1. Analysis of prognostic factors in Grade 3 endometrioid type endometrial carcinoma
- Author
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Eda Adeviye Sahin, Serhat Toprak, Hasan Berkan Sayal, Tekin Ekinci, Ercan Yılmaz, Kadir Bakay, Rauf Melekoğlu, Burak Sezgin, Yusuf Aytaç Tohma, and Hanifi Şahin
- Subjects
Child, Preschool ,Humans ,Obstetrics and Gynecology ,Female ,General Medicine ,Neoplasm Recurrence, Local ,Child ,Prognosis ,Carcinoma, Endometrioid ,Retrospective Studies ,Endometrial Neoplasms ,Neoplasm Staging - Abstract
To investigate the prognostic factors of patients with Grade 3 endometrioid endometrial cancer (G3EEC).This four-center, retrospective study included a total of 129 women with G3EEC. Demographic, clinicopathologic, and survival data were collected. Kaplan-Meier method was used for survival analysis. Predictors of outcome were analyzed using Cox proportional hazards models.Median age at the time of diagnosis was 63 (range 39-87) years and median follow up was 37 (range 6-126) months. For the entire cohort, the 5-year disease-free survival (DFS) and overall survival (OS) were 54.3% and 63.6%, respectively. The 5-year DFS rates for lymphovascular space invasion (LVSI) -positive and -negative patients were 41.6% and 88.3%, respectively (P 0.001). The 5-year OS rates for LVSI-positive and -negative patients were 54.7% and 88.3%, respectively (P = 0.001). Positive LVSI status was identified as the independent prognostic factor for decreased DFS and OS (hazard ratio [HR] 5.5, 95% confidence interval [CI] 1.65-18.86; P = 0.006 versus HR 4.4, 95% CI 1.33-14.58; P = 0.013, respectively).LVSI seems to be an independent prognostic factor for decreased DFS and OS in G3EEC patients.
- Published
- 2022
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