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Your search keyword '"Dey, Rakhi Sharma"' showing total 6 results
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6 results on '"Dey, Rakhi Sharma"'

1. Phytochemicals Safeguard the Genome: Tiny Molecules, Big Role

Author

Dey, Sanjit, primary, Das, Nilanjan, additional, Ganguli, Debdutta, additional, Sinha, Mahuya, additional, Sikder, Kunal, additional, Kesh, Swaraj Bandhu, additional, Das, Dipesh Kr, additional, Khan, Amitava, additional, Das, Ujjal, additional, Manna, Krishnendu, additional, Biswas, Sushobhan, additional, Pradhan, Anirban, additional, and Dey, Rakhi Sharma, additional

Published
2015
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6. Seabuckthron (Hippophae rhamnoides L.) leaf extract ameliorates the gamma radiation mediated DNA damage and hepatic alterations.

Author

Khan A, Manna K, Chinchubose, Das DK, Sinha M, Kesh SB, Das U, Dey RS, Banerji A, and Dey S

Subjects
Animals, DNA, Superhelical chemistry, DNA, Superhelical drug effects, DNA, Superhelical radiation effects, Free Radical Scavengers chemistry, Gamma Rays, Liver chemistry, Liver pathology, Male, Mice, Plant Extracts chemistry, Plant Leaves chemistry, DNA Damage drug effects, Free Radical Scavengers pharmacology, Hippophae chemistry, Liver drug effects, Plant Extracts pharmacology
Abstract

In vitro assessment showed that H. rhamnoides (HrLE) extract possessed free radical scavenging activities and can protect gamma (gamma) radiation induced supercoiled DNA damage. For in vivo study, Swiss albino mice were administered with HrLE (30 mg/kg body weight) for 15 consecutive days before exposing them to a single dose of 5 Gy of beta radiation. HrLE significantly prevented the radiation induced genomic DNA damage indicated as a significant reduction in the comet parameters. The lipid peroxidation, liver function enzymes, expression of phosphorylated NFkappaB (p65) and IkappaBalpha increased whereas the endogenous antioxidants diminished upon radiation exposure compared to control. Pretreatment of HrLE extract ameliorated these changes. Based on the present results it can be concluded that H. rhamnoides possess a potential preventive element in planned and accidental nuclear exposures.

Published
2014

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