36 results on '"Eross, B."'
Search Results
2. Polymorphisms in Transcription Factor Binding Sites and Enhancers as Pancreatic Ductal Adenocarcinoma Risk Factors
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Unal, Pelin, primary, Lu, Y., additional, Aoki, M., additional, Chammas, R., additional, Gazouli, M., additional, Theodoropoulos, G., additional, van Eijck, C., additional, Bijlsma, M., additional, Dijk, F., additional, Bueno-de-Mesquita, B., additional, Kupcinskas, J., additional, Kiudelis, V., additional, Kreivenaite, E., additional, Kondrackiene, J., additional, Malecka-Wojciesko, E., additional, Talar-Wojnarowska, R., additional, Kapszewicz, M., additional, Hegyi, P., additional, Szentesi, A., additional, Eross, B., additional, Bunduc, S., additional, Mohelnikova-Duchonova, B., additional, Soucek, P., additional, Hlavac, V., additional, Oliverius, M., additional, Vodickova, L., additional, Cervena, K., additional, Hackert, T., additional, Neoptolemos, J., additional, Goetz, M., additional, Uzunoglu, F., additional, Izbicki, J., additional, Stocker, H., additional, Schöttker, B., additional, Brenner, H., additional, Perri, F., additional, Tavano, F., additional, Palmieri, O., additional, Bazzocchi, F., additional, Maiello, E., additional, Testoni, S., additional, Petrone, M., additional, Arcidiacono, P., additional, Landi, S., additional, Ermini, S., additional, Bambi, F., additional, Boggi, U., additional, Capurso, G., additional, Archibugi, L., additional, Vanella, G., additional, Cavestro, G., additional, Morelli, L., additional, Di Franco, G., additional, Milanetto, A., additional, Sperti, C., additional, Pasquali, C., additional, Basso, D., additional, Pezzilli, R., additional, Lawlor, R., additional, Capretti, G., additional, Carrara, S., additional, Campa, D., additional, and Canzian, F., additional
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- 2022
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3. Recurrent acute pancreatitis prevention by the elimination of alcohol and cigarette smoking (REAPPEAR): protocol of a randomised controlled trial and a cohort study
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Ocskay K, Juhasz M, Farkas N, Zadori N, Szako L, Szakacs Z, Szentesi A, Eross B, Miklos E, Zemplenyi A, Birkas B, Csatho A, Hartung I, Nagy T, Czopf L, Izbeki F, Gajdan L, Papp M, Czako L, Illes D, Marino M, Mirabella A, Malecka-Panas E, Zatorski H, Susak Y, Opalchuk K, Capurso G, Apadula L, Gheorghe C, Saizu I, Petersen O, De-Madaria E, Rosendahl J, Parniczky A, Hegyi P, and Hungarian Pancreatic Study Grp
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substance misuse ,preventive medicine ,pancreatic disease - Abstract
Background/objectives Acute recurrent pancreatitis (ARP) due to alcohol and/or tobacco abuse is a preventable disease which lowers quality of life and can lead to chronic pancreatitis. The REAPPEAR study aims to investigate whether a combined patient education and cessation programme for smoking and alcohol prevents ARP. Methods and analysis The REAPPEAR study consists of an international multicentre randomised controlled trial (REAPPEAR-T) testing the efficacy of a cessation programme on alcohol and smoking and a prospective cohort study (REAPPEAR-C) assessing the effects of change in alcohol consumption and smoking (irrespective of intervention). Daily smoker patients hospitalised with alcohol-induced acute pancreatitis (AP) will be enrolled. All patients will receive a standard intervention priorly to encourage alcohol and smoking cessation. Participants will be subjected to laboratory testing, measurement of blood pressure and body mass index and will provide blood, hair and urine samples for later biomarker analysis. Addiction, motivation to change, socioeconomic status and quality of life will be evaluated with questionnaires. In the trial, patients will be randomised either to the cessation programme with 3-monthly visits or to the control group with annual visits. Participants of the cessation programme will receive a brief intervention at every visit with direct feedback on their alcohol consumption based on laboratory results. The primary endpoint will be the composite of 2-year all-cause recurrence rate of AP and/or 2-year all-cause mortality. The cost-effectiveness of the cessation programme will be evaluated. An estimated 182 participants will be enrolled per group to the REAPPEAR-T with further enrolment to the cohort. Ethics and dissemination The study was approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (40394-10/2020/EuIG), all local ethical approvals are in place. Results will be disseminated at conferences and in peer-reviewed journals.
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- 2022
4. Polymorphisms in transcription factor binding sites and enhancers as pancreatic ductal adenocarcinoma risk factors
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Unal, P., Lu, Y., Aoki, M., Chammas, R., Gazouli, M., Theodoropoulos, G., van Eijck, C., Bijlsma, M., Dijk, F., Bueno-de-Mesquita, B., Kupcinskas, J., Kiudelis, V., Kreivenaite, E., Kondrackiene, J., Malecka-Wojciesko, E., Talar-Wojnarowska, R., Kapszewicz, M., Hegyi, P., Szentesi, A., Eross, B., Bunduc, S., Mohelnikova-Duchonova, B., Soucek, P., Hlavac, V., Oliverius, M., Vodickova, L., Cervena, K., Hackert, T., Neoptolemos, J., Goetz, M., Uzunoglu, F., Izbicki, J., Stocker, H., Schöttker, B., Brenner, H., Perri, F., Tavano, F., Palmieri, O., Bazzocchi, F., Maiello, E., Testoni, S., Petrone, M., Arcidiacono, P., Landi, S., Ermini, S., Bambi, F., Boggi, U., Capurso, G., Archibugi, L., Vanella, G., Cavestro, G., Morelli, L., Di Franco, G., Milanetto, A. C., Sperti, C., Pasquali, C., Basso, D., Pezzilli, R., Lawlor, R., Capretti, G., Carrara, S., Campa, D., and Canzian, F.
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Hepatology ,Endocrinology, Diabetes and Metabolism ,Gastroenterology - Published
- 2022
5. Common CASR polymorphisms do not increase chronic pancreatitis risk
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Takáts, A., primary, Berke, G., additional, Szentesi, A., additional, Farkas, G., additional, Inzbéki, F., additional, Eross, B., additional, Czakó, L., additional, Vincze, Á., additional, Hegyi, P., additional, Sahin-Tóth, M., additional, and Hegyi, E., additional
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- 2021
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6. Metabolic associated fatty liver disease is associated with a more severe acute pancreatitis: A prospective cohort analysis of 2053 cases
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Váncsa, S., primary, Sipos, Z., additional, Nagy, R., additional, Ocskay, K., additional, Juhász, F., additional, Földi, M., additional, Vincze, Á., additional, Sarlós, P., additional, Bajor, J., additional, Izbéki, F., additional, Papp, M., additional, Vitális, Z., additional, Hamvas, J., additional, Czakó, L., additional, Faluhelyi, N., additional, Farkas, O., additional, Miklós, E., additional, Mikó, A., additional, Jeno-Péter, H., additional, Macarie, M., additional, Galeev, S., additional, Maldonado, E. Ramirez, additional, Sallinen, V., additional, Török, I., additional, Mickevicius, A., additional, Eross, B., additional, Párniczky, A., additional, Szentesi, A., additional, Pár, G., additional, and Hegyi, P., additional
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- 2021
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7. Prognostic role of circulating tumor DNA in pancreatic adenocarcinoma – A meta-analysis
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Bunduc, S., primary, Gede, N., additional, Váncsa, S., additional, Lillik, V., additional, Kiss, S., additional, Dembrovsky, F., additional, Eross, B., additional, Szakács, Z., additional, Mikó, A., additional, Gheorghe, C., additional, and Hegyi, P., additional
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- 2021
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8. Does SBRT improve quality of life in advanced pancreatic ductal adenocarcinoma – A systematic review
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Koepke, M., primary, Anton, S., additional, Eross, B., additional, Szakacs, Z., additional, Belka, C., additional, Niyazi, M., additional, Mayerle, J., additional, and Beyer, G., additional
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- 2021
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9. Early occurrence of pseudocysts in acute pancreatitis – a multicenter international cohort analysis of 2275 acute pancreatitis cases
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Szakó, L., primary, Váradi, A., additional, Tinusz, B., additional, Vörhendi, N., additional, Mosztbacher, D., additional, Vincze, Á., additional, Takács, T., additional, Czakó, L., additional, Izbéki, F., additional, Gajdán, L., additional, Dunás-Varga, V., additional, Hamvas, J., additional, Papp, M., additional, Fehér, K.E., additional, Varga, M., additional, Mickevicius, A., additional, Török, I., additional, Ocskay, K., additional, Juhász, M.F., additional, Váncsa, S., additional, Faluhelyi, N., additional, Farkas, O., additional, Miseta, A., additional, Vereczkei, A., additional, Mikó, A., additional, Hegyi, P.J., additional, Szentesi, A., additional, Párniczky, A., additional, Eross, B., additional, and Hegyi, P., additional
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- 2021
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10. The role of endoscopic ultrasound (EUS) in the diagnosis and treatment of insulinoma: A systematic review of the literature
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El-Sayed, G., primary, Frim, L., additional, Franklin, J., additional, McCrudden, R., additional, Gordon, C., additional, Al-Shamma, S., additional, Kiss, S., additional, Hegyi, P., additional, Eross, B., additional, and Hegyi, P.J., additional
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- 2021
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11. Risk factors for diabetes mellitus after acute pancreatitis: a systematic review and meta-analysis
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Zahariev, O.J., Bunduc, S., Kovács, A., Demeter, D., Havelda, L., Veres, D.S., Hosszúfalusi, N., Erőss, B., Teutsch, B., Juhász, M.F., and Hegyi, P.
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- 2023
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12. PWE-176 Palliative stenting in oesophageal cancer
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John, C, Jamal, S, Gordon, C, and Eross, B
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- 2015
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13. PWE-084 Itu escalation and renal replacement therapy in decompensated liver disease – utility or futility
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Zahid, A, Choudhury, M, Eross, B, Williams, E, White, N, and Al-Shamma, S
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- 2015
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14. Fatty liver disease worsens the outcome in acute pancreatitis: a systematic review and meta-analysis
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Váncsa, S., primary, Németh, D., additional, Hegyi, P., additional, Szakacs, Z., additional, Pecsi, D., additional, Miko, A., additional, Eross, B., additional, Eros, A., additional, and Par, G., additional
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- 2020
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15. Analysis of 919 Cases of Drug-Induced Acute Pancreatitis
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Eross, B., primary, Meczker, A., additional, Hanak, L., additional, Erdosi, D., additional, Matuz, M., additional, Csupor, D., additional, Bajor, J., additional, Miko, A., additional, Szakacs, Z., additional, Dobszai, D., additional, Szapary, L., additional, and Hegyi, P., additional
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- 2020
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16. Metabolic associated fatty liver disease is associated with a more severe acute pancreatitis: a prospective cohort analysis of 2053 cases
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Vancsa, Szilard, Sipos, Z., Ocskay, K., Juhasz, F., Földi, M., Vincze, A., Sarlós, P., Bajor, J., Izbéki, F., Papp, M., Vitális, Z., Hamvas, J., Czakó, L., Faluhelyi, N., Farkas, O., Miklós, E., Mikó, A., Hegyi, P. Jenő, Macarie, M., Galeev, S., Maldonado, E. Ramirez, Sallinen, V., Török, I., Mickevicius, A., Párniczky, A., Szentesi, A., Pár, G., Nagy, R., Erőss, B., and Hegyi, P.
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- 2022
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17. Early prediction of acute necrotizing pancreatitis by artificial intelligence: A prospective cohort-analysis of 2387 cases
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Kiss, Szabolcs, Pintér, J., Molontay, R., Nagy, M., Farkas, N., Sipos, Z., Fehérvári, P., Pecze, L., Vincze, A., Takács, T., Czakó, L., Izbéki, F., Halász, A., Boros, E., Hamvas, J., Varga, M., Mickevicius, A., Faluhelyi, N., Farkas, O., Váncsa, S., Nagy, R., Bunduc, S., Hegyi, P. Jenő, Márta, K., Borka, K., Doros, A., Hosszúfalusi, N., Zubek, L., Erőss, B., Párniczky, A., Hegyi, P., Szentesi, A., Molnár, Z., and Földi, M.
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- 2022
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18. Rate of gastrointestinal bleeding among acute pancreatitis patients: A systematic review and meta-analysis
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Engh, Marie Anne, Frim, L., Veres, D., Száko, L., Vörhendi, N., Csiki, E., Hegyi, P., and Erőss, B.
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- 2022
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19. Anticoagulants decrease mortality and major complication rates in moderately severe and severe acute pancreatitis - a systematic review and meta-analysis
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Patoni, Cristina, Veres, D., Dembrovszky, F., Éliás, A., Pálinkás, D., Frim, L., Hegyi, P. Jenő, Bunduc, S., and Erőss, B.
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- 2022
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20. Association of variants of genes involved in mitochondrial metabolism with pancreatic cancer risk
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Peduzzi, G., Gentiluomo, M., Tavano, F., Arcidiacono, P.G., Ermini, S., Boggi, U., Cavestro, G.M., Capurso, G., Morelli, L., Milanetto, A.C., Pezzilli, R., Lawlor, R.T., Carrara, S., Lovecek, M., Souček, P., Vodičková, Guo, F., Hackert, T., Uzunoğlu, F.G., Gazouli, M., Párniczky, A., Kupcinskas, J., Bijlsm, M.F., Bueno-de-Mesquita, B., Vermeulen, R.C.H., van Eijck, C.H.J., Jamroziak, K., Talar-Wojnarowska, R., Greenhalf, W., Gioffreda, D., Petrone, M.C., Landi, S., Archibugi, L., Puzzono, M., Funel, N., Sperti, C., Piredda, M.L., Mohelnikova-Duchonova, B., Hlaváč, V., Gao, X., Schneider, M., Izbicki, J.R., Theodoropoulos, G., Bunduc, S., Kreivenaite, E., Busch, O.R., Małecka-Panas, E., Costello, E., Perri, F., Testoni, S.G.G., Vanella, G., Pasquali, C., Oliverius, M., H.Brenner, Loos, M., Götz, M., Georgiou, K., Erőss, B., Maiello, E., Szentes i, A., Bazzocchi, F., Basso, D., Neoptolemos, J.P., Hegyi, P., Kiudelis, V., Canzian, F., and Campa, D.
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- 2021
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21. Diagnostic criteria for acute pancreatitis should be reconsidered in patients with diabetes mellitus
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Nagy, A., Mátrai, P., Mosztbacher, D., Eross, B., Papp, M., Márta, K., Pécsi, D., Illés, D., Fehér, E., Darvasi, E., Szepes, Z., Takács, T., Sarlós, P., Hamvas, J., Gajdán, L., Izbéki, F., Vincze î, Szentesi, A., Hegyi, P., and Párniczky, A.
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- 2020
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22. Newly developing pseudocysts in acute pancreatitis are associated with the severity of acute pancreatitis and appears earlier than previously thought - Analysis of 1270 cases from a prospective cohort
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Vörhendi, N., Tinusz, B., Gede, N., Vincze î, Takács, T., Czakó, L., Izbéki, F., Gajdán, L., Dunás-Varga, V., Hamvas, J., Papp, M., Fehér, K., Varga, M., Mickevicius, A., Török, I., Ocskay, K., Juhász, F., Váncsa, S., Faluhelyi, N., Farkas, O., Miseta, A., Vereczkei, A., Mikó, A., Hegyi, P., Szentesi, A., Párniczky, A., and Eross, B.
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- 2020
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23. Hypertriglyceridemia-induced acute pancreatitis: A prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases.
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Mosztbacher, D., Hanák, L., Farkas, N., Szentesi, A., Mikó, A., Bajor, J., Sarlós, P., Czimmer, J., Vincze î, Hegyi, P., Eross, B., Takács, T., Czakó, L., Németh, B., Izbéki, F., Halász, A., Gajdán, L., Hamvas, J., Papp, M., Földi, I., Fehér, K., Varga, M., Csefkó, K., Török, I., Hunor-Pál, F., Mickevicius, A., Ramirez Maldonado, E., Sallinen, V., Novák, J., Tüzün Ince, A., Galeev, S., Bod, B., Sümegi, J., Pencik, P., Dubravcsik, Z., Illés, D., Gódi, S., Kui, B., Márta, K., Pécsi, D., Varjú, P., Szakács, Z., Darvasi, E., and Párniczky, A.
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- 2020
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24. DISAPPEAR - DIScharge of Acute Pancreatitis Patients EARlier
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Hanák, L., Márta, K., Mikó, A., Pécsi, D., Hegyi, J., Eross, B., Sarlós, P., Bajor, J., Vincze î, Gódi, S., Czimmer, J., Hágendorn, R., Farkas, N., and Hegyi, P.
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- 2020
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25. PWE-119 The safety of oesophageal endoscopic mucosal resectionfor early neoplasia in barrett’s oesophagus, experiences from a general district hospital in the uk
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Clisby, C, primary, Eross, B, additional, and Gordon, C, additional
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- 2017
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26. Effect investigation of lag time between the start of diagnostic procedure and treatment of pancreatic cancer patients: a systematic review and meta-analysis.
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Nemeth, Anna Noemi, Veres, D., Bognar, S., Imrei, M., Tarjan, D., Soti, D., Bunduc, S., Eross, B., Hegyi, P., and Márta, K.
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- 2022
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27. PWE-119 The safety of oesophageal endoscopic mucosal resectionfor early neoplasia in barrett’s oesophagus, experiences from a general district hospital in the uk
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Clisby, C, Eross, B, and Gordon, C
- Abstract
IntroductionEndoscopic mucosal resection (EMR) is a widely used technique for the management of early neoplasia withi Barrett’s oesophagus (BO). EMR is believed to be a safe procedure. However the published data regarding EMR-related complications are variable and the expertise of those performing EMR is often not disclosed. Our aim was to determine the complication rates of EMR in our patients at a tertiary referral centre in the UK.MethodWe have conducted a retrospective analysis using our electronic database for endoscopic procedures for patients with BO who underwent EMR from October 2010 to December 2016. EMR was performed by an endoscopist, expert in EMR and an endoscopist, training in EMR, in patients with neoplastic appearing lesions. Bleeding, strictures, and perforation related to EMR were reviewed as the main outcome measurements. The complication rates for the expert and trainee in EMR were analysed and compared. The complication rates were also analysed in relation to the size of the EMR.ResultsA total of 99 patients underwent 134 EMR procedures and 259 EMRs, the male/female ratio was 84%, the mean age at first EMR was 71 (SD=8.2). 24 patients underwent 2 EMR procedures, 2 patients underwent 3 EMR procedures and 2 patients underwent 4 EMR procedures. The median length of the circumferential and maximum extent of the BO segments were 3 and 4 cm respectively (interquartile range (IQR) 2–4). Complication rates for procedures were as followed: 30 day mortality post EMR was 0% (0 cases). Within 8 day hospitalisation post EMR was 5.9% (8 cases). Bleeding during the EMR procedure was 11.9% (16 cases). Bleeding post procedure with a hospital admission and blood transfusion was 0.7% (1 case). Post EMR stricture was 9.7% (13 cases) of which 4.4% (6 cases) required dilatation. There was endoscopic evidence of perforation in 1.5% (2 cases). Both patients were treated during the procedure; in both cases a CT scan with non-ionic contrast swallow excluded perforation. There was no statistically significant difference in the number of minor complication for the trainee and the expert. Most importantly there was no significant, life threatening complication in either group. The complication rates increase with the size of the EMR.ConclusionIn this moderately sized retrospective study, EMR for early neoplasia within BO was shown to be a relatively safe procedure with low complication rates. A tertiary referral centre with these numbers of EMR procedures may be a safe environment for training in EMR. Any arising complications, during or post procedure, were dealt with effectively.Disclosure of InterestNone Declared
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- 2017
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28. Genetic Polymorphisms Involved in Mitochondrial Metabolism and Pancreatic Cancer Risk
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Raffaele Pezzilli, Pavel Vodicka, Andrea Párniczky, George Theodoropoulos, Renata Talar-Wojnarowska, Paolo Giorgio Arcidiacono, Ugo Boggi, Bálint Erőss, Ewa Małecka-Panas, Martin Oliverius, Daniele Campa, Rita T. Lawlor, Faik G. Uzunoglu, Maria Chiara Petrone, Livia Archibugi, Stefania Bunduc, Edita Kreivenaite, Beatrice Mohelnikova-Duchonova, Manuel Gentiluomo, Maria Liliana Piredda, Giulia Peduzzi, Thilo Hackert, Francesco Perri, Giuseppe Vanella, Olivier R. Busch, Hermann Brenner, Pavel Soucek, John P. Neoptolemos, Martin Schneider, Sabrina Gloria Giulia Testoni, Luca Morelli, Krzysztof Jamroziak, Federico Canzian, Daniela Basso, Silvia Carrara, Maria Gazouli, Juozas Kupcinskas, Konstantinos Georgiou, Xīn Gào, Claudio Pasquali, Cosimo Sperti, Evaristo Maiello, Vytautas Kiudelis, Mara Götz, Martin Loos, Gabriele Capurso, Francesca Bazzocchi, Martin Lovecek, Bas Bueno-de-Mesquita, Viktor Hlavac, Niccola Funel, Roel Vermeulen, Maarten F. Bijlsma, Anna Caterina Milanetto, Ye Lu, Giulia Martina Cavestro, Stefano Ermini, Andrea Szentesi, Jakob R. Izbicki, William Greenhalf, Francesca Tavano, Feng Guo, Marta Puzzono, Domenica Gioffreda, Péter Hegyi, Eithne Costello, Casper H.J. van Eijck, Stefano Landi, Peduzzi, G., Gentiluomo, M., Tavano, F., Arcidiacono, P. G., Ermini, S., Vodicka, P., Boggi, U., Cavestro, G. M., Capurso, G., Morelli, L., Milanetto, A. C., Pezzilli, R., Lawlor, R. T., Carrara, S., Lovecek, M., Soucek, P., Guo, F., Hackert, T., Uzunoglu, F. G., Gazouli, M., Parniczky, A., Kupcinskas, J., Bijlsma, M. F., Bueno-De-Mesquita, B., Vermeulen, R., van Eijck, C. H. J., Jamroziak, K., Talar-Wojnarowska, R., Greenhalf, W., Gioffreda, D., Petrone, M. C., Landi, S., Archibugi, L., Puzzono, M., Funel, N., Sperti, C., Piredda, M. L., Mohelnikova-Duchonova, B., Lu, Y., Hlavac, V., Gao, X., Schneider, M., Izbicki, J. R., Theodoropoulos, G., Bunduc, S., Kreivenaite, E., Busch, O. R., Malecka-Panas, E., Costello, E., Perri, F., Giulia Testoni, S. G., Vanella, G., Pasquali, C., Oliverius, M., Brenner, H., Loos, M., Gotz, M., Georgiou, K., Eross, B., Maiello, E., Szentesi, A., Bazzocchi, F., Basso, D., Neoptolemos, J. P., Hegyi, P., Kiudelis, V., Canzian, F., Campa, D., Surgery, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, Center of Experimental and Molecular Medicine, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
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Mitochondrial DNA ,Pancreatic ductal adenocarcinoma ,Nuclear gene ,endocrine system diseases ,Epidemiology ,Biology ,SUSCEPTIBILITY ,Polymorphism, Single Nucleotide ,SDG 3 - Good Health and Well-being ,Pancreatic cancer ,medicine ,Humans ,03.02. Klinikai orvostan ,Genetic variability ,Carcinoma, Pancreatic Ductal ,Case-Control Studies ,Genetic Variation ,Genome, Mitochondrial ,Mitochondria ,Pancreatic Neoplasms ,Polymorphism ,GENOME-WIDE ASSOCIATION ,Gene ,Genetics ,Genome ,GENOME-WIDE ASSOCIATION, SUSCEPTIBILITY ,Carcinoma ,Single Nucleotide ,Metabolism ,medicine.disease ,digestive system diseases ,Mitochondrial ,Oncology ,Pancreatic Ductal - Abstract
Background: The mitochondrial metabolism has been associated with pancreatic ductal adenocarcinoma (PDAC) risk. Recent evidence also suggests the involvement of the genetic variability of the mitochondrial function in several traits involved in PDAC etiology. However, a systematic investigation of the genetic variability of mitochondrial genome (mtSNP) and of all the nuclear genes involved in its functioning (n-mtSNPs) has never been reported. Methods: We conducted a two-phase association study of mtSNPs and n-mtSNPs to assess their effect on PDAC risk. We analyzed 35,297 n-mtSNPs and 101 mtSNPs in up to 55,870 individuals (12,884 PDAC cases and 42,986 controls). In addition, we also conducted a gene-based analysis on 1,588 genes involved in mitochondrial metabolism using Multi-marker Analysis of GenoMic Annotation (MAGMA) software. Results: In the discovery phase, we identified 49 n-mtSNPs and no mtSNPs associated with PDAC risk (P < 0.05). In the second phase, none of the findings were replicated. In the gene-level analysis, we observed that three genes (TERT, SUGCT, and SURF1) involved in the mitochondrial metabolism showed an association below the Bonferroni-corrected threshold of statistical significance (P = 0.05/1588 = 3.1 × 10−5). Conclusions: Even though the mitochondrial metabolism might be involved in PDAC etiology, our results, obtained in a study with one of the largest sample sizes to date, show that neither n-mtSNPs nor mtSNPs are associated with PDAC risk. Impact: This large case–control study does not support a role of the genetic variability of the mitochondrial function in PDAC risk.
- Published
- 2021
29. Acid suppression therapy, gastrointestinal bleeding and infection in acute pancreatitis - An international cohort study
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Péter Jenő Hegyi, Áron Vincze, Alexandra Demcsák, László Gajdán, Andrey Litvin, Andra Iulia Suceveanu, Eva Pijoan Comas, Riccardo Casadei, George I Papachristou, Vincenzo Cennamo, Yu-Ting Chang, Péter Hegyi, Ionut Negoi, Carlo Ingaldi, Vitor Nunes, Adriano Quiroga Castiñeira, Lihui Deng, Orestis Ioannidis, Ernő Bóna, Milene Raquel Ramos Moreira e Sá, Juan Armando Rodriguez-Oballe, Andrea Jardi Cuadrado, József Hamvas, Judit Bajor, Alexander Schneider, Tiago Cúrdia Gonçalves, Haluk Tarik Kani, Alexandra Soós, Serge Chooklin, Marcus Hollenbach, Claudio Ricci, Marta Freitas, Isabel Miguel Salas, Michael Hirth, Cristina Tocia, Dóra Illés, Daniel de la Iglesia Garcia, Amir Gougol, Patrícia Sarlós, Marco Marino, Emőke Miklós, Qing Xia, Valentina Negoita, Mihailo Bezmarevic, Radislav Nakov, Erika Darvasi, Deniz Güney Duman, Péter Kanizsai, Laura Mastrangelo, Vasile Sandru, Andrea Párniczky, Hubert Zatorski, Andrea Szentesi, Mária Papp, Mario Pelaez-Luna, Marcel Tantau, Yliya Rabotyagova, Ferenc Izbéki, Natalia V Shirinskaya, Cristian Gheorghe, Ewa Małecka-Panas, Giedrius Barauskas, Engin Altintaş, Wei Huang, Ali Kchaou, Povilas Ignatavicius, Cezar Ciubotaru, Stefania Bunduc, Jorge Paulino Pereira, Dong Wu, Sabite Kacar, Alina Tantau, António Pedro Gomes, Svetlana Turcan, Bálint Erőss, Sorin T. Barbu, Adriana Gherbon, Georgi Minkov, Júlio Constantino, Márk Félix Juhász, Jimin Han, Serhii Chuklin, Klementina Ocskay, Mila Kovacheva-Slavova, Eugen Tcaciuc, Elio Jovine, Lilla Barbara Kincses, Ines Capunge, Gabriel Constantinescu, Bogdan Mateescu, Eugen Dumitru, Ming-Chu Chang, Andrea Soriano Rios, Márta Varga, László Czakó, Volkan Gökbulut, Alexandra Mikó, Szilárd Váncsa, Ahmed Tlili, Demcsak, Alexandra, Soos, Alexandra, Kincses, Lilla, Capunge, Ines, Minkov, Georgi, Kovacheva-Slavova, Mila, Nakov, Radislav, Wu, Dong, Huang, Wei, Xia, Qing, Deng, Lihui, Hollenbach, Marcus, Schneider, Alexander, Hirth, Michael, Ioannidis, Orestis, Vincze, Aron, Bajor, Judit, Sarlos, Patricia, Czako, Laszlo, Illes, Dora, Izbeki, Ferenc, Gajdan, Laszlo, Papp, Maria, Hamvas, Jozsef, Varga, Marta, Kanizsai, Peter, Bona, Erno, Miko, Alexandra, Vancsa, Szilard, Juhasz, Mark Felix, Ocskay, Klementina, Darvasi, Erika, Miklos, Emoke, Eross, Balint, Szentesi, Andrea, Parniczky, Andrea, Casadei, Riccardo, Ricci, Claudio, Ingaldi, Carlo, Mastrangelo, Laura, Jovine, Elio, Cennamo, Vincenzo, Marino, Marco V., Barauskas, Giedrius, Ignatavicius, Povilas, Pelaez-Luna, Mario, Rios, Andrea Soriano, Turcan, Svetlana, Tcaciuc, Eugen, Malecka-Panas, Ewa, Zatorski, Hubert, Nunes, Vitor, Gomes, Antonio, Goncalves, Tiago Curdia, Freitas, Marta, Constantino, Julio, Sa, Milene, Pereira, Jorge, Mateescu, Bogdan, Constantinescu, Gabriel, Sandru, Vasile, Negoi, Ionut, Ciubotaru, Cezar, Negoita, Valentina, Bunduc, Stefania, Gheorghe, Cristian, Barbu, Sorin, Tantau, Alina, Tantau, Marcel, Dumitru, Eugen, Suceveanu, Andra Iulia, Tocia, Cristina, Gherbon, Adriana, Litvin, Andrey, Shirinskaya, Natalia, Rabotyagova, Yliya, Bezmarevic, Mihailo, Hegyi, Peter Jeno, Han, Jimin, Rodriguez-Oballe, Juan Armando, Salas, Isabel Miguel, Comas, Eva Pijoan, de la Iglesia Garcia, Daniel, Cuadrado, Andrea Jardi, Castineira, Adriano Quiroga, Chang, Yu-Ting, Chang, Ming-Chu, Kchaou, Ali, Tlili, Ahmed, Kacar, Sabite, Gokbulut, Volkan, Duman, Deniz, Kani, Haluk Tarik, Altintas, Engin, Chooklin, Serge, Chuklin, Serhii, Gougol, Amir, Papachristou, George, Hegyi, Peter, Demcsak A., Soos A., Kincses L., Capunge I., Minkov G., Kovacheva-Slavova M., Nakov R., Wu D., Huang W., Xia Q., Deng L., Hollenbach M., Schneider A., Hirth M., Ioannidis O., Vincze A., Bajor J., Sarlos P., Czako L., Illes D., Izbeki F., Gajdan L., Papp M., Hamvas J., Varga M., Kanizsai P., Bona E., Miko A., Vancsa S., Juhasz M.F., Ocskay K., Darvasi E., Miklos E., Eross B., Szentesi A., Parniczky A., Casadei R., Ricci C., Ingaldi C., Mastrangelo L., Jovine E., Cennamo V., Marino M.V., Barauskas G., Ignatavicius P., Pelaez-Luna M., Rios A.S., Turcan S., Tcaciuc E., Malecka-Panas E., Zatorski H., Nunes V., Gomes A., Goncalves T.C., Freitas M., Constantino J., Sa M., Pereira J., Mateescu B., Constantinescu G., Sandru V., Negoi I., Ciubotaru C., Negoita V., Bunduc S., Gheorghe C., Barbu S., Tantau A., Tantau M., Dumitru E., Suceveanu A.I., Tocia C., Gherbon A., Litvin A., Shirinskaya N., Rabotyagova Y., Bezmarevic M., Hegyi P.J., Han J., Rodriguez-Oballe J.A., Salas I.M., Comas E.P., Garcia D.D.L.I., Cuadrado A.J., Castineira A.Q., Chang Y.-T., Chang M.-C., Kchaou A., Tlili A., Kacar S., Gokbulut V., Duman D., Kani H.T., Altintas E., Chooklin S., Chuklin S., Gougol A., Papachristou G., and Hegyi P.
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Male ,Endocrinology, Diabetes and Metabolism ,Gastroenterology ,Cohort Studies ,Feces ,0302 clinical medicine ,Risk Factors ,Surveys and Questionnaires ,Acid suppressing drug ,Acute pancreatitis ,Gastrointestinal bleeding ,Gastrointestinal infection ,Proton pump inhibitor ,Enterocolitis, Pseudomembranous ,Aged, 80 and over ,RISK ,ASSOCIATION ,Middle Aged ,Clostridium difficile ,CANCER ,3. Good health ,Hospitalization ,Treatment Outcome ,030220 oncology & carcinogenesis ,Acute Disease ,Female ,030211 gastroenterology & hepatology ,Gastrointestinal Hemorrhage ,Cohort study ,Adult ,medicine.medical_specialty ,GI bleeding ,medicine.drug_class ,Proton-pump inhibitor ,Infections ,PROTON-PUMP INHIBITORS ,03 medical and health sciences ,Internal medicine ,mental disorders ,medicine ,MANAGEMENT ,Humans ,DRUGS ,Acute pancreatiti ,Aged ,Retrospective Studies ,Hepatology ,Clostridioides difficile ,business.industry ,Proton Pump Inhibitors ,medicine.disease ,Pancreatitis ,Acid suppression ,business - Abstract
Background: Acid suppressing drugs (ASD) are generally used in acute pancreatitis (AP); however, large cohorts are not available to understand their efficiency and safety. Therefore, our aims were to evaluate the association between the administration of ASDs, the outcome of AP, the frequency of gastrointestinal (GI) bleeding and GI infection in patients with AP. Methods: We initiated an international survey and performed retrospective data analysis on AP patients hospitalized between January 2013 and December 2018. Results: Data of 17,422 adult patients with AP were collected from 59 centers of 23 countries. We found that 23.3% of patients received ASDs before and 86.6% during the course of AP. ASDs were prescribed to 57.6% of patients at discharge. ASD administration was associated with more severe AP and higher mortality. GI bleeding was reported in 4.7% of patients, and it was associated with pancreatitis severity, mortality and ASD therapy. Stool culture test was performed in 6.3% of the patients with 28.4% positive results. Clostridium difficile was the cause of GI infection in 60.5% of cases. Among the patients with GI infections, 28.9% received ASDs, whereas 24.1% were without any acid suppression treatment. GI infection was associated with more severe pancreatitis and higher mortality. Conclusions: Although ASD therapy is widely used, it is unlikely to have beneficial effects either on the outcome of AP or on the prevention of GI bleeding during AP. Therefore, ASD therapy should be substantially decreased in the therapeutic management of AP. (C) 2020 IAP and EPC. Published by Elsevier B.V.
- Published
- 2020
30. One third of cases of new-onset diabetic ketosis in adults are associated with ketosis-prone type 2 diabetes-A systematic review and meta-analysis.
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Kovacs A, Bunduc S, Veres DS, Palinkas D, Gagyi EB, Hegyi PJ, Eross B, Mihaly E, Hegyi P, and Hosszufalusi N
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- Adult, Humans, Autoantibodies, Diabetic Ketoacidosis epidemiology, Diabetic Ketoacidosis etiology, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2 epidemiology, Ketosis
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Aims: Ketosis-prone type 2 diabetes was defined by the World Health Organization in 2019. According to the literature, the diagnosis is based on the presence of ketosis, islet autoantibody negativity and preserved insulin secretion. Our meta-analysis assessed the prevalence and clinical characteristics of ketosis-prone type 2 diabetes among patients hospitalised with diabetic ketoacidosis (DKA) or ketosis., Methods: The systematic search was performed in five main databases as of 15 October 2021 without restrictions. We calculated the pooled prevalence of ketosis-prone type 2 diabetes (exposed group) within the diabetic population under examination, patients with ketoacidosis or ketosis, to identify the clinical characteristics, and we compared it to type 1 diabetes (the comparator group). The random effects model provided pooled estimates as prevalence, odds ratio and mean difference (MD) with 95% confidence intervals., Results: Eleven articles were eligible for meta-analysis, thus incorporating 2010 patients of various ethnic backgrounds. Among patients presenting with DKA or ketosis at the onset of diabetes, 35% (95% CI: 24%-49%) had ketosis-prone type 2 diabetes. These patients were older (MD = 11.55 years; 95% CI: 5.5-17.6) and had a significantly higher body mass index (BMI) (MD = 5.48 kg/m
2 ; 95% CI: 3.25-7.72) than those with type 1 diabetes., Conclusions: Ketosis-prone type 2 diabetes accounts for one third of DKA or ketosis at the onset of diabetes in adults. These patients are characterised by islet autoantibody negativity and preserved insulin secretion. They are older and have a higher BMI compared with type 1 diabetes. C-peptide and diabetes-related autoantibody measurement is essential to identify this subgroup among patients with ketosis at the onset of diabetes., (© 2023 The Authors. Diabetes/Metabolism Research and Reviews published by John Wiley & Sons Ltd.)- Published
- 2024
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31. Obesity paradox in older sarcopenic adults - a delay in aging: A systematic review and meta-analysis.
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Eitmann S, Matrai P, Hegyi P, Balasko M, Eross B, Dorogi K, and Petervari E
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- Humans, Aged, Obesity Paradox, Aging, Obesity, Body Composition, Sarcopenia epidemiology
- Abstract
The prognostic significance of obesity in sarcopenic adults is controversial. This systematic review and meta-analysis aimed to investigate the effect of additional obesity on health outcomes in sarcopenia. MEDLINE, EMBASE, Scopus and CENTRAL were systematically searched for studies to compare health outcomes of adults with sarcopenic obesity (SO) to those of sarcopenic non-obese (SNO) adults. We also considered the methods of assessing obesity. Of 15060 records screened, 65 papers were included (100612 participants). Older community-dwelling SO adults had 15% lower mortality risk than the SNO group (hazard ratio, HR: 0.85, 95% confidence interval 0.76, 0.94) even when obesity was assessed by measurement of body composition. Additionally, meta-regression analysis revealed a significant negative linear correlation between the age and the HR of all-cause mortality in SO vs. SNO community-dwelling adults, but not in severely ill patients. Compared with SNO, SO patients presented lower physical performance, higher risk for metabolic syndrome, but similar cognitive function, risk of falls and cardiovascular diseases. Age-related obesity, SO and later fat loss leading to SNO represent consecutive phases of biological aging. Additional obesity could worsen the health state in sarcopenia, but above 65 years SO represents a biologically earlier phase with longer life expectancy than SNO., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)
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- 2024
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32. Pancreatic family history does not predict disease progression but connotes alcohol consumption in adolescents and young adults with acute pancreatitis: Analysis of an international cohort of 2,335 patients.
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Juhász MF, Farkas N, Szentesi A, Wedrychowicz A, Nita AF, Lásztity N, Tészás A, Tokodi I, Vincze Á, Eross B, Izbéki F, Czakó L, Papp M, Hegyi P, and Párniczky A
- Abstract
Background: In pediatric acute pancreatitis (AP), a family history of pancreatic diseases is prognostic for earlier onset of recurrent AP (ARP) and chronic pancreatitis (CP). No evidence supports the same association in adult-onset pancreatitis. Age-specific reasons for familial aggregation are also unclear. We aimed to examine the prognostic role of pancreatic family history for ARP/CP and observe possible underlying mechanisms., Methods: We conducted a secondary analysis of the Hungarian Pancreatic Study Group's (HPSG) multicenter, international, prospective registry of patients with AP, both children and adults. We compared the positive family history and the negative family history of pancreatic diseases, in different age groups, and analyzed trends of accompanying factors. Chi-square and Fisher exact tests were used., Results: We found a higher rate of ARP/CP in the positive pancreatic family history group (33.7 vs. 25.9%, p = 0.018), peaking at 6-17 years. Idiopathic AP peaked in childhood in the positive family history group (75% 0-5 years) and was consistently 20-35% in the negative group. A higher rate of alcohol consumption/smoking was found in the positive groups at 12-17 years (62.5 vs. 15.8%, p = 0.013) and 18-29 years (90.9 vs. 58.1%, p = 0.049). The prevalence of diabetes and hyperlipidemia steadily rose with age in both groups., Conclusion: Positive family history most likely signifies genetic background in early childhood. During adolescence and early adulthood, alcohol consumption and smoking emerge-clinicians should be aware and turn to intervention in such cases. Contrary to current viewpoints, positive pancreatic family history is not a prognostic factor for ARP and CP in adults, so it should not be regarded that way., Competing Interests: The reviewer KM declared a shared affiliation, with no collaboration, with several of the authors MJ, NF, AS, AV, BE, PH, and AP to the handling editor at the time of the review. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Juhász, Farkas, Szentesi, Wedrychowicz, Nita, Lásztity, Tészás, Tokodi, Vincze, Eross, Izbéki, Czakó, Papp, Hegyi and Párniczky.)
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- 2022
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33. Network meta-analysis of randomized controlled trials on esophagectomies in esophageal cancer: The superiority of minimally invasive surgery.
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Szakó L, Németh D, Farkas N, Kiss S, Dömötör RZ, Engh MA, Hegyi P, Eross B, and Papp A
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- Esophagectomy adverse effects, Esophagectomy methods, Humans, Minimally Invasive Surgical Procedures adverse effects, Minimally Invasive Surgical Procedures methods, Network Meta-Analysis, Postoperative Complications epidemiology, Postoperative Complications etiology, Postoperative Complications surgery, Randomized Controlled Trials as Topic, Treatment Outcome, Esophageal Neoplasms etiology, Esophageal Neoplasms surgery, Laparoscopy
- Abstract
Background: Previous meta-analyses, with many limitations, have described the beneficial nature of minimal invasive procedures., Aim: To compare all modalities of esophagectomies to each other from the results of randomized controlled trials (RCTs) in a network meta-analysis (NMA)., Methods: We conducted a systematic search of the MEDLINE, EMBASE, Reference Citation Analysis (https://www.referencecitationanalysis.com/) and CENTRAL databases to identify RCTs according to the following population, intervention, control, outcome (commonly known as PICO): P: Patients with resectable esophageal cancer; I/C: Transthoracic, transhiatal, minimally invasive (thoracolaparoscopic), hybrid, and robot-assisted esophagectomy; O: Survival, total adverse events, adverse events in subgroups, length of hospital stay, and blood loss. We used the Bayesian approach and the random effects model. We presented the geometry of the network, results with probabilistic statements, estimated intervention effects and their 95% confidence interval (CI), and the surface under the cumulative ranking curve to rank the interventions., Results: We included 11 studies in our analysis. We found a significant difference in postoperative pulmonary infection, which favored the minimally invasive intervention compared to transthoracic surgery (risk ratio 0.49; 95%CI: 0.23 to 0.99). The operation time was significantly shorter for the transhiatal approach compared to transthoracic surgery (mean difference -85 min; 95%CI: -150 to -29), hybrid intervention (mean difference -98 min; 95%CI: -190 to -9.4), minimally invasive technique (mean difference -130 min; 95%CI: -210 to -50), and robot-assisted esophagectomy (mean difference -150 min; 95%CI: -240 to -53). Other comparisons did not yield significant differences., Conclusion: Based on our results, the implication of minimally invasive esophagectomy should be favored., Competing Interests: Conflict-of-interest statement: All authors have no conflicts of interest to declare., (©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.)
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- 2022
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34. Role of stereotactic body radiation in the enhancement of the quality of life in locally advanced pancreatic adenocarcinoma: a systematic review.
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Vornhülz M, Anton S, Eross B, Szakács Z, Hegyi P, Regel I, Belka C, Niyazi M, Mayerle J, and Beyer G
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- Adult, Aged, Aged, 80 and over, Humans, Middle Aged, Pain, Quality of Life, Pancreatic Neoplasms, Adenocarcinoma radiotherapy, Adenocarcinoma surgery, Pancreatic Neoplasms radiotherapy, Pancreatic Neoplasms surgery, Radiosurgery
- Abstract
Introduction: Up to 30% of pancreatic cancer patients initially present locally advanced (LAPC). Stereotactic body radiation therapy (SBRT) may be an additional palliative treatment option when curative resection is no longer achievable. Our systematic review aimed to assess the effect of SBRT on the quality of life in LAPC., Methods: We searched five databases until June 29th, 2021, for original articles that reported on SBRT for histologically proven LAPC in adults. Data were extracted on study characteristics, SBRT and additional therapy regimen, pain, biliary complications, nutrition, quality of life and other patient-reported outcomes. Statistical analyses were performed for population and survival data., Results: 11 case series studies comprising 292 patients with a median age of 66 (range 34-89) years were included in the final analysis. The weighted average BED2;10 (radiation biologically effective dose, equivalent dose in 2 Gy fractions) was 54 Gy, delivered in 3 to 6 fractions. The individual studies used different scales and endpoints, not allowing a meta-analysis. Pain generally appeared to be improved by SBRT. SBRT significantly reduced jaundice. Local control was achieved in 71.7% of patients. Weight loss and nausea also tended to improve after SBRT., Conclusion: SBRT of locally advanced irresectable pancreatic cancer is a promising approach for achieving local control and improving the quality of life. However, randomized controlled trials with larger cohorts are needed to assess the value of SBRT in pancreatic cancer therapy., (© 2022. The Author(s).)
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- 2022
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35. Noninvasive ventilation improves the outcome in patients with pneumonia-associated respiratory failure: Systematic review and meta-analysis.
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Ruzsics I, Matrai P, Hegyi P, Nemeth D, Tenk J, Csenkey A, Eross B, Varga G, Balasko M, Petervari E, Veres G, Sepp R, Rakonczay Z Jr, Vincze A, Garami A, and Rumbus Z
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- Adult, Hospital Mortality, Humans, Randomized Controlled Trials as Topic, Respiration, Artificial methods, Noninvasive Ventilation methods, Pneumonia complications, Pneumonia therapy, Respiratory Insufficiency etiology, Respiratory Insufficiency therapy
- Abstract
Background: Noninvasive ventilation (NIV) is beneficial in exacerbations of chronic obstructive pulmonary disease (COPD), but its effectiveness in pneumonia-associated respiratory failure is still controversial. In the current meta-analysis, we aimed to investigate whether the use of NIV before intubation in pneumonia improves the mortality and intubation rates of respiratory failure as compared to no use of NIV in adults., Methods: We searched three databases from inception to December 2019. We included studies, in which pneumonia patients were randomized initially into either NIV-treated or non-NIV-treated groups. Five full-text publications, including 121 patients, reported eligible data for statistical analysis., Results: With NIV the overall hospital mortality rate seemed lower in patients with pneumonia-associated respiratory failure, but this was not significant [odds ratio (OR) = 0.39; 95% confidence interval (CI): 0.13-1.14; P = 0.085]. In the intensive care unit, the mortality was significantly lower when NIV was applied compared to no NIV treatment (OR = 0.22; 95% CI: 0.07-0.75; P = 0.015). NIV also decreased mortality compared to no NIV in patient groups, which did not exclude patients with COPD (OR = 0.25; 95% CI: 0.08-0.74; P = 0.013). The need for intubation was significantly reduced in NIV-treated patients (OR = 0.22; 95% CI: 0.09-0.53; P = 0.001), which effect was more prominent in pneumonia patient groups not excluding patients with pre-existing COPD (OR = 0.13; 95% CI: 0.03-0.46; P = 0.002)., Conclusion: NIV markedly decreases the death rate in the intensive care unit and reduces the need for intubation in patients with pneumonia-associated respiratory failure. The beneficial effects of NIV seem more pronounced in populations that include patients with COPD. Our findings suggest that NIV should be considered in the therapeutic guidelines of pneumonia, given that future clinical trials confirm the results of our meta-analysis., Availability of Data and Materials: All data and materials generated during the current study are available from the corresponding author on reasonable request., (Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2022
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36. Development and validation of a training module on the use of acetic acid for the detection of Barrett's neoplasia.
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Chedgy FJQ, Kandiah K, Barr H, De Caestecker J, Dwerryhouse S, Eross B, Gordon C, Green S, Li A, Brown J, Longcroft-Wheaton G, and Bhandari P
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- Biopsy methods, Clinical Competence, Esophagoscopy methods, Humans, Program Development, Acetic Acid administration & dosage, Barrett Esophagus pathology, Esophagoscopy education, Esophagoscopy standards, Indicators and Reagents administration & dosage
- Abstract
Background and study aims Acetic acid chromoendoscopy (AAC) enhances the ability to correctly identify Barrett's neoplasia, and is increasingly used by both expert and nonexpert endoscopists. Despite its increasing use, there is no validated training strategy to achieve competence. The aims of our study were to develop a validated training tool in AAC-assisted lesion recognition, to assess endoscopists' baseline knowledge of AAC-assisted lesion recognition, and to evaluate the efficacy and impact of this training tool. Methods A validated assessment of 40 images and 20 videos was developed. A total of 13 endoscopists with experience of Barrett's endoscopy but no formal training in AAC were recruited to the study. Participants underwent: baseline assessment 1, online training, assessment 2, interactive seminar, assessment 3. Results Baseline assessment demonstrated a sensitivity of 83 % and a negative predictive value (NPV) of 83 %. The online training intervention significantly improved sensitivity to 95 % and NPV to 94 % ( P < 0.01). Further improvement was seen after a 1-day interactive seminar including live cases, with sensitivity increasing to 98 % and NPV to 97 %. Conclusions The data demonstrate the need for training in AAC-assisted lesion recognition as baseline performance, even by Barrett's experts, was poor. The online training and testing tool for AAC for Barrett's neoplasia was successfully developed and validated. The training intervention improved performance of endoscopists to meet ASGE PIVI standards. The training tool increases the endoscopist's degree of confidence in the use of AAC. The training tool also leads to shift in attitudes of endoscopists from Seattle protocol towards AAC-guided biopsy protocol for Barrett's surveillance., (© Georg Thieme Verlag KG Stuttgart · New York.)
- Published
- 2017
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