Search

Your search keyword '"Esquerré, Diane"' showing total 131 results
Start Over Author "Esquerré, Diane" Publication Year Range Last 10 years
131 results on '"Esquerré, Diane"'

3. Combined QTL and selective sweep mappings with coding SNP annotation and cis-eQTL analysis revealed PARK2 and JAG2 as new candidate genes for adiposity regulation.

Author

Roux, Pierre-François, Boitard, Simon, Blum, Yuna, Parks, Brian, Montagner, Alexandra, Mouisel, Etienne, Djari, Anis, Esquerré, Diane, Désert, Colette, Boutin, Morgane, Leroux, Sophie, Lecerf, Frédéric, Le Bihan-Duval, Elisabeth, Klopp, Christophe, Servin, Bertrand, Pitel, Frédérique, Duclos, Michel, Guillou, Hervé, Lusis, Aldons, Demeure, Olivier, and Lagarrigue, Sandrine

Subjects
JAG2, PARK2, QTL, adiposity, cis-eQTLs, divergent lines, selective sweeps, Adipose Tissue, White, Adiposity, Alleles, Animals, Cell Line, Chickens, Chromosome Mapping, Genome, High-Throughput Nucleotide Sequencing, Jagged-2 Protein, Membrane Proteins, Mice, Molecular Sequence Annotation, Myosins, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Sequence Analysis, DNA, Ubiquitin-Protein Ligases
Abstract

Very few causal genes have been identified by quantitative trait loci (QTL) mapping because of the large size of QTL, and most of them were identified thanks to functional links already known with the targeted phenotype. Here, we propose to combine selection signature detection, coding SNP annotation, and cis-expression QTL analyses to identify potential causal genes underlying QTL identified in divergent line designs. As a model, we chose experimental chicken lines divergently selected for only one trait, the abdominal fat weight, in which several QTL were previously mapped. Using new haplotype-based statistics exploiting the very high SNP density generated through whole-genome resequencing, we found 129 significant selective sweeps. Most of the QTL colocalized with at least one sweep, which markedly narrowed candidate region size. Some of those sweeps contained only one gene, therefore making them strong positional causal candidates with no presupposed function. We then focused on two of these QTL/sweeps. The absence of nonsynonymous SNPs in their coding regions strongly suggests the existence of causal mutations acting in cis on their expression, confirmed by cis-eQTL identification using either allele-specific expression or genetic mapping analyses. Additional expression analyses of those two genes in the chicken and mice contrasted for adiposity reinforces their link with this phenotype. This study shows for the first time the interest of combining selective sweeps mapping, coding SNP annotation and cis-eQTL analyses for identifying causative genes for a complex trait, in the context of divergent lines selected for this specific trait. Moreover, it highlights two genes, JAG2 and PARK2, as new potential negative and positive key regulators of adiposity in chicken and mice.

Published
2015

8. Multi-species annotation of transcriptome and chromatin structure in domesticated animals

Author

Foissac, Sylvain, Djebali, Sarah, Munyard, Kylie, Vialaneix, Nathalie, Rau, Andrea, Muret, Kevin, Esquerré, Diane, Zytnicki, Matthias, Derrien, Thomas, Bardou, Philippe, Blanc, Fany, Cabau, Cédric, Crisci, Elisa, Dhorne-Pollet, Sophie, Drouet, Françoise, Faraut, Thomas, Gonzalez, Ignacio, Goubil, Adeline, Lacroix-Lamandé, Sonia, Laurent, Fabrice, Marthey, Sylvain, Marti-Marimon, Maria, Momal-Leisenring, Raphaelle, Mompart, Florence, Quéré, Pascale, Robelin, David, Cristobal, Magali San, Tosser-Klopp, Gwenola, Vincent-Naulleau, Silvia, Fabre, Stéphane, Pinard-Van der Laan, Marie-Hélène, Klopp, Christophe, Tixier-Boichard, Michèle, Acloque, Hervé, Lagarrigue, Sandrine, and Giuffra, Elisabetta

Published
2019
Full Text
View/download PDF

11. Survey of allele specific expression in bovine muscle

Author

Guillocheau, Gabriel M., El Hou, Abdelmajid, Meersseman, Cédric, Esquerré, Diane, Rebours, Emmanuelle, Letaief, Rabia, Simao, Morgane, Hypolite, Nicolas, Bourneuf, Emmanuelle, Bruneau, Nicolas, Vaiman, Anne, Vander Jagt, Christy J., Chamberlain, Amanda J., and Rocha, Dominique

Published
2019
Full Text
View/download PDF

15. Analysis of Polycerate Mutants Reveals the Evolutionary Co-option of HOXD1 for Horn Patterning in Bovidae

Author

Allais-Bonnet, Aurélie, Hintermann, Aurélie, Deloche, Marie-Christine, Cornette, Raphaël, Bardou, Philippe, Naval-Sanchez, Marina, Pinton, Alain, Haruda, Ashleigh, Grohs, Cécile, Zakany, Jozsef, Bigi, Daniele, Medugorac, Ivica, Putelat, Olivier, Greyvenstein, Ockert, Hadfield, Tracy, Jemaa, Slim Ben, Bunevski, Gjoko, Menzi, Fiona, Hirter, Nathalie, Paris, Julia M, Hedges, John, Palhiere, Isabelle, Rupp, Rachel, Lenstra, Johannes A, Gidney, Louisa, Lesur, Joséphine, Schafberg, Renate, Stache, Michael, Wandhammer, Marie-Dominique, Arbogast, Rose-Marie, Guintard, Claude, Blin, Amandine, Boukadiri, Abdelhak, Rivière, Julie, Esquerré, Diane, Donnadieu, Cécile, Danchin-Burge, Coralie, Reich, Coralie M, Riley, David G, van Marle-Koster, Este, Cockett, Noelle, Hayes, Benjamin J, Drögemüller, Cord, Kijas, James, Pailhoux, Eric, Tosser-Klopp, Gwenola, Duboule, Denis, Capitan, Aurélien, Allais-Bonnet, Aurélie, Hintermann, Aurélie, Deloche, Marie-Christine, Cornette, Raphaël, Bardou, Philippe, Naval-Sanchez, Marina, Pinton, Alain, Haruda, Ashleigh, Grohs, Cécile, Zakany, Jozsef, Bigi, Daniele, Medugorac, Ivica, Putelat, Olivier, Greyvenstein, Ockert, Hadfield, Tracy, Jemaa, Slim Ben, Bunevski, Gjoko, Menzi, Fiona, Hirter, Nathalie, Paris, Julia M, Hedges, John, Palhiere, Isabelle, Rupp, Rachel, Lenstra, Johannes A, Gidney, Louisa, Lesur, Joséphine, Schafberg, Renate, Stache, Michael, Wandhammer, Marie-Dominique, Arbogast, Rose-Marie, Guintard, Claude, Blin, Amandine, Boukadiri, Abdelhak, Rivière, Julie, Esquerré, Diane, Donnadieu, Cécile, Danchin-Burge, Coralie, Reich, Coralie M, Riley, David G, van Marle-Koster, Este, Cockett, Noelle, Hayes, Benjamin J, Drögemüller, Cord, Kijas, James, Pailhoux, Eric, Tosser-Klopp, Gwenola, Duboule, Denis, and Capitan, Aurélien

Published
2021

16. Analysis of Polycerate Mutants Reveals the Evolutionary Co-option of HOXD1 for Horn Patterning in Bovidae

Author

Allais-Bonnet, Aurélie, primary, Hintermann, Aurélie, additional, Deloche, Marie-Christine, additional, Cornette, Raphaël, additional, Bardou, Philippe, additional, Naval-Sanchez, Marina, additional, Pinton, Alain, additional, Haruda, Ashleigh, additional, Grohs, Cécile, additional, Zakany, Jozsef, additional, Bigi, Daniele, additional, Medugorac, Ivica, additional, Putelat, Olivier, additional, Greyvenstein, Ockert, additional, Hadfield, Tracy, additional, Jemaa, Slim Ben, additional, Bunevski, Gjoko, additional, Menzi, Fiona, additional, Hirter, Nathalie, additional, Paris, Julia M, additional, Hedges, John, additional, Palhiere, Isabelle, additional, Rupp, Rachel, additional, Lenstra, Johannes A, additional, Gidney, Louisa, additional, Lesur, Joséphine, additional, Schafberg, Renate, additional, Stache, Michael, additional, Wandhammer, Marie-Dominique, additional, Arbogast, Rose-Marie, additional, Guintard, Claude, additional, Blin, Amandine, additional, Boukadiri, Abdelhak, additional, Rivière, Julie, additional, Esquerré, Diane, additional, Donnadieu, Cécile, additional, Danchin-Burge, Coralie, additional, Reich, Coralie M, additional, Riley, David G, additional, Marle-Koster, Este van, additional, Cockett, Noelle, additional, Hayes, Benjamin J, additional, Drögemüller, Cord, additional, Kijas, James, additional, Pailhoux, Eric, additional, Tosser-Klopp, Gwenola, additional, Duboule, Denis, additional, and Capitan, Aurélien, additional

Published
2021
Full Text
View/download PDF

17. Analysis of Polycerate Mutants Reveals the Evolutionary Co-option of HOXD1 to Determine the Number and Topology of Horns in Bovidae

Author

Allais-Bonnet, Aurélie, primary, Hintermann, Aurélie, additional, Deloche, Marie-Christine, additional, Cornette, Raphaël, additional, Bardou, Philippe, additional, Naval-Sanchez, Marina, additional, Pinton, Alain, additional, Haruda, Ashleigh, additional, Grohs, Cécile, additional, Zakany, Jozsef, additional, Bigi, Daniele, additional, Medugorac, Ivica, additional, Putelat, Olivier, additional, Greyvenstein, Ockert, additional, Hadfield, Tracy, additional, Ben Jemaa, Slim, additional, Bunevski, Gjoko, additional, Menzi, Fiona, additional, Hirter, Nathalie, additional, Paris, Julia M., additional, Hedges, John, additional, Palhiere, Isabelle, additional, Rupp, Rachel, additional, Lenstra, Johannes A., additional, Gidney, Louisa, additional, Lesur, Joséphine, additional, Schafberg, Renate, additional, Stache, Michael, additional, Wandhammer, Marie-Dominique, additional, Arbogast, Rose-Marie, additional, Guintard, Claude, additional, Blin, Amandine, additional, Boukadiri, Abdelhak, additional, Riviere, Julie, additional, Esquerré, Diane, additional, Donnadieu, Cécile, additional, Danchin-Burge, Coralie, additional, Reich, Coralie M, additional, Riley, David, additional, van Marle-Koster, Este, additional, Cockett, Noelle, additional, Hayes, Benjamin J., additional, Drögemüller, Cord, additional, Kijas, James, additional, Pailhoux, Eric, additional, Tosser-Klopp, Gwenola, additional, Duboule, Denis, additional, and Capitan, Aurélien, additional

Published
2020
Full Text
View/download PDF

18. Layers response to suboptimal diet through phenotypic and transcriptomic changes in four tissues

Author

Jehl, Frédéric, Brenet, M., Rau, Andrea, Désert, Colette, Boutin, Morgane, Leroux, Sophie, Esquerré, Diane, Klopp, Christophe, Gourichon, David, Collin, Anne, Pitel, Frédérique, Zerjal, Tatiana, Lagarrigue, Sandrine, Physiologie, Environnement et Génétique pour l'Animal et les Systèmes d'Elevage [Rennes] (PEGASE), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT), Unité de Mathématiques et Informatique Appliquées de Toulouse (MIAT INRA), Institut National de la Recherche Agronomique (INRA), Pôle d'Expérimentation Avicole de Tours (UE PEAT), Biologie des Oiseaux et Aviculture (BOA), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), European Project: 633531,H2020,H2020-SFS-2014-2,Feed-a-Gene(2015), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), AgroParisTech-Institut National de la Recherche Agronomique (INRA), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, and Institut National de la Recherche Agronomique (INRA)-Université de Tours

Subjects
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT]
Abstract

International audience; Poultry meat and eggs are major sources of nutrients in human alimentation. The long production career of layers expose them to numerous stressors. Understanding the adaptive mechanisms is crucial to select robust animals and meet the needs of a growing human population. In this context, we compared the effects of a 15%-energy-reduced diet (LE) vs. a commercial diet (CT) in two feed-efficiency-diverging chicken lines. We first studied the effects of the LE on performances (egg mass, feed intake [FI], body weight) and body energy reserves, before investigating the molecular mechanisms at work by studying the adipose tissue, blood, hypothalamus and liver transcriptomes. The absence of differences in egg production between diets, combined to the increase in feed intake and the decrease in body weight in LE suggest an adaptation to the diet through an increase in energy input and a mobilization of body energy reserves. The birds reacted similarly to the diet in both lines, as shown by the absence of significant line×diet interactions. At the transcriptomic level, no interactions were detected. The increase in FI did not affect the liver, neither did the mobilization of body reserves for the adipose tissue. In blood, the differentially expressed genes were related to amino-acids, monosaccharides and steroid metabolisms. In the hypothalamus, the fatty acids metabolism and endocannabinoid signaling pathways were affected. We propose a mechanism involving endocannabinoids that could explain the increase in FI and therefore part of the adaptation to the low-energy diet. Work funded by ANR-13-ADAP-0014 and H2020-Feed-a-Gene projects.

Published
2019

20. MOESM1 of Multi-species annotation of transcriptome and chromatin structure in domesticated animals

Author

Foissac, Sylvain, Djebali, Sarah, Munyard, Kylie, Vialaneix, Nathalie, Rau, Andrea, Muret, Kevin, Esquerré, Diane, Zytnicki, Matthias, Derrien, Thomas, Bardou, Philippe, Blanc, Fany, Cabau, Cédric, Crisci, Elisa, Dhorne-Pollet, Sophie, Drouet, Françoise, Faraut, Thomas, Gonzalez, Ignacio, Goubil, Adeline, Lacroix-Lamandé, Sonia, Laurent, Fabrice, Marthey, Sylvain, Marti-Marimon, Maria, Raphaelle Momal-Leisenring, Mompart, Florence, Quéré, Pascale, Robelin, David, Cristobal, Magali, Tosser-Klopp, Gwenola, Vincent-Naulleau, Silvia, Fabre, Stéphane, Marie-Hélène Pinard-Van Der Laan, Klopp, Christophe, Tixier-Boichard, Michèle, Acloque, Hervé, Lagarrigue, Sandrine, and Giuffra, Elisabetta

Abstract

Additional file 1 Additional file 1: Supplementary figures (S1-S26) and tables (S1-S15).

Published
2019
Full Text
View/download PDF

21. Additional file 5: of RNA-seq analysis of hepatic gene expression of common Pekin, Muscovy, mule and hinny ducks fed ad libitum or overfed

Author

Hérault, Frédéric, Houée-Bigot, Magalie, Baéza, Elisabeth, Bouchez, Olivier, Esquerré, Diane, Klopp, Christophe, and Diot, Christian

Subjects
body regions, nervous system, fungi
Abstract

Clusters of enriched GO terms associated to differentially expressed genes defined by semantic similarity. (PDF 2017 kb)

Published
2019
Full Text
View/download PDF

22. Analysis of whole genome sequence data on a tropical admixed cattle breed, the Creole cattle of Guadeloupe

Author

Adam, Gabrièle, Esquerré, Diane, Bouchez, Olivier, Bardou, Philippe, Klopp, Christophe, Naves, Michel, Unité de Recherches Zootechniques (URZ), Institut National de la Recherche Agronomique (INRA), Génome et Transcriptome - Plateforme Génomique (GeT-PlaGe), Institut National de la Recherche Agronomique (INRA)-Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Unité de Mathématiques et Informatique Appliquées de Toulouse (MIAT INRA), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse)

Subjects
[SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [MATH]Mathematics [math], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2018

24. MOESM3 of Quantitative trait loci for resistance to Flavobacterium psychrophilum in rainbow trout: effect of the mode of infection and evidence of epistatic interactions

Author

Fraslin, Clémence, Dechamp, Nicolas, Bernard, Maria, Krieg, Francine, Hervet, Caroline, Guyomard, René, Esquerré, Diane, Barbieri, Johanna, Kuchly, Claire, Duchaud, Eric, Boudinot, Pierre, Rochat, Tatiana, Jean-François Bernardet, and Quillet, Edwige

Abstract

Additional file 3: Figure S2. Evolution of the rate of hererozygosity along chromosomes (mean values for the 24 individuals with an overall rate of heterozygosity higher than 1%). Description: Metacentric chromosomes (a): under the hypothesis of spontaneous retention of the second polar body during meiosis, the rate of heterozygosity is expected to be lower around the centromere (—) than in telomeric regions (- - - -). Acrocentric chromosomes (b): under the hypothesis of spontaneous retention of the second polar body during meiosis, the rate of heterozygosity is expected to increase along the chromosome from the centromeric region to the telomere. Data are illustrated for 15 chromosomes.

Published
2018
Full Text
View/download PDF

25. Gut microbiota composition of Turopolje pigs in outdoor production and acorn supplementation

Author

Estellé, Jordi, Massacci, Francesca Romana, Esquerré, Diane, Jardet, Deborah, Lemonnier, Gaetan, Óvilo, Cristina, Čandek-Potokar, Marjeta, Salajpal, Krešimir, Karolyi, Danijel, and EAAP

Subjects
Turopolje pig, outdoor production, acorn, gut microbiota
Abstract

The Turopolje pig is a local porcine breed originating from Croatia characterised by its rusticity and adaptation to the traditional outdoor farming system linked to local oak forests. While this once-widespread breed was almost completely replaced by industrial breeds in the second half of the 20th century, there is growing interest on promoting its production in the framework of sustainable porcine production. The objective of our study was to characterise the gut microbiota composition in 24 Turopolje pigs raised outdoor by using a conventional feed and a conventional feed supplemented with acorns. The gut microbiota composition of all pigs was determined by re-sequencing the bacterial 16S gene in an Illumina MiSeq. Bioinformatics analyses were performed by using Qiime’s open-reference OTU calling subsampled method following author’s recommendations. NMDS and PERMANOVA analyses performed by using the Vegan R package showed significant effects of diet, showing that the acorn supplementation has a relevant impact on gut microbiota, notably by reducing richness and diversity. This result was confirmed in differential abundance analysis that showed that 152 out of 1466 OTUs were significantly different between the two groups. Interestingly, the predicted microbiota metabolic functions that were differentially abundant involved fatty acid and amino-acid metabolisms. Funded by European Union’s H2020 RIA program (Grant agreement No 634476).

Published
2018

26. Livestock genome annotation: transcriptome and chromatin structure profiling in cattle, goat, chicken and pig

Author

Foissac, Sylvain, Djebali, Sarah, Munyard, Kylie, Vialaneix, Nathalie, Rau, Andrea, Muret, Kévin, Esquerré, Diane, Zytnicki, Matthias, Derrien, Thomas, Bardou, Philippe, Blanc, Fany, Cabau, Cédric, CRISCI, Elisa, Dhorne-Pollet, Sophie, Drouet, Françoise, González, Ignacio, Goubil, Adeline, Lacroix-Lamandé, Sonia, Laurent, Fabrice, Marthey, Sylvain, Marti-Marimon, Maria, Momal-Leisenring, Raphaëlle, Mompart, Florence, Quéré, Pascale, Robelin, David, San Cristobal, Magali, Tosser-Klopp, Gwenola, Vincent-Naulleau, Silvia, Fabre, Stéphane, Pinard - Van Der Laan, Marie-Helene, Klopp, Christophe, Tixier-Boichard, Michele, ACLOQUE, Hervé, Lagarrigue, Sandrine, Giuffra, Elisabetta, Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT), Curtin University [Perth], Planning and Transport Research Centre (PATREC), Unité de Mathématiques et Informatique Appliquées de Toulouse (MIAT INRA), Institut National de la Recherche Agronomique (INRA), Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Physiologie, Environnement et Génétique pour l'Animal et les Systèmes d'Elevage [Rennes] (PEGASE), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), iRCM, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), and Institut National de la Recherche Agronomique (INRA)-Université de Tours

Subjects
[SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, Livestock, Hi-C, [SDV]Life Sciences [q-bio], Functional annotation, [INFO]Computer Science [cs], ATAC-seq, RNA-seq, [MATH]Mathematics [math]
Abstract

Article publié dans BMC Biology. Disponible ici : https://prodinra.inra.fr/record/491694; Functional annotation of livestock genomes is a critical step to decipher the genotype-to-phenotype relationship underlying complex traits. As part of the Functional Annotation of Animal Genomes (FAANG) action, the FR-AgENCODE project aims at profiling the landscape of transcription (RNA-seq) and chromatin accessibility and conformation (ATAC-seq and Hi-C) in four livestock species representing ruminants (cattle, goat), monogastrics (pig) and birds (chicken), using three target samples related to metabolism (liver) and immunity (CD4+ and CD8+ T cells). Standardized protocols were applied to produce transcriptome and chromatin datasets for the four species. RNA-seq assays allowed to considerably extend the available catalog of protein-coding and non-coding transcripts. Gene expression profiles were consistent with known metabolic/immune functions and revealed differentially expressed transcripts with unknown function, including new lncRNAs in syntenic regions. The majority of ATAC-seq peaks of chromatin accessibility mapped to putative regulatory regions, with an enrichment of predicted transcription factor binding sites in differentially accessible peaks. Hi-C provided the first set of genome-wide maps of three-dimensional interactions across livestock and showed consistency with results from gene expression and chromatin accessibility in topological compartments of the genomes. We report the first multi-species and multi-assay genome annotation results obtained by a FAANG pilot project. The global consistency between gene expression and chromatin structure data in these four livestock species adds up to previous findings in model animals. Overall, these results emphasize the value of FAANG for the research on domesticated animals and strengthen the importance of future meta-analyses of the reference datasets being generated by this community on different species.

Published
2018
Full Text
View/download PDF

27. Progressive ataxia of Charolais cattle highlights a role of KIF1C in sustainable myelination

Author

Duchesne, Amandine, primary, Vaiman, Anne, additional, Frah, Magali, additional, Floriot, Sandrine, additional, Legoueix-Rodriguez, Sabrina, additional, Desmazières, Anne, additional, Fritz, Sébastien, additional, Beauvallet, Christian, additional, Albaric, Olivier, additional, Venot, Eric, additional, Bertaud, Maud, additional, Saintilan, Romain, additional, Guatteo, Raphaël, additional, Esquerré, Diane, additional, Branchu, Julien, additional, Fleming, Anaïs, additional, Brice, Alexis, additional, Darios, Frédéric, additional, Vilotte, Jean-Luc, additional, Stevanin, Giovanni, additional, Boichard, Didier, additional, and El Hachimi, Khalid Hamid, additional

Published
2018
Full Text
View/download PDF

28. Transcriptome and chromatin structure annotation of liver, CD4+ and CD8+ T cells from four livestock species

Author

Foissac, Sylvain, primary, Djebali, Sarah, additional, Munyard, Kylie, additional, Vialaneix, Nathalie, additional, Rau, Andrea, additional, Muret, Kevin, additional, Esquerré, Diane, additional, Zytnicki, Matthias, additional, Derrien, Thomas, additional, Bardou, Philippe, additional, Blanc, Fany, additional, Cabau, Cèdric, additional, Crisci, Elisa, additional, Dhorne-Pollet, Sophie, additional, Drouet, Françoise, additional, Faraut, Thomas, additional, Gonzalez, Ignacio, additional, Goubil, Adeline, additional, Lacroix-Lamandé, Sonia, additional, Laurent, Fabrice, additional, Marthey, Sylvain, additional, Marti-Marimon, Maria, additional, Momal-Leisenring, Raphaelle, additional, Mompart, Florence, additional, Quéré, Pascale, additional, Robelin, David, additional, Cristobal, Magali San, additional, Tosser-Klopp, Gwenola, additional, Vincent-Naulleau, Silvia, additional, Fabre, Stéphane, additional, der Laan, Marie-Hélène Pinard-Van, additional, Klopp, Christophe, additional, Tixier-Boichard, Michelè, additional, Acloque, Hervé, additional, Lagarrigue, Sandrine, additional, and Giuffra, Elisabetta, additional

Published
2018
Full Text
View/download PDF

29. Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health

Author

Duchesne, Amandine, Vaiman, Anne, Castille, Johan, Beauvallet, Christian, Gaignard, Pauline, Floriot, Sandrine, Rodriguez, Sabrina, Vilotte, Marthe, Boulanger, Laurent, Passet, Bruno, Albaric, Olivier, Guillaume, François, Boukadiri, Abdelhak, Richard, Laurence, Bertaud, Maud, Timsit, Edouard, Guatteo, Raphaël, Jaffrézic, Florence, Calvel, Pierre, Helary, Louise, Mahla, Rachid, Esquerré, Diane, Péchoux, Christine, Liuu, Sophie, Vallat, Jean-Michel, Boichard, Didier, Slama, Abdelhamid, Vilotte, Jean-Luc, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Hôpital Bicêtre, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Toulouse White Biotechnology (TWB), Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Recherche Agronomique (INRA), Biologie du Développement et Reproduction (BDR), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Centre de référence national neuropathies périphériques rares [CHU Limoges], CHU Limoges, University of Calgary, Biologie, Epidémiologie et analyse de risque en Santé Animale (BIOEPAR), Institut National de la Recherche Agronomique (INRA), Laboratoire d'Analyse Génétique pour les Espèces Animales (LABOGENA), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), ANR APIS-GENE Bovano ANR-14-CE19-0011, Institut National de la Recherche Agronomique (INRA)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), École nationale vétérinaire - Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Institut National de la Recherche Agronomique (INRA)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Bicêtre, Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Biologie du développement et reproduction (BDR), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT]

Subjects
Proteomics, bovin, Protein Extraction, [SDV]Life Sciences [q-bio], Artificial Gene Amplification and Extension, souris, Biochemistry, Polymerase Chain Reaction, Mitochondrial Dynamics, Phosphate Transport Proteins, Energy-Producing Organelles, Protein Metabolism, Mammals, Extraction Techniques, Animal Models, Ruminants, Mitochondrial DNA, Mitochondria, Nucleic acids, Phenotype, Experimental Organism Systems, Vertebrates, Cellular Structures and Organelles, anomalie veau tourneur, gène SLC25A46, Research Article, mice, lcsh:QH426-470, Forms of DNA, Mouse Models, Bioenergetics, Research and Analysis Methods, Mitochondrial Proteins, Polyneuropathies, Model Organisms, Bovines, Genetics, Animals, Humans, Molecular Biology Techniques, Molecular Biology, Organisms, Biology and Life Sciences, Cell Biology, DNA, lcsh:Genetics, Metabolism, Amino Acid Substitution, Amniotes, Mutation, Cattle, Mitochondrial Membrane, anomalie génétique
Abstract

Neuropathies are neurodegenerative diseases affecting humans and other mammals. Many genetic causes have been identified so far, including mutations of genes encoding proteins involved in mitochondrial dynamics. Recently, the “Turning calves syndrome”, a novel sensorimotor polyneuropathy was described in the French Rouge-des-Prés cattle breed. In the present study, we determined that this hereditary disease resulted from a single nucleotide substitution in SLC25A46, a gene encoding a protein of the mitochondrial carrier family. This mutation caused an apparent damaging amino-acid substitution. To better understand the function of this protein, we knocked out the Slc25a46 gene in a mouse model. This alteration affected not only the nervous system but also altered general metabolism, resulting in premature mortality. Based on optic microscopy examination, electron microscopy and on biochemical, metabolic and proteomic analyses, we showed that the Slc25a46 disruption caused a fusion/fission imbalance and an abnormal mitochondrial architecture that disturbed mitochondrial metabolism. These data extended the range of phenotypes associated with Slc25a46 dysfunction. Moreover, this Slc25a46 knock-out mouse model should be useful to further elucidate the role of SLC25A46 in mitochondrial dynamics., Author summary Mitochondria are essential organelles, the site of numerous biochemical reactions, with a critical role in delivering energy to cells, particularly in the nervous system. Consequently, disrupted mitochondrial function often results in neurodegenerative diseases, in humans and in other mammals. Herein, we determined that the “Turning calves syndrome”, a new hereditary sensorimotor polyneuropathy in the French Rouge-des-Prés cattle breed was due to a single substitution in SLC25A46, a gene encoding a protein of the mitochondrial carrier family. We created a mouse knock-out model and determined that disruption of this gene dramatically disturbed mitochondrial dynamics in various organs that resulted in altered metabolism and early death, indirectly confirming the gene identification in cattle. Moreover, our novel findings extended the range of phenotypes associated with polymorphisms of this gene and help to elucidate the role of SLC25A46 in mitochondrial function.

Published
2017
Full Text
View/download PDF

30. MOESM1 of Long noncoding RNA repertoire in chicken liver and adipose tissue

Author

Kévin Muret, Klopp, Christophe, Wucher, Valentin, Esquerré, Diane, Legeai, Fabrice, Lecerf, Frédéric, Désert, Colette, Boutin, Morgane, Jehl, Frédéric, Acloque, Hervé, Giuffra, Elisabetta, Djebali, Sarah, Foissac, Sylvain, Derrien, Thomas, and Lagarrigue, Sandrine

Abstract

Additional file 1: Fig. S1. Global Jaccard index for our RNA-Seq data calculated with various threshold values using the R software HTSfilter [32]. This figure shows on the left, count data for long noncoding RNAs; and on the right, count data for protein-coding genes. Count data were normalized by TMM methods [81]. For each type of gene, the data-based threshold corresponds to the red cross and red dotted line. For the long noncoding genes (left), the curve shape of the Jaccard index (that gives a threshold—at the maximum of the curve—equal to one read) is not consistent with the expected index curve shape, in contrast to the protein-coding genes (right) that behave correctly, with a maximum of approximately 32 reads.

Published
2017
Full Text
View/download PDF

31. Identification of a t(3;4)(p1.3;q1.5) translocation breakpoint in pigs using somatic cell hybrid mapping and high-resolution mate-pair sequencing

Author

Fève, Katia, Foissac, Sylvain, Pinton, Alain, Mompart, Florence, Esquerré, Diane, Faraut, Thomas, Yerle, Martine, Riquet, Juliette, Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
Swine, reciprocal translocation, lcsh:Medicine, population, Artificial Gene Amplification and Extension, Polymerase Chain Reaction, Translocation, Genetic, Database and Informatics Methods, ADAMTS Proteins, chromosome, lcsh:Science, hybridization, Mammals, Chromosome Biology, Eukaryota, Chromosome Mapping, High-Throughput Nucleotide Sequencing, Genomics, Chromosomal Aberrations, BAC cloning, adamtsl4, Vertebrates, Sequence Analysis, Autre (Sciences du Vivant), Research Article, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], isolated ectopia lentis, mutation, gene, cytogenetic, biogenesis, Bioinformatics, Research and Analysis Methods, Vector cloning, Genetics, Animals, Molecular Biology Techniques, Molecular Biology, Sequence Assembly Tools, Models, Genetic, Gene Mapping, lcsh:R, Organisms, Biology and Life Sciences, Computational Biology, Cell Biology, Genome Analysis, Chromosomes, Mammalian, Chromosomal Translocations, Amniotes, lcsh:Q, Sequence Alignment, Cloning
Abstract

International audience; Reciprocal translocations are the most frequently occurring constitutional structural rear-rangements in mammalian genomes. In phenotypically normal pigs, an incidence of 1/200 is estimated for such rearrangements. Even if constitutional translocations do not necessarily induce defects and diseases, they are responsible for significant economic losses in domestic animals due to reproduction failures. Over the last 30 years, advances in molecular and cytogenetic technologies have led to major improvements in the resolution of the characterization of translocation events. Characterization of translocation breakpoints helps to decipher the mechanisms that lead to such rearrangements and the functions of the genes that are involved in the translocation. Here, we describe the fine characterization of a reciprocal translocation t(3;4)(p1.3;q1.5) detected in a pig line. The breakpoint was identified at the base-pair level using a positional cloning and chromosome walking strategy in somatic cell hybrids that were generated from an animal that carries this translocation. We show that this translocation occurs within the ADAMTSL4 gene and results in a loss of expression in homozygous carriers. In addition, by taking this translocation as a model, we used a whole-genome next-generation mate-pair sequencing approach on pooled individuals to evaluate this strategy for high-throughput screening of structural rearrangements.

Published
2017
Full Text
View/download PDF

32. MOESM2 of Identification of copy number variation in French dairy and beef breeds using next-generation sequencing

Author

Letaief, Rabia, Rebours, Emmanuelle, Grohs, Cécile, Meersseman, Cédric, Fritz, Sébastien, Trouilh, Lidwine, Esquerré, Diane, Barbieri, Johanna, Klopp, Christophe, Philippe, Romain, Blanquet, Véronique, Boichard, Didier, Rocha, Dominique, and Mekki Boussaha

Subjects
ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS
Abstract

Additional file 2. CGH protocol. In this document, a detailed CGH protocol is provided.

Published
2017
Full Text
View/download PDF

33. Characterization of 3D genomic interactions in fetal pig muscle

Author

Marti Marimon, Maria Eugenia, Acloque, Hervé, Zytnicki, Matthias, Robelin, David, Djebali Quelen, Sarah, Villa-Vialaneix, Nathalie, Madsen, Ole, Lahbib Mansais, Yvette, Esquerré, Diane, Mompart, Florence, Yerle-Bouissou, Martine, Groenen, Martien, Foissac, Sylvain, Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Institut National de la Recherche Agronomique - INRA (FRANCE), Wageningen University & Research - WUR (NETHERLANDS), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Unité de Mathématiques et Informatique Appliquées de Toulouse (MIAT INRA), Institut National de la Recherche Agronomique (INRA), Wageningen University and Research [Wageningen] (WUR), Dynamiques Forestières dans l'Espace Rural (DYNAFOR), Institut National de la Recherche Agronomique (INRA)-École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National Polytechnique (Toulouse) (Toulouse INP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT], Wageningen University and Research Center (WUR), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Toulouse-Institut National Polytechnique (Toulouse) (Toulouse INP), and Institut National Polytechnique de Toulouse - INPT (FRANCE)

Subjects
Hi-C, [SDV]Life Sciences [q-bio], [SDV.BA]Life Sciences [q-bio]/Animal biology, Biologie animale, Biologie du développement, Nuclear architecture, Fetal development, Pig muscle, nuclear architecture, fetal development, pig muscle, CTCF, [SDV.BDD]Life Sciences [q-bio]/Development Biology
Abstract

Genome sequence alone is not sufficient to explain the overall coordination of nuclear activity in a particular tissue. The nuclear organisation and genomic long-range intra- and inter-chromosomal interactions play an important role in the regulation of gene expression and the activation of tissue- specific gene networks. Here we present an overview of the pig genome architecture in muscle at two late developmental stages. The muscle maturation process occurs between the 90th day and the end of gestation (114 days), a key period for survival at birth. To characterise this period we profiled chromatin interactions genome-wide with in situ Hi-C (High Throughput Chromosome Conformation Capture) in muscle samples collected at 90 and 110 days of gestation, specific moments where a drastic change in gene expression has been reported. About 200 million read pairs per library were generated (3 replicates per condition). This allowed: (a) the design of an experimental Hi-C protocol optimized for frozen fetal tissues, (b) the first Hi-C contact heatmaps in fetal porcine muscle cells, and (c) to profile Topologically Associated Domains (TADs) defined as genomic domains with high levels of chromatin interactions. Using the new assembly version Sus scrofa v11, we could map 82% of the Hi-C reads on the reference genome. After filtering, 49% of valid read pairs were used to infer the genomic interactions in both developmental stages. In addition, ChIP-seq experiments were performed to map the binding of the structural protein CTCF, known to regulate genome structure by promoting interactions between genes and distal enhancers. The Hi-C and ChIP-seq data were analysed in combination with the results of a previous transcriptome analysis, focusing on the hun-dreds of genes that were reported as differentially expressed during muscle maturation. We will report the observed general differences between both developmental stages in terms of transcription and structure.

Published
2017

34. Construction of whole genome interaction maps and study of correlation with gene expression level in fetal muscle cells

Author

Marti-Marimon, Maria, ACLOQUE, Hervé, Robelin, David, Zytnicki, Matthias, Djebali, Sarah, Lahbib Mansais, Yvette, Esquerré, Diane, Mompart, Florence, Yerle-Bouissou, Martine, Foissac, Sylvain, Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Unité de Mathématiques et Informatique Appliquées de Toulouse (MIAT INRA), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, correlation, [SDV]Life Sciences [q-bio], interaction, [INFO]Computer Science [cs], genetic, [MATH]Mathematics [math], genome, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2016

35. First microbial gene catalog and antibiotic resistome of rabbit gut microbiota established by metagenomic sequencing

Author

Achard, Caroline, RAMAYO CALDAS, Yuliaxis, Ghozlane, Amine, Almeida, Mathieu, Ballester, Maria, Boucher, Samuel, Chatellier, Stéphane, Chaubet, Adeline, Combes, Sylvie, Denis, Catherine, Dile, Benoit, Esquerré, Diane, Gabinaud, Beatrice, Le Normand, Bernadette, Pons, Nicolas, Ruppe, Etienne, Estellé, Jordi, Zemb, Olivier, Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, MetaGenoPolis, Institut National de la Recherche Agronomique (INRA), Center for Bioinformatics and Computational Biology, University of Delaware [Newark], LABOVET Conseil, Réseau Cristal, Clinique Vétérinaire des Marchés de Bretagne, Genomic Research Laboratory, and Geneva University Hospital (HUG)

Subjects
[SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, microbiote, antibiotic, [SDV]Life Sciences [q-bio], rabbit, [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2016

36. First rabbit gut microbial gene catalog and metagenomic insights into the resistome : links with antibiotic use

Author

Achard, Caroline, RAMAYO CALDAS, Yuliaxis, Ghozlane, Amine, Almeida, Mathieu, Boucher, Samuel, Chatellier, Stéphane, Chaubet, Adeline, Combes, Sylvie, Denis, Catherine, Dile, Benoit, Esquerré, Diane, Gabinaud, Beatrice, Le Normand, Bernadette, Pons, Nicolas, Ruppe, Etienne, Estelle Fabrellas, Jordi, Zemb, Olivier, Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, MetaGenoPolis, Institut National de la Recherche Agronomique (INRA), Center for Bioinformatics and Computational Biology, University of Delaware [Newark], LABOVET Conseil, Réseau Cristal, and Clinique Vétérinaire des Marchés de Bretagne

Subjects
resistance, [SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, antibiotic, [SDV]Life Sciences [q-bio], rabbit, microbiota, [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

37. A missense variant in the coil1A domain of the keratin 25 gene is associated with the dominant curly hair coat trait (Crd) in horse

Author

Morgenthaler, Caroline, primary, Diribarne, Mathieu, additional, Capitan, Aurélien, additional, Legendre, Rachel, additional, Saintilan, Romain, additional, Gilles, Maïlys, additional, Esquerré, Diane, additional, Juras, Rytis, additional, Khanshour, Anas, additional, Schibler, Laurent, additional, and Cothran, Gus, additional

Published
2017
Full Text
View/download PDF

38. Identification of copy number variation in French dairy and beef breeds using next-generation sequencing

Author

Letaief, Rabia, primary, Rebours, Emmanuelle, additional, Grohs, Cécile, additional, Meersseman, Cédric, additional, Fritz, Sébastien, additional, Trouilh, Lidwine, additional, Esquerré, Diane, additional, Barbieri, Johanna, additional, Klopp, Christophe, additional, Philippe, Romain, additional, Blanquet, Véronique, additional, Boichard, Didier, additional, Rocha, Dominique, additional, and Boussaha, Mekki, additional

Published
2017
Full Text
View/download PDF

39. The Effects of Weaning Methods on Gut Microbiota Composition and Horse Physiology

Author

Mach, Núria, primary, Foury, Aline, additional, Kittelmann, Sandra, additional, Reigner, Fabrice, additional, Moroldo, Marco, additional, Ballester, Maria, additional, Esquerré, Diane, additional, Rivière, Julie, additional, Sallé, Guillaume, additional, Gérard, Philippe, additional, Moisan, Marie-Pierre, additional, and Lansade, Léa, additional

Published
2017
Full Text
View/download PDF

40. Genetic variability of the activity of bidirectional promoters: a pilot study in bovine muscle

Author

Meersseman, Cédric, primary, Letaief, Rabia, additional, Léjard, Véronique, additional, Rebours, Emmanuelle, additional, Guillocheau, Gabriel, additional, Esquerré, Diane, additional, Djari, Anis, additional, Chamberlain, Amanda, additional, Vander Jagt, Christy, additional, Klopp, Christophe, additional, Boussaha, Mekki, additional, Renand, Gilles, additional, Maftah, Abderrahman, additional, Petit, Daniel, additional, and Rocha, Dominique, additional

Published
2017
Full Text
View/download PDF

41. Long noncoding RNA repertoire in chicken liver and adipose tissue

Author

Muret, Kévin, primary, Klopp, Christophe, additional, Wucher, Valentin, additional, Esquerré, Diane, additional, Legeai, Fabrice, additional, Lecerf, Frédéric, additional, Désert, Colette, additional, Boutin, Morgane, additional, Jehl, Frédéric, additional, Acloque, Hervé, additional, Giuffra, Elisabetta, additional, Djebali, Sarah, additional, Foissac, Sylvain, additional, Derrien, Thomas, additional, and Lagarrigue, Sandrine, additional

Published
2017
Full Text
View/download PDF

42. Construction of a large collection of small genome variations in French dairy and beef breeds using whole-genome sequences

Author

Boussaha, Mekki, primary, Michot, Pauline, additional, Letaief, Rabia, additional, Hozé, Chris, additional, Fritz, Sébastien, additional, Grohs, Cécile, additional, Esquerré, Diane, additional, Duchesne, Amandine, additional, Philippe, Romain, additional, Blanquet, Véronique, additional, Phocas, Florence, additional, Floriot, Sandrine, additional, Rocha, Dominique, additional, Klopp, Christophe, additional, Capitan, Aurélien, additional, and Boichard, Didier, additional

Published
2016
Full Text
View/download PDF

43. The Extent of mRNA Editing Is Limited in Chicken Liver and Adipose, but Impacted by Tissular Context, Genotype, Age, and Feeding as Exemplified with a Conserved Edited Site in COG3

Author

Roux, Pierre-François, primary, Frésard, Laure, additional, Boutin, Morgane, additional, Leroux, Sophie, additional, Klopp, Christophe, additional, Djari, Anis, additional, Esquerré, Diane, additional, Martin, Pascal G P, additional, Zerjal, Tatiana, additional, Gourichon, David, additional, Pitel, Frédérique, additional, and Lagarrigue, Sandrine, additional

Published
2016
Full Text
View/download PDF

44. Genome-Wide Study of Structural Variants in Bovine Holstein, Montbéliarde and Normande Dairy Breeds

Author

Boussaha, Mekki, primary, Esquerré, Diane, additional, Barbieri, Johanna, additional, Djari, Anis, additional, Pinton, Alain, additional, Letaief, Rabia, additional, Salin, Gérald, additional, Escudié, Frédéric, additional, Roulet, Alain, additional, Fritz, Sébastien, additional, Samson, Franck, additional, Grohs, Cécile, additional, Bernard, Maria, additional, Klopp, Christophe, additional, Boichard, Didier, additional, and Rocha, Dominique, additional

Published
2015
Full Text
View/download PDF

46. Combined QTL and Selective Sweep Mappings with Coding SNP Annotation andcis-eQTL Analysis RevealedPARK2andJAG2as New Candidate Genes for Adiposity Regulation

Author

Roux, Pierre-François, primary, Boitard, Simon, additional, Blum, Yuna, additional, Parks, Brian, additional, Montagner, Alexandra, additional, Mouisel, Etienne, additional, Djari, Anis, additional, Esquerré, Diane, additional, Désert, Colette, additional, Boutin, Morgane, additional, Leroux, Sophie, additional, Lecerf, Frédéric, additional, Le Bihan-Duval, Elisabeth, additional, Klopp, Christophe, additional, Servin, Bertrand, additional, Pitel, Frédérique, additional, Duclos, Michel Jean, additional, Guillou, Hervé, additional, Lusis, Aldons J, additional, Demeure, Olivier, additional, and Lagarrigue, Sandrine, additional

Published
2015
Full Text
View/download PDF

48. Analysis of Polycerate Mutants Reveals the Evolutionary Co-option of HOXD1 for Horn Patterning in Bovidae

Author

Daniele Bigi, Fiona Menzi, Slim Ben Jemaa, Marie-Christine Deloche, Aurélien Capitan, Johannes A. Lenstra, Marina Naval-Sanchez, Ivica Medugorac, Nathalie Hirter, Gwenola Tosser-Klopp, Diane Esquerre, Coralie M. Reich, Julia M. Paris, Rose-Marie Arbogast, Amandine Blin, Abdelhak Boukadiri, Aurélie Hintermann, Julie Rivière, Denis Duboule, Raphaël Cornette, Cécile Donnadieu, Marie-Dominique Wandhammer, Gjoko Bunevski, Louisa Gidney, Michael Stache, Isabelle Palhiere, Renate Schafberg, James Kijas, Claude Guintard, Joséphine Lesur, Jozsef Zakany, Rachel Rupp, Noelle E. Cockett, John Hedges, Ashleigh Haruda, Philippe Bardou, Olivier Putelat, Tracy Hadfield, Alain Pinton, Ockert Greyvenstein, Aurélie Allais-Bonnet, Este Van Marle-Koster, Eric Pailhoux, Coralie Danchin-Burge, David G. Riley, Cécile Grohs, Benjamin J. Hayes, Cord Drögemüller, Allice, Biologie de la Reproduction, Environnement, Epigénétique & Développement (BREED), Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-École nationale vétérinaire d'Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Martin-Luther-University Halle-Wittenberg, Génétique Animale et Biologie Intégrative (GABI), Université Paris-Saclay-AgroParisTech-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Geneva [Switzerland], University of Bologna, Ludwig Maximilian University [Munich] (LMU), Archéologie d'Alsace, Archéologie et histoire ancienne : Méditerranée - Europe (ARCHIMEDE), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Texas A&M University [College Station], Utah State University (USU), Université de Carthage - University of Carthage, Ss. Cyril and Methodius University in Skopje, University of Bern, Manx Text, Manx Loaghtan Sheep Breeders (MLSBG), Utrecht University [Utrecht], Rent a Peasant, Archéozoologie, archéobotanique : sociétés, pratiques et environnements (AASPE), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Musée Zoologique de Strasbourg, Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Acquisition et Analyse de Données pour l'Histoire naturelle (2AD), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génome et Transcriptome - Plateforme Génomique ( GeT-PlaGe), Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de l'élevage (IDELE), Agriculture Victoria (AgriBio), Tshwane University of Technology [Pretoria] (TUT), Queensland Alliance for Agriculture and Food Innovation (QAAFI), University of Queensland [Brisbane], CSIRO Agriculture and Food (CSIRO), Ecole Polytechnique Fédérale de Lausanne (EPFL), Collège de France (CdF (institution)), Allais-Bonnet, Aurélie, Hintermann, Aurélie, Deloche, Marie-Christine, Cornette, Raphaël, Bardou, Philippe, Naval-Sanchez, Marina, Pinton, Alain, Haruda, Ashleigh, Grohs, Cécile, Zakany, Jozsef, Bigi, Daniele, Medugorac, Ivica, Putelat, Olivier, Greyvenstein, Ockert, Hadfield, Tracy, Jemaa, Slim Ben, Bunevski, Gjoko, Menzi, Fiona, Hirter, Nathalie, Paris, Julia M, Hedges, John, Palhiere, Isabelle, Rupp, Rachel, Lenstra, Johannes A, Gidney, Louisa, Lesur, Joséphine, Schafberg, Renate, Stache, Michael, Wandhammer, Marie-Dominique, Arbogast, Rose-Marie, Guintard, Claude, Blin, Amandine, Boukadiri, Abdelhak, Rivière, Julie, Esquerré, Diane, Donnadieu, Cécile, Danchin-Burge, Coralie, Reich, Coralie M, Riley, David G, Marle-Koster, Este van, Cockett, Noelle, Hayes, Benjamin J, Drögemüller, Cord, Kijas, Jame, Pailhoux, Eric, Tosser-Klopp, Gwenola, Duboule, Deni, Capitan, Aurélien, École nationale vétérinaire d'Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), École nationale vétérinaire - Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT], Université de Genève = University of Geneva (UNIGE), University of Bologna/Università di Bologna, Ss. Cyril and Methodius University in Skopje (UKIM), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), and Collège de France - Chaire internationale Évolution des génomes et développement

Subjects
0106 biological sciences, Male, co-option, translocation, AcademicSubjects/SCI01180, regulatory mutation, 01 natural sciences, Hox genes, Hox gene, genes, 610 Medicine & health, Bilateria, time, Horns, 0303 health sciences, biology, Ecology, 630 Agriculture, Goats, [SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, Gene Expression Regulation, Developmental, alignment, Morphogenetic field, Biological Evolution, [SDV.BDD.MOR] Life Sciences [q-bio]/Development Biology/Morphogenesis, 590 Animals (Zoology), Haploinsufficiency, transcription, Biometry, Evolution, growth, Locus (genetics), Mice, Transgenic, [SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics, 010603 evolutionary biology, 03 medical and health sciences, goat and sheep genomics, Behavior and Systematics, framework, Genetics, Animals, Allele, Gene, Molecular Biology, Discoveries, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Homeodomain Proteins, locus, Sheep, Horn (anatomy), AcademicSubjects/SCI01130, [SDV.BDD.MOR]Life Sciences [q-bio]/Development Biology/Morphogenesis, sequence, biology.organism_classification, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, Evolutionary biology, Mutation, genome-wide association, 570 Life sciences, goat and sheep genomic
Abstract

In the course of evolution, pecorans (i.e., higher ruminants) developed a remarkable diversity of osseous cranial appendages, collectively referred to as “headgear,” which likely share the same origin and genetic basis. However, the nature and function of the genetic determinants underlying their number and position remain elusive. Jacob and other rare populations of sheep and goats are characterized by polyceraty, the presence of more than two horns. Here, we characterize distinct POLYCERATE alleles in each species, both associated with defective HOXD1 function. We show that haploinsufficiency at this locus results in the splitting of horn bud primordia, likely following the abnormal extension of an initial morphogenetic field. These results highlight the key role played by this gene in headgear patterning and illustrate the evolutionary co-option of a gene involved in the early development of bilateria to properly fix the position and number of these distinctive organs of Bovidae.

Published
2021
Full Text
View/download PDF

49. Identification of a t(3;4)(p1.3;q1.5) translocation breakpoint in pigs using somatic cell hybrid mapping and high-resolution mate-pair sequencing.

Author

Fève K, Foissac S, Pinton A, Mompart F, Esquerré D, Faraut T, Yerle M, and Riquet J

Subjects
Animals, Swine, ADAMTS Proteins genetics, Chromosome Mapping, Chromosomes, Mammalian genetics, High-Throughput Nucleotide Sequencing, Models, Genetic, Translocation, Genetic
Abstract

Reciprocal translocations are the most frequently occurring constitutional structural rearrangements in mammalian genomes. In phenotypically normal pigs, an incidence of 1/200 is estimated for such rearrangements. Even if constitutional translocations do not necessarily induce defects and diseases, they are responsible for significant economic losses in domestic animals due to reproduction failures. Over the last 30 years, advances in molecular and cytogenetic technologies have led to major improvements in the resolution of the characterization of translocation events. Characterization of translocation breakpoints helps to decipher the mechanisms that lead to such rearrangements and the functions of the genes that are involved in the translocation. Here, we describe the fine characterization of a reciprocal translocation t(3;4) (p1.3;q1.5) detected in a pig line. The breakpoint was identified at the base-pair level using a positional cloning and chromosome walking strategy in somatic cell hybrids that were generated from an animal that carries this translocation. We show that this translocation occurs within the ADAMTSL4 gene and results in a loss of expression in homozygous carriers. In addition, by taking this translocation as a model, we used a whole-genome next-generation mate-pair sequencing approach on pooled individuals to evaluate this strategy for high-throughput screening of structural rearrangements.

Published
2017
Full Text
View/download PDF

50. Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health.

Author

Duchesne A, Vaiman A, Castille J, Beauvallet C, Gaignard P, Floriot S, Rodriguez S, Vilotte M, Boulanger L, Passet B, Albaric O, Guillaume F, Boukadiri A, Richard L, Bertaud M, Timsit E, Guatteo R, Jaffrézic F, Calvel P, Helary L, Mahla R, Esquerré D, Péchoux C, Liuu S, Vallat JM, Boichard D, Slama A, and Vilotte JL

Subjects
Amino Acid Substitution genetics, Animals, Cattle, Humans, Mice, Mitochondria genetics, Mitochondria pathology, Mutation, Phenotype, Polyneuropathies pathology, Polyneuropathies veterinary, Mitochondrial Dynamics genetics, Mitochondrial Proteins genetics, Phosphate Transport Proteins genetics, Polyneuropathies genetics, Proteomics
Abstract

Neuropathies are neurodegenerative diseases affecting humans and other mammals. Many genetic causes have been identified so far, including mutations of genes encoding proteins involved in mitochondrial dynamics. Recently, the "Turning calves syndrome", a novel sensorimotor polyneuropathy was described in the French Rouge-des-Prés cattle breed. In the present study, we determined that this hereditary disease resulted from a single nucleotide substitution in SLC25A46, a gene encoding a protein of the mitochondrial carrier family. This mutation caused an apparent damaging amino-acid substitution. To better understand the function of this protein, we knocked out the Slc25a46 gene in a mouse model. This alteration affected not only the nervous system but also altered general metabolism, resulting in premature mortality. Based on optic microscopy examination, electron microscopy and on biochemical, metabolic and proteomic analyses, we showed that the Slc25a46 disruption caused a fusion/fission imbalance and an abnormal mitochondrial architecture that disturbed mitochondrial metabolism. These data extended the range of phenotypes associated with Slc25a46 dysfunction. Moreover, this Slc25a46 knock-out mouse model should be useful to further elucidate the role of SLC25A46 in mitochondrial dynamics.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results