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35 results on '"Endo, Ginji"'

10. Characteristics of printing company workers newly diagnosed with occupational cholangiocarcinoma

Author

Kubo, Shoji, Kinoshita, Masahiko, Takemura, Shigekazu, Tanaka, Shogo, Shinkawa, Hiroji, Nishioka, Takayoshi, Hamano, Genya, Ito, Tokuji, Abue, Makoto, Aoki, Masaru, Nakagawa, Kei, Unno, Michiaki, Hijioka, Susumu, Fujiyoshi, Toshihisa, Shimizu, Yasuhiro, Mizuguchi, Toru, Shirabe, Ken, Nishie, Akihiro, Oda, Yoshinao, Takenaka, Kenji, Kobarai, Tomonari, Hisano, Terumasa, Saiura, Akio, Numao, Hiroshi, Toda, Mayura, Kuwae, Yuko, Nakanuma, Yasuni, and Endo, Ginji

Published
2014
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11. Simple and reliable method to simultaneously determine urinary 1‐ and 2‐naphthol using in situ derivatization and gas chromatography‐mass spectrometry for biological monitoring of naphthalene exposure in occupational health practice

Author

Takeuchi, Akito, primary, Nakamura, Sadao, additional, Namera, Akira, additional, Kondo, Tomoaki, additional, Onuki, Hiroyuki, additional, Yamamoto, Shinobu, additional, Okamura, Shingo, additional, Nishinoiri, Osamu, additional, Endo, Yoko, additional, Miyauchi, Hiroyuki, additional, and Endo, Ginji, additional

Published
2020
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15. Exposure to 1,2-Dichloropropane Upregulates the Expression of Activation-Induced Cytidine Deaminase (AID) in Human Cholangiocytes Co-Cultured With Macrophages.

Author

Zong, Cai, Kimura, Yusuke, Kinoshita, Kazuo, Takasu, Shigetada, Zhang, Xiao, Sakurai, Toshihiro, Sekido, Yoshitaka, Ichihara, Sahoko, Endo, Ginji, and Ichihara, Gaku

Subjects
DICHLOROPROPANE, CYTIDINE deaminase, MACROPHAGES, CARCINOGENS, CHOLANGIOCARCINOMA
Abstract

1,2-dichloropropane (1,2-DCP) was reclassified recently by IARC as a Group 1 carcinogen based on epidemiological studies on an outbreak of cholangiocarcinoma in offset-printing workers exposed to 1,2-DCP in Japan. However, the underlying mechanism of 1,2-DCP-induced cholangiocarcinoma remains obscure. A previous whole-genome mutation analysis of cholangiocarcinoma of 4 cases exposed to 1,2-DCP suggested the involvement of activation-induced cytidine deaminase (AID), based on specific signatures of mutation patterns. The objective of the present study is to determine whether exposure to 1,2-DCP induces expression of AID in human cholangiocytes. Human MMNK-1 cholangiocytes, differentiated THP-1 macrophages, and co-cultures of MMNK-1/THP-1 cells were exposed to 1,2-DCP at different concentrations and time intervals. The mRNA expression levels of AID and related genes were quantified by real-time PCR. Protein expression was measured by immunostaining. Alkaline Comet assay was performed to examine DNA damage. The results showed that 1,2-DCP alone did not change AID expression in MMNK-1 cholangiocytes. 1,2-DCP significantly increased pro-inflammatory cytokine TNF-α expression in THP-1 macrophages. TNF-α treatment upregulated expression of AID, NF-κB, and IκB in MMNK-1 cholangiocytes. SN50, a NF-κB inhibitor, significantly downregulated TNF-α-induced AID expression, suggesting the involvement of NF-κB pathway in TNF-α-induced AID expression. Exposure to 1,2-DCP significantly increased AID expression in MMNK-1 cholangiocytes co-cultured with THP-1 macrophages. Comet assay showed that 1,2-DCP-induced DNA damage in MMNK-1 cholangiocytes, as indicated by increased tail DNA% and tail moment, was enhanced when co-cultured with macrophages. The results suggest that inflammatory response of macrophages and consequent aberrant AID expression or DNA damage in the cholangiocytes underlie the mechanism of 1,2-DCP-induced cholangiocarcinoma in humans. [ABSTRACT FROM AUTHOR]

Published
2019
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22. Screening and surveillance for occupational cholangiocarcinoma in workers exposed to organic solvents

Author

Kubo, Shoji, primary, Takemura, Shigekazu, additional, Tanaka, Shogo, additional, Nishioka, Takayoshi, additional, Kinoshita, Masahiko, additional, Hamano, Genya, additional, Ito, Tokuji, additional, Yamamoto, Takatsugu, additional, Abue, Makoto, additional, Aoki, Masaru, additional, Nakagawa, Kei, additional, Hijioka, Susumu, additional, Miyamoto, Atsushi, additional, Osaki, Yukio, additional, Endo, Ginji, additional, and Kumagai, Shinji, additional

Published
2015
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28. Occupational exposure limits for cumene, 2,4‐dichlorophenoxy acetic acid, silicon carbide whisker, benzyl alcohol, and methylamine, and carcinogenicity, occupational sensitizer, and reproductive toxicant classifications.

Author

Araki, Atsuko, Azuma, Kenichi, Endo, Ginji, Endo, Yoko, Fukushima, Tetsuhito, Hara, Kunio, Harada, Koji, Hori, Hajime, Horie, Seichi, Ichiba, Masayoshi, Ichihara, Gaku, Ikeda, Masayuki, Ito, Akiyoshi, Ito, Yuki, Iwasawa, Satoko, Kakumu, Takeyasu, Kamijima, Michihiro, Karita, Kanae, Katoh, Takahiko, and Kawai, Toshio

Subjects
ACETIC acid, SILICON carbide, BENZYL alcohol, METHYLAMINES, CARCINOGENICITY
Published
2019
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30. Relationship between cumulative exposure to 1,2-dichloropropane and incidence risk of cholangiocarcinoma among offset printing workers.

Author

Shinji Kumagai, Tomotaka Sobue, Takeshi Makiuchi, Shoji Kubo, Shinichiro Uehara, Tomoshige Hayashi, Kyoko Kogawa Sato, Ginji Endo, Kumagai, Shinji, Sobue, Tomotaka, Makiuchi, Takeshi, Kubo, Shoji, Uehara, Shinichiro, Hayashi, Tomoshige, Sato, Kyoko Kogawa, and Endo, Ginji

Abstract

Objectives: This study aimed to evaluate the relationship between cumulative exposure to 1,2-dichloropropane (1,2-DCP) and incidence risk of cholangiocarcinoma among workers in the offset proof-printing section of a small printing company in Osaka, Japan.Methods: We identified 95 workers of a printing company (78 men and 17 women) who had been exposed to 1,2-DCP between 1987 and 2006, and calculated the standardised incidence ratio (SIR) of cholangiocarcinoma from 1987 to 2012. We estimated cumulative exposure to 1,2-DCP and calculated SIRs in four exposure categories. We also calculated incidence rate ratios (RRs) adjusted by sex, age, calendar year and dichloromethane (DCM) exposure for three exposure categories using Poisson regression analysis.Results: Cumulative exposures to 1,2-DCP ranged from 32 to 3433 ppm-years (mean, 851 ppm-years) and the SIR was 1171 (95% CI 682 to 1875). In the analysis of the four exposure categories, SIRs increased significantly in the three highest exposure categories, but not in the lowest category. Adjusted RRs in the middle and high exposure categories were 14.9 (95% CI 4.1 to 54.3) and 17.1 (95% CI 3.8 to 76.2), respectively, in the analysis without lag time, and were 11.4 (95% CI 3.3 to 39.6) and 32.4 (95% CI 6.4 to 163.9), respectively, in the analysis with a 5-year lag. The trend analysis revealed a significant increase in RR in association with increasing cumulative exposure to 1,2-DCP. DCM exposure was not significantly associated with the development of cholangiocarcinoma.Conclusions: The present study demonstrated an exposure-response relationship between exposure to 1,2-DCP and the development of cholangiocarcinoma. [ABSTRACT FROM AUTHOR]

Published
2016
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31. Drinking Pattern and Risk of Chronic Kidney Disease: The Kansai Healthcare Study.

Author

Sato, Kyoko Kogawa, Hayashi, Tomoshige, Uehara, Shinichiro, Kinuhata, Shigeki, Oue, Keiko, Endo, Ginji, Kambe, Hiroshi, and Fukuda, Kanji

Abstract

Background/Aims: The association between alcohol consumption and the risk of chronic kidney disease (CKD) has been reported. What is not known is whether drinking pattern combined with the weekly frequency of alcohol consumption and the quantity per drinking day is associated with the risk of CKD. Methods: We enrolled 9,112 Japanese nondiabetic men aged 40 to 55 years with absence of proteinuria, an estimated glomerular filtration rate (eGFR) of 60 ml/min/1.73 m2 or higher, and not on antihypertensive medications at baseline. CKD was defined if eGFR was <60 ml/min/1.73 m2. The weekly frequency classification was nondrinkers, 1-3 drinking days/week, or 4-7 drinking days/week. The quantity consumed per drinking day was classified as 0.1-23.0 g ethanol/drinking day, 23.1-46.0 g ethanol/drinking day, 46.1-69.0 g ethanol/drinking day, and ≥69.1 g ethanol/drinking day. Results: During the 79,099 person-years, 1,253 subjects developed CKD. Compared to nondrinkers, those who consumed 23.1-46.0 or 46.1-69.0 g ethanol/drinking day on 4-7 drinking days/week had a decreased risk of CKD (multiple-adjusted hazard ratio (HR) 0.62 (0.52-0.74) and 0.76 (0.59-0.97), respectively). The association between the quantity per drinking day and the incidence of CKD was U-shaped among each category of the weekly frequency. HRs within similar categories of quantity per drinking day were lower in the 4-7 drinking days/week group than in the 1-3 drinking days/week group. Conclusion: Among middle-aged Japanese men, the people who drank middle-range quantity, specifically who drank 4-7 days/week, had lower risk of CKD than nondrinkers. © 2014 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2015
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32. Occupational Exposure Limits for ethylidene norbornene, ethyleneimine, benomyl, and 2,3‐epoxypropyl methacrylate, and classifications on carcinogenicity

Author

Araki, Atsuko, Azuma, Kenichi, Endo, Ginji, Endo, Yoko, Fukushima, Tetsuhito, Hara, Kunio, Hori, Hajime, Horie, Seichi, Horiguchi, Hyogo, Ichiba, Masayoshi, Ichihara, Gaku, Ikeda, Masayuki, Ishitake, Tatsuya, Ito, Akiyoshi, Ito, Yuki, Iwasawa, Satoko, Kakumu, Takeyasu, Kamijima, Michihiro, Karita, Kanae, Katoh, Takahiko, Kawai, Toshio, Kawamoto, Toshihiro, Kumagai, Shinji, Kusaka, Yukinori, Matsumoto, Akiko, Miyagawa, Muneyuki, Miyauchi, Hiroyuki, Morimoto, Yasuo, Nagano, Kasuke, Naito, Hisao, Nakajima, Tamie, Nakano, Makiko, Nomiyama, Tetsuo, Okuda, Hirokazu, Okuda, Masayuki, Omae, Kazuyuki, Sakurai, Haruhiko, Sato, Kazuhiro, Sobue, Tomotaka, Suwazono, Yasushi, Takebayashi, Toru, Takeshita, Tatsuya, Takeuchi, Akito, Takeuchi, Ayano, Tanaka, Masatoshi, Tanaka, Shigeru, Tsukahara, Teruomi, Tsunoda, Masashi, Ueno, Susumu, Ueyama, Jun, Umeda, Yumi, Yamamoto, Kenya, Yamano, Yuko, Yamauchi, Takenori, and Yano, Eiji

Published
2018
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33. Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant

Author

Azuma, Kenichi, Endo, Ginji, Endo, Yoko, Fukushima, Tetsuhito, Hara, Kunio, Hori, Hajime, Horie, Seichi, Horiguchi, Hyogo, Ichiba, Masayoshi, Ichihara, Gaku, Ikeda, Masayuki, Ishitake, Tatsuya, Ito, Akiyoshi, Ito, Yuki, Iwasawa, Satoko, Kamijima, Michihiro, Karita, Kanae, Katoh, Takahiko, Kawai, Toshio, Kawamoto, Toshihiro, Kishi, Reiko, Kumagai, Shinji, Kusaka, Yukinori, Matsumoto, Akiko, Miyagawa, Muneyuki, Miyauchi, Hiroyuki, Morimoto, Yasuo, Nagano, Kasuke, Naito, Hisao, Nakajima, Tamie, Nomiyama, Tetsuo, Okuda, Hirokazu, Omae, Kazuyuki, Sakurai, Haruhiko, Sato, Kazuhiro, Sobue, Tomotaka, Suwazono, Yasushi, Takebayashi, Toru, Takeshita, Tatsuya, Takeuchi, Akito, Takeuchi, Ayano, Tanaka, Masatoshi, Tanaka, Shigeru, Tsukahara, Teruomi, Tsunoda, Masashi, Ueno, Susumu, Ueyama, Jun, Umeda, Yumi, Yamano, Yuko, Yamauchi, Takenori, and Yano, Eiji

Published
2017
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34. Occupational Exposure Limits of lead, dimethylamine, n‐butyl‐2,3 epoxypropyl ether, and 2‐ethyl‐1‐hexanol and carcinogenicity and occupational sensitizer classification

Author

Azuma, Kenichi, Endo, Ginji, Endo, Yoko, Hara, Kunio, Harada, Koji, Hori, Hajime, Horie, Seichi, Horiguchi, Hyogo, Ichiba, Masayoshi, Ichihara, Gaku, Ikeda, Masayuki, Ishitake, Tatsuya, Ito, Akiyoshi, Iwasawa, Satoko, Kamijima, Michihiro, Karita, Kanae, Kawai, Toshio, Kawamoto, Toshihiro, Koizumi, Akio, Kumagai, Shinji, Kusaka, Yukinori, Miyagawa, Muneyuki, Morimoto, Yasuo, Nagano, Kasuke, Nasu, Tamie, Nomiyama, Tetsuo, Omae, Kazuyuki, Sato, Kazuhiro, Okuda, Hirokazu, Sakurai, Haruhiko, Sobue, Tomotaka, Suwazono, Yasushi, Takebayashi, Toru, Takeshita, Tatsuya, Takeuchi, Akito, Tanaka, Masatoshi, Tanaka, Shigeru, Tsukahara, Teruomi, Tsunoda, Masashi, Ueno, Susumu, Yamano, Yuko, Yamauchi, Takenori, and Yano, Eiji

Published
2016
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35. Occupational exposure limits for acetaldehyde, 2‐bromopropane, glyphosate, manganese and inorganic manganese compounds, and zinc oxide nanoparticle, and the biological exposure indices for cadmium and cadmium compounds and ethylbenzene, and carcinogenicity, occupational sensitizer, and reproductive toxicant classifications

Author

Araki, Atsuko, Azuma, Kenichi, Endo, Ginji, Endo, Yoko, Fukushima, Tetsuhito, Hara, Kunio, Harada, Kouji, Hori, Hajime, Horie, Seichi, Horiguchi, Hyogo, Ichiba, Masayoshi, Ichihara, Gaku, Ishitake, Tatsuya, Ito, Akiyoshi, Ito, Yuki, Iwasawa, Satoko, Kakamu, Takeyasu, Kamijima, Michihiro, Karita, Kanae, Kawai, Toshio, Kawamoto, Toshihiro, Kishi, Reiko, Kumagai, Shinji, Matsumoto, Akiko, Miyagawa, Muneyuki, Miyauchi, Hiroyuki, Morimoto, Yasuo, Nagano, Kasuke, Naito, Hisao, Nakajima, Tamie, Nakano, Makiko, Nomiyama, Tetsuo, Okuda, Hirokazu, Okuda, Masayuki, Omae, Kazuyuki, Sato, Kazuhiro, Sobue, Tomotaka, Suwazono, Yasushi, Takebayashi, Toru, Takeshita, Tatsuya, Takeuchi, Akito, Takeuchi, Ayano, Tanaka, Shigeru, Tsuji, Mayumi, Tsukahara, Teruomi, Ueno, Susumu, Ueyama, Jun, Umeda, Yumi, Yamamoto, Kenya, Yamano, Yuko, Yamauchi, Takenori, and Yano, Eiji

Published
2021
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