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Your search keyword '"Fahey, Ciara"' showing total 11 results
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11 results on '"Fahey, Ciara"'

2. Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest

Author

Eastwood, Glenn, primary, Nichol, Alistair D., additional, Hodgson, Carol, additional, Parke, Rachael L., additional, McGuinness, Shay, additional, Nielsen, Niklas, additional, Bernard, Stephen, additional, Skrifvars, Markus B., additional, Stub, Dion, additional, Taccone, Fabio S., additional, Archer, John, additional, Kutsogiannis, Demetrios, additional, Dankiewicz, Josef, additional, Lilja, Gisela, additional, Cronberg, Tobias, additional, Kirkegaard, Hans, additional, Capellier, Gilles, additional, Landoni, Giovanni, additional, Horn, Janneke, additional, Olasveengen, Theresa, additional, Arabi, Yaseen, additional, Chia, Yew Woon, additional, Markota, Andrej, additional, Hænggi, Matthias, additional, Wise, Matt P., additional, Grejs, Anders M., additional, Christensen, Steffen, additional, Munk-Andersen, Heidi, additional, Granfeldt, Asger, additional, Andersen, Geir Ø., additional, Qvigstad, Eirik, additional, Flaa, Arnljot, additional, Thomas, Matthew, additional, Sweet, Katie, additional, Bewley, Jeremy, additional, Bäcklund, Minna, additional, Tiainen, Marjaana, additional, Iten, Manuela, additional, Levis, Anja, additional, Peck, Leah, additional, Walsham, James, additional, Deane, Adam, additional, Ghosh, Angajendra, additional, Annoni, Filippo, additional, Chen, Yan, additional, Knight, David, additional, Lesona, Eden, additional, Tlayjeh, Haytham, additional, Svenšek, Franc, additional, McGuigan, Peter J., additional, Cole, Jade, additional, Pogson, David, additional, Hilty, Matthias P., additional, Düring, Joachim P., additional, Bailey, Michael J., additional, Paul, Eldho, additional, Ady, Bridget, additional, Ainscough, Kate, additional, Hunt, Anna, additional, Monahan, Sinéad, additional, Trapani, Tony, additional, Fahey, Ciara, additional, and Bellomo, Rinaldo, additional

Published
2023
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3. DNA methylation of the serotonin transporter gene (SLC6A4) is associated with brain function involved in processing emotional stimuli

Author

Frodl, Thomas, Szyf, Moshe, Carballedo, Angela, Ly, Victoria, Dymov, Sergiy, Vaisheva, Farida, Morris, Derek, Fahey, Ciara, Meaney, James, Gill, Michael, and Booij, Linda

Subjects
Methylation, Depression, Mental, Serotonin, Health, Psychology and mental health
Abstract

Background: The aim of the present study was to investigate the association of fMRI blood oxygen-level dependent (BOLD) reactivity with the level of epigenetic methylation of SLC6A4 in blood DNA from a sample of healthy participants and patients with major depressive disorder (MDD). Methods: We investigated patients with MDD and healthy controls using fMRI and an emotional attention-shifting task. We assessed site-specific DNA methylation of a previously characterized SLC6A4 region in peripheral blood DNA using pyrosequencing. Results: Our study involved 25 patients with MDD and 35 healthy controls. Activation in the anterior insula elicited by negative emotional content was significantly positively associated with the degree of SLC6A4 methylation. Significantly negative associations were observed between activation in the posterior insula and the degree of SLC6A4 methylation when judging the geometry of pictures after seeing negative in contrast to positive emotional stimuli. Healthy controls with a high degree of SLC6A4 methylation depicted significantly more activity elicited by positive stimuli in limbic regions and more activity elicited by negative stimuli in limbic as well as cognitive control regions than those with a low degree of SLC6A4 methylation. Limitations: It is impossible to measure methylation directly in the brain and thus we assessed peripheral methylation of SLC6A4. Since the association was cross-sectional, no conclusion about cause and effect can be drawn. Conclusion: Our study provides further support to the hypothesis that particular DNA methylation states that are associated with brain function during emotion processing are detectable in the periphery., Introduction Childhood adversity, such as childhood maltreatment, plays an important role in a number of multifactorial mental disorders. Recent studies reveal that certain aspects of stress-related mental disorders result from [...]

Published
2015
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5. Maximal Recruitment Open Lung Ventilation in Acute Respiratory Distress Syndrome (PHARLAP). A Phase II, Multicenter Randomized Controlled Clinical Trial

Author

Hodgson, Carol L., primary, Cooper, D. James, additional, Arabi, Yaseen, additional, King, Victoria, additional, Bersten, Andrew, additional, Bihari, Shailesh, additional, Brickell, Kathy, additional, Davies, Andrew, additional, Fahey, Ciara, additional, Fraser, John, additional, McGuinness, Shay, additional, Murray, Lynne, additional, Parke, Rachael, additional, Paul, Eldho, additional, Tuxen, David, additional, Vallance, Shirley, additional, Young, Meredith, additional, and Nichol, Alistair, additional

Published
2019
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7. Single-Nucleotide Polymorphism of the FKBP5 Gene and Childhood Maltreatment as Predictors of Structural Changes in Brain Areas Involved in Emotional Processing in Depression

Author

Tozzi, Leonardo, primary, Carballedo, Angela, additional, Wetterling, Friedrich, additional, McCarthy, Hazel, additional, O'Keane, Veronica, additional, Gill, Michael, additional, Morris, Derrek, additional, Fahey, Ciara, additional, Meaney, James, additional, and Frodl, Thomas, additional

Published
2015
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8. DNA Methylation of the Serotonin Transporter Gene in Peripheral Cells and Stress-Related Changes in Hippocampal Volume: A Study in Depressed Patients and Healthy Controls

Author

Booij, Linda, primary, Szyf, Moshe, additional, Carballedo, Angela, additional, Frey, Eva-Maria, additional, Morris, Derek, additional, Dymov, Sergiy, additional, Vaisheva, Farida, additional, Ly, Victoria, additional, Fahey, Ciara, additional, Meaney, James, additional, Gill, Michael, additional, and Frodl, Thomas, additional

Published
2015
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11. Single-Nucleotide Polymorphism of the FKBP5 Gene and Childhood Maltreatment as Predictors of Structural Changes in Brain Areas Involved in Emotional Processing in Depression

Author

Tozzi, Leonardo, Carballedo, Angela, Wetterling, Friedrich, McCarthy, Hazel, O'Keane, Veronica, Gill, Michael, Morris, Derrek, Fahey, Ciara, Meaney, James, and Frodl, Thomas

Abstract

The gene expressing the FK506 binding protein 51 (FKBP5) is involved in the regulation of glucocorticoid receptor sensitivity. The rs1360780 SNP in this gene (T allele vs C homozygous) has been found to be associated with major depressive disorder (MDD). The aim of our study was to investigate whether this polymorphism might be associated with altered brain structure and function in a cohort of 40 patients with MDD and 43 healthy controls. A functional magnetic resonance imaging (fMRI) emotional attention task was employed. Diffusion tensor imaging (DTI) was also conducted, extracting mean diffusivity (MD) and fractional anisotropy (FA) from brain areas that showed functional differences between patients expressing the two alleles of the rs1360780 SNP. Finally, the effect of the interaction of childhood adversity as measured by the Childhood trauma Questionnaire (CTQ) and rs1360780 allele status was analyzed in relation to DTI measures using a general linear model. All results presented are family-wise error (FWE) corrected. Functional interactions were found between genotype and diagnosis (p<0.01). Patients carrying the high-risk allele, compared with patients not carrying it, showed reduced activity in the rolandic operculum, Heschl gyrus, insula, parahippocampal gyrus, posterior cingulate cortex, inferior frontal gyrus (p<0.05 for all measures); and increased MD and reduced FA measures in many of these regions (p<0.05). An interaction between CTQ scores and allele status was associated with DTI changes in the insula, rolandic operculum, and inferior frontal gyrus. Here, the presence of both the high-risk allele and higher CTQ scores was associated with higher MD and lower FA values (p<0.05). In conclusion, MDD patients expressing the T allele of rs1360780, compared with C homozygous patients, exhibit functional and structural differences in areas involved in emotional perception and inhibition. The interaction between the T allele and childhood maltreatment explained our structural findings in these regions, suggesting that their altered maturation and function might be influenced by early chronic stress in the presence of this genetic trait.

Published
2016
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