Search

Your search keyword '"Faldini, C"' showing total 474 results
Start Over Author "Faldini, C" Publication Year Range Last 10 years

Refine your results

474 results on '"Faldini, C"'

31. Efficacy of using autologous cells with graft substitutes for spinal fusion surgery: A systematic review and meta‐analysis of clinical outcomes and imaging features.

Author

Salamanna, F., Contartese, D., Tedesco, G., Ruffilli, A., Manzetti, M., Viroli, G., Traversari, M., Faldini, C., and Giavaresi, G.

Subjects
SPINAL surgery, AUTOTRANSPLANTATION, CELLULAR therapy, SPINE diseases, VISUAL analog scale, SPINAL fusion
Abstract

Over the past several decades, there has been a notable increase in the total number of spinal fusion procedures worldwide. Advanced spinal fusion techniques, surgical approaches, and new alternatives in grafting materials and implants, as well as autologous cellular therapies, have been widely employed for treating spinal diseases. While the potential of cellular therapies to yield better clinical results is appealing, supportive data are needed to confirm this claim. This meta‐analysis aims to compare the radiographic and clinical outcomes between graft substitutes with autologous cell therapies and graft substitutes alone. PubMed, Scopus, Web of Science, ClinicalTrials.gov, and the Cochrane Central Register of Controlled Trials were searched for studies comparing graft substitutes with autologous cell therapies and graft substitutes alone up to February 2024. The risk of bias of the included studies was evaluated using the Downs and Black checklist. The following outcomes were extracted for comparison: fusion success, complications/adverse events, Visual Analog Scale (VAS) score, and Oswestry Disability Index (ODI) score. Thirteen studies involving 836 patients were included, with 7 studies considered for the meta‐analysis. Results indicated that the use of graft substitutes with autologous cell therapies demonstrated higher fusion success rates at 3, 6, and 12 months, lower VAS score at 6 months, and lower ODI score at 3, 6, and 12 months. The complication rate was similar between graft substitutes with autologous cell therapies and graft substitutes alone. Although the current literature remains limited, this meta‐analysis suggests that the incorporation of cellular therapies such as bone marrow and platelet derivatives with graft substitutes is associated with a higher fusion rate and significant improvements in functional status and pain following spinal fusion. Future well‐designed randomized clinical trials are needed to definitively assess the clinical effectiveness of cellular therapies in spinal fusion. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

34. Ankle Alignment Procedures

Author

Vannini, F., Mazzotti, A., Panciera, A., Bulzacki Bogucki, B. D., Giannini, S., Faldini, C., Canata, Gian Luigi, editor, d'Hooghe, Pieter, editor, Hunt, Kenneth J., editor, Kerkhoffs, Gino M.M.J., editor, and Longo, Umile Giuseppe, editor

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results