1. Brain accumulation of inhaled uranium in the rat depends on aerosol concentration, exposure repetitions, particle size and solubility
- Author
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Benjamin B. Tournier, Philippe Lestaevel, F. Petitot, Chrystelle Ibanez, Isabelle Dublineau, François Paquet, Elie Tourlonias, Division of Adult Psychiatry, Department of Psychiatry, University Hospitals of Geneva, PSE-SANTE/SESANE/LRTOX, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Nucléagis SAS, CEA, (DEN, DUSP, Service de Protection contre les Rayonnements), PSE-ENV/SEREN, PSE-ENV/SEDRE/USDR, PSE-SANTE/SER/BASEP, Hôpital Universitaire de Genève = University Hospitals of Geneva (HUG), Laboratoire de radiotoxicologie et radiobiologie expérimentale (IRSN/PSE-SANTE/SESANE/LRTOX), Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants (IRSN/PSE-SANTE/SESANE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Service d'expertise et d'étude en radioprotection des populations et de la radioactivité dans l'environnement (IRSN/PSE-ENV/SEREN), Unité d'expertise des sites et des déchets radioactifs (IRSN/PSE-ENV/SEDRE/USDR), Service des déchets radioactifs et des transferts dans la géosphère (IRSN/PSE-ENV/SEDRE), Bureau d'analyse et de suivi des expositions professionnelles (IRSN/PSE-SANTE/SER/BASEP), and Service d'études et d'expertise en radioprotection (IRSN/PSE-SANTE/SER)
- Subjects
Male ,[SDV]Life Sciences [q-bio] ,chemistry.chemical_element ,Toxicology ,Rats, Sprague-Dawley ,03 medical and health sciences ,Random Allocation ,ddc:616.89 ,0302 clinical medicine ,Dose effect ,Animals ,Solubility ,Particle Size ,Administration, Intranasal ,030304 developmental biology ,Aerosols ,0303 health sciences ,Inhalation ,Radiochemistry ,Low dose ,Brain ,General Medicine ,Uranium ,Uranium Compounds ,Aerosol ,Rats ,chemistry ,Acute exposure ,Nanoparticles ,Rat ,Particle size ,030217 neurology & neurosurgery - Abstract
A rostro-caudal gradient of uranium (U) in the brain has been suggested after its inhalation. To study the factors influencing this mapping, we first used 30-min acute inhalation at 56 mg/m3of the relatively soluble form UO4in the rat. These exposure parameters were then used as a reference in comparison with the other experimental conditions. Other groups received acute inhalation at different concentrations, repeated low dose inhalation of UO4(10 exposures) or acute low dose inhalation of the insoluble form UO2. At 24 h after the last exposure, all rats showed a brain U accumulation with a rostro-caudal gradient as compared to controls. However, the total concentration to the brain was greater after repeated exposure than acute exposure, demonstrating an accumulative effect. In comparison with the low dose soluble U exposure, a higher accumulation in the front of the brain was observed after exposure to higher dose, to insoluble particles and following repetition of exposures, thus demonstrating a dose effect and influences of solubility and repetition of exposures. In the last part, exposure to ultrafine U particles made it possible to show 24 h after exposure the presence of U in the brain according to a rostro-caudal gradient. Finally, the time-course after exposure to micronic or nanometric U particles has revealed greater residence times for nanoparticles.
- Published
- 2021
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