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454 results on '"Di Nisio, Marcello"'

1. Risk assessment tools for bleeding in patients with unprovoked venous thromboembolism: an analysis of the PLATO-VTE study

Author

Guman, Noori A.M., Becking, Anne-Marie L., Weijers, Suzanne S., Kraaijpoel, Noémie, Mulder, Frits I., Carrier, Marc, Jara-Palomares, Luis, Di Nisio, Marcello, Ageno, Walter, Beyer-Westendorf, Jan, Klok, Frederikus A., Vanassche, Thomas, Otten, Johannes M.M.B., Cosmi, Benilde, Peters, Mike J.L., Wolde, Marije ten, Delluc, Aurélien, Sanchez-Lopez, Veronica, Porreca, Ettore, Bossuyt, Patrick M.M., Gerdes, Victor E.A., Büller, Harry R., van Es, Nick, and Kamphuisen, Pieter W.

Published
2024
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3. Unmet needs and barriers in venous thromboembolism education and awareness among people living with cancer: a global survey

Author

Potere, Nicola, Mahé, Isabelle, Angchaisuksiri, Pantep, Cesarman-Maus, Gabriela, Tan, Chee Wee, Rashid, Anila, AlGahtani, Farjah H., Imbalzano, Egidio, van Es, Nick, Leader, Avi, Olayemi, Edeghonghon, Porreca, Ettore, Ní Áinle, Fionnuala, Okoye, Helen C., Candeloro, Matteo, Mayeur, Didier, Valerio, Luca, Clark, R. Cary, Castellucci, Lana A., Barco, Stefano, and Di Nisio, Marcello

Published
2024
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6. Clinical course and treatment of incidentally detected splanchnic vein thrombosis: an individual patient data meta-analysis

Author

Candeloro, Matteo, Valeriani, Emanuele, Monreal, Manuel, Ageno, Walter, Riva, Nicoletta, Schulman, Sam, Bang, Soo-Mee, Mellado, Meritxell, Díaz-Peromingo, José Antonio, Moisés, Jorge, Díaz-Brasero, Ana María, Garcia-Pagan, Juan-Carlos, Perez-Campuzano, Valeria, Senzolo, Marco, De Gottardi, Andrea, and Di Nisio, Marcello

Published
2023
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8. Venous thromboembolism secondary to hospitalization for COVID-19: patient management and long-term outcomes

Author

Ageno, Walter, Girardi, Laura, Sterpone, Paola, Cosmi, Benilde, Bucherini, Eugenio, Chistolini, Antonio, Serrao, Alessandra, Di Nisio, Marcello, Potere, Nicola, Porreca, Ettore, Fregoni, Vittorio, Grandone, Elvira, Colaizzo, Donatella, Insana, Antonio, Lerede, Teresa, Falanga, Anna, Martinelli, Ida, Bucciarelli, Paolo, Abbattista, Maria, Martini, Giuliana, Masciocco, Lucilla, Mastroiacovo, Daniela, Pancani, Roberta, Carrozzi, Laura, Paparo, Carmelo, Pedrini, Simona, Pieralli, Filippo, Milia, Alessandro, Pignatelli, Pasquale, Menichelli, Danilo, Pizzini, Attilia Maria, Silingardi, Mauro, Podda, GianMarco, Birocchi, Simone, Poli, Daniela, Crudele, Felice, Lotti, Elena, Marcucci, Rossella, Preti, Paola Stefania, Sarti, Luca, Trovati, Alice, Caronna, Antonella, Famiglietti, Elena, Lami, Francesca, Nicolini, Alberto, Scaglioni, Federica, Testa, Sophie, Paoletti, Oriana, Tosetto, Alberto, Toma, Andrea, Villalta, Sabina, Visonà, Adriana, Zalunardo, Beniamino, Panzavolta, Chiara, Antonucci, Emilia, Podda, Gian Marco, and Palareti, Gualtiero

Published
2023
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10. Platelet RNA sequencing for cancer screening in patients with unprovoked venous thromboembolism: a prospective cohort study

Author

Mulder, Frits I., Kraaijpoel, Noémie, Carrier, Marc, Guman, Noori A., Jara-Palomares, Luis, Di Nisio, Marcello, Ageno, Walter, Beyer-Westendorf, Jan, Klok, Frederikus A., Vanassche, Thomas, Otten, Hans-Martin B., Cosmi, Benilde, Wolde, Marije ten, In ‘t Veld, Sjors G.J. G., Post, Edward, Ramaker, Jip, Zwaan, Kenn, Peters, Mike, Delluc, Aurélien, Kamphuisen, Pieter W., Sanchez-Lopez, Veronica, Porreca, Ettore, Bossuyt, Patrick M.M., Büller, Harry R., Wurdinger, Thomas, Best, Myron G., and van Es, Nick

Published
2023
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15. Rivaroxaban for the treatment of noncirrhotic splanchnic vein thrombosis: an interventional prospective cohort study

Author

Ageno, Walter, Beyer Westendorf, Jan, Contino, Laura, Bucherini, Eugenio, Sartori, Maria Teresa, Senzolo, Marco, Grandone, Elvira, Santoro, Rita, Carrier, Marc, Delluc, Aurélien, De Stefano, Valerio, Pomero, Fulvio, Donadini, Marco Paolo, Tosetto, Alberto, Becattini, Cecilia, Martinelli, Ida, Nardo, Barbara, Bertoletti, Laurent, Di Nisio, Marcello, Lazo-Langner, Alejandro, Schenone, Alessandro, and Riva, Nicoletta

Published
2022
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18. Catheter‐related deep vein thrombosis: Where are we at and where are we going? Updates and ongoing unmet clinical needs.

Author

Girardi, Laura, Di Nisio, Marcello, Candeloro, Matteo, Valeriani, Emanuele, and Ageno, Walter

Subjects
*VENOUS thrombosis, *CENTRAL venous catheters, *IMPLANTABLE catheters, *THROMBOEMBOLISM, *DRUG development
Abstract

Background Aims Methods Content Conclusions Catheter‐related thrombosis (CRT) is one of the major complications affecting patients with indwelling venous catheters, usually involving the upper extremity deep venous system. This condition can lead to potentially life‐threatening complications such as pulmonary embolism and sepsis. The risk of developing CRT varies depending on type of catheters and patient characteristics. Despite advances in materials and technologies, the actual incidence of CRT is still considerable. Available evidence on CRT management remains controversial, and clinical guidelines base their recommendations on data from non‐catheter related upper extremity or lower extremity deep venous thromboses.This narrative review aims to describe the epidemiology of CRT, to review the available evidence on its management and to highlight the current unmet needs.No formal search strategy was applied for the revision of the literature. The main sources of information used were Medline and guidelines from international societies.The management of CRT requires a careful balance between the risk of thrombus progression, recurrent events, and systemic embolization and the increased bleeding risk in often fragile patients. Open issues include the optimal management of the catheter and the type and duration of anticoagulant therapy. Direct oral anticoagulants are increasingly prescribed, representing an important alternative to the standard of care low molecular weight heparins in selected cases. The development of new anticoagulant drugs such as factors XI and XII inhibitors may offer further advantages in this context.The management of CRT is still challenging with constant need for updated evidence to support tailored approaches. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Epidemiology of deep vein thrombosis.

Author

Wolf, Simon, Barco, Stefano, Di Nisio, Marcello, Mahan, Charles E., Christodoulou, Konstantinos C., ter Haar, Sophie, Konstantinides, Stavros, Kucher, Nils, Klok, Frederikus A., Cannegieter, Suzanne C., and Valerio, Luca

Published
2024
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20. Treatment of Superficial Vein Thrombosis: Recent Advances, Unmet Needs and Future Directions.

Author

Di Nisio, Marcello, Camporese, Giuseppe, Di Micco, Pierpaolo, Martini, Romeo, Ageno, Walter, and Prandoni, Paolo

Subjects
ANTICOAGULANTS, ANTI-inflammatory agents, LOW-molecular-weight heparin, ARM, PATIENT safety, VENOUS thrombosis, TREATMENT effectiveness, TREATMENT duration, ENOXAPARIN, NEEDS assessment, RIVAROXABAN
Abstract

Once considered relatively benign, superficial vein thrombosis (SVT) of the lower limbs is linked to deep vein thrombosis (DVT) or pulmonary embolism (PE) in up to one fourth of cases. Treatment goals include alleviating local symptoms and preventing SVT from recurring or extending into DVT or PE. Fondaparinux 2.5 mg once daily for 45 days is the treatment of choice for most patients with SVT. Potential alternatives include intermediate-dose low-molecular-weight heparin or the direct oral factor Xa inhibitor rivaroxaban, however, these require further evidence. Despite these treatment options, significant gaps remain, including the role of systemic or topical anti-inflammatory agents alone or combined with anticoagulants, and the optimal duration of anticoagulation for patients at varying risk levels. Additionally, the efficacy and safety of factor Xa inhibitors other than rivaroxaban, management of upper extremity SVT, and optimal treatment for SVT near the sapheno-femoral or sapheno-popliteal junctions are not well understood. This narrative review aims to summarize current evidence on anticoagulant treatment for SVT, highlight key unmet needs in current approaches, and discuss how ongoing studies may address these gaps. [ABSTRACT FROM AUTHOR]

Published
2024
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23. The prognostic value of respiratory symptoms and performance status in ambulatory cancer patients and unsuspected pulmonary embolism; analysis of an international, prospective, observational cohort study

Author

Maraveyas, Anthony, Kraaijpoel, Noémie, Bozas, George, Huang, Chao, Mahé, Isabelle, Bertoletti, Laurent, Bartels‐Rutten, Annemarieke, Beyer‐Westendorf, Jan, Constans, Joel, Iosub, Diana, Couturaud, Francis, Muñoz, Andres J., Biosca, Mercedes, Lerede, Teresa, van Es, Nick, and Di Nisio, Marcello

Published
2021
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24. Recurrent bleeding and thrombotic events after resumption of oral anticoagulants following gastrointestinal bleeding: Communication from the ISTH SSC Subcommittee on Control of Anticoagulation

Author

Candeloro, Matteo, van Es, Nick, Cantor, Nathan, Schulman, Sam, Carrier, Marc, Ageno, Walter, Aibar, Jesus, Donadini, Marco Paolo, Bavalia, Roisin, Arsenault, Marie‐Pier, Coppens, Michiel, Ferrante, Noemi, D’Addezio, Andrea, Sormani, Stefano, Porreca, Ettore, and Di Nisio, Marcello

Published
2021
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25. Clinical history of cancer‐associated splanchnic vein thrombosis

Author

Valeriani, Emanuele, Di Nisio, Marcello, Riva, Nicoletta, Caiano, Lucia Maria, Porreca, Ettore, Bang, Soo‐Mee, Beyer‐Westendorf, Jan, Sartori, Maria Teresa, Barillari, Giovanni, Santoro, Rita, Kamphuisen, Pieter W., Alatri, Adriano, Malato, Alessandra, Vidili, Gianpaolo, Oh, Doyeun, Schulman, Sam, and Ageno, Walter

Published
2021
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29. Evaluating prophylactic heparin in ambulatory patients with solid tumours: a systematic review and individual participant data meta-analysis

Author

Schünemann, Holger J, Ventresca, Matthew, Crowther, Mark, Briel, Matthias, Zhou, Qi, Noble, Simon, Macbeth, Fergus, Griffiths, Gareth, Garcia, David, Lyman, Gary H, Di Nisio, Marcello, Iorio, Alfonso, Mbuagbaw, Lawrence, Neumann, Ignacio, van Es, Nick, Brouwers, Melissa, Guyatt, Gordon, Streiff, Michael B, Marcucci, Maura, Baldeh, Tejan, Florez, Ivan D, Alma, Ozlem Gurunlu, Solh, Ziad, Bossuyt, Patrick M, Kahale, Lara A, Ageno, Walter, Bozas, George, Büller, Harry R, Lebeau, Bernard, Lecumberri, Ramon, Loprinzi, Charles, McBane, Robert, Sideras, Kostandinos, Maraveyas, Anthony, Pelzer, Uwe, Perry, James, Klerk, Clara, Agnelli, Giancarlo, and Akl, Elie A

Published
2020
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30. The Khorana score for prediction of venous thromboembolism in cancer patients: An individual patient data meta‐analysis

Author

van Es, Nick, Ventresca, Matthew, Di Nisio, Marcello, Zhou, Qi, Noble, Simon, Crowther, Mark, Briel, Matthias, Garcia, David, Lyman, Gary H., Macbeth, Fergus, Griffiths, Gareth, Iorio, Alfonso, Mbuagbaw, Lawrence, Neumann, Ignacio, Brozek, Jan, Guyatt, Gordon, Streiff, Michael B., Baldeh, Tejan, Florez, Ivan D., Gurunlu Alma, Ozlem, Agnelli, Giancarlo, Ageno, Walter, Marcucci, Maura, Bozas, George, Zulian, Gilbert, Maraveyas, Anthony, Lebeau, Bernard, Lecumberri, Ramon, Sideras, Kostandinos, Loprinzi, Charles, McBane, Robert, Pelzer, Uwe, Riess, Hanno, Solh, Ziad, Perry, James, Kahale, Lara A., Bossuyt, Patrick M., Klerk, Clara, Büller, Harry R., Akl, Elie A., and Schünemann, Holger J.

Published
2020
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38. Factor XI inhibitors: a new option for the prevention and treatment of cancer-associated thrombosis.

Author

Di Nisio, Marcello, Candeloro, Matteo, Potere, Nicola, Porreca, Ettore, and Weitz, Jeffrey I.

Subjects
*LOW-molecular-weight heparin, *SUBCUTANEOUS injections, *THROMBOEMBOLISM, *DRUG interactions, *GASTROINTESTINAL cancer, *GASTROINTESTINAL hemorrhage
Abstract

Venous thromboembolism (VTE) is a relatively common complication in cancer patients with potentially dire consequences. Anticoagulants are the mainstay of treatment of cancer-associated VTE. The anticoagulants most often used are low-molecular-weight heparin (LMWH) and direct oral factor (F) Xa inhibitors, which include apixaban, edoxaban, and rivaroxaban. Most guidelines recommend primary VTE prophylaxis with LMWH, apixaban, or rivaroxaban after abdominal or pelvic cancer surgery, or in high-risk ambulatory cancer patients. Both oral FXa inhibitors and LMWH have limitations. LMWH requires daily subcutaneous injections, and because of its renal clearance, its use may be problematic in patients with severe kidney disease. The risk of bleeding with oral FXa inhibitors may be higher than with LMWH in patients with intraluminal gastrointestinal or genitourinary cancers. Other problems with oral FXa inhibitors include potential drug-drug interactions and dosing issues in patients with thrombocytopenia or severe kidney or liver disease. Therefore, there remains a need for convenient and safer anticoagulants for VTE treatment in cancer patients. FXI has emerged as a potentially safer target for anticoagulants than FXa because FXI is essential for thrombosis, but mostly dispensable for hemostasis. This review summarizes the currently available therapeutic options for cancer-associated VTE, highlights knowledge gaps, and discusses the potential of FXI inhibitors to address key unmet clinical needs in this vulnerable patient population. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Awareness of venous thromboembolism among patients with cancer: Preliminary findings from a global initiative for World Thrombosis Day

Author

Potere, Nicola, primary, Barco, Stefano, additional, Mahé, Isabelle, additional, Cesarman‐Maus, Gabriela, additional, Angchaisuksiri, Pantep, additional, Leader, Avi, additional, Okoye, Helen C., additional, Olayemi, Edeghonghon, additional, Ay, Cihan, additional, Carrier, Marc, additional, Connors, Jean Marie, additional, Farmakis, Ioannis T., additional, Fumagalli, Riccardo M., additional, Jing, Zhi‐Cheng, additional, Lee, Lai Heng, additional, McLintock, Claire, additional, Ní Ainle, Fionnuala, additional, Giannakoulas, George, additional, Goto, Shinya, additional, Guillermo Esposito, Maria Cecilia, additional, Jara‐Palomares, Luis, additional, Szlaszynska, Marta, additional, Tan, Chee Wee, additional, Van Es, Nick, additional, Wang, Tzu‐Fei, additional, Hunt, Beverley J., additional, and Di Nisio, Marcello, additional

Published
2022
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45. Frailty phenotype as a predictor of bleeding and mortality in ambulatory patients receiving direct oral anticoagulants

Author

Candeloro, Matteo, primary, Di Nisio, Marcello, additional, Potere, Nicola, additional, Di Pizio, Lorenzo, additional, Secinaro, Enzo, additional, De Flaviis, Claudia, additional, Federici, Camilla, additional, Guglielmi, Maria Domenica, additional, Pardi, Silvana, additional, Schulman, Sam, additional, and Porreca, Ettore, additional

Published
2022
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47. Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism

Author

Raskob, Gary E., van Es, Nick, Verhamme, Peter, Carrier, Marc, Di Nisio, Marcello, Garcia, David, Grosso, Michael A., Kakkar, Ajay K., Kovacs, Michael J., Mercuri, Michele F., Meyer, Guy, Segers, Annelise, Shi, Minggao, Wang, Tzu-Fei, Yeo, Erik, Zhang, George, Zwicker, Jeffrey I., Weitz, Jeffrey I., and Büller, Harry R.

Published
2018
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49. Common Practice in the Treatment of Superficial Vein Thrombosis Involving the Sapheno-Femoral Junction: Results from a National Survey of the Italian Society of Angiology and Vascular Medicine (SIAPAV).

Author

Camporese, Giuseppe, Di Micco, Pierpaolo, Di Nisio, Marcello, Ageno, Walter, Martini, Romeo Costanzo, and Prandoni, Paolo

Subjects
VASCULAR medicine, VENOUS thrombosis, SAPHENOUS vein, THROMBOSIS, VEINS
Abstract

Background and Objectives: Prophylactic doses of low-molecular-weight heparins or fondaparinux showed their efficacy and safety for treatment of all superficial vein thrombosis (SVT) of the lower limbs, yet not for those extended to the last 3 cm of the great saphenous vein, close to the sapheno-femoral junction, or considered as a deep-vein thrombosis. Some experts suggest that these patients should be managed with full anticoagulant doses but evidence to support this recommendation is lacking, suggesting the need for a properly designed trial. Materials and Methods: Before starting a new trial, the Italian Society of Angiology and Vascular Medicine (SIAPAV) decided to verify the common therapeutic approaches for patients with an SVT in Italian vascular centers based on a hypothetical significant variation in each daily clinical practice. A standardized questionnaire of 10 questions was administered to all SIAPAV affiliates by means of the official Society website. Results: From 1 December 2022 to 20 January 2023 a total of 191 members (31.8%) answered the questionnaire, showing a detailed and a substantial heterogeneity in the therapeutic approach to SVT patients among experienced vascular physicians and angiologists. Detailed results are reported in the relative section. Conclusions: The therapeutic approach of SVT extended to the iuxta-femoral segment of the great saphenous vein is still a matter of debate, and data to support therapeutic strategies are lacking. The wide heterogeneity in the management of SVT patients, including those with more extended thrombosis, confirmed that a randomized controlled clinical trial investigating the efficacy and the safety of a tailored therapeutic regimen in this particular subgroup of patients is strongly warranted. [ABSTRACT FROM AUTHOR]

Published
2023
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