197 results on '"Fantin, Bruno"'
Search Results
2. Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial
- Author
-
Valiente, Adoración, de Cueto, Marina, Rodríguez, Ángel, Molina, José, Fischer, Julia, Paul, Gregor, Gallien, Sébastien, Fihman, Vincent, Lacasse, Marion, Coustillères, Francois, Becker, Christian, Fuchs, André, Morata, Laura, Weis, Sebastian, Ponscarme, Diane, Khatchatourian, Lydie, Rouveix, Elisabeth, Merrien, Dominique, Lecomte, Raphaël, Veenemans, Jacobien, Vilchez, Helem H., Kessel, Johanna, Bonten, Marc J.M., Rupp, Jan, Hocqueloux, Laurent, Lucht, Frederic, Stahl, Jean-Paul, Vlek, Anne, Prinz-Langenohl, Reinhild, Tolsma, Violaine, Kaasch, Achim J, López-Cortés, Luis Eduardo, Rodríguez-Baño, Jesús, Cisneros, José Miguel, Dolores Navarro, M, Fätkenheuer, Gerd, Jung, Norma, Rieg, Siegbert, Lepeule, Raphaël, Coutte, Laetitia, Bernard, Louis, Lemaignen, Adrien, Kösters, Katrin, MacKenzie, Colin R, Soriano, Alex, Hagel, Stefan, Fantin, Bruno, Lafaurie, Matthieu, Talarmin, Jean-Philippe, Dinh, Aurélien, Guimard, Thomas, Boutoille, David, Welte, Tobias, Reuter, Stefan, Kluytmans, Jan, Martin, Maria Luisa, Forestier, Emmanuel, Stocker, Hartmut, Vitrat, Virginie, Tattevin, Pierre, Rommerskirchen, Anna, Noret, Marion, Adams, Anne, Kern, Winfried V, Hellmich, Martin, and Seifert, Harald
- Published
- 2024
- Full Text
- View/download PDF
3. Enterococcal pyogenic liver abscesses: high risk of treatment failure and mortality
- Author
-
Oliosi, Emma, Rossi, Geoffrey, Nguyen, Yann, Honsel, Vasco, Bert, Frédéric, Roux, Olivier, Fantin, Bruno, and Lefort, Agnès
- Published
- 2023
- Full Text
- View/download PDF
4. Large retrospective study analysing predictive factors of primary treatment failure, recurrence and death in pyogenic liver abscesses
- Author
-
Rossi, Geoffrey, Nguyen, Yann, Lafont, Emmanuel, Rossi, Benjamin, Canouï, Etienne, Roux, Olivier, Dokmak, Safi, Bert, Frédéric, Fantin, Bruno, and Lefort, Agnès
- Published
- 2022
- Full Text
- View/download PDF
5. Clinical and microbiological characteristics of reflux cholangitis following bilio-enteric anastomosis
- Author
-
Le Bot, Audrey, Sokal, Aurélien, Choquet, Anaïs, Maire, Frédérique, Fantin, Bruno, Sauvanet, Alain, and de Lastours, Victoire
- Published
- 2022
- Full Text
- View/download PDF
6. Spontaneous and postsurgical/traumatic Klebsiella pneumoniae meningitis: two distinct clinico-microbiological entities
- Author
-
Rollin, Guillaume, Rossi, Benjamin, Brisse, Sylvain, Decré, Dominique, Leflon-Guibout, Véronique, Bert, Frédéric, Hoffmann, Isabelle, Decousser, Jean-Winoc, Fantin, Bruno, and Lefort, Agnès
- Published
- 2022
- Full Text
- View/download PDF
7. Specificities of acute cholangitis in patients with cancer: a retrospective comparative study of 130 episodes
- Author
-
Sokal, Aurélien, Chawki, Sylvain, Nguyen, Yann, Sauvanet, Alain, Ponsot, Philippe, Maire, Frédérique, Fantin, Bruno, and de Lastours, Victoire
- Published
- 2022
- Full Text
- View/download PDF
8. Temocillin as an alternative treatment for acute bacterial cholangitis: a retrospective microbiology susceptibility-based study of 140 episodes
- Author
-
Chawki, Sylvain, Sokal, Aurélien, Duprilot, Marion, Henry, Amandine, Leflon-Guibout, Véronique, Nicolas-Chanoine, Marie-Hélène, Fantin, Bruno, and de Lastours, Victoire
- Published
- 2021
- Full Text
- View/download PDF
9. Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial
- Author
-
Kaasch, Achim J, primary, López-Cortés, Luis Eduardo, additional, Rodríguez-Baño, Jesús, additional, Cisneros, José Miguel, additional, Dolores Navarro, M, additional, Fätkenheuer, Gerd, additional, Jung, Norma, additional, Rieg, Siegbert, additional, Lepeule, Raphaël, additional, Coutte, Laetitia, additional, Bernard, Louis, additional, Lemaignen, Adrien, additional, Kösters, Katrin, additional, MacKenzie, Colin R, additional, Soriano, Alex, additional, Hagel, Stefan, additional, Fantin, Bruno, additional, Lafaurie, Matthieu, additional, Talarmin, Jean-Philippe, additional, Dinh, Aurélien, additional, Guimard, Thomas, additional, Boutoille, David, additional, Welte, Tobias, additional, Reuter, Stefan, additional, Kluytmans, Jan, additional, Martin, Maria Luisa, additional, Forestier, Emmanuel, additional, Stocker, Hartmut, additional, Vitrat, Virginie, additional, Tattevin, Pierre, additional, Rommerskirchen, Anna, additional, Noret, Marion, additional, Adams, Anne, additional, Kern, Winfried V, additional, Hellmich, Martin, additional, Seifert, Harald, additional, Valiente, Adoración, additional, de Cueto, Marina, additional, Rodríguez, Ángel, additional, Molina, José, additional, Fischer, Julia, additional, Paul, Gregor, additional, Gallien, Sébastien, additional, Fihman, Vincent, additional, Lacasse, Marion, additional, Coustillères, Francois, additional, Becker, Christian, additional, Fuchs, André, additional, Morata, Laura, additional, Weis, Sebastian, additional, Ponscarme, Diane, additional, Khatchatourian, Lydie, additional, Rouveix, Elisabeth, additional, Merrien, Dominique, additional, Lecomte, Raphaël, additional, Veenemans, Jacobien, additional, Vilchez, Helem H., additional, Kessel, Johanna, additional, Bonten, Marc J.M., additional, Rupp, Jan, additional, Hocqueloux, Laurent, additional, Lucht, Frederic, additional, Stahl, Jean-Paul, additional, Vlek, Anne, additional, Prinz-Langenohl, Reinhild, additional, and Tolsma, Violaine, additional
- Published
- 2024
- Full Text
- View/download PDF
10. Impact of the phenotypic expression of temocillin resistance in Escherichia coli on temocillin efficacy in a murine peritonitis model.
- Author
-
Mallart, Elise, Guerin, François, Amoura, Ariane, Scouarnec, Matthieu Le, Hamon, Antoine, Meouche, Imane El, Chau, Françoise, Lefort, Agnès, Fantin, Bruno, Cattoir, Vincent, and Lastours, Victoire de
- Subjects
ESCHERICHIA coli ,PERITONITIS ,PHENOTYPES ,CEFOTAXIME ,PHARMACOKINETICS - Abstract
Background Temocillin is a narrow spectrum β-lactam active against MDR Enterobacterales. Mechanisms of acquired resistance to temocillin are poorly understood. We analysed resistance mechanisms in clinical isolates of Escherichia coli and evaluated their impact on temocillin efficacy in vitro and in a murine peritonitis model. Methods Two sets of isogenic clinical E. coli strains were studied: a susceptible isolate (MLTEM16S) and its resistant derivative, MLTEM16R (mutation in nmpC porin gene); and temocillin-resistant derivatives of E. coli CFT073: CFT-ΔnmpC (nmpC deletion), CFTbaeS-TP and CFTbaeS-AP (two different mutations in the baeS efflux-pump gene). Fitness cost, time–kill curves and phenotypic expression of resistance were determined. Temocillin efficacy was assessed in a murine peritonitis model. Results MICs of temocillin were 16 and 64 mg/L for MLTEM16S and MLTEM16R, respectively, and 8, 128, 256 and 256 mg/L for E. coli -CFT073, CFT-ΔnmpC, CFTbaeS-TP and CFTbaeS-AP, respectively. No fitness cost of resistance was evidenced. All resistant strains showed heteroresistant profiles, except for CFTbaeS-AP, which displayed a homogeneous pattern. In vitro , temocillin was bactericidal against MLTEM16R, CFT-ΔnmpC, CFTbaeS-TP and CFTbaeS-AP at 128, 256, 512 and 512 mg/L, respectively. In vivo , temocillin was as effective as cefotaxime against MLTEM16R, CFT-ΔnmpC and CFTbaeS-TP, but inefficient against CFTbaeS-AP (100% mortality). Conclusions Heteroresistant NmpC porin alteration and active efflux modification do not influence temocillin efficacy despite high MIC values, unfavourable pharmacokinetic/pharmacodynamic conditions and the absence of fitness cost, whereas homogeneously expressed BaeS efflux pump alteration yielding similar MICs leads to temocillin inefficacy. MIC as sole predictor of temocillin efficacy should be used with caution. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
11. Prediction of the intestinal resistome by a three-dimensional structure-based method
- Author
-
Ruppé, Etienne, Ghozlane, Amine, Tap, Julien, Pons, Nicolas, Alvarez, Anne-Sophie, Maziers, Nicolas, Cuesta, Trinidad, Hernando-Amado, Sara, Clares, Irene, Martínez, Jose Luís, Coque, Teresa M., Baquero, Fernando, Lanza, Val F., Máiz, Luis, Goulenok, Tiphaine, de Lastours, Victoire, Amor, Nawal, Fantin, Bruno, Wieder, Ingrid, Andremont, Antoine, van Schaik, Willem, Rogers, Malbert, Zhang, Xinglin, Willems, Rob J. L., de Brevern, Alexandre G., Batto, Jean-Michel, Blottière, Hervé M., Léonard, Pierre, Léjard, Véronique, Letur, Aline, Levenez, Florence, Weiszer, Kevin, Haimet, Florence, Doré, Joël, Kennedy, Sean P., and Ehrlich, S. Dusko
- Published
- 2019
- Full Text
- View/download PDF
12. Analysis of 15 cases from a monocentric cohort of 307 liver abscesses
- Author
-
Canouï, Etienne, primary, Rossi, Geoffrey, additional, Nguyen, Yann, additional, Lafont, Emmanuel, additional, Rossi, Benjamin, additional, Roux, Olivier, additional, Dokmak, Safi, additional, Bert, Frédéric, additional, Leflon‐Guibout, Véronique, additional, Fantin, Bruno, additional, and Lefort, Agnès, additional
- Published
- 2023
- Full Text
- View/download PDF
13. Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study
- Author
-
Hausfater, Pierre, Pourriat, Jean-Louis, Casalino, Enrique, Riou, Bruno, Pateron, Dominique, Yéni, Patrick, Bricaire, François, Ville, Yves, Azria, Elie, Dommergues, Marc, Bergmann, Jean-François, Wolff, Michel, Mira, Jean-Paul, Guillevin, Loïc, Zuber, Mathieu, Abasse, Soumeth, Aberrane, Saïd, Abgueguen, Pierre, Abokasem, Ayman, Abraham, Bruno, Ache-Papillon, Chantal, Adam, Pascal, Adam, Marie-Noëlle, Adhoute, Xavier, Adoue, Daniel, Afi, Moncef, Afroukh, Nawel, Agha-Mir, Ilhem, Aissa, Nejla, Aissaoui, Liamine, Akerman, Grégory, Akkari, Ali, Al Chaar, Majed, Al Freijat, Faraj, Al-Jalaby, Bachar, Albert, Didier, Albertini, Marie-Thérèse, Albinet, Hélène, Alfonsi, Gwenaël, Ali, Youssef, Chaouche, Zahr-Eddine Ali, Allart, Anne, Alric, Laurent, Améri, Alain, Amoura, Zahir, Ampère, Alexandre, Amroun, Hakim, Ananivi, Amévi, Ancelin, Pascal, André, Thierry, Andremont, Antoine, Andreotti, Dominique, Andriamaneo, Hélinoro, Andriau, Clara, Anglaret, Hélène, Anguel, Nadia, Annaix, Véronique, Anteur, Wassila, Anuset, Delphine, Aoudia, Ourida, Arabi, Miloud, Archambaud, Muriel, Archambaud, Maryse, Ardiet, Emmanuel, Argaud, Laurent, Arista, Sophie, Arlet, Guillaume, Armengaud, Jean, Arnal, Jean-Michel, Arnault, Isabelle, Arsène, Olivier, Assaf, Ziad, Assi, Assi, Assouline, David, Astruc, Dominique, Aubard, Yves, Aubert, Claude, Aubry, Jean-Paul, Auburtin, Marc, Aucher, Philippe, Audeguy, Philippe, Audié, Jean-Pierre, Aumaitre, Hugues, Aumersier, Michel, Auroux, Jean, Autret, Fanny, Auvray, Etienne, Ayach, Badih, Aye, Paul, Ayouz, Khélifa, Bachelier, Marie-Nadège, Badia, Thomas Bachelot Philippe, Badila, Patrice, Bador, Julien, Badurescu, Viorica, Baldesi, Olivier, Bandaly, Françoise, Bandin, Olivia, Bani-Sadr, Firouzé, Bannier, Stéphanie, Baranger, Thierry, Barazer, Isabelle, Barbier, Marie-Christine, Barbier, François, Barbier, Carole, Barbieux, Marianne, Marie, Barboteau, Annick, Barbut, Patricia, Baret, Mylène, Barière, François, Baril, Jean-Yves, Barillot, Isabelle, Barjon, Geneviève, Barnaud, Guilène, Barraduc, Régine, Barraud, Francis, Barraud, Olivier, Barre, Eric, Barrelet, Audrey, Barrier, Jocelyn, Bart, Fréderic, Barthélémy, Gérard, Baty, Gaëlle, Baud, Olivier, Baudel, Jean-Luc, Bay, Jacques-Olivier, Bay, Jérôme, Bazin, Claude, Beague, Sébastien, Beal Ardisson, Dominique, Beaune, Bertrand, Beauplet-Lepage, Anne, Bébéar, Cécile, Bechade, Dominique, Becherrawy, Céline, Becker-Schneider, Michelle, Bednarek, Nathalie, Bedock, Bernard, Begon, Edouard, Bekguesmia, Zaineb, Belaisch-Amart, Joëlle, Belhadj, Karim, Belle, Evelyne, Belmonte, Olivier, Belot, Jean-Pierre, Bemrah, Abdelkader, Ben Soltana, Mouna, Benbara, Amélie, Benddif-Fin, Faiza, Bénézit, François, Benifla, Jean-Louis, Benjelloul, Amine, Benkaci, Yacine, Benkhelil, Abdelaziz, Benoit-Cattin, Thierry, Benoit-Coustou, Sophie, Bensadoun, René-Jean, Bensaid, Thierry, Jacques Bensaude, Raoul, Bérard, Henri, Bercot, Béatrice, Berdin, Bruno, Berger, Marc, Berger, Pierre, Bergheul, Smail, Bergues, Benoît, Berland, Yvon, Bernard, Claude, Bernard, Louis, Bernardaud, Bérangère, Bernardi, Franck, Bernardin, Gilles, Bernasconi, François, Bert-Marcaz, Patrick, Berteaux, Béatrice, Berth-Farges, Anne, Berthelot, Gilles, Berthet, Jean, Bertrand, Kevin, Bertrou, Anne, Besnard, Marianne, Bessede, Emilie, Bethery, Philippe, Beuscart, Claude, Beyne-Rauzy, Odile, Beytout, Jean, Bezian, Marie-Christine, Bicais, Brigitte, Bidart, Sabine, Bidault, Christian, Biessy, Hélène, Bigot, Pierre, Bildea, Adrianna, Bille, Emmanuelle, Billy, Christophe, Biron, Nathalie, Bizet, Jérôme, Blaise, Didier, Blaise, Agathe, Blaison, Gilles, Blaka, Mariam, Blanc, Pierre, Blanc, Stéphane, Blanc-Amrane, Véronique, Blanchard, Pierre, Blanchard-Marche, Geneviève, Blancs, Michèle, Blazejewski, Caroline, Bléher, Yves, Blewoussi, Koffi, Blondet, Romain, Blot, François, Blum, Georges-Fabrice, Bodson, Lucien, Boidin, Emilie, Boileau, Julien, Boileau, Pascal, Boin-Gay, Véronique, Boisseau, Martial, Boisselier, Christine, Bollaert, Pierre-Edouard, Bolot, Pascal, Bonacorsi, Stéphane, Bonfils, Marie, Bonitchi, Pascal, Bonnan, Mickael, Bonnefoy, Philippe, Bonnet, Delphine, Bonnet, Richard, Bonnin, Emmanuelle, Bor, Jacques, Borie, Marie-Françoise, Borstein, Bernard, Bossi, Philippe, Botreau, Yves, Bottero, Julie, Bouasria, Abderrezak, Bouaziz, Radia, Bouchaud, Olivier, Bouche, Flore, Bouchet, Gérard, Bouden, Vincent, Boudhane, Amar, Boudy, Carole-Anne, Boue, François, Bouet, Cédric, Claude Boufetteau, Jean, Bouffandeau, Bernard, Bouhour, Damien, Bouiller, Marc, Bouillet, Laurence, Bouissou, Antoine, Boulain, Luc, Bourgeois, Stéphane, Bourgerette, Evelyne, Bourlet, Anne, Bourlière, Marc, Bourrée, Thomas, Bourrouillou, Aude, Boussekey, Nicolas, Boussier, Remi, Boutoille, David, Bouyer, Jean-Luc, Bouyssou-Destriau, Denise, Bouziges, Nicole, Boyer, Michelle, Braem, Louis, Branger, Bernard, Branger, Catherine, Brasme, Lucien, Bray, Philippe, Brazille, Patricia, Bresson, Violaine, Bret, Laurent, Breton, Anne-Laure, Breuil, Jacques, Brevet, Françoise, Briaud, Michel, Bridoux, Delphine, Briend, Delphine, Briere, Anne-Isabelle, de la Hosseraye, Claire Briere, Brieu, Nathalie, Brieux, Jean-Philippe, Brihier, Hélène, Brisou, Patrick, Brival, Marie-Laure, Broche, David, Brochen, Joëlle, Bron, Camille, Bronet, Nathalie, Bronner, Jacques, Bronowicki, Jean-Pierre, Brosset, François, Brottier-Mancini, Elisabeth, Brovedani, Sophie, Bruley des Varannes, Stanislas, Brunel, Pascale, Brunet, Patrick, Brunet, Xavier, Brunet, Stéphanie, Brung-Lefebvre, Maud, Brunot, Vincent, Brusset, Alain, Burc-Struxiano, Laurence, Burdin, Michèle, Bureau, Thierry, Buron, Fanny, Burucoa, Christophe, Cabalion, Jean, Cabasson, Severine, Cabié, André, Cacheux, Victoria, Cadiergue, Vincent, Cadiot, Guillaume, Caille, Vincent, Cailleaux Pierre-Etienne Cailleux, Vincent, Caillon, Jocelyne, Caillot, Denis, Camara, Mohamed, Cambau, Emmanuelle, Cambonie, Gilles, Camiade, Sabine, Canis, Frederique, Canitrot, Meriem, Canu, Nathalie, Capellier, Gilles, Carbillon, Lionel, Carbonelle, Bernard, Carbonelle, Etienne, Carboni, Marion, Carbonne, Bruno, Carcenac, Francis, Cardot, Florence, Carette, Sylvie, Cariou, Sylvie, Carli, Pierre, Carmagnol, Françoise, Caroli-Bosc, François-Xavier, Caron, François, Cartron, Guillaume, Casali, Patrick, Casanovas, Olivier, Cassignard, Dominique, Castaing, Denis, Castel, Brisse, Castelin, Sandrine, Castelnau, Pierre, Cathebras, Pascal, Catineau, Jean, Catteu, Sylviane, Cattier, Blandine, Cattoen, Christian, Cattoir, Vincent, Caumes, Eric, Caussin, Jean, Cavalié, François, Ceppa, Franck, Cerf, Charles, Ceriez, Anne, Cervantes, Nathalie, Chabanon-Pouget, Bruno, Chabrol, Amélie, Chachaty, Elisabeth, Chahtour, Hanen, Chaix, Fabrice, Challier, Marion, Chalvon-Demersay, Arnaud, Chambreuil, Guy, Chaminade, Bruno, Chamouine, Abdourahim, Chandesris Joséphine Chapalain-Cagnon, Christine, Chapelle, Alain, Chaplain, Chantal, Chapuzet, Claire, Charachon, Sylvie, Charasse, Christophe, Charbonnier, Thierry, Charlier, Franck, Chassin, Olivier, Chassy, Véronique, Chatellier, Delphine, Chatron, Marlène, Chaussade, Hélène, Chavanet, Pascal, Chavel, Pascale, Chekroun, Ali, Chelle, Wladimir, Chelly, Jonathan, Cherlet, Christel, Chevailler, Alain, Chevalet, Pascal, Chevalier, Yannick, Chidiac, Christian, Chimot, Loïc, Chiouk, Nabil, Chiron, Philippe, Chirouze, Catherine, Chopin, Marie-Charlotte, Choukroun, Gabriel, Chouraqui, Martine, Chraibi, Kamilla, Chudersky, Dominique, Chuzeville, Michel, Cingotti, Michel, Cinquetti, Gael, Ciocan, Dragos, Citony, Isabelle, Claise, Catherine, Clarissou-Philippe, Juliette, Claude, Benoît, Clave, Danielle, Clément, Christophe, Climas, Marie-Thérèse, Coetmeur, Daniel, Cognet, Stéphanie, Cohen, Daniel, Coignard, Sophie, Coindre, Jean-Philippe, Coint, Raphaël, Colamarino, Renato, Colingorski, Anne-Marie, Collard, Olivier, Collet, Michel, Collignon, Anne, Collus, Marie-José, Colombani, Jean-Claude, Colombat, Philippe, Combe, Christian, Condominas, Philippe, Conroy, Marie-Chrsitine, Constans, Thierry, Constantin, Nicole, Contamin, Claudine, Corberand, Damien, Cordier, Anne-Marie, Cordonnier, Charlotte, Corneloup, Hélène, Costa, Yannick, Costa, Frédérique, Coste, Mathieu, Costes, Corinne, Cotes, Françoise, Cotteret, Rabea, Couderc, Louis-Jean, Cougoul, Pierre, Coulaud, Jean-Michel, Coulhon, Marie-Pierre, Coulon, Patrice, Courcol, René, Courillon, Florence, Courjon, Johan, Courouble, Jérémie, Courouge-Dorcier, Dominique, Courtade, Henri, Courtois, Stéphanie, Couturier, Pascal, Créange, Alain, Cremet, Lise, Cremniter, Julie, Croize, Jacques, Crombe, Valérie, Croquet, Ingrid, Cua, Eric, Cufi, Marie-Noelle, Cuvillier, Patrice, Dabysing, Marie-Françoise, Dadoun, Karim, Dagada, Corinne, Dahan, Sonia, Dahoumane, Redouane, Daleas, Jacques, Dallay, Dominique, Dalle, Benoît, Damage, Alexandre, Damaj, Lena, Damaj Gandhi, Laurent, Danalaché, Ana, Danin, Pierre-Eric, Danjean, Marie-Pierre, Danquechin Dorval, Etienne, Dao, Anne, Daoud, Patrick, Darchen, Olivier, Dargère, Sylvie, Darre, Bincy, Dassant, Damien, Dassieu, Gilles, Dattin-Dorrière, Valérie, Daupin, Cedric, Daurel, Claire, Dausset, Jean-Claude, Daval Cote, Mélanie, David, Gary, Davido, Benjamin, De Barbeyrac, Bertille, De Biasi, Michel, De Boysson, Hubert, De Clareuil, Edith, De Kermadec, Jean-Michel, De Martino, Sylvie, De Tayrac, Renaud, De Varax, Roland, De Witte, Sten, Debernardi, Anne, Deboutin, Jean-Luc, Debouverie, Marc, Decoene, Christophe, Decoster, Anne, Decousser, Jean-Winoc, Decré, Dominique, Defebvre, Renaud, Degand, Nicolas, Degreff, Jean-Marc, Deiber, Michel, Delaby, Hélène, Delacour, Thierry, Delahaye, Arnaud, Delarbre, Jean-Marie, Delasalle, Chantal, Delbrouck, Claire, Delecalle, Jean-Gilles, Delesalle, Sophie, Delesalle, Chantal, Delhoustal, Laurence, Deligne, Delphine, Delisle Mizon, Françoise, Delobel, Pierre, Delour, Pierre, Delpeuch, Bruno, Demachy, Marie-Claude, Demarchi, Martin, Demarcq, Marie-Joelle, Demontclos, Henri, Dengo, Jean-Christophe, Deprecq, Sophie, Dequin, Pierre-François, Dereeper, Olivier, Deroux, Alban, Derragui, Aicha, Desblache, Julien, Desbois-Nogard, Nicole, Descamps, Dominique, Descamps, Jean-Michel, Deschamps, Christophe, Deschamps, Jacques, Desemerie, Franck, Desfrere, Luc, Desliers, Joelle, Desnoulez, Laurence, Desplaces, Nicole, Després, Nicolas, Dessin, Jean-François, Destors, Marie, Detante, Olivier, Detave, Mathieu, Detourmignies, Laurence, Devaud, Edouard, Devaux, Yves, Devaux, Bruno, Devianne, François, Devidas, Alain, Devos, Philippe, Dewitte, Camille, Dewulf, Gisèle, Dhennain, Chantal, Di Meglio, Chloé, Diallo, Habiboulaye, Diamantis, Sylvain, Dib, Baihas, Didier, Jean-Marc, Dillies, Anne-Françoise, Dingremont, Claire, Djafari, Noureddine, Djeffal, Abdelmajid, Djerad, Hama, Dollon, Christophe, Doloy, Alexandra, Domart, Yves, Donay, Jean-Luc, Dopeux, Loïc, Dorr, Gaelle, Doucet Populaire, Florence, Dournon, Nathalie, Dreyfus, Michel, Dreyfuss, Didier, Du Cheyron, Damien, Dubois, Elodie, Dubois, Nicolas, Dubosc-Marchenay, Nadine, Dubourdieu, Béatrice, Dubroca, Nadine, Dubus, Jean-Christophe, Duche, Catherine, Duchene, Francis, Dudeffant, Patrick, Duez, Jean-Marie, Duhaut, Pierre, Duluc, Françoise, Dumouchel, Hélène, Dumoulard, Bruno, Dupin, Clarisse, Dupon, Michel, Dupont, Mathieu, Dupont, Damien, Dupont, Patrick, Dupre-Narlet, Emmanuelle, Dupretz, Peggy, Dupuy, Claire-Antoinette, Durand, Michel, Durand, Annie, Durliat-Ellie, Solène, Durox, Hélène, Dussopt, Christine, Dutasta, Fabien, Duval, Véronique, Dzeing, Ella, Eboue, Florence, Ede, Cyrille, Eid, Hanna, El Yamani, Abderrazak, Elbez, Annie, Eldeghedy, Mohamed, Elena-Daumas, Martine, Elhadad, Simon, Elharie-Heraux, Zoubida, Eloy, Clarence, Emeriau, Marie-Etiennette, Emond, Jean-Philippe, Equy, Véronique, Erena-Penet, Anne-Sophie, Esnault, Cecilia, Esposito, Laure, Essouri, Sandrine, Estépa, Laurence, Estève, Vincent, Etchemendy, Sabine, Ettahar, Nicolas, Eustache, Marie-Line, Evillard, Mathieu, Evreux, Françoise, Eychene, Jean-Marc, Eyer, Didier, Eymerit, Philippe, Fabre, Jean-Luc, Fabre, Claire, Faibis, Frédéric, Falchero, Lionel, Falguières, Odile, Fallouh, Hassan, Fanjaud, Nicolas, Fantin, Bruno, Farah, Ibrahim, Farto-Bensasson, Fernanda, Fauchais, Anne-Laure, Fauchart, Jean-Pierre, Faucher, Anna, Faucheux, Jean-Marc, Faudon-Gibelin, Anne, Faurie, Pierre, Fèbre, Claudine, Feddal, Toufik, Ferhat Carre, Assia, Ferreira-Maident, Nicole, Ferreyra, Milagros, Ferroni, Agnès, Ferry, Tristan, Feugier, Pierre, Feugier, Jean-Claude, Fezoui, Hacene, Fiette, Hélène, Fille, Alexandra, Filloux, Jean-Michel, Fily, Fabien, Fines, Marguerite, Fissore Magdelein, Cristel, Flahault, Mathilde, Floriot, Christian, Foguem, Clovis, Fonsale, Nathalie, Fontenel, Benoît, Forest, Anne-Marie, Forest, Anne, Forestier, Emmanuel, Fortin, Louise, Fortineau, Nicolas, Fos, Marie-Pierre, Foucart, Saskia, Fouilhoux, Alain-Charles, Fournel, Pierre, Fournier, Damien, Fourrier, François, Fraisse, Thibaut, Fredenucci, Isabelle, Fremin-Batteux, Odile, Frey, Janine, Frimat, Luc, Froidure, Marie, Fruchart, Christophe, Fruleux, Nathalie, Fuhrmann, Christine, Fuillet, Michel, Funakoshi, Nathalie, Fur, Alain, Gabez-Therou, Patricia, Gaborieau, Valerie, Gabriel-Soléan, Sylvie, Gachassin, Laurence, Gaide, Jean-François, Gaillard, Julia, Gaillard, Jean-Louis, Gaillart, Tiphaine, Gaizi, Sad, Gallo, Nicolas, Gameiro, Manuel-Luis, Garandeau, Caroline, Garbi, Aurelie, Garcera, Yves, Gardes, Ghislaine, Garesslin, Olivier, Garnier, Fabien, Garofano, Marie, Garosi, Olivier, Garre, Michel, Garrec, Hélène, Garrigues, Bernard, Gaschet, Anne, Gascon, Alexandre, Gascou, Emmanuel, Gasnault, Jacques, Gatfosse, Marc, Gattault, Jean-François, Gatti, Hélène, Gauche, Bernard, Gaudard, Philippe, Gaudelus, Joel, Gaudry, Stéphane, Gauduchon, Valérie, Gaulthier, Jean-Baptiste, Gauthier, Yvan, Gebeile, Rémi, Geffray, Loïc, Geffroy, Françoise, Geissler, Alain, Gelez, Maud, Gendrin, Vincent, Gengembre, Guy, Gentilhomme, Hervé, Gérart Pons, Sandrine, Germain, Marie-Claude, Gesquière, Julien, Ghedira, Adel, Ghevaert, Christine, Gillot, Jean-Michel, Girard, Edouard, Girard, Serge, Girard, Pierre-Marie, Girard-Buttaz, Isabelle, Giraud, Martine, Glorieux, Isabelle, Goburdhun, Chandrah, Godin, Michel, Godon, Catherine, Goehringer, François, Goffart, Sylvie, Goidin, Isabelle, Goldgran Toledano, Daniele, Golfier, François, Goll, Armand, Gontieron, Olivier, Goquelin, Anne, Got, Laurence, Goudeau, Alain, Goujard, Cécile, Goupil, François, Gouraud, François, Gourlaouen, Alain, Gournay, Jérôme, Goustille, Julien, Goux, Alain, Grandclerc, Benoît, Grange, Jean-Didier, Granger, Thierry, Granier, Françoise, Granier, Michèle, Grasset, Denis, Gravet, Alain, Grawey, Isabelle, Greder Belan, Alix, Grelaud, Jean-Jacques, Grenet, Karine, Gressier, Bernard, Grignon, Bernadette, Grimprel, Emmanuel, Grise, Geneviève, Grobost, Vincent, Gross Goupil, Marine, Grossi, Olivier, Gruffat, Brigitte, Gruson, Anne, Guénard, Yves, Guérard, Arnaud, Guérin, Bruno, Guérin, Mathilde, Guérin, Claude, Guerquin, Bernard, Guerrot, Dominique, Guéry, Benoît, Gueudet, Philippe, Gueugniaud, Pierre-Yves, Guichard, Isabelle, Guichart, François, Guiden, Ozel, Guider, Bertrand, Guillarmé Grossmann, Pascale, Guillemot, François, Guillet, Pierre, Guillet-Caruba, Christelle, Guillois, Bernard, Guilloy, Olivier, Guimard, Thomas, Guimard, Karine, Guimier, Philippe, Guinard, Jérôme, Guinet, François, Guisset, Olivier, Guitteaud, Karine, Gutmann, Laurent, Guyetand, Severine, Haccourt, Fabian, Hacot, Jean-Pierre, Hadou, Tahar, Haiat, Stéphanie, Haioun, Corinne, Hajjar, Mostapha, Hamitou, Zakaria, Hammami, Sarah, Hamon-Charles, Sophie, Hamou-Plotkine, Laurence, Hanouz, Jean-Luc, Harbi, Samia, Harlé, Jean-Robert, Haro, Sophie, Harou, Christian, Harvey, Thierry, Hatem, Ghada, Hausermann, Marie-Hélène, Hauss, Pierre-Alexandre, Hayoun, Fabrice, Hecham, Moussa, Heches, Xavier, Hedjem, Nourredine, Heidt, Anne, Heisel, Nicolas, Heluwaert, Fréderic, Helvadjian, Thierry, Henni, Tawfiq, Henry-Andrieu, Yanne, Hequet, Delphine, Herbecq, Patrick, Herbrecht, Raoul, Hernu, Romain, Herry, Catherine, Herry, Jean-Paul, Herson, Serge, Heurtaux, Marie-Noelle, Heusse, Emmanuelle, Heyraud-Blanchet, Catherine, Hichri, Yoar, Hilbert, Gilles, Hili, Marie-Thérèse, Hiret, Sandrine, Hittinger, Gilles, Hochart, Anne-Cécile, Hodee, Nathalie, Holstein, Anne, Hombrouk-Alet, Cécile, Hominal, Stéphane, Honderlick, Patrick, Honoré Bouakline, Stéphanie, Hory, Bernard, Hourdebaigt-Larrusse, Pierre, Houssaye, Serge, Houssiaux-Maisonneuve, Nathalie, Hrichi, Abdelkader, Hubert, Didier, Huc, Benoît, Humbert, Karine, Hurel, Dominique, Husson-Wetzel, Stéphanie, Hutin, Pascal, Huttin, Bernard, Hyerle, Laura, Iacobelli, Silvia, Ilunga, Serge, Imbert, Guenièvre, Jabre-Sikias, Elias, Jacob, Jean-Louis, Jacobs, Romain, Jacomy, Dominique, Jacquier, Pascal, Jacquier, Hervé, Jaffarbandjee, Marie-Christine, Jamet, Angéline, Jan, Didier, Jang, Guyro, Jaouen, Anne-Christine, Jardel, Henry, Jarlier, Vincent, Jarrige, Luc, Jarrousse, Bernard, Jauhlac, Benoît, Jault, Véronique, Jault, Thierry, Jaunait, Eric, Javouhey, Etienne, Jean, Rodolphe, Jean, Julie, Jean-Pierre, Hélène, Jeanmaire, Eliette, Jeannot, Katy, Jeddi, Hassen, Jego, Mickael, Jennane, Selim, Join-Lambert, Olivier, Joly, Pascal, Jonquet, Olivier, Josien, Eric, Jouatte, Fabienne, Jouffret, Agnès, Jourde-Chiche, Noémie, Jourdes, Emilie, Jouvencel, Philippe, Jouzel, Charlotte, Julienne, Geneviève, Jullian, Eric, Juven, Agnès, Juvin, Philippe, Kaidomar, Michel, Kaiser, Thomas, Kalfon, Pierre, Kaltenbach, Georges, Kamar, Nassim, Kansau, Imad, Kara, Ali, Karaoui, Leila, Karirisi, Apollinaire, Karkous, Bernard, Kassis, Marie, Kayal, Samer, Keller, Marie, Kemenar, Chrystelle, Kennouche, Samir, Kerchache, Aissa, Kerleau, Jean-Marc, Kervegant, Anne-Gaelle, Khalifa-Thellier, Sandrine, Radhouane-Khanjari, Fethi, Kherouf, Hakim, Khodeir, Nordine, Kibbrecht, Eric, Kim, An, Kisterman, Jean-Paul, Kittschke, Bernard, Klapczynski, Frédéric, Kodzin, Marie-José, Konate, Bano, Kouaho, Sylvain, Koulmann, Laurence, Krechiem, Karim, Kubab, Sarah, Kubiak, Charles, Kurtz, Jean-Emmanuel, Labadie, Philippe, Labarrière, Damien, Labaune-Kiss, Andrea, Labé, Aurélie, Labourdette, Isabelle, Labrousse, Philippe, Labussière, Anne-Sophie, Lachenal, Florence, Lacroix, Jérôme, Lafeuillade, Alain, Lafforgue, Marie-Odile, Lafon, Ingrid, Lagasse, Jean-Pierre, Lagrandeur, Julien, Lalot, Jean-Marc, Lalu, Mélissa, Laluque, Simone, Lamache, Sébastien, Lamarca, Richard, Lamberet, Aurore, Lambert, Thierry, Lambiotte, Fabien, Lamia, Bouchra, Lamoine-Gimet, Ghislaine, Lamour, Armelle, Lamy, Brigitte, Lanba, Patrice, Landgraf, Nathalie, Landraud, Luc, Laporte, Jean-Patrick, Larible, Claire, Larrazet, Fabrice, Larroche, Claire, Lasbasses, Claudine, Lassel, Ludovic, Lassere, Bertrand, Laudat, Patrice, Lauque, Dominique, Laurens, Etienne, Laurent, Frédéric, Lauretta, Raphael, Laurin, Max, Lauzanne, Brigitte, Lavalard, Emmanuelle, Lavenu, Isabelle, Lavigne, Jean-Philippe, Le Baron, François, Le Berre, Rozenn, Le Berruyer, Pierre-Yves, Le Bideau, Marc, Le Boterff, Cécile, Le Chevallier, Sylvain, Le Coustumier, Alain, Le Du, Anne, Le Goff, Valérie, Le Henaff, Catherine, Le Lay, Geneviève, Le Maout, Gilles, Le Pierres, Athéna, Le Pimpec, Patricia, Le Poulain, Marguerite, Le Reste, Anne-Marie, Le Sec, Ludovic, Le Turdu, Françoise, Leautez-Nainville, Sophie, Lebas, Eddy, Leblond, Véronique, Lebreton, Marie-Annick, Lebreton, Didier, Lecaillon-Thibon, Evelyne, Lechat, Sylvie, Lechiche, Catherine, Lecis, Alain, Leclercq, Roland, Lecomte, Claire, Lécuyer, Hervé, Ledru, Sylvie, Leduc, Dominique, Leflon, Véronique, Lefort, Christine, Lefranc, Hélène, Lefrant, Jean-Yves, Legendre, Christophe, Legoff, Isabelle, Legout, Laurence, Legrand, Mathieu, Legras, Annick, Legros, Antoine, Leguen, Virginie, Leibinger, Franck, Lelièvre, Jean-Daniel, Lellouche, Franck, Lemaignen, Adrien, Lemarie, Romain, Lemble, Chantal, Lemenand, Olivier, Lemercier, Fanny, Lemery, Didier, Lemmens, Bruno, Lemyze, Malcolm, Leneveu, Michel, Léonetti, Françoise, Léonnet, Caroline, Léotard, Sophie, Lepeletier, Didier, Lepelletier, Didier, Lepeule, Raphael, Lepiller, Quentin, Lequen, Laurence, Leroux, Lionel, Leroux, Stéphane, Leroy, Hélène, Leroy, Vincent, Leroy, Olivier, Lesage, Fabrice, Lescat, Mathilde, Lesecq, Ludovic, Lessene, Aude, Lessinger, Jean-Marc, Letellier, Claire, Letellier, Nicolas, Letouzey, Vincent, Letranchant, Lorraine, Levast, Marion, Leveneur, Yann, Levent, Thierry, Levy, Marie, Levy, Marc, Leysenne, David, Libeau, Benoît, Likose, Ebutu, Lima, Suzanne, Lina, Gérard, Lioger, Bertrand, Lionnet, Benoît, Lipovac, Anne-Sophie, Loffeier, Vincent, Loison, Françoise, Lorchleac'h, Aurélien, Lorge, Fabienne, Loriferne, Jean-François, Lorléa'ch, Aurélien, Louart, Guillaume, Loury-Lariviere, Isabelle, Loustaud, Véronique, Lozniewski, Alain, Luciani, Roger-Charles, Luminitan Elena Lupean, Luca, Lureau, Pierre, Lutz-Murphy, Marie-France, Mbimba, Luwawu, M'Bey, Damien, Maakaroun, Abdallah, Macci, Valérie, Magdoud, Fatma, Mager, Guy, Magna, Théophile, Magny, Jean-François, Mahaza, Chetaou, Mahé, Isabelle, Maillard, Christine, Maillet, Jean-Jacques, Maillet, François, Maillez, Sébastien, Maillot, François, Maisonneuve, Antoine, Makdessi, Solène, Malbrunot, Claire, Malbruny, Brigitte, Malderet, Caroline, Malfuson, Jean-Valère, Malherbe, Philippe, Malherbe, Patrick, Malhiere, Sophie, Mandelbrot, Laurent, Mandin, Laurent, Mandjee, Aziza, Manéglier, Benjamin, Mansouria, Mohammed, Marcu, Elena, Mariette, Jean-Bernard, Mariette, Sylvie, Markarian, Jacques, Marmouset, Carole, Marpeau, Olivier, Marret, Olivier, Marsepoil, Thierry, Marterl-Lafay, Isabelle, Martha, Benoît, Marthelet, Patrick, Martin, Xavier, Martin, Florence, Martin, Pierre, Martin, Régine, Martin, Christian, Martin Lefèvre, Laurent, Martineau, Olivier, Martinet, Olivier, Martinez, Valérie, Martinot, Martin, Martres, Pascale, Marty, Sophie, Marty-Ane, Charles, Marzouk, Paul, Mascade, Géraldine, Masia, Florent, Masseron, Thierry, Masson, Loïc, Masson, Philippe, Matheron, Isabelle, Matica, Slavius, Matray, Olivier, Mattei, Marie-Françoise, Maubert, Bertrand, Maugein, Jeanne, Maureira, Juan-Pablo, May, Thierry, May, Adrien, Maze, Vincent, Meaudre Desgouttes, Eric, Mebazaa, Alexandre, Mechai, Frédéric, Medeau, Virginie, Megbemado, Richard, Mehri, Mona, Mein-Bottini, Myriam, Melis, Adrien, Mellier, Joelle, Ménager, Philippe, Ménard, Céline, Mendes-Martin, Lucile, Menguy, Anne-Claude, Menouar, Mohamed, Merabet, Taoufik, Mercury, Paul, Meregnani, Corinne, Mérigot, Philippe, Mermont, Sylvain, Merrouche, Yacine, Merville, Pierre-Gilles, Mesnage, Renaud, Mesnard, Louis, Messager, Aurélie, Messiaen, Thierry, Messika, Jonathan, Messner Pellenc, Patrick, Métenier, Hervé, Metton, Pierre, Meyer, Christian, Mialon, Michel, Miatello, Jordi, Michaud-herbst, Alban, Michault, Alain, Micheli, Sophie, Michon, Jocelyn, Baptiste Michot, Jean, Mielczarek, Severine, Mignart, Sophie, Mignaut, Virginie, Migraine Bouvagnet, Audrey, Mihout, Fabrice, Mille, Catherine, Millet, Olivier, Milpied, Noel, Mimoz, Olivier, Minet, Jacques, Minguet, Bertrand, Mohty, Mohamad, Moiton, Marie-Pierre, Monarchi, Richard, Monceau, Yannick, Monchi, Mehran, Monlun, Eric, Monsegu, Jacques, Montagne, Nathalie, Montcriol, Ambroise, Montmasson, Bernard, Mootien, Paramasiven, Moquet, Olivier, Morando, Virginie, Moreau, Anne-Sohie, Morel, Yves, Morelon, Emmanuel, Morin-Fatome, Armelle, Morincomme, Mathieu, Morlat, Philippe, Mosser, Laurent, Motard-Picheloup, Annie, Mottaz, Philippe, Moulinoux, Claire, Mouly, Laurence, Mourad, Georges, Mouries, Jean-Claude, Moussa, Hecham, Moustache, Audrey, Muir, Jean-François, Murbach, Valérie, N'guyen, Yohann, N'guyen, Jean-Claude, N'guyen-Khac, Florence, Nabholtz, Jean-Marc, Naceur, Tarik, Nakhleh, Jean, Nare, Aline, Nassif, Xavier, Nathan-Bonnet, Frédérique, Negrery, Huguette, Negrier, Claude, Neri, Dominique, Nesrine, Hakima, Neuwirth, Catherine, Ngami, Eugène, Carole Ngo Bell, Elisabeth, Nicobaharaye, Dieudonné, Nicolet, Laurent, Nicolet, Laurence, Nicolino, Marc, Niel, Philippe, Nikodijevic, Karine, Nkunzimana, Jean-Marie, Noel, Christian, Noirot, Alain, Noto, Philippe, Noulard, Marie-Noelle, Ntalu Nkato, Christophe, Nyunga, Martine, Obiols, Julien, Ochocki, Patrick, Odent, Sylvie, Olivier, Brigitte, Oliviero, Gérard, Ondze, Basile, Orléva, Oléna, Orode, Paul, Osman, Henri, Oswald, Eric, Otean, Paola, Ouazir, Abderkader, Ozanon, Christophe, Paccalin, Marc, Pages, Marie-Christine, Paindaveine, Bénédicte, Pangon, Béatrice, Pannecouck, Jean-Marie, Paquet, Jean-Christophe, Parent, Sabrina, Parisi-Duchene, Elisabeth, Pasche, Jérôme, Pasdeloup, Thierry, Patin, David, Patrigeon, René-Gilles, Patry, Isabelle, Paul, Jean-Gabriel, Pavel, Simona, Pavic, Michel, Pawlotsky, Jean-Michel, Payan, Christopher, Payen, Christiane, Péan, Yves, Péchinot, Frédérique, Péchinot, André, Pecquet, Matthieu, Pélaquier, Agnès, Peltier, Hervé, Penn, Pascale, Pennaforte, Jean-Loup, Perez, Didier, Périsson, Caroline, Perotin, Dominique, Perouse de Montclos, Michèle, Perreve, Sophie, Perronne, Christian, Perrotin, Dominique, Pesque, Valerie, Pestel-Caron, Martine, Pestre, Vincent, Petassou, Fabrice, Petit, Marie-Cécile, Petit Hoang, Camille, Petitjean, Philippe, Pettinelli, François, Peultier, Anne-Sophie, Piala, Jean-Marie, Pialoux, Gilles, Piau, Caroline, Picard, Aurélia, Picaud, Jean-Charles, Pichard, Eric, Pierre, Martin, Pierre, Fabrice, Pierrot, Paul, Piet, Emilie, Piffaut, Marie-Claude, Pigeon, Bertrand, Pignon, Carole, Pinon, Georges, Piquet, Jacques, Piriou, Vincent, Placidi, Eric, Plainfosse, Gillles, Plane, Christophe, Plantier, Isabelle, Claudiu-Plesa, Nicolai, Plésiat, Patrick, Plessis, Patrick, Plouzeau-Jayle, Chloé, Ploy, Marie-Cécile, Pochmalicki, Gilbert, Pofelski, Joanna, Poinsignon, Yves, Poirier, Anne-Sophie, Poitevin, Françoise, Pommier, Christian, Ponceau, Bénédicte, Poncelet, Christophe, Pop, Daniela, Porcheron, Martine, Pordes, Réginald, Porthault, Eric, Portneuf, Marc, Pottier, Anne, Pouedras, Pascal, Poulain, Jocelyne, Poulain, Gérard, Poupet, Hélène, Pouyanne, Julien, Pouzoullic, Marie, Poyart, Claire, Pozzetto, Bruno, Prazuck, Thierry, Pressac, Dominique, Prévost, Fabrice, Prince, Sylvie, Priollet, Pascal, Proost, Olivier, Protar, Daniel, Pujade Lauraine, Eric, Pujol, Antoine, Puybasset, Louis, Puyhardy, Jean, Quentin, Vincent, Quinsat, Denis, Rabier, Valérie, Radaoui, Fouzia, Radenac, Florian, Radenne, Sylvie, Raffenot, Didier, Raffi, François, Rahmani, Hassène, Ramanantsoa, Céline, Ranchon, Guillaume, Ranta, Dana, Raoult, Didier, Rasigade, Jean-Philippe, Rassiat, Emmanuel, Raulin, Olivia, Ravaud, Alain, Ravet, Nathalie, Razafimahefa, Hasinrina, Razafimahery, Mirana, Re, Daniel, Real, Philippe, Rebattu, Paul, Rebeyrotte, Catherine, Reboul, Pascal, Reboux, Anne-Hélène, Recule, Christine, Redonnet, Jean-Philippe, Redor, Alexis, Regouby, Yves, Rémy, Claude, Renard, Gisèle, Renard, Benoît, Renou, Frédéric, Repellin, Philippe, Reveil, Jean-Claude, Revel, Valérie, Reverseau, Anne, Revest, Mathieu, Rey, Philippe, Rey, Hyacine, Rey Zermati, Jany, Reyes Ortega, Guillermo, Reynaud, Alain, Reynes, Jacques, Rezgui, Nasseur, Riahi, Jacques, Ribes, David, Ribier, Arnaud, Richard, Christian, Richardin, Florence, Riche, Agnès, Richette, Pascal, Ridah, Khalid, Riegel, Philippe, Riehl, Frédéric, Rigaux, Françoise, Rioux, Christophe, Rival, Gilles, Rivière, Brigitte, Robert, Henri, Robert, René, Robillard, Pierre-Yves, Roblin, Mélanie, Roblot, Pascal, Roblot, France, Rogeaux, Olivier, Roger, Pierre-Marie, Rohmer-Heitz, Dominique, Rolland, Christophe, Roncato-Saberane, Mariam, Ronda, Isabelle, Rondepierre, Philippe, Roque-Afonso, Anne-Marie, Rosay, David, Rose, Christian, Roseau, Jean-Baptiste, Rosello, Sophie, Rosselli, Sylvène, Rossignol, Serge, Rostaing, Lionel, Roth, Christian, Rothe, Marie-Rose, Roubert, Xavier, Rouget, Sébastien, Rouidi, Ahmed, Roulier, Philippe, Rouquet, Yannick, Rouquette-Vincent, Isabelle, Roure Sobas, Chantal, Rousseau, Sylvaine, Rousseau, Florence, Roussel, Etienne, Roussel, Jean-Christian, Roussel, Christophe, Roussellier, Patricia, Roy, Christophe, Royer, Daniel, Roze, Jean-Christophe, Rozec, Bertrand, Ruimy, Raymond, Ruppé, Etienne, Ruyer, Olivier, Sabbat, Sébastien, Saghi, Tahar, Saigne, Christophe, Sakek, Necera, Salama, Gilles, Salanoubat, Celia, Salaun-Beretta, Guenaelle, Saliba, Elie, Salles, Gilles, Salmon, Odile, Louis Salomon, Jean, Salord, Jean-Michel, Salvucci, Marina, Samson, Thierry, Sanchez, Richard, Sansot, Dominique, Saplacan, Mihaela, Saroufim, Carlo, Sauder, Philippe, Sautereau, Denis, Savare, Ferdinand, Savatier, Rim, Scemla, Anne, Schendel, Adeline, Schmitt, Anna, Schmitt, François, Schmitt, Alain, Schneerson, Morgane, Schneider, Francis, Schved, Jean-François, Schwebel, Carole, Sebban, Anthony, Secher, Aline, Sédillot, Nicholas, Sedjelmaci, Yacine, Segonds, Christine, Seignovert, Camille, Seknazi, Corinne, Semenescu, Marius, Sément, Arnaud, Semet, Jean-Claude, Semet, Guy, Sennevile, Eric, Serier, Miloud, Serre, Arnaud, Seta, Nathalie, Seyrig, Jacques-Arnaud, Sgro, Eric, Sibony-Prat, Joyce, Sicsic, Jean-Luc, Sifaoui, Farid, Signouret, Thomas, Sigur, Nicolas, Silhadi, Souad, Siméoni, Umberto, Simian, Bernard, Similowski, Thomas, Simon, Georges, Simon, François, Simonin, Catherine, Sirbu, Cristina, Sire, Jean-Marie, Sivadon-Tardy, Valérie, Sivery, Bruno, Slama, Michel, Smati, Salim, Sobesky, Rodolphe, Sokeng-Affoule, Hélène, Sollet, Jean-Pierre, Sommabère, André, Sondag, Daniel, Soraudeau, Florence, Sotto, Albert, Soulie, Bruno, Souply, Laurent, Souquet, Jean-Christophe, Soury, Pierre, Souweine, Bertrand, Stahl, Jean-Paul, Steibach, Marie-Isabelle, Stephan, Robin, Stoclin, Annabelle, Stolidi, Philippe, Strock, Paul, Suatean, Diana, Subra, Jean-François, Sucin, Yves, Suel, Philippe, Sullice, Marc, Szwebel, Tali-Anne, Tacchini, Laurent, Talabani-Boizot, Hana, Talarmin, Jean-Philippe, Taleb, Fethi, Tamalet, Catherine, Tamion, Fabienne, Tandonnet, Olivier, Tankovic, Jacques, Tardy, Véronique, Tassot, Christelle, Taurin, Gregory, Taylor, Sabine, Tchenio, Xavier, Tebib, Jacques, Teillet, Laurent, Teixeira, Antonio, Terki, Mustapha, Tesseydre, Sonia, Texier, Jean-Claude, Texier, Anthony, Thellier, Jean-Paul, Thibaud, Didier, Thibault, Michel, Thibaut, Freddy, Thierry, Jacques, Thoinet, Sylvie, Thomas, Pierre, Thomas, René, Thomas, Yves, Thomas, Caroline, Thore, Jean, Thouret, Jean-Marc, Thouvenin, Maxime, Thuet, Francis, Tigaizin, Ahmed, Tigaud, Sylvestre, Tiry, Catherine, Tissieres, Pierre, Tissot, Alain, Tixier, Anne, Touati, Kamel, Toubia, Marie-Lina, Toullalan, Olivier, Tourani, Jean-Marc, Tourrand, Bernadette, Touze, Yvan, Trabelsi-Jnifen, Asma, Traissac, Laurent, Anh Tran, Tu, Tran, Vanessa, Tricoire, Joelle, Tronchon, Laurent, Trouiller, Sébastien, Trystram, David, Ahmed, Becaid, Tsouria, Tuca, Mirela, Turpin, Mathilde, Vache, Bernard, Vachée, Anne, Vaillant, Christine, Valadier, Patrick, Valayer, Patrick, Valette, Xavier, Vallet, Françis, Van de Velde, Florence, Vanden Einjden, Serge, Vandenesch, François, Vande-perre, Philippe, Varin, Marie-Christine, Vary, Gwenaelle, Vaschalde, Yvan, Vassallo, Matteo, Vasse, Marc, Vasseur, Manica, Vatan, Rémi, Vaucel, Jacques, Vergnaud, Michel, Verhaeghe, Annick, Vermesch-Langlin, Annie, Vernet, Guy, Vernet Garnier, Véronique, Verrier, Virginie, Vessieres, Annie, Vialette, Véronique, Viard, Jean-Paul, Vieillard Baron, Antoine, Vighetto, Alain, Villemain, Marc, Villers, Daniel, Vilque, Jean-Pierre, Vinay, Agnès, Vincent, Didier, Vincent, Pascal, Vincent, Colette, Vincent, Simon, Vinci, Clara, Viole, Didier, Violette, Jérémie, Viquesnel, Gerard, Virlouvet, Anne-Laure, Visentin, Séverine, Vittecoq, Daniel, Vodovar, Dominique, Vrigneaud, Laurence, Vu-Thien, Hoang, Vuotto, Fanny, Wafo, Estelle, Wagner, Michel, Walid, Nicola, Walter, Elisabeth, Watson, Sarah, Weinbreck, Pierre, Weinbronn, Eva, Weiss, Emmanuel, Weitten, Thierry, Welker, Yves, Westeel, Pierre-François, Wink, Olivier, Wintenberger, Claire, Woerther, Paul-Louis, Worcel, Isabelle, Wuillai, Anne, Wurmser, Marc, Xavier, Jacob, Yazdanpanah, Yazdan, Yehia, Aihem, Yvenou, Sterenn, Zagdoun, Elie, Zagozda, Dominique, Zame, Thierry-Pascal, Zamfiri, Oana, Zanaldi, Hélène, Zandecki, Marc, Zaoui, Eric, Zarrouk, Virginie, Zarski, Jean-Pierre, Zavadil, Patrick, Zeller, Valérie, Zerbib, Franck, Zerr, Vincent, Zgarni, Lémia, Zoulim, Fabien, Zoveda, Patrick, Zuber, Pierre, Zumbo, Christian, Charlier, Caroline, Perrodeau, Élodie, Leclercq, Alexandre, Cazenave, Benoît, Pilmis, Benoît, Henry, Benoît, Lopes, Amanda, Maury, Mylène M, Moura, Alexandra, Goffinet, François, Dieye, Hélène Bracq, Thouvenot, Pierre, Ungeheuer, Marie-Noëlle, Tourdjman, Mathieu, Goulet, Véronique, de Valk, Henriette, Lortholary, Olivier, Ravaud, Philippe, and Lecuit, Marc
- Published
- 2017
- Full Text
- View/download PDF
14. Hypervirulent Klebsiella pneumoniae in Cryptogenic Liver Abscesses, Paris, France
- Author
-
Rossi, Benjamin, Gasperini, Maria Ludovica, Leflon-Guibout, Veronique, Gioanni, Alice, de Lastours, Victoire, Rossi, Geoffrey, Dokmak, Safi, Ronot, Maxime, Roux, Olivier, Nicolas-Chanoine, Marie-Helene, Fantin, Bruno, and Lefort, Agnes
- Subjects
Klebsiella -- Research ,Pneumonia -- Research ,Abscess -- Diagnosis -- Risk factors ,Health - Abstract
Pyogenic liver abscesses are common intra-abdominal infections (1-4), associated with a substantial severity (5). Most (30%-70%) pyogenic liver abscesses result from a biliary origin (6), followed by a portal origin [...]
- Published
- 2018
- Full Text
- View/download PDF
15. Ceftriaxone promotes the emergence of AmpC-overproducing Enterobacteriaceae in gut microbiota from hospitalized patients
- Author
-
de Lastours, Victoire, Goulenok, Tiphaine, Guérin, François, Jacquier, Hervé, Eyma, Cindy, Chau, Françoise, Cattoir, Vincent, and Fantin, Bruno
- Published
- 2018
- Full Text
- View/download PDF
16. Pharmacokinetics and Pharmacodynamics of Temocillin
- Author
-
Alexandre, Kevin and Fantin, Bruno
- Published
- 2018
- Full Text
- View/download PDF
17. Comparative dynamics of the emergence of fluoroquinolone resistance in staphylococci from the nasal microbiota of patients treated with fluoroquinolones according to their environment
- Author
-
Munier, Anne-Lise, de Lastours, Victoire, Barbier, François, Chau, Françoise, Fantin, Bruno, and Ruimy, Raymond
- Published
- 2015
- Full Text
- View/download PDF
18. Advances in antibacterial treatment of adults with high-risk febrile neutropenia.
- Author
-
Contejean, Adrien, Maillard, Alexis, Canouï, Etienne, Kernéis, Solen, Fantin, Bruno, Bouscary, Didier, Parize, Perrine, Garcia-Vidal, Carolina, and Charlier, Caroline
- Subjects
FEBRILE neutropenia ,DRUG monitoring ,AMIKACIN ,LITERATURE reviews ,BACTERIAL ecology ,MYCOSES ,BETA lactam antibiotics - Abstract
Background High-risk febrile neutropenia (HR-FN) is a life-threatening complication in patients with haematological malignancies or receiving myelosuppressive chemotherapy. Since the last international guidelines were published over 10 years ago, there have been major advances in the understanding and management of HR-FN, including on antibiotic pharmacokinetics and discontinuation/de-escalation strategies. Objectives Summarizing major advances in the field of antibacterial therapy in patients with HR-FN: empirical therapy, pharmacokinetics of antibiotics and antibiotic stewardship. Sources Narrative review based on literature review from PubMed. We focused on studies published between 2010 and 2023 about the pharmacokinetics of antimicrobials, management of antimicrobial administration, and discontinuation/de-escalation strategies. We did not address antimicrobial prophylaxis, viral or fungal infections. Content Several high-quality publications have highlighted important modifications of antibiotic pharmacokinetics in HR-FN, with standard dosages exposing patients to underdosing. These recent clinical and population pharmacokinetics studies help improve management protocols with optimized initial dosing and infusion rules for β-lactams, vancomycin, daptomycin and amikacin; they highlight the potential benefits of therapeutic drug monitoring. A growing body of evidence also shows that antibiotic discontinuation/de-escalation strategies are beneficial for bacterial ecology and patients' outcome. We further discuss methods and limitations for implementation of such protocols in haematology. Implications We highlight recent information about the management of antibacterial therapy in HR-FN that might be considered in updated guidelines for HR-FN management. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
19. Synergistic Activity of Pep16, a Promising New Antibacterial Pseudopeptide against Multidrug-Resistant Organisms, in Combination with Colistin against Multidrug-Resistant Escherichia coli, In Vitro and in a Murine Peritonitis Model
- Author
-
Chosidow, Samuel, primary, Fantin, Bruno, additional, Nicolas, Irène, additional, Mascary, Jean-Baptiste, additional, Chau, Françoise, additional, Bordeau, Valérie, additional, Verdier, Marie-Clemence, additional, Rocheteau, Pierre, additional, Guérin, Francois, additional, Cattoir, Vincent, additional, and de Lastours, Victoire, additional
- Published
- 2023
- Full Text
- View/download PDF
20. qnrA6 genetic environment and quinolone resistance conferred on Proteus mirabilis
- Author
-
Jayol, Aurélie, Janvier, Frédéric, Guillard, Thomas, Chau, Françoise, Mérens, Audrey, Robert, Jérôme, Fantin, Bruno, Berçot, Béatrice, and Cambau, Emmanuelle
- Published
- 2016
- Full Text
- View/download PDF
21. Activity of the combination of colistin and fosfomycin against NDM-1-producing Escherichia coli with variable levels of susceptibility to colistin and fosfomycin in a murine model of peritonitis
- Author
-
Le Menestrel, Alice, primary, Guerin, François, additional, Chau, Françoise, additional, Massias, Laurent, additional, Benchetrit, Laura, additional, Cattoir, Vincent, additional, Fantin, Bruno, additional, and de Lastours, Victoire, additional
- Published
- 2021
- Full Text
- View/download PDF
22. Emergence of quinolone resistance in the microbiota of hospitalized patients treated or not with a fluoroquinolone
- Author
-
de Lastours, Victoire, Chau, Françoise, Roy, Carine, Larroque, Beatrice, and Fantin, Bruno
- Published
- 2014
- Full Text
- View/download PDF
23. Specificities of acute cholangitis in patients with cancer: a retrospective comparative study of 130 episodes
- Author
-
Sokal, Aurélien, primary, Chawki, Sylvain, additional, Nguyen, Yann, additional, Sauvanet, Alain, additional, Ponsot, Philippe, additional, Maire, Frédérique, additional, Fantin, Bruno, additional, and de Lastours, Victoire, additional
- Published
- 2021
- Full Text
- View/download PDF
24. Early primary toxoplasmosis transmitted by liver graft: A case report
- Author
-
Vanjak, Anthony, primary, Canouï, Etienne, additional, Honsel, Vasco, additional, Argy, Nicolas, additional, Houzé, Sandrine, additional, Roux, Olivier, additional, and Fantin, Bruno, additional
- Published
- 2021
- Full Text
- View/download PDF
25. Metagenomic Characterization of Gut Microbiota of Carriers of Extended-Spectrum Beta-Lactamase or Carbapenemase-Producing Enterobacteriaceae Following Treatment with Oral Antibiotics and Fecal Microbiota Transplantation: Results from a Multicenter Randomized Trial
- Author
-
Epi Infectieziekten, MMB, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Leo, Stefano, Lazarevic, Vladimir, Girard, Myriam, Gaïa, Nadia, Schrenzel, Jacques, de Lastours, Victoire, Fantin, Bruno, Bonten, Marc, Carmeli, Yehuda, Rondinaud, Emilie, Harbarth, Stephan, Huttner, Benedikt D, Epi Infectieziekten, MMB, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Leo, Stefano, Lazarevic, Vladimir, Girard, Myriam, Gaïa, Nadia, Schrenzel, Jacques, de Lastours, Victoire, Fantin, Bruno, Bonten, Marc, Carmeli, Yehuda, Rondinaud, Emilie, Harbarth, Stephan, and Huttner, Benedikt D
- Published
- 2020
26. Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19
- Author
-
Garrigues, Eve, primary, Janvier, Paul, additional, Kherabi, Yousra, additional, Le Bot, Audrey, additional, Hamon, Antoine, additional, Gouze, Hélène, additional, Doucet, Lucile, additional, Berkani, Sabryne, additional, Oliosi, Emma, additional, Mallart, Elise, additional, Corre, Félix, additional, Zarrouk, Virginie, additional, Moyer, Jean-Denis, additional, Galy, Adrien, additional, Honsel, Vasco, additional, Fantin, Bruno, additional, and Nguyen, Yann, additional
- Published
- 2020
- Full Text
- View/download PDF
27. Novel Chromosomal Mutations Responsible for Fosfomycin Resistance in Escherichia coli
- Author
-
Cattoir, Vincent, primary, Pourbaix, Annabelle, additional, Magnan, Mélanie, additional, Chau, Françoise, additional, de Lastours, Victoire, additional, Felden, Brice, additional, Fantin, Bruno, additional, and Guérin, François, additional
- Published
- 2020
- Full Text
- View/download PDF
28. Applicability of the CURB-65 pneumonia severity score for outpatient treatment of COVID-19
- Author
-
Nguyen, Yann, primary, Corre, Félix, additional, Honsel, Vasco, additional, Curac, Sonja, additional, Zarrouk, Virginie, additional, Fantin, Bruno, additional, and Galy, Adrien, additional
- Published
- 2020
- Full Text
- View/download PDF
29. A nomogram to predict the risk of unfavourable outcome in COVID-19: a retrospective cohort of 279 hospitalized patients in Paris area
- Author
-
Nguyen, Yann, primary, Corre, Félix, additional, Honsel, Vasco, additional, Curac, Sonja, additional, Zarrouk, Virginie, additional, Burtz, Catherine Paugam, additional, Weiss, Emmanuel, additional, Moyer, Jean-Denis, additional, Gauss, Tobias, additional, Grégory, Jules, additional, Bert, Frédéric, additional, Trichet, Catherine, additional, Peoc’h, Katell, additional, Vilgrain, Valérie, additional, Rebours, Vinciane, additional, Fantin, Bruno, additional, and Galy, Adrien, additional
- Published
- 2020
- Full Text
- View/download PDF
30. Analysis of Paradoxical Efficacy of Carbapenems against Carbapenemase-Producing Escherichia coli in a Murine Model of Lethal Peritonitis
- Author
-
Roujansky, Ariane, primary, de Lastours, Victoire, additional, Guérin, François, additional, Chau, Françoise, additional, Cheminet, Geoffrey, additional, Massias, Laurent, additional, Cattoir, Vincent, additional, and Fantin, Bruno, additional
- Published
- 2020
- Full Text
- View/download PDF
31. Pyogenic liver abscess in liver transplant recipient: A warning signal for the risk of recurrence and retransplantation
- Author
-
Lafont, Emmanuel, primary, Roux, Olivier, additional, Lastours, Victoire, additional, Dokmak, Safi, additional, Leflon, Véronique, additional, Fantin, Bruno, additional, and Lefort, Agnès, additional
- Published
- 2020
- Full Text
- View/download PDF
32. Metagenomic Characterization of Gut Microbiota of Carriers of Extended-Spectrum Beta-Lactamase or Carbapenemase-Producing Enterobacteriaceae Following Treatment with Oral Antibiotics and Fecal Microbiota Transplantation: Results from a Multicenter Randomized Trial
- Author
-
Leo, Stefano, primary, Lazarevic, Vladimir, additional, Girard, Myriam, additional, Gaïa, Nadia, additional, Schrenzel, Jacques, additional, de Lastours, Victoire, additional, Fantin, Bruno, additional, Bonten, Marc, additional, Carmeli, Yehuda, additional, Rondinaud, Emilie, additional, Harbarth, Stephan, additional, and Huttner, Benedikt D., additional
- Published
- 2020
- Full Text
- View/download PDF
33. Different kinetics of infectious processes in vertebral osteomyelitis of pyogenic or tuberculous origin explain different timing of surgery
- Author
-
Perrineau, Ségolène, primary, Zarrouk, Virginie, additional, Zoghlami, Mohamed, additional, Allaham, Wassim, additional, Leflon-Guibout, Véronique, additional, Rousseau, Marc-Antoine, additional, and Fantin, Bruno, additional
- Published
- 2020
- Full Text
- View/download PDF
34. Activity of the combination of colistin and fosfomycin against NDM-1-producing Escherichia coli with variable levels of susceptibility to colistin and fosfomycin in a murine model of peritonitis.
- Author
-
Menestrel, Alice Le, Guerin, François, Chau, Françoise, Massias, Laurent, Benchetrit, Laura, Cattoir, Vincent, Fantin, Bruno, Lastours, Victoire de, Le Menestrel, Alice, and de Lastours, Victoire
- Subjects
FOSFOMYCIN ,COLISTIN ,ESCHERICHIA coli ,PERITONITIS ,COUNTING ,ANTIBIOTICS ,BIOLOGICAL models ,RESEARCH ,ACIDS ,ANIMAL experimentation ,RESEARCH methodology ,EVALUATION research ,HYDROLASES ,COMPARATIVE studies ,DRUG synergism ,MICE ,MICROBIAL sensitivity tests ,PHARMACODYNAMICS - Abstract
Background: Alternative treatments are needed against NDM-1-producing Escherichia coli. Colistin (COL) and fosfomycin (FOS) often remain active in vitro but selection of resistant mutants is frequent if used separately. We determined whether the combination of colistin and fosfomycin may be useful to treat infections with NDM-1-producing E. coli with varying levels of resistance.Methods: Isogenic derivatives of E. coli CFT073 with blaNDM-1 and variable levels of resistance to colistin and fosfomycin (CFT073-NDM1, CFT073-NDM1-COL and CFT073-NDM1-FOS, respectively) were used. The combination (colistin + fosfomycin) was tested in vitro and in a fatal peritonitis murine model. Mortality and bacterial loads were determined and resistant mutants detected.Results: Colistin MICs were 0.5, 16 and 0.5 mg/L and fosfomycin MICs were 1, 1 and 32 mg/L against CFT073-NDM1, CFT073-NDM1-COL and CFT073-NDM1-FOS, respectively. In time-kill curves, combining colistin with fosfomycin was synergistic and bactericidal against CFT073-NDM1 and CFT073-NDM1-FOS, with concentrations of 4× MIC (for both drugs), but not against CFT073-NDM1-COL (concentrations of colistin = 0.5× MIC), due to regrowth with fosfomycin-resistant mutants. Mice died less and bacterial counts were lower in spleen with the combination compared with monotherapy against all strains; the combination prevented selection of resistant mutants except for CFT073-NDM1-COL where fosfomycin-resistant mutants were found in all mice.Conclusions: Combining colistin and fosfomycin was beneficial in vitro and in vivo against NDM-1-producing E. coli, even with strains less susceptible to colistin and fosfomycin. However, the combination failed to prevent the emergence of fosfomycin-resistant mutants against colistin-resistant strains. Combining colistin and fosfomycin constitutes an alternative for treatment of NDM-1 E. coli, except against colistin-resistant strains. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
35. Prediction of the intestinal resistome by a three-dimensional structure-based method
- Author
-
MMB Moleculair A, Infection & Immunity, Ruppé, Etienne, Ghozlane, Amine, Tap, Julien, Pons, Nicolas, Alvarez, Anne Sophie, Maziers, Nicolas, Cuesta, Trinidad, Hernando-Amado, Sara, Clares, Irene, Martínez, Jose Luís, Coque, Teresa M., Baquero, Fernando, Lanza, Val F., Máiz, Luis, Goulenok, Tiphaine, de Lastours, Victoire, Amor, Nawal, Fantin, Bruno, Wieder, Ingrid, Andremont, Antoine, van Schaik, Willem, Rogers, Malbert, Zhang, Xinglin, Willems, Rob J.L., de Brevern, Alexandre G., Batto, Jean Michel, Blottière, Hervé M., Léonard, Pierre, Léjard, Véronique, Letur, Aline, Levenez, Florence, Weiszer, Kevin, Haimet, Florence, Doré, Joël, Kennedy, Sean P., Ehrlich, S. Dusko, MMB Moleculair A, Infection & Immunity, Ruppé, Etienne, Ghozlane, Amine, Tap, Julien, Pons, Nicolas, Alvarez, Anne Sophie, Maziers, Nicolas, Cuesta, Trinidad, Hernando-Amado, Sara, Clares, Irene, Martínez, Jose Luís, Coque, Teresa M., Baquero, Fernando, Lanza, Val F., Máiz, Luis, Goulenok, Tiphaine, de Lastours, Victoire, Amor, Nawal, Fantin, Bruno, Wieder, Ingrid, Andremont, Antoine, van Schaik, Willem, Rogers, Malbert, Zhang, Xinglin, Willems, Rob J.L., de Brevern, Alexandre G., Batto, Jean Michel, Blottière, Hervé M., Léonard, Pierre, Léjard, Véronique, Letur, Aline, Levenez, Florence, Weiszer, Kevin, Haimet, Florence, Doré, Joël, Kennedy, Sean P., and Ehrlich, S. Dusko
- Published
- 2019
36. Prediction of the intestinal resistome by a three-dimensional structure-based method
- Author
-
European Commission, Instituto de Salud Carlos III, Comunidad de Madrid, European Society of Clinical Microbiology and Infectious Diseases, Ruppé, Etienne, Ghozlane, Amine, Tap, Julien, Pons, Nicolás, Álvarez, Anne-Sophie, Maziers, Nicolás, Cuesta, Trinidad, Hernando-Amado, Sara, Clares, Irene, Martínez, José Luis, Coque, Teresa M., Baquero, Fernando, Lanza, Val F., Máiz, Luis, Goulenok, Tiphaine, Lastours, Victoire de, Amor, Nawal, Fantin, Bruno, Wieder, Ingrid, Andremont, Antoine, Schaik, Willem van, Rogers, Malbert, Zhang, Xinglin, Willems, Rob J., Brevern, Alexandre G. de, Batto, Jean-Michel, Blottière, Hervé M., Léonard, Pierre, Léjard, Véronique, Letur, Aline, Levenez, Florence, Weiszer, Kevin, Haimet, Florence, Doré, Joël, Kennedy, Sean, Ehrlich, S. Dusko, European Commission, Instituto de Salud Carlos III, Comunidad de Madrid, European Society of Clinical Microbiology and Infectious Diseases, Ruppé, Etienne, Ghozlane, Amine, Tap, Julien, Pons, Nicolás, Álvarez, Anne-Sophie, Maziers, Nicolás, Cuesta, Trinidad, Hernando-Amado, Sara, Clares, Irene, Martínez, José Luis, Coque, Teresa M., Baquero, Fernando, Lanza, Val F., Máiz, Luis, Goulenok, Tiphaine, Lastours, Victoire de, Amor, Nawal, Fantin, Bruno, Wieder, Ingrid, Andremont, Antoine, Schaik, Willem van, Rogers, Malbert, Zhang, Xinglin, Willems, Rob J., Brevern, Alexandre G. de, Batto, Jean-Michel, Blottière, Hervé M., Léonard, Pierre, Léjard, Véronique, Letur, Aline, Levenez, Florence, Weiszer, Kevin, Haimet, Florence, Doré, Joël, Kennedy, Sean, and Ehrlich, S. Dusko
- Abstract
The intestinal microbiota is considered to be a major reservoir of antibiotic resistance determinants (ARDs) that could potentially be transferred to bacterial pathogens via mobile genetic elements. Yet, this assumption is poorly supported by empirical evidence due to the distant homologies between known ARDs (mostly from culturable bacteria) and ARDs from the intestinal microbiota. Consequently, an accurate census of intestinal ARDs (that is, the intestinal resistome) has not yet been fully determined. For this purpose, we developed and validated an annotation method (called pairwise comparative modelling) on the basis of a three-dimensional structure (homology comparative modelling), leading to the prediction of 6,095 ARDs in a catalogue of 3.9 million proteins from the human intestinal microbiota. We found that the majority of predicted ARDs (pdARDs) were distantly related to known ARDs (mean amino acid identity 29.8%) and found little evidence supporting their transfer between species. According to the composition of their resistome, we were able to cluster subjects from the MetaHIT cohort (n = 663) into six resistotypes that were connected to the previously described enterotypes. Finally, we found that the relative abundance of pdARDs was positively associated with gene richness, but not when subjects were exposed to antibiotics. Altogether, our results indicate that the majority of intestinal microbiota ARDs can be considered intrinsic to the dominant commensal microbiota and that these genes are rarely shared with bacterial pathogens.
- Published
- 2019
37. Effect of a Red Blood Cell Transfusion on Biological Markers Used to Determine the Cause of Anemia: A Prospective Study
- Author
-
Froissart, Antoine, Rossi, Benjamin, Ranque, Brigitte, Jarrin, Irène, Bergmann, Jean-François, Beaune, Sébastien, Dautheville, Sandrine, Breau, Nicole, Dauvergne, Agnès, Deluche, Lauréline, Robert, Tiphaine, Gault, Nathalie, Roy, Carine, Zarrouk, Virginie, Steichen, Olivier, and Fantin, Bruno
- Published
- 2018
- Full Text
- View/download PDF
38. Autochthonous case of eosinophilic meningitis caused by angiostrongylus cantonensis, France, 2016
- Author
-
Nguyen, Yann, Rossi, Benjamin, Argy, Nicolas, Baker, Catherine, Nickel, Beatrice, Marti, Hanspeter, Zarrouk, Virginie, Houze, Sandrine, Fantin, Bruno, and Lefort, Agnes
- Subjects
Travelers -- Health aspects ,Meningitis -- Health aspects ,Type 2 diabetes -- Health aspects ,Fever -- Health aspects ,Health - Abstract
Angiostrongiylus cantonensis is a rat lungworm that has long been recognized as a cause of eosinophilic meningitis in Southeast Asia, the Pacific Islands, and the Caribbean, where it is endemic [...]
- Published
- 2017
- Full Text
- View/download PDF
39. More complications in cervical than in non-cervical spine tuberculosis
- Author
-
Pourbaix, Annabelle, primary, Zarrouk, Virginie, additional, Allaham, Wassim, additional, Leflon, Véronique, additional, Rousseau, Marc-Antoine, additional, Goutagny, Stephane, additional, Guigui, Pierre, additional, and Fantin, Bruno, additional
- Published
- 2019
- Full Text
- View/download PDF
40. 617. Efficacy of Dimercaptosuccinic Acid (DMSA), a Zinc Chelator, in Combination with Imipenem Against Metallo-β-Lactamase Producing Escherichia coli in a Murine Peritonitis Model
- Author
-
Cheminet, Geoffrey, primary, Nordmann, Patrice, additional, Chau, Francoise, additional, Kieffer, Nicolas, additional, Peoc’h, Katell, additional, Massias, Laurent, additional, de Lastours, Victoire, additional, and Fantin, Bruno, additional
- Published
- 2019
- Full Text
- View/download PDF
41. 1492. Comparison of Acute Cholangitis in Patients With or Without Cancer
- Author
-
Sokal, Aurélien, primary, Chawki, Sylvain, additional, Nguyen, Yann, additional, Sauvanet, Alain, additional, Ponsot, Philippe, additional, Fantin, Bruno, additional, and de Lastours, Victoire, additional
- Published
- 2019
- Full Text
- View/download PDF
42. 1563. Population Pharmacokinetics and Pharmacodynamics of Daily and Extended Interval Dalbavancin Dosing Regimens for Salvage Therapy of Staphylococcus aureus Endocarditis: Mechanistic Modeling of Rabbit Infection Data to Support Human Dosing Regimens
- Author
-
Farkas, Andras, primary, Yassin, Arsheena, additional, Fantin, Bruno, additional, and Lefort, Agnes, additional
- Published
- 2019
- Full Text
- View/download PDF
43. Unexpected Activity of Oral Fosfomycin against Resistant Strains of Escherichia coli in Murine Pyelonephritis
- Author
-
Pourbaix, Annabelle, primary, Guérin, François, additional, Burdet, Charles, additional, Massias, Laurent, additional, Chau, Françoise, additional, Cattoir, Vincent, additional, and Fantin, Bruno, additional
- Published
- 2019
- Full Text
- View/download PDF
44. Unexpected activity of oral fosfomycin against resistant strains ofEscherichia coliin murine pyelonephritis
- Author
-
Pourbaix, Annabelle, primary, Guérin, François, additional, Burdet, Charles, additional, Massias, Laurent, additional, Chau, Françoise, additional, Cattoir, Vincent, additional, and Fantin, Bruno, additional
- Published
- 2019
- Full Text
- View/download PDF
45. Travel-related health events and their risk factors in HIV-infected sub-Saharan migrants living in France and visiting their native country: The ANRS VIHVO cohort study
- Author
-
Pistone, Thierry, primary, Ouattara, Eric, additional, Gabillard, Delphine, additional, Lele, Nathalie, additional, Duvignaud, Alexandre, additional, Cordel, Hugues, additional, Malvy, Denis, additional, Bouchaud, Olivier, additional, Abgrall, Sophie, additional, Bentata, Michele, additional, Fantin, Bruno, additional, Goujard, Cécile, additional, Matheron, Sophie, additional, Launay, Odile, additional, Le Moing, Vincent, additional, Lortholary, Olivier, additional, Consigny, Paul- Henri, additional, Saada, Matthieu, additional, Katlama, Christine, additional, Simon, Anne, additional, Arvieux, Cédric, additional, Campa, Pauline, additional, Girard, Pierre-Marie, additional, Khuong, Marie-Aude, additional, Molina, Jean-Michel, additional, Lascoux-Combe, Caroline, additional, Rey, David, additional, Rondeau, Murielle, additional, Pialoux, Gilles, additional, Couzigou, Carine, additional, Vittecoq, Daniel, additional, Patey, Olivier, additional, Morlat, Philippe, additional, Duong, Michel, additional, and Chavanet, Pascal, additional
- Published
- 2019
- Full Text
- View/download PDF
46. Surgery is safe and effective when indicated in the acute phase of hematogenous pyogenic vertebral osteomyelitis
- Author
-
Canouï, Etienne, primary, Zarrouk, Virginie, additional, Canouï-Poitrine, Florence, additional, Desmoulin, Ugo, additional, Leflon, Véronique, additional, Allaham, Wassim, additional, de Lastours, Victoire, additional, Guigui, Pierre, additional, and Fantin, Bruno, additional
- Published
- 2019
- Full Text
- View/download PDF
47. Monoclonal gammopathies and hypergammaglobulemia in Gaucher disease: An analysis from the French Gaucher disease registry
- Author
-
Nguyen, Yann, primary, Stirnemann, Jérôme, additional, Monia, Bengherbia, additional, Yousfi, Karima, additional, Hamroun, Dalil, additional, Lautredoux, Florent, additional, Cador, Bérengère, additional, Berger, Marc, additional, Fantin, Bruno, additional, and Belmatoug, Nadia, additional
- Published
- 2019
- Full Text
- View/download PDF
48. Temocillin breakpoints in pyelonephritis: evaluation in a murine model due to ESBL-producing Escherichia coli clinical isolates
- Author
-
Alexandre, Kévin, primary, Soares, Anaïs, additional, Chau, Françoise, additional, Fantin, Bruno, additional, Caron, François, additional, and Etienne, Manuel, additional
- Published
- 2019
- Full Text
- View/download PDF
49. Characteristics of and risk factors for severe neurological deficit in patients with pyogenic vertebral osteomyelitis: A case-control study
- Author
-
Lemaignen, Adrien, Ghout, Idir, Dinh, Aurélien, Gras, Guillaume, Fantin, Bruno, Zarrouk, Virginie, Carlier, Robert, Loret, Jean-Edouard, Denes, Eric, Greder, Alix, Lescure, François-Xavier, Boutoille, David, Tattevin, Pierre, Issartel, Bertrand, Cottier, Jean-Philippe, Bernard, Louis, Bernard, Adrien, Service de Médecine Interne et Maladies Infectieuses [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Clinic Research Unit Boulogne, University Hospital A Pare, Services des maladies infectieuses [AP-HP Hôpital Raymond Poincaré, Garches], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Raymond Poincaré [AP-HP], Laboratoire de Mathématiques de Besançon (UMR 6623) (LMB), Université de Bourgogne (UB)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Dpt médecine interne [CHU Beaujon], Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Raymond Poincaré [AP-HP], Service de Neurochirurgie [CHRU Tours], Service des Maladies infectieuses et tropicales [CHU Limoges], CHU Limoges, Service des Maladies Infectieuses [CH de Versailles André Mignot], Centre Hospitalier de Versailles André Mignot (CHV), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Service des maladies infectieuses et tropicales [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Department of Infectious Diseases Clinique du Parc Lyon, Clinique Résidence du Parc, Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche en Communications et en Cybernétique de Nantes (IRCCyN), Mines Nantes (Mines Nantes)-École Centrale de Nantes (ECN)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-Université de Nantes (UN)-PRES Université Nantes Angers Le Mans (UNAM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Michel, Geneviève, Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP Hôpital Raymond Poincaré [Garches], Laboratoire de Mathématiques de Besançon, Chercheur indépendant, Hôpital Beaujon, AP-HP Hôpital Raymond Poincaré [Garches], Centre Hospitalier de Versailles (CHV), Service des maladies infectieuses et réanimation médicale, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou, Imagerie et cerveau, Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Mines Nantes (Mines Nantes)-École Centrale de Nantes (ECN)-Ecole Polytechnique de l'Université de Nantes (Polytech Nantes), Centre Hospitalier Régional Universitaire de Tours ( CHRU TOURS ), Assistance publique - Hôpitaux de Paris (AP-HP)-AP-HP Hôpital Raymond Poincaré [Garches], Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ), Centre Hospitalier de Versailles André Mignot, Infection, Antimicrobiens, Modélisation, Evolution ( IAME ), Université Paris Diderot - Paris 7 ( UPD7 ) -Université Paris 13 ( UP13 ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre hospitalier universitaire de Nantes ( CHU Nantes ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou, Université de Tours-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut de Recherche en Communications et en Cybernétique de Nantes ( IRCCyN ), Mines Nantes ( Mines Nantes ) -École Centrale de Nantes ( ECN ) -Ecole Polytechnique de l'Université de Nantes ( Polytech Nantes ), and Université de Nantes ( UN ) -Université de Nantes ( UN ) -PRES Université Nantes Angers Le Mans ( UNAM ) -Centre National de la Recherche Scientifique ( CNRS )
- Subjects
Male ,medicine.medical_specialty ,Epidural abscess ,[SDV.IMM] Life Sciences [q-bio]/Immunology ,Observational Study ,03 medical and health sciences ,0302 clinical medicine ,neurologic manifestations ,Spinal cord compression ,Internal medicine ,spinal cord compression ,medicine ,Vertebral osteomyelitis ,[ SDV.IMM ] Life Sciences [q-bio]/Immunology ,Humans ,risk factors ,030212 general & internal medicine ,Retrospective Studies ,business.industry ,Osteomyelitis ,Hazard ratio ,vertebral osteomyelitis ,Case-control study ,Retrospective cohort study ,General Medicine ,Odds ratio ,Middle Aged ,Staphylococcal Infections ,medicine.disease ,3. Good health ,Surgery ,Anti-Bacterial Agents ,Treatment Outcome ,Epidural Abscess ,Case-Control Studies ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Female ,Spinal Diseases ,France ,Nervous System Diseases ,business ,030217 neurology & neurosurgery ,Follow-Up Studies ,Research Article - Abstract
Supplemental Digital Content is available in the text, Severe neurological deficit (SND) is a rare but major complication of pyogenic vertebral osteomyelitis (PVO). We aimed to determine the risk factors and the variables associated with clinical improvement for SND during PVO. This case–control study included patients without PVO-associated SND enrolled in a prospective randomized antibiotic duration study, and patients with PVO-associated SND managed in 8 French referral centers. Risk factors for SND were determined by logistic regression. Ninety-seven patients with PVO-associated SND cases, and 297 controls were included. Risk factors for SND were epidural abscess [adjusted odds ratio, aOR 8.9 (3.8–21)], cervical [aOR 8.2 (2.8–24)], and/or thoracic involvement [aOR 14.8 (5.6–39)], Staphylococcus aureus PVO [aOR 2.5 (1.1–5.3)], and C-reactive protein (CRP) >150 mg/L [aOR 4.1 (1.9–9)]. Among the 81 patients with PVO-associated SND who were evaluated at 3 months, 62% had a favorable outcome, defined as a modified Rankin score ≤ 3. No factor was found significantly associated with good outcome, whereas high Charlson index [adjusted Hazard Ratio (aHR) 0.3 (0.1–0.9)], low American Spinal Injury Association (ASIA) impairment scale at diagnosis [aHR 0.4 (0.2–0.9)], and thoracic spinal cord compression [aHR 0.2 (0.08–0.5)] were associated with poor outcome. Duration of antibiotic treatment was not associated with functional outcome. SND is more common in cervical, thoracic, and S. aureus PVO, in the presence of epidural abscess, and when CRP >150 mg/L. Although neurological deterioration occurs in 30% of patients in early follow-up, the functional outcome is quite favorable in most cases after 3 months. The precise impact of optimal surgery and/or corticosteroids therapy must be specified by further studies.
- Published
- 2017
50. More complications in cervical than in non-cervical spine tuberculosis.
- Author
-
Pourbaix, Annabelle, Zarrouk, Virginie, Allaham, Wassim, Leflon, Véronique, Rousseau, Marc-Antoine, Goutagny, Stephane, Guigui, Pierre, and Fantin, Bruno
- Subjects
SPINAL tuberculosis ,CERVICAL vertebrae ,SPINAL surgery ,DEMOGRAPHIC characteristics ,TUBERCULOSIS patients ,TERTIARY care - Abstract
Purpose: Cervical spine tuberculosis (CST) is a rare disease that may lead to severe neurological complications. The goal of the study was to compare the characteristics of patients with CST with those of patients with non-cervical spine tuberculosis (NCST). Methods: Between 1997 and 2016, we reviewed all cases of proven tuberculosis from a cohort of spine infections in a tertiary care hospital. Clinical, biological, and imaging data were collected at baseline and after treatment. Results: Fifty-one cases of spine tuberculosis were included: 14 with CST on imaging (27%) and 37 with no cervical localization. Median age was 39 y. Demographic characteristics, duration of symptoms and neurological findings of spine compression were similarly present at presentation in CST and NCST patients. On imaging, lesions were more often multifocal in CST than in NCST patients (9/14 [64%] versus 10/37 [27%], p =.014). Spinal surgery was required in 32/51 (63%) patients. At the end of follow-up (median: 20 months), cure rates were similar in CST and NCST patients but motor and/or sensitive functional sequel were more frequent in CST than NCST patients (6/14 [43%] versus 2/37 [5%], p =.003). Conclusions: Cervical involvement is present in more than a quarter of patients with spinal tuberculosis. Patients with CST had more frequent neurological sequelae than patients with NCST. This was mainly due to a more multifocal disease at presentation. Screening for cervical localization should be systematic in patients with spinal tuberculosis even in the absence of cervical symptoms. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.