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198 results on '"Di Ianni, Mauro"'

1. A pro-inflammatory environment in bone marrow of Treg transplanted patients matches with graft-versus-leukemia effect

Author

Guardalupi, Francesco, Sorrentino, Carlo, Corradi, Giulia, Giancola, Raffaella, Baldoni, Stefano, Ulbar, Francesca, Fabi, Bianca, Andres Ejarque, Rosa, Timms, Jessica, Restuccia, Francesco, Santarone, Stella, Accorsi, Patrizia, Sportoletti, Paolo, De Falco, Filomena, Rosati, Emanuela, Carotti, Alessandra, Falzetti, Franca, Velardi, Andrea, Martelli, Massimo Fabrizio, Kordasti, Shahram, Pierini, Antonio, Ruggeri, Loredana, and Di Ianni, Mauro

Published
2023
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2. Prednisone vs high-dose dexamethasone in newly diagnosed adult primary immune thrombocytopenia: a randomized trial

Author

Mazzucconi, Maria Gabriella, Rodeghiero, Francesco, Avvisati, Giuseppe, De Stefano, Valerio, Gugliotta, Luigi, Ruggeri, Marco, Vianelli, Nicola, Fazi, Paola, Paoloni, Francesca, Sargentini, Valeria, Baldacci, Erminia, Ferretti, Antonietta, Martino, Bruno, Vincelli, Iolanda Donatella, Carli, Giuseppe, Fortuna, Stefania, Di Ianni, Mauro, Ranalli, Paola, Palandri, Francesca, Polverelli, Nicola, Lugli, Elisabetta, Rivolti, Elena, Patriarca, Andrea, Rago, Angela, D’Adda, Mariella, Gentile, Massimo, Siragusa, Sergio, Sibilla, Silvia, Carella, Angelo Michele, Rossi, Elena, Battistini, Roberta, Zaja, Francesco, Bocchia, Monica, Di Renzo, Nicola, Musto, Pellegrino, Crugnola, Monica, Giuffrida, Anna Chiara, Krampera, Mauro, Tafuri, Agostino, and Santoro, Cristina

Published
2024
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3. Donor lymphocyte infusions after haploidentical stem cell transplantation with PTCY: A study on behalf of the EBMT cellular therapy & immunobiology working party

Author

Santoro, Nicole, Mooyaart, Jarl E., Devillier, Raynier, Koc, Yener, Vydra, Jan, Castagna, Luca, Gülbas, Zafer, Martin, José Diez, Araujo, Mercedes Colorado, Kulagin, Alexander, Arat, Mutlu, Arroyo, Concepcion Herrera, Martelli, Maria Paola, Di Ianni, Mauro, Hoogenboom, Jorinde D., de Wreede, Liesbeth C., Ruggeri, Annalisa, and Chabannon, Christian

Published
2023
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6. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

Author

Fuchs, Anke, Gliwiński, Mateusz, Grageda, Nathali, Spiering, Rachel, Abbas, Abul K, Appel, Silke, Bacchetta, Rosa, Battaglia, Manuela, Berglund, David, Blazar, Bruce, Bluestone, Jeffrey A, Bornhäuser, Martin, Brinke, Anja ten, Brusko, Todd M, Cools, Nathalie, Cuturi, Maria Cristina, Geissler, Edward, Giannoukakis, Nick, Gołab, Karolina, Hafler, David A, van Ham, S Marieke, Hester, Joanna, Hippen, Keli, Di Ianni, Mauro, Ilic, Natasa, Isaacs, John, Issa, Fadi, Iwaszkiewicz-Grześ, Dorota, Jaeckel, Elmar, Joosten, Irma, Klatzmann, David, Koenen, Hans, van Kooten, Cees, Korsgren, Olle, Kretschmer, Karsten, Levings, Megan, Marek-Trzonkowska, Natalia Maria, Martinez-Llordella, Marc, Miljkovic, Djordje, Mills, Kingston HG, Miranda, Joana P, Piccirillo, Ciriaco A, Putnam, Amy L, Ritter, Thomas, Roncarolo, Maria Grazia, Sakaguchi, Shimon, Sánchez-Ramón, Silvia, Sawitzki, Birgit, Sofronic-Milosavljevic, Ljiljana, Sykes, Megan, Tang, Qizhi, Vives-Pi, Marta, Waldmann, Herman, Witkowski, Piotr, Wood, Kathryn J, Gregori, Silvia, Hilkens, Catharien MU, Lombardi, Giovanna, Lord, Phillip, Martinez-Caceres, Eva M, and Trzonkowski, Piotr

Subjects
Vaccine Related, Autoimmune Disease, Inflammatory and immune system, minimum information model, T regulatory cells, immunotherapy, good manufacturing practice, cell therapy, immune tolerance, Immunology, Medical Microbiology
Abstract

Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While the number of clinical trials testing Tregs is already substantial, it seems to be crucial to provide some standardized characteristics of Treg products in order to minimize the problem. We have previously developed reporting guidelines called minimum information about tolerogenic antigen-presenting cells, which allows the comparison between different preparations of tolerance-inducing antigen-presenting cells. Having this experience, here we describe another minimum information about Tregs (MITREG). It is important to note that MITREG does not dictate how investigators should generate or characterize Tregs, but it does require investigators to report their Treg data in a consistent and transparent manner. We hope this will, therefore, be a useful tool facilitating standardized reporting on the manufacturing of Tregs, either for research purposes or for clinical application. This way MITREG might also be an important step toward more standardized and reproducible testing of the Tregs preparations in clinical applications.

Published
2018

8. Exploring the Immunomodulatory Potential of Pancreatic Cancer-Derived Extracellular Vesicles through Proteomic and Functional Analyses

Author

Piro, Anna, primary, Cufaro, Maria Concetta, additional, Lanuti, Paola, additional, Brocco, Davide, additional, De Lellis, Laura, additional, Florio, Rosalba, additional, Pilato, Serena, additional, Pagotto, Sara, additional, De Fabritiis, Simone, additional, Vespa, Simone, additional, Catitti, Giulia, additional, Verginelli, Fabio, additional, Simeone, Pasquale, additional, Pieragostino, Damiana, additional, Del Boccio, Piero, additional, Fontana, Antonella, additional, Grassadonia, Antonino, additional, Di Ianni, Mauro, additional, Cama, Alessandro, additional, and Veschi, Serena, additional

Published
2024
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10. Correction: Donor lymphocyte infusions after haploidentical stem cell transplantation with PTCY: A study on behalf of the EBMT cellular therapy & immunobiology working party

Author

Santoro, Nicole, Mooyaart, Jarl E., Devillier, Raynier, Koc, Yener, Vydra, Jan, Castagna, Luca, Gülbas, Zafer, Martin, José Diez, Araujo, Mercedes Colorado, Kulagin, Alexander, Arat, Mutlu, Arroyo, Concepcion Herrera, Martelli, Maria Paola, Di Ianni, Mauro, Hoogenboom, Jorinde D., de Wreede, Liesbeth C., Ruggeri, Annalisa, and Chabannon, Christian

Published
2023
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11. Haploidentical age-adapted myeloablative transplant and regulatory and effector T cells for acute myeloid leukemia

Author

Pierini, Antonio, Ruggeri, Loredana, Carotti, Alessandra, Falzetti, Franca, Saldi, Simonetta, Terenzi, Adelmo, Zucchetti, Claudio, Ingrosso, Gianluca, Zei, Tiziana, Iacucci Ostini, Roberta, Piccinelli, Sara, Bonato, Samanta, Tricarico, Sara, Mancusi, Antonella, Ciardelli, Sara, Limongello, Roberto, Merluzzi, Mara, Di Ianni, Mauro, Tognellini, Rita, Minelli, Olivia, Mecucci, Cristina, Martelli, Maria Paola, Falini, Brunangelo, Martelli, Massimo Fabrizio, Aristei, Cynthia, and Velardi, Andrea

Published
2021
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12. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.

Author

Fuchs, Anke, Gliwiński, Mateusz, Grageda, Nathali, Spiering, Rachel, Abbas, Abul K, Appel, Silke, Bacchetta, Rosa, Battaglia, Manuela, Berglund, David, Blazar, Bruce, Bluestone, Jeffrey A, Bornhäuser, Martin, Ten Brinke, Anja, Brusko, Todd M, Cools, Nathalie, Cuturi, Maria Cristina, Geissler, Edward, Giannoukakis, Nick, Gołab, Karolina, Hafler, David A, van Ham, S Marieke, Hester, Joanna, Hippen, Keli, Di Ianni, Mauro, Ilic, Natasa, Isaacs, John, Issa, Fadi, Iwaszkiewicz-Grześ, Dorota, Jaeckel, Elmar, Joosten, Irma, Klatzmann, David, Koenen, Hans, van Kooten, Cees, Korsgren, Olle, Kretschmer, Karsten, Levings, Megan, Marek-Trzonkowska, Natalia Maria, Martinez-Llordella, Marc, Miljkovic, Djordje, Mills, Kingston HG, Miranda, Joana P, Piccirillo, Ciriaco A, Putnam, Amy L, Ritter, Thomas, Roncarolo, Maria Grazia, Sakaguchi, Shimon, Sánchez-Ramón, Silvia, Sawitzki, Birgit, Sofronic-Milosavljevic, Ljiljana, Sykes, Megan, Tang, Qizhi, Vives-Pi, Marta, Waldmann, Herman, Witkowski, Piotr, Wood, Kathryn J, Gregori, Silvia, Hilkens, Catharien MU, Lombardi, Giovanna, Lord, Phillip, Martinez-Caceres, Eva M, and Trzonkowski, Piotr

Subjects
T regulatory cells, cell therapy, good manufacturing practice, immune tolerance, immunotherapy, minimum information model, Autoimmune Disease, Vaccine Related, Inflammatory and Immune System, Immunology, Medical Microbiology
Abstract

Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While the number of clinical trials testing Tregs is already substantial, it seems to be crucial to provide some standardized characteristics of Treg products in order to minimize the problem. We have previously developed reporting guidelines called minimum information about tolerogenic antigen-presenting cells, which allows the comparison between different preparations of tolerance-inducing antigen-presenting cells. Having this experience, here we describe another minimum information about Tregs (MITREG). It is important to note that MITREG does not dictate how investigators should generate or characterize Tregs, but it does require investigators to report their Treg data in a consistent and transparent manner. We hope this will, therefore, be a useful tool facilitating standardized reporting on the manufacturing of Tregs, either for research purposes or for clinical application. This way MITREG might also be an important step toward more standardized and reproducible testing of the Tregs preparations in clinical applications.

Published
2017

13. NOTCH1 inhibition prevents GvHD and maintains GvL effect in murine models

Author

Baldoni, Stefano, Ruggeri, Loredana, Del Papa, Beatrice, Sorcini, Daniele, Guardalupi, Francesco, Ulbar, Francesca, Marra, Andrea, Dorillo, Erica, Stella, Arianna, Giancola, Raffaella, Fabi, Bianca, Sola, Rosaria, Ciardelli, Sara, De Falco, Filomena, Rompietti, Chiara, Adamo, Francesco Maria, Rosati, Emanuela, Pierini, Antonio, Sorrentino, Carlo, Sportoletti, Paolo, and Di Ianni, Mauro

Published
2021
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14. Long‐term pharmacodynamic and clinical effects of twice‐ versus once‐daily low‐dose aspirin in essential thrombocythemia: The ARES trial.

Author

Rocca, Bianca, Tosetto, Alberto, Petrucci, Giovanna, Rossi, Elena, Betti, Silvia, Soldati, Denise, Iurlo, Alessandra, Cattaneo, Daniele, Bucelli, Cristina, Dragani, Alfredo, Di Ianni, Mauro, Ranalli, Paola, Palandri, Francesca, Vianelli, Nicola, Beggiato, Eloise, Lanzarone, Giuseppe, Ruggeri, Marco, Carli, Giuseppe, Elli, Elena Maria, and Renso, Rossella

Published
2024
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15. Myelofibrosis and allogeneic transplantation: critical points and challenges.

Author

Ranalli, Paola, Natale, Annalisa, Guardalupi, Francesco, Santarone, Stella, Cantò, Chiara, La Barba, Gaetano, and Di Ianni, Mauro

Subjects
MYELOFIBROSIS, HEMATOPOIETIC stem cell transplantation, PROGNOSIS, BONE marrow transplantation
Abstract

New available drugs allow better control of systemic symptoms associated with myelofibrosis (MF) and splenomegaly but they do not modify the natural history of progressive and poor prognosis disease. Thus, hematopoietic stem cell transplantation (HSCT) is still considered the only available curative treatment for patients with MF. Despite the increasing number of procedures worldwide in recent years, HSCT for MF patients remains challenging. An increasingly complex network of the patient, disease, and transplant-related factors should be considered to understand the need for and the benefits of the procedure. Unfortunately, prospective trials are often lacking in this setting, making an evidence-based decision process particularly arduous. In the present review, we will analyze the main controversial points of allogeneic transplantation in MF, that is, the development of more sophisticated models for the identification of eligible patients; the need for tools offering a more precise definition of expected outcomes combining comorbidity assessment and factors related to the procedure; the decision-making process about the best transplantation time; the evaluation of the most appropriate platform for curative treatment; the impact of splenomegaly; and splenectomy on outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation

Author

Di Ianni, Mauro, primary, Liberatore, Carmine, additional, Santoro, Nicole, additional, Ranalli, Paola, additional, Guardalupi, Francesco, additional, Corradi, Giulia, additional, Villanova, Ida, additional, Di Francesco, Barbara, additional, Lattanzio, Stefano, additional, Passeri, Cecilia, additional, Lanuti, Paola, additional, and Accorsi, Patrizia, additional

Published
2023
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19. Case Report: Invasive fungal infection after anti-CD19 CAR-T cell therapy. Implication for antifungal prophylaxis

Author

Pennese, Elsa, primary, Salutari, Prassede, additional, Carriero, Luigi, additional, Restuccia, Francesco, additional, De Filippis, Antonio Fabio, additional, De Luca, Giulia, additional, Giancola, Raffaella, additional, Guardalupi, Francesco, additional, Corradi, Giulia, additional, Fabi, Bianca, additional, Baldoni, Stefano, additional, and Di Ianni, Mauro, additional

Published
2023
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20. Daratumumab‐based induction and autologous transplantation in concomitant multiple myeloma and chronic myeloid leukemia

Author

Liberatore, Carmine, primary, Fioritoni, Francesca, additional, Natale, Annalisa, additional, Montanaro, Guido, additional, La Barba, Gaetano, additional, Passeri, Cecilia, additional, Iuliani, Ornella, additional, Fabi, Bianca, additional, Baldoni, Stefano, additional, Fantasia, Donatella, additional, Calabrese, Giuseppe, additional, Accorsi, Patrizia, additional, Santarone, Stella, additional, Pulini, Stefano, additional, and Di Ianni, Mauro, additional

Published
2023
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21. Therapeutic Targeting Potential of Novel Silver Nanoparticles Coated with Anti-CD20 Antibody against Chronic Lymphocytic Leukemia

Author

Adamo, Francesco Maria, primary, Silva Barcelos, Estevao Carlos, additional, De Falco, Filomena, additional, Dorillo, Erica, additional, Rompietti, Chiara, additional, Sorcini, Daniele, additional, Stella, Arianna, additional, Del Papa, Beatrice, additional, Baldoni, Stefano, additional, Esposito, Angela, additional, Geraci, Clelia, additional, Arcaleni, Roberta, additional, Pennetta, Chiara, additional, Ragonese, Francesco, additional, Moretti, Lorenzo, additional, Mameli, Mariagrazia, additional, Di Ianni, Mauro, additional, Rosati, Emanuela, additional, Fioretti, Bernard, additional, and Sportoletti, Paolo, additional

Published
2023
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22. Higher cyclophosphamide dose grants optimal stem cell collection after daratumumab-based induction in multiple myeloma

Author

Liberatore, Carmine, primary, Perini, Tommaso, additional, Passeri, Cecilia, additional, Ferla, Valeria, additional, Fioritoni, Francesca, additional, Girlando, Virginia, additional, Iuliani, Ornella, additional, Orsini, Alessia, additional, Montanaro, Guido, additional, Farina, Francesca, additional, Di Nicola, Alessandro, additional, Nitti, Rosamaria, additional, Pulini, Stefano, additional, Mastaglio, Sara, additional, Santarone, Stella, additional, Coppola, Milena, additional, Marktel, Sarah, additional, Accorsi, Patrizia, additional, Ciceri, Fabio, additional, Marcatti, Magda, additional, and Di Ianni, Mauro, additional

Published
2023
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23. Clinical-Grade–Expanded Regulatory T Cells Prevent Graft-versus-Host Disease While Allowing a Powerful T Cell–Dependent Graft-versus-Leukemia Effect in Murine Models

Author

Del Papa, Beatrice, Ruggeri, Loredana, Urbani, Elena, Baldoni, Stefano, Cecchini, Debora, Zei, Tiziana, Iacucci Ostini, Roberta, Crescenzi, Barbara, Carotti, Alessandra, Pierini, Antonio, Sportoletti, Paolo, Di Bartolomeo, Paolo, Falzetti, Franca, Mecucci, Cristina, Velardi, Andrea, Martelli, Massimo F., and Di Ianni, Mauro

Published
2017
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24. Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation.

Author

Di Ianni, Mauro, Liberatore, Carmine, Santoro, Nicole, Ranalli, Paola, Guardalupi, Francesco, Corradi, Giulia, Villanova, Ida, Di Francesco, Barbara, Lattanzio, Stefano, Passeri, Cecilia, Lanuti, Paola, and Accorsi, Patrizia

Subjects
*REGULATORY T cells, *SUICIDE, *CELLULAR therapy, *GENE therapy, *BRAIN death
Abstract

GvHD still remains, despite the continuous improvement of transplantation platforms, a fearful complication of transplantation from allogeneic donors. Being able to separate GvHD from GvL represents the greatest challenge in the allogeneic transplant setting. This may be possible through continuous improvement of cell therapy techniques. In this review, current cell therapies are taken into consideration, which are based on the use of TCR alpha/beta depletion, CD45RA depletion, T regulatory cell enrichment, NK-cell-based immunotherapies, and suicide gene therapies in order to prevent GvHD and maximally amplify the GvL effect in the setting of haploidentical transplantation. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Figure S10 from Decreased NOTCH1 Activation Correlates with Response to Ibrutinib in Chronic Lymphocytic Leukemia

Author

Del Papa, Beatrice, primary, Baldoni, Stefano, primary, Dorillo, Erica, primary, De Falco, Filomena, primary, Rompietti, Chiara, primary, Cecchini, Debora, primary, Cantelmi, Maria Grazia, primary, Sorcini, Daniele, primary, Nogarotto, Manuel, primary, Adamo, Francesco Maria, primary, Mezzasoma, Federica, primary, Silva Barcelos, Estevão Carlos, primary, Albi, Elisa, primary, Iacucci Ostini, Roberta, primary, Di Tommaso, Ambra, primary, Marra, Andrea, primary, Montanaro, Guido, primary, Martelli, Maria Paola, primary, Falzetti, Franca, primary, Di Ianni, Mauro, primary, Rosati, Emanuela, primary, and Sportoletti, Paolo, primary

Published
2023
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27. CAR-T-Derived Extracellular Vesicles: A Promising Development of CAR-T Anti-Tumor Therapy

Author

Pagotto, Sara, primary, Simeone, Pasquale, additional, Brocco, Davide, additional, Catitti, Giulia, additional, De Bellis, Domenico, additional, Vespa, Simone, additional, Di Pietro, Natalia, additional, Marinelli, Lisa, additional, Di Stefano, Antonio, additional, Veschi, Serena, additional, De Lellis, Laura, additional, Verginelli, Fabio, additional, Kaitsas, Francesco, additional, Iezzi, Manuela, additional, Pandolfi, Assunta, additional, Visone, Rosa, additional, Tinari, Nicola, additional, Caruana, Ignazio, additional, Di Ianni, Mauro, additional, Cama, Alessandro, additional, Lanuti, Paola, additional, and Florio, Rosalba, additional

Published
2023
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29. Correction: Donor lymphocyte infusions after haploidentical stem cell transplantation with PTCY: A study on behalf of the EBMT cellular therapy & immunobiology working party

Author

Santoro, Nicole, primary, Mooyaart, Jarl E., additional, Devillier, Raynier, additional, Koc, Yener, additional, Vydra, Jan, additional, Castagna, Luca, additional, Gülbas, Zafer, additional, Martin, José Diez, additional, Araujo, Mercedes Colorado, additional, Kulagin, Alexander, additional, Arat, Mutlu, additional, Arroyo, Concepcion Herrera, additional, Martelli, Maria Paola, additional, Di Ianni, Mauro, additional, Hoogenboom, Jorinde D., additional, de Wreede, Liesbeth C., additional, Ruggeri, Annalisa, additional, and Chabannon, Christian, additional

Published
2022
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31. Dosing Pattern of Ruxolitinib (RUX) in Patients with Myelofibrosis (MF) in Italy: Results from a Prospective Observational Study (ROMEI)

Author

Breccia, Massimo, primary, Guglielmelli, Paola, additional, Mendicino, Francesco, additional, Malato, Alessandra, additional, Palumbo, Giuseppe A., additional, Selleri, Carmine, additional, Cilloni, Daniela, additional, Mazza, Patrizio, additional, Siragusa, Sergio, additional, Abruzzese, Elisabetta, additional, Martelli, Maurizio, additional, Benevolo, Giulia, additional, Rinaldi, Erminia, additional, Crugnola, Monica, additional, Rupoli, Serena, additional, Pavone, Vincenzo, additional, Bonifacio, Massimiliano, additional, Pane, Fabrizio, additional, Carli, Giuseppe, additional, Langella, Maria, additional, Bruno Ventre, Marta, additional, Elli, Elena Maria, additional, Impera, Stefana, additional, Liberati, Anna Marina, additional, Di Renzo, Nicola, additional, Martino, Bruno, additional, Sportoletti, Paolo, additional, Tiribelli, Mario, additional, Binotto, Gianni, additional, Annunziata, Mario, additional, Di Ianni, Mauro, additional, La Nasa, Giorgio, additional, Falcone, Antonietta Pia, additional, Leanza, Rossana, additional, Volpe, Antonio, additional, Gherlinzoni, Filippo, additional, De Stefano, Valerio, additional, Vallisa, Daniele, additional, Leonetti Crescenzi, Sabrina, additional, Cavazzini, Francesco, additional, Ricco, Alessandra, additional, Barberio, Carmela, additional, Misto, Alessandra, additional, Passamonti, Francesco, additional, and Palandri, Francesca, additional

Published
2022
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32. Donor lymphocyte infusions after haploidentical stem cell transplantation with PTCY: A study on behalf of the EBMT cellular therapy & immunobiology working party

Author

Santoro, Nicole, primary, Mooyaart, Jarl E., additional, Devillier, Raynier, additional, Koc, Yener, additional, Vydra, Jan, additional, Castagna, Luca, additional, Gülbas, Zafer, additional, Martin, José Diez, additional, Araujo, Mercedes Colorado, additional, Kulagin, Alexander, additional, Arat, Mutlu, additional, Arroyo, Concepcion Herrera, additional, Martelli, Maria Paola, additional, Di Ianni, Mauro, additional, Hoogenboom, Jorinde D., additional, de Wreede, Liesbeth C., additional, Ruggeri, Annalisa, additional, and Chabannon, Christian, additional

Published
2022
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33. Comparison between peripheral blood progenitor cell collection on the 4th or 5th day of granulocyte colony-stimulating factor treatment in allogeneic stem cell donors: implications for hematopoietic progenitor cell apheresis guidelines.

Author

Passeri, Cecilia, Iuliani, Ornella, Di Ianni, Mauro, Sorrentino, Carlo, Giancola, Raffaella, Abbruzzese, Luciano, Dallavalle, Franco M., Gattillo, Salvatore, Mariano, Maria T., Martino, Massimo, Ostuni, Angelo, Savignano, Chiara, Santoleri, Luca, Tison, Tiziana, Vacca, Michele, and Accorsi, Patrizia

Published
2023
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35. NK Cells in Chronic Lymphocytic Leukemia and Their Therapeutic Implications

Author

Sportoletti, Paolo, primary, De Falco, Filomena, additional, Del Papa, Beatrice, additional, Baldoni, Stefano, additional, Guarente, Valerio, additional, Marra, Andrea, additional, Dorillo, Erica, additional, Rompietti, Chiara, additional, Adamo, Francesco Maria, additional, Ruggeri, Loredana, additional, Di Ianni, Mauro, additional, and Rosati, Emanuela, additional

Published
2021
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36. Clinical-Grade Expanded Regulatory T Cells Are Enriched with Highly Suppressive Cells Producing IL-10, Granzyme B, and IL-35

Author

Ulbar, Francesca, Villanova, Ida, Giancola, Raffaella, Baldoni, Stefano, Guardalupi, Francesco, Fabi, Bianca, Olioso, Paola, Capone, Anita, Sola, Rosaria, Ciardelli, Sara, Del Papa, Beatrice, Brattelli, Antonello, Ricciardi, Ilda, Taricani, Stefano, Sabbatinelli, Giulia, Iuliani, Ornella, Passeri, Cecilia, Sportoletti, Paolo, Santarone, Stella, Pierini, Antonio, Calabrese, Giuseppe, Falzetti, Franca, Bonfini, Tiziana, Accorsi, Patrizia, Ruggeri, Loredana, Martelli, Massimo Fabrizio, Velardi, Andrea, and Di Ianni, Mauro

Published
2020
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37. NOTCH1 Activation Negatively Impacts on Chronic Lymphocytic Leukemia Outcome and Is Not Correlated to the NOTCH1 and IGHV Mutational Status

Author

Baldoni, Stefano, primary, Del Papa, Beatrice, additional, De Falco, Filomena, additional, Dorillo, Erica, additional, Sorrentino, Carlo, additional, Rompietti, Chiara, additional, Adamo, Francesco Maria, additional, Nogarotto, Manuel, additional, Cecchini, Debora, additional, Mondani, Elena, additional, Silva Barcelos, Estevao Carlos, additional, Moretti, Lorenzo, additional, Mameli, Maria Grazia, additional, Fabi, Bianca, additional, Sorcini, Daniele, additional, Stella, Arianna, additional, Giancola, Raffaella, additional, Guardalupi, Francesco, additional, Ulbar, Francesca, additional, Plebani, Sara, additional, Guarente, Valerio, additional, Rosati, Emanuela, additional, Di Nicola, Marta, additional, Marchioni, Michele, additional, Di Ianni, Mauro, additional, and Sportoletti, Paolo, additional

Published
2021
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38. DONOR Lymphocyte Infusions after Haploidentical STEM Cell Transplantation with Ptcy: A Study on Behalf of the Ctiwp of the EBMT

Author

Santoro, Nicole, primary, Mauff, Katya, additional, Devillier, Raynier, additional, Castagna, Luca, additional, Gülbas, Zafer, additional, Diez-Martin, José Luis, additional, Bermúdez, Arancha, additional, Arroyo, Concepcion Herrera, additional, Deconinck, Eric, additional, Sierra, Jorge, additional, Abecasis, Manuel, additional, Ozdogu, Hakan, additional, Mico, Maria Caterina, additional, Rocha, Vanderson, additional, Guyotat, Denis, additional, Chalandon, Yves, additional, Forcade, Edouard, additional, Martin, Hans, additional, Saccardi, Riccardo, additional, Giebel, Sebastian, additional, Di Ianni, Mauro, additional, Hoogenboom, Jorinde, additional, de Wreede, Liesbeth C, additional, Ruggeri, Annalisa, additional, and Chabannon, Christian, additional

Published
2021
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39. A randomized, double-blind trial of three aspirin regimens to optimize antiplatelet therapy in essential thrombocythemia

Author

Rocca, Bianca, Tosetto, Alberto, Betti, Silvia, Soldati, Denise, Petrucci, Giovanna, Rossi, Elena, Timillero, Andrea, Cavalca, Viviana, Porro, Benedetta, Iurlo, Alessandra, Cattaneo, Daniele, Bucelli, Cristina, Dragani, Alfredo, Di Ianni, Mauro, Ranalli, Paola, Palandri, Francesca, Vianelli, Nicola, Beggiato, Eloise, Lanzarone, Giuseppe, Ruggeri, Marco, Carli, Giuseppe, Elli, Elena Maria, Carpenedo, Monica, Bertozzi, Irene, Paoli, Chiara, Randi, Maria L, Ricco, Alessandra, Specchia, Giorgina, Vannucchi, Alessandro Maria, Rodeghiero, Francesco, Patrono, Carlo, and De Stefano, Valerio

Subjects
Settore MED/15 - MALATTIE DEL SANGUE, essential thrombocythemia, Settore BIO/14 - FARMACOLOGIA
Published
2020

40. Bepridil exhibits anti‐leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia

Author

Baldoni, Stefano, Del Papa, Beatrice, Dorillo, Erica, Aureli, Patrizia, De Falco, Filomena, Rompietti, Chiara, Sorcini, Daniele, Varasano, Emanuela, Cecchini, Debora, Zei, Tiziana, Di Tommaso, Ambra, Rosati, Emanuela, Alexe, Gabriela, Roti, Giovanni, Stegmaier, Kimberly, Di Ianni, Mauro, Falzetti, Franca, and Sportoletti, Paolo

Subjects
Bepridil, Antineoplastic Agents, Apoptosis, Mice, NOTCH1, hemic and lymphatic diseases, Biomarkers, Tumor, Tumor Microenvironment, Animals, Humans, Receptor, Notch1, Cancer Therapy and Prevention, Chemotaxis, Mesenchymal Stem Cells, targeted therapy, Calcium Channel Blockers, Prognosis, Leukemia, Lymphocytic, Chronic, B-Cell, Xenograft Model Antitumor Assays, embryonic structures, Mutation, cardiovascular system, chronic lymphocytic leukemia, sense organs, biological phenomena, cell phenomena, and immunity, Drug Screening Assays, Antitumor
Abstract

Dysregulated NOTCH1 signaling, by either gene mutations or microenvironment interactions, has been increasingly linked to chronic lymphocytic leukemia (CLL). Thus, inhibiting NOTCH1 activity represents a potential therapeutic opportunity for this disease. Using gene expression‐based screening, we identified the calcium channel modulator bepridil as a new NOTCH1 pathway inhibitor. In primary CLL cells, bepridil induced selective apoptosis even in the presence of the protective stroma. Cytotoxic effects of bepridil were independent of NOTCH1 mutation and other prognostic markers. The antitumor efficacy of bepridil was associated with inhibition of NOTCH1 activity through a decrement in trans‐membrane and activated NOTCH1 protein levels with unchanged NOTCH2 protein levels. In a CLL xenotransplant model, bepridil significantly reduced the percentage of leukemic cells infiltrating the spleen via enhanced apoptosis and decreased NOTCH1 activation. In conclusion, we report in vitro and in vivo anti‐leukemic activity of bepridil associated with inhibition of the NOTCH1 pathway in CLL. These data provide a rationale for the clinical development of bepridil as anti‐NOTCH1 targeted therapy for CLL patients., What's new? In search of new inroads against chronic lymphocytic leukemia, these authors turned to the NOTCH1 signalling pathway. Could inhibiting NOTCH1 help treat CLL? To find out, they first identified the calcium channel blocker bepridil as a NOTCH1 inhibitor. Next, they showed that bepredil induced apoptosis in isolated CLL cells, regardless of whether they bore NOTCH1 mutations. In mice bearing CLL cells, bepredil inhibited the proliferation of the tumor cells with no overt signs of toxicity. Thus, it seems advisable to pursue bepredil as a possible candidate for treating CLL.

Published
2018

41. Association of Platelet Thromboxane Inhibition by Low‐Dose Aspirin With Platelet Count and Cytoreductive Therapy in Essential Thrombocythemia.

Author

Tosetto, Alberto, Rocca, Bianca, Petrucci, Giovanna, Betti, Silvia, Soldati, Denise, Rossi, Elena, Timillero, Andrea, Cavalca, Viviana, Porro, Benedetta, Iurlo, Alessandra, Cattaneo, Daniele, Bucelli, Cristina, Dragani, Alfredo, Di Ianni, Mauro, Ranalli, Paola, Palandri, Francesca, Vianelli, Nicola, Beggiato, Eloise, Lanzarone, Giuseppe, and Ruggeri, Marco

Subjects
ASPIRIN, BLOOD platelets, THROMBOCYTOSIS, MYELOPROLIFERATIVE neoplasms, GENE frequency, BLOOD platelet aggregation, PLATELET count, OLDER patients
Abstract

Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by enhanced platelet production and thrombotic complications. The inhibition of platelet cyclooxygenase (COX) activity by the standard once‐daily aspirin is mostly incomplete due to accelerated thrombopoiesis. The phase II Aspirin Regimens in EsSential thrombocythemia (ARES) trial has recently compared the efficacy of once‐ vs. twice‐ or three‐times daily low‐dose aspirin in inhibiting platelet thromboxane (TX) A2 production, as reflected by serum (s) TXB2 measurements. The present substudy characterized the determinants of the highly variable response to the standard aspirin 100 mg once‐daily regimen in fully compliant patients with ET and the effects of the experimental dosing regimens on response variability. By multivariable analysis, the platelet count (directly) and cytoreductive treatment (inversely) were significantly associated with sTXB2 values in 218 patients with ET. However, the platelet count positively correlated with sTXB2 in patients not being treated with cytoreductive drugs (ρ = 0.51, P < 0.01, n = 84), but not in patients on cytoreduction. Patients in the lowest sTXB2 quartile were older, more often on cytoreductive drugs, had lower platelet count and Janus‐Associated Kinase2 (JAK2)‐V617F allele frequency as compared with patients in the upper sTXB2 quartiles. After 2 weeks of a twice‐ or 3‐times daily aspirin regimen, the association between the platelet count and sTXB2 became similar in cytoreduced and non‐cytoreduced patients. In conclusion, the platelet count appears the strongest determinant of TXA2 inhibition by once‐daily low‐dose aspirin in ET, with different patterns depending of cytoreductive treatment. More frequent aspirin dosing restores adequate platelet inhibition and reduces interindividual variability, independently of cytoreduction. [ABSTRACT FROM AUTHOR]

Published
2022
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42. A randomized double-blind trial of 3 aspirin regimens to optimize antiplatelet therapy in essential thrombocythemia

Author

Rocca, Bianca, primary, Tosetto, Alberto, primary, Betti, Silvia, primary, Soldati, Denise, primary, Petrucci, Giovanna, primary, Rossi, Elena, primary, Timillero, Andrea, primary, Cavalca, Viviana, primary, Porro, Benedetta, primary, Iurlo, Alessandra, primary, Cattaneo, Daniele, primary, Bucelli, Cristina, primary, Dragani, Alfredo, primary, Di Ianni, Mauro, primary, Ranalli, Paola, primary, Palandri, Francesca, primary, Vianelli, Nicola, primary, Beggiato, Eloise, primary, Lanzarone, Giuseppe, primary, Ruggeri, Marco, primary, Carli, Giuseppe, primary, Elli, Elena Maria, primary, Carpenedo, Monica, primary, Randi, Maria Luigia, primary, Bertozzi, Irene, primary, Paoli, Chiara, primary, Specchia, Giorgina, primary, Ricco, Alessandra, primary, Vannucchi, Alessandro Maria, primary, Rodeghiero, Francesco, primary, Patrono, Carlo, primary, and De Stefano, Valerio, primary

Published
2020
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43. Decreased NOTCH1 Activation Correlates with Response to Ibrutinib in Chronic Lymphocytic Leukemia

Author

Del Papa, Beatrice, primary, Baldoni, Stefano, additional, Dorillo, Erica, additional, De Falco, Filomena, additional, Rompietti, Chiara, additional, Cecchini, Debora, additional, Cantelmi, Maria Grazia, additional, Sorcini, Daniele, additional, Nogarotto, Manuel, additional, Adamo, Francesco Maria, additional, Mezzasoma, Federica, additional, Silva Barcelos, Estevão Carlos, additional, Albi, Elisa, additional, Iacucci Ostini, Roberta, additional, Di Tommaso, Ambra, additional, Marra, Andrea, additional, Montanaro, Guido, additional, Martelli, Maria Paola, additional, Falzetti, Franca, additional, Di Ianni, Mauro, additional, Rosati, Emanuela, additional, and Sportoletti, Paolo, additional

Published
2019
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44. Adoptive Immunotherapy with Regulatory and Conventional T Cells in Haploidentical Transplantation Primes Dendritic Cells to Promote T Cell Alloreactivity in the Bone Marrow and Tolerance in the Periphery

Author

Di Ianni, Mauro, primary, Giancola, Raffaella, additional, Baldoni, Stefano, additional, Ulbar, Francesca, additional, Del Papa, Beatrice, additional, Santarone, Stella, additional, Natale, Annalisa, additional, Olioso, Paola, additional, Di Bartolomeo, Paolo, additional, Bonfini, Tiziana, additional, Accorsi, Patrizia, additional, Sportoletti, Paolo, additional, Carotti, Alessandra, additional, Pierini, Antonio, additional, Ruggeri, Loredana, additional, Falzetti, Franca, additional, Martelli, Massimo Fabrizio, additional, and Velardi, Andrea, additional

Published
2019
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45. Regulatory T Cell Adoptive Immunotherapy Promotes B Cell Immunity after Haploidentical Transplantation

Author

Piccinelli, Sara, primary, Mancusi, Antonella, additional, Hoxha, Eni, additional, Ruggeri, Loredana, additional, Falzetti, Franca, additional, Carotti, Alessandra, additional, Terenzi, Adelmo, additional, Bonato, Samanta, additional, Paradiso, Matteo, additional, Zei, Tiziana, additional, Iacucci Ostini, Roberta, additional, Bigerna, Barbara, additional, Falini, Brunangelo, additional, Di Ianni, Mauro, additional, Martelli, Massimo Fabrizio, additional, Velardi, Andrea, additional, and Pierini, Antonio, additional

Published
2019
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47. 220 - DONOR Lymphocyte Infusions after Haploidentical STEM Cell Transplantation with Ptcy: A Study on Behalf of the Ctiwp of the EBMT

Author

Santoro, Nicole, Mauff, Katya, Devillier, Raynier, Castagna, Luca, Gülbas, Zafer, Diez-Martin, José Luis, Bermúdez, Arancha, Arroyo, Concepcion Herrera, Deconinck, Eric, Sierra, Jorge, Abecasis, Manuel, Ozdogu, Hakan, Mico, Maria Caterina, Rocha, Vanderson, Guyotat, Denis, Chalandon, Yves, Forcade, Edouard, Martin, Hans, Saccardi, Riccardo, Giebel, Sebastian, Di Ianni, Mauro, Hoogenboom, Jorinde, de Wreede, Liesbeth C, Ruggeri, Annalisa, and Chabannon, Christian

Published
2021
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48. Pomalidomide and Dexamethasone for Relapsed/Refractory Multiple Myeloma: A Single-Center Real Life Experience

Author

Cantò, Chiara, primary, Ranucci, Elena, additional, Pulini, Stefano, additional, Santoleri, Fiorenzo, additional, Morelli, Anna Maria, additional, Fioritoni, Francesca, additional, Falorio, Simona, additional, Torti, Lorenza, additional, Spadano, Antonio, additional, D'Aloisio, Marianna, additional, Di Ianni, Mauro, additional, Santarone, Stella, additional, and Di Bartolomeo, Paolo, additional

Published
2018
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49. How Adoptive Immunotherapy with Conventional T and Regulatory T Cells Exerts a Gvl Effect without GvHD, after Haploidentical Hematopoietic Transplantation

Author

Ruggeri, Loredana, primary, Carotti, Alessandra, additional, Pierini, Antonio, additional, Falzetti, Franca, additional, Terenzi, Adelmo, additional, Urbani, Elena, additional, Lucia, Amico, additional, Tricarico, Sara, additional, Piccinelli, Sara, additional, Massei, Maria Speranza, additional, Ciardelli, Sara, additional, Di Ianni, Mauro, additional, Zei, Tiziana, additional, Iacucci Ostini, Roberta, additional, Lancellotta, Valentina, additional, Saldi, Simonetta, additional, Minelli, Olivia, additional, Tognellini, Rita, additional, Merluzzi, Mara, additional, Marchesi, Mauro, additional, Caniglia, Maurizio, additional, Aristei, Cynthia, additional, Falini, Brunangelo, additional, Martelli, Massimo Fabrizio, additional, and Velardi, Andrea, additional

Published
2018
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50. NOTCH and Graft-Versus-Host Disease

Author

Di Ianni, Mauro, primary, Del Papa, Beatrice, additional, Baldoni, Stefano, additional, Di Tommaso, Ambra, additional, Fabi, Bianca, additional, Rosati, Emanuela, additional, Natale, Annalisa, additional, Santarone, Stella, additional, Olioso, Paola, additional, Papalinetti, Gabriele, additional, Giancola, Raffaella, additional, Accorsi, Patrizia, additional, Di Bartolomeo, Paolo, additional, Sportoletti, Paolo, additional, and Falzetti, Franca, additional

Published
2018
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