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1. Impact of social determinants of health on the outcomes of Latin American children with Multisystem Inflammatory Syndrome (MIS-C).

Author

Buonsenso, Danilo, Camporesi, Anna, Sawaya, Charles, Ulloa-Gutierrez, Rolando, Faugier-Fuentes, Enrique, Dueñas, Lourdes, Paternina-de la Ossa, Rolando, Llamas-Guillén, Beatriz, Gámez-González, Luisa, Gálvez-Rafael, Nancy, Gatica, Andrea, Saltigeral-Simental, Patricia, Cuatecontzi-Romero, Adán, Almeida, Flávia, Cuan, Shirley, Zapata-Yarlequé, Elmer, Beltrán, Sandra, Reina-Bautista, Erika, Collia, Adrián, Ivankovich-Escoto, Gabriela, Fernández-Sarmiento, Jaime, and Tremoulet, Adriana

Subjects
Latin America, children, multisystem inflammatory syndrome, risk factors, social determinants of health
Abstract

IMPORTANCE: There is growing understanding that Social Determinants of Health (SDH) impact on the outcomes of different pediatric conditions. We aimed to determine whether SDH affect the severity of MIS-C. DESIGN: Retrospective cohort study, 2021-2023. Children and adolescents with MIS-C younger than 18 years of age fulfilling the MIS-C CDC definition within the REKAMLATINA network were invited to participate. We assessed the impact of SDH on the risk of children with MIS-C to be diagnosed with shock, need of inotropes, respiratory support, transfusion, and death. RESULTS: Two hundred and seventy seven patients from 30 centers in 13 countries were included. Of them, 241 children from the four most-represented countries were included in the final analysis. Food insecurity, higher distance from a health center, not possessing a private vehicle to transport the patient to hospital, and having a home in poor condition, were associated with low LVEF, need of transfusion, shock, and need for respiratory support, when controlling for age, BMI, and ethnicity. The Score of Social Disadvantage was associated with Shock (OR: 1.35, P: 0.011, 95% CI: 1.07-1.71), Respiratory support (OR: 1.39, P: 0.005, 95% CI: 1.1-1.75), Transfusion (OR: 1.63, P0.013, 95% CI 1.1-2.41), but not death (OR: 0.76, P: 0.38, 95% CI: 0.41-1.40). CONCLUSIONS: Among a large cohort of Latin American children with MIS-C, SDH negatively affect outcomes. These findings reinforce the need for better investigation of the role of SDH in MIS-C and other inflammatory conditions and may guide public health interventions.

Published
2024

2. Prospective cohort study of incidence and risk factors for catheter-associated urinary tract infections in 145 intensive care units of 9 Latin American countries: INICC findings

Author

Yin, Ruijie, Jin, Zhilin, Lee, Brandon Hochahn, Alvarez, Gustavo Andres, Stagnaro, Juan Pablo, Valderrama-Beltran, Sandra Liliana, Gualtero, Sandra Milena, Jiménez-Alvarez, Luisa Fernanda, Reyes, Lidia Patricia, Henao Rodas, Claudia Milena, Gomez, Katherine, Alarcon, Johana, Aguilar Moreno, Lina Alejandra, Bravo Ojeda, Juan Sebastian, Cano Medina, Yuliana Andrea, Chapeta Parada, Edwin Giovannny, Zuniga Chavarria, Maria Adelia, Quesada Mora, Ana Marcela, Aguirre-Avalos, Guadalupe, Mijangos-Méndez, Julio Cesar, Sassoe-Gonzalez, Alejandro, Millán-Castillo, Claudia Marisol, Aleman-Bocanegra, Mary Cruz, Echazarreta-Martínez, Clara Veronica, Hernandez-Chena, Blanca Estela, Jarad, Rajab Mohamed Abu, Villegas-Mota, Maria Isabel, Montoya-Malváez, Mildred, Aguilar-de-Moros, Daisy, Castaño-Guerra, Elizabeth, Córdoba, Judith, Castañeda-Sabogal, Alex, Medeiros, Eduardo Alexandrino, Fram, Dayana, Dueñas, Lourdes, Carreazo, Nilton Yhuri, Salgado, Estuardo, and Rosenthal, Victor Daniel

Published
2023
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3. Examining the impact of a 9-component bundle and the INICC multidimensional approach on catheter-associated urinary tract infection rates in 32 countries across Asia, Eastern Europe, Latin America, and the Middle East

Author

Rosenthal, Victor D., Yin, Ruijie, Jin, Zhilin, Perez, Valentina, Kis, Matthew A., Abdulaziz-Alkhawaja, Safaa, Valderrama-Beltran, Sandra L., Gomez, Katherine, Rodas, Claudia M.H., El-Sisi, Amal, Sahu, Suneeta, Kharbanda, Mohit, Rodrigues, Camilla, Myatra, Sheila N., Chawla, Rajesh, Sandhu, Kavita, Mehta, Yatin, Rajhans, Prasad, Arjun, Rajalakshmi, Tai, Chian-Wern, Bhakta, Arpita, Mat Nor, Mohd-Basri, Aguirre-Avalos, Guadalupe, Sassoe-Gonzalez, Alejandro, Bat-Erdene, Ider, Acharya, Subhash P., Aguilar-de-Moros, Daisy, Carreazo, Nilton Yhuri, Duszynska, Wieslawa, Hlinkova, Sona, Yildizdas, Dincer, Kılıc, Esra K., Dursun, Oguz, Odek, Caglar, Deniz, Suna S.O., Guclu, Ertugrul, Koksal, Iftihar, Medeiros, Eduardo A., Petrov, Michael M., Tao, Lili, Salgado, Estuardo, Dueñas, Lourdes, Daboor, Mohammad A., Raka, Lul, Omar, Abeer A., Ikram, Aamer, Horhat-Florin, George, Memish, Ziad A., and Brown, Eric C.

Published
2024
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4. Assessing the impact of a multidimensional approach and an 8-component bundle in reducing incidences of ventilator-associated pneumonia across 35 countries in Latin America, Asia, the Middle East, and Eastern Europe

Author

Rosenthal, Victor Daniel, Jin, Zhilin, Yin, Ruijie, Sahu, Suneeta, Rajhans, Prasad, Kharbanda, Mohit, Nair, Pravin K., Mishra, Shakti Bedanta, Chawla, Rajesh, Arjun, Rajalakshmi, Sandhu, Kavita, Rodrigues, Camilla, Dongol, Reshma, Myatra, Sheila Nainan, Mohd-Basri, Mat Nor, Chian-Wern, Tai, Bhakta, Arpita, Bat-Erdene, Ider, Acharya, Subhash P., Alvarez, Gustavo Andres, Moreno, Lina Alejandra Aguilar, Gomez, Katherine, da Jimenez-Alvarez, Luisa Fernanda, Henao-Rodas, Claudia Milena, Valderrama-Beltran, Sandra Liliana, Zuniga-Chavarria, Maria Adelia, Aguirre-Avalos, Guadalupe, Hernandez-Chena, Blanca Estela, Sassoe-Gonzalez, Alejandro, Aleman-Bocanegra, Mary Cruz, Villegas-Mota, Maria Isabel, De Moros, Daisy Aguilar, Castaneda-Sabogal, Alex, Carreazo, Nilton Yhuri, Alkhawaja, Safaa, Agha, Hala Mounir, El-Kholy, Amani, Abdellatif-Daboor, Mohammad, Dursun, Oguz, Okulu, Emel, Havan, Merve, Yildizdas, Dincer, Deniz, Suna Secil Ozturk, Guclu, Ertugrul, Hlinkova, Sona, Ikram, Aamer, Tao, Lili, Omar, Abeer Aly, Elahi, Naheed, Memish, Ziad A., Petrov, Michael M., Raka, Lul, Janc, Jarosław, Horhat-Florin, George, Medeiros, Eduardo Alexandrino, Salgado, Estuardo, Dueñas, Lourdes, Coloma, Monica, Perez, Valentina, and Brown, Eric Christopher

Published
2024
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5. Clinical Presentation and Outcomes of Kawasaki Disease in Children from Latin America: A Multicenter Observational Study from the REKAMLATINA Network

Author

Gámez-González, Luisa B., Pérez-Camacho, Paola, Patiño, Jaime, Cleves, Daniela, Franco, Lorena, Avila-Agüero, Maria L., Camacho-Badilla, Kattia, Soriano-Fallas, Alejandra, Li-Chan, Susan, Valverde, Kathia, Collia, Adrián, Ellis, Alejandro, Grazioso, Carlos F., Grazioso, Pablo J., Calvimontes, Gonzalo, Izquierdo, Giannina, Picart, Pilar, Melgar, Mario, Salgado, Andrea, Borzutzky, Arturo, Arbo, Antonio, Lovera, Dolores, Amarilla, Sara, Galeano, Fernando, Astigarraga, Norma, Luis-Álvarez, Maria del Carmen, Fynn, Estefanía, Assandri, Elizabeth, Levy, Jacqueline, Castaño, Elizabeth, Esquivel, Raúl, Norero, Ximena, Sinisterra, Scarlet, Daza, Carlos, Record, Javier, Hurtado-Palacios, Isabel C., Madrid, Antonio, Calvache-Burbano, Angélica, Fernández, Antonio, Sánchez, Yasmín, Freire, Dolores, Yamazaki-Nakashimada, Marco A., Rodríguez-Herrera, Raymundo, López-Gallegos, Diana, Márquez-González, Horacio, Díaz-Maldonado, Adriana, Marquez-Herrera, Kelly, Sakita, Neusa Keico, Badue Pereira, María Fernanda, Leal, Gabriela Nunes, Guarnizo, Pilar, Huertas-Quiñones, Manuel, López, Pio, Deseda-Tous, Jaime, Pujadas, Mónica, Soza, Guillermo, Cerda, Carolina, López-Medina, Issa Lorena, Hernández-Magaña, Rafael, Passos, Saulo Duarte, Rubio-Pérez, Nadina, García-Rodríguez, Fernando, Martínez-Ramírez, Rogelio, Rodríguez-Muñoz, Lorena, Flores-Hernández, Karina, Díaz-Díaz, Alejandro, Mesa-Monsalve, Juan G., Somarriba, María Mercedes, de Lara-Huerta, Jesús, Narayan, Hari K., Lizcano, Anel, Lam-Hine, Tracy, Ulloa-Gutierrez, Rolando, Bainto, Emelia V., Garrido-García, Luis M., Estripeaut, Dora, del Aguila, Olguita, Gómez, Virgen, Faugier-Fuentes, Enrique, Miño-León, Greta, Beltrán, Sandra, Cofré, Fernanda, Chacon-Cruz, Enrique, Saltigeral-Simental, Patricia, Martínez-Medina, Lucila, Dueñas, Lourdes, Luciani, Kathia, Rodríguez-Quiroz, Francisco J., Camacho Moreno, Germán, Viviani, Tamara, Alvarez-Olmos, Martha I., Marques, Heloisa Helena de Sousa, López-Medina, Eduardo, Pirez, María C., and Tremoulet, Adriana H.

Published
2023
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6. Multinational prospective cohort study of incidence and risk factors for central line-associated bloodstream infections in ICUs of 8 Latin American countries

Author

Rosenthal, Victor Daniel, Jin, Zhilin, Valderrama-Beltran, Sandra Liliana, Gualtero, Sandra Milena, Linares, Claudia Yaneth, Aguirre-Avalos, Guadalupe, Mijangos-Méndez, Julio Cesar, Ibarra-Estrada, Miguel Ángel, Jiménez-Alvarez, Luisa Fernanda, Reyes, Lidia Patricia, Alvarez-Moreno, Carlos Arturo, Zuniga-Chavarria, Maria Adelia, Quesada-Mora, Ana Marcela, Gomez, Katherine, Alarcon, Johana, Millan-Oñate, Jose, Aguilar-de-Moros, Daisy, Castaño-Guerrero, Elizabeth, Córdoba, Judith, Sassoe-Gonzalez, Alejandro, Millán-Castillo, Claudia Marisol, Leyva-Xotlanihua, Lissette, Aguilar-Moreno, Lina Alejandra, Bravo-Ojeda, Juan Sebastian, Gutierrez-Tobar, Ivan Felipe, Aleman-Bocanegra, Mary Cruz, Echazarreta-Martínez, Clara Veronica, Flores-Sánchez, Belinda Mireya, Cano-Medina, Yuliana Andrea, Chapeta-Parada, Edwin Giovannny, Gonzalez-Niño, Rafael Antonio, Villegas-Mota, Maria Isabel, Montoya-Malváez, Mildred, Cortés-Vázquez, Miguel Ángel, Medeiros, Eduardo Alexandrino, Fram, Dayana, Vieira-Escudero, Daniela, Dueñas, Lourdes, Carreazo, Nilton Yhuri, Salgado, Estuardo, and Yin, Ruijie

Published
2023
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7. Presentation and Outcomes of Kawasaki Disease in Latin American Infants Younger Than 6 Months of Age: A Multinational Multicenter Study of the REKAMLATINA Network

Author

Moreno, Elizabeth, Garcia, S Diana, Bainto, Emelia, Salgado, Andrea P, Parish, Austin, Rosellini, Benjamin D, Ulloa-Gutierrez, Rolando, Garrido-Garcia, Luis M, Dueñas, Lourdes, Estripeaut, Dora, Luciani, Kathia, Rodríguez-Quiroz, Francisco J, del Aguila, Olguita, Camacho-Moreno, Germán, Gómez, Virgen, Viviani, Tamara, Alvarez-Olmos, Martha I, de Souza Marques, Heloisa Helena, Faugier-Fuentes, Enrique, Saltigeral-Simental, Patricia, López-Medina, Eduardo, Miño-León, Greta, Beltrán, Sandra, Martínez-Medina, Lucila, Pirez, Maria C, Cofré, Fernanda, and Tremoulet, Adriana H

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, Brain Disorders, Clinical Trials and Supportive Activities, Clinical Research, Kawasaki disease, Latin America, infants, coronary artery abnormalities, delayed diagnosis, The REKAMLATINA-2 Study Group Investigators, Paediatrics and Reproductive Medicine, Other Medical and Health Sciences, Paediatrics
Abstract

Objective: To characterize the clinical presentation and outcomes of Kawasaki disease (KD) in infants 10 days (50 vs. 7.4%, P = 0.043)]. Conclusion: Our data show that despite treatment in the first 10 days of illness, infants

Published
2020

8. Use of Adjunctive Therapy in Acute Kawasaki Disease in Latin America

Author

Fortuna-Reyna, Brenda, Bainto, Emelia V, Ulloa-Gutierrez, Rolando, Garrido-García, Luis M, Estripeaut, Dora, del Águila, Olguita, Gómez, Virgen, Faugier-Fuentes, Enrique, Miño-León, Greta, Beltrán, Sandra, Cofré, Fernanda, Chacón-Cruz, Enrique, Saltigeral-Simental, Patricia, Martínez-Medina, Lucila, Dueñas, Lourdes, Luciani, Kathia, Rodríguez-Quiroz, Francisco J, Camacho-Moreno, German, Viviani, Tamara, Alvarez-Olmos, Martha I, de Sousa Marques, Heloisa Helena, López-Medina, Eduardo, Pirez, María C, Tremoulet, Adriana H, and Group, The Kawasaki Disease REKAMLATINA Network Study

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Rare Diseases, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Kawasaki disease, Latin America, steroids, infliximab, adjunctive therapy, Kawasaki Disease REKAMLATINA Network Study Group, Paediatrics and Reproductive Medicine, Other Medical and Health Sciences, Paediatrics
Abstract

Objective: To characterize the use of adjunctive therapy in Kawasaki disease (KD) in Latin America. Methods: The study included 1,418 patients from the Latin American KD Network (REKAMLATINA) treated for KD between January 1, 2009, and May 31, 2017. Results: Of these patients, 1,152 received only a single dose of IVIG, and 266 received additional treatment. Age at onset was similar in both groups (median 2 vs. 2.2 years, respectively). The majority of patients were male (58 vs. 63.9%) and were hospitalized with the first 10 days of fever (85.1 vs. 84.2%). The most common adjunctive therapy administered was steroids for IVIG-resistance, followed by additional doses of IVIG. The use of biologics such as infliximab was limited. KD patients who received adjunctive therapy were more likely to have a lower platelet count and albumin level as well as a higher Z score of the coronary arteries. Conclusion: This is the first report of adjunctive therapies for KD across Latin America. IVIG continues to be the initial and resistance treatment, however, steroids are also used and to a lesser extent, biological therapy such as infliximab. Future studies should address the barriers to therapy in children with acute KD throughout Latin America.

Published
2020

9. Incidence and risk factors for catheter-associated urinary tract infection in 623 intensive care units throughout 37 Asian, African, Eastern European, Latin American, and Middle Eastern nations: A multinational prospective research of INICC

Author

Rosenthal, Victor Daniel, Yin, Ruijie, Brown, Eric Christopher, Lee, Brandon Hochahn, Rodrigues, Camilla, Myatra, Sheila Nainan, Kharbanda, Mohit, Rajhans, Prasad, Mehta, Yatin, Todi, Subhash Kumar, Basu, Sushmita, Sahu, Suneeta, Mishra, Shakti Bedanta, Chawla, Rajesh, Nair, Pravin K., Arjun, Rajalakshmi, Singla, Deepak, Sandhu, Kavita, Palaniswamy, Vijayanand, Bhakta, Arpita, Nor, Mohd Basri Mat, Chian-Wern, Tai, Bat-Erdene, Ider, Acharya, Subhash P., Ikram, Aamer, Tumu, Nellie, Tao, Lili, Alvarez, Gustavo Andres, Valderrama-Beltran, Sandra Liliana, Jiménez-Alvarez, Luisa Fernanda, Henao-Rodas, Claudia Milena, Gomez, Katherine, Aguilar-Moreno, Lina Alejandra, Cano-Medina, Yuliana Andrea, Zuniga-Chavarria, Maria Adelia, Aguirre-Avalos, Guadalupe, Sassoe-Gonzalez, Alejandro, Aleman-Bocanegra, Mary Cruz, Hernandez-Chena, Blanca Estela, Villegas-Mota, Maria Isabel, Aguilar-De-Moros, Daisy, Castañeda-Sabogal, Alex, Medeiros, Eduardo Alexandrino, Dueñas, Lourdes, Carreazo, Nilton Yhuri, Salgado, Estuardo, Abdulaziz-Alkhawaja, Safaa, Agha, Hala Mounir, El-Kholy, Amani Ali, Daboor, Mohammad Abdellatif, Guclu, Ertugrul, Dursun, Oguz, Koksal, Iftihar, Havan, Merve, Ozturk-Deniz, Suna Secil, Yildizdas, Dincer, Okulu, Emel, Omar, Abeer Aly, Memish, Ziad A., Janc, Jarosław, Hlinkova, Sona, Duszynska, Wieslawa, Horhat-Florin, George, Raka, Lul, Petrov, Michael M., Jin, Zhilin, Rosenthal, Victor Daniel, Yin, Ruijie, Brown, Eric Christopher, Lee, Brandon Hochahn, Rodrigues, Camilla, Myatra, Sheila Nainan, Kharbanda, Mohit, Rajhans, Prasad, Mehta, Yatin, Todi, Subhash Kumar, Basu, Sushmita, Sahu, Suneeta, Mishra, Shakti Bedanta, Chawla, Rajesh, Nair, Pravin K., Arjun, Rajalakshmi, Singla, Deepak, Sandhu, Kavita, Palaniswamy, Vijayanand, Bhakta, Arpita, Nor, Mohd Basri Mat, Chian-Wern, Tai, Bat-Erdene, Ider, Acharya, Subhash P., Ikram, Aamer, Tumu, Nellie, Tao, Lili, Alvarez, Gustavo Andres, Valderrama-Beltran, Sandra Liliana, Jiménez-Alvarez, Luisa Fernanda, Henao-Rodas, Claudia Milena, Gomez, Katherine, Aguilar-Moreno, Lina Alejandra, Cano-Medina, Yuliana Andrea, Zuniga-Chavarria, Maria Adelia, Aguirre-Avalos, Guadalupe, Sassoe-Gonzalez, Alejandro, Aleman-Bocanegra, Mary Cruz, Hernandez-Chena, Blanca Estela, Villegas-Mota, Maria Isabel, Aguilar-De-Moros, Daisy, Castañeda-Sabogal, Alex, Medeiros, Eduardo Alexandrino, Dueñas, Lourdes, Carreazo, Nilton Yhuri, Salgado, Estuardo, Abdulaziz-Alkhawaja, Safaa, Agha, Hala Mounir, El-Kholy, Amani Ali, Daboor, Mohammad Abdellatif, Guclu, Ertugrul, Dursun, Oguz, Koksal, Iftihar, Havan, Merve, Ozturk-Deniz, Suna Secil, Yildizdas, Dincer, Okulu, Emel, Omar, Abeer Aly, Memish, Ziad A., Janc, Jarosław, Hlinkova, Sona, Duszynska, Wieslawa, Horhat-Florin, George, Raka, Lul, Petrov, Michael M., and Jin, Zhilin

Abstract

Objective: To identify urinary catheter (UC)-associated urinary tract infection (CAUTI) incidence and risk factors. Design: A prospective cohort study. Setting: The study was conducted across 623 ICUs of 224 hospitals in 114 cities in 37 African, Asian, Eastern European, Latin American, and Middle Eastern countries. Participants: The study included 169,036 patients, hospitalized for 1,166,593 patient days. Methods: Data collection took place from January 1, 2014, to February 12, 2022. We identified CAUTI rates per 1,000 UC days and UC device utilization (DU) ratios stratified by country, by ICU type, by facility ownership type, by World Bank country classification by income level, and by UC type. To estimate CAUTI risk factors, we analyzed 11 variables using multiple logistic regression. Results: Participant patients acquired 2,010 CAUTIs. The pooled CAUTI rate was 2.83 per 1,000 UC days. The highest CAUTI rate was associated with the use of suprapubic catheters (3.93 CAUTIs per 1,000 UC days); with patients hospitalized in Eastern Europe (14.03) and in Asia (6.28); with patients hospitalized in trauma (7.97), neurologic (6.28), and neurosurgical ICUs (4.95); with patients hospitalized in lower-middle-income countries (3.05); and with patients in public hospitals (5.89). The following variables were independently associated with CAUTI: Age (adjusted odds ratio [aOR], 1.01; P <.0001), female sex (aOR, 1.39; P <.0001), length of stay (LOS) before CAUTI-acquisition (aOR, 1.05; P <.0001), UC DU ratio (aOR, 1.09; P <.0001), public facilities (aOR, 2.24; P <.0001), and neurologic ICUs (aOR, 11.49; P <.0001). Conclusions: CAUTI rates are higher in patients with suprapubic catheters, in middle-income countries, in public hospitals, in trauma and neurologic ICUs, and in Eastern European and Asian facilities. Based on findings regarding risk factors for CAUTI, focus on reducing LOS and UC utilization is warranted, as well as implementing evidence-based CAUTI-prevention recomm

Published
2024

10. Incidence and risk factors for catheter-associated urinary tract infection in 623 intensive care units throughout 37 Asian, African, Eastern European, Latin American, and Middle Eastern nations: A multinational prospective research of INICC

Author

Rosenthal, Victor Daniel, primary, Yin, Ruijie, additional, Brown, Eric Christopher, additional, Lee, Brandon Hochahn, additional, Rodrigues, Camilla, additional, Myatra, Sheila Nainan, additional, Kharbanda, Mohit, additional, Rajhans, Prasad, additional, Mehta, Yatin, additional, Todi, Subhash Kumar, additional, Basu, Sushmita, additional, Sahu, Suneeta, additional, Mishra, Shakti Bedanta, additional, Chawla, Rajesh, additional, Nair, Pravin K., additional, Arjun, Rajalakshmi, additional, Singla, Deepak, additional, Sandhu, Kavita, additional, Palaniswamy, Vijayanand, additional, Bhakta, Arpita, additional, Nor, Mohd-Basri Mat, additional, Chian-Wern, Tai, additional, Bat-Erdene, Ider, additional, Acharya, Subhash P., additional, Ikram, Aamer, additional, Tumu, Nellie, additional, Tao, Lili, additional, Alvarez, Gustavo Andres, additional, Valderrama-Beltran, Sandra Liliana, additional, Jiménez-Alvarez, Luisa Fernanda, additional, Henao-Rodas, Claudia Milena, additional, Gomez, Katherine, additional, Aguilar-Moreno, Lina Alejandra, additional, Cano-Medina, Yuliana Andrea, additional, Zuniga-Chavarria, Maria Adelia, additional, Aguirre-Avalos, Guadalupe, additional, Sassoe-Gonzalez, Alejandro, additional, Aleman-Bocanegra, Mary Cruz, additional, Hernandez-Chena, Blanca Estela, additional, Villegas-Mota, Maria Isabel, additional, Aguilar-de-Moros, Daisy, additional, Castañeda-Sabogal, Alex, additional, Medeiros, Eduardo Alexandrino, additional, Dueñas, Lourdes, additional, Carreazo, Nilton Yhuri, additional, Salgado, Estuardo, additional, Abdulaziz-Alkhawaja, Safaa, additional, Agha, Hala Mounir, additional, El-Kholy, Amani Ali, additional, Daboor, Mohammad Abdellatif, additional, Guclu, Ertugrul, additional, Dursun, Oguz, additional, Koksal, Iftihar, additional, Havan, Merve, additional, Ozturk-Deniz, Suna Secil, additional, Yildizdas, Dincer, additional, Okulu, Emel, additional, Omar, Abeer Aly, additional, Memish, Ziad A., additional, Janc, Jarosław, additional, Hlinkova, Sona, additional, Duszynska, Wieslawa, additional, Horhat-Florin, George, additional, Raka, Lul, additional, Petrov, Michael M., additional, and Jin, Zhilin, additional

Published
2024
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11. Clinical Presentation and Outcomes of Kawasaki Disease in Children from Latin America: A Multicenter Observational Study from the REKAMLATINA Network

Author

Narayan, Hari K., primary, Lizcano, Anel, additional, Lam-Hine, Tracy, additional, Ulloa-Gutierrez, Rolando, additional, Bainto, Emelia V., additional, Garrido-García, Luis M., additional, Estripeaut, Dora, additional, del Aguila, Olguita, additional, Gómez, Virgen, additional, Faugier-Fuentes, Enrique, additional, Miño-León, Greta, additional, Beltrán, Sandra, additional, Cofré, Fernanda, additional, Chacon-Cruz, Enrique, additional, Saltigeral-Simental, Patricia, additional, Martínez-Medina, Lucila, additional, Dueñas, Lourdes, additional, Luciani, Kathia, additional, Rodríguez-Quiroz, Francisco J., additional, Camacho Moreno, Germán, additional, Viviani, Tamara, additional, Alvarez-Olmos, Martha I., additional, Marques, Heloisa Helena de Sousa, additional, López-Medina, Eduardo, additional, Pirez, María C., additional, Tremoulet, Adriana H., additional, Gámez-González, Luisa B., additional, Pérez-Camacho, Paola, additional, Patiño, Jaime, additional, Cleves, Daniela, additional, Franco, Lorena, additional, Avila-Agüero, Maria L., additional, Camacho-Badilla, Kattia, additional, Soriano-Fallas, Alejandra, additional, Li-Chan, Susan, additional, Valverde, Kathia, additional, Collia, Adrián, additional, Ellis, Alejandro, additional, Grazioso, Carlos F., additional, Grazioso, Pablo J., additional, Calvimontes, Gonzalo, additional, Izquierdo, Giannina, additional, Picart, Pilar, additional, Melgar, Mario, additional, Salgado, Andrea, additional, Borzutzky, Arturo, additional, Arbo, Antonio, additional, Lovera, Dolores, additional, Amarilla, Sara, additional, Galeano, Fernando, additional, Astigarraga, Norma, additional, Luis-Álvarez, Maria del Carmen, additional, Fynn, Estefanía, additional, Assandri, Elizabeth, additional, Levy, Jacqueline, additional, Castaño, Elizabeth, additional, Esquivel, Raúl, additional, Norero, Ximena, additional, Sinisterra, Scarlet, additional, Daza, Carlos, additional, Record, Javier, additional, Hurtado-Palacios, Isabel C., additional, Madrid, Antonio, additional, Calvache-Burbano, Angélica, additional, Fernández, Antonio, additional, Sánchez, Yasmín, additional, Freire, Dolores, additional, Yamazaki-Nakashimada, Marco A., additional, Rodríguez-Herrera, Raymundo, additional, López-Gallegos, Diana, additional, Márquez-González, Horacio, additional, Díaz-Maldonado, Adriana, additional, Marquez-Herrera, Kelly, additional, Sakita, Neusa Keico, additional, Badue Pereira, María Fernanda, additional, Leal, Gabriela Nunes, additional, Guarnizo, Pilar, additional, Huertas-Quiñones, Manuel, additional, López, Pio, additional, Deseda-Tous, Jaime, additional, Pujadas, Mónica, additional, Soza, Guillermo, additional, Cerda, Carolina, additional, López-Medina, Issa Lorena, additional, Hernández-Magaña, Rafael, additional, Passos, Saulo Duarte, additional, Rubio-Pérez, Nadina, additional, García-Rodríguez, Fernando, additional, Martínez-Ramírez, Rogelio, additional, Rodríguez-Muñoz, Lorena, additional, Flores-Hernández, Karina, additional, Díaz-Díaz, Alejandro, additional, Mesa-Monsalve, Juan G., additional, Somarriba, María Mercedes, additional, and de Lara-Huerta, Jesús, additional

Published
2023
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13. Multinational prospective study of incidence and risk factors for central-line–associated bloodstream infections in 728 intensive care units of 41 Asian, African, Eastern European, Latin American, and Middle Eastern countries over 24 years

Author

Rosenthal, Victor Daniel, primary, Yin, Ruijie, additional, Myatra, Sheila Nainan, additional, Memish, Ziad A., additional, Rodrigues, Camilla, additional, Kharbanda, Mohit, additional, Valderrama-Beltran, Sandra Liliana, additional, Mehta, Yatin, additional, Afeef Al-Ruzzieh, Majeda, additional, Aguirre-Avalos, Guadalupe, additional, Guclu, Ertugrul, additional, Gan, Chin Seng, additional, Jiménez Alvarez, Luisa Fernanda, additional, Chawla, Rajesh, additional, Hlinkova, Sona, additional, Arjun, Rajalakshmi, additional, Agha, Hala Mounir, additional, Zuniga Chavarria, Maria Adelia, additional, Davaadagva, Narangarav, additional, Lai, Yin Hoong, additional, Gomez, Katherine, additional, Aguilar-de-Moros, Daisy, additional, Tai, Chian-Wern, additional, Sassoe Gonzalez, Alejandro, additional, Aguilar Moreno, Lina Alejandra, additional, Sandhu, Kavita, additional, Janc, Jarosław, additional, Aleman Bocanegra, Mary Cruz, additional, Yildizdas, Dincer, additional, Cano Medina, Yuliana Andrea, additional, Villegas Mota, Maria Isabel, additional, Omar, Abeer Aly, additional, Duszynska, Wieslawa, additional, El-Kholy, Amani Ali, additional, Alkhawaja, Safaa Abdulaziz, additional, Florin, George Horhat, additional, Medeiros, Eduardo Alexandrino, additional, Tao, Lili, additional, Tumu, Nellie, additional, Elanbya, May Gamar, additional, Dongol, Reshma, additional, Mioljević, Vesna, additional, Raka, Lul, additional, Dueñas, Lourdes, additional, Carreazo, Nilton Yhuri, additional, Dendane, Tarek, additional, Ikram, Aamer, additional, Kardas, Tala, additional, Petrov, Michael M., additional, Bouziri, Asma, additional, Viet-Hung, Nguyen, additional, Belskiy, Vladislav, additional, Elahi, Naheed, additional, Salgado, Estuardo, additional, and Jin, Zhilin, additional

Published
2023
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15. Multinational prospective cohort study of rates and risk factors for ventilator-associated pneumonia over 24 years in 42 countries of Asia, Africa, Eastern Europe, Latin America, and the Middle East: Findings of the International Nosocomial Infection Control Consortium (INICC)

Author

Rosenthal, Victor Daniel, primary, Jin, Zhilin, additional, Memish, Ziad A., additional, Rodrigues, Camilla, additional, Myatra, Sheila Nainan, additional, Kharbanda, Mohit, additional, Valderrama-Beltran, Sandra Liliana, additional, Mehta, Yatin, additional, Daboor, Mohammad Abdellatif, additional, Todi, Subhash Kumar, additional, Aguirre-Avalos, Guadalupe, additional, Guclu, Ertugrul, additional, Gan, Chin Seng, additional, Jiménez Alvarez, Luisa Fernanda, additional, Chawla, Rajesh, additional, Hlinkova, Sona, additional, Arjun, Rajalakshmi, additional, Agha, Hala Mounir, additional, Zuniga Chavarria, Maria Adelia, additional, Davaadagva, Narangarav, additional, Mohd Basri, Mat Nor, additional, Gomez, Katherine, additional, Aguilar De Moros, Daisy, additional, Tai, Chian-Wern, additional, Sassoe Gonzalez, Alejandro, additional, Aguilar Moreno, Lina Alejandra, additional, Sandhu, Kavita, additional, Janc, Jarosław, additional, Aleman Bocanegra, Mary Cruz, additional, Yildizdas, Dincer, additional, Cano Medina, Yuliana Andrea, additional, Villegas Mota, Maria Isabel, additional, Omar, Abeer Aly, additional, Duszynska, Wieslawa, additional, BelKebir, Souad, additional, El-Kholy, Amani Ali, additional, Abdulaziz Alkhawaja, Safaa, additional, Horhat Florin, George, additional, Medeiros, Eduardo Alexandrino, additional, Tao, Lili, additional, Tumu, Nellie, additional, Elanbya, May Gamar, additional, Dongol, Reshma, additional, Mioljević, Vesna, additional, Raka, Lul, additional, Dueñas, Lourdes, additional, Carreazo, Nilton Yhuri, additional, Dendane, Tarek, additional, Ikram, Aamer, additional, Kanj, Souha S., additional, Petrov, Michael M., additional, Bouziri, Asma, additional, Hung, Nguyen Viet, additional, Belskiy, Vladislav, additional, Elahi, Naheed, additional, Bovera, María Marcela, additional, and Yin, Ruijie, additional

Published
2023
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16. Factors Associated With Hospitalization or Intensive Care Admission in Children With COVID-19 in Latin America

Author

López-Medina, Eduardo, primary, Camacho-Moreno, German, additional, Brizuela, Martin E., additional, Dávalos, Diana M., additional, Torres, Juan Pablo, additional, Ulloa-Gutierrez, Rolando, additional, López, Pio, additional, Debbag, Roberto, additional, Pérez, Paola, additional, Patiño, Jaime, additional, Norero, Ximena, additional, Mariño, Cristina, additional, Luengas, Miguel A., additional, Ensinck, Gabriela, additional, Daza, Carlos, additional, Luciani, Kathia, additional, Quintana Kuhner, Paola, additional, Rodriguez, Mónica, additional, Rodríguez-Auad, Juan Pablo, additional, Estrada-Villarroel, Alejandra, additional, Carnevale, Mayli, additional, Mantese, Orlando Cesar, additional, Berezin, Eitan N., additional, Castillo, José Iván, additional, Mascareñas, Abiel, additional, Jimenez-Zambrano, Andrea, additional, Dueñas, Lourdes, additional, Melgar, Mario, additional, Galvez, Nancy, additional, Cantor, Erika, additional, and Asturias, Edwin J., additional

Published
2022
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17. Geología del cuadrángulo de Bolívar (hojas 15h1, 15h2, 15h3, 15h4) - [Boletín L 40]

Author

Soaña Condori, Jovita, Chumpitaz Ramírez, Marco Antonio, Gómez Cahuaya, Elmer Wilson, Choquehuanca Condori, Sandra, and Cacya Dueñas, Lourdes

Subjects
Rocas intrusivas, Geología económica, Geología regional, Rocas ígneas, Estratigrafía, purl.org/pe-repo/ocde/ford#1.05.06 [http], Geología, Cuadrángulo de Bolívar, Geología estructural, purl.org/pe-repo/ocde/ford#1.05.00 [http]
Abstract

78 páginas El presente boletín geológico tiene como objetivo contribuir con información geológica del territorio peruano mediante la actualización de la Carta Geológica Nacional a escala 1:50 000 del cuadrángulo de Bolívar. La geomorfología incluye de oeste a este parte de la Cordillera Occidental y Oriental, Zona Intercordillerana, Valle del río Marañón y Zona Subandina, que son disectadas, en dirección noroeste–sureste, por el valle principal del río Marañón y quebradas paralelas como Longotea, Chilca Pampa, Llihuin, y otras quebradas en dirección oeste–este, por los valles de los ríos Crisnejas, Miriles, Quinua Huayco, Cujibamba, Ñamin y Tepna. Las unidades estratigráficas expuestas incluyen el basamento metamórfico del Proterozoico, sobre estas y en discordancia se tiene areniscas del Grupo Ambo, areniscas del Grupo Ambo, los depósitos piroclásticos y lavas de la Formación Lavasen; sobre la secuencia de la Formación Lavasen, sobreyace el Grupo Mitu perteneciente al Pérmico - Triásico. El paso al Triásico y Jurásico está dado por el Grupo Pucará. Parte del Cretácico está representado por el Grupo Goyllarisquizga. Sobre esta secuencia, yacen los estratos calcáreos de la Formación Chúlec, sobre esta unidad yace la Formación Pariatambo en posición concordante. Sobre la Formación Pariatambo sobreyace el Grupo Pulluicana, esta unidad subyace el Grupo Quilquiñán en posición concordante. La Formación Cajamarca sobreyace al Grupo Quilquiñan y subyace a las capas rojas de la Formación Chota. Se realizaron cambios al oeste del cuadrángulo, en las rocas cretácicas sedimentarias, las fallas y los contactos litológicos, definidos entre las formaciones Pulluicana, Quilquiñán, Cajamarca, Celendín y Chota; al norte y noreste, entre las localidades de Pauca, Camish y Amante. Así mismo, al suroeste del cuadrángulo, también se realizó la actualización del cuadrángulo entre el río Chuzgón, al noreste de la localidad de Sitacocha y Hualango. Al sur y este de la localidad de San Juan, es cartografiado el Grupo Goyllarisquizga, la Formación Chúlec y la Formación Chota. Se constata los afloramientos en posición discordante entre el Complejo del Marañón y el Grupo Goyllarisquizga, a esta unidad le sobreyace en posición concordante las formaciones Chúlec - Pariatambo, son formaciones que subyacen al Grupo Pulluicana. En esta zona la Formación Chota; sobreyace al Grupo Pulluicana. Forman anticlinales y sinclinales con dirección noroeste-sureste. Al norte del cuadrángulo, los contactos litológicos son definidos y modificados entre las formaciones Pulluicana, Chúlec, Chota, entre las localidades de Lucma Huayco, a lo largo de la quebrada Longotea. Al este de la localidad de Chahuín, aflora el Complejo Metamórfico del Marañón; es instruido por la Unidad Lavador–Granodiorita. Además, la Unidad Lavador está en contacto de falla normal con el Grupo Pulluicana y sobre esta secuencia sobreyace la Formación Chota. También, se realiza cambios relevantes al extremo noreste del cuadrángulo. Al este de la quebrada Quincuyacu, afloran rocas del Grupo Mitu y Grupo Pucará en contacto de falla inversa. Por otra parte, en la parte central del cuadrángulo, entre la localidad Huipia, camino a la hacienda Pana, aflora la Formación Chambará, la cual sobreyace al Grupo Mitu, en contacto de falla inversa con la Formación Lavasen. De la actualización realizada desde la localidad de Bambamarca hacia el río Tepna, aflora en contacto de falla el Grupo Goyllarisquizga. Asimismo, se distingue la Formación Chambará y el Grupo Ambo en contacto de falla con el Grupo Mitu; antes, no se registró información del Grupo Ambo. La Formación Chota sobreyace en posición discordante sobre el Grupo Pucará; en el cerro Patanya aflora en contacto de falla inversa con el Grupo Mitu. En el caso de las rocas ígneas, afloran al oeste y suroeste de la localidad de Bolívar. Son intrusivos de variada composición mineralógica, varían de máficos a félsicos. Algunos contactos litológicos son modificados, como en la localidad de Huipia, en la que aflora un stock de composición félsica que afecta a la Formación Lavasen y a la Unidad Enaben. Por otra parte, es procesada la data geoquímica de estudios anteriores realizados por Sánchez (1995, 2006). La evolución tectónica se manifestó en varios ciclos, desde el Neoproterozoico, Paleozoico (Pérmico-Carbonífero), Mesozoico (Triásico, Jurásico, Cretácico) y Cenozoico (Paleógeno, Neógeno y Cuaternario), debido al fuerte plegamiento y por la presencia de fallas inversas y normales.

Published
2021

18. Presentation and Outcomes of Kawasaki Disease in Latin American Infants Younger Than 6 Months of Age: A Multinational Multicenter Study of the REKAMLATINA Network

Author

Moreno, Elizabeth, primary, Garcia, S. Diana, additional, Bainto, Emelia, additional, Salgado, Andrea P., additional, Parish, Austin, additional, Rosellini, Benjamin D., additional, Ulloa-Gutierrez, Rolando, additional, Garrido-Garcia, Luis M., additional, Dueñas, Lourdes, additional, Estripeaut, Dora, additional, Luciani, Kathia, additional, Rodríguez-Quiroz, Francisco J., additional, del Aguila, Olguita, additional, Camacho-Moreno, Germán, additional, Gómez, Virgen, additional, Viviani, Tamara, additional, Alvarez-Olmos, Martha I., additional, de Souza Marques, Heloisa Helena, additional, Faugier-Fuentes, Enrique, additional, Saltigeral-Simental, Patricia, additional, López-Medina, Eduardo, additional, Miño-León, Greta, additional, Beltrán, Sandra, additional, Martínez-Medina, Lucila, additional, Pirez, Maria C., additional, Cofré, Fernanda, additional, and Tremoulet, Adriana H., additional

Published
2020
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19. Epidemiología del dengue en Centroamérica y República Dominicana

Author

Ávila-Agüero, María L, Camacho-Badilla, Kattia, Brea-Del-Castillo, José, Cerezo, Lizbeth, Dueñas, Lourdes, Luque, Marco, Melgar, Mario, and Rocha, Crisanta

Subjects
Dengue, República Dominicana, Dominican Republic, incidence, Centroamérica, epidemiology, Central America, mortality, incidencia, letalidad, epidemiología
Abstract

Resumen Introducción: Centroamérica experimenta una alta carga de la enfermedad por dengue aportando cerca de 8% de todos los casos del continente. Este trabajo reporta la epidemiología del dengue en la subregión en un período de 10 años. Objetivos: Documentar la epidemiología del dengue en Centro América y República Dominicana. Material y Métodos: Período de estudio: años 2005-2014. Se recopilaron y analizaron los datos de casos y muertes por dengue de los países de Centro América y República Dominicana, reportados por los Ministerios de Salud y se corroboró con los datos publicados en los boletines en línea y la base de datos interactiva de la Organización Panamericana de la Salud (OPS). Se obtuvieron estadísticas poblacionales de los Institutos Nacionales de Estadística y Censo de cada país. Resultados: Durante el período de estudio fueron notificados 1.118.464 casos de dengue. Reportados 32.431 casos graves, 888 personas fallecidas. La letalidad por caso de dengue fue en promedio 0,08%. Los cuatro serotipos de dengue circularon durante el decenio estudiado. Discusión: La información clínica y epidemiológica, indica tasas de incidencia alta, que han fluctuado en los últimos años, con co-circulación significativa de varios serotipos a la vez. Conclusiones: Se identificaron diferencias notorias en la recolección de datos de la vigilancia entre países. Se determinó un patrón epidemiológico heterogéneo. Background: Central America experiences a high burden of dengue reporting about 8% of all cases in the continent. This work reports the epidemiology of dengue in the sub region in a 10 years period. Aim: To describe the epidemiology of dengue in Central America and the Dominican Republic. Methods: Study period from 2005 to 2014. The data on dengue cases and deaths of the countries of Central America and the Dominican Republic, reported by the Ministries of Health, were compiled and analyzed and corroborated with the data published in the online bulletins and the interactive database of the Pan American Health Organization (PAHO). Population statistics were obtained from the National Statistics and Census Institutes of each country. Results: During the study period, 1,118,464 cases of dengue were notified. There were 32,431 serious cases reported, 888 people died. The lethality per case of dengue was on average 0.08%. The four dengue serotypes circulated during the decade analyzed. Discussion: Clinical and epidemiological information indicates high incidence rates, which have fluctuated in recent years, with significant co-circulation of several serotypes at the same time. Conclusions: Notorious surveillance data collection differences were identified between countries, determining a heterologous epidemiological pattern.

Published
2019

29. Kawasaki Disease (KD) in Children (Ch) Older Than 5 Years of Age Among 20 Latin American (LA) Countries: A Prospective Multinational Multicenter Study of the REKAMLATINA Network

Author

Ulloa-Gutierrez, Rolando, primary, Garrido-García, Luis M, additional, Estripeaut, Dora, additional, Rodríguez, Francisco J, additional, Saltigeral-Simental, Patricia, additional, Águila, Olguita Del, additional, Miño, Greta, additional, Luque, Marco T, additional, Collia, Adrián, additional, Faugier-Fuentes, Enrique, additional, Marques, Heloisa Helena De Sousa, additional, Álvarez-Olmos, Martha I, additional, Luciani, Kathia, additional, Pirez, María C, additional, Cofre, Fernanda, additional, Camacho-Moreno, German, additional, Gomez, Virgen, additional, Yamazaki-Nakashimada, Marco a, additional, López-Gallegos, Diana, additional, Calvache-Burbano, Angélica, additional, Avila-Aguero, María L, additional, Izquierdo, Giannina, additional, Camacho-Badilla, Kattia, additional, Soriano-Fallas, Alejandra, additional, Valverde, Kathia, additional, Rodriguez-Herrera, Raymundo, additional, Chacon-Cruz, Enrique, additional, Fernández, Antonio, additional, Martínez-Medina, Lucila, additional, Gámez-González, Luisa Berenise, additional, Dueñas, Lourdes, additional, Pérez-Camacho, Paola, additional, Grazioso, Carlos, additional, Franco, Lorena, additional, Bueno, Nora, additional, Beltán, Sandra, additional, Narváez, Jorge a Vázquez, additional, Salgado, Andrea P., additional, Tremoulet, Adriana H., additional, and Members, Study Group, additional

Published
2016
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32. Impact of social determinants of health on the outcomes of Latin American children with Multisystem Inflammatory Syndrome (MIS-C).

Author

Buonsenso D, Camporesi A, Sawaya C, Ulloa-Gutierrez R, Faugier-Fuentes E, Dueñas L, Paternina-de la Ossa RA, Llamas-Guillén BA, Gámez-González LB, Gálvez-Rafael N, Gatica A, Saltigeral-Simental P, Cuatecontzi-Romero A, Almeida FJ, Cuan S, Zapata-Yarlequé EH, Beltrán S, Reina-Bautista E, Collia A, Ivankovich-Escoto G, Fernández-Sarmiento J, and Tremoulet AH

Subjects
Adolescent, Child, Child, Preschool, Female, Humans, Infant, Male, COVID-19, Latin America epidemiology, Retrospective Studies, Social Determinants of Health statistics & numerical data, Systemic Inflammatory Response Syndrome epidemiology
Abstract

Importance: There is growing understanding that Social Determinants of Health (SDH) impact on the outcomes of different pediatric conditions. We aimed to determine whether SDH affect the severity of MIS-C., Design: Retrospective cohort study, 2021-2023. Children and adolescents with MIS-C younger than 18 years of age fulfilling the MIS-C CDC definition within the REKAMLATINA network were invited to participate. We assessed the impact of SDH on the risk of children with MIS-C to be diagnosed with shock, need of inotropes, respiratory support, transfusion, and death., Results: Two hundred and seventy seven patients from 30 centers in 13 countries were included. Of them, 241 children from the four most-represented countries were included in the final analysis. Food insecurity, higher distance from a health center, not possessing a private vehicle to transport the patient to hospital, and having a home in poor condition, were associated with low LVEF, need of transfusion, shock, and need for respiratory support, when controlling for age, BMI, and ethnicity. The Score of Social Disadvantage was associated with Shock (OR: 1.35, P: 0.011, 95% CI: 1.07-1.71), Respiratory support (OR: 1.39, P: 0.005, 95% CI: 1.1-1.75), Transfusion (OR: 1.63, P0.013, 95% CI 1.1-2.41), but not death (OR: 0.76, P: 0.38, 95% CI: 0.41-1.40)., Conclusions: Among a large cohort of Latin American children with MIS-C, SDH negatively affect outcomes. These findings reinforce the need for better investigation of the role of SDH in MIS-C and other inflammatory conditions and may guide public health interventions., (© 2024 The Author(s). Pediatric Pulmonology published by Wiley Periodicals LLC.)

Published
2025
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33. Use of Adjunctive Therapy in Acute Kawasaki Disease in Latin America.

Author

Fortuna-Reyna B, Bainto EV, Ulloa-Gutierrez R, Garrido-García LM, Estripeaut D, Del Águila O, Gómez V, Faugier-Fuentes E, Miño-León G, Beltrán S, Cofré F, Chacón-Cruz E, Saltigeral-Simental P, Martínez-Medina L, Dueñas L, Luciani K, Rodríguez-Quiroz FJ, Camacho-Moreno G, Viviani T, Alvarez-Olmos MI, Marques HHS, López-Medina E, Pirez MC, and Tremoulet AH

Abstract

Objective: To characterize the use of adjunctive therapy in Kawasaki disease (KD) in Latin America. Methods: The study included 1,418 patients from the Latin American KD Network (REKAMLATINA) treated for KD between January 1, 2009, and May 31, 2017. Results: Of these patients, 1,152 received only a single dose of IVIG, and 266 received additional treatment. Age at onset was similar in both groups (median 2 vs. 2.2 years, respectively). The majority of patients were male (58 vs. 63.9%) and were hospitalized with the first 10 days of fever (85.1 vs. 84.2%). The most common adjunctive therapy administered was steroids for IVIG-resistance, followed by additional doses of IVIG. The use of biologics such as infliximab was limited. KD patients who received adjunctive therapy were more likely to have a lower platelet count and albumin level as well as a higher Z score of the coronary arteries. Conclusion: This is the first report of adjunctive therapies for KD across Latin America. IVIG continues to be the initial and resistance treatment, however, steroids are also used and to a lesser extent, biological therapy such as infliximab. Future studies should address the barriers to therapy in children with acute KD throughout Latin America., (Copyright © 2020 Fortuna-Reyna, Bainto, Ulloa-Gutierrez, Garrido-García, Estripeaut, del Águila, Gómez, Faugier-Fuentes, Miño-León, Beltrán, Cofré, Chacón-Cruz, Saltigeral-Simental, Martínez-Medina, Dueñas, Luciani, Rodríguez-Quiroz, Camacho-Moreno, Viviani, Alvarez-Olmos, Marques, López-Medina, Pirez, Tremoulet and the Kawasaki Disease REKAMLATINA Network Study Group.)

Published
2020
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34. [Epidemiology of dengue in Central America and the Dominican Republic].

Author

Ávila-Agüero ML, Camacho-Badilla K, Brea-Del-Castillo J, Cerezo L, Dueñas L, Luque M, Melgar M, and Rocha C

Subjects
Central America epidemiology, Dominican Republic epidemiology, Humans, Incidence, Pan American Health Organization, Dengue epidemiology
Abstract

Background: Central America experiences a high burden of dengue reporting about 8% of all cases in the continent. This work reports the epidemiology of dengue in the sub region in a 10 years period., Aim: To describe the epidemiology of dengue in Central America and the Dominican Republic., Methods: Study period from 2005 to 2014. The data on dengue cases and deaths of the countries of Central America and the Dominican Republic, reported by the Ministries of Health, were compiled and analyzed and corroborated with the data published in the online bulletins and the interactive database of the Pan American Health Organization (PAHO). Population statistics were obtained from the National Statistics and Census Institutes of each country., Results: During the study period, 1,118,464 cases of dengue were notified. There were 32,431 serious cases reported, 888 people died. The lethality per case of dengue was on average 0.08%. The four dengue serotypes circulated during the decade analyzed., Discussion: Clinical and epidemiological information indicates high incidence rates, which have fluctuated in recent years, with significant co-circulation of several serotypes at the same time., Conclusions: Notorious surveillance data collection differences were identified between countries, determining a heterologous epidemiological pattern.

Published
2019
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