K., Rijn, B. van, Lennep, J.R. van, Roos-Hesselink, J., Scheres, L., Schouw, Y. van der, Steegers, E., Steegers, R., Terwindt, G., Velthuis, B., Wermer, M., Zick, B., Zoet, G., CREW Consortium, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, ARD - Amsterdam Reproduction and Development, Obstetrics & Gynecology, Cardiology, Radiology & Nuclear Medicine, Internal Medicine, ACS - Atherosclerosis & ischemic syndromes, Amsterdam Reproduction & Development (AR&D), Obstetrics and gynaecology, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, ACS - Microcirculation, Reproductive Origins of Adult Health and Disease (ROAHD), and Health Technology & Services Research
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Heart disease ,Endocrinology, Diabetes and Metabolism ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,UT-Hybrid-D ,Primary Ovarian Insufficiency ,GUIDELINES ,Coronary artery disease ,0302 clinical medicine ,Endocrinology ,reproductive disorder ,Medicine ,RISK ,education.field_of_study ,cardiovascular ,POI ,Calcinosis ,Middle Aged ,Coronary Vessels ,Menopause ,risk factor ,CARDIOVASCULAR-DISEASE ,030220 oncology & carcinogenesis ,Cohort ,Female ,STROKE ,MENOPAUSE ,medicine.medical_specialty ,Population ,SOCIETY ,030209 endocrinology & metabolism ,HEART-DISEASE ,PROFILE ,Premature ovarian insufficiency ,CALCIUM ,coronary artery calcium score ,03 medical and health sciences ,Internal medicine ,Diabetes mellitus ,Humans ,COMPUTED-TOMOGRAPHY ,cardiovascular diseases ,Risk factor ,education ,Aged ,business.industry ,nutritional and metabolic diseases ,medicine.disease ,22/4 OA procedure ,Case-Control Studies ,business - Abstract
Item does not contain fulltext OBJECTIVE: Women with premature ovarian insufficiency (POI) enter menopause before age 40. Early menopause was associated with increased risk for coronary artery disease (CAD), death from cardiovascular disease and all-cause mortality. We compared the prevalence of CAD between middle-aged women on average 10 years following the initial POI diagnosis, with a population-based cohort. DESIGN: Cross-sectional case-control study. PARTICIPANTS: Women from two Dutch University Medical Centers above 45 years of age previously diagnosed with POI (n = 98) were selected and compared with age- and race-matched controls from the Multi-Ethnic Study of Atherosclerosis (MESA). MEASUREMENTS: The primary outcome was detectable coronary artery calcium (CAC) determined by coronary computed tomography (CCT). RESULTS: Women with POI had significantly higher blood pressure, cholesterol and glucose, despite lower BMI compared to controls. Similar proportions of detectable CAC (CAC score >0 Agatston Units) were observed in women with POI and controls (POI n = 16 (16%), controls n = 52 (18%), P = 0.40 and Padj = 0.93). In women with POI separately, we were not able to identify associations between CVD risk factors and CAC. The following CVD risk factors in controls were positively associated with CAC: age, diabetes mellitus, hypertension and LDL cholesterol. HRT use was negatively associated with CAC in controls. CONCLUSIONS: The presence of CAC did not differ significantly in women with POI around 50 years of age, compared to an age- and race-matched control group. We observe no increased calcified coronary disease in POI patients, despite the presence of unfavourable cardiovascular risk factors in these women.
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- 2019
8. O-114 Improved safety and efficiency of individualised versus conventional gonadotropin dosing for ovarian stimulation in IVF/ICSI: an individual patient meta-analysis (IPD-MA)
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Janse, F, primary, Eijkemans, M, additional, and Fauser, B, additional
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- 2021
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9. Fair allocation of cryopreserved donor oocytes: Towards an accountable process
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Global Public Health & Bioethics, Bioethics & Health Humanities, Circulatory Health, JC onderzoeksprogramma Methodology, MS VPG/Gynaecologie, Child Health, Cancer, Medical Humanities Onderzoek Team 2, Regenerative Medicine and Stem Cells, Kool, E. M., Van Der Graaf, R., Bos, A. M.E., Fauser, B. C.J.M., Bredenoord, A. L., Global Public Health & Bioethics, Bioethics & Health Humanities, Circulatory Health, JC onderzoeksprogramma Methodology, MS VPG/Gynaecologie, Child Health, Cancer, Medical Humanities Onderzoek Team 2, Regenerative Medicine and Stem Cells, Kool, E. M., Van Der Graaf, R., Bos, A. M.E., Fauser, B. C.J.M., and Bredenoord, A. L.
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- 2021
10. The cardiovascular risk profile of middle-aged women with polycystic ovary syndrome
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Meun, C., Gunning, M.N., Louwers, Y.V., Peters, H., Roos-Hesselink, J., Lennep, J.R. van, Ochoa, O.L.R., Appelman, Y., Lambalk, N., Boersma, E., Kavousi, M., Fauser, B.C.J.M., Laven, J.S.E., Baart, S., Benschop, L., Brouwers, L., Budde, R., Cannegieter, S., Dam, V., Eijkemans, R., Fauser, B., Ferrari, M., Franx, A., Groot, C. de, Gunning, M., Hoek, A., Koffijberg, E., Koster, W., Kruit, M., Lagerweij, G., Laven, J., Linstra, K., Lugt, A. van der, Maas, A., Brink, A.M. van den, Middeldorp, S., Moons, K.G.M., Rijn, B. van, Scheres, L., Schouw, Y.T. van der, Steegers, E., Steegers, R., Terwindt, G., Velthuis, B., Wermer, M., Zick, B., Zoet, G., CREW Consortium, Health Technology & Services Research, Obstetrics & Gynecology, Cardiology, Internal Medicine, Epidemiology, Reproductive Origins of Adult Health and Disease (ROAHD), ACS - Atherosclerosis & ischemic syndromes, Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), ACS - Microcirculation, ACS - Pulmonary hypertension & thrombosis, ARD - Amsterdam Reproduction and Development, Vascular Medicine, and Graduate School
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endocrine system diseases ,PREDICTION ,Endocrinology, Diabetes and Metabolism ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,UT-Hybrid-D ,Carotid Intima-Media Thickness ,INTIMA-MEDIA THICKNESS ,DISEASE ,0302 clinical medicine ,Endocrinology ,Risk Factors ,cardiovascular disease (7) ,PCOS ,Insulin ,Netherlands ,ASSOCIATIONS ,Metabolic Syndrome ,education.field_of_study ,Framingham Risk Score ,Reproduction ,Age Factors ,Middle Aged ,Lipids ,Polycystic ovary ,PREVALENCE ,Diabetes and Metabolism ,NATIONWIDE POPULATION ,Cardiovascular Diseases ,030220 oncology & carcinogenesis ,Original Article ,Female ,HEALTH ,medicine.medical_specialty ,MENOPAUSE ,Waist ,Population ,030209 endocrinology & metabolism ,03 medical and health sciences ,Internal medicine ,Journal Article ,medicine ,Humans ,Body Weights and Measures ,education ,business.industry ,nutritional and metabolic diseases ,Original Articles ,Anthropometry ,medicine.disease ,Cross-Sectional Studies ,Intima-media thickness ,MYOCARDIAL-INFARCTION ,Heart Disease Risk Factors ,polycystic ovary syndrome ,Case-Control Studies ,Metabolic syndrome ,business ,Body mass index - Abstract
Contains fulltext : 220851.pdf (Publisher’s version ) (Open Access) OBJECTIVES: Contradictory results have been reported regarding the association between polycystic ovary syndrome (PCOS) and cardiovascular disease (CVD). We assessed the cardiometabolic phenotype and prevalence of CVD in middle-aged women with PCOS, compared with age-matched controls from the general population, and estimated 10-year CVD risk and cardiovascular health score. DESIGN: A cross-sectional study. PARTICIPANTS: 200 women aged >45 with PCOS, and 200 age-matched controls. MEASUREMENTS: Anthropometrics, insulin, lipid levels, prevalence of metabolic syndrome and type II diabetes. Ten-year Framingham risk score and the cardiovascular health score were calculated, and carotid intima-media thickness (cIMT) was measured. RESULTS: Mean age was 50.5 years (SD = 5.5) in women with PCOS and 51.0 years (SD = 5.2) in controls. Increased waist circumference, body mass index and hypertension were more often observed in women with PCOS (P < .001). In women with PCOS, the prevalence of type II diabetes and metabolic syndrome was not significantly increased and lipid levels were not different from controls. cIMT was lower in women with PCOS (P < .001). Calculated cardiovascular health and 10-year CVD risk were similar in women with PCOS and controls. CONCLUSIONS: Middle-aged women with PCOS exhibit only a moderately unfavourable cardiometabolic profile compared to age-matched controls, even though they present with an increased BMI and waist circumference. Furthermore, we found no evidence for increased (10-year) CVD risk or more severe atherosclerosis compared with controls from the general population. Long-term follow-up of women with PCOS is necessary to provide a definitive answer concerning long-term risk for CVD.
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- 2020
11. Context-based infertility care
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Macklon, N. S., Fauser, B. C. J. M., Macklon, N. S., and Fauser, B. C. J. M.
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- 2020
12. Context-based infertility care
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MS VPG/Gynaecologie, Macklon, N. S., Fauser, B. C. J. M., MS VPG/Gynaecologie, Macklon, N. S., and Fauser, B. C. J. M.
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- 2020
13. Cardiometabolic health in offspring of women with PCOS compared to healthy controls: a systematic review and individual participant data meta-analysis
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Gunning, MN, Petermann, TS, Crisosto, N, van Rijn, Bas, de Wilde, MA, Christ, JP, Uiterwaal, C, Jager, W, Eijkemans, MJC, Kunselman, AR, Legro, RS, Fauser, B, Gunning, MN, Petermann, TS, Crisosto, N, van Rijn, Bas, de Wilde, MA, Christ, JP, Uiterwaal, C, Jager, W, Eijkemans, MJC, Kunselman, AR, Legro, RS, and Fauser, B
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- 2020
14. Fair allocation of cryopreserved donor oocytes: towards an accountable process
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Kool, E M, primary, van der Graaf, R, additional, Bos, A M E, additional, Fauser, B C J M, additional, and Bredenoord, A L, additional
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- 2021
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15. The ethics of embryo donation: what are the moral similarities and differences of surplus embryo donation and double gamete donation?
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Huele, E H, primary, Kool, E M, additional, Bos, A M E, additional, Fauser, B C J M, additional, and Bredenoord, A L, additional
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- 2020
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16. Chronic risk conditions and pregnancy
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Spaanderman, Marc E. A., Bijma, Hilmar, Duvekot, Johannes J., van Pampus, Marielle G., van Leeuwen, Elisabeth, Cornette, Jerome M. J., Lely, Titia A. T., Peeters, Louis L. H., Ghossein-Doha, Chahinda, Steegers, E. A. P., Fauser, B. C. J. M., Hilders, C. G. J. M., Jaddoe, V. W. V., Massuger, L. F. A. G., van der Post, J. A. M., Schoenmakers, S., Amsterdam Reproduction & Development, and Obstetrics and Gynaecology
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- 2019
17. Associations of preconception Body Mass Index in women with PCOS and BMI and blood pressure of their offspring
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Gunning, M N, van Rijn, B B, Bekker, M N, de Wilde, M A, Eijkemans, M J C, Fauser, B C J M, Gunning, M N, van Rijn, B B, Bekker, M N, de Wilde, M A, Eijkemans, M J C, and Fauser, B C J M
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- 2019
18. What is the prognosis for a live birth after unexplained recurrent implantation failure following IVF/ICSI?
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Koot, Y E M, Hviid Saxtorph, M, Goddijn, M, de Bever, S, Eijkemans, M J C, Wely, M V, van der Veen, F, Fauser, B C J M, Macklon, N S, Koot, Y E M, Hviid Saxtorph, M, Goddijn, M, de Bever, S, Eijkemans, M J C, Wely, M V, van der Veen, F, Fauser, B C J M, and Macklon, N S
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- 2019
19. Stakeholders views on the ethical aspects of oocyte banking for third-party assisted reproduction : a qualitative interview study with donors, recipients and professionals
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Kool, E M, van der Graaf, R, Bos, A M E, Pieters, J J P M, Custers, I M, Fauser, B C J M, Bredenoord, A L, Kool, E M, van der Graaf, R, Bos, A M E, Pieters, J J P M, Custers, I M, Fauser, B C J M, and Bredenoord, A L
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- 2019
20. Associations of preconception Body Mass Index in women with PCOS and BMI and blood pressure of their offspring
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MS VPG/Gynaecologie, Child Health, MS Verloskunde, Arts-assistenten DV&B, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Gunning, M N, van Rijn, B B, Bekker, M N, de Wilde, M A, Eijkemans, M J C, Fauser, B C J M, MS VPG/Gynaecologie, Child Health, MS Verloskunde, Arts-assistenten DV&B, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Gunning, M N, van Rijn, B B, Bekker, M N, de Wilde, M A, Eijkemans, M J C, and Fauser, B C J M
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- 2019
21. What is the prognosis for a live birth after unexplained recurrent implantation failure following IVF/ICSI?
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MS VPG/Gynaecologie, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Koot, Y E M, Hviid Saxtorph, M, Goddijn, M, de Bever, S, Eijkemans, M J C, Wely, M V, van der Veen, F, Fauser, B C J M, Macklon, N S, MS VPG/Gynaecologie, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Koot, Y E M, Hviid Saxtorph, M, Goddijn, M, de Bever, S, Eijkemans, M J C, Wely, M V, van der Veen, F, Fauser, B C J M, and Macklon, N S
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- 2019
22. Stakeholders views on the ethical aspects of oocyte banking for third-party assisted reproduction: a qualitative interview study with donors, recipients and professionals
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Medical Humanities Onderzoek Team 2, Medical Humanities Onderzoek Team 1, Circulatory Health, JC onderzoeksprogramma Methodologie, MS VPG/Gynaecologie, Child Health, Cancer, Zorgeenheid Plastische Chirurgie Medisch, Regenerative Medicine and Stem Cells, Kool, E M, van der Graaf, R, Bos, A M E, Pieters, J J P M, Custers, I M, Fauser, B C J M, Bredenoord, A L, Medical Humanities Onderzoek Team 2, Medical Humanities Onderzoek Team 1, Circulatory Health, JC onderzoeksprogramma Methodologie, MS VPG/Gynaecologie, Child Health, Cancer, Zorgeenheid Plastische Chirurgie Medisch, Regenerative Medicine and Stem Cells, Kool, E M, van der Graaf, R, Bos, A M E, Pieters, J J P M, Custers, I M, Fauser, B C J M, and Bredenoord, A L
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- 2019
23. Erratum: Letter to the Editor: Individualized FSH dosing improves safety and reduces iatrogenic poor response while maintaining live-birth rates (Hum Reprod (2018) 33 (985-986)
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La Marca, A., Blockeel, C., Bosch, E., Fanchin, R., Fatemi, H. M., Fauser, B. C., Garcia-Velasco, J. A., Humaidan, P., Tarlatzis, B. C., and Nelson, S. M.
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- 2018
24. Letter to the Editor: Individualized FSH dosing improves safety and reduces iatrogenic poor response while maintaining live-birth rates (vol 33, pg 985, 2018)
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La Marca A, Blockeel C, Bosch E, Fanchin R, Fatemi H, Fauser B, Garcia-Velasco J, Humaidan P, Tarlatzis B, and Nelson S
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- 2018
25. Individualized FSH dosing improves safety and reduces iatrogenic poor response while maintaining live-birth rates
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La Marca A, Blockeel C, Bosch E, Fanchin R, Fatemi H, Fauser B, Garcia-Velasco J, Humaidan P, Tarlatzis B, and Nelson S
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- 2018
26. What is the prognosis for a live birth after unexplained recurrent implantation failure following IVF/ICSI?
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Koot, Y E M, primary, Hviid Saxtorph, M, additional, Goddijn, M, additional, de Bever, S, additional, Eijkemans, M J C, additional, Wely, M v, additional, van der Veen, F, additional, Fauser, B C J M, additional, and Macklon, N S, additional
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- 2019
- Full Text
- View/download PDF
27. Associations of preconception Body Mass Index in women with PCOS and BMI and blood pressure of their offspring
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Gunning, M. N., primary, van Rijn, B. B., additional, Bekker, M. N., additional, de Wilde, M. A., additional, Eijkemans, M. J. C., additional, and Fauser, B. C. J. M., additional
- Published
- 2019
- Full Text
- View/download PDF
28. Stakeholders views on the ethical aspects of oocyte banking for third-party assisted reproduction: a qualitative interview study with donors, recipients and professionals
- Author
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Kool, E M, primary, van der Graaf, R, additional, Bos, A M E, additional, Pieters, J J P M, additional, Custers, I M, additional, Fauser, B C J M, additional, and Bredenoord, A L, additional
- Published
- 2019
- Full Text
- View/download PDF
29. Ethics of oocyte banking for third-party assisted reproduction : a systematic review
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Kool, E M, Bos, A M E, van der Graaf, R, Fauser, B C J M, Bredenoord, A L, Kool, E M, Bos, A M E, van der Graaf, R, Fauser, B C J M, and Bredenoord, A L
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- 2018
30. Prevalence of Subclinical Coronary Artery Disease Assessed by Coronary Computed Tomography Angiography in 45- to 55-Year-Old Women With a History of Preeclampsia
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Zoet, G.A., Benschop, L., Boersma, E., Budde, R.P., Fauser, B., Graaf, Y. van der, Groot, C.J. de, Maas, A.H.E.M., Roeters van Lennep, J.E., Steegers, E.A., Visseren, F.L., Rijn, B.B. van, Velthuis, B.K., Franx, A., Zoet, G.A., Benschop, L., Boersma, E., Budde, R.P., Fauser, B., Graaf, Y. van der, Groot, C.J. de, Maas, A.H.E.M., Roeters van Lennep, J.E., Steegers, E.A., Visseren, F.L., Rijn, B.B. van, Velthuis, B.K., and Franx, A.
- Abstract
Item does not contain fulltext
- Published
- 2018
31. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome.
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Tapanainen J.S., Witchel S., Woolcock J., Yildiz B.O., Rombauts L., Mol B.W., Mansfield D., Joham A., Teede H.J., Misso M.L., Costello M.F., Dokras A., Laven J., Moran L., Piltonen T., Norman R.J., Andersen M., Azziz R., Balen A., Baye E., Boyle J., Brennan L., Broekmans F., Dabadghao P., Devoto L., Dewailly D., Downes L., Fauser B., Franks S., Garad R.M., Gibson-Helm M., Harrison C., Hart R., Hawkes R., Hirschberg A., Hoeger K., Hohmann F., Hohmann H., Vet D., Hutchison S., Johnson L., Jordan C., Kulkarni J., Legro R.S., Li R., Lujan M., Malhotra J., Marsh K., McAllister V., Mocanu E., Ng E., Oberfield S., Ottey S., Pena A., Qiao J., Redman L., Rodgers R., Romualdi D., Shah D., Speight J., Spritzer P.M., Stener-Victorin E., Stepto N., Tassone E.C., Thangaratinam S., Thondan M., Tzeng C.-R., van der Spuy Z., Vanky E., Vogiatzi M., Wan A., Wijeyaratne C., Tapanainen J.S., Witchel S., Woolcock J., Yildiz B.O., Rombauts L., Mol B.W., Mansfield D., Joham A., Teede H.J., Misso M.L., Costello M.F., Dokras A., Laven J., Moran L., Piltonen T., Norman R.J., Andersen M., Azziz R., Balen A., Baye E., Boyle J., Brennan L., Broekmans F., Dabadghao P., Devoto L., Dewailly D., Downes L., Fauser B., Franks S., Garad R.M., Gibson-Helm M., Harrison C., Hart R., Hawkes R., Hirschberg A., Hoeger K., Hohmann F., Hohmann H., Vet D., Hutchison S., Johnson L., Jordan C., Kulkarni J., Legro R.S., Li R., Lujan M., Malhotra J., Marsh K., McAllister V., Mocanu E., Ng E., Oberfield S., Ottey S., Pena A., Qiao J., Redman L., Rodgers R., Romualdi D., Shah D., Speight J., Spritzer P.M., Stener-Victorin E., Stepto N., Tassone E.C., Thangaratinam S., Thondan M., Tzeng C.-R., van der Spuy Z., Vanky E., Vogiatzi M., Wan A., and Wijeyaratne C.
- Abstract
Study Question: What is the recommended assessment and management of women with polycystic ovary syndrome (PCOS), based on the best available evidence, clinical expertise, and consumer preference?. Summary Answer: International evidence-based guidelines including 166 recommendations and practice points, addressed prioritized questions to promote consistent, evidence-based care and improve the experience and health outcomes of women with PCOS. What is Known Already: Previous guidelines either lacked rigorous evidence-based processes, did not engage consumer and international multidisciplinary perspectives, or were outdated. Diagnosis of PCOS remains controversial and assessment and management are inconsistent. The needs of women with PCOS are not being adequately met and evidence practice gaps persist. Study Design, Size, Duration: International evidence-based guideline development engaged professional societies and consumer organizations with multidisciplinary experts and women with PCOS directly involved at all stages. Appraisal of Guidelines for Research and Evaluation (AGREE) II-compliant processes were followed, with extensive evidence synthesis. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) framework was applied across evidence quality, feasibility, acceptability, cost, implementation and ultimately recommendation strength. Participants/Materials, Setting, Methods: Governance included a six continent international advisory and a project board, five guideline development groups (GDGs), and consumer and translation committees. Extensive health professional and consumer engagement informed guideline scope and priorities. Engaged international society-nominated panels included pediatrics, endocrinology, gynecology, primary care, reproductive endocrinology, obstetrics, psychiatry, psychology, dietetics, exercise physiology, public health and other experts, alongside consumers, project management, evidence synthesis, and translation
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- 2018
32. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome.
- Author
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Malhotra J., Stepto N., Tapanainen J.S., Tassone E.C., Thangaratinam S., Thondan M., Tzeng C.-R., Van Der Spuy Z., Vanky E., Vogiatzi M., Wan A., Wijeyaratne C., Witchel S., Woolcock J., Yildiz B.O., Qiao J., Redman L., Rodgers R., Romualdi D., Shah D., Speight J., Spritzer P.M., Stener-Victorin E., Teede H.J., Rombauts L., Moran L., Mol B.W., Mansfield D., Joham A., Misso M.L., Costello M.F., Dokras A., Laven J., Piltonen T., Norman R.J., Andersen M., Azziz R., Balen A., Baye E., Boyle J., Brennan L., Broekmans F., Dabadghao P., Devoto L., Dewailly D., Downes L., Fauser B., Franks S., Garad R.M., Gibson-Helm M., Harrison C., Hart R., Hawkes R., Hirschberg A., Hoeger K., Hohmann F., Hutchison S., Johnson L., Jordan C., Kulkarni J., Legro R.S., Li R., Lujan M., Marsh K., McAllister V., Mocanu E., Ng E., Oberfield S., Ottey S., Pena A., Malhotra J., Stepto N., Tapanainen J.S., Tassone E.C., Thangaratinam S., Thondan M., Tzeng C.-R., Van Der Spuy Z., Vanky E., Vogiatzi M., Wan A., Wijeyaratne C., Witchel S., Woolcock J., Yildiz B.O., Qiao J., Redman L., Rodgers R., Romualdi D., Shah D., Speight J., Spritzer P.M., Stener-Victorin E., Teede H.J., Rombauts L., Moran L., Mol B.W., Mansfield D., Joham A., Misso M.L., Costello M.F., Dokras A., Laven J., Piltonen T., Norman R.J., Andersen M., Azziz R., Balen A., Baye E., Boyle J., Brennan L., Broekmans F., Dabadghao P., Devoto L., Dewailly D., Downes L., Fauser B., Franks S., Garad R.M., Gibson-Helm M., Harrison C., Hart R., Hawkes R., Hirschberg A., Hoeger K., Hohmann F., Hutchison S., Johnson L., Jordan C., Kulkarni J., Legro R.S., Li R., Lujan M., Marsh K., McAllister V., Mocanu E., Ng E., Oberfield S., Ottey S., and Pena A.
- Abstract
STUDY QUESTION: What is the recommended assessment and management of women with polycystic ovary syndrome (PCOS), based on the best available evidence, clinical expertise and consumer preference? SUMMARY ANSWER: International evidence-based guidelines, including 166 recommendations and practice points, addressed prioritized questions to promote consistent, evidence-based care and improve the experience and health outcomes of women with PCOS. WHAT IS KNOWN ALREADY: Previous guidelines either lacked rigorous evidence-based processes, did not engage consumer and international multidisciplinary perspectives, or were outdated. Diagnosis of PCOS remains controversial, and assessment and management are inconsistent. The needs of women with PCOS are not being adequately met and evidence practice gaps persist. STUDY DESIGN, SIZE, DURATION: International evidence-based guideline development engaged professional societies and consumer organizations with multidisciplinary experts and women with PCOS directly involved at all stages. Appraisal of Guidelines for Research and Evaluation (AGREE) II-compliant processes were followed, with extensive evidence synthesis. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework was applied across evidence quality, feasibility, acceptability, cost, implementation and ultimately recommendation strength. PARTICIPANTS/MATERIALS, SETTING, METHODS: Governance included a six continent international advisory and a project board, five guideline development groups, and consumer and translation committees. Extensive health professional and consumer engagement informed guideline scope and priorities. Engaged international society-nominated panels included pediatrics, endocrinology, gynecology, primary care, reproductive endocrinology, obstetrics, psychiatry, psychology, dietetics, exercise physiology, public health and other experts, alongside consumers, project management, evidence synthesis and translation experts.
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- 2018
33. Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria
- Author
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Day, F. (Felix), Karaderi, T. (Tugce), Jones, M. R. (Michelle R.), Meun, C. (Cindy), He, C. (Chunyan), Drong, A. (Alex), Kraft, P. (Peter), Lin, N. (Nan), Huang, H. (Hongyan), Broer, L. (Linda), Magi, R. (Reedik), Saxena, R. (Richa), Laisk, T. (Triin), Urbanek, M. (Margrit), Hayes, M. G. (M. Geoffrey), Thorleifsson, G. (Gudmar), Fernandez-Tajes, J. (Juan), Mahajan, A. (Anubha), Mullin, B. H. (Benjamin H.), Stuckey, B. G. (Bronwyn G. A.), Spector, T. D. (Timothy D.), Wilson, S. G. (Scott G.), Goodarzi, M. O. (Mark O.), Davis, L. (Lea), Obermayer-Pietsch, B. (Barbara), Uitterlinden, A. G. (Andre G.), Anttila, V. (Verneri), Neale, B. M. (Benjamin M.), Järvelin, M.-R. (Marjo-Riitta), Fauser, B. (Bart), Kowalska, I. (Irina), Visser, J. A. (Jenny A.), Andersen, M. (Marianne), Ong, K. (Ken), Stener-Victorin, E. (Elisabet), Ehrmann, D. (David), Legro, R. S. (Richard S.), Salumets, A. (Andres), McCarthy, M. I. (Mark I.), Morin-Papunen, L. (Laure), Thorsteinsdottir, U. (Unnur), Stefansson, K. (Kari), Styrkarsdottir, U. (Unnur), Perry, J. R. (John R. B.), Dunaif, A. (Andrea), Laven, J. (Joop), Franks, S. (Steve), Lindgren, C. M. (Cecilia M.), Welt, C. K. (Corrine K.), Day, F. (Felix), Karaderi, T. (Tugce), Jones, M. R. (Michelle R.), Meun, C. (Cindy), He, C. (Chunyan), Drong, A. (Alex), Kraft, P. (Peter), Lin, N. (Nan), Huang, H. (Hongyan), Broer, L. (Linda), Magi, R. (Reedik), Saxena, R. (Richa), Laisk, T. (Triin), Urbanek, M. (Margrit), Hayes, M. G. (M. Geoffrey), Thorleifsson, G. (Gudmar), Fernandez-Tajes, J. (Juan), Mahajan, A. (Anubha), Mullin, B. H. (Benjamin H.), Stuckey, B. G. (Bronwyn G. A.), Spector, T. D. (Timothy D.), Wilson, S. G. (Scott G.), Goodarzi, M. O. (Mark O.), Davis, L. (Lea), Obermayer-Pietsch, B. (Barbara), Uitterlinden, A. G. (Andre G.), Anttila, V. (Verneri), Neale, B. M. (Benjamin M.), Järvelin, M.-R. (Marjo-Riitta), Fauser, B. (Bart), Kowalska, I. (Irina), Visser, J. A. (Jenny A.), Andersen, M. (Marianne), Ong, K. (Ken), Stener-Victorin, E. (Elisabet), Ehrmann, D. (David), Legro, R. S. (Richard S.), Salumets, A. (Andres), McCarthy, M. I. (Mark I.), Morin-Papunen, L. (Laure), Thorsteinsdottir, U. (Unnur), Stefansson, K. (Kari), Styrkarsdottir, U. (Unnur), Perry, J. R. (John R. B.), Dunaif, A. (Andrea), Laven, J. (Joop), Franks, S. (Steve), Lindgren, C. M. (Cecilia M.), and Welt, C. K. (Corrine K.)
- Abstract
Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have metabolic disturbances including insulin resistance and dysregulation of glucose homeostasis. PCOS is diagnosed with two different sets of diagnostic criteria, resulting in a phenotypic spectrum of PCOS cases. The genetic similarities between cases diagnosed based on the two criteria have been largely unknown. Previous studies in Chinese and European subjects have identified 16 loci associated with risk of PCOS. We report a fixed-effect, inverse-weighted-variance meta-analysis from 10,074 PCOS cases and 103,164 controls of European ancestry and characterisation of PCOS related traits. We identified 3 novel loci (near PLGRKT, ZBTB16 and MAPRE1), and provide replication of 11 previously reported loci. Only one locus differed significantly in its association by diagnostic criteria; otherwise the genetic architecture was similar between PCOS diagnosed by self-report and PCOS diagnosed by NIH or non-NIH Rotterdam criteria across common variants at 13 loci. Identified variants were associated with hyperandrogenism, gonadotropin regulation and testosterone levels in affected women. Linkage disequilibrium score regression analysis revealed genetic correlations with obesity, fasting insulin, type 2 diabetes, lipid levels and coronary artery disease, indicating shared genetic architecture between metabolic traits and PCOS. Mendelian randomization analyses suggested variants associated with body mass index, fasting insulin, menopause timing, depression and male-pattern balding play a causal role in PCOS. The data thus demonstrate 3 novel loci associated with PCOS and similar genetic architecture for all diagnostic criteria. The data also provide the first genetic evidence for a male phenotype for PCOS and a causal link to depression, a previously hypothesized comorbid disease. Thus, the genetics provi
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- 2018
34. Ethics of oocyte banking for third-party assisted reproduction: a systematic review
- Author
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Medical Humanities Onderzoek Team 2, MS VPG/Gynaecologie, Child Health, Cancer, Medical Humanities Onderzoek Team 1, Circulatory Health, JC onderzoeksprogramma Methodologie, Brain, Regenerative Medicine and Stem Cells, Kool, E M, Bos, A M E, van der Graaf, R, Fauser, B C J M, Bredenoord, A L, Medical Humanities Onderzoek Team 2, MS VPG/Gynaecologie, Child Health, Cancer, Medical Humanities Onderzoek Team 1, Circulatory Health, JC onderzoeksprogramma Methodologie, Brain, Regenerative Medicine and Stem Cells, Kool, E M, Bos, A M E, van der Graaf, R, Fauser, B C J M, and Bredenoord, A L
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- 2018
35. Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria
- Author
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Day, F, Karaderi, T, Jones, MR, Meun, Cindy, He, CY, Drong, A, Kraft, P, Lin, N, Huang, HY, Broer, Linda, Magi, R, Saxena, R, Laisk, T, Urbanek, M, Hayes, MG, Thorleifsson, G, Fernandez-Tajes, J, Mahajan, A, Mullin, BH, Stuckey, BGA, Spector, TD, Wilson, SG, Goodarzi, MO, Davis, L, Obermayer-Pietsch, B, Uitterlinden, André, Anttila, V, Neale, BM, Jarvelin, MR, Fauser, B, Kowalska, I, Visser, Jenny, Andersen, M, Ong, K, Stener-Victorin, E, Ehrmann, D, Legro, RS, Salumets, A, McCarthy, MI, Morin-Papunen, L, Thorsteinsdottir, U, Stefansson, K, Styrkarsdottir, U, Perry, JRB, Dunaif, A, Laven, Joop, Franks, S, Lindgren, CM, Welt, CK, Day, F, Karaderi, T, Jones, MR, Meun, Cindy, He, CY, Drong, A, Kraft, P, Lin, N, Huang, HY, Broer, Linda, Magi, R, Saxena, R, Laisk, T, Urbanek, M, Hayes, MG, Thorleifsson, G, Fernandez-Tajes, J, Mahajan, A, Mullin, BH, Stuckey, BGA, Spector, TD, Wilson, SG, Goodarzi, MO, Davis, L, Obermayer-Pietsch, B, Uitterlinden, André, Anttila, V, Neale, BM, Jarvelin, MR, Fauser, B, Kowalska, I, Visser, Jenny, Andersen, M, Ong, K, Stener-Victorin, E, Ehrmann, D, Legro, RS, Salumets, A, McCarthy, MI, Morin-Papunen, L, Thorsteinsdottir, U, Stefansson, K, Styrkarsdottir, U, Perry, JRB, Dunaif, A, Laven, Joop, Franks, S, Lindgren, CM, and Welt, CK
- Published
- 2018
36. Genetic studies of body mass index yield new insights for obesity biology
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Locke, A, Kahali, B, Berndt, S, Justice, A, Pers, T, Day, F, Powell, C, Vedantam, S, Buchkovich, M, Yang, J, Croteau-Chonka, D, Esko, T, Fall, T, Ferreira, T, Gustafsson, S, Kutalik, Z, Luan, J, Magi, R, Randall, J, Winkler, T, Wood, A, Workalemahu, T, Faul, J, Smith, J, Zhao, J, Zhao, W, Chen, J, Fehrmann, R, Hedman, A, Karjalainen, J, Schmidt, E, Absher, D, Amin, N, Anderson, D, Beekman, M, Bolton, J, Bragg-Gresham, J, Buyske, S, Demirkan, A, Deng, G, Ehret, G, Feenstra, B, Feitosa, M, Fischer, K, Goel, A, Gong, J, Jackson, A, Kanoni, S, Kleber, M, Kristiansson, K, Lim, U, Lotay, V, Mangino, M, Leach, I, Medina-Gomez, C, Medland, S, Nalls, M, Palmer, C, Pasko, D, Pechlivanis, S, Peters, M, Prokopenko, I, Shungin, D, Stancakova, A, Strawbridge, R, Sung, Y, Tanaka, T, Teumer, A, Trompet, S, van der Laan, S, van Setten, J, Van Vliet-Ostaptchouk, J, Wang, Z, Yengo, L, Zhang, W, Isaacs, A, Albrecht, E, Arnlov, J, Arscott, G, Attwood, A, Bandinelli, S, Barrett, A, Bas, I, Bellis, C, Bennett, A, Berne, C, Blagieva, R, Bluher, M, Bohringer, S, Bonnycastle, L, Bottcher, Y, Boyd, H, Bruinenberg, M, Caspersen, I, Chen, Y, Clarke, R, Daw, E, de Craen, A, Delgado, G, Dimitriou, M, Doney, A, Eklund, N, Estrada, K, Eury, E, Folkersen, L, Fraser, R, Garcia, M, Geller, F, Giedraitis, V, Gigante, B, Go, A, Golay, A, Goodall, A, Gordon, S, Gorski, M, Grabe, H, Grallert, H, Grammer, T, Grassler, J, Gronberg, H, Groves, C, Gusto, G, Haessler, J, Hall, P, Haller, T, Hallmans, G, Hartman, C, Hassinen, M, Hayward, C, Heard-Costa, N, Helmer, Q, Hengstenberg, C, Holmen, O, Hottenga, J, James, A, Jeff, J, Johansson, A, Jolley, J, Juliusdottir, T, Kinnunen, L, Koenig, W, Koskenvuo, M, Kratzer, W, Laitinen, J, Lamina, C, Leander, K, Lee, N, Lichtner, P, Lind, L, Lindstrom, J, Lo, K, Lobbens, S, Lorbeer, R, Lu, Y, Mach, F, Magnusson, P, Mahajan, A, Mcardle, W, Mclachlan, S, Menni, C, Merger, S, Mihailov, E, Milani, L, Moayyeri, A, Monda, K, Morken, M, Mulas, A, Muller, G, Muller-Nurasyid, M, Musk, A, Nagaraja, R, Nothen, M, Nolte, I, Pilz, S, Rayner, N, Renstrom, F, Rettig, R, Ried, J, Ripke, S, Robertson, N, Rose, L, Sanna, S, Scharnagl, H, Scholtens, S, Schumacher, F, Scott, W, Seufferlein, T, Shi, J, Smith, A, Smolonska, J, Stanton, A, Steinthorsdottir, V, Stirrups, K, Stringham, H, Sundstrom, J, Swertz, M, Swift, A, Syvanen, A, Tan, S, Tayo, B, Thorand, B, Thorleifsson, G, Tyrer, J, Uh, H, Vandenput, L, Verhulst, F, Vermeulen, S, Verweij, N, Vonk, J, Waite, L, Warren, H, Waterworth, D, Weedon, M, Wilkens, L, Willenborg, C, Wilsgaard, T, Wojczynski, M, Wong, A, Wright, A, Zhang, Q, Brennan, E, Choi, M, Dastani, Z, Drong, A, Eriksson, P, Franco-Cereceda, A, Gadin, J, Gharavi, A, Goddard, M, Handsaker, R, Huang, J, Karpe, F, Kathiresan, S, Keildson, S, Kiryluk, K, Kubo, M, Lee, J, Liang, L, Lifton, R, Ma, B, Mccarroll, S, Mcknight, A, Min, J, Moffatt, M, Montgomery, G, Murabito, J, Nicholson, G, Nyholt, D, Okada, Y, Perry, J, Dorajoo, R, Reinmaa, E, Salem, R, Sandholm, N, Scott, R, Stolk, L, Takahashi, A, Van't Hooft, F, Vinkhuyzen, A, Westra, H, Zheng, W, Zondervan, K, Heath, A, Arveiler, D, Bakker, S, Beilby, J, Bergman, R, Blangero, J, Bovet, P, Campbell, H, Caulfield, M, Cesana, G, Chakravarti, A, Chasman, D, Chines, P, Collins, F, Crawford, D, Cupples, L, Cusi, D, Danesh, J, de Faire, U, Den Ruijter, H, Dominiczak, A, Erbel, R, Erdmann, J, Eriksson, J, Farrall, M, Felix, S, Ferrannini, E, Ferrieres, J, Ford, I, Forouhi, N, Forrester, T, Franco, O, Gansevoort, R, Gejman, P, Gieger, C, Gottesman, O, Gudnason, V, Gyllensten, U, Hall, A, Harris, T, Hattersley, A, Hicks, A, Hindorff, L, Hingorani, A, Hofman, A, Homuth, G, Hovingh, G, Humphries, S, Hunt, S, Hypponen, E, Illig, T, Jacobs, K, Jarvelin, M, Jockel, K, Johansen, B, Jousilahti, P, Jukema, J, Jula, A, Kaprio, J, Kastelein, J, Keinanen-Kiukaanniemi, S, Kiemeney, L, Knekt, P, Kooner, J, Kooperberg, C, Kovacs, P, Kraja, A, Kumari, M, Kuusisto, J, Lakka, T, Langenberg, C, Marchand, L, Lehtimaki, T, Lyssenko, V, Mannisto, S, Marette, A, Matise, T, Mckenzie, C, Mcknight, B, Moll, F, Morris, A, Murray, J, Nelis, M, Ohlsson, C, Oldehinkel, A, Ong, K, Madden, P, Pasterkamp, G, Peden, J, Peters, A, Postma, D, Pramstaller, P, Price, J, Qi, L, Raitakari, O, Rankinen, T, Rao, D, Rice, T, Ridker, P, Rioux, J, Ritchie, M, Rudan, I, Salomaa, V, Samani, N, Saramies, J, Sarzynski, M, Schunkert, H, Schwarz, P, Sever, P, Shuldiner, A, Sinisalo, J, Stolk, R, Strauch, K, Tonjes, A, Tregouet, D, Tremblay, A, Tremoli, E, Virtamo, J, Vohl, M, Volker, U, Waeber, G, Willemsen, G, Witteman, J, Zillikens, M, Adair, L, Amouyel, P, Asselbergs, F, Assimes, T, Bochud, M, Boehm, B, Boerwinkle, E, Bornstein, S, Bottinger, E, Bouchard, C, Cauchi, S, Chambers, J, Chanock, S, Cooper, R, de Bakker, P, Dedoussis, G, Ferrucci, L, Franks, P, Froguel, P, Groop, L, Haiman, C, Hamsten, A, Hui, J, Hunter, D, Hveem, K, Kaplan, R, Kivimaki, M, Kuh, D, Laakso, M, Liu, Y, Martin, N, Marz, W, Melbye, M, Metspalu, A, Moebus, S, Munroe, P, Njolstad, I, Oostra, B, Pedersen, N, Perola, M, Perusse, L, Peters, U, Power, C, Quertermous, T, Rauramaa, R, Rivadeneira, F, Saaristo, T, Saleheen, D, Sattar, N, Schadt, E, Schlessinger, D, Slagboom, P, Snieder, H, Spector, T, Thorsteinsdottir, U, Stumvoll, M, Tuomilehto, J, Uitterlinden, A, Uusitupa, M, van der Harst, P, Walker, M, Wallaschofski, H, Wareham, N, Watkins, H, Weir, D, Wichmann, H, Wilson, J, Zanen, P, Borecki, I, Deloukas, P, Fox, C, Heid, I, O'Connell, J, Strachan, D, Stefansson, K, van Duijn, C, Abecasis, G, Franke, L, Frayling, T, Mccarthy, M, Visscher, P, Scherag, A, Willer, C, Boehnke, M, Mohlke, K, Lindgren, C, Beckmann, J, Barroso, I, North, K, Ingelsson, E, Hirschhorn, J, Loos, R, Speliotes, E, Thompson, J, Goldstein, B, Konig, I, Cazier, J, Grundberg, E, Havulinna, A, Ho, W, Hopewell, J, Eriksson, N, Lundmark, P, Lyytikainen, L, Rafelt, S, Tikkanen, E, Van Zuydam, N, Voight, B, Ziegler, A, Altshuler, D, Balmforth, A, Braund, P, Burgdorf, C, Claudi-Boehm, S, Cox, D, Do, R, El Mokhtari, N, Fontanillas, P, Hager, J, Han, B, Kang, H, Kessler, T, Knowles, J, Kolovou, G, Langford, C, Lokki, M, Lundmark, A, Meisinger, C, Melander, O, Maouche, S, Nikus, K, Rasheed, A, Rosinger, S, Rubin, D, Rumpf, M, Schafer, A, Sivananthan, M, Song, C, Stewart, A, Thorgeirsson, G, van der Schoot, C, Wagner, P, Wells, G, Wild, P, Tsun-Po, Y, Basart, H, Brambilla, P, Cambien, F, Cupples, A, Dehghan, A, Diemert, P, Epstein, S, Evans, A, Ferrario, M, Gauguier, D, Hazen, S, Holm, H, Iribarren, C, Jang, Y, Kahonen, M, Kee, F, Kim, H, Klopp, N, Kuulasmaa, K, Laaksonen, R, Ouwehand, W, Parish, S, Park, J, Rader, D, Shah, S, Stark, K, Wallentin, L, Zimmermann, M, Nieminen, M, Sandhu, M, Pastinen, T, Zalloua, P, Siegbahn, A, Schreiber, S, Ripatti, S, Blankenberg, S, O'Donnell, C, Reilly, M, Collins, R, Roberts, R, Pattaro, C, Kottgen, A, Garnaas, M, Boger, C, Fuchsberger, C, Olden, M, Chen, M, Tin, A, Taliun, D, Li, M, Gao, X, Yang, Q, Hundertmark, C, Foster, M, O'Seaghdha, C, Glazer, N, Liu, C, Struchalin, M, Li, G, Johnson, A, Gierman, H, Hwang, S, Atkinson, E, Lohman, K, Cornelis, M, Chouraki, V, Holliday, E, Sorice, R, Deshmukh, H, Ulivi, S, Chu, A, Murgia, F, Imboden, M, Kollerits, B, Pistis, G, Launer, L, Aspelund, T, Eiriksdottir, G, Mitchell, B, Schmidt, H, Cavalieri, M, Rao, M, Hu, F, de Andrade, M, Turner, S, Ding, J, Andrews, J, Freedman, B, Doring, A, Kolcic, I, Zemunik, T, Boban, M, Minelli, C, Wheeler, H, Igl, W, Zaboli, G, Wild, S, Ellinghaus, D, Nothlings, U, Jacobs, G, Biffar, R, Endlich, K, Ernst, F, Kroemer, H, Nauck, M, Stracke, S, Volzke, H, Aulchenko, Y, Polasek, O, Hastie, N, Vitart, V, Helmer, C, Wang, J, Ruggiero, D, Bergmann, S, Viikari, J, Nikopensius, T, Province, M, Ketkar, S, Colhoun, H, Robino, A, Giulianini, F, Kramer, B, Portas, L, Buckley, B, Adam, M, Thun, G, Paulweber, B, Haun, M, Sala, C, Metzger, M, Mitchell, P, Ciullo, M, Kim, S, Vollenweider, P, Gasparini, P, Pirastu, 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A., Freitag D. F., Gurdasani D., Heikkila K., Johnson T., Kaakinen M., Kettunen J., Li X., Montasser M. E., Petersen A. K., Saxena R., Service S. K., Sidore C., Surakka I., Teslovich T. M., Van den Herik E. G., Volcik K. A., Wu Y., Asiki G., Been L. F., Burnett M. S., Elliott P., Eyjolfsson G. I., Goodarzi M. O., Gravito M. L., Hartikainen A. L., Hung Y. J., Jones M. R., Kaleebu P., Khaw K. T., Kim E., Komulainen P., Lin S. Y., Narisu N., Nieminen T. V., Nsubuga R. N., Olafsson I., Palotie A., Papamarkou T., Pomilla C., Pouta A., Ruokonen A., Seeley J., Silander K., Tiret L., van Pelt L., Wainwright N., Wijmenga C., Young E. H., Bennett F., Boomsma D. I., Burnier M., Chen Y. D., Feranil A. B., Freimer N. B., Hsiung C. A., Kesaniemi A., Koudstaal P. J., Krauss R. M., Kyvik K. O., Meneton P., Moilanen L., Sanghera D. K., Sheu W. H., Whitfield J. B., Wolffenbuttel B. H., Ordovas J. M., Rich S. S., Johnson A., Johnson L., Larson M., Levy D., Newton-Cheh C., O'reilly P., Palmas W., Rice K., Smith A., Snider H., Tobin M., Verwoert G., Rice K. M., Verwoert G. C., Pihur V., Heath S., Sober S., Arora P., Zhang F., Lucas G., Milaneschi Y., Parker A. N., Fava C., Fox E. R., Go M. J., Sjogren M., Vinay D., Alexander M., Tabara Y., Shaw-Hawkins S., Whincup P. H., Shi G., Seielstad M., Sim X., Nguyen K. D., Matullo G., Gaunt T. R., Onland-Moret N. C., Cooper M. N., Platou C. G., Org E., Hardy R., Dahgam S., Palmen J., Kuznetsova T., Uiterwaal C. S., Adeyemo A., Ludwig B., Tomaszewski M., Tzoulaki I., Palmer N. D., Chang Y. P., Steinle N. I., Grobbee D. E., Morrison A. C., Najjar S., Hadley D., Brown M. J., Connell J. M., Day I. N., Lawlor D. A., Lawrence R. W., Ongen H., Li Y., Young J. H., Bis J. C., Bolton J. A., Chaturvedi N., Islam M., Jafar T. H., Kulkarni S. R., Howard P., Guarrera S., Ricceri F., Emilsson V., Plump A., Weder A. B., Sun Y. V., Scott L. J., Peltonen L., Vartiainen E., Brand S. M., Staessen J. A., Wang T. J., Burton P. R., Artigas M. S., Dong Y., Wang X., Zhu H., Rudock M. E., Heckbert S. R., Smith N. L., Wiggins K. L., Doumatey A., Shriner D., Veldre G., Viigimaa M., Kinra S., Prabhakaran D., Tripathy V., Langefeld C. D., Rosengren A., Thelle D. S., Corsi A. M., Singleton A., Hilton G., Salako T., Iwai N., Kita Y., Ogihara T., Ohkubo T., Okamura T., Ueshima H., Umemura S., Eyheramendy S., Meitinger T., Cho Y. S., Kim H. L., Scott J., Sehmi J. S., Hedblad B., Nilsson P., Smith G. D., Raffel L. J., Yao J., Schwartz S. M., Ikram M., W L., Mosley T. H., Seshadri S., Shrine N. R., Wain L. V., Zitting P., Cooper J. A., van Gilst W. H., Janipalli C. S., Mani K., Yajnik C. S., Mattace-Raso F. U., Lakatta E. G., Orru M., Scuteri A., Ala-Korpela M., Kangas A. J., Soininen P., Tukiainen T., Wurtz P., Ong R. T., Dorr M., Galan P., Hercberg S., Lathrop M., Zelenika D., Zhai G., Meschia J. 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R., Rathmann W., Maerz W., Watanabe R. M., de Geus E. J., Penninx B. W., Toenjes A., Peyser P. A., Korner A., Dupuis J., Cucca F., Balkau B., Bouatia-Naji N., Purcell S., Musunuru K., Ardissino D., Mannucci P. M., Anand S., Engert J. C., Morgan T., Spertus J. A., Stoll M., Girelli D., McKeown P. P., Patterson C. C., Merlini P. A., Berzuini C., Bernardinelli L., Peyvandi F., Tubaro M., Celli P., Fetiveau R., Marziliano N., Casari G., Galli M., Ribichini F., Rossi M., Bernardi F., Zonzin P., Piazza A., Yee J., Friedlander Y., Marrugat J., Subirana I., Sala J., Ramos R., Williams G., Nathan D. M., Macrae C. A., Berglund G., Asselta R., Duga S., Spreafico M., Daly M. J., Nemesh J., Korn J. M., Surti A., Gianniny L., Parkin M., Burtt N., Gabriel S. B., Wright B. J., Ball S. G., Schunkert I., Linsel-Nitschke P., Lieb W., Fischer M., Grosshennig A., Preuss M., Scholz M., Chen Z., Wilensky R., Matthai W., Qasim A., Hakonarson H. H., Devaney J., Pichard A. D., Kent K. M., Satler L., Lindsay J. 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L., Goodloe R., Wilson S., Boston J., Malinowski J., Restrepo N., Oetjens M., Fowke J., Spencer K., Pendergrass S., Le Marchand L., Park L., Tiirikainen M., Kolonel L., Cheng I., Wang H., Shohet R., Stram D., Henderson B., Monroe K., Anderson G., Carlson C., Prentice R., Lacroix A., Wu C., Carty C., Rosse S., Young A., Kocarnik J., Lin Y., Jackson R., Duggan D., Kuller L., He C., Sulem P., Barbalic M., Broer L., Byrne E. M., Gudbjartsson D. F., McArdle P. F., Porcu E., van Wingerden S. W., Zhuang W. V., Lauc L. B., Broekmans F. J., Burri A., Chen C., Corre T., Coviello A. D., D'adamo P., Davies G., Deary I. J., Ebrahim S., Fauser B. C., Ferreli L., Folsom A. R., Hankinson S. E., Hass M., Janssens A. C., Karasik D., Keyzer J., Kiel D. P., Lahti J., Lai S., Laisk T., Laven J. S., Liu J., Lopez L. M., Louwers Y. V., Marongiu M., Klaric I. M., Masciullo C., Melzer D., Newman A. B., Pare G., Peeters P. H., Pop V. J., Raikkonen K., Salumets A., Stacey S. N., Starr J. M., Stathopoulou M. G., Styrkarsdottir U., Tenesa A., Tryggvadottir L., Tsui K., van Dam R. M., van Gils C. H., van Nierop P., Vink J. M., Voorhuis M., Widen E., Wijnands-Van Gent C. J., Yerges-Armstrong L. M., Zgaga L., Zygmunt M., Buring J. E., Crisponi L., Demerath E. W., Streeten E. A., Murray A., Visser J. A., Lunetta K. L., Elks C. E., Cousminer D. L., Koller D. L., Lin P., Smith E. N., Warrington N. M., Alavere H., Berenson G. S., Blackburn H., Busonero F., Chen W., Couper D., Easton D. F., Eriksson J., Foroud T., Kilpelainen T. O., Li S., Murray S. S., Ness A. R., Northstone K., Peacock M., Pennell C. E., Pharoah P., Rafnar T., Rice J. P., Ring S. M., Schork N. J., Segre A. V., Sovio U., Srinivasan S. R., Tammesoo M. L., van Meurs J. B., Young L., Bierut L. J., and Econs M. J.
- Abstract
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10-8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20 % of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
- Published
- 2015
37. Prolonged estrogen deprivation is associated with increased cardiovascular disease risk among women with primary ovarian insufficiency
- Author
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Christ, J., Gunning, M., Palla, G., Eijkemans, R., Lambalk, Cornelis B., Laven, Joop S., and Fauser, B.
- Published
- 2017
38. Ethics of oocyte banking for third-party assisted reproduction: a systematic review
- Author
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Kool, E M, primary, Bos, A M E, additional, van der Graaf, R, additional, Fauser, B C J M, additional, and Bredenoord, A L, additional
- Published
- 2018
- Full Text
- View/download PDF
39. Cardiovascular RiskprofilE - IMaging and gender-specific disOrders (CREw-IMAGO): rationale and design of a multicenter cohort study
- Author
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Zoet, G.A., Meun, C., Benschop, L., Boersma, E., Budde, R.P., Fauser, B., Groot, C.J. de, Lugt, A. van der, Maas, A.H.E.M., Moons, K.G., Lennep, J.E. Roeters van, Roos-Hesselink, J.W., Steegers, E.A., Rijn, B.B. van, Laven, J.S., Franx, A., Velthuis, B.K., Zoet, G.A., Meun, C., Benschop, L., Boersma, E., Budde, R.P., Fauser, B., Groot, C.J. de, Lugt, A. van der, Maas, A.H.E.M., Moons, K.G., Lennep, J.E. Roeters van, Roos-Hesselink, J.W., Steegers, E.A., Rijn, B.B. van, Laven, J.S., Franx, A., and Velthuis, B.K.
- Abstract
Contains fulltext : 176974.pdf (publisher's version ) (Open Access), BACKGROUND: Reproductive disorders, such as polycystic ovary syndrome (PCOS), primary ovarian insufficiency (POI) and hypertensive pregnancy disorders (HPD) like pre-eclampsia (PE), are associated with an increased risk of cardiovascular disease (CVD). Detection of early signs of cardiovascular disease (CVD), as well as identification of risk factors among women of reproductive age which improve cardiovascular risk prediction, is a challenge and current models might underestimate long-term health risks. The aim of this study is to assess cardiovascular disease in patients with a history of a reproductive disorder by low-dose computed tomography (CT). METHODS: Women of 45 - 55 years, who experienced a reproductive disorder (PCOS, POI, HPD), are invited to participate in this multicenter, prospective, cohort study. Women will be recruited after regular cardiovascular screening, including assessment of classical cardiovascular risk factors. CT of the coronary arteries (both coronary artery calcium scoring (CACS), and contrast-enhanced coronary CT angiography (CCTA)) and carotid siphon calcium scoring (CSC) is planned in 300 women with HPD and 300 women with PCOS or POI. In addition, arterial stiffness (non-invasive pulse wave velocity (PWV)) measurement and cell-based biomarkers (inflammatory circulating cells) will be obtained. DISCUSSION: Initial inclusion is focused on women of 45 - 55 years. However, the age range (40 - 45 years and/or >/= 55 years) and group composition may be adjusted based on the findings of the interim analysis. Participants can potentially benefit from information obtained in this study concerning their current cardiovascular health and expected future risk of cardiovascular events. The results of this study will provide insights in the development of CVD in women with a history of reproductive disorders. Ultimately, this study may lead to improved cardiovascular prediction models and will provide an opportunity for timely adjustment of preven
- Published
- 2017
40. Implications of the 2014 Androgen Excess and Polycystic Ovary Syndrome Society guidelines on polycystic ovarian morphology for polycystic ovary syndrome diagnosis
- Author
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Christ, J. P., Gunning, M. N., Fauser, B. C.J.M., Christ, J. P., Gunning, M. N., and Fauser, B. C.J.M.
- Published
- 2017
41. Are women with polycystic ovary syndrome at increased cardiovascular disease risk later in life?
- Author
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Gunning, M. N., Fauser, B. C.J.M., Gunning, M. N., and Fauser, B. C.J.M.
- Published
- 2017
42. RBM online : challenges ahead in scientific publishing
- Author
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Fauser, B C J M and Fauser, B C J M
- Published
- 2017
43. Endocrine and cardiometabolic cord blood characteristics of offspring born to mothers with and without polycystic ovary syndrome
- Author
-
Daan, Nadine M P, Koster, Maria P H, Steegers-Theunissen, Regine P., Eijkemans, Marinus J C, Fauser, B. C J M, Daan, Nadine M P, Koster, Maria P H, Steegers-Theunissen, Regine P., Eijkemans, Marinus J C, and Fauser, B. C J M
- Published
- 2017
44. Implications of the 2014 Androgen Excess and Polycystic Ovary Syndrome Society guidelines on polycystic ovarian morphology for polycystic ovary syndrome diagnosis
- Author
-
UMC Utrecht, MS VPG/Gynaecologie, Child Health, Brain, Circulatory Health, Christ, J. P., Gunning, M. N., Fauser, B. C.J.M., UMC Utrecht, MS VPG/Gynaecologie, Child Health, Brain, Circulatory Health, Christ, J. P., Gunning, M. N., and Fauser, B. C.J.M.
- Published
- 2017
45. Prolonged estrogen deprivation is associated with increased cardiovascular disease risk among women with primary ovarian insufficiency
- Author
-
MS VPG/Gynaecologie, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Brain, Christ, J., Gunning, M., Palla, G., Eijkemans, R., Lambalk, Cornelis B., Laven, Joop S., Fauser, B., MS VPG/Gynaecologie, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Brain, Christ, J., Gunning, M., Palla, G., Eijkemans, R., Lambalk, Cornelis B., Laven, Joop S., and Fauser, B.
- Published
- 2017
46. Are women with polycystic ovary syndrome at increased cardiovascular disease risk later in life?
- Author
-
UMC Utrecht, MS VPG/Gynaecologie, Child Health, Brain, Circulatory Health, Gunning, M. N., Fauser, B. C.J.M., UMC Utrecht, MS VPG/Gynaecologie, Child Health, Brain, Circulatory Health, Gunning, M. N., and Fauser, B. C.J.M.
- Published
- 2017
47. RBM online: challenges ahead in scientific publishing
- Author
-
MS VPG/Gynaecologie, Brain, Circulatory Health, Child Health, Fauser, B C J M, MS VPG/Gynaecologie, Brain, Circulatory Health, Child Health, and Fauser, B C J M
- Published
- 2017
48. Endocrine and cardiometabolic cord blood characteristics of offspring born to mothers with and without polycystic ovary syndrome
- Author
-
MS VPG/Gynaecologie, Groep Timmers, Biostatistiek Onderzoek, Circulatory Health, Child Health, JC onderzoeksprogramma Methodologie, JC onderzoeksprogramma Infectieziekten, Brain, Infection & Immunity, Daan, Nadine M P, Koster, Maria P H, Steegers-Theunissen, Regine P., Eijkemans, Marinus J C, Fauser, B. C J M, MS VPG/Gynaecologie, Groep Timmers, Biostatistiek Onderzoek, Circulatory Health, Child Health, JC onderzoeksprogramma Methodologie, JC onderzoeksprogramma Infectieziekten, Brain, Infection & Immunity, Daan, Nadine M P, Koster, Maria P H, Steegers-Theunissen, Regine P., Eijkemans, Marinus J C, and Fauser, B. C J M
- Published
- 2017
49. Cardiovascular RiskprofilE - IMaging and gender-specific disOrders (CREw-IMAGO): rationale and design of a multicenter cohort study
- Author
-
Zoet, GA, Meun, Cindy, Benschop, L, Boersma, Eric, Budde, Ricardo, Fauser, B, de Groot, CJM, van der Lugt, Aad, Maas, AIR, Moons, KGM, Roeters van Lennep, Jeanine, Roos - Hesselink, Jolien, Steegers, Eric, Rijn, BB, Laven, Joop, Franx, A (Arie), Velthuis, BK, Zoet, GA, Meun, Cindy, Benschop, L, Boersma, Eric, Budde, Ricardo, Fauser, B, de Groot, CJM, van der Lugt, Aad, Maas, AIR, Moons, KGM, Roeters van Lennep, Jeanine, Roos - Hesselink, Jolien, Steegers, Eric, Rijn, BB, Laven, Joop, Franx, A (Arie), and Velthuis, BK
- Published
- 2017
50. Prolonged estrogen deprivation is associated with increased cardiovascular disease risk among women with primary ovarian insufficiency
- Author
-
Christ, J., primary, Gunning, M., additional, Palla, G., additional, Eijkemans, R., additional, Lambalk, C.B., additional, Laven, J.S., additional, and Fauser, B., additional
- Published
- 2017
- Full Text
- View/download PDF
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