1. The relationship of single-strand breaks in DNA to breast cancer risk and to tissue concentrations of oestrogens.
- Author
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Sahadevan M, Lee O, Muzzio M, Phan B, Jacobs L, Khouri N, Wang J, Hu H, Stearns V, and Chatterton RT
- Subjects
- Adult, Breast Density, Breast Neoplasms diagnosis, DNA Damage, DNA Repair Enzymes analysis, Estrogens, Catechol analysis, Female, Humans, Middle Aged, Risk, Breast Neoplasms genetics, DNA Breaks, Single-Stranded, Estrogens analysis
- Abstract
Context: Clinical study of breast cancer patients in Chicago, IL, USA., Objective: Ascertain the utility of measurements of single-strand breaks (SSB) in DNA for assessment of breast cancer risk., Methods: Fine-needle aspirates of the breast, SSB by nick translation, percent breast density (PBD), Gail model risk, cumulative methylation index (CMI), enzymes of DNA repair and tissue antioxidants., Results: DNA repair enzymes and 4-hydroxyestradiol were negatively associated with SSB; CMI and PBD were positively associated., Conclusions: Quantitative measurement of SSBs by this procedure indicates the relative number of SSBs and is related to promoter methylation, antioxidant availability and percent breast density.
- Published
- 2017
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