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Your search keyword '"Errasti, Andrea E."' showing total 9 results
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9 results on '"Errasti, Andrea E."'

2. Polyunsaturated fatty acids as predictors of future suicide attempt

Author

DARAY, Federico M., primary, GRENDAS, Leandro N., additional, RODANTE, Demián E., additional, ERRASTI, Andrea E., additional, CASES, Gabriel G., additional, MOIX, Claudio F., additional, UICICH, Raúl E., additional, GIMÉNEZ, María I., additional, PUPPO, Soledad, additional, FASOLINO, Gerardo H., additional, PORTELA, Alicia, additional, GALFALVY, Hanga C., additional, and SUBLETTE, M. Elizabeth, additional

Published
2021
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8. MERTK as negative regulator of human T cell activation

Author

Cabezo´n, Raquel, primary, Carrera-Silva, E Antonio, additional, Flo´rez-Grau, Georgina, additional, Errasti, Andrea E, additional, Caldero´n-Go´mez, Elisabeth, additional, Lozano, Juan Jose´, additional, Espan~a, Carolina, additional, Ricart, Elena, additional, Pane´s, Julia´n, additional, Rothlin, Carla Vanina, additional, and Beni´tez-Ribas, Daniel, additional

Published
2015
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9. MERTK as negative regulator of human T cell activation.

Author

Cabezón R, Carrera-Silva EA, Flórez-Grau G, Errasti AE, Calderón-Gómez E, Lozano JJ, España C, Ricart E, Panés J, Rothlin CV, and Benítez-Ribas D

Subjects
Antigens, Bacterial immunology, Autocrine Communication, Blood Proteins physiology, CD4-Positive T-Lymphocytes cytology, Cell Differentiation, Cell Division, Cells, Cultured, Coculture Techniques, Dendritic Cells drug effects, Dendritic Cells immunology, Dexamethasone pharmacology, Enzyme Induction drug effects, Humans, Immunologic Memory, Interferon-gamma Release Tests, Lymphocyte Culture Test, Mixed, Monocytes cytology, Protein S, T-Cell Antigen Receptor Specificity, Up-Regulation drug effects, c-Mer Tyrosine Kinase, CD4-Positive T-Lymphocytes enzymology, Dendritic Cells enzymology, Immune Tolerance physiology, Lymphocyte Activation physiology, Proto-Oncogene Proteins physiology, Receptor Protein-Tyrosine Kinases physiology
Abstract

The aim of this study was to test the hypothesis whether MERTK, which is up-regulated in human DCs treated with immunosuppressive agents, is directly involved in modulating T cell activation. MERTK is a member of the TAM family and contributes to regulating innate immune response to ACs by inhibiting DC activation in animal models. However, whether MERTK interacts directly with T cells has not been addressed. Here, we show that MERTK is highly expressed on dex-induced human tol-DCs and participates in their tolerogenic effect. Neutralization of MERTK in allogenic MLR, as well as autologous DC-T cell cultures, leads to increased T cell proliferation and IFN-γ production. Additionally, we identify a previously unrecognized noncell-autonomous regulatory function of MERTK expressed on DCs. Mer-Fc protein, used to mimic MERTK on DCs, suppresses naïve and antigen-specific memory T cell activation. This mechanism is mediated by the neutralization of the MERTK ligand PROS1. We find that MERTK and PROS1 are expressed in human T cells upon TCR activation and drive an autocrine proproliferative mechanism. Collectively, these results suggest that MERTK on DCs controls T cell activation and expansion through the competition for PROS1 interaction with MERTK in the T cells. In conclusion, this report identified MERTK as a potent suppressor of T cell response., (© Society for Leukocyte Biology.)

Published
2015
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