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5. Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification

Author

Millen, Rosemary, De Kort, Willem W.B., Koomen, Mandy, van Son, Gijs J.F., Gobits, Roán, Penning de Vries, Bas, Begthel, Harry, Zandvliet, Maurice, Doornaert, Patricia, Raaijmakers, Cornelis P.J., Geurts, Maarten H., Elias, Sjoerd G., van Es, Robert J.J., de Bree, Remco, Devriese, Lot A., Willems, Stefan M., Kranenburg, Onno, Driehuis, Else, and Clevers, Hans

Published
2023
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7. Online adaptive MR-guided radiotherapy: Conformity of contour adaptation for prostate cancer, rectal cancer and lymph node oligometastases among radiation therapists and radiation oncologists

Author

Rasing, Marnix J.A., Sikkes, Gonda G., Vissers, Nicole G.P.M., Kotte, Alexis N.T.J., Boudewijn, Joske H., Doornaert, Patricia A.H., Eppinga, Wietse S.C., Intven, Martijn, Rutgers, Reijer H.A., Scheeren, Annick, Snoeren, Louk M.W., Vlig, Tiny B., van der Voort van Zyp, Jochem R.N., Wijkhuizen, Lisa M., van Rossum, Peter S.N., Peters, Max, and Jürgenliemk-Schulz, Ina M.

Published
2022
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10. Cost-utility and cost-effectiveness of a guided self-help head and neck exercise program for patients treated with total laryngectomy: Results of a multi-center randomized controlled trial

Author

Jansen, Femke, Coupé, Veerle M.H., Eerenstein, Simone E.J., Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Published
2021
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11. Detectability and intra-fraction motion of individual elective lymph nodes in head and neck cancer patients on the Magnetic Resonance Image guided linear accelerator

Author

Onderzoek Radiotherapie, MS Radiotherapie, Cancer, Radiotherapie, Experimentele klinische fysica, Klinische Fysica RT, Reinders, Floris C.J., de Ridder, Mischa, Stijnman, Peter R.S., Doornaert, Patricia A.H., Raaijmakers, Cornelis P.J., Philippens, Marielle E.P., Onderzoek Radiotherapie, MS Radiotherapie, Cancer, Radiotherapie, Experimentele klinische fysica, Klinische Fysica RT, Reinders, Floris C.J., de Ridder, Mischa, Stijnman, Peter R.S., Doornaert, Patricia A.H., Raaijmakers, Cornelis P.J., and Philippens, Marielle E.P.

Published
2024

14. Improved Delineation with Diffusion Weighted Imaging for Laryngeal and Hypopharyngeal Tumors Validated with Pathology

Author

Smits, Hilde J.G., primary, Raaijmakers, Cornelis P. J., additional, de Ridder, Mischa, additional, Gouw, Zeno A. R., additional, Doornaert, Patricia A. H., additional, Pameijer, Frank A., additional, Lodeweges, Joyce E., additional, Ruiter, Lilian N., additional, Kuijer, Koen M., additional, Schakel, Tim, additional, de Bree, Remco, additional, Dankbaar, Jan W., additional, Breimer, Gerben E., additional, Terhaard, Chris H.J., additional, Willems, Stefan M., additional, and Philippens, Marielle E. P., additional

Published
2024
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16. Magnetic Resonance-based Response Assessment and Dose Adaptation in Human Papilloma Virus Positive Tumors of the Oropharynx treated with Radiotherapy (MR-ADAPTOR): An R-IDEAL stage 2a-2b/Bayesian phase II trial

Author

Bahig, Houda, Yuan, Ying, Mohamed, Abdallah S.R., Brock, Kristy K., Ng, Sweet Ping, Wang, Jihong, Ding, Yao, Hutcheson, Kate, McCulloch, Molly, Balter, Peter A., Lai, Stephen Y., Al-Mamgani, Abrahim, Sonke, Jan-Jakob, van der Heide, Uulke A., Nutting, Christopher, Li, X. Allen, Robbins, Jared, Awan, Mussadiq, Karam, Irene, Newbold, Katherine, Harrington, Kevin, Oelfke, Uwe, Bhide, Shreerang, Philippens, Marielle E.P., Terhaard, Chris H.J., McPartlin, Andrew J., Blanchard, Pierre, Garden, Adam S., Rosenthal, David I., Gunn, Gary B., Phan, Jack, Cazoulat, Guillaume, Aristophanous, Michalis, McSpadden, Kelli K., Garcia, John A., van den Berg, Cornelis A.T., Raaijmakers, Cornelis P.J., Kerkmeijer, Linda, Doornaert, Patricia, Blinde, Sanne, Frank, Steven J., and Fuller, Clifton D.

Published
2018
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20. Comprehensive Quantitative Evaluation of Variability in Magnetic Resonance-Guided Delineation of Oropharyngeal Gross Tumor Volumes and High-Risk Clinical Target Volumes: An R-IDEAL Stage 0 Prospective Study

Author

Cardenas, Carlos E., Blinde, Sanne E., Mohamed, Abdallah S. R., Ng, Sweet Ping, Raaijmakers, Cornelis, Philippens, Marielle, Kotte, Alexis, Al-Mamgani, Abrahim A., Karam, Irene, Thomson, David J., Robbins, Jared, Newbold, Kate, Fuller, Clifton D., Terhaard, Chris, Bahig, Houda, Blanchard, Pierre, Dehnad, Homan, Doornaert, Patricia, Elhalawani, Hesham, Frank, Steven J., Garden, Adam, Gunn, G. Brandon, Hamming-Vrieze, Olga, Kamal, Mona, Kasperts, Nicolien, Lee, Lip Wai, McDonald, Brigid A., McPartlin, Andrew, Meheissen, Mohamed AM, Morrison, William H., Navran, Arash, Nutting, Christopher M., Pameijer, Frank, Phan, Jack, Poon, Ian, Rosenthal, David I, Smid, Ernst J., and Sykes, Andrew J.

Subjects
Observer Variation, Cancer Research, Magnetic Resonance Spectroscopy, Radiation, Radiotherapy Planning, Computer-Assisted, Magnetic Resonance Imaging, Article, Tumor Burden, Oropharyngeal Neoplasms, Oncology, Head and Neck Neoplasms, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Retrospective Studies
Abstract

Tumor and target volume manual delineation remains a challenging task in head and neck cancer radiation therapy. The purpose of this study was to conduct a multi-institutional evaluation of manual delineations of gross tumor volume (GTV), high-risk clinical target volume (CTV), parotids, and submandibular glands on treatment simulation magnetic resonance scans of patients with oropharyngeal cancer.We retrospectively collected pretreatment T1-weighted, T1-weighted with gadolinium contrast, and T2-weighted magnetic resonance imaging scans for 4 patients with oropharyngeal cancer under an institution review board-approved protocol. We provided the scans to 26 radiation oncologists from 7 international cancer centers that participated in this delineation study. We also provide the patients' clinical history and physical examination findings, along with a medical photographic image and radiologic results. We used both the Simultaneous Truth and Performance Level Estimation algorithm and pair-wise comparisons of the contours, using overlap/distance metrics. Lastly, to assess experience and CTV delineation institutional practices, we had participants complete a brief questionnaire.Large variability was measured between observers' delineations for GTVs and CTVs. The mean Dice similarity coefficient values across all physicians' delineations for GTVp, GTVn, CTVp, and CTVn were 0.77, 0.67, 0.77, and 0.69, respectively, for Simultaneous Truth and Performance Level Estimation algorithm comparison, and 0.67, 0.60, 0.67, and 0.58, respectively, for pair-wise analysis. Normal tissue contours were defined more consistently when considering overlap/distance metrics. The median radiation oncology clinical experience was 7 years. The median experience delineating on magnetic resonance imaging was 3.5 years. The GTV-to-CTV margin used was 10 mm for 6 of 7 participant institutions. One institution used 8 mm, and 3 participants (from 3 different institutions) used a margin of 5 mm.The data from this study suggests that appropriate guidelines, contouring quality assurance sessions, and training are still needed for the adoption of magnetic resonance-based treatment planning for head and neck cancers. Such efforts should play a critical role in reducing delineation variation and ensure standardization of target design across clinical practices.

Published
2022

21. Supplementary Table S2 from Improved Recurrence-Free Survival with ARCON for Anemic Patients with Laryngeal Cancer

Author

Janssens, Geert O., primary, Rademakers, Saskia E., primary, Terhaard, Chris H., primary, Doornaert, Patricia A., primary, Bijl, Hendrik P., primary, van den Ende, Piet, primary, Chin, Alim, primary, Takes, Robert P., primary, de Bree, Remco, primary, Hoogsteen, Ilse J., primary, Bussink, Johan, primary, Span, Paul N., primary, and Kaanders, Johannes H., primary

Published
2023
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22. Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification

Author

Interne geneeskunde GD, CS_Cancer, Millen, Rosemary, De Kort, Willem W B, Koomen, Mandy, van Son, Gijs J F, Gobits, Roán, Penning de Vries, Bas, Begthel, Harry, Zandvliet, Maurice, Doornaert, Patricia, Raaijmakers, Cornelis P J, Geurts, Maarten H, Elias, Sjoerd G, van Es, Robert J J, de Bree, Remco, Devriese, Lot A, Willems, Stefan M, Kranenburg, Onno, Driehuis, Else, Clevers, Hans, Interne geneeskunde GD, CS_Cancer, Millen, Rosemary, De Kort, Willem W B, Koomen, Mandy, van Son, Gijs J F, Gobits, Roán, Penning de Vries, Bas, Begthel, Harry, Zandvliet, Maurice, Doornaert, Patricia, Raaijmakers, Cornelis P J, Geurts, Maarten H, Elias, Sjoerd G, van Es, Robert J J, de Bree, Remco, Devriese, Lot A, Willems, Stefan M, Kranenburg, Onno, Driehuis, Else, and Clevers, Hans

Published
2023

23. Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification

Author

MKA/BT Onderzoek, Pathologie Groep Brosens, Epi Kanker Team C, MS Radiotherapie, Cancer, Klinische Fysica RT, JC onderzoeksprogramma Kanker, DHS 3D Lab, MS Hoofd-Hals Chirurgische Oncologie, MS Medische Oncologie, Pathologie Pathologen staf, Lab Translational Oncology, Regenerative Medicine and Stem Cells, CMM, Hubrecht Institute with UMC, Millen, Rosemary, De Kort, Willem W.B., Koomen, Mandy, van Son, Gijs J.F., Gobits, Roán, Penning de Vries, Bas, Begthel, Harry, Zandvliet, Maurice, Doornaert, Patricia, Raaijmakers, Cornelis P.J., Geurts, Maarten H., Elias, Sjoerd G., van Es, Robert J.J., de Bree, Remco, Devriese, Lot A., Willems, Stefan M., Kranenburg, Onno, Driehuis, Else, Clevers, Hans, MKA/BT Onderzoek, Pathologie Groep Brosens, Epi Kanker Team C, MS Radiotherapie, Cancer, Klinische Fysica RT, JC onderzoeksprogramma Kanker, DHS 3D Lab, MS Hoofd-Hals Chirurgische Oncologie, MS Medische Oncologie, Pathologie Pathologen staf, Lab Translational Oncology, Regenerative Medicine and Stem Cells, CMM, Hubrecht Institute with UMC, Millen, Rosemary, De Kort, Willem W.B., Koomen, Mandy, van Son, Gijs J.F., Gobits, Roán, Penning de Vries, Bas, Begthel, Harry, Zandvliet, Maurice, Doornaert, Patricia, Raaijmakers, Cornelis P.J., Geurts, Maarten H., Elias, Sjoerd G., van Es, Robert J.J., de Bree, Remco, Devriese, Lot A., Willems, Stefan M., Kranenburg, Onno, Driehuis, Else, and Clevers, Hans

Published
2023

24. Oncological outcome of vocal cord-only radiotherapy for cT1-T2 glottic laryngeal squamous cell carcinoma

Author

MS Radiotherapie, Cancer, MS Hoofd-Hals Chirurgische Oncologie, MS KNO, Radiotherapie, Fysica Radiotherapie Research, de Ridder, Mischa, Rijken, Johannes A., Smits, Hilde J.G., Smid, Ernst J., Doornaert, Patricia A.H., de Bree, Remco, MS Radiotherapie, Cancer, MS Hoofd-Hals Chirurgische Oncologie, MS KNO, Radiotherapie, Fysica Radiotherapie Research, de Ridder, Mischa, Rijken, Johannes A., Smits, Hilde J.G., Smid, Ernst J., Doornaert, Patricia A.H., and de Bree, Remco

Published
2023

25. Individual elective lymph node irradiation for the reduction of complications in head and neck cancer patients (iNode): A phase-I feasibility trial protocol

Author

Onderzoek Radiotherapie, MS Radiotherapie, Cancer, Klinische Fysica RT, Reinders, Floris C.J., de Ridder, Mischa, Doornaert, Patricia A.H., P.J. Raaijmakers, Cornelis, Philippens, Marielle E.P., Onderzoek Radiotherapie, MS Radiotherapie, Cancer, Klinische Fysica RT, Reinders, Floris C.J., de Ridder, Mischa, Doornaert, Patricia A.H., P.J. Raaijmakers, Cornelis, and Philippens, Marielle E.P.

Published
2023

28. Swallowing sparing intensity modulated radiotherapy (SW-IMRT) in head and neck cancer: Clinical validation according to the model-based approach

Author

Christianen, Miranda E.M.C., van der Schaaf, Arjen, van der Laan, Hans Paul, Verdonck-de Leeuw, Irma M., Doornaert, Patricia, Chouvalova, Olga, Steenbakkers, Roel J.H.M., Leemans, Charles René, Oosting, Sjoukje F., van der Laan, Bernard F.A.M., Roodenburg, Jan L.N., Slotman, Ben J., Bijl, Hendrik P., and Langendijk, Johannes A.

Published
2016
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32. Prophylactic exercises among head and neck cancer patients during and after swallowing sparing intensity modulated radiation: adherence and exercise performance levels of a 12-week guided home-based program

Author

Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., Witte, Birgit I., Aalders, Yke J., de Goede, Cees J. T., de Bree, Remco, Doornaert, Patricia, Rietveld, Derek H. F., Buter, Jan, Langendijk, Johannes A., Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Published
2017
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34. Development of a multivariable normal tissue complication probability (NTCP) model for tube feeding dependence after curative radiotherapy/chemo-radiotherapy in head and neck cancer

Author

Wopken, Kim, Bijl, Hendrik P., van der Schaaf, Arjen, van der Laan, Hans Paul, Chouvalova, Olga, Steenbakkers, Roel J.H.M., Doornaert, Patricia, Slotman, Ben J., Oosting, Sjoukje F., Christianen, Miranda E.M.C., van der Laan, Bernard F.A.M., Roodenburg, Jan L.N., René Leemans, C., Verdonck-de Leeuw, Irma M., and Langendijk, Johannes A.

Published
2014
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37. MRI visibility and displacement of elective lymph nodes during radiotherapy in head and neck cancer patients

Author

Onderzoek Radiotherapie, Experimentele klinische fysica, MS Radiotherapie, Cancer, Klinische Fysica RT, Reinders, Floris C J, Stijnman, Peter R S, de Ridder, Mischa, Doornaert, Patricia A H, Raaijmakers, Cornelis P J, Philippens, Marielle E P, Onderzoek Radiotherapie, Experimentele klinische fysica, MS Radiotherapie, Cancer, Klinische Fysica RT, Reinders, Floris C J, Stijnman, Peter R S, de Ridder, Mischa, Doornaert, Patricia A H, Raaijmakers, Cornelis P J, and Philippens, Marielle E P

Published
2022

38. Online adaptive MR-guided radiotherapy: Conformity of contour adaptation for prostate cancer, rectal cancer and lymph node oligometastases among radiation therapists and radiation oncologists

Author

Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Arts-assistenten Radiotherapie, Rasing, Marnix J A, Sikkes, Gonda G, Vissers, Nicole G P M, Kotte, Alexis N T J, Boudewijn, Joske H, Doornaert, Patricia A H, Eppinga, Wietse S C, Intven, Martijn, Rutgers, Reijer H A, Scheeren, Annick, Snoeren, Louk M W, Vlig, Tiny B, van der Voort van Zyp, Jochem R N, Wijkhuizen, Lisa M, van Rossum, Peter S N, Peters, Max, Jürgenliemk-Schulz, Ina M, Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Arts-assistenten Radiotherapie, Rasing, Marnix J A, Sikkes, Gonda G, Vissers, Nicole G P M, Kotte, Alexis N T J, Boudewijn, Joske H, Doornaert, Patricia A H, Eppinga, Wietse S C, Intven, Martijn, Rutgers, Reijer H A, Scheeren, Annick, Snoeren, Louk M W, Vlig, Tiny B, van der Voort van Zyp, Jochem R N, Wijkhuizen, Lisa M, van Rossum, Peter S N, Peters, Max, and Jürgenliemk-Schulz, Ina M

Published
2022

39. Target Definition in MR-Guided Adaptive Radiotherapy for Head and Neck Cancer

Author

MS Radiotherapie, Cancer, Klinische Fysica RT, MS Radiologie, MS Hoofd-Hals Chirurgische Oncologie, Onderzoek Radiotherapie, Ridder, Mischa de, Raaijmakers, Cornelis P J, Pameijer, Frank A, Bree, Remco de, Reinders, Floris C J, Doornaert, Patricia A H, Terhaard, Chris H J, Philippens, Marielle E P, MS Radiotherapie, Cancer, Klinische Fysica RT, MS Radiologie, MS Hoofd-Hals Chirurgische Oncologie, Onderzoek Radiotherapie, Ridder, Mischa de, Raaijmakers, Cornelis P J, Pameijer, Frank A, Bree, Remco de, Reinders, Floris C J, Doornaert, Patricia A H, Terhaard, Chris H J, and Philippens, Marielle E P

Published
2022

40. Association of histological features with laryngeal squamous cell carcinoma recurrences: a population-based study of 1502 patients in the Netherlands

Author

Fysica Radiotherapie Research, Cancer, MS Radiotherapie, Klinische Fysica RT, MS Hoofd-Hals Chirurgische Oncologie, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Pathologie Pathologen staf, Ruiter, Lilian N, van Dijk, Boukje A C, Bruggink, Annette H, Doornaert, Patricia A H, Philippens, Marielle E P, de Bree, Remco, van Gils, Carla H, Willems, Stefan M, Fysica Radiotherapie Research, Cancer, MS Radiotherapie, Klinische Fysica RT, MS Hoofd-Hals Chirurgische Oncologie, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Pathologie Pathologen staf, Ruiter, Lilian N, van Dijk, Boukje A C, Bruggink, Annette H, Doornaert, Patricia A H, Philippens, Marielle E P, de Bree, Remco, van Gils, Carla H, and Willems, Stefan M

Published
2022

41. Additional file 1 of Association of histological features with laryngeal squamous cell carcinoma recurrences: a population-based study of 1502 patients in the Netherlands

Author

Ruiter, Lilian N., van Dijk, Boukje A. C., Bruggink, Annette H., Doornaert, Patricia A. H., Philippens, Marielle E. P., de Bree, Remco, van Gils, Carla H., and Willems, Stefan M.

Abstract

Additional file 1: Supplementary Table 1. Generalizability sample of pathology data extracted from pathology reports compared to initial cohort. A). Basic clinical characteristics of patients for each year of the sample used in this paper (n = 1502). These are the 3656 patients of which 44% of each year pathology data were extracted and CIS were removed. B). Basic clinical characteristics of the total dataset of patients for each year (n = 3380). These are the 3656 patients with reliable linkage between NKR-PALGA minus 276 CIS patients leaving 3380 patients in total. Supplementary Table 2. Histological characteristics, locoregional recurrences and death of patients treated with tumor-positive lymph nodes (n = 205). Supplementary Table 3. Histological characteristics, locoregional recurrences and death of T3/T4 N0/N+ patients treated with TLE or TLE with RT (n = 98). Supplementary Figure 1. Separate multivariable analysis of extracapsular spread, keratinization and PNI+/VI+/Growth pattern. Each separate histological characteristic was corrected for age, gender, sublocalisation and stage/treatment for locoregional recurrence and death of patients with positive lymph nodes (n = 205). Supplementary Figure 2. Univariable analysis of histological characteristics of the primary tumor for locoregional recurrence and death of T3/T4 N0/N+ patients treated with TLE or TLE with RT (n = 98). * p

Published
2022
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45. National Protocol for Model-Based Selection for Proton Therapy in Head and Neck Cancer

Author

Langendijk, Johannes A., primary, Hoebers, Frank J. P., additional, de Jong, Martin A., additional, Doornaert, Patricia, additional, Terhaard, Chris H. J., additional, Steenbakkers, Roel J. H. M., additional, Hamming-Vrieze, Olga, additional, van de Kamer, Jeroen B., additional, Verbakel, Wilko F. A. R., additional, Keskin-Cambay, Fatma, additional, Reitsma, Johannes B., additional, van der Schaaf, Arjen, additional, Boersma, Liesbeth J., additional, and Schuit, Ewoud, additional

Published
2021
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46. Cost-utility and cost-effectiveness of a guided self-help head and neck exercise program for patients treated with total laryngectomy:Results of a multi-center randomized controlled trial

Author

Jansen, Femke, Coupé, Veerle M.H., Eerenstein, Simone E.J., Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, Leemans, C. René, Verdonck-de Leeuw, Irma M., Jansen, Femke, Coupé, Veerle M.H., Eerenstein, Simone E.J., Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Abstract

Objectives: The guided self-help exercise program called In Tune without Cords (ITwC) is effective in improving swallowing problems and communication among patients treated with a total laryngectomy (TL). This study investigated the cost-utility and cost-effectiveness of ITwC. Materials and methods: Patients within 5 years after TL were included in this randomized controlled trial. Patients in the intervention group (n = 46) received access to the self-help exercise program with flexibility, range-of-motion and lymphedema exercises, and a self-care education program. Patients in the control group (n = 46) received access to the self-care education program only. Healthcare utilization (iMCQ), productivity losses (iPCQ), health status (EQ-5D-3L, EORTC QLU-C10D) and swallowing problems (SwalQol) were measured at baseline, 3- and 6-months follow-up. Hospital costs were extracted from medical files. Mean total costs and effects (quality-adjusted life-years (QALYs) or SwalQol score) were compared with regression analyses using bias-corrected accelerated bootstrapping. Results: Mean total costs were non-significantly lower (-€685) and QALYs were significantly higher (+0.06) in the intervention compared to the control group. The probability that the intervention is less costly and more effective was 73%. Sensitivity analyses with adjustment for baseline costs and EQ-5D scores showed non-significantly higher costs (+€119 to +€364) and QALYs (+0.02 to +0.03). A sensitivity analysis using the QLU-C10D to calculate QALYs showed higher costs (+€741) and lower QALYs (-0.01) and an analysis that used the SwalQol showed higher costs (+€232) and higher effects (improvement of 6 points on a 0–100 scale). Conclusion: ITwC is likely to be effective, but possibly at higher expenses. Trial Registration: NTR5255.

Published
2021

47. National protocol for model-based selection for proton therapy in head and neck cancer

Author

Langendijk, Johannes A., Hoebers, Frank J.P., De Jong, Martin A., Doornaert, Patricia, Terhaard, Chris H.J., Steenbakkers, Roel J.H.M., Hamming-Vrieze, Olga, Van De Kamer, Jeroen B., Verbakel, Wilko F.A.R., Keskin-Cambay, Fatma, Reitsma, Johannes B., Van Der Schaaf, Arjen, Boersma, Liesbeth J., Schuit, Ewoud, Langendijk, Johannes A., Hoebers, Frank J.P., De Jong, Martin A., Doornaert, Patricia, Terhaard, Chris H.J., Steenbakkers, Roel J.H.M., Hamming-Vrieze, Olga, Van De Kamer, Jeroen B., Verbakel, Wilko F.A.R., Keskin-Cambay, Fatma, Reitsma, Johannes B., Van Der Schaaf, Arjen, Boersma, Liesbeth J., and Schuit, Ewoud

Abstract

In the Netherlands, the model-based approach is used to identify patients with head and neck cancer who may benefit most from proton therapy in terms of prevention of late radiation-induced side effects in comparison with photon therapy. To this purpose, a National Indication Protocol Proton therapy for Head and Neck Cancer patients (NIPPHNC) was developed, which has been approved by the health care authorities. When patients qualify according to the guidelines of the NIPP-HNC, proton therapy is fully reimbursed. This article describes the procedures that were followed to develop this NIPP-HNC and provides all necessary information to introduce model-based selection for patients with head and neck cancer into routine clinical practice.

Published
2021

48. Magnetic resonance guided elective neck irradiation targeting individual lymph nodes: A new concept

Author

Fysica Radiotherapie Research, MS Radiotherapie, Cancer, Klinische Fysica RT, Reinders, Floris C.J., Heijst, Tristan C.F.van, Mases, Joel, Terhaard, Chris H.J., Doornaert, Patricia A.H., Philippens, Marielle E.P., Raaijmakers, Cornelis P.J., Fysica Radiotherapie Research, MS Radiotherapie, Cancer, Klinische Fysica RT, Reinders, Floris C.J., Heijst, Tristan C.F.van, Mases, Joel, Terhaard, Chris H.J., Doornaert, Patricia A.H., Philippens, Marielle E.P., and Raaijmakers, Cornelis P.J.

Published
2021

49. National Protocol for Model-Based Selection for Proton Therapy in Head and Neck Cancer

Author

MS Radiotherapie, Cancer, Epi Methoden Team 4, Circulatory Health, JC onderzoeksprogramma Methodologie, Epi Methoden Team 1, Langendijk, Johannes A, Hoebers, Frank J P, de Jong, Martin A, Doornaert, Patricia, Terhaard, Chris H J, Steenbakkers, Roel J H M, Hamming-Vrieze, Olga, van de Kamer, Jeroen B, Verbakel, Wilko F A R, Keskin-Cambay, Fatma, Reitsma, Johannes B, van der Schaaf, Arjen, Boersma, Liesbeth J, Schuit, Ewoud, MS Radiotherapie, Cancer, Epi Methoden Team 4, Circulatory Health, JC onderzoeksprogramma Methodologie, Epi Methoden Team 1, Langendijk, Johannes A, Hoebers, Frank J P, de Jong, Martin A, Doornaert, Patricia, Terhaard, Chris H J, Steenbakkers, Roel J H M, Hamming-Vrieze, Olga, van de Kamer, Jeroen B, Verbakel, Wilko F A R, Keskin-Cambay, Fatma, Reitsma, Johannes B, van der Schaaf, Arjen, Boersma, Liesbeth J, and Schuit, Ewoud

Published
2021

50. Cost-utility and cost-effectiveness of a guided self-help head and neck exercise program for patients treated with total laryngectomy: Results of a multi-center randomized controlled trial

Author

Divisie Beeld & Oncologie, MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiotherapie, Jansen, Femke, Coupé, Veerle M.H., Eerenstein, Simone E.J., Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, Leemans, C. René, Verdonck-de Leeuw, Irma M., Divisie Beeld & Oncologie, MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiotherapie, Jansen, Femke, Coupé, Veerle M.H., Eerenstein, Simone E.J., Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Published
2021

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